# newdoc id = events.txt
# newpar
# sent_id = 1
# text = Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-kappaB.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	12	12	NUM	CD	NumType=Card	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	development	development	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	_
12	salicylic	salicylic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2
# text = IL-12 is a 75-kDa heterodimeric cytokine composed of two covalently linked p35 and p40 chains.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	covalently	covalently	ADV	RB	_	_	_	_	_
15	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	p35	p35	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p40	p40	NUM	CD	NumType=Card	_	_	_	_
19	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3
# text = This pro-inflammatory cytokine plays a prominent role in the development of Th1 cell-mediated immune responses.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4
# text = Th1 cell-mediated immune responses have been implicated in the pathogenesis of chronic inflammatory autoimmune diseases.
1	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
6	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	autoimmune	autoimmune	NOUN	NN	Number=Sing	_	_	_	_
17	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5
# text = Thus, IL-12 appears to be a critical factor in the generation and maintenance of chronic inflammatory conditions.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	12	12	NUM	CD	NumType=Card	_	_	_	_
6	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
19	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6
# text = In this study, we investigated the effects of a commonly prescribed anti-inflammatory drug, acetyl salicylic acid (ASA), on IL-12 production and Th1 cell development.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	commonly	commonly	ADV	RB	_	_	_	_	_
12	prescribed	prescri	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	_
17	salicylic	salicylic	ADJ	JJ	Degree=Pos	_	_	_	_
18	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	12	12	NUM	CD	NumType=Card	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7
# text = ASA was found to inhibit secretion of the IL-12 heterodimer as well as p40 monomer by human monocytic cells.
1	ASA	ASa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	p40	p40	NUM	CD	NumType=Card	_	_	_	_
17	monomer	monomer	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8
# text = This was associated with the down-regulation of IL-12p40 mRNA expression.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	12p40	12p40	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9
# text = Analysis of the regulation of the p40 gene promoter revealed that ASA inhibited NF-kappaB activation and binding to the p40-kappaB site in the p40 promoter, leading to transcriptional repression of the p40 gene.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	p40	p40	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	_
13	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p40	p40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10
# text = Addition of ASA to an in vitro T helper cell differentiation system, at concentrations compatible with plasma levels reached during anti-inflammatory therapy, resulted in reduced development of Th1 cells.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
16	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	development	development	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11
# text = These results suggest that the inhibition of NF-kappaB activation by ASA leads to down-regulation of IL-12 production and inhibition of Th1 cell development.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ASA	ASa	PROPN	NNP	Number=Sing	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	12	12	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12
# text = Document 0030020 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030020	0030020	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 13
# text = NF-kappa B controls expression of inhibitor
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 14
# text = I kappa
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 15
# text = B alpha:
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 16
# text = evidence for an inducible autoregulatory pathway.
1	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 17
# text = The eukaryotic transcription factor nuclear factor-kappa B (NF-kappa B) participates in many parts of the genetic program mediating T lymphocyte activation and growth.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
19	parts	part	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
23	program	program	NOUN	NN	Number=Sing	_	_	_	_
24	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 18
# text = Nuclear expression of NF-kappa B occurs after its induced dissociation from its cytoplasmic inhibitor
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 19
# text = I kappa B alpha.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 20
# text = Phorbol ester and tumor necrosis factor-alpha induction of nuclear NF-kappa B is associated with both the degradation of performed I kappa B alpha and the activation of I kappa B alpha gene expression.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	ADV	RB	_	_	_	_	_
35	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 21
# text = Transfection studies indicate that the I kappa B alpha gene is specifically induced by the 65-kilodalton transactivating subunit of NF-kappa B.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	GW	_	_	_	_	_
8	B	b	X	GW	_	_	_	_	_
9	alpha	alpha	X	GW	_	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kilodalton	kilodalton	NOUN	NN	Number=Sing	_	_	_	_
19	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 22
# text = Association of the newly synthesized I kappa B alpha with p65 restores intracellular inhibition of NF-kappa B DNA binding activity and prolongs the survival of this labile inhibitor.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	newly	newly	ADV	RB	_	_	_	_	_
5	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	p65	p65	NUM	CD	NumType=Card	_	_	_	_
12	restores	restore	NOUN	NNS	Number=Plur	_	_	_	_
13	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	prolongs	prolong	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
30	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 23
# text = Together, these results show that NF-kappa B controls the expression of I kappa B alpha by means of an inducible autoregulatory pathway.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	means	means	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 24
# text = Document 00300212 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300212	00300212	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 25
# text = Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	hypochlorous	hypochlorous	ADJ	JJ	Degree=Pos	_	_	_	_
17	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 26
# text = Reactive oxygen species (ROS) such as hydrogen peroxide serve as second messengers in the induction of the transcription factor NF-kappaB, and hence in the activation and replication of human immunodeficiency virus type 1 (HIV-1) in human cells.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
3	species	species	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
10	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
11	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	hence	hence	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
36	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
37	type	type	NOUN	NN	Number=Sing	_	_	_	_
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 27
# text = During inflammatory reactions, many oxidative species are produced, one of which is hypochlorous acid (HOCl), which is responsible for the microbicidal effects of activated human polymorphonuclear leukocytes.
1	During	during	ADP	IN	_	_	_	_	_
2	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
7	species	species	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Int	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	hypochlorous	hypochlorous	ADV	RB	_	_	_	_	_
16	acid	acid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	microbicidal	microbicidal	ADJ	JJ	Degree=Pos	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	polymorphonuclear	polymorphonuclear	NOUN	NN	Number=Sing	_	_	_	_
32	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 28
# text = Treatment of a T-lymphocytic cell line with micromolar concentrations of
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	micromolar	micromolar	ADJ	JJ	Degree=Pos	_	_	_	_
10	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_

# sent_id = 29
# text = HOCl promoted the appearance of transcription factor NF-kappaB (the heterodimer p50/p65) in the nucleus of the cells, even in the absence of de novo protein synthesis.
1	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
2	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	even	even	ADV	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	de	de	NOUN	NN	Number=Sing	_	_	_	_
31	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 30
# text = Western blot analysis of the NF-kappaB inhibitory subunits (IkappaB) demonstrated that both IkappaB-alpha proteolysis and p105 processing were induced by the treatment.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p105	p105	NUM	CD	NumType=Card	_	_	_	_
23	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 31
# text = NF-kappaB activation was very effective when cells were subjected to hyperthermia before being treated with HOCl.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	very	very	ADV	RB	_	_	_	_	_
7	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	subjected	subject	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
14	before	before	SCONJ	IN	_	_	_	_	_
15	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 32
# text = Various antioxidants, such as pyrrolidine dithiocarbamate, p-bromophenacyl-bromide and nordihydroguaiaretic acid could strongly reduce NF-kappaB translocation, demonstrating the importance of oxidative species in the transduction mechanism.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	pyrrolidine	pyrrolidine	ADJ	JJ	Degree=Pos	_	_	_	_
7	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p-bromophenacyl-bromide	p-bromophenacyl-bromide	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nordihydroguaiaretic	nordihydroguaiaretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
13	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
14	strongly	strongly	ADV	RB	_	_	_	_	_
15	reduce	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
26	species	species	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 33
# text = Moreover, ACH-2 cells treated with HOCl or H2O2 released tumour necrosis factor-alpha (TNF-alpha) in the supernatants.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ACH	ACH	DET	DT	_	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	H2O2	H2O2	PART	TO	Abbr=Yes	_	_	_	_
12	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 34
# text = The importance of TNF-alpha release in NF-kappaB induction by HOCl or H2O2 was demonstrated by the fact that: (1) the nuclear appearance of NF-kappaB was promoted in untreated cells; and (2) synergism between TNF-alpha and HOCl was detected.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	release	release	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	H2O2	H2O2	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	1	1	X	LS	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	;	;	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	2	2	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
45	between	between	ADP	IN	_	_	_	_	_
46	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
51	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
52	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 35
# text = Collectively, these results suggest that HOCl should be considered as an oxidative species capable of inducing NF-kappaB in a T-lymphocytic cell line through a transduction mechanism involving ROS, and having a long-distance effect through subsequent TNF-alpha release.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
8	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
14	species	species	NOUN	NNS	Number=Plur	_	_	_	_
15	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
31	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
32	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	distance	distance	NOUN	NN	Number=Sing	_	_	_	_
40	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
43	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
46	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 36
# text = Document 00300215 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300215	00300215	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 37
# text = Human interferon regulatory factor 2 gene.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	interferon	interferon	ADP	IN	_	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 38
# text = Intron-exon organization and functional analysis of 5'-flanking region.
1	Intron-exon	Intron-exon	ADP	IN	_	_	_	_	_
2	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 39
# text = Interferon regulatory factor 2 (IRF-2) is a transcriptional regulatory protein that terminates interferon beta expression initiated by interferon regulatory factor
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	terminates	terminate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	interferon	interferon	ADP	IN	_	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 40
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 41
# text = In this study, we isolated the genomic DNA for human IRF-2 gene, determined the intron-exon structure of the human IRF-2 gene, mapped the major transcription initiation site, identified a number of potential regulatory elements in the 5'-flanking region, and localized the IRF-2 gene on human chromosome 4.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
22	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	number	number	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
43	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
44	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
51	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	2	2	NUM	CD	NumType=Card	_	_	_	_
59	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
60	on	on	ADP	IN	_	_	_	_	_
61	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
62	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
63	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 42
# text = The IRF-2 promoter region contains a CpG island, with several GC boxes, a putative NF-kappa B-binding site, and a CAAT box, but no TATA box.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	CpG	CpG	PROPN	NNP	Number=Sing	_	_	_	_
10	island	island	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
15	boxes	box	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	CAAT	Caat	NOUN	NN	Number=Sing	_	_	_	_
30	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
35	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 43
# text = When the promoter region was linked with a heterologous reporter gene, we found that the promoter region is inducible by both interferons (interferon-alpha and -gamma) and interferon regulatory factor
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
10	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	interferon	interferon	ADP	IN	_	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 44
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 45
# text = The region which induced these inductions was identified as being confined to 40 nucleotides 5' to the major transcriptional initiation site by testing a series of clones with truncated promoter of IRF-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	inductions	induction	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
11	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	40	40	NUM	CD	NumType=Card	_	_	_	_
14	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	testing	teste	VERB	VBG	VerbForm=Ger	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	series	series	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 46
# text = This region contains elements which are shared with the transcriptional enhancers of other genes including interferon regulatory factor 1, interferon beta, and interferon-inducible genes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	shared	share	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	interferon	interferon	ADP	IN	_	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	interferon	interferon	ADP	IN	_	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 47
# text = These data suggest that interferon regulatory factor 1 not only triggers the activation of the interferon signal transduction pathway, but also may play a role in limiting the duration of this response by activating the transcription of IRF-2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interferon	interferon	ADP	IN	_	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	triggers	trigger	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	SCONJ	IN	_	_	_	_	_
28	limiting	limite	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	SCONJ	IN	_	_	_	_	_
35	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 48
# text = Document 00300221 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300221	00300221	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 49
# text = IL-10 inhibits nuclear factor-kappa B/Rel nuclear activity in CD3-stimulated human peripheral T lymphocytes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 50
# text = IL-10 markedly reduces nuclear factor (NF)-kappa B/Rel nuclear activity induced in PBMC by stimulation with the anti-CD3 mAb OKT3.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	markedly	markedly	ADV	RB	_	_	_	_	_
5	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
26	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
27	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 51
# text = The inhibition is exerted specifically on the NF-kappa B/Rel activation induced by mAb OKT3, and not that produced by PMA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
18	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 52
# text = As judged by supershifting the DNA-protein complexes with Abs recognizing specific components of the NF-kappa B/Rel protein family, the p50/p65 (Rel A) heterodimeric form of NF-kappa B is primarily affected.
1	As	as	SCONJ	IN	_	_	_	_	_
2	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	supershifting	supershift	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Abs	Abs	PROPN	NNPS	Number=Plur	_	_	_	_
12	recognizing	recognize	VERB	VBG	VerbForm=Ger	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	components	component	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
32	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
35	form	form	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	primarily	primarily	ADV	RB	_	_	_	_	_
43	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 53
# text = The maximal effect is observed at the IL-10 concentration of 20 U/ml.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	20	20	NUM	CD	NumType=Card	_	_	_	_
14	U/ml	u/ml	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 54
# text = IL-10 inhibitory activity is exerted on T lymphocytes and is mediated by monocytes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	exerted	exert	VERB	VBN	Tense=Past|Typo=Yes|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 55
# text = Indeed, monocytes pretreated with IL-10 are able so inhibit NF-kappa B nuclear activity in purified T lymphocytes stimulated with OKT3.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	so	so	ADV	RB	_	_	_	_	_
12	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 56
# text = Soluble factors do not appear to be involved in the mechanism of inhibition.
1	Soluble	Soluble	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 57
# text = On the other hand, the up-regulation of CD80
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 58
# text = Ag, found on monocytes obtained from PBMC incubated with OKT3, is not detected after addition of IL-10, and the anti-CD28 mAb CLB-CD28/1 restores the NF-kappa B/Rel nuclear activity in IL-10-inhibited lymphocytes.
1	Ag	ag	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
9	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	anti-CD28	anti-CD28	PROPN	NNP	Number=Sing	_	_	_	_
26	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
27	CLB	CLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	CD28/1	CD28/1	PROPN	NNP	Number=Sing	_	_	_	_
30	restores	restore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 59
# text = Therefore, the NF-kappa B/Rel inhibition might be ascribed to a lack of cooperation between accessory cells and T lymphocytes, resulting from down-regulation of a costimulatory molecule, such as CD80, produced by IL-10 on activated monocytes.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	ascribed	ascribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
34	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	10	10	NUM	CD	NumType=Card	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 60
# text = Our results demonstrate that IL-10 can inhibit the induction of NF-kappa B/Rel nuclear activity in CD3-stimulated T lymphocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 61
# text = Since inappropriate activation of kappa B-driven genes has a physiopathologic role in a number of diseases, such as HIV infection, our findings support the possibility of using this cytokine to suppress an undesirable activation of these transcription factors.
1	Since	since	ADP	IN	_	_	_	_	_
2	inappropriate	inappropriate	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	physiopathologic	physiopathologic	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	number	number	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
26	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
27	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	undesirable	undesirable	ADJ	JJ	Degree=Pos	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 62
# text = Document 00300223 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300223	00300223	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 63
# text = TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	synergistically	synergistically	ADV	RB	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
19	TRE	tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
22	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 64
# text = Activating protein-1 (AP-1) binding TPA responsive elements (TRE) are located downstream of the transcription initiation site in the U5 region of the HIV-1 long terminal repeat (LTR).
1	Activating	Activat	VERB	VBG	VerbForm=Ger	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	TPA	Tpa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TRE	Tre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	U5	U5	PROPN	NNP	Number=Sing	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
34	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
35	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 65
# text = These downstream sequence elements, termed DSE, can bind both AP-1 and CREB/ATF transcription factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CREB	Creb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	ATF	Atf	PROPN	NNP	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 66
# text = Recently, we demonstrated that the DSE are also cAMP-responsive elements (CRE), since they mediated activation signals elicited by cholera toxin (Ctx), a potent activator of the cAMP-dependent protein kinase A (PKA) signal transduction pathway.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	cAMP	camp	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	since	since	SCONJ	IN	_	_	_	_	_
19	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
20	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
23	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
26	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
33	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	A	A	PROPN	NNP	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
46	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
47	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 67
# text = In the present study, we demonstrate that the HIV-1 DSE can mediate the transcriptional synergy elicited by the combination of Ctx and TNFalpha.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
19	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 68
# text = Ctx combined with TNFalpha or IL-1beta to produce a synergistic increase in p24 antigen production in U1 promonocytic cells.
1	Ctx	Ctx	NOUN	NN	Number=Sing	_	_	_	_
2	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	p24	p24	NUM	CD	NumType=Card	_	_	_	_
16	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	U1	U1	NUM	CD	NumType=Card	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 69
# text = Transfection studies of LTR reporter constructs indicated that mutation of the DSE sites abrogated the LTR-mediated synergy induced by Ctx and TNFalpha, whereas the synergy induced by Ctx and IL-1beta was unaffected, suggesting TNFalpha and IL-1beta cooperate differently with the cAMP/PKA activation pathway to induce HIV-1 expression in U1 cells.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LTR	Ltr	ADJ	JJ	Degree=Pos	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	DSE	DSE	PROPN	NNP	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	abrogated	abrogate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	LTR-	ltr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
46	cooperate	cooperate	NOUN	NN	Number=Sing	_	_	_	_
47	differently	differently	ADV	RB	_	_	_	_	_
48	with	with	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
52	PKA	PKa	NOUN	NN	Number=Sing	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
55	to	to	PART	TO	_	_	_	_	_
56	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
57	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1	1	NUM	CD	NumType=Card	_	_	_	_
60	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
61	in	in	ADP	IN	_	_	_	_	_
62	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
63	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 70
# text = Because the DSE are also TRE sites, we assessed the effect of the agonist combinations on AP-1-dependent transcription.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	TRE	Tre	ADJ	JJ	Degree=Pos	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	assessed	assess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
16	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 71
# text = TNFalpha as well as IL-1beta cooperated with Ctx to produce a synergistic activation of AP-1-mediated transcription.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	as	as	ADV	RB	_	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	cooperated	cooperate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 72
# text = These data indicate that the TRE-like cAMP-responsive DSE sites within the 5'-untranslated leader can mediate the transcriptional cooperativity between TNFalpha and the cAMP/PKA pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'	's	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
20	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	cooperativity	cooperativity	NOUN	NN	Number=Sing	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	PKA	PKa	NOUN	NN	Number=Sing	_	_	_	_
33	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 73
# text = Since the DSE and TRE sites cannot bind CREB/ATF homodimers, we propose a mechanism in which the HIV-1 DSE bind heterodimers composed of both AP-1 and CREB/ATF proteins.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
8	not	not	PART	RB	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
13	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
26	bind	bind	ADP	IN	_	_	_	_	_
27	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
28	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 74
# text = Copyright 1997 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1997	1997	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 75
# text = Document 00300229 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300229	00300229	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 76
# text = Signaling events induced by lipopolysaccharide-activated toll-like receptor
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	events	event	NOUN	NNS	Number=Plur	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	toll	toll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 77
# text = 2.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 78
# text = Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates NF-kappaB.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	Toll	toll	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	responds	respond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 79
# text = Here, we investigate further the events triggered by TLR2 in response to LPS.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	further	further	ADV	RBR	Degree=Cmp	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	events	event	NOUN	NNS	Number=Plur	_	_	_	_
8	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 80
# text = We show that TLR2 associates with the high-affinity LPS binding protein membrane CD14 to serve as an LPS receptor complex, and that LPS treatment enhances the oligomerization of TLR2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
5	associates	associate	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	LPS	Lp	NOUN	NN	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
15	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
27	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
28	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 81
# text = Concomitant with receptor oligomerization, the IL-1R-associated kinase (IRAK) is recruited to the TLR2 complex.
1	Concomitant	Concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL-	Il-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	1R-	1R-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 82
# text = Intracellular deletion variants of TLR2 lacking C-terminal 13 or 141 aa fail to recruit IRAK, which is consistent with the inability of these mutants to transmit LPS cellular signaling.
1	Intracellular	Intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
6	lacking	lack	NOUN	NN	Number=Sing	_	_	_	_
7	C-	C-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	141	141	NUM	CD	NumType=Card	_	_	_	_
12	aa	a	DET	DT	Typo=Yes	_	_	_	_
13	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	recruit	recruit	VERB	VB	VerbForm=Inf	_	_	_	_
16	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	transmit	transmit	VERB	VB	VerbForm=Inf	_	_	_	_
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
31	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 83
# text = Moreover, both deletion mutants could still form complexes with wild-type TLR2 and act in a dominant-negative (DN) fashion to block TLR2-mediated signal transduction.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	still	still	ADV	RB	_	_	_	_	_
8	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
9	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	act	act	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	DN	DN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
28	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
32	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 84
# text = DN constructs of myeloid differentiation protein, IRAK, TNF receptor-associated factor 6, and NF-kappaB-inducing kinase, when coexpressed with TLR2, abrogate TLR2-mediated NF-kappaB activation.
1	DN	Dn	ADJ	JJ	Degree=Pos	_	_	_	_
2	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	when	when	ADV	WRB	PronType=Int	_	_	_	_
26	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	abrogate	abrogate	ADJ	JJ	Degree=Pos	_	_	_	_
31	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 85
# text = These results reveal a conserved signaling pathway for TLR2 and IL-1Rs and suggest a molecular mechanism for the inhibition of TLR2 by DN variants.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1Rs	-1R	PROPN	NNPS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	DN	Dn	ADJ	JJ	Degree=Pos	_	_	_	_
25	variants	variant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 86
# text = Document 00300232 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300232	00300232	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 87
# text = The role of p16 in the E2F-dependent thymidine kinase regulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p16	p16	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 88
# text = The role of alterations of the MTS1 tumor suppressor gene on chromosome 9p21, which encodes p16, the inhibitor of cyclin-dependent-kinase-4 and 6, in tumorigenesis is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	MTS1	MTS1	PROPN	NNP	Number=Sing	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	9p21	9p21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	4	4	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	tumorigenesis	tumorigenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	yet	yet	ADV	RB	_	_	_	_	_
37	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 89
# text = Phosphorylation of the retinoblastoma protein by cyclin-dependent kinases 4 and 6 prevents its interaction with the transcription factor E2F, which subsequently promotes the expression of S phase regulated genes, such as thymidine kinase.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	subsequently	subsequently	ADV	RB	_	_	_	_	_
25	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	S	s	PROPN	NNP	Number=Sing	_	_	_	_
30	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	thymidine	thymidine	PRON	PRP	_	_	_	_	_
37	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 90
# text = Although a role of p16 in this regulation has been presumed, there is no proof so far that loss of this tumor suppressor gene really affects E2F-mediated regulations.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p16	p16	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	there	there	PRON	EX	_	_	_	_	_
14	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	proof	proof	ADJ	JJ	Degree=Pos	_	_	_	_
17	so	so	ADV	RB	_	_	_	_	_
18	far	far	ADV	RB	Degree=Pos	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	really	really	ADV	RB	_	_	_	_	_
27	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	regulations	regulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 91
# text = We investigated the regulation of thymidine kinase in phytohemagglutinin-stimulated normal human lymphocytes and in the p16-negative human acute lymphoblastic leukemia cell lines, MOLT-4 and CEM.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	thymidine	thymidine	PRON	PRP	_	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-negative	-negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
22	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	MOLT	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 92
# text = Compared to normal lymphocytes, MOLT-4 and CEM cells exhibited an altered cell cycle regulation of thymidine kinase, a much higher intracellular activity of this enzyme, and higher thymidine kinase mRNA expression.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	MOLT	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
24	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
25	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
33	thymidine	thymidine	PRON	PRP	_	_	_	_	_
34	kinase	kinase	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 93
# text = Transient expression of p16 in normal human lymphocytes caused arrest in G1, but was without effect on the cell growth of MOLT-4 and CEM cells, although all of them express functional retinoblastoma protein.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p16	p16	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	without	without	ADP	IN	_	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	MOLT	MOLT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	although	although	SCONJ	IN	_	_	_	_	_
31	all	all	DET	DT	_	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
34	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
35	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
36	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 94
# text = Nevertheless, in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase, paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free E2F bound to its motif in the thymidine kinase promoter.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
10	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	16	16	NUM	CD	NumType=Card	_	_	_	_
14	reestablished	reestablish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thymidine	thymidine	PRON	PRP	_	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	underphosphorylated	underphosphorylated	ADJ	JJ	Degree=Pos	_	_	_	_
29	form	form	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
37	E2	e2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	F	F	PROPN	NNP	Number=Sing	_	_	_	_
39	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
47	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 95
# text = We demonstrate that loss of p16 causes upregulation of this DNA precursor pathway enzyme via activation of E2F by a mechanism involving retinoblastoma protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p16	p16	NUM	CD	NumType=Card	_	_	_	_
7	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
8	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
15	via	via	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	F	F	PROPN	NNP	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
24	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 96
# text = Document 00300233 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300233	00300233	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 97
# text = Modulation of endogenous IL-1 beta and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	opposing	oppose	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	chronically	chronically	ADV	RB	_	_	_	_	_
23	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 98
# text = A proportion of HIV-infected individuals experience episodes of localized or systemic bacterial infections caused by Gram-negative bacteria.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
7	experience	experience	NOUN	NN	Number=Sing	_	_	_	_
8	episodes	episode	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
13	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
14	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
15	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	Gram	Gram	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	bacteria	bacterion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 99
# text = Many of the clinical side effects of these infections are associated with the production of proinflammatory cytokines, which are induced primarily by LPS, a constituent of the bacterial cell wall of Gram-negative bacteria.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
5	side	side	NOUN	NN	Number=Sing	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	primarily	primarily	ADV	RB	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	constituent	constituent	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Gram-	Gram-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
36	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 100
# text = The present study examines the mechanisms involved in LPS-mediated induction of HIV expression in U1 cells, a promonocytic cell line chronically infected with HIV.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	examines	examine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	chronically	chronically	ADV	RB	_	_	_	_	_
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 101
# text = Stimulation of U1 cells by LPS alone induced minimal levels of HIV expression, which was significantly enhanced by granulocyte-macrophage colony-stimulating factor (GM-CSF).
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U1	U1	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	alone	alone	ADV	RB	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
23	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 102
# text = Costimulation of U1 cells with LPS plus GM-CSF resulted in the accumulation of steady-state levels of HIV RNA; however, only a weak induction of HIV long terminal repeat-driven transcription, which was not associated with the activation of the cellular transcription factor nuclear factor-kappa B, was noted.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U1	U1	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	plus	plus	CCONJ	CC	_	_	_	_	_
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	state	state	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
22	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
32	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
33	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
34	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	not	not	PART	RB	_	_	_	_	_
42	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
49	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
50	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
51	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
55	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
58	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 103
# text = Costimulation of cells with LPS plus GM-CSF induced the production of proinflammatory cytokines, IL-8, IL-1 beta and IL-6, but not TNF-alpha.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	plus	plus	CCONJ	CC	_	_	_	_	_
7	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 104
# text = IL-1 receptor antagonist (ra) inhibited LPS enhancement of HIV expression in GM-CSF-stimulated cells, suggesting that endogenous IL-1 was involved in LPS-mediated viral production.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ra	ra	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
11	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 105
# text = In this regard, anti-inflammatory cytokines inhibited LPS plus GM-CSF-stimulated HIV expression, and this effect closely correlated with inhibition of IL-1 beta release and, in particular, with up-regulation of endogenous IL-1ra production.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
9	plus	plus	CCONJ	CC	_	_	_	_	_
10	GM-	GM-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	closely	closely	ADV	RB	_	_	_	_	_
21	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	release	release	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	ra	ra	NOUN	NN	Number=Sing	_	_	_	_
44	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 106
# text = Thus, the balance between an endogenously produced viral inducer (IL-1 beta ) and an inhibitor (IL-1ra) may represent an important pathway leading to modulation of
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	endogenously	endogenously	ADV	RB	_	_	_	_	_
8	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1ra	1ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_

# sent_id = 107
# text = HIV expression from monocytic cells.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 108
# text = Document 00300235 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300235	00300235	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 109
# text = Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
13	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
19	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 110
# text = Tax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-kappaB, and SRF.
1	Tax1	Tax1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
28	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	through	through	ADP	IN	_	_	_	_	_
31	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	at	at	ADV	RB	_	_	_	_	_
34	least	least	ADV	RBS	Degree=Sup	_	_	_	_
35	three	three	NUM	CD	NumType=Card	_	_	_	_
36	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
37	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	;	;	PUNCT	,	_	_	_	_	_
41	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 111
# text = This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	Tax1	tax1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	event	event	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 112
# text = To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors.
1	To	to	PART	TO	_	_	_	_	_
2	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	each	each	DET	DT	_	_	_	_	_
7	Tax1	tax1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	introduced	introduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	Tax1	Tax1	NUM	CD	NumType=Card	_	_	_	_
20	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
27	into	into	ADP	IN	_	_	_	_	_
28	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
29	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	retroviral	retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
36	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 113
# text = Analysis of these PBLs revealed that activation of the NF-kappaB pathway is sufficient to promote the growth response to IL-2.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	PBLs	PBL	NOUN	NNS	Number=Plur	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 114
# text = However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	T-	T-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
17	result	result	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	_
32	pathways	pathways	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 115
# text = Document 00300238 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300238	00300238	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 116
# text = Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	SCONJ	IN	_	_	_	_	_
12	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
13	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 117
# text = CD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells.
1	CD40/CD40	CD40/CD40	NUM	CD	NumType=Card	_	_	_	_
2	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
3	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
11	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 118
# text = The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	widely	widely	ADV	RB	_	_	_	_	_
16	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	about	about	SCONJ	IN	_	_	_	_	_
27	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
28	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
29	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
30	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	tonsillar	tonsillar	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 119
# text = Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	highly	highly	ADV	RB	_	_	_	_	_
10	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 120
# text = After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations.
1	After	after	SCONJ	IN	_	_	_	_	_
2	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
3	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	both	both	DET	DT	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 121
# text = However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	components	component	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	part	part	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
32	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	both	both	DET	DT	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	whereas	whereas	SCONJ	IN	_	_	_	_	_
41	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	only	only	ADV	RB	_	_	_	_	_
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 122
# text = In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	although	although	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
45	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 123
# text = These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 124
# text = This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	hyper	hyper	NOUN	NN	Number=Sing	_	_	_	_
22	IgM	Igm	NOUN	NN	Number=Sing	_	_	_	_
23	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	whom	whom	PRON	WP	PronType=Rel	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 125
# text = B cell activation has been reported.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 126
# text = Document 00300243 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300243	00300243	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 127
# text = Identification of an I kappa B alpha-associated protein kinase in a human monocytic cell line and determination of its phosphorylation sites on I kappa B alpha.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	GW	_	_	_	_	_
6	B	B	X	GW	_	_	_	_	_
7	alpha	alpha	X	GW	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	B	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 128
# text = Nuclear factor kappa B (NF-kappa B) is stored in the cytoplasm as an inactive form through interaction with I kappa B. Stimulation of cells leads to a rapid phosphorylation of I kappa B alpha, which is presumed to be important for the subsequent degradation.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	stored	store	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	form	form	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
26	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
33	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	which	which	PRON	WDT	PronType=Rel	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
45	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
49	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 129
# text = We have recently reported the establishment of a lipopolysaccharide (LPS)-dependent cell-free activation system of NF-kappa B in association with the induction of I kappa B alpha phosphorylation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	establishment	establishment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	system	system	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	association	association	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	ADP	IN	_	_	_	_	_
35	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 130
# text = In this study, we have identified a kinase in cell extracts from the LPS-stimulated human monocytic cell line, THP-1, that specifically binds and phosphorylates I kappa B alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	specifically	specifically	ADV	RB	_	_	_	_	_
29	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	phosphorylates	phosphorylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 131
# text = LPS stimulation transiently enhanced the I kappa B alpha-bound kinase activity in THP-1 cells.
1	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	transiently	transiently	ADV	RB	_	_	_	_	_
4	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	I	I	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 132
# text = Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
10	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
14	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
15	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	Ser	Ser	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Thr	Thr	PROPN	NNP	Number=Sing	_	_	_	_
27	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
32	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
33	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	B	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 133
# text = Moreover, we show that the peptide, corresponding to the C-terminal acidic domain of I kappa B alpha, blocked the LPS-induced NF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using THP-1 cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
14	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
39	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
40	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
41	B	b	PROPN	NNP	Number=Sing	_	_	_	_
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
48	system	system	NOUN	NN	Number=Sing	_	_	_	_
49	using	using	VERB	VBG	VerbForm=Ger	_	_	_	_
50	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	1	1	NUM	CD	NumType=Card	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 134
# text = These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_

# sent_id = 135
# text = I kappa B alpha and subsequent dissociation of the NF-kappa B.I kappa B alpha complex.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
7	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
16	B	b	X	LS	_	_	_	_	_
17	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 136
# text = Document 00300245 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300245	00300245	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 137
# text = MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene.
1	MIP1	MIP1	X	LS	_	_	_	_	_
2	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	MNP	MNP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 138
# text = Murine macrophage inflammatory protein 1 alpha (MIP-1 alpha) and its human equivalent (GOS19, LD78, or AT464) are members of the -C-C family of low-molecular-weight chemokines.
1	Murine	Murine	PRON	PRP	_	_	_	_	_
2	macrophage	macrophage	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	equivalent	equivalent	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	GOS19	GOS19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	LD78	LD78	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	AT464	At464	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	C	C	PROPN	NNP	Number=Sing	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	low-	low-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
39	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 139
# text = Secreted from activated T cells and macrophages, bone marrow-derived MIP-1 alpha/GOS19 inhibits primitive hematopoietic stem cells and appears to be involved in the homeostatic control of stem cell proliferation.
1	Secreted	Secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	bone	bone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	GOS19	GOS19	NUM	CD	NumType=Card	_	_	_	_
19	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
20	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
21	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
22	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	homeostatic	homeostatic	ADJ	JJ	Degree=Pos	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 140
# text = It also induces chemotaxis and inflammatory responses in mature cell types.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	chemotaxis	chemotaxis	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 141
# text = Therefore, it is important to understand the mechanisms which control the expression of MIP-1 alpha/GOS19.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	MIP	MIP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	alpha/	alpha/	SYM	SYM	_	_	_	_	SpaceAfter=No
19	GOS19	GOS19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 142
# text = Previous work has shown that in Jurkat T cells, a set of widely expressed transcription factors (the ICK-1 family) affect the GOS19 promoter.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	set	set	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	widely	widely	ADV	RB	_	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	ICK	ICK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	affect	affect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	GOS19	GOS19	NUM	CD	NumType=Card	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 143
# text = One member, ICK-1A, behaves as a strong negative regulator.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	ICK	ICK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	behaves	behave	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 144
# text = In this communication, we provide evidence that the pathway of induction in the macrophage cell line U937 is different from that in Jurkat cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	communication	communication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 145
# text = Furthermore, we show that the ICK-1 binding site does not confer negative regulation in U937 cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ICK	Ick	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
15	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	U937	U937	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 146
# text = We provide evidence for an additional binding site, the MIP-1 alpha nuclear protein (MNP) site, which overlaps the ICK-1 site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	MNP	MNP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ICK	ick	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 147
# text = Interaction of nuclear extracts from various cell lines and tissue with the MNP site leads to the formation of fast-migrating protein-DNA complexes with similar but distinct electrophoretic mobilities.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	MNP	MNP	PROPN	NNP	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobilities	mobility	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 148
# text = A mutation of the MNP site which does not abrogate ICK-1 binding inactivates the GOS19.1 promoter in U937 cells and reduces its activity by fourfold in Jurkat cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MNP	MNP	PROPN	NNP	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	abrogate	abrogate	VERB	VB	VerbForm=Inf	_	_	_	_
11	ICK	Ick	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	inactivates	inactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	GOS19.1	Gos19.1	PROPN	NNP	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	U937	U937	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	fourfold	fourfold	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 149
# text = We propose that the MNP protein(s) binding at the MNP site constitutes a novel transcription factor(s) expressed in hematopoietic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MNP	Mnp	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	MNP	MNP	PROPN	NNP	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	constitutes	constitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	s	s	X	AFX	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 150
# text = Document 00300247 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300247	00300247	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 151
# text = Interferons induce normal and aberrant retinoic-acid receptors type alpha in acute promyelocytic leukemia cells: potentiation of the induction of retinoid-dependent differentiation markers.
1	Interferons	Interferon	NOUN	NNS	Number=Plur	_	_	_	_
2	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptors	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
14	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
27	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 152
# text = Treatment of the acute promyelocytic (APL) cell line NB4 with interferon alpha (IFN(alpha)), as well as IFN(beta) and gamma, results in an increased expression of the transcripts coding for retinoic-acid receptor type alpha (RAR(alpha)) and the leukemia-specific retinoic acid receptor PML-RAR.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
5	promyelocytic	promyelocytic	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	APL	APL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	NB4	Nb4	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	results	result	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
40	coding	cod	VERB	VBG	VerbForm=Ger	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
45	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
46	type	type	NOUN	NN	Number=Sing	_	_	_	_
47	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
59	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
60	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
61	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
62	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 153
# text = Transcriptional induction of the RAR(alpha) and PML-RAR mRNAs is rapid and it is parallelled by an increase in the corresponding proteins.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNAs	mRNAs	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	parallelled	parallell	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 154
# text = Up-regulation of RAR(alpha) and PML-RAR gene expression by IFN(alpha) is accompanied by a strong potentiation in the induction of 2 retinoid-dependent granulocytic markers, i.e., granulocyte-colony-stimulating factor receptor mRNA and leukocyte alkaline phosphatase.
1	Up-	Up-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
24	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
43	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
44	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
47	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
48	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 155
# text = However, IFN(alpha) does not have any effects on the retinoid-dependent regulation of the myeloid surface markers CD11b and CD33.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IFN(	IFN(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
9	any	any	DET	DT	_	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
20	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
21	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
22	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	b	b	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	CD33	CD33	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 156
# text = The IFN-dependent increase in RAR(alpha) levels and the enhancing effect of the cytokine on retinoid-dependent granulocytic markers expression may be a characteristic of PML-RAR positive cells, since the phenomena are not observed in HL-60 promyelocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
34	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	since	since	SCONJ	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	phenomena	phenomena	NOUN	NN	Number=Sing	_	_	_	_
40	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	not	not	PART	RB	_	_	_	_	_
42	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	60	60	NUM	CD	NumType=Card	_	_	_	_
47	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 157
# text = Interferons as well as retinoids inhibit the growth of NB4 cells, although the 2 classes of compounds do not significantly interact in terms of anti-proliferative activity.
1	Interferons	Interferon	NOUN	NNS	Number=Plur	_	_	_	_
2	as	as	ADV	RB	_	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
6	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	although	although	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
19	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	anti-proliferative	anti-proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 158
# text = These results suggest the possible use of combinations between IFNs and retinoic acid in the cyto-differentiating treatment of APL patients.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	use	use	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	IFNs	IFN	PROPN	NNPS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cyto-differentiating	cyto-differentiating	ADJ	JJ	Degree=Pos	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 159
# text = Document 00300248 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300248	00300248	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 160
# text = Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	proenkephalin	proenkephalin	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 161
# text = Upon activation, T lymphocytes accumulate high levels of the neuropeptide enkephalin which correlate with high levels of proenkephalin mRNA in the cells.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	accumulate	accumulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	neuropeptide	neuropeptide	ADJ	JJ	Degree=Pos	_	_	_	_
12	enkephalin	enkephalin	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	correlate	correlate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	proenkephalin	proenkephalin	ADJ	JJ	Degree=Pos	_	_	_	_
20	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 162
# text = Here we investigated the transcriptional basis for these changes.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 163
# text = The proenkephalin promoter contains a sequence GGGGACGTCCCC, named B2, which is similar to the kappa B sequence GGGGACTTTCC, the binding site of the transcription factor nuclear factor (NF)-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proenkephalin	proenkephalin	ADJ	JJ	Degree=Pos	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	GGGGACGTCCCC	Ggggacgtcccc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	named	nam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	B2	b2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	GGGGACTTTCC	GGGGACTTTCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 164
# text = Activation of T lymphocytes induces an NF-kappa B-like binding activity to the B2 site, concomitant with activation of the proenkephalin promoter.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	T	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	like	like	SCONJ	IN	_	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	proenkephalin	proenkephalin	ADJ	JJ	Degree=Pos	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 165
# text = Mutations at the B2 site abolish this transcriptional activation.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	B2	B2	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	abolish	abolish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 166
# text = The purified homodimer (two p50s) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s) form of the factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
3	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	p50s	p50	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	B2	B2	NUM	CD	NumType=Card	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
25	relatively	relatively	ADV	RB	_	_	_	_	_
26	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
27	than	than	ADP	IN	_	_	_	_	_
28	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	heterotetramer	heterotetramer	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	two	two	NUM	CD	NumType=Card	_	_	_	_
33	p65s	p65	NOUN	NNS	Number=Plur	_	_	_	_
34	plus	plus	CCONJ	CC	_	_	_	_	_
35	two	two	NUM	CD	NumType=Card	_	_	_	_
36	p50s	p50	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	form	form	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 167
# text = Thus, it appears that the T-cell-specific activation of the proenkephalin promoter is mediated by NF-kappa B.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 168
# text = However, as NF-kappa B is ubiquitous and the transcriptional activation through the B2 site is T cell specific, yet another T-cell-specific factor which synergizes with NF-kappa B should be considered.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	yet	yet	CCONJ	CC	_	_	_	_	_
24	another	another	DET	DT	_	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	synergizes	synergize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
38	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
39	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 169
# text = Document 00300253 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300253	00300253	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 170
# text = A hydrophobic domain of Ca2+-modulating cyclophilin ligand modulates calcium influx signaling in T lymphocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	hydrophobic	hydrophobic	ADJ	JJ	Degree=Pos	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Ca2+-	Ca2+-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	modulating	modulat	NOUN	NN	Number=Sing	_	_	_	_
7	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
8	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
9	modulates	modulate	NOUN	NNS	Number=Plur	_	_	_	_
10	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
11	influx	influx	SYM	SYM	_	_	_	_	_
12	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 171
# text = Ca2+-modulating cyclophilin ligand (CAML) was originally described as a cyclophilin B-binding protein whose overexpression in T cells causes a rise in intracellular calcium, thus activating transcription factors responsible for the early immune response.
1	Ca2	Ca2	X	LS	_	_	_	_	SpaceAfter=No
2	+-modulating	+-modulat	ADJ	JJ	Degree=Pos	_	_	_	_
3	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	originally	originally	ADV	RB	_	_	_	_	_
10	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
19	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	thus	thus	ADV	RB	_	_	_	_	_
31	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
38	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 172
# text = As reported here, structure-function analysis of the CAML gene in Jurkat T cells indicates that two of CAML's putative membrane-spanning domains are necessary and sufficient for the modulation of intracellular calcium.
1	As	as	SCONJ	IN	_	_	_	_	_
2	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	_
12	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	's	's	PART	POS	_	_	_	_	_
23	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
24	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	spanning	spanning	NOUN	NN	Number=Sing	_	_	_	_
27	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
37	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 173
# text = We propose that the hydrophobic C-terminal tail of CAML forms its effector domain, thus implicating the N-terminal hydrophilic domain in a regulatory role.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hydrophobic	hydrophobic	ADJ	JJ	Degree=Pos	_	_	_	_
6	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CAML	caml	ADJ	JJ	Degree=Pos	_	_	_	_
11	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	thus	thus	ADV	RB	_	_	_	_	_
17	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
21	hydrophilic	hydrophilic	ADJ	JJ	Degree=Pos	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 174
# text = These findings define a novel protein motif that functions in intracellular calcium signaling.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	motif	motif	SCONJ	IN	_	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 175
# text = Document 00300255 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300255	00300255	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 176
# text = Regulation of interleukin-1beta transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 177
# text = Epstein-Barr virus (EBV) infects B cells, resulting in the outgrowth of immortalised lymphoblastoid cell lines (LCLs).
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	immortalised	immortalise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LCLs	LCL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 178
# text = Here, we demonstrate through the use of intracellular staining that interleukin-1beta (IL-1beta) is expressed in LCLs and investigate the influence of the individual latent proteins on the expression of IL-1beta.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	use	use	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	LCLs	LCLs	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
32	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 179
# text = Using RT-PCR, IL-1beta was shown to be up-regulated in EBV-transformed LCLs as well as in group III Burkitt's lymphoma (BL) cell lines, compared with group I BL cell lines.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	LCLs	LCL	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	III	iii	PROPN	NNP	Number=Sing	_	_	_	_
28	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	's	's	PART	POS	_	_	_	_	_
30	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	group	group	NOUN	NN	Number=Sing	_	_	_	_
40	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
41	BL	Bl	AUX	MD	VerbForm=Fin	_	_	_	_
42	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
43	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 180
# text = The up-regulation of IL-1beta message could be mediated by the latent membrane protein-1, EBV nuclear proteins 2, 3, 4, and 6 genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	message	message	NOUN	NN	Number=Sing	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
16	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	EBV	EBV	VERB	VBP	Abbr=Yes|Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	6	6	NUM	CD	NumType=Card	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 181
# text = Electrophoretic mobility shift assays (EMSAs) demonstrated that the -300 region of the IL-1beta promoter, which contains a nuclear factor-kappaB (NF-kappaB) binding site, contained a functional RBP binding site.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	300	300	NUM	CD	NumType=Card	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
38	RBP	Rbp	PROPN	NNP	Number=Sing	_	_	_	_
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 182
# text = Binding of RBP to this site could be inhibited by addition of EBV nuclear proteins 3 and 6, suggesting that these proteins displace RBP from its recognition sequence, removing transcriptional repression and allowing gene transcription to occur.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	displace	displace	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	RBP	Rbp	PROPN	NNP	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	removing	remove	VERB	VBG	VerbForm=Ger	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
36	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 183
# text = In group I BL cells, containing low levels of NF-kappaB, only RBP binding was observed in EMSAs, whereas NF-kappaB binding could be demonstrated in EBV-transformed B cell lines containing high levels of activated NF-kappaB.
1	In	in	ADP	IN	_	_	_	_	_
2	group	group	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	BL	Bl	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	binding	binding	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
38	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
40	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 184
# text = In addition, the expression of latent membrane protein-1 led to activation of NF-kappaB that was capable of binding the IL-1beta promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
22	of	of	SCONJ	IN	_	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 185
# text = The study demonstrates that EBV can up-regulate IL-1beta expression, possibly by using RBP, NF-kappaB, or both.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	possibly	possibly	ADV	RB	_	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 186
# text = Copyright 1998 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1998	1998	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press	Press	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 187
# text = Document 00300256 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300256	00300256	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 188
# text = Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB.
1	Essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
5	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	intrapulmonary	intrapulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 189
# text = Acute inflammatory injury in rat lung induced by deposition of immunoglobulin G immune complexes requires expression of cytokines and chemokines as well as activation of the transcription factor nuclear factor (NF)-kappaB.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
6	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	deposition	deposition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
12	G	g	NOUN	NN	Number=Sing	_	_	_	_
13	immune	immune	PRON	PRP	_	_	_	_	_
14	complexes	complexe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 190
# text = There is little direct evidence regarding the role of alveolar macrophages in these activation events.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
11	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 191
# text = In the present studies, rat lungs were depleted of alveolar macrophages by airway instillation of liposome-encapsulated dichloromethylene diphosphonate.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
7	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
15	instillation	instillation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	liposome	liposome	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	encapsulated	encapsulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	dichloromethylene	dichloromethylene	NOUN	NN	Number=Sing	_	_	_	_
21	diphosphonate	diphosphonate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 192
# text = These procedures, which greatly reduced the number of retrievable alveolar macrophages, suppressed activation of lung NF-kappaB in the inflammatory model.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	procedures	procedure	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	greatly	greatly	ADV	RB	_	_	_	_	_
6	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	retrievable	retrievable	ADJ	JJ	Degree=Pos	_	_	_	_
11	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 193
# text = In addition, bronchoalveolar lavage levels of tumor necrosis factor-alpha (TNF-alpha) and the CXC chemokine, macrophage inflammatory protein-2, were substantially reduced.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	bronchoalveolar	bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
5	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CXC	CXC	PROPN	NNP	Number=Sing	_	_	_	_
21	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	substantially	substantially	ADV	RB	_	_	_	_	_
31	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 194
# text = In parallel, upregulation of the lung vascular adhesion molecule, intercellular adhesion molecule-1, was greatly reduced by intrapulmonary instillation of phosphonate-containing liposomes.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
8	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	greatly	greatly	ADV	RB	_	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	intrapulmonary	intrapulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
23	instillation	instillation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	phosphonate	phosphonate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
28	liposomes	liposome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 195
# text = Neutrophil accumulation and development of lung injury were also substantially diminished.
1	Neutrophil	Neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
2	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
7	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	substantially	substantially	ADV	RB	_	_	_	_	_
11	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 196
# text = Lung instillation of TNF-alpha in alveolar macrophage-depleted rats restored the NF-kappaB activation response in whole lung.
1	Lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
2	instillation	instillation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
9	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
13	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
22	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 197
# text = These data suggest that, in this inflammatory model, initial activation of NF-kappaB occurs in alveolar macrophages and the ensuing production of TNF-alpha may propagate NF-kappaB activation to other cell types in the lung.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
20	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ensuing	ensue	VERB	VBG	VerbForm=Ger	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	propagate	propagate	VERB	VB	VerbForm=Inf	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	types	type	NOUN	NNS	Number=Plur	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 198
# text = Document 00300258 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300258	00300258	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 199
# text = Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
15	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 200
# text = The class II trans-activator (CIITA) is a bi- or multi-functional domain protein which plays a critical role in the expression of MHC class II genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	bi	bi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	multi-functional	multi-functional	ADJ	JJ	Degree=Pos	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
28	class	class	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 201
# text = We report that removal of the N-terminal 151 amino acids, encompassing all of the acidic domain but leaving intact the proline/serine/threonine-rich domain, results in a mutant protein with potent suppressive properties for MHC class II expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	151	151	NUM	CD	NumType=Card	_	_	_	_
10	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
11	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	all	all	DET	DT	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
18	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	leaving	leave	VERB	VBG	VerbForm=Ger	_	_	_	_
21	intact	intact	ADV	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	proline	proline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	serine/threonine-rich	serine/threonine-rich	NOUN	NN	Number=Sing	_	_	_	_
26	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	results	result	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
35	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
36	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
39	class	class	NOUN	NN	Number=Sing	_	_	_	_
40	II	ii	NUM	CD	NumType=Card	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 202
# text = HeLa cells stably or transiently transfected with mutant CIITA constructs showed up to 99% suppression of MHC class II antigen induction by IFN-gamma and marked suppression of HLA-DRA mRNA expression.
1	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	transiently	transiently	ADV	RB	_	_	_	_	_
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
9	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
10	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	up	up	ADP	RP	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	99	99	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	%	%	SYM	NN	Number=Sing	_	_	_	_
16	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
34	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 203
# text = Transient transfection of a B lymphoma line resulted in up to 89% reduction of constitutive MHC class II expression within 5 days and suppression of HLA-DRA mRNA synthesis.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADV	RB	_	_	_	_	_
10	up	up	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	89	89	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	%	%	SYM	NN	Number=Sing	_	_	_	_
14	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	_
23	days	day	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
30	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
31	synthesis	synthesis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 204
# text = Document 00300264 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300264	00300264	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 205
# text = Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
6	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 206
# text = The macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
3	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 207
# text = However, the signaling events responsible for these effects remain unclear.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
5	events	event	NOUN	NNS	Number=Plur	_	_	_	_
6	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 208
# text = The present studies have examined the effects of M-CSF on potential signaling pathways involving expression of the jun and fos early response genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
22	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 209
# text = Low levels of c-jun transcripts were detectable in resting human peripheral blood monocytes.
1	Low	low	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 210
# text = Treatment of these cells with 10(3) units/ml human recombinant M-CSF was associated with rapid and transient increases in c-jun mRNA levels.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	units	unit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	ml	ml	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
15	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
23	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
27	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 211
# text = Nuclear run-on assays and mRNA stability studies demonstrated that M-CSF regulates c-jun expression by both an increase in transcription rate and a prolongation in the half-life of c-jun transcripts.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
8	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
9	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
10	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
15	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	_
16	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	prolongation	prolongation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	life	life	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 212
# text = M-CSF treatment was also associated with a rapid induction of the jun-B gene, although expression of this gene was prolonged compared to that of c-jun.
1	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-B	-b	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 213
# text = We further demonstrate that M-CSF increases c-fos mRNA levels in human monocytes through control at both the transcriptional and posttranscriptional levels.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
8	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
9	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	mRNA	mRNa	ADP	IN	_	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	control	control	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 214
# text = Maximal induction of the c-fos gene was followed by that for the fos-B gene.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 215
# text = Moreover, M-CSF-induced expression of the fos-related gene, fra-1, was delayed compared to that for both c-fos and fos-B.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	M-	M-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	fra	fra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
20	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 216
# text = Taken together, the results indicate that M-CSF treatment is associated with differential activation of multiple members of the jun/fos family and that expression of these genes could contribute to nuclear signaling mechanisms that regulate a specific program of monocyte differentiation.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
11	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	differential	differential	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
33	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	nuclear	nuclear	VERB	VB	VerbForm=Inf	_	_	_	_
36	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
37	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
42	program	program	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
45	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 217
# text = Document 00300280 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300280	00300280	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 218
# text = Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28. CD3, CD2, and CD28 are functionally distinct receptors on T lymphocytes.
1	Uncoupling	Uncoupl	VERB	VBG	VerbForm=Ger	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	HS1	Hs1	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
22	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
29	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CD28.	CD28.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n
32	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	functionally	functionally	ADV	RB	_	_	_	_	_
40	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
41	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 219
# text = Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn.
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	any	any	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	group	group	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	p85	p85	NUM	CD	NumType=Card	_	_	_	_
27	phosphoinositide	phosphoinositide	NOUN	NN	Number=Sing	_	_	_	_
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	Src	Src	ADJ	JJ	Degree=Pos	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
37	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	Fyn	Fyn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 220
# text = Ligation of CD3 also induces the tyrosine phosphorylation of HS1, a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function.
1	Ligation	Ligation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
16	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
21	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 221
# text = We have examined changes in HS1 phosphorylation after differential stimulation of CD3, CD2, and CD28 to elucidate its role in T cells and to further delineate the signaling pathways recruited by these receptors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	HS1	HS1	NUM	CD	NumType=Card	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	further	further	ADV	RB	_	_	_	_	_
28	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
32	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 222
# text = Unlike ligation of CD3, stimulation with anti-CD28 mAb or CHO cells expressing the CD28 ligands CD80 or CD86 did not lead to tyrosine phosphorylation of HS1 in Jurkat T cells.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
9	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	CHO	Cho	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
16	ligands	ligand	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	CD86	CD86	PROPN	NNP	Number=Sing	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	tyrosine	tyrosine	VERB	VB	VerbForm=Inf	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 223
# text = Additionally, no tyrosine phosphorylation of HS1 was induced by mitogenic pairs of anti-CD2 mAbs capable of activating the transcription factor NFAT (nuclear factor of activated T cells).
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HS1	Hs1	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
12	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
15	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
16	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	SCONJ	IN	_	_	_	_	_
18	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 224
# text = Costimulation through CD28 and/or CD2 did not modulate the CD3-dependent phosphorylation of HS1.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	or	or	CCONJ	CC	_	_	_	_	_
7	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 225
# text = In vivo studies indicated that CD3-induced HSI phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphatase CD45, did not require MEK1 kinase activity, and was regulated by protein kinase C activation.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	HSI	HSI	NUM	CD	NumType=Card	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	upon	upon	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Src	Src	ADJ	JJ	Degree=Pos	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	Lck	Lck	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
24	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
29	MEK1	MEK1	NUM	CD	NumType=Card	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	C	c	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 226
# text = Thus, although CD3, CD28, and CD2 activate many of the same signaling molecules, they differed in their capacity to induce the tyrosine phosphorylation of HSI.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
10	activate	activate	NOUN	NN	Number=Sing	_	_	_	_
11	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
19	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HSI	HSI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 227
# text = Furthermore, activation-dependent tyrosine phosphorylation of HS1 was not required for NFAT transcriptional activation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HS1	Hs1	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 228
# text = Document 00300283 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300283	00300283	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 229
# text = Cytokine rescue from glucocorticoid induced apoptosis in T cells is mediated through inhibition of IkappaBalpha.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	_
2	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 230
# text = We previously reported that dexamethasone (DEX), a synthetic glucocorticoid, causes apoptosis in mature
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
12	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 231
# text = Th cell lines, and that this induction of cell death is prevented by specific cytokines, namely, by IL-2 in Th1 cells and by IL-4 in Th2 cells.
1	Th	th	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	death	death	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	namely	namely	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 232
# text = We now show that this differential rescue by specific cytokines in Th cells correlates with the level of IkappaBalpha that is regulated by DEX and cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	differential	differential	NOUN	NN	Number=Sing	_	_	_	_
7	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Th	th	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	DEX	Dex	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 233
# text = In both cell types the cellular levels of IkappaBalpha mRNA and protein were evaluated by DEX treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	DEX	Dex	PROPN	NNP	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 234
# text = Interestingly, the DEX-mediated IkappaBalpha induction was completely inhibited by IL-2, but not IL-4, in Th1 cells, while the reverse profile was seen in Th2 cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	completely	completely	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
30	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 235
# text = In both cell types, the cytokine that inhibits the induction of IkappaBalpha by DEX, also rescues these cells from DEX-induced apoptosis, although the rescue cytokine is different in Th1 and Th2 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	rescues	rescue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	although	although	SCONJ	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
30	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 236
# text = Our results imply that T cells need to maintain a certain level of NF-kappaB transcriptional activity in order to survive; up- or down-regulation of nuclear NF kappaB through modulation of IkappaBalpha expression by cytokines or DEX may lead to cell survival or cell death, respectively.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	need	need	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	order	order	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	through	through	ADP	IN	_	_	_	_	_
35	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	_
43	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
44	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
47	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
48	or	or	CCONJ	CC	_	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 237
# text = Document 00300291 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300291	00300291	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 238
# text = Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer.
1	Tissue-	Tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
7	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 239
# text = The 15-lipoxygenase (lox) gene is expressed in a tissue-specific manner, predominantly in erythroid cells but also in airway epithelial cells and eosinophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	lox	lox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	tissue-	tissue-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	predominantly	predominantly	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	airway	airway	ADJ	JJ	Degree=Pos	_	_	_	_
25	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 240
# text = We demonstrate in this report that the 5' flanking DNA of the 15-lox gene contains sequences which down-regulate its activity in a variety of non-erythroid cell lines but not in two erythroid cell lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	_
10	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	lox	lox	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	two	two	NUM	CD	NumType=Card	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 241
# text = The element has characteristics of a transcriptional 'silencer' since it functions in both orientations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
9	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	'	'	PUNCT	''	_	_	_	_	_
11	since	since	SCONJ	IN	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	orientations	orientation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 242
# text = The main activity of the silencer has been mapped to the first 900 bp of 5' flanking DNA, which contains nine binding sites for a nuclear factor present in non-erythroid cells but not in erythroid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	900	900	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'	'	PUNCT	``	_	_	_	_	_
18	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	nine	nine	NUM	CD	NumType=Card	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 243
# text = These binding sites have similar sequences and multiple copies of the binding sites confer tissue-specific down-regulation when attached to a minimal lox promoter fragment.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	confer	confer	NOUN	NN	Number=Sing	_	_	_	_
15	tissue-	tissue-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	attached	attach	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
25	lox	lox	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 244
# text = The 5' flanking DNA also contains a cluster of three binding sites for the GATA family of transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	PUNCT	``	_	_	_	_	_
4	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	three	three	NUM	CD	NumType=Card	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 245
# text = Document 00300292 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300292	00300292	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 246
# text = Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 247
# text = Activation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 248
# text = The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	point	point	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 249
# text = The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	named	name	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CD28RE	CD28RE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	target	target	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 250
# text = The CD28RE sequence reveals similarity to the consensus kappaB binding motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
5	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
9	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 251
# text = Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD28RE	Cd28re	PRON	EX	_	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	approximately	approximately	ADV	RB	_	_	_	_	_
16	35	35	NUM	CD	NumType=Card	_	_	_	_
17	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
18	called	call	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	clearly	clearly	ADV	RB	_	_	_	_	_
35	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	_
41	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
44	family	family	NOUN	NN	Number=Sing	_	_	_	_
45	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 252
# text = Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	de	de	NOUN	NN	Number=Sing	_	_	_	_
12	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=1|Tense=Past|VerbForm=Fin	_	_	_	_
17	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	received	receive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	necessarily	necessarily	ADV	RB	_	_	_	_	_
33	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
34	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
35	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 253
# text = Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35.
1	Nonmitogenic	Nonmitogenic	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 254
# text = These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 255
# text = Similar to its effect on IL-2 production, cyclosporin
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 256
# text = A inhibited the induction of NF-MATp35.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 257
# text = Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	_
15	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	excellent	excellent	ADJ	JJ	Degree=Pos	_	_	_	_
17	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
28	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
29	among	among	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
32	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	control	control	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 258
# text = Document 00300298 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300298	00300298	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 259
# text = Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Cdk	Cdk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 260
# text = The functions of basic helix-loop-helix (bHLH) transcription factors in activating differentiation-linked gene expression and in inducing G1 cell cycle arrest are negatively regulated by members of the Id family of HLH proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
5	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	bHLH	bHLH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	G1	G1	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
26	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	negatively	negatively	ADV	RB	_	_	_	_	_
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	Id	id	PROPN	NNP	Number=Sing	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	HLH	Hlh	DET	DT	_	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 261
# text = These bHLH antagonists are induced during a mitogenic signalling response, and they function by sequestering their bHLH targets in inactive heterodimers that are unable to bind to specific gene regulatory (E box) sequences.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	bHLH	bhlh	ADJ	JJ	Degree=Pos	_	_	_	_
3	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
14	function	function	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	sequestering	sequester	VERB	VBG	VerbForm=Ger	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
19	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	E	e	NOUN	NN	Number=Sing	_	_	_	_
34	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 262
# text = Recently, cyclin E-Cdk2- and cyclin A-Cdk2-dependent phosphorylation of a single conserved serine residue (Ser5) in Id2 has been shown to occur during late G1-to-S phase transition of the cell cycle, and this neutralizes the function of Id2 in abrogating E-box-dependent bHLH homo- or heterodimer complex formation in vitro (E.Hara, M.Hall, and G.Peters, EMBO J.16:332-342, 1997).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
4	E-	e-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	Cdk2	cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
9	A-Cdk2	A-Cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
16	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
18	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	Ser5	Ser5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Id2	id2	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
31	G1	g1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	S	s	NOUN	NN	Number=Sing	_	_	_	_
36	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
37	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
45	neutralizes	neutralize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	function	function	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	Id2	Id2	NUM	CD	NumType=Card	_	_	_	_
50	in	in	SCONJ	IN	_	_	_	_	_
51	abrogating	abrogat	VERB	VBG	VerbForm=Ger	_	_	_	_
52	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
56	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
57	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	,	_	_	_	_	_
59	or	or	CCONJ	CC	_	_	_	_	_
60	heterodimer	heterodimer	ADJ	JJR	Degree=Cmp	_	_	_	_
61	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
62	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	E.Hara	E.Hara	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	M.Hall	M.Hall	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	G.Peters	G.Peters	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	EMBO	EMBO	PROPN	NNP	Number=Sing	_	_	_	_
74	J.16:332-342	J.16:332-342	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	1997	1997	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
77	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 263
# text = We now show that an analogous cell-cycle-regulated phosphorylation of Id3 alters the specificity of Id3 for abrogating both E-box-dependent bHLH homo- or heterodimer complex formation in vitro and E-box-dependent reporter gene function in vivo.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cycle-regulated	cycle-regulated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
13	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	SCONJ	IN	_	_	_	_	_
19	abrogating	abrogat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
26	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	heterodimer	heterodimer	ADJ	JJR	Degree=Cmp	_	_	_	_
30	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
31	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	function	function	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 264
# text = Furthermore, compared with wild-type Id3, an Id3 Asp5 mutant (mimicking phosphorylation) is unable to promote cell cycle S phase entry in transfected fibroblasts, whereas an Id3 Ala5 mutant (ablating phosphorylation) displays an activity significantly greater than that of wild-type Id3 protein.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
12	Asp5	asp5	NOUN	NN	Number=Sing	_	_	_	_
13	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	mimicking	mimicking	NOUN	NN	Number=Sing	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
24	S	's	PART	POS	_	_	_	_	_
25	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
26	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
34	Ala5	ala5	NOUN	NN	Number=Sing	_	_	_	_
35	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	ablating	ablat	VERB	VBG	VerbForm=Ger	_	_	_	_
38	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	significantly	significantly	ADV	RB	_	_	_	_	_
44	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
45	than	than	ADP	IN	_	_	_	_	_
46	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	type	type	NOUN	NN	Number=Sing	_	_	_	_
51	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
52	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 265
# text = Cdk2-dependent phosphorylation therefore provides a switch during late G1-to-S phase that both nullifies an early G1 cell cycle regulatory function of Id3 and modulates its target bHLH specificity.
1	Cdk2	Cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	_
6	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
11	G1	G1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	S	S	NOUN	NN	Number=Sing	_	_	_	_
16	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	both	both	ADV	RB	_	_	_	_	_
19	nullifies	nullify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
22	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	target	target	NOUN	NN	Number=Sing	_	_	_	_
33	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
34	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 266
# text = These data also demonstrate that the ability of Id3 to promote cell cycle S phase entry is not simply a function of its ability to modulate bHLH heterodimer-dependent gene expression and establish a biologically important mechanism through which Cdk2 and
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
14	S	's	PART	POS	_	_	_	_	_
15	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
16	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	simply	simply	ADV	RB	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	bHLH	bHLH	DET	DT	_	_	_	_	_
28	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	biologically	biologically	ADV	RB	_	_	_	_	_
37	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
38	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
39	through	through	ADP	IN	_	_	_	_	_
40	which	which	PRON	WDT	PronType=Rel	_	_	_	_
41	Cdk2	Cdk2	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_

# sent_id = 267
# text = Id-bHLH functions are integrated in the coordination of cell proliferation and differentiation.
1	Id	id	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
4	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 268
# text = Document 003002100 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002100	003002100	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 269
# text = Molecular and cellular analysis of human immunodeficiency virus-induced apoptosis in lymphoblastoid T-cell-line-expressing wild-type and mutated CD4 receptors.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	mutated	mutate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 270
# text = We have previously shown that the presence of the CD4 cytoplasmic tail is critical for human immunodeficiency virus (HIV)-induced apoptosis (J.Corbeil, M.Tremblay, and D.D.Richman, J.Exp.Med.183:39-48, 1996).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
11	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
12	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	J.Corbeil	J.Corbeil	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	M.Tremblay	M.Tremblay	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	D.D.Richman	D.D.Richman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	J.Exp.Med	J.Exp.Med	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.183:39-48	.183:39-48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	1996	1996	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 271
# text = We have pursued our investigation of the role of the CD4 transduction pathway in HIV-induced apoptosis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	pursued	pursue	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 272
# text = To do this, wild-type and mutant forms of the CD4 cytoplasmic tail were stably expressed in the lymphoblastoid T-cell line A2.01.
1	To	to	PART	TO	_	_	_	_	_
2	do	do	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
10	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
14	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
15	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	stably	stably	ADV	RB	_	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	_
25	A2.01	a2.01	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 273
# text = Apoptosis was prevented when CD4 truncated at residue 402 was expressed; however, cells expressing mutated receptors that do not associate with p56(lck) (mutated at the dicysteine motif and truncated at residue 418) but which conserved proximal domains of the cytoplasmic tail underwent apoptosis like wild- type CD4.
1	Apoptosis	Apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	when	when	ADV	WRB	PronType=Int	_	_	_	_
5	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
6	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
9	402	402	NUM	CD	NumType=Card	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
17	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	dicysteine	dicysteine	NOUN	NN	Number=Sing	_	_	_	_
33	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
38	418	418	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	which	which	PRON	WDT	PronType=Int	_	_	_	_
42	conserved	conserve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
44	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
48	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
49	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
50	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
51	like	like	ADP	IN	_	_	_	_	_
52	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	_
54	type	type	NOUN	NN	Number=Sing	_	_	_	_
55	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 274
# text = The differences between wild-type and mutated receptors in the induction of apoptosis were not related to levels of p56(lck) or NF- kappaB activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	_
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 275
# text = Initial signaling through the CD4 receptor played a major role in the sensitization of HIV-infected T cells to undergo apoptosis.
1	Initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	played	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	sensitization	sensitization	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	undergo	undergo	VERB	VB	VerbForm=Inf	_	_	_	_
21	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 276
# text = Incubation of HIV-infected cells with monoclonal antibody (MAb) 13B8-2, which binds to CD4 in a region critical for dimerization of the receptor, prevented apoptosis without inhibiting HIV replication.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
8	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	MAb	MAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	13B8	13B8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
32	without	without	SCONJ	IN	_	_	_	_	_
33	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
35	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 277
# text = Moreover, the apoptotic process was not related to Fas-Fas ligand interaction; however, an antagonistic anti-Fas MAb (ZB-4) enhanced apoptosis in HIV-infected cells without inducing apoptosis in uninfected cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
5	process	process	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
14	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
20	anti-Fas	anti-Fas	PROPN	NNPS	Number=Plur	_	_	_	_
21	MAb	MAb	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ZB	ZB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	without	without	SCONJ	IN	_	_	_	_	_
34	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
35	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 278
# text = These observations demonstrate that CD4 signaling mediates HIV-induced apoptosis by a mechanism independent of Fas-Fas ligand interaction, does not require p56(lck) signaling, and may involve a critical region for CD4 dimerization.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
6	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
7	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
8	HIV-	HIV-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
25	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	signaling	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
36	region	region	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
39	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 279
# text = Document 003002101 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002101	003002101	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 280
# text = Characterization of the human elk-1 promoter.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 281
# text = Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes.
1	Potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
6	intronic	intronic	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 282
# text = To characterize the human elk-1 promoter, we mapped the transcriptional start site and isolated elk-1-specific genomic phage clones that contained extensive upstream and downstream sequences.
1	To	to	PART	TO	_	_	_	_	_
2	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	start	start	NOUN	NN	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
23	phage	phage	NOUN	NN	Number=Sing	_	_	_	_
24	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
28	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
31	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 283
# text = A TATA-like motif was identified immediately upstream of the transcriptional start site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	TATA	TATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
5	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	immediately	immediately	ADV	RB	_	_	_	_	_
9	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	start	start	NOUN	NN	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 284
# text = Functional analyses of DNA fragments containing the TATA element and the identification of a DNase I-hypersensitive chromatin site (HS 1) in close proximity to the TATA box suggest that the identified TATA motif is important for elk-1 transcription in vivo.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HS	h	PROPN	NNP	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
27	proximity	proximity	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	_
31	box	box	NOUN	NN	Number=Sing	_	_	_	_
32	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	identified	identified	ADJ	JJ	Degree=Pos	_	_	_	_
36	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
37	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 285
# text = Sequences upstream and downstream from the TATA box were found to contribute to elk-1 promoter activity.
1	Sequences	Sequences	NOUN	NNS	Number=Plur	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	elk	elk	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 286
# text = A second hypersensitive site (HS 2) was identified within the first intron in pre-monocytic cells, which express Elk-1 only when differentiating to monocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HS	HS	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	pre-monocytic	pre-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
21	Elk	elk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	when	when	ADV	WRB	PronType=Int	_	_	_	_
26	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 287
# text = In a variety of other cell types, which display a constitutive Elk-1 expression, HS 2 did not exist, suggesting that inducibility of elk-1 expression is associated with the presence of HS 2. Egr-1 and the serum response factor were found to interact specifically with the intronic sequence at +265 and +448, respectively.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	display	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
13	Elk	elk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_
41	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-1	-1	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
48	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	to	to	PART	TO	_	_	_	_	_
51	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
52	specifically	specifically	ADV	RB	_	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	intronic	intronic	ADJ	JJ	Degree=Pos	_	_	_	_
56	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
57	at	at	ADP	IN	_	_	_	_	_
58	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
59	265	265	NUM	CD	NumType=Card	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
62	448	448	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 288
# text = Because Egr-1 mRNA and protein levels were observed to increase significantly before induction of elk-1 expression, we propose that Egr-1 is important for the regulation of elk-1 transcription in differentiating monocytes.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	significantly	significantly	ADV	RB	_	_	_	_	_
13	before	before	ADP	IN	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-1	-1	NUM	CD	NumType=Card	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	differentiating	differentiat	ADJ	JJ	Degree=Pos	_	_	_	_
38	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 289
# text = Document 003002102 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002102	003002102	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 290
# text = Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	thrombin-	thrombin-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 291
# text = BACKGROUND: Activated platelets tether and activate myeloid leukocytes.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	tether	tether	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
9	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 292
# text = To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
5	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
12	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	AMI	Ami	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	occurrence	occurrence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
33	conjugates	conjugate	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 293
# text = METHODS AND RESULTS:
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 294
# text = We obtained peripheral venous blood samples in 20 patients with AMI before and daily for 5 days after direct percutaneous transluminal coronary angioplasty (PTCA) and in 20 patients undergoing elective PTCA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	venous	venous	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	_
12	before	before	ADV	RB	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	daily	daily	ADV	RB	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	days	day	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
20	percutaneous	percutaneous	ADJ	JJ	Degree=Pos	_	_	_	_
21	transluminal	transluminal	ADJ	JJ	Degree=Pos	_	_	_	_
22	coronary	coronary	NOUN	NN	Number=Sing	_	_	_	_
23	angioplasty	angioplasty	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PTCA	PTCA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	20	20	NUM	CD	NumType=Card	_	_	_	_
30	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
31	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
32	elective	elective	ADJ	JJ	Degree=Pos	_	_	_	_
33	PTCA	PTCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 295
# text = Throughout the study period, CD41 immunofluorescence of leukocytes (flow cytometry) revealed increased leukocyte-platelet adhesion in patients with AMI compared with control patients (mean +/- SE of fluorescence [channels] before PTCA: 77 +/- 16 versus 35 +/- 9; P = .003).
1	Throughout	throughout	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	period	period	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	CD41	CD41	NUM	CD	NumType=Card	_	_	_	_
7	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
12	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	control	control	NOUN	NN	Number=Sing	_	_	_	_
27	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	mean	mean	X	GW	_	_	_	_	_
30	+/-	+/-	X	GW	_	_	_	_	_
31	SE	se	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
34	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	]	]	PUNCT	-RRB-	_	_	_	_	_
37	before	before	ADP	IN	_	_	_	_	_
38	PTCA	PTCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	:	:	PUNCT	:	_	_	_	_	_
40	77	77	NUM	CD	NumType=Card	_	_	_	_
41	+/-	+/-	SYM	SYM	_	_	_	_	_
42	16	16	NUM	CD	NumType=Card	_	_	_	_
43	versus	versus	ADP	IN	_	_	_	_	_
44	35	35	NUM	CD	NumType=Card	_	_	_	_
45	+/-	+/-	SYM	SYM	_	_	_	_	_
46	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	P	p	NOUN	NN	Number=Sing	_	_	_	_
49	=	=	SYM	SYM	_	_	_	_	_
50	.003	.003	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 296
# text = In vitro, thrombin-stimulated fixed platelets bound to neutrophils and monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	thrombin-	thrombin-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 297
# text = Within 2 hours, this resulted in increased mRNA for interleukin (IL),1 beta, IL-8, and monocyte chemoattractant protein (MCP)-1 in unfractionated leukocytes.
1	Within	within	ADP	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,1	,1	NUM	CD	NumType=Card	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
24	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	unfractionated	unfractionated	ADJ	JJ	Degree=Pos	_	_	_	_
33	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 298
# text = After 4 hours, IL-1 beta and IL-8 concentration of the cell-free supernatant had increased by 268 +/- 36% and 210 +/- 7%, respectively, and cellular MCP-1 content had increased by 170 +/- 8%.
1	After	after	ADP	IN	_	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
19	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
20	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	268	268	NUM	CD	NumType=Card	_	_	_	_
24	+/-	+/-	SYM	SYM	_	_	_	_	_
25	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	210	210	NUM	CD	NumType=Card	_	_	_	_
29	+/-	+/-	SYM	SYM	_	_	_	_	_
30	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
37	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	content	content	NOUN	NN	Number=Sing	_	_	_	_
41	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	170	170	NUM	CD	NumType=Card	_	_	_	_
45	+/-	+/-	SYM	SYM	_	_	_	_	_
46	8%	8%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 299
# text = Addition of activated platelets to adherent monocytes had a similar effect and was associated with nuclear factor-kappa B activation.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 300
# text = Inhibition of binding by anti-P selectin antibodies reduced the effect of activated platelets on cytokine production.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	SCONJ	IN	_	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
6	-P	-p	ADJ	JJ	Degree=Pos	_	_	_	_
7	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 301
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 302
# text = In patients with AMI, leukocyte-platelet adhesion is increased.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 303
# text = Binding of activated platelets induces IL-1 beta, IL-8, and MCP-1 in leukocytes.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 304
# text = Our findings suggest that leukocyte-platelet adhesion contributes to the regulation of inflammatory responses in AMI.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 305
# text = Document 003002116 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002116	003002116	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 306
# text = Paternal expression of WT1 in human fibroblasts and lymphocytes.
1	Paternal	Paternal	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 307
# text = The Wilms' tumor suppressor gene ( WT1 ) was previously identified as being imprinted, with frequent maternal expression in human placentae and fetal brains.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Wilms	Wilm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	'	's	PART	POS	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	_
8	WT1	wt1	PROPN	NNP	Number=Sing	_	_	_	_
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
15	imprinted	imprinted	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	frequent	frequent	ADJ	JJ	Degree=Pos	_	_	_	_
19	maternal	maternal	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	placentae	placenta	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
26	brains	brain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 308
# text = We examined the allele-specific expression of WT1 in cultured human fibroblasts from 15 individuals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	WT1	WT1	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	15	15	NUM	CD	NumType=Card	_	_	_	_
16	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 309
# text = Seven of 15 fibroblast lines were heterozygous for polymorphic alleles, and the expression patterns were variable, i.e., equal, unequal or monoallelic paternal expression in three, two and two cases, respectively.
1	Seven	Seven	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	15	15	NUM	CD	NumType=Card	_	_	_	_
4	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
10	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	unequal	unequal	ADJ	JJ	Degree=Pos	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
26	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	two	two	NUM	CD	NumType=Card	_	_	_	_
34	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 310
# text = Exclusive paternal expression of WT1 was also shown in non-cultured peripheral lymphocytes from the latter two individuals.
1	Exclusive	Exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
2	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	non-cultured	non-cultured	ADJ	JJ	Degree=Pos	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 311
# text = The allele-specific expression profiles of other imprinted genes, IGF2 and H19, on human chromosome 11 were constant and consistent with those in other tissues.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	imprinted	imprint	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	IGF2	Igf2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	H19	h19	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
19	11	11	NUM	CD	NumType=Card	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 312
# text = Our unexpected observations of paternal or biallelic expression of WT1 in fibroblasts and lymphocytes, together with the previous findings of maternal or biallelic expression in placentae and brains, suggest that the allele-specific regulatory system of WT1 is unique and may be controlled by a putative tissue- and individual-specific modifier.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	unexpected	unexpected	ADJ	JJ	Degree=Pos	_	_	_	_
3	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	biallelic	biallelic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	together	together	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
20	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	maternal	maternal	ADJ	JJ	Degree=Pos	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	biallelic	biallelic	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	placentae	placenta	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	brains	brains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
38	system	system	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
45	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
46	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
50	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	,	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
56	modifier	modifier	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 313
# text = Document 003002117 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002117	003002117	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 314
# text = Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B. Stimulation of highly purified human T-cells via CD2 and CD28 adhesion molecules induces and maintains proliferation for more than 3 weeks.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
9	plus	plus	CCONJ	CC	_	_	_	_	_
10	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
13	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	term	term	NOUN	NN	Number=Sing	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
24	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	highly	highly	ADV	RB	_	_	_	_	_
27	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	via	via	ADP	IN	_	_	_	_	_
32	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	CD28	Cd28	NUM	CD	NumType=Card	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
37	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	maintains	maintain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
43	than	than	ADP	IN	_	_	_	_	_
44	3	3	NUM	CD	NumType=Card	_	_	_	_
45	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 315
# text = This potent interleukin 2 (IL-2)-dependent activation does not require monocytes or accessory cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 316
# text = Long-lasting IL-2 receptivity is associated with high-level expression of the inducible IL-2 receptor alpha chain (IL-2R alpha) gene that is regulated at both transcriptional and posttranscriptional levels.
1	Long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	lasting	last	VERB	VBG	VerbForm=Ger	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	receptivity	receptivity	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	both	both	CCONJ	CC	_	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 317
# text = Increase of IL-2R alpha gene transcription involves the enhanced binding of the transcription factor NF-kappa B to its consensus sequence in the 5'-regulatory region of the IL-2R alpha gene.
1	Increase	increase	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
37	alpha	alpha	ADP	IN	_	_	_	_	_
38	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 318
# text = To dissect the molecular basis for the unusually persistent transcription of the IL-2R alpha gene, we analyzed nuclear NF-kappa B binding to a radiolabeled IL-2R alpha kappa B-specific oligonucleotide probe during the time course of CD2 + CD28 activation.
1	To	to	PART	TO	_	_	_	_	_
2	dissect	dissect	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	unusually	unusually	ADJ	JJ	Degree=Pos	_	_	_	_
9	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	radiolabeled	radiolabel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
33	alpha	alpha	ADP	IN	_	_	_	_	_
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
39	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
40	during	during	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	time	time	NOUN	NN	Number=Sing	_	_	_	_
43	course	course	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
46	+	+	SYM	SYM	_	_	_	_	_
47	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 319
# text = Resting T-cell nuclear extracts contained KBF1/p50 homodimer.
1	Resting	reste	NOUN	NN	Number=Sing	_	_	_	_
2	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	p50	p50	NUM	CD	NumType=Card	_	_	_	_
10	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 320
# text = After stimulation, two new kappa B-specific complexes were identified as NF-kappa B p50-p65 heterodimer and putative c-Rel homodimer or c-Rel-p65 heterodimer.
1	After	after	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	p65	p65	NUM	CD	NumType=Card	_	_	_	_
20	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
23	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	Rel	Rel	ADJ	JJ	Degree=Pos	_	_	_	_
25	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	p65	p65	NUM	CD	NumType=Card	_	_	_	_
32	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 321
# text = Both inducible complexes persisted for at least 3 weeks.
1	Both	both	DET	DT	_	_	_	_	_
2	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
3	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
4	persisted	persist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	at	at	ADV	RB	_	_	_	_	_
7	least	least	ADV	RBS	Degree=Sup	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 322
# text = Their relative levels were very similar for the duration of proliferation.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	very	very	ADV	RB	_	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 323
# text = In parallel, CD2 + CD28 activation triggered a significant intracellular thiol decrease, suggesting that oxygen radicals are involved in the signaling pathway of adhesion molecules.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
5	+	+	SYM	SYM	_	_	_	_	_
6	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	triggered	trigger	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	_
13	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
18	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
24	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 324
# text = Finally, micromolar amounts of pyrrolidine dithiocarbamate, an oxygen radical scavenger that efficiently blocked the nuclear appearance of NF-kappa B in T-lymphocytes, also inhibited IL-2 secretion, IL-2R alpha cell surface expression, and T-cell proliferation.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	micromolar	micromolar	ADJ	JJ	Degree=Pos	_	_	_	_
4	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
7	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
11	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
12	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	efficiently	efficiently	ADV	RB	_	_	_	_	_
15	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 325
# text = Together, these results suggest that NF-kappa B plays an important role in long-term activation of human primary T-lymphocytes via CD2 + CD28.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	term	term	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	via	via	ADP	IN	_	_	_	_	_
26	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
27	+	+	SYM	SYM	_	_	_	_	_
28	CD28	CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 326
# text = Document 003002118 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002118	003002118	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 327
# text = Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway.
1	Overproduction	Overproduction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	lyt	lyt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-activation	-activation	NOUN	NN	Number=Sing	_	_	_	_
25	via	via	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
32	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 328
# text = Molecular, biochemical and epidemiological evidence implicate HTLV-I as an etiologic agent of adult T cell leukemia (ATL).
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	epidemiological	epidemiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	implicate	implicate	ADJ	JJ	Degree=Pos	_	_	_	_
8	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
14	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
19	leukemia	leukemia	PROPN	NNP	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 329
# text = The Tax protein of HTLV-I, a positive transcriptional activator of HTLV-I gene expression, is a viral oncogene that also increases transcription of cellular genes including GM-CSF, IL-2R alpha and IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
39	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 330
# text = One of the cellular targets of the trans-activating effects of Tax is the NF-kappa B/Rel family of transcription factors, pleiotropic regulators of immunoregulatory, cytokine and viral gene expression.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 331
# text = In this report, we demonstrate that NFKB2 (lyt-10) and c-Rel are overexpressed in HTLV-I infected and Tax-expressing cells and, together, account for the majority of the constitutive NF-kappa B binding activity in these cells before and after PMA stimulation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	lyt	lyt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	infected	infect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	account	account	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
41	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	before	before	ADP	IN	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	after	after	ADP	IN	_	_	_	_	_
53	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 332
# text = Most importantly, we show a Tax-dependent correlation between expression of NFKB2(p100) and processing to the DNA binding NFKB2(p52) form, induction of c-Rel, and trans-activation of NF-kappa B-mediated gene expression.
1	Most	most	ADV	RBS	_	_	_	_	_
2	importantly	importantly	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	processing	process	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 333
# text = Furthermore, the NFKB2 precursor is physically associated with c-Rel and with Tax in HTLV-I infected cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	_
5	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	physically	physically	ADV	RB	_	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 334
# text = We propose that NFKB2 synthesis and processing allows continuous nuclear expression of an otherwise cytoplasmic protein and, in conjunction with overexpression of c-Rel, NFKB2 alters the NF-kappa B signalling pathway and contributes to leukemic transformation of T cells by HTLV-I.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NFKB2	Nfkb2	NUM	CD	NumType=Card	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
8	allows	allow	NOUN	NNS	Number=Plur	_	_	_	_
9	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	otherwise	otherwise	ADV	RB	_	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	_
29	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
36	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
41	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 335
# text = Document 003002124 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002124	003002124	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 336
# text = Abnormal regulation of the IL-2 promoter in lpr CD4-CD8- T lymphocytes results in constitutive expression of a novel nuclear factor of activated T cells-binding factor.
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lpr	lpr	ADJ	JJ	Degree=Pos	_	_	_	_
11	CD4-CD8	CD4-CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 337
# text = The inert quality of MRL-Ipr/Ipr (Ipr) peripheral CD4-CD8- (CD4-8-) T cells manifests primarily as an inability to proliferate or produce IL-2 in response to TCR or mitogenic stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inert	inert	ADJ	JJ	Degree=Pos	_	_	_	_
3	quality	quality	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	MRL	MRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	CD4-CD8	Cd4-cd8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8-)	8-)	SYM	NFP	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	manifests	manifest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	primarily	primarily	ADV	RB	_	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
40	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 338
# text = Yet these same cells do initiate early TCR-mediated signaling events, such as generation of inositol phosphates and increased intracellular calcium.
1	Yet	yet	CCONJ	CC	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
7	early	early	ADV	RB	Degree=Pos	_	_	_	_
8	TCR	TCR	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	inositol	inositol	ADJ	JJ	Degree=Pos	_	_	_	_
19	phosphates	phosphate	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 339
# text = They also display constitutively high levels of p59fyn and CD3 zeta tyrosine phosphorylation.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p5	p5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	9fyn	9fyn	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
12	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 340
# text = The generation of second messengers in T cells normally leads to downstream signaling that results in transcriptional activation of the IL-2 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	normally	normally	ADV	RB	_	_	_	_	_
10	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	downstream	downstream	VERB	VB	VerbForm=Inf	_	_	_	_
13	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 341
# text = We, therefore, compared the activation state of the IL-2 gene promoter region in freshly isolated and stimulated Ipr CD4-8- T cells with that of normal T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	state	state	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	freshly	freshly	ADV	RB	_	_	_	_	_
19	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	T	t	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	T	PROPN	NNP	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 342
# text = Levels of the octamer, NF-kappa B (p50-p65 heterodimer), and AP-1 transcriptional factors are constitutively elevated in freshly isolated Ipr CD4-8- T cells, consistent with the activated phenotype of these cells.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	B	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	freshly	freshly	ADV	RB	_	_	_	_	_
28	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
30	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	T	t	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 343
# text = Upon stimulation with mitogens, formation of the transactivating complex, nuclear factor of activated T cells (NF-AT), occurs with normal kinetics in Ipr CD4-8- T cells.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transactivating	transactivating	VERB	VBG	VerbForm=Ger	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
30	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	T	t	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 344
# text = Yet, the levels of the activating NF-AT complex never reach those observed in similarly stimulated normal T cells.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	never	never	ADV	RB	_	_	_	_	_
13	reach	reach	VERB	VB	VerbForm=Inf	_	_	_	_
14	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADV	RB	_	_	_	_	_
17	similarly	similarly	ADV	RB	_	_	_	_	_
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 345
# text = Furthermore, nuclear extracts from Ipr CD4-8- T cells display high levels of a novel specific binding activity at the NF-AT site, which is present at much lower levels in freshly isolated normal T lymphocytes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	_
10	T	t	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	much	much	ADV	RB	_	_	_	_	_
33	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	freshly	freshly	ADV	RB	_	_	_	_	_
37	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
39	T	t	NOUN	NN	Number=Sing	_	_	_	_
40	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 346
# text = Upon mitogenic stimulation, the binding activity of the novel NF-AT-binding factor is rapidly down-regulated in normal T cells, but persists at high levels in Ipr CD4-8- T cells.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	novel	novel	PROPN	NNP	Number=Sing	_	_	_	_
11	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	AT	At	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	rapidly	rapidly	ADV	RB	_	_	_	_	_
19	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	persists	persist	NOUN	NNS	Number=Plur	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
34	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	_
37	T	t	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 347
# text = These two abnormalities at the NF-AT site provide a potential mechanism to account for the defect in IL-2 production from Ipr CD4-8- T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
26	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	_
29	T	t	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 348
# text = Document 003002127 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002127	003002127	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 349
# text = IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-kappaB induction and IL-2 receptor alpha expression.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
12	prolymphocytic	prolymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 350
# text = The binding of interleukin-2 (IL-2) to its receptor on normal T cells induces nuclear expression of nuclear factor kappaB (NF-kappaB), activation of the IL-2 receptor (IL-2R) alpha chain gene, and cell proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2R	2r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
45	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 351
# text = In the present study, the role of IL-2R signaling in the growth of CD8+ T cell prolymphocytic leukemia (T-PLL) cells has been investigated.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	R	be	X	GW	_	_	_	_	_
13	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	T	t	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	prolymphocytic	prolymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	T	t	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	PLL	pLl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 352
# text = Flow cytometry revealed that primary leukemia cells from a patient with CD8+ T-PLL expressed IL-2Ralpha and beta chains, and the cells showed a proliferative response and an increase in IL-2Ralpha expression on culture with exogeneous IL-2.
1	Flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	T	t	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	PLL	pLl	NOUN	NN	Number=Sing	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	Ralpha	Ralpha	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	chains	chains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	exogeneous	exogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
46	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 353
# text = Northern blot analysis failed to detect IL-2 mRNA, suggesting that IL-2 may act in a paracrine manner in vivo.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	paracrine	paracrine	NOUN	NN	Number=Sing	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 354
# text = Electrophoretic mobility-shift assays revealed that recombinant IL-2 increased NF-kappaB binding activity in nuclear extracts of the leukemia cells, and Northern blot analysis showed that IL-2 increased the abundance of mRNAs encoding the NF-kappaB components c-Rel and KBF1 in these cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
28	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
29	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
30	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	mRNAs	mRNA	SCONJ	IN	_	_	_	_	_
40	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
45	components	component	NOUN	NNS	Number=Plur	_	_	_	_
46	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
47	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 355
# text = IL-2 binding analysis demonstrated that IL-2 markedly increased the number of low affinity IL-2Rs on the leukemia cells, without an effect on the number of high-affinity IL-2Rs.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	markedly	markedly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	Rs	R	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	without	without	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	number	number	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
37	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2Rs	2R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 356
# text = These results show that IL-2 is capable of inducing the nuclear expression of NF-kappaB in primary CD8+ T-PLL cells, and that this effect is mediated, at least in part, at a pretranslational level.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
21	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	PLL	pLl	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	at	at	ADV	RB	_	_	_	_	_
36	least	least	ADV	RBS	Degree=Sup	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	at	at	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	pretranslational	pretranslational	ADJ	JJ	Degree=Pos	_	_	_	_
43	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 357
# text = Document 003002129 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002129	003002129	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 358
# text = Impaired fetal thymocyte development after efficient adenovirus-mediated inhibition of NF-kappa B activation.
1	Impaired	Impaire	ADJ	JJ	Degree=Pos	_	_	_	_
2	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
3	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-mediated	-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 359
# text = We introduce a new experimental system combining adenovirus-mediated gene transfer and fetal thymic organ culture (FTOC).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	introduce	introduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
6	system	system	NOUN	NN	Number=Sing	_	_	_	_
7	combining	combi	VERB	VBG	VerbForm=Ger	_	_	_	_
8	adenovirus	adenovirus	ADP	IN	_	_	_	_	SpaceAfter=No
9	-mediated	-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
15	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
16	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	FTOC	FTOC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 360
# text = This system allowed us to efficiently express in developing thymocytes a mutant form of the NF-kappa B inhibitor
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	system	system	NOUN	NN	Number=Sing	_	_	_	_
3	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	efficiently	efficiently	ADV	RB	_	_	_	_	_
7	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
13	form	form	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 361
# text = I kappa B alpha (mut-I kappa B) and to study the maturation defects occurring when NF-kappa B activation is inhibited during fetal development.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
17	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
18	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	NF	NF	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 362
# text = Fetal thymocytes infected with adenovirus containing mut-I kappa B were found to develop normally until the CD44-CD25+, CD4-CD8- double-negative stage, while production of more mature double-positive and single-positive populations was strongly decreased.
1	Fetal	Fetal	ADJ	JJ	Degree=Pos	_	_	_	_
2	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
6	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
7	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
16	normally	normally	ADV	RB	_	_	_	_	_
17	until	until	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	CD44-CD25+	Cd44-cd25+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	CD4-CD8	Cd4-cd8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	_
23	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
26	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	while	while	SCONJ	IN	_	_	_	_	_
29	production	production	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
32	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
33	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
40	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	strongly	strongly	ADV	RB	_	_	_	_	_
43	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 363
# text = Proliferation, as measured by the percentage of cells in cycle appeared normal, as did rearrangement and expression of the TCR beta-chain.
1	Proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
12	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 364
# text = However, apoptosis was much higher in FTOC infected with adenovirus containing mut-I kappa B than in FTOC infected with a control virus.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	much	much	ADV	RB	_	_	_	_	_
6	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	FTOC	FTOC	PROPN	NNP	Number=Sing	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
12	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
13	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	FTOC	FTOC	PROPN	NNP	Number=Sing	_	_	_	_
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	control	control	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 365
# text = Taken together, these results suggest that NF-kappa B plays a crucial role in ensuring the differentiation and survival of thymocytes in the early stages of their development.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	ensuring	ensure	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
27	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 366
# text = Document 003002140 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002140	003002140	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 367
# text = Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 368
# text = The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter contains a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor, which consists of alpha and beta subunits.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
5	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	polyomavirus	polyomavirus	NOUN	NN	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
25	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	PEBP2	PEBP2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
40	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 369
# text = There are at least two genes, alpha
1	There	there	PRON	EX	_	_	_	_	_
2	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	at	at	ADV	RB	_	_	_	_	_
4	least	least	ADV	RBS	Degree=Sup	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 370
# text = A and alpha B, encoding the alpha subunit.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 371
# text = alpha
1	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 372
# text = B is the mouse homologue of human AML1 gene detected at the breakpoints of t(8;21) and t(3;21) myeloid leukemias.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
5	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	AML1	AML1	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	breakpoints	breakpoint	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	8;21	8;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	3;21	3;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	myeloid	myeloid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 373
# text = We examined alpha A1 (an alpha
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	alpha	alpha	ADP	IN	_	_	_	_	_
4	A1	A1	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 374
# text = A-gene product) and alpha B1 and alpha B2 (two alpha B-encoded isomers) for their effects on the GM-CSF promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
8	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	alpha	alpha	ADP	IN	_	_	_	_	_
11	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	isomers	isomer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 375
# text = PEBP2 alpha A1, alpha B1, and alpha B2 proteins bound the PEBP2 site within the mouse GM-CSF promoter.
1	PEBP2	PEBP2	NOUN	NN	Number=Sing	_	_	_	_
2	alpha	alpha	ADP	IN	_	_	_	_	_
3	A1	A1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	alpha	alpha	ADP	IN	_	_	_	_	_
6	B1	B1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	alpha	alpha	ADP	IN	_	_	_	_	_
10	B2	B2	NOUN	NN	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	PEBP2	Pebp2	NUM	CD	NumType=Card	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
19	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 376
# text = PEBP2 alpha A1 and alpha B1 enhanced the expression of the GM-CSF promoter-driven reporter plasmid in unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells.
1	PEBP2	PEBP2	NOUN	NN	Number=Sing	_	_	_	_
2	alpha	alpha	ADP	IN	_	_	_	_	_
3	A1	A1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
6	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
7	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
28	13-acetate/phytohemagglutinin-stimulated	13-acetate/phytohemagglutinin-stimulated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 377
# text = In contrast, the promoter activity was suppressed by alpha B2. Coexpression of alpha B1 and alpha B2 showed that the promoter activity could be determined by the alpha B1/alpha B2 ratio.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	B2	B2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_
13	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	B1	b1	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	B2	B2	NOUN	NN	Number=Sing	_	_	_	_
20	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	B1	B1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	B2	B2	NUM	CD	NumType=Card	_	_	_	_
35	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 378
# text = Jurkat cell extract contained PEBP2 site-binding protein(s) that cross-reacted with antimouse alpha A1 antibodies.
1	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
4	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	s	s	X	AFX	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	cross-reacted	cross-reacted	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	antimouse	antimouse	NOUN	NN	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	A1	A1	NUM	CD	NumType=Card	_	_	_	_
19	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 379
# text = Northern blot analysis indicated the expression of human PEBP2 alpha
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 380
# text = A, alpha B (AML1), and beta genes in Jurkat cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	AML1	Aml1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 381
# text = Although further studies are required to determine the precise role of PEBP2 in the GM-CSF promoter activity, the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	PEBP2	Pebp2	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
23	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
24	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
30	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
34	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	SCONJ	IN	_	_	_	_	_
36	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 382
# text = Document 003002141 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002141	003002141	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 383
# text = Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
6	lipase	lipase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	differentiating	differentiating	NOUN	NN	Number=Sing	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 384
# text = Human lysosomal acid lipase (LAL) is a hydrolase required for the cleavage of cholesteryl esters and triglycerides derived from plasma lipoproteins.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
3	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
4	lipase	lipase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LAL	LAL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	hydrolase	hydrolase	NOUN	NN	Number=Sing	_	_	_	_
11	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cholesteryl	cholesteryl	ADJ	JJ	Degree=Pos	_	_	_	_
17	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	triglycerides	triglyceride	NOUN	NNS	Number=Plur	_	_	_	_
20	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
23	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 385
# text = It is shown here that during monocyte to macrophage differentiation, the expression of LAL-mRNA is induced.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	LAL	LAL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 386
# text = This induction is dependent on protein kinase C activity and protein synthesis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C	C	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 387
# text = The cell type-specific increase in LAL expression is further investigated in the THP-1 cell line with respect to transcriptional regulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	LAL	Lal	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	further	further	ADV	RB	_	_	_	_	_
12	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 388
# text = The human monocytic leukemia cell line THP-1 differentiates into macrophage-like cells when treated with phorbol esters.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	differentiates	differentiate	NOUN	NNS	Number=Plur	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 389
# text = In order to determine the cis-acting elements necessary for both basal and phorbol 12-myristate-13 acetate (PMA)-enhanced promoter activity, we performed deletion analysis and reporter gene assays.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
15	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-13	-13	NUM	CD	NumType=Card	_	_	_	_
19	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
29	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
31	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 390
# text = A PMA responsive element has been identified between -182 bp and -107 bp upstream of the major transcription start site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
3	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	182	182	NUM	CD	NumType=Card	_	_	_	_
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	107	107	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	start	start	NOUN	NN	Number=Sing	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 391
# text = Gel mobility shift assays demonstrated that binding of Sp1 and AP-2 to the LAL promoter is increased by PMA in THP-1 cells.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	LAL	Lal	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	THP	THP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 392
# text = Co-transfections with expression plasmids for Sp1 and AP-2 further emphasized the important role of these transcription factors in both basal and PMA-enhanced LAL expression.
1	Co	co	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-transfections	-transfection	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	further	further	ADV	RB	_	_	_	_	_
13	emphasized	emphasize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	LAL	Lal	ADJ	JJ	Degree=Pos	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 393
# text = Our data suggest that differentiation dependent increase of lysosomal acid lipase (LAL) expression in THP-1 cells is mediated by a concerted action of Sp1 and AP-2.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
11	lipase	lipase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LAL	LAL	INTJ	UH	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	concerted	concert	ADJ	JJ	Degree=Pos	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 394
# text = Document 003002142 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002142	003002142	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 395
# text = NF-kappaB regulates Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	Fas/APO-1/CD95-	Fas/APO-1/CD95-	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 396
# text = The maintenance of lymphocyte homeostasis by apoptosis is a critical regulatory mechanism in the normal immune system.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 397
# text = The transcription factor NF-kappaB has been shown to play a role in protecting cells against death mediated by TNF
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	protecting	protect	VERB	VBG	VerbForm=Ger	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	against	against	ADP	IN	_	_	_	_	_
18	death	death	NOUN	NN	Number=Sing	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 398
# text = We show here that NF-kappaB also has a role in regulating Fas/APO-1/CD95-mediated death, a major pathway of peripheral T cell death.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	Fas/APO-1/CD95-mediated	Fas/APO-1/CD95-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
15	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 399
# text = Transfection of Jurkat cells with the NF-kappaB subunits p50 and p65 confers resistance against Fas-mediated apoptosis.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	p50	p50	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
15	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
16	against	against	ADP	IN	_	_	_	_	_
17	Fas-	Fas-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 400
# text = Reciprocally, inhibition of NF-kappaB activation by a soluble peptide inhibitor or a dominant form of the NF-kappaB inhibitor, IkappaB, makes the cells more susceptible to Fas-mediated apoptosis.
1	Reciprocally	Reciprocally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	makes	make	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	more	more	ADV	RBR	_	_	_	_	_
31	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 401
# text = Furthermore, inhibition of NF-kappaB activation by a soluble peptide inhibitor rendered a T cell hybridoma more susceptible to TCR-mediated apoptosis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	hybridoma	hybridoma	NOUN	NN	Number=Sing	_	_	_	_
19	more	more	ADV	RBR	_	_	_	_	_
20	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 402
# text = Correspondingly, transfection of p50 and p65 provided considerable protection from TCR-mediated apoptosis.
1	Correspondingly	Correspondingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p50	p50	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p65	p65	NUM	CD	NumType=Card	_	_	_	_
8	provided	provide	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
10	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 403
# text = These observations were corroborated by studies on Fas-mediated death in primary T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	corroborated	corroborate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	death	death	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 404
# text = Concanavalin
1	Concanavalin	Concanavalin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 405
# text = A-activated cycling T cell blasts from mice that are transgenic for the dominant IkappaB molecule have increased sensitivity to Fas-mediated apoptosis, associated with a down-regulation of NF-kappaB complexes in the nucleus.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cycling	cycling	NOUN	NN	Number=Sing	_	_	_	_
5	T	t	NUM	CD	NumType=Card	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
16	IkappaB	IkappaB	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
36	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 406
# text = In addition, blocking TNF, itself a positive regulator of NF-kappaB, with neutralizing antibodies renders the cells more susceptible to anti-Fas-mediated apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	with	with	SCONJ	IN	_	_	_	_	_
17	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_
18	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
19	renders	render	NOUN	NNS	Number=Plur	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	more	more	ADV	RBR	_	_	_	_	_
23	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
26	-Fas-	-Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 407
# text = In summary, our results provide compelling evidence that NF-kappaB protects against Fas-mediated death and is likely to be an important regulator of T cell homeostasis and tolerance.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	compelling	compelling	ADJ	JJ	Degree=Pos	_	_	_	_
8	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	protects	protect	NOUN	NNS	Number=Plur	_	_	_	_
14	against	against	ADP	IN	_	_	_	_	_
15	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	death	death	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 408
# text = Document 003002145 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002145	003002145	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 409
# text = An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Y	y	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
37	family	family	NOUN	NN	Number=Sing	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 410
# text = Expression of the human interleukin-2 (IL-2) receptor alpha chain gene is potently upregulated by its own ligand, IL-2.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	potently	potently	ADV	RB	_	_	_	_	_
19	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 411
# text = In this study, we characterize an essential upstream IL-2 response element that contains both consensus and non-consensus GAS motifs, two putative Ets binding sites (EBS), one of which overlaps the consensus GAS motif, and a GATA motif, which overlaps the non-consensus GAS motif.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	characterize	characterize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	non-consensus	non-consensus	ADJ	JJ	Degree=Pos	_	_	_	_
21	GAS	gas	NOUN	NNS	Number=Plur	_	_	_	_
22	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
26	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
39	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
40	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
45	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	which	which	PRON	WDT	PronType=Rel	_	_	_	_
48	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	non-consensus	non-consensus	ADJ	JJ	Degree=Pos	_	_	_	_
51	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
52	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 412
# text = We demonstrate that although the individual components of this element do not respond to IL-2, together they form a composite element capable of conferring IL-2 responsiveness to a heterologous promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	although	although	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	together	together	SCONJ	IN	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	form	form	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	composite	composite	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
26	of	of	SCONJ	IN	_	_	_	_	_
27	conferring	conferr	VERB	VBG	VerbForm=Ger	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 413
# text = Multiple factors including Stat5, Elf-1, HMG-I(Y) and GATA family proteins bind to the IL-2 response element and mutation of any one of these binding sites diminishes the activity of this element.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
4	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	any	any	DET	DT	_	_	_	_	_
31	one	one	NUM	CD	NumType=Card	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	diminishes	diminish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
41	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 414
# text = An unidentified Ets family protein binds to the EBS overlapping the consensus GAS motif and appears to negatively regulate the human IL-2R alpha promoter.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
3	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	EBS	Eb	PROPN	NNP	Number=Sing	_	_	_	_
10	overlapping	overlapp	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
14	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	negatively	negatively	ADV	RB	_	_	_	_	_
19	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	R	r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	ADP	IN	_	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 415
# text = Thus, IL-2-induced IL-2R alpha promoter activity requires a complex upstream element, which appears to contain binding sites for both positive and negative regulatory factors.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
17	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 416
# text = Document 003002146 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002146	003002146	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 417
# text = Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.
1	Genomic	Genomic	ADJ	JJ	Degree=Pos	_	_	_	_
2	organization	organization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	eotaxin	eotaxin	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 418
# text = Eotaxin is an eosinophil specific beta-chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
1	Eotaxin	Eotaxin	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	eosinophil	eosinophil	ADJ	JJ	Degree=Pos	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
9	assumed	assume	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
20	dermatitis	dermatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
23	rhinitis	rhinitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	parasitic	parasitic	ADJ	JJ	Degree=Pos	_	_	_	_
28	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 419
# text = Its expression is stimulus- and cell-specific.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 420
# text = We here describe the genomic organisation (3 exons of 132, 112 and 542 bp and 2 introns of 1211 and 378 bp) and sequence including 3 kb of DNA from the immediate 5' upstream region of the human eotaxin gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	here	here	ADV	RB	PronType=Dem	_	_	_	_
3	describe	describe	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	organisation	organisation	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	132	132	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	112	112	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	542	542	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	introns	intron	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	1211	1211	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	378	378	NUM	CD	NumType=Card	_	_	_	_
24	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	3	3	NUM	CD	NumType=Card	_	_	_	_
30	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
36	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	'	'	PUNCT	``	_	_	_	_	_
38	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	eotaxin	eotaxin	NOUN	NN	Number=Sing	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 421
# text = Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.
1	Among	among	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	potentially	potentially	ADV	RB	_	_	_	_	_
7	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	eotaxin	eotaxin	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	or	or	CCONJ	CC	_	_	_	_	_
14	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
24	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	like	like	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-B	-b	NOUN	NN	Number=Sing	_	_	_	_
44	like	like	ADP	IN	_	_	_	_	_
45	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
46	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	_
52	as	as	ADV	RB	_	_	_	_	_
53	well	well	ADV	RB	Degree=Pos	_	_	_	_
54	as	as	ADP	IN	_	_	_	_	_
55	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
56	response	response	NOUN	NN	Number=Sing	_	_	_	_
57	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 422
# text = Document 003002148 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002148	003002148	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 423
# text = Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras.
1	Calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-early	-early	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	negatively	negatively	ADV	RB	_	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	p21Ha	p21Ha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 424
# text = The induction of immediate-early (IE) response genes, such as egr-1, c-fos, and c-jun, occurs rapidly after the activation of T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IE	ie	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	egr	egr	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	occurs	occurs	NOUN	NNS	Number=Plur	_	_	_	_
26	rapidly	rapidly	ADV	RB	_	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 425
# text = The process of activation involves calcium mobilization, activation of protein kinase C (PKC), and phosphorylation of tyrosine kinases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	process	process	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
6	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
7	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 426
# text = p21(ras), a guanine nucleotide binding factor, mediates T-cell signal transduction through PKC-dependent and PKC-independent pathways.
1	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
8	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
13	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	PKC	Pkc	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 427
# text = The involvement of p21(ras) in the regulation of calcium-dependent signals has been suggested through analysis of its role in the activation of NF-AT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p21	p21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 428
# text = We have investigated the inductions of the IE genes in response to calcium signals in Jurkat cells (in the presence of activated p21(ras)) and their correlated consequences.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inductions	induction	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	calcium	calcium	VERB	VB	VerbForm=Inf	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
32	consequences	consequences	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 429
# text = The expression of activated p21(ras) negatively regulated the induction of IE genes by calcium ionophore.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	negatively	negatively	ADV	RB	_	_	_	_	_
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
18	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 430
# text = This inhibition of calcium-activated IE gene induction was reversed by treatment with cyclosporin A, suggesting the involvement of calcineurin in this regulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	calcium-	calcium-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 431
# text = A later result of inhibition of this activation pathway by p21(ras) was down-regulation of the activity of the transcription factor AP-1 and subsequent coordinate reductions in IL-2 gene expression and protein production.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	later	later	ADJ	JJ	Degree=Pos	_	_	_	_
3	result	result	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	ras	ras	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
31	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
32	reductions	reduction	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 432
# text = These results suggest that p2l(ras) is an essential mediator in generating not only positive but also negative modulatory mechanisms controlling the competence of T cells in response to inductive stimulations.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	p2l(	p2l(	SYM	NFP	_	_	_	_	SpaceAfter=No
6	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	generating	generate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	modulatory	modulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
22	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	competence	competence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	inductive	inductive	ADJ	JJ	Degree=Pos	_	_	_	_
32	stimulations	stimulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 433
# text = Document 003002155 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002155	003002155	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 434
# text = NF-X2 that binds to the DRA X2-box is activator protein 1.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
9	X2	X2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 435
# text = Expression cloning of c-Jun.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 436
# text = Human class II MHC
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 437
# text = Ag are a family of cell surface glycoproteins.
1	Ag	ag	NOUN	NN	Number=Sing	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
8	glycoproteins	glycoprotein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 438
# text = Their constitutive expression is limited to B lymphocytes and thymic epithelial cells.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
11	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 439
# text = In many other cells their expression can be induced by IFN-gamma.
1	In	in	ADP	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 440
# text = Conserved upstream promoter sequences regulate this tissue-specific expression of class II genes.
1	Conserved	Conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 441
# text = In the DRA promoter, one of these cis-acting regulatory motifs is the X2-box to which nuclear factor X2 (NF-X2) binds.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	X2	x2	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	binds	bind	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 442
# text = Here, we present the isolation and characterization of the full-length cDNA clone encoding NF-X2.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	present	present	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	length	length	NOUN	NN	Number=Sing	_	_	_	_
14	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
15	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
16	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 443
# text = This cDNA clone was isolated by expression cDNA cloning, and encodes the human c-Jun protein, which together with c-Fos forms the heterodimeric activator protein-1 transcription complex.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
9	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	together	together	ADV	RB	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
25	forms	form	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
28	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 444
# text = Whereas c-Fos/c-Jun heterodimers do not exist in B cells, they form and bind to the X2-box in class II nonexpressing cells.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-Jun	-Jun	PROPN	NNP	Number=Sing	_	_	_	_
4	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
5	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
13	form	form	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	X2	X2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	box	box	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	_
24	nonexpressing	nonexpresse	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 445
# text = Thus, c-Fos/c-Jun heterodimers might contribute to the repression of DRA gene expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
6	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
7	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
8	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	DRA	DRA	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 446
# text = Document 003002158 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002158	003002158	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 447
# text = The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 448
# text = The HTLV-I transcriptional activator tax was used to gain insight into the mechanism of lymphotoxin (LT; TNF-beta) gene induction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
12	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 449
# text = Tax-expressing cell lines produce LT biologic activity.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
8	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 450
# text = An LT promoter (LT-293)
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	LT	Lt	ADJ	JJS	Degree=Sup	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	LT	LT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	293	293	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 451
# text = CAT construct that contained an NF-kappa B site was active in the LT-producing C81-66-45 cell line, which contains defective HTLV-I but expresses tax.
1	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
2	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	LT-	Lt-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	C81-66	C81-66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	45	45	NUM	CD	NumType=Card	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
26	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 452
# text = The observation that a mutated LT-kappa B construct (M1-CAT) was inactive in C81-66-45, confirmed the importance of NF-kappa B in LT gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	M1	m1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	C81-66	C81-66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-45	-45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	LT	LT	PROPN	NNP	Number=Sing	_	_	_	_
32	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 453
# text = Tax was transfected into HTLV-I-negative human T-cell lines.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	into	into	ADP	IN	_	_	_	_	_
5	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 454
# text = Jurkat
1	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 455
# text = T cells stably expressing tax contained elevated levels of NF-kappa B that directly bound to the LT-kappa B site.
1	T	t	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
5	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	directly	directly	ADV	RB	_	_	_	_	_
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 456
# text = Tax co-transfected with reporter constructs into Jurkat cells maximally activated HTLV-I-LTR-CAT and kappa B-fos-CAT and also activated LT-293 to a lesser extent.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	maximally	maximally	ADV	RB	_	_	_	_	_
10	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	fos	fos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	293	293	NUM	CD	NumType=Card	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
33	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 457
# text = In JM T cells, tax induced LT-293 activity by two- to four-fold, though there was no induction of M1-CAT.
1	In	in	ADP	IN	_	_	_	_	_
2	JM	JM	PROPN	NNP	Number=Sing	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	293	293	NUM	CD	NumType=Card	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	four	four	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	though	though	SCONJ	IN	_	_	_	_	_
21	there	there	PRON	EX	_	_	_	_	_
22	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	no	no	DET	DT	_	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	M1	M1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 458
# text = The increase in LT-293 CAT activity mirrored the increase in LT biologic activity seen under these conditions.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	293	293	NUM	CD	NumType=Card	_	_	_	_
7	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	mirrored	mirror	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	LT	LT	PROPN	NNP	Number=Sing	_	_	_	_
14	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	under	under	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 459
# text = These studies, the first to demonstrate induction of LT promoter activity over basal levels, indicate that HTLV-I tax causes low-level activation of both endogenous LT and the LT promoter, at least in part through activation of NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	over	over	ADP	IN	_	_	_	_	_
14	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
23	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
31	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	at	at	ADV	RB	_	_	_	_	_
38	least	least	ADV	RBS	Degree=Sup	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	part	part	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
47	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 460
# text = Document 003002162 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002162	003002162	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 461
# text = Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
6	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
7	differentially	differentially	ADV	RB	_	_	_	_	_
8	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	release	release	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
19	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 462
# text = Triggering of HLA class II antigens by the anti-HLA-DR monoclonal antibody (mAb) L243 significantly (P < 0.05) and differentially enhanced the release of tumor necrosis factor alpha (TNF-alpha) by the non-Hodgkin's lymphoma cells Ri-I, Ci-I, and Sc-I, which are at a distinct stage of B-cell differentiation, and by the more mature Burkitt lymphoma cell Raji; in contrast, it did not induce TNF-alpha release by the pre-B leukemia cells Nalm-6 and BV173.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	anti-HLA	anti-hla	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	DR	Dr	ADJ	JJ	Degree=Pos	_	_	_	_
12	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
13	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	L243	L243	NOUN	NN	Number=Sing	_	_	_	_
18	significantly	significantly	ADV	RB	_	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	P	p	NOUN	NN	Number=Sing	_	_	_	_
21	<	<	PUNCT	-LRB-	_	_	_	_	_
22	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	differentially	differentially	ADV	RB	_	_	_	_	_
26	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	release	release	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
31	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	non-Hodgkin	non-hodgkin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	's	's	PART	POS	_	_	_	_	_
43	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	Ri	ri	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	Ci	Ci	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	Sc	Sc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
56	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	which	which	PRON	WDT	PronType=Rel	_	_	_	_
59	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
60	at	at	ADP	IN	_	_	_	_	_
61	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
63	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
68	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	by	by	ADP	IN	_	_	_	_	_
72	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
73	more	more	ADV	RBR	_	_	_	_	_
74	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
75	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	_
76	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
77	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
78	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	;	;	PUNCT	,	_	_	_	_	_
80	in	in	ADP	IN	_	_	_	_	_
81	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
84	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
85	not	not	PART	RB	_	_	_	_	_
86	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
87	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
89	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
90	release	release	NOUN	NN	Number=Sing	_	_	_	_
91	by	by	ADP	IN	_	_	_	_	_
92	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
93	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
94	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
95	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
96	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
97	Nalm	Nalm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
98	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
99	6	6	NUM	CD	NumType=Card	_	_	_	_
100	and	and	CCONJ	CC	_	_	_	_	_
101	BV	BV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
102	173	173	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
103	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 463
# text = TNF-alpha release peaked at 24 h and decreased thereafter, and it was dose dependent and preceded by an increase of TNF-alpha mRNA detectable after 3 h of stimulation with mAb L243.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	release	release	NOUN	NN	Number=Sing	_	_	_	_
5	peaked	peake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	24	24	NUM	CD	NumType=Card	_	_	_	_
8	h	h	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	thereafter	thereafter	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	dose	dose	VERB	VB	VerbForm=Inf	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
27	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
28	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	h	h	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
36	L243	L243	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 464
# text = Secreted TNF-alpha mediated the enhancement of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1) binding activity; in fact, the triggering of HLA-DR antigens in the presence of antihuman TNF-alpha-neutralizing antibodies did not upregulate NF-kappa B and AP-1.
1	Secreted	Secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
41	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	antihuman	antihuman	ADJ	JJ	Degree=Pos	_	_	_	_
47	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
52	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
53	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
54	not	not	PART	RB	_	_	_	_	_
55	upregulate	upregulate	VERB	VB	VerbForm=Inf	_	_	_	_
56	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
59	B	b	NOUN	NN	Number=Sing	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 465
# text = In contrast, released TNF-alpha was not responsible for the homotypic aggregation of Ri-I, Ci-I, Sc-I, and Raji cells induced by mAb L243, and it did not affect the proliferation of B cells investigated.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	homotypic	homotypic	ADJ	JJ	Degree=Pos	_	_	_	_
14	aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Ri	ri	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	Ci	Ci	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Sc	Sc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
34	L243	L243	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
38	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	not	not	PART	RB	_	_	_	_	_
40	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 466
# text = Altogether, our data demonstrate that: (a) the ability of B cells to release TNF-alpha after triggering of HLA-DR antigens depends on their stage of differentiation; (b) levels of released TNF-alpha seem to correlate with the stage of B-cell maturation but do not correlate with the amounts of cell surface HLA-DR antigens; (c) secreted TNF-alpha regulates the levels of expression of NF-kappa B and AP-1 by an autocrine loop; and (d) intracellular signals mediating TNF-alpha release by B cells are distinct from those regulating homotypic aggregation and proliferation.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	a	a	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	SCONJ	IN	_	_	_	_	_
22	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
27	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
28	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	;	;	PUNCT	,	_	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
44	seem	seem	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
47	with	with	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
54	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
55	but	but	CCONJ	CC	_	_	_	_	_
56	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
57	not	not	PART	RB	_	_	_	_	_
58	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
59	with	with	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
64	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
65	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	DR	dr	NOUN	NN	Number=Sing	_	_	_	_
68	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
69	;	;	PUNCT	,	_	_	_	_	_
70	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
71	c	c	X	LS	_	_	_	_	SpaceAfter=No
72	)	)	PUNCT	-RRB-	_	_	_	_	_
73	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
74	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
77	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
78	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
79	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
80	of	of	ADP	IN	_	_	_	_	_
81	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
82	of	of	ADP	IN	_	_	_	_	_
83	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
84	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
85	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
86	B	b	NOUN	NN	Number=Sing	_	_	_	_
87	and	and	CCONJ	CC	_	_	_	_	_
88	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
89	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
90	1	1	NUM	CD	NumType=Card	_	_	_	_
91	by	by	ADP	IN	_	_	_	_	_
92	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
93	autocrine	autocrine	ADJ	JJ	Degree=Pos	_	_	_	_
94	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
95	;	;	PUNCT	,	_	_	_	_	_
96	and	and	CCONJ	CC	_	_	_	_	_
97	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
98	d	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
99	)	)	PUNCT	-RRB-	_	_	_	_	_
100	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
101	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
102	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
103	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
104	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
105	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
106	release	release	NOUN	NN	Number=Sing	_	_	_	_
107	by	by	ADP	IN	_	_	_	_	_
108	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
109	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
110	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
111	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
112	from	from	ADP	IN	_	_	_	_	_
113	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
114	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
115	homotypic	homotypic	ADJ	JJ	Degree=Pos	_	_	_	_
116	aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	_
117	and	and	CCONJ	CC	_	_	_	_	_
118	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
119	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 467
# text = Document 003002164 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002164	003002164	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 468
# text = The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	_
7	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	engages	engage	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	receptor-	receptor-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	TRADD	Tradd	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	receptor-	receptor-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	RIP	rip	INTJ	UH	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
31	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
34	RIP	RIP	PROPN	NNP	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 469
# text = A site in the Epstein-Barr virus (EBV) transforming protein LMP1 that constitutively associates with the tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein TRADD to mediate NF-kappaB and c-Jun N-terminal kinase activation is critical for long-term lymphoblastoid cell proliferation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	constitutively	constitutively	ADV	RB	_	_	_	_	_
17	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNFR1	TNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	death	death	NOUN	NN	Number=Sing	_	_	_	_
31	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	TRADD	TRADD	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
43	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
44	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
45	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
47	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
49	for	for	ADP	IN	_	_	_	_	_
50	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	term	term	NOUN	NN	Number=Sing	_	_	_	_
53	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
54	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
55	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 470
# text = We now find that LMP1 signaling through TRADD differs from TNFR1 signaling through TRADD.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
6	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
9	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	TNFR1	TNFR1	PROPN	NNP	Number=Sing	_	_	_	_
12	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	TRADD	TRADD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 471
# text = LMP1 needs only 11 amino acids to activate NF-kappaB or synergize with TRADD in NF-kappaB activation, while TNFR1 requires approximately 70 residues.
1	LMP1	LMP1	NOUN	NN	Number=Sing	_	_	_	_
2	needs	need	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	11	11	NUM	CD	NumType=Card	_	_	_	_
5	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
6	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	synergize	synergize	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	while	while	SCONJ	IN	_	_	_	_	_
23	TNFR1	TNFR1	PROPN	NNP	Number=Sing	_	_	_	_
24	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	approximately	approximately	ADV	RB	_	_	_	_	_
26	70	70	NUM	CD	NumType=Card	_	_	_	_
27	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 472
# text = Further, LMP1 does not require TRADD residues 294 to 312 for NF-kappaB activation, while TNFR1 requires TRADD residues 296 to 302.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
7	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
8	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
9	294	294	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	312	312	NUM	CD	NumType=Card	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	TNFR1	TNFR1	PROPN	NNP	Number=Sing	_	_	_	_
20	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	TRADD	Tradd	PROPN	NNP	Number=Sing	_	_	_	_
22	residues	residue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	296	296	NUM	CD	NumType=Card	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	302	302	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 473
# text = LMP1 is partially blocked for NF-kappaB activation by a TRADD mutant consisting of residues 122 to 293.
1	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	partially	partially	ADV	RB	_	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
13	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
14	consisting	consisting	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
17	122	122	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	293	293	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 474
# text = Unlike TNFR1, LMP1 can interact directly with receptor-interacting protein (RIP) and stably associates with RIP in EBV-transformed lymphoblastoid cell lines.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	TNFR1	TNFR1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
7	directly	directly	ADV	RB	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	interacting	interacting	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	RIP	rip	INTJ	UH	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	stably	stably	ADV	RB	_	_	_	_	_
18	associates	associate	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	RIP	Rip	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	EBV-	EBV-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 475
# text = Surprisingly, LMP1 does not require RIP for NF-kappaB activation.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
7	RIP	Rip	PROPN	NNP	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 476
# text = Despite constitutive association with TRADD or RIP, LMP1 does not induce apoptosis in EBV-negative Burkitt lymphoma or human embryonic kidney 293 cells.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	association	association	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	TRADD	tRADd	PROPN	NNP	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	RIP	rip	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	Burkitt	Burkitt	NOUN	NN	Number=Sing	_	_	_	_
19	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
23	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
24	293	293	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 477
# text = These results add a different perspective to the molecular interactions through which LMP1, TRADD, and RIP participate in B-lymphocyte activation and growth.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	add	add	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	perspective	perspective	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
10	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	which	which	DET	WDT	PronType=Int	_	_	_	_
13	LMP1	LMP1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	TRADD	TRADD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	RIP	rip	INTJ	UH	_	_	_	_	_
19	participate	participate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 478
# text = Document 003002175 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002175	003002175	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 479
# text = Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
17	without	without	ADP	IN	_	_	_	_	_
18	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 480
# text = NF-kappa B is involved in the transcriptional control of various genes that act as extrinsic and intrinsic survival factors for T cells.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	extrinsic	extrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
20	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 481
# text = Our findings show that suppression of NF-kappa B activity with cell-permeable SN50 peptide, which masks the nuclear localization sequence of NF-kappa B1 dimers and prevents their nuclear localization, induces apoptosis in resting normal human PBL.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	permeable	permeable	ADJ	JJ	Degree=Pos	_	_	_	_
16	SN50	SN50	NOUN	NN	Number=Sing	_	_	_	_
17	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	masks	mask	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
30	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
33	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	localization	localization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
38	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	in	in	SCONJ	IN	_	_	_	_	_
40	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
41	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 482
# text = Inhibition of NF-kappa B resulted in the externalization of phosphatidylserine, induction of DNA breaks, and morphological changes consistent with apoptosis.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	externalization	externalization	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	phosphatidylserine	phosphatidylserine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	breaks	break	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
21	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
22	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 483
# text = DNA fragmentation was efficiently blocked by the caspase inhibitor Z-VAD-fmk and partially blocked by Ac-DEVD-fmk, suggesting that SN50-mediated apoptosis is caspase-dependent.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	efficiently	efficiently	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	Z	z	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	VAD	Vad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	partially	partially	ADV	RB	_	_	_	_	_
17	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	Ac-	Ac-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	DEVD	Devd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	SN50	SN50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 484
# text = Interestingly, apoptosis induced by NF-kappa B suppression, in contrast to that induced by TPEN (N,N,N',N'-tetrakis [2-pyridylmethyl]ethylenediamine) or soluble Fas ligand (CD95), was observed in the absence of active death effector proteases caspase-1-like (IL-1 converting enzyme), caspase-3-like (CPP32/Yama/apopain), and caspase-6-like and without cleavage of caspase-3 substrates poly(ADP-ribose) polymerase and DNA fragmentation factor-45.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TPEN	TPEN	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	N,N,N'	N,N,N'	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
22	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	'	's	PART	POS	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	tetrakis	tetrakis	NOUN	NN	Number=Sing	_	_	_	_
26	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	pyridylmethyl	pyridylmethyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	ethylenediamine	ethylenediamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
35	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
36	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
48	death	death	NOUN	NN	Number=Sing	_	_	_	_
49	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
50	proteases	protease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
51	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	like	like	INTJ	UH	_	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1	1	NUM	CD	NumType=Card	_	_	_	_
60	converting	converting	NOUN	NN	Number=Sing	_	_	_	_
61	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	like	like	INTJ	UH	_	_	_	_	_
69	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
70	CPP32/	CPP32/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
71	Yama/	Yama/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
72	apopain	apopain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
74	,	,	PUNCT	,	_	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	-like	-like	ADJ	JJ	Degree=Pos	_	_	_	_
80	and	and	CCONJ	CC	_	_	_	_	_
81	without	without	ADP	IN	_	_	_	_	_
82	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
85	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
86	3	3	NUM	CD	NumType=Card	_	_	_	_
87	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
88	poly	poly	ADV	RB	_	_	_	_	SpaceAfter=No
89	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
90	ADP	Adp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
91	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
92	ribose	ribose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
93	)	)	PUNCT	-RRB-	_	_	_	_	_
94	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
95	and	and	CCONJ	CC	_	_	_	_	_
96	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
97	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
98	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
99	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
100	45	45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
101	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 485
# text = These findings suggest either low level of activation is required or that different caspases are involved.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	that	that	PRON	WDT	PronType=Dem	_	_	_	_
13	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
14	caspases	caspase	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 486
# text = Preactivation of T cells resulting in NF-kappa B nuclear translocation protected cells from SN50-induced apoptosis.
1	Preactivation	Preactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
13	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	SN50	SN50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 487
# text = Our findings demonstrate an essential role of NF-kappa B in survival of naive PBL.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
16	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 488
# text = Document 003002177 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002177	003002177	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 489
# text = Dysregulation of monocytic nuclear factor-kappa B by oxidized low-density lipoprotein.
1	Dysregulation	Dysregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	oxidized	oxidize	ADJ	JJ	Degree=Pos	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	density	density	NOUN	NN	Number=Sing	_	_	_	_
14	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 490
# text = Nuclear factor-kappa B (NF-kappa B)/Rel transcription factors may be involved in atherosclerosis, as is suggested by the presence of activated NF-kappa B in human atherosclerotic lesions.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
37	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 491
# text = The aim of the present study was to investigate the effects of oxidized LDL (oxLDL) on the NF-kappa B system in human THP-1 monocytic cells as well as adherent monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	LDL	LDL	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	oxLDL	oxLDL	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 492
# text = Our results demonstrate that short-term incubation of these cells with oxLDL activated p50/p65 containing NF-kappa B dimers and induced the expression of the target gene IL-8.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	term	term	NOUN	NN	Number=Sing	_	_	_	_
8	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	target	target	NOUN	NN	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 493
# text = This activation of NF-kappa B was inhibited by the antioxidant and H2O2 scavenger pyrrolidine dithiocarbamate and the proteasome inhibitor PSI.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
15	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
16	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
17	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	PSI	pSi	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 494
# text = The oxLDL-induced NF-kappa B activation was accompanied by an initial depletion of I kappa B-alpha followed by a slight transient increase in the level of this inhibitor protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	oxLDL	oxldl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
15	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	ADV	RB	_	_	_	_	_
21	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
25	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
26	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 495
# text = In contrast, long-term treatment with oxLDL prevented the lipopolysaccharide-induced depletion of I kappa B-alpha, accompanied by an inhibition of both NF-kappa B activation and the expression of tumor necrosis factor-alpha and interleukin-1 beta genes.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	term	term	NOUN	NN	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
10	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
38	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 496
# text = These observations provide additional evidence that oxLDL is a potent modulator of gene expression and suggest that (dys)regulation of NF-kappa B/Rel is likely to play an important role in atherogenesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
11	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	dys	dy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
35	role	role	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 497
# text = Document 003002181 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002181	003002181	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 498
# text = The interleukin-8 AP-1 and kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	8	8	NUM	CD	NumType=Card	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 499
# text = B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	end	end	NOUN	NN	Number=Sing	_	_	_	_
8	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
17	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 500
# text = FK506, an immunosuppressant, inhibits the production of several cytokines in T lymphocytes.
1	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 501
# text = We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
5	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
34	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
37	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 502
# text = By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.
1	By	by	ADP	IN	_	_	_	_	_
2	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	like	like	SCONJ	IN	_	_	_	_	_
22	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 503
# text = FK506 suppressed the transcriptions through the AP-1 or kappa B-like sites induced by PMA plus Ca(2+)-mobilizing agents, but not those induced by Ca(2+)-independent stimuli.
1	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
2	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptions	transcription	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	like	like	SCONJ	IN	_	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
19	plus	plus	CCONJ	CC	_	_	_	_	_
20	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	mobilizing	mobilizing	ADJ	JJ	Degree=Pos	_	_	_	_
26	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	Ca	Ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
39	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 504
# text = In gel retardation analysis, FK506 had little effect on the binding to the AP-1 site of PMA/ionomycin-induced nuclear factors, which were recognized with anti-JunD or c-Fos antibody.
1	In	in	ADP	IN	_	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	PMA/ionomycin-induced	PMA/ionomycin-induced	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	anti-JunD	anti-jund	NOUN	NN	Number=Sing	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Fos	Fos	ADJ	JJ	Degree=Pos	_	_	_	_
33	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 505
# text = In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	EGTA	EGTA	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	chelator	chelator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	similarly	similarly	ADV	RB	_	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	any	any	DET	DT	_	_	_	_	_
31	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
32	against	against	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
36	family	family	NOUN	NN	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 506
# text = Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	confirmed	confirm	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
7	report	report	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
10	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	PMA/ionomycin-induced	PMA/ionomycin-induced	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	authentic	authentic	ADJ	JJ	Degree=Pos	_	_	_	_
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 507
# text = (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	8	8	NUM	CD	NumType=Card	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	SCONJ	IN	_	_	_	_	_
45	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
46	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 508
# text = Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site, but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506-sensitive pathway involving Ca2+ mobilization.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AT	at	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NFIL	Nfil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	A	a	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	8	8	NUM	CD	NumType=Card	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	like	like	SCONJ	IN	_	_	_	_	_
41	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
42	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
43	terminals	terminal	NOUN	NNS	Number=Plur	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
48	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
49	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
50	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	+	+	SYM	SYM	_	_	_	_	_
52	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 509
# text = Document 003002182 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002182	003002182	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 510
# text = Interactions of a transcriptional activator in the env gene of the mouse mammary tumor virus with activation-dependent, T cell-specific transacting factors.
1	Interactions	Interaction	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	env	env	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
13	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	transacting	transacting	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 511
# text = The mouse mammary tumor virus env gene contains a transcriptional activator (META) that can control transcription of the adjacent long terminal repeat region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
3	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	env	env	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 512
# text = Transcriptional control by META parallels that of several lymphokine genes, being specific to T cells, dependent on their activation, and inhibited by the immunosuppressive drug cyclosporine (CsA).
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	META	META	PROPN	NNP	Number=Sing	_	_	_	_
5	parallels	parallel	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	ADV	WRB	PronType=Rel	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
28	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
29	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 513
# text = DNase I footprinting indicated that nuclear factors from activated T lymphocytes bound a promoter-proximal site, META(P), and a promoter-distal site, META(D+), within the 400-base pair META region.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	bound	bound	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	within	within	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	400	400	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	base	base	NOUN	NN	Number=Sing	_	_	_	_
42	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
43	META	Meof	ADP	IN	Abbr=Yes	_	_	_	_
44	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 514
# text = Nuclear factors from unstimulated, but not from activated cells, bound a site, META(D-), adjacent to META(D+).
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	bound	bound	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	+)	+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 515
# text = META(D+) directed transcription of a linked luciferase gene, and gel shift analysis revealed binding of inducible, CsA-sensitive T cell factors, in parallel with transfection results.
1	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	D	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
18	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 516
# text = Authentic NFAT and NF-kappaB targets did not compete for the META(D+) binding factor(s).
1	Authentic	authentic	PROPN	NNP	Number=Sing	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	META	METa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	D	d	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	s	s	X	AFX	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 517
# text = The SV40 core sequence competed for META(D+) binding factors, but META(D+) failed to compete for the complexes obtained with the SV40 probe.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
3	core	core	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	competed	compet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
27	obtained	obtaine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
31	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 518
# text = Our results, taken together, indicate that META(D+) is a novel transcriptional enhancer element that is similar in its cell-type specificity, activation dependence, and CsA sensitivity to the NFAT element.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
25	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	CsA	csa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
40	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 519
# text = It may be relevant to the role of MMTV in expression of Mls antigens or the induction of T cell lymphomas.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Mls	Mls	NOUN	NNS	Number=Plur	_	_	_	_
14	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 520
# text = Document 003002185 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002185	003002185	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 521
# text = Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	upregulate	upregulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 522
# text = BACKGROUND: The immediate early genes (IE) of human cytomegalovirus (CMV) can be expressed in monocytic cells and are known to regulate viral and cellular genes.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IE	ie	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 523
# text = Interleukin-6 (IL-6) plays a central role in numerous inflammatory and immune processes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 524
# text = Interleukin-6 levels are increased in lung transplant patients clinically diagnosed with CMV pneumonitis.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
9	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	clinically	clinically	ADV	RB	_	_	_	_	_
12	diagnosed	diagnose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	CMV	Cmv	PROPN	NNP	Number=Sing	_	_	_	_
15	pneumonitis	pneumonitis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 525
# text = The regulation of IL-6 is dependent on various stimuli that include lipopolysaccharide (LPS), viruses, and other cytokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 526
# text = These studies examined the ability of CMV IE gene products to modulate IL-6 production.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
8	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
10	products	product	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 527
# text = METHODS: THP-1 cells, a monocytic cell line, were transfected with the CMV IE genes.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
18	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 528
# text = Interleukin-6 protein and IL-6 mRNA were measured in control and CMV immediate early transfected cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CMV	Cmv	X	GW	_	_	_	_	_
16	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
17	early	early	ADV	RB	Degree=Pos	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 529
# text = Cotransfection of CMV IE genes and IL-6 chloramphenicol acetyl transferase (CAT) or IL-6 luciferase constructs were used to study IL-6 promoter activity.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
4	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
12	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
21	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 530
# text = RESULTS: Interleukin-6 protein and mRNA production were significantly increased in cells transfected with the CMV IE genes and stimulated with LPS compared to LPS-stimulated control cells.
1	RESULTS	result	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
19	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
25	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 531
# text = Cytomegalovirus
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 532
# text = IE gene products significantly enhanced LPS stimulation of IL-6 promoter activity in both IL-6 CAT and IL-6 luciferase assays.
1	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	products	product	NOUN	NNS	Number=Plur	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
25	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 533
# text = A deletion construct that contains a NF-kappa B site but is missing the multiple response region demonstrated a continued increase in IL-6 luciferase activity in LPS-stimulated CMV transfected cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	missing	miss	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	continued	continu	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	CMV	haCmve	NOUN	NN	Number=Sing	_	_	_	_
34	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 534
# text = CONCLUSION: Cytomegalovirus immediate early gene products significantly enhanced expression of IL-6 in LPS-stimulated cells.
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 535
# text = The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	area	area	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	6	6	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
37	amp	amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
41	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
43	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
44	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 536
# text = The ability of CMV IE gene products to enhance IL-6 production may play an important role in immune inflammatory states associated with CMV infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
5	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	states	state	NOUN	NNS	Number=Plur	_	_	_	_
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	CMV	Cmv	NOUN	NN	Number=Sing	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 537
# text = Document 003002187 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002187	003002187	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 538
# text = Costimulation requirement for AP-1 and NF-kappa B transcription factor activation in T cells.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 539
# text = The transcriptional activity of the IL-2 promoter requires T-cell costimulation delivered by the TCR and the auxiliary receptor CD28.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
11	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
14	delivered	deliver	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	auxiliary	auxiliary	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 540
# text = Several transcription factors participate in IL-2 promoter activation, among which are AP-1-like factors and NF-kappa B. Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the AP-1 protein c-Jun; and (2) it is involved in the release of the cytoplasmic inhibitor, I kappa B, from NF-kappa B, allowing translocation of the latter into the nucleus.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	among	among	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADP	IN	_	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_
27	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
29	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
38	two	two	NUM	CD	NumType=Card	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	:	:	PUNCT	:	_	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	1	1	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
45	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
48	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
55	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	;	;	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	2	2	X	LS	_	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
64	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
65	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
66	in	in	ADP	IN	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	release	release	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
72	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	,	,	PUNCT	,	_	_	_	_	_
74	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
75	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
76	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	,	,	PUNCT	,	_	_	_	_	_
78	from	from	ADP	IN	_	_	_	_	_
79	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
80	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
81	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
82	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	,	,	PUNCT	,	_	_	_	_	_
84	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
85	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
86	of	of	ADP	IN	_	_	_	_	_
87	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
88	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
89	into	into	ADP	IN	_	_	_	_	_
90	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
91	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
92	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 541
# text = We have recently shown that both phosphorylation processes require T-cell costimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
9	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 542
# text = Furthermore, in activated T cells, the kinetics of the two phosphorylation events are essentially similar.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essentially	essentially	ADV	RB	_	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 543
# text = According to our results, however, the kinases responsible for the two processes are distinct entities.
1	According	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	entities	entity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 544
# text = Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B, it markedly enhances the activity of JNK, the MAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	TPCK	TPCK	PROPN	NNP	Number=Sing	_	_	_	_
3	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	markedly	markedly	ADV	RB	_	_	_	_	_
22	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
33	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	phosphorylates	phosphorylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
38	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 545
# text = We, therefore, propose the activation scheme presented in FIGURE 3 for T-cell costimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	propose	propose	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	scheme	scheme	NOUN	NN	Number=Sing	_	_	_	_
9	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	FIGURE	figure	PROPN	NNP	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 546
# text = Costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two transcription factors, AP-1 and NF-kappa B.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 547
# text = Integration of the signals generated by TCR and CD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand, and JNK activation and c-Jun phosphorylation on the other.
1	Integration	Integration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
11	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
12	along	along	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	then	then	ADV	RB	PronType=Dem	_	_	_	_
18	bifurcates	bifurcate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
43	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
44	on	on	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 548
# text = We are currently engaged in defining where the two signals integrate along the AP-1/NF-kappa B pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	currently	currently	ADV	RB	_	_	_	_	_
4	engaged	engage	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	defining	define	VERB	VBG	VerbForm=Ger	_	_	_	_
7	where	where	ADV	WRB	PronType=Int	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	integrate	integrate	ADJ	JJ	Degree=Pos	_	_	_	_
12	along	along	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 549
# text = Document 003002190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002190	003002190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 550
# text = The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
7	product	product	NOUN	NN	Number=Sing	_	_	_	_
8	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
9	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	engages	engage	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	death	death	NOUN	NN	Number=Sing	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
28	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 551
# text = The Epstein-Barr virus latent membrane protein 1 (LMP1) is essential for the transformation of B lymphocytes into lymphoblastoid cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 552
# text = Previous data are consistent with a model that LMP1 is a constitutively activated receptor that transduces signals for transformation through its carboxyl-terminal cytoplasmic tail.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	model	model	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	constitutively	constitutively	ADV	RB	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	transduces	transduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
26	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 553
# text = One transformation effector site (TES1), located within the membrane proximal 45 residues of the cytoplasmic tail, constitutively engages tumor necrosis factor receptor-associated factors.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
3	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TES1	TES1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
13	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
14	45	45	NUM	CD	NumType=Card	_	_	_	_
15	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
19	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	constitutively	constitutively	ADV	RB	_	_	_	_	_
22	engages	engage	NOUN	NNS	Number=Plur	_	_	_	_
23	tumor	tumor	ADP	IN	_	_	_	_	_
24	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 554
# text = Signals from TES1 are sufficient to drive initial proliferation of infected resting B lymphocytes, but most lymphoblastoid cells infected with a virus that does not express the 155 residues beyond TES1 fail to grow as long-term cell lines.
1	Signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	TES1	tES1	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	drive	drive	VERB	VB	VerbForm=Inf	_	_	_	_
8	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
9	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	most	most	ADV	RBS	_	_	_	_	_
18	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	155	155	NUM	CD	NumType=Card	_	_	_	_
30	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
31	beyond	beyond	ADP	IN	_	_	_	_	_
32	TES1	TES1	NUM	CD	NumType=Card	_	_	_	_
33	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	grow	grow	VERB	VB	VerbForm=Inf	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	term	term	NOUN	NN	Number=Sing	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 555
# text = We now find that mutating two tyrosines to an isoleucine at the carboxyl end of the cytoplasmic tail cripples the ability of EBV to cause lymphoblastoid cell outgrowth, thereby marking a second transformation effector site, TES2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mutating	mutat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	tyrosines	tyrosine	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
14	end	end	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
18	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
19	cripples	cripple	NOUN	NNS	Number=Plur	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
26	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	outgrowth	outgrowth	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	thereby	thereby	ADV	RB	_	_	_	_	_
31	marking	mark	VERB	VBG	VerbForm=Ger	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
34	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
35	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	TES2	TES2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 556
# text = A yeast two-hybrid screen identified TES2 interacting proteins, including the tumor necrosis factor receptor-associated death domain protein (TRADD).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
6	screen	screen	NOUN	NN	Number=Sing	_	_	_	_
7	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	TES2	TES2	NUM	CD	NumType=Card	_	_	_	_
9	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	death	death	NOUN	NN	Number=Sing	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TRADD	TRADD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 557
# text = TRADD was the only protein that interacted with wild-type TES2 and not with isoleucine-mutated TES2.
1	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	TES2	Tes2	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	TES2	Tes2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 558
# text = TRADD associated with wild-type LMP1 but not with isoleucine-mutated LMP1 in mammalian cells, and TRADD constitutively associated with LMP1 in EBV-transformed cells.
1	TRADD	Tradd	NOUN	NN	Number=Sing	_	_	_	_
2	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	isoleucine-mutated	isoleucine-mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	TRADD	TRADD	PROPN	NNP	Number=Sing	_	_	_	_
19	constitutively	constitutively	ADV	RB	_	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 559
# text = In transfection assays, TRADD and TES2 synergistically mediated high-level NF-kappaB activation.
1	In	in	ADP	IN	_	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	TRADD	Tradd	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TES2	TES2	NUM	CD	NumType=Card	_	_	_	_
8	synergistically	synergistically	ADV	RB	_	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 560
# text = These results indicate that LMP1 appropriates TRADD to enable efficient long-term lymphoblastoid cell outgrowth.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
6	appropriates	appropriate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	TRADD	TRADD	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enable	enable	VERB	VB	VerbForm=Inf	_	_	_	_
10	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	term	term	NOUN	NN	Number=Sing	_	_	_	_
14	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 561
# text = High-level NF-kappaB activation also appears to be a critical component of long-term outgrowth.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	level	level	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	component	component	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	term	term	NOUN	NN	Number=Sing	_	_	_	_
19	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 562
# text = Document 003002194 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002194	003002194	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 563
# text = Antisense oligonucleotides to the p65 subunit of NF-kappa B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes.
1	Antisense	Antisense	ADJ	JJ	Degree=Pos	_	_	_	_
2	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
6	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	block	block	NOUN	NN	Number=Sing	_	_	_	_
13	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	b	b	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	alter	alter	NOUN	NN	Number=Sing	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	60	60	NUM	CD	NumType=Card	_	_	_	_
26	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 564
# text = NF-kappa B is a pleiotropic regulator of a variety of genes implicated in the cellular response to injury.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 565
# text = This function has been attributed to the coordinated binding of subunits of NF-kappa B to distinct regions of the promoter elements of numerous genes, including cytokines, growth factor receptors, and adhesion molecules.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
19	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 566
# text = Antisense phosphorothioate oligonucleotides to the p50 and p65 subunits of the NF-kappa B complex were used to define the physiologic role of this transcription factor in resting and stimulated granulocytes.
1	Antisense	Antisense	ADJ	JJ	Degree=Pos	_	_	_	_
2	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
3	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	p65	p65	NUM	CD	NumType=Card	_	_	_	_
9	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	SCONJ	IN	_	_	_	_	_
29	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 567
# text = A reduction in the expression of p65 was produced by treatment with the phosphorothioate antisense oligodeoxynucleotide.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
15	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
16	oligodeoxynucleotide	oligodeoxynucleotide	ADV	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 568
# text = This reduction was accompanied by rapid changes in the cellular adhesion of dimethyl sulfoxide-differentiated HL-60 leukemia cells stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	dimethyl	dimethyl	NOUN	NN	Number=Sing	_	_	_	_
14	sulfoxide	sulfoxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	60	60	NUM	CD	NumType=Card	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
29	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 569
# text = These effects were characterized by a marked reduction in CD11b integrin expression on the surface of treated cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	b	benefit	NOUN	NN	Number=Sing	_	_	_	_
13	integrin	integrin	ADP	IN	_	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 570
# text = Furthermore, the p65 antisense oligomer effectively abolished an upregulation of CD11b that was produced by formyl-met-leu-phe and TPA.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
5	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
6	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	_
7	effectively	effectively	ADV	RB	_	_	_	_	_
8	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	b	b	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	formyl	formyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	met	meet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	leu	leu	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	phe	phe	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 571
# text = However, the p65 antisense phosphorothioate oligodeoxynucleotide had no significant effect on the production of reactive oxygen intermediates or on phagocytosis by these cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
5	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
7	oligodeoxynucleotide	oligodeoxynucleotide	ADV	RB	_	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
18	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 572
# text = These findings indicate that antisense oligomers to p65 can be used to define the role of NF-kappa B in the activation pathways of neutrophils.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
6	oligomers	oligomer	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 573
# text = Document 003002196 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002196	003002196	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 574
# text = ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha.
1	ETS	ets	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 575
# text = We describe an enhancer site in the third intron of tumor necrosis factor alpha (TNF-alpha).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 576
# text = A reporter construct containing the 5'-flanking region of the mouse TNF-alpha gene displayed weak activity when transfected into RAW264.7 macrophage-like cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
3	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	when	when	ADV	WRB	PronType=Int	_	_	_	_
22	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	into	into	ADP	IN	_	_	_	_	_
24	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
26	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 577
# text = The addition of the third intron of TNF-alpha to this construct resulted in an enhancement of CAT protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
14	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 578
# text = This enhancement was eliminated if a conserved 20-bp sequence was removed from the intron or if a dominant-negative ets-binding factor was co-transfected with the reporter gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	eliminated	eliminate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	if	if	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	removed	remove	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	if	if	SCONJ	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
23	ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 579
# text = Mutations of this site that destroyed potential ets transcription factor binding sites had reduced transcriptional activity.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	destroyed	destroy	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
8	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 580
# text = The major transcription factor that bound to the oligonucleotide was confirmed to be GABP by supershift and competition analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 581
# text = In RAW264.7 cells, the binding was constitutive, however, in bone marrow-derived macrophages binding activity was shown to be interferon-gamma inducible.
1	In	in	ADP	IN	_	_	_	_	_
2	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
15	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	interferon	interferon	ADP	IN	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
28	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 582
# text = This may imply a role for ets transcription factors in the production of TNF-alpha.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	imply	imply	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 583
# text = Document 003002199 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002199	003002199	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 584
# text = Xenogeneic human serum promotes leukocyte adhesion to porcine endothelium under flow conditions, possibly through the activation of the transcription factor NF-kappa B.
1	Xenogeneic	Xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
4	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	porcine	porcine	VERB	VB	VerbForm=Inf	_	_	_	_
9	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
10	under	under	ADP	IN	_	_	_	_	_
11	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
12	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	possibly	possibly	ADV	RB	_	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 585
# text = Endothelial cell activation and leukocyte infiltration are a consistent feature of discordant xenograft rejection.
1	Endothelial	Endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
6	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	discordant	discordant	ADJ	JJ	Degree=Pos	_	_	_	_
13	xenograft	xenograft	NOUN	NN	Number=Sing	_	_	_	_
14	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 586
# text = Here we evaluated whether xenogeneic serum, as a source of xenoreactive natural antibodies and complement, induced endothelial cell activation with consequent leukocyte adhesion under flow conditions.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
6	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	source	source	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	xenoreactive	xenoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	complement	complement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
28	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 587
# text = Porcine aortic endothelial cells (PAEC) were incubated for 1 hr 30 min or 5 hr with 10% homologous porcine serum (control) or 10% xenogeneic human serum and then perfused with total human leukocytes in a parallel plate flow chamber under laminar flow (1.5 dynes/cm2).
1	Porcine	Porcine	PROPN	NNP	Number=Sing	_	_	_	_
2	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
13	30	30	NUM	CD	NumType=Card	_	_	_	_
14	min	min	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	%	%	SYM	NN	Number=Sing	_	_	_	_
21	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
22	porcine	porcine	NOUN	NN	Number=Sing	_	_	_	_
23	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	%	%	SYM	NN	Number=Sing	_	_	_	_
30	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	then	then	ADV	RB	PronType=Dem	_	_	_	_
35	perfused	perfuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
43	plate	plate	NOUN	NN	Number=Sing	_	_	_	_
44	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
45	chamber	chamber	NOUN	NN	Number=Sing	_	_	_	_
46	under	under	ADP	IN	_	_	_	_	_
47	laminar	laminar	ADJ	JJ	Degree=Pos	_	_	_	_
48	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	1.5	1.5	NUM	CD	NumType=Card	_	_	_	_
51	dynes	dyne	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
53	cm2	cm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 588
# text = Adherent cells were counted by digital image analysis.
1	Adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	counted	count	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	digital	digital	ADJ	JJ	Degree=Pos	_	_	_	_
7	image	image	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 589
# text = Xenogeneic human serum significantly (P < 0.01) increased the number of adherent leukocytes as compared with porcine serum.
1	Xenogeneic	Xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	p	NOUN	NN	Number=Sing	_	_	_	_
7	<	<	PUNCT	-LRB-	_	_	_	_	_
8	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	number	number	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	porcine	porcine	NOUN	NN	Number=Sing	_	_	_	_
20	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 590
# text = A similar adhesive response was elicited by TNF alpha (100 U/ml), one of the most potent inducers of endothelial cell adhesive properties, here used as positive control.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	100	100	NUM	CD	NumType=Card	_	_	_	_
12	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	most	most	ADV	RBS	_	_	_	_	_
20	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
21	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
26	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	here	here	ADV	RB	PronType=Dem	_	_	_	_
29	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 591
# text = In order to elucidate possible mechanisms underlying endothelial cell activation by xenogeneic serum, we focussed on transcription factor NF-kappa B, a central regulator for the induction of different genes, including adhesive molecules and chemoattractants.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	focussed	focuss	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
27	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
36	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	chemoattractants	chemoattractant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 592
# text = By confocal fluorescence microscopy, we observed a positive staining for NF-kappa B (p65 subunit) in the nuclei of PAEC exposed for 1 hr 30 min to human serum, which indicated NF-kappa B activation in this setting.
1	By	by	ADP	IN	_	_	_	_	_
2	confocal	confocal	ADJ	JJ	Degree=Pos	_	_	_	_
3	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
4	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p65	p65	NUM	CD	NumType=Card	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
25	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
29	30	30	NUM	CD	NumType=Card	_	_	_	_
30	min	min	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	setting	setting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 593
# text = At variance, in PAEC incubated with the homologous serum, NF-kappa B was strictly localized in the cell cytoplasm.
1	At	at	ADP	IN	_	_	_	_	_
2	variance	variance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
6	incubated	incubate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
10	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	strictly	strictly	ADV	RB	_	_	_	_	_
18	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 594
# text = Treatment of PAEC exposed to xenogeneic serum with the NF-kappa B inhibitors pyrrolidinedithiocarbamate (PDTC, 25 microM) and tosyl-phechloromethylketone (TPCK, 25 microM) significantly (P < 0.01) reduced leukocyte adhesion in respect to PAEC treated with human serum alone.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
4	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
7	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
15	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	25	25	NUM	CD	NumType=Card	_	_	_	_
20	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	tosyl	tosyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	phechloromethylketone	phechloromethylketone	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TPCK	TPCK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	25	25	NUM	CD	NumType=Card	_	_	_	_
30	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	significantly	significantly	ADV	RB	_	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	P	p	NOUN	NN	Number=Sing	_	_	_	_
35	<	<	PUNCT	-LRB-	_	_	_	_	_
36	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
40	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
45	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
49	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 595
# text = Findings that xenogeneic serum promotes leukocyte-endothelium interaction possibly through NF-kappa B activation might be relevant for designing future therapeutic strategies aimed at prolonging xenograft survival.
1	Findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	SCONJ	IN	_	_	_	_	_
3	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
4	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
5	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	possibly	possibly	ADV	RB	_	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	designing	design	VERB	VBG	VerbForm=Ger	_	_	_	_
22	future	future	ADJ	JJ	Degree=Pos	_	_	_	_
23	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
24	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
25	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	at	at	SCONJ	IN	_	_	_	_	_
27	prolonging	prolonge	VERB	VBG	VerbForm=Ger	_	_	_	_
28	xenograft	xenograft	NOUN	NN	Number=Sing	_	_	_	_
29	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 596
# text = Document 003002202 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002202	003002202	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 597
# text = Epstein-Barr virus replicative gene transcription during de novo infection of human thymocytes: simultaneous early expression of BZLF-1 and its repressor RAZ.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	de	de	PROPN	NNP	Number=Sing	_	_	_	_
10	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
17	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	BZLF	BZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
26	RAZ	Raz	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 598
# text = Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 599
# text = We and others have shown that EBV can also infect a subset of thymocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	others	other	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 600
# text = Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	linear	linear	NOUN	NN	Number=Sing	_	_	_	_
11	EBV	EBV	NOUN	NN	Number=Sing	_	_	_	_
12	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	8	8	NUM	CD	NumType=Card	_	_	_	_
15	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 601
# text = Circularization of the EBV genome was not detected.
1	Circularization	Circularization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
5	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 602
# text = This is in contrast to the infection in B cells where the genome can circularize within 24 hr of infection.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	where	where	ADV	WRB	PronType=Rel	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	circularize	circularize	VERB	VB	VerbForm=Inf	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	24	24	NUM	CD	NumType=Card	_	_	_	_
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 603
# text = The appearance of the BamHI ZLF-1 gene product, ZEBRA, by RT-PCR, was observed within 8 hr of infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	_
6	ZLF	ZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	8	8	NUM	CD	NumType=Card	_	_	_	_
23	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 604
# text = The appearance of a novel fusion transcript (RAZ), which comprised regions of the BZLF-1 locus and the adjacent BRLF-1 locus, was detected by RT-PCR.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RAZ	RAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	comprised	comprise	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	BZLF	BZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
24	BRLF	BRLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 605
# text = ZEBRA protein was also identified in infected thymocytes by immunoprecipitation.
1	ZEBRA	zebra	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 606
# text = In addition, we demonstrated that the EBNA-1 gene in infected thymocytes was transcribed from the Fp promoter, rather than from the Cp/Wp promoter which is used in latently infected B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	infected	infected	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Fp	Fp	PROPN	NNP	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	rather	rather	ADV	RB	_	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Cp/	cp/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	Wp	Wp	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	latently	latently	ADV	RB	_	_	_	_	_
34	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 607
# text = Transcripts encoding gp350/220, the major coat protein of EBV, were identified, but we did not find any evidence of transcription from the LMP-2A or EBER-1 loci in infected thymocytes.
1	Transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
2	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
3	gp350	gp350	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
5	220	220	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	coat	coat	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
22	any	any	DET	DT	_	_	_	_	_
23	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	EBER	EBER	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
38	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 608
# text = These observations suggest that de novo EBV infection of thymocytes differs from infection of B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	de	de	PROPN	NNP	Number=Sing	_	_	_	_
6	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 609
# text = The main difference is that with thymocytes, no evidence could be found that the virus ever circularizes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
3	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	ever	ever	ADV	RB	_	_	_	_	_
18	circularizes	circularize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 610
# text = Rather, EBV remains in a linear configuration from which replicative genes are transcribed.
1	Rather	Rather	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
4	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	linear	linear	NOUN	NN	Number=Sing	_	_	_	_
8	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 611
# text = Document 003002203 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002203	003002203	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 612
# text = Second messenger up-regulation of androgen receptor gene transcription is absent in androgen insensitive human prostatic carcinoma cell lines, PC-3 and DU-145.
1	Second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
2	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
3	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	androgen	androgen	NUM	CD	NumType=Card	_	_	_	_
15	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
18	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	DU	du	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	145	145	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 613
# text = A theoretical pathway of transcriptional regulation of the androgen receptor (AR) gene is via a cAMP response element (CRE) present in its promoter region (-508 to -501).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	theoretical	theoretical	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	AR	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	region	region	NOUN	NN	Number=Sing	_	_	_	_
29	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
30	508	508	NUM	CD	NumType=Card	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	501	501	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 614
# text = After 20 h of stimulation with 8-bromo-cAMP, AR mRNA was upregulated in LNCaP but not in either PC-3 or DU-145 cell lines.
1	After	after	ADP	IN	_	_	_	_	_
2	20	20	NUM	CD	NumType=Card	_	_	_	_
3	h	h	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	bromo-cAMP	bromo-camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	AR	ar	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	LNCaP	LNCaP	NOUN	NN	Number=Sing	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	either	either	DET	DT	_	_	_	_	_
21	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	DU	do	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	145	145	NUM	CD	NumType=Card	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 615
# text = We have demonstrated that the level of CRE binding protein (CREB) was the same in all cell lines and that the putative AR-CRE forms specific and compatible protein interactions with CREB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CRE	Cre	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	all	all	DET	DT	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
25	AR	ar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
28	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 616
# text = The ability to regulate AR gene transcription via the second messenger pathway is lost in the PC-3 and DU-145 cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
5	AR	be	ADP	IN	_	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	via	via	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	DU	do	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	145	145	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 617
# text = This may be an important primary mechanism of androgen insensitivity in prostate cancer.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
10	insensitivity	insensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	prostate	prostate	ADJ	JJ	Degree=Pos	_	_	_	_
13	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 618
# text = Document 003002213 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002213	003002213	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 619
# text = Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
4	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 620
# text = Intracellular signals that mediate differentiation of pluripotent hemopoietic progenitors to dendritic cells (DC) are largely undefined.
1	Intracellular	Intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	pluripotent	pluripotent	ADJ	JJ	Degree=Pos	_	_	_	_
8	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
9	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	largely	largely	ADV	RB	_	_	_	_	_
18	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 621
# text = We have previously shown that protein kinase C (PKC) activation (with phorbol ester (PMA) alone) specifically induces differentiation of primary human CD34+ hemopoietic progenitor cells (HPC) to mature DC.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	with	with	ADP	IN	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	specifically	specifically	ADV	RB	_	_	_	_	_
23	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	CD34	Cd34	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
31	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	mature	mature	VERB	VB	VerbForm=Inf	_	_	_	_
38	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 622
# text = We now find that cytokine-driven (granulocyte-macrophage CSF and TNF-alpha) CD34+ HPC-->
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	driven	driven	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
12	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	CD34	CD34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	HPC	HPC	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
21	-->	-->	SYM	NFP	_	_	_	_	SpaceAfter=No

# sent_id = 623
# text = DC differentiation is preferentially blocked by inhibitors of PKC activation.
1	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	preferentially	preferentially	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 624
# text = To further identify intracellular signals and downstream events important in CD34+ HPC-->
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
4	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-->	-->	SYM	NFP	_	_	_	_	SpaceAfter=No

# sent_id = 625
# text = DC differentiation we have characterized a human leukemic cell line model of this process.
1	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 626
# text = The CD34+ myelomonocytic cell line KG1 differentiates into dendritic-like cells in response to granulocyte-macrophage CSF plus TNF-alpha, or PMA (with or without the calcium ionophore ionomycin, or TNF-alpha), with different stimuli mediating different aspects of the process.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	+	+	SYM	SYM	_	_	_	_	_
4	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	KG1	KG1	PROPN	NNP	Number=Sing	_	_	_	_
8	differentiates	differentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	granulocyte	granulocyte	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
21	plus	plus	CCONJ	CC	_	_	_	_	_
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	with	with	ADP	IN	_	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	without	without	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
34	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
35	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
45	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
46	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
47	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
48	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 627
# text = Phenotypic DC characteristics of KG1 dendritic-like cells include morphology (loosely adherent cells with long neurite processes), MHC I+/MHC
1	Phenotypic	Phenotypic	PROPN	NNP	Number=Sing	_	_	_	_
2	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
3	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	KG1	KG1	NUM	CD	NumType=Card	_	_	_	_
6	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	loosely	loosely	ADV	RB	_	_	_	_	_
14	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	neurite	neurite	NOUN	NN	Number=Sing	_	_	_	_
19	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	+/MHC	+/MHC	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 628
# text = IIbright/CD83+/CD86+/CD14- surface
1	IIbright/CD83+/CD86+/CD14	IIbright/CD83+/CD86+/CD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	_
3	surface	surface	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 629
# text = Ag expression, and RelB and DC-CK1 gene expression.
1	Ag	ag	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CK1	CK1	PROPN	NNP	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 630
# text = Functional DC characteristics include fluid phase macromolecule uptake (FITC-dextran) and activation of resting T cells.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
3	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
4	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	fluid	fluid	ADJ	JJ	Degree=Pos	_	_	_	_
6	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
7	macromolecule	macromolecule	NOUN	NN	Number=Sing	_	_	_	_
8	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FITC	Fitc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dextran	dextran	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 631
# text = Comparison of KG1 to the PMA-unresponsive subline KG1a reveals differences in expression of TNF receptors 1 and 2; PKC isoforms alpha, beta I, beta II, and mu; and RelB, suggesting that these components/pathways are important for DC differentiation.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	KG1	KG1	NUM	CD	NumType=Card	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
9	subline	subline	NOUN	NN	Number=Sing	_	_	_	_
10	KG1	KG1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	reveals	reveal	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
24	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
25	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	beta	beto	INTJ	UH	_	_	_	_	_
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
31	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	mu	mu	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
45	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
49	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 632
# text = Together, these findings demonstrate that cytokine or phorbol ester stimulation of KG1 is a model of human CD34+ HPC to DC differentiation and suggest that specific intracellular signaling pathways mediate specific events in DC lineage commitment.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
10	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	KG1	KG1	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	model	model	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
32	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	events	event	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
37	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
38	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 633
# text = Document 003002219 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002219	003002219	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 634
# text = Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	vanadate	vanadate	ADJ	JJ	Degree=Pos	_	_	_	_
11	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 635
# text = Rapid tyrosine phosphorylation of key cellular proteins is a crucial event in the transduction of activation signals to T-lymphocytes.
1	Rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
11	event	event	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 636
# text = The regulatory role of protein tyrosine phosphatases (PTPases) in this process was explored by studying the effects of a powerful PTPase inhibitor, vanadate peroxide (pervanadate), on the activation cascade of Jurkat human leukaemic T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PTPases	PTPase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	process	process	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
23	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
24	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
27	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	pervanadate	pervanadate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukaemic	leukaemic	ADJ	JJ	Degree=Pos	_	_	_	_
40	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 637
# text = Pervanadate induced activation of the tyrosine kinases lck and fyn (4- and 3-fold respectively) and a dramatic increase in tyrosine phosphorylation of cellular proteins, notably phospholipase C gamma 1.
1	Pervanadate	Pervanadate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	lck	lck	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	fyn	fyn	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
18	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
26	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	notably	notably	ADV	RB	_	_	_	_	_
32	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	_
34	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 638
# text = After this event, we observed a rise in intracellular Ca2+ concentration, corresponding to an influx.
1	After	after	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	influx	influx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 639
# text = This effect required surface expression of the CD45 PTPase and was not observed in CD45-deficient variants of Jurkat cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
9	PTPase	PTPase	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
18	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 640
# text = In the CD45-negative variant, the effect of pervanadate on tyrosine phosphorylation was globally decreased and some phosphorylated substrates were specifically missing.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	CD45	Cd45	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	variant	variant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	pervanadate	pervanadate	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	globally	globally	ADV	RB	_	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	_
20	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	specifically	specifically	ADV	RB	_	_	_	_	_
24	missing	missing	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 641
# text = Pervanadate also stimulated transcription of the c-fos gene and accumulation of its mRNA as well as several other hallmarks of T-lymphocyte activation such as surface expression of the CD69 antigen and the interleukin 2 receptor alpha-chain (CD25).
1	Pervanadate	Pervanadate	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	hallmarks	hallmark	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	CD69	CD69	PROPN	NNP	Number=Sing	_	_	_	_
33	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	CD25	CD25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 642
# text = Pervanadate synergized with signals delivered by T-cell antigen receptor engagement or by a phorbol ester to induce interleukin 2 production.
1	Pervanadate	Pervanadate	NOUN	NN	Number=Sing	_	_	_	_
2	synergized	synergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	delivered	deliver	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
16	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	interleukin	interleukin	ADV	RB	_	_	_	_	_
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 643
# text = Pervanadate activated NF-kappa B, as shown by an increase in DNA-binding activity of this transcription factor.
1	Pervanadate	Pervanadate	PROPN	NNP	Number=Sing	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	as	as	SCONJ	IN	_	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 644
# text = We thus conclude that PTPases play a crucial role in the negative regulation of signal transduction culminating in T-lymphocyte activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	thus	thus	ADV	RB	_	_	_	_	_
3	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PTPases	PTPase	PROPN	NNPS	Number=Plur	_	_	_	_
6	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	culminating	culminat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 645
# text = Moreover, induction of tyrosine phosphorylation appears sufficient per se to initiate a complete activation programme.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	per	per	ADP	IN	_	_	_	_	_
10	se	se	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	programme	programme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 646
# text = Document 003002221 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002221	003002221	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 647
# text = Relationship between IkappaBalpha constitutive expression, TNFalpha synthesis, and apoptosis in EBV-infected lymphoblastoid cells.
1	Relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 648
# text = In order to understand the role of NF-kappaB in EBV transformation we have established stably transfected IkappaBalpha into lymphoblastoid cells.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
13	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	stably	stably	ADV	RB	_	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	into	into	ADP	IN	_	_	_	_	_
21	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 649
# text = Two clones were obtained in which the loss of NF-kappaB binding activity correlated with the constitutive expression of the transgenic IkappaBalpha.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
23	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 650
# text = Protein latency expression was determined by immunocytochemistry.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	immunocytochemistry	immunocytochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 651
# text = Expression of surface markers, intracytoplasmic content of cytokines cell cycle analysis after BrdU incorporation and DNA staining with propidium iodide were studied by flow cytometry.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
4	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
7	content	content	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
12	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	BrdU	Brdu	PROPN	NNP	Number=Sing	_	_	_	_
15	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	propidium	propidium	NOUN	NN	Number=Sing	_	_	_	_
21	iodide	iodide	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
26	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 652
# text = Percentage of apoptotic cells was determined by in-situ labelling of DNA strand breaks.
1	Percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
11	labelling	labelling	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	strand	strand	NOUN	NN	Number=Sing	_	_	_	_
15	breaks	break	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 653
# text = No significative changes in EBV latency nor in cell surface marker expression was found.
1	No	no	DET	DT	_	_	_	_	_
2	significative	significative	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	latency	latency	PROPN	NNP	Number=Sing	_	_	_	_
7	nor	nor	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 654
# text = In contrast, intracytoplasmic TNFalpha levels were strongly reduced in transfected clones.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
5	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	strongly	strongly	ADV	RB	_	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 655
# text = Furthermore, 30% of IkappaBalpha transfected cells were apoptotic after 8 h of TNFalpha treatment.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	%	%	SYM	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 656
# text = This correlated with a strong reduction of BrdU incorporation after 24 h of TNFalpha treatment.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
6	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	BrdU	BrdU	PROPN	NNP	Number=Sing	_	_	_	_
9	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	24	24	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 657
# text = No effect was seen with non transfected cells or with cells transfected with a control plasmid.
1	No	no	DET	DT	_	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	non	non	X	AFX	_	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 658
# text = Our results suggest that the TNFalpha gene could be one of the targets of NF-kappaB in EBV infected cells and that NF-kappaB protects EBV-infected cells from apoptosis induced by TNFalpha, which may favour the proliferative effect of this cytokine.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TNFalpha	TNFalpha	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	one	one	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	protects	protects	NOUN	NNS	Number=Plur	_	_	_	_
28	EBV	haEbve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	favour	favour	VERB	VB	VerbForm=Inf	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
43	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
46	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 659
# text = Document 003002228 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002228	003002228	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 660
# text = Involvement of the N-terminal region of the human mineralocorticoid receptor hormone-binding domain in agonist and antagonist binding as revealed by a new monoclonal antibody.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	mineralocorticoid	mineralocorticoid	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
26	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
27	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 661
# text = To gain a better understanding of the mechanism of binding to the human mineralocorticoid receptor (hMR), we developed a new monoclonal antibody (mAb) raised against the hormone-binding domain (HBD).
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
5	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	mineralocorticoid	mineralocorticoid	NOUN	NN	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	hMR	hMR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
24	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
25	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	raised	raise	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	against	against	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	HBD	HBD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 662
# text = For this purpose, mice were immunized with a fusion protein including the sequence Thr729-Lys984 of hMR.
1	For	for	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	immunized	immunize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	Thr729	Thr729	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	Lys984	lys984	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	hMR	hMR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 663
# text = After ELISA screening, mAb 18C7 was selected for its specificity towards the HBD.
1	After	after	SCONJ	IN	_	_	_	_	_
2	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
3	screening	scree	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
6	18C7	18C7	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	selected	select	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
12	towards	towards	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	HBD	hbd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 664
# text = This antibody recognized both the denatured and native MR forms, as well as the hetero-oligomeric MR form and the transformed MR state.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
3	recognized	recognize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	denatured	denatured	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
9	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
10	forms	form	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	hetero	hetero	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	oligomeric	oligomeric	ADJ	JJ	Degree=Pos	_	_	_	_
19	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
20	form	form	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
25	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 665
# text = By using several HBD subfragments, the mAb 18C7 epitope was located in the N-terminal region of the HBD from Thr729 to Leu765.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
4	HBD	hbd	NOUN	NN	Number=Sing	_	_	_	_
5	subfragments	subfragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
9	18C7	18C7	NUM	CD	NumType=Card	_	_	_	_
10	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	HBD	hbd	PROPN	NNP	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	Thr729	Thr729	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	Leu765	Leu765	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 666
# text = We then studied the effect of the antibody on aldosterone and progesterone binding to the hMR.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	then	then	ADV	RB	PronType=Dem	_	_	_	_
3	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	hMR	hmr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 667
# text = When 18C7 was incubated with liganded MR, it was able to partly displace (20%) the hormone from its binding site.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	18C7	18C7	NUM	CD	NumType=Card	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	liganded	ligand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	MR	mr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	partly	partly	VERB	VB	VerbForm=Inf	_	_	_	_
14	displace	displace	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 668
# text = When 18C7 was incubated with MR before aldosterone or progesterone, the antibody inhibited 75-80% of the binding.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	18C7	18C7	NUM	CD	NumType=Card	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	MR	mr	PROPN	NNP	Number=Sing	_	_	_	_
7	before	before	ADP	IN	_	_	_	_	_
8	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 669
# text = The effect of 18C7 on the binding was similar with both hormones.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	18C7	18C7	NUM	CD	NumType=Card	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 670
# text = A sucrose gradient analysis indicated the simultaneous presence of two kinds of receptor complexes: the steroid-MR complex and the antibody-MR complex.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	sucrose	sucrose	NOUN	NN	Number=Sing	_	_	_	_
3	gradient	gradient	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	kinds	kind	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 671
# text = After its associated proteins, especially the heat-shock protein hsp90, had been cross-linked with the hMR by dimethylpimelimidate, 18C7 was still able to react with the receptor.
1	After	after	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
3	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	especially	especially	ADV	RB	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	heat	heat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cross	cross	ADV	RB	_	_	_	_	SpaceAfter=No
18	-linked	-linked	ADJ	JJ	Degree=Pos	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	hMR	hmr	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	dimethylpimelimidate	dimethylpimelimidate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	18C7	18C7	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	still	still	ADV	RB	_	_	_	_	_
28	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	react	react	VERB	VB	VerbForm=Inf	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 672
# text = Our results indicated that the epitope recognized by 18C7 was directly implicated in hormone binding.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	_
7	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	18C7	18C7	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	directly	directly	ADV	RB	_	_	_	_	_
12	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 673
# text = The lack of steroid binding of HBD mutants with the Thr729-Leu765 sequence deleted [Jalaguier, Mesnier, Leger and Auzou (1996) J.Steroid Biochem.Mol.Biol.57, 43-50] supports this hypothesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HBD	Hbd	PROPN	NNP	Number=Sing	_	_	_	_
8	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Thr729	Thr729	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Leu765	Leu765	PROPN	NNP	Number=Sing	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	deleted	delete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	Jalaguier	Jalaguier	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Mesnier	Mesnier	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Leger	Leger	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	Auzou	Auzou	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	1996	1996	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	J.Steroid	J.Steroid	PROPN	NNP	Number=Sing	_	_	_	_
28	Biochem.Mol.Biol	Biochem.Mol.Biol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.57	.57	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	43	43	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	]	]	PUNCT	-RRB-	_	_	_	_	_
35	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 674
# text = Because of the similar behaviours of aldosterone and progesterone, we conclude that the N-terminal Thr729-Leu765 region of the HBD is similarly involved in the binding of both hormones.
1	Because	because	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
5	behaviours	behaviour	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	Thr729	Thr729	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	Leu765	Leu765	NUM	CD	NumType=Card	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	HBD	hbd	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	similarly	similarly	ADV	RB	_	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 675
# text = Document 003002230 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002230	003002230	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 676
# text = High molecular weight dextran sulfate increases the activity of NF-kappaB-regulated promoter in monocyte-derived macrophages.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
4	dextran	dextrun	NOUN	NN	Number=Sing	_	_	_	_
5	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
6	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 677
# text = It is known that sulfated polysaccharides can mimic the action of common T-cell mitogens.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	sulfated	sulfate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	polysaccharides	polysaccharide	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 678
# text = To investigate the molecular basis of the mitogenic effect of high molecular weight dextran sulfate (HMDS), monocyte-derived macrophages were transfected with recombinant plasmid containing chloramphenicol acetyl transferase (CAT) reporter gene under the control of the HIV-1 long terminal repeat (LTR) promoter, which is regulated by transcription factor NF-kappaB.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
14	dextran	dextran	NOUN	NN	Number=Sing	_	_	_	_
15	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HMDS	hmds	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
28	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
29	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
30	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
31	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
32	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
37	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	under	under	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	control	control	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
47	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
48	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	which	which	PRON	WDT	PronType=Rel	_	_	_	_
55	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
56	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
59	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
60	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 679
# text = We observed that HMDS, similar to bacterial lipopolysaccharide (LPS), increases the expression of CAT reporter gene suggesting increased activity of NF-kappaB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HMDS	HMDS	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
19	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	suggesting	suggeste	VERB	VBG	VerbForm=Ger	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 680
# text = The activation of NF-kappaB correlated with the increased expression of B7.1 molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	B7.1	B7.1	NUM	CD	NumType=Card	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 681
# text = It was postulated that this NF-kappaB-regulated promoter might play a role in the activation of the accessory cells as well as the rate of replication of HIV-1 in monocyte-derived macrophages.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	kappaB-	kappaB-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 682
# text = Document 003002237 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002237	003002237	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 683
# text = ETS1 transactivates the human GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin.
1	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	_
2	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 684
# text = Activation of T helper cells results in coordinate expression of a number of cytokines involved in differentiation, proliferation and activation of the haematopoietic system.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	number	number	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	haematopoietic	haematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 685
# text = Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one such cytokine whose increased expression results partly from increases in transcription.
1	Granulocyte	Granulocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
18	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	partly	partly	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 686
# text = Cis-acting elements with NF kappa B, AP-1 and ETS-like motifs have been identified in the promoter region of the GM-CSF gene, which are important for transcriptional activity following PMA and ionomycin stimulation.
1	Cis	Cis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	SCONJ	IN	_	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
39	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	ionomycin	ionomycin	ADP	IN	_	_	_	_	_
42	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 687
# text = A number of the ETS family of transcription factors are expressed in T cells, including ETS1 and ELF1.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	ELF1	ELF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 688
# text = Here we describe the ability of these factors to interact with a site (GM5), located within the CLE0 element, -47 to -40 upstream of the GM-CSF transcription initiation site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GM5	GM5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	47	47	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	40	40	NUM	CD	NumType=Card	_	_	_	_
29	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 689
# text = Exogenous ETS1, but not ELF1, can transactivate GM-CSF, through the GM5 site, in a PMA/ionomycin dependent manner.
1	Exogenous	Exogenous	PROPN	NNP	Number=Sing	_	_	_	_
2	ETS1	Ets1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	ELF1	ELF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	GM5	GM5	PROPN	NNP	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	ionomycin	ionomycin	ADP	IN	_	_	_	_	_
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 690
# text = Other unidentified ETS-like factors present in Jurkat cells are also capable of binding GM5.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
3	ETS	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	like	like	SCONJ	IN	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	SCONJ	IN	_	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	GM5	GM5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 691
# text = Mutation of the core ETS binding site from -GGAA- to -GGAT- prevents the binding of ETS-like factors with the exception of ETS1.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	core	core	NOUN	NN	Number=Sing	_	_	_	_
5	ETS	Et	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	GGAA	GGAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	GGAT	Ggat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	ETS	Ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	like	like	SCONJ	IN	_	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 692
# text = The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	way	way	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	_
14	specific	specific	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	fully	fully	ADV	RB	_	_	_	_	_
18	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	ETS1	ETS1	NUM	CD	NumType=Card	_	_	_	_
29	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 693
# text = Together these data suggest that ETS1 may be involved in mediating the increased GM-CSF production associated with T cell activation.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	ETS1	Ets1	PROPN	NNP	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 694
# text = Document 003002240 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002240	003002240	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 695
# text = Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels.
1	Monoclonal	Monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
2	anti-endothelial	anti-endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
10	arteritis	arteritis	PROPN	NNPS	Number=Plur	_	_	_	_
11	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
16	vessels	vessel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 696
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 697
# text = To create monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis to evaluate their ability to activate human umbilical vein endothelial cells (HUVEC), and to characterize the mechanism of EC activation.
1	To	to	PART	TO	_	_	_	_	_
2	create	create	VERB	VB	VerbForm=Inf	_	_	_	_
3	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
4	anti-endothelial	anti-endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	mAECA	mAECa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
15	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
24	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 698
# text = METHODS: A panel of mAECA was generated from peripheral blood lymphocytes of a patient with Takayasu arteritis, using Epstein-Barr virus transformation.
1	METHODS	methods	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
18	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 699
# text = Activity against macrovascular EC (HUVEC) and microvascular EC (human bone marrow EC immortalized by SV40) antigens was detected by enzyme-linked immunosorbent assay.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	against	against	ADP	IN	_	_	_	_	_
3	macrovascular	macrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
4	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	microvascular	microvascular	ADJ	JJ	Degree=Pos	_	_	_	_
10	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
14	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
15	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
16	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	immunosorbent	immunosorbent	ADJ	JJ	Degree=Pos	_	_	_	_
27	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 700
# text = Inhibition studies were used to select the monoclonal antibodies (mAECA) which share the same EC epitope binding specificity as the total IgG-AECA from the Takayasu arteritis patient.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	select	select	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	EC	Ec	NOUN	NN	Number=Sing	_	_	_	_
18	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
24	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	AECA	AECA	PROPN	NNP	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
30	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	_
31	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 701
# text = The binding of the mAECA to human aortic EC was studied by immunohistochemistry.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mAECA	mAECa	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	human	human	VERB	VB	VerbForm=Inf	_	_	_	_
8	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 702
# text = The secretion levels of interleukin-6 (IL-6) and von Willebrand factor (vWF) were determined, to serve as markers for EC activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	von	von	PROPN	NNP	Number=Sing	_	_	_	_
15	Willebrand	Willebrand	PROPN	NNP	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	vWF	vWF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 703
# text = The activated EC were examined for the adherence of a monocytic cell line (U937), as well as for expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and E-selectin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 704
# text = In addition, nuclear extracts of the mAECA-treated EC were analyzed for the induction of translocation of nuclear factor kappaB (NF-kappaB), using a specific NF-kappaB oligoprobe in an electrophoretic mobility shift assay.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	oligoprobe	oligoprobe	AUX	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
39	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
40	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
41	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 705
# text = RESULTS: Six mAECA were selected, the mixture of which produced 100% inhibition of binding of the original IgG (from the patient with Takayasu arteritis) to HUVEC.
1	RESULTS	results	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Six	six	NUM	CD	NumType=Card	_	_	_	_
4	mAECA	maecan	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	selected	select	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	original	original	ADJ	JJ	Degree=Pos	_	_	_	_
21	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
28	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 706
# text = All mAECA possessed high activity against macrovascular EC, but none had significant antimicrovascular EC activity.
1	All	all	DET	DT	_	_	_	_	_
2	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	_
3	possessed	possess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	macrovascular	macrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	none	none	NOUN	NN	Number=Sing	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	antimicrovascular	antimicrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 707
# text = The mAECA, but not normal human IgG, had anti-human aortic EC activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IgG	Igg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
12	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
13	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 708
# text = Four of the 6 mAECA activated EC, manifested by increased IL-6 and vWF secretion.
1	Four	four	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	6	6	NUM	CD	NumType=Card	_	_	_	_
5	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	vWF	vwf	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 709
# text = The 4 mAECA induced EC expression of adhesion molecules and increased adhesion of U937 monocytic cells to EC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 710
# text = In addition, these mAECA stimulated the nuclear translocation of the NF-kappaB transcription factor.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
6	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 711
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 712
# text = Our findings suggest that AECA may directly stimulate EC in Takayasu arteritis through elevation of adhesion molecule expression associated with NF-kappaB activation and adhesion of monocytes, and may therefore play a pathogenic role in the development of the vasculopathy in Takayasu arteritis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	AECA	AECA	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	directly	directly	ADV	RB	_	_	_	_	_
8	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
12	arteritis	arteritis	ADV	RB	_	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	therefore	therefore	ADV	RB	_	_	_	_	_
33	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	development	development	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	vasculopathy	vasculopathy	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
45	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 713
# text = Document 003002246 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002246	003002246	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 714
# text = Coexpression of NF-kappa B/Rel and Sp1 transcription factors in human immunodeficiency virus 1-induced, dendritic cell-T-cell syncytia.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-T	-t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 715
# text = Productive infection of T cells with human immunodeficiency virus 1 (HIV-1) typically requires that the T cells be stimulated with antigens or mitogens.
1	Productive	Productive	ADJ	JJ	Degree=Pos	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	typically	typically	ADV	RB	_	_	_	_	_
17	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 716
# text = This requirement has been attributed to the activation of the transcription factor NF-kappa B, which synergizes with the constitutive transcription factor Sp1 to drive the HIV-1 promoter.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	synergizes	synergize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	drive	drive	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 717
# text = Recently, we have found that vigorous replication of HIV-1 takes place in nonactivated memory T cells after syncytium formation with dendritic cells (DCs).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	vigorous	vigorous	ADJ	JJ	Degree=Pos	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	takes	take	NOUN	NNS	Number=Plur	_	_	_	_
14	place	place	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	nonactivated	nonactivated	ADJ	JJ	Degree=Pos	_	_	_	_
17	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	syncytium	syncytium	NOUN	NN	Number=Sing	_	_	_	_
22	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 718
# text = These syncytia lack activated cells as determined by an absence of staining for Ki-67 cell cycle antigen.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	_
3	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	as	as	SCONJ	IN	_	_	_	_	_
7	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	SCONJ	IN	_	_	_	_	_
12	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	Ki	Ki	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-67	-67	NUM	CD	NumType=Card	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
18	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 719
# text = The expression and activity of NF-kappa B and Sp1 were, therefore, analyzed in isolated T cells and DCs from humans and mice.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 720
# text = We have used immunolabeling, Western blot analysis, and electrophoretic mobility shift and supershift assays.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	immunolabeling	immunolabeling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
13	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
16	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 721
# text = T cells lack active NF-kappa B but express Sp1 as expected.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
11	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 722
# text = DCs express high levels of all known NF-kappa B and Rel proteins, with activity residing primarily within RelB, p50, and p65.
1	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	_
2	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
3	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	with	with	SCONJ	IN	_	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	residing	reside	VERB	VBG	VerbForm=Ger	_	_	_	_
19	primarily	primarily	ADV	RB	_	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 723
# text = However, DCs lack Sp1, which may explain the failure of HIV-1 to replicate in purified DCs.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DCs	Dcs	PROPN	NNP	Number=Sing	_	_	_	_
4	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
5	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 724
# text = Coexpression of NF-kappa B and Sp1 occurs in the heterologous DC-T-cell syncytia that are induced by HIV-1.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
13	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 725
# text = Therefore, HIV-1-induced cell fusion brings together factors that upregulate virus transcription.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
9	brings	bring	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	together	together	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	upregulate	upregulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 726
# text = Since DCs and memory T cells frequently traffic together in situ, these unusual heterologous syncytia could develop in infected individuals and lead to chronic HIV-1 replication without ostensible immune stimulation.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	frequently	frequently	ADV	RB	_	_	_	_	_
8	traffic	traffic	NOUN	NN	Number=Sing	_	_	_	_
9	together	together	ADV	RB	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	situ	situ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	unusual	unusual	ADJ	JJ	Degree=Pos	_	_	_	_
15	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
16	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	infected	infected	ADJ	JJ	Degree=Pos	_	_	_	_
21	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	chronic	chronic	PROPN	NNP	Number=Sing	_	_	_	_
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
30	without	without	ADP	IN	_	_	_	_	_
31	ostensible	ostensible	ADJ	JJ	Degree=Pos	_	_	_	_
32	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 727
# text = Document 003002252 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002252	003002252	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 728
# text = Possible differences in the mechanism(s) of action of different glucocorticoid hormone compounds.
1	Possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	s	s	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
15	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 729
# text = Different glucocorticoid hormones (GCH) show differences in the intensity and in the kinetics of their immunomodulating activity.
1	Different	different	ADJ	JJ	Degree=Pos	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	GCH	GCH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	immunomodulating	immunomodulating	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 730
# text = The mechanism(s) of action of GCH is under investigation, but is has been noted that they exert immune activity via the genomic pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	action	action	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	GCH	GCH	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	under	under	ADP	IN	_	_	_	_	_
12	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
27	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 731
# text = We have studied the effects of prednisone (PDN), deflazacort (DFC), and dexamethasone (DXM) on the production of cytokines (IL-2, IL-6, TNF-alpha, IL-10) by peripheral T lymphocytes, and the effects on the inhibition of NF-kB DNA binding activity by activated Jurkat cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	prednisone	prednisone	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PDN	PDN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	deflazacort	deflazacort	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	DFC	DFC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	DXM	DXM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
46	T	t	PROPN	NNP	Number=Sing	_	_	_	_
47	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
52	on	on	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
59	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
60	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
61	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
62	by	by	ADP	IN	_	_	_	_	_
63	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
64	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
65	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
66	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 732
# text = The data obtained show that the three GCH molecules exert an immunosuppression on cytokine production by T lymphocytes and a strong decrease in the nuclear translocation of NF-kB in Jurkat cells; moreover, (a) not all the cytokines investigated were affected, and not with the same intensity, by the three GCH and (b) DXM inhibited the binding activity of NF-kB less than that of DFC and PDN.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	exert	exert	ADP	IN	Typo=Yes	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
22	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	;	;	PUNCT	,	_	_	_	_	_
35	moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	a	a	X	LS	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	all	all	DET	PDT	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
44	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	not	not	ADV	RB	_	_	_	_	_
50	with	with	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
53	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	three	three	NUM	CD	NumType=Card	_	_	_	_
58	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	b	b	X	LS	_	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	DXM	DXm	PRON	PRP	Case=Acc|Gender=Masc|Number=Sing|Person=3|PronType=Prs	_	_	_	_
64	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
67	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
68	of	of	ADP	IN	_	_	_	_	_
69	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
72	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
73	than	than	ADP	IN	_	_	_	_	_
74	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
75	of	of	ADP	IN	_	_	_	_	_
76	DFC	DFC	PROPN	NNP	Number=Sing	_	_	_	_
77	and	and	CCONJ	CC	_	_	_	_	_
78	PDN	PDN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 733
# text = These data are in agreement with the concept that different GCH compounds might differ in their binding and affinity properties, tissue-specific metabolism, and interaction with transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	concept	concept	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	ADV	WRB	PronType=Rel	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
12	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
13	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
14	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
20	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 734
# text = Document 003002253 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002253	003002253	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 735
# text = Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression.
1	Abnormal	abnormal	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
14	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
15	erythematosus	erythematosus	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 736
# text = Numerous cellular and biochemical abnormalities in immune regulation have been described in patients with systemic lupus erythematosus (SLE), including surface
1	Numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
5	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
16	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
17	erythematosus	erythematosus	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	SLE	Sle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 737
# text = Ag receptor-initiated signaling events and lymphokine production.
1	Ag	ag	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
6	events	event	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 738
# text = Because NF-kappa B contributes to the transcription of numerous inflammatory genes and has been shown to be a molecular target of antiinflammatory drugs, we sought to characterize the functional role of the NF-kappa B protein complex in lupus T cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	b	PROPN	NNP	Number=Sing	_	_	_	_
6	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	target	target	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
28	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
33	role	role	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	lupus	lupus	ADJ	JJ	Degree=Pos	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 739
# text = Freshly isolated T cells from lupus patients, rheumatoid arthritis (RA) patients, and normal individuals were activated physiologically via the TCR with anti-CD3 and anti-CD28
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	physiologically	physiologically	ADV	RB	_	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 740
# text = Abs to assess proximal membrane signaling, and with PMA and a calcium ionophore (A23187) to bypass membrane-mediated signaling events.
1	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
4	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
5	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
14	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	bypass	bypass	VERB	VB	VerbForm=Inf	_	_	_	_
20	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 741
# text = We measured the NF-kappa B binding activity in nuclear extracts by gel shift analysis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
15	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
16	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 742
# text = When compared with normal cells, the activation of NF-kappa B activity in SLE patients was significantly decreased in SLE, but not in RA, patients.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	SLE	SLE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 743
# text = NF-kappa B binding activity was absent in several SLE patients who were not receiving any medication, including corticosteroids.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	SLE	Sle	PROPN	NNP	Number=Sing	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	who	who	PRON	WP	PronType=Rel	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
17	any	any	DET	DT	_	_	_	_	_
18	medication	medication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	corticosteroids	corticosteroid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 744
# text = Also, NF-kappa B activity remained absent in follow-up studies.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	absent	absent	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	follow	follow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	up	up	NOUN	NN	Number=Sing	_	_	_	_
14	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 745
# text = In supershift experiments using specific Abs, we showed that, in the group of SLE patients who displayed undetectable NF-kappa B activity, p65 complexes were not formed.
1	In	in	ADP	IN	_	_	_	_	_
2	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	group	group	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	who	who	PRON	WP	PronType=Rel	_	_	_	_
19	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	p65	p65	NUM	CD	NumType=Card	_	_	_	_
28	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 746
# text = Finally, immunoblot analysis of nuclear extracts showed decreased or absent p65 protein levels.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	p65	p65	NUM	CD	NumType=Card	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 747
# text = As p65 complexes are transcriptionally active in comparison to the p50 homodimer, this novel finding may provide insight on the origin of abnormal cytokine or other gene transcription in SLE patients.
1	As	as	ADP	IN	_	_	_	_	_
2	p65	p65	NUM	CD	NumType=Card	_	_	_	_
3	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
12	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
16	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
19	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
32	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 748
# text = Document 003002268 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002268	003002268	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 749
# text = Apoptosis-resistant T cells have a deficiency in NF-kappaB-mediated induction of Fas ligand transcription.
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	kappaB-	kappaB-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 750
# text = Apoptosis induced through the TCR in CD4+ T cells is mostly mediated by the inducible expression of Fas ligand (FasL) as a primary event leading to the commitment to death.
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	T	t	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	mostly	mostly	ADV	RB	_	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Fas	Fas	PROPN	NNPS	Number=Plur	_	_	_	_
20	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	FasL	Fasl	INTJ	UH	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
27	event	event	NOUN	NN	Number=Sing	_	_	_	_
28	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 751
# text = To gain a better understanding of the transcriptional events that regulate this expression, we took advantage of our previously described mutant Jurkat cells.
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
5	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	took	take	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	described	describe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 752
# text = These cells are deficient in FasL expression and apoptosis induced upon TCR triggering, although their cytokine (IL-2 and IFN-gamma) production is normal.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
13	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	although	although	SCONJ	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 753
# text = Here we show that both a FasL- and a consensus NF-kappaB- reporter construct are inefficiently induced in these cells compared to wild-type cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	FasL	Fasl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	inefficiently	inefficiently	ADV	RB	_	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 754
# text = In addition, we demonstrate that the inducible transcriptional activity of the FasL reporter is abolished by specific inhibitors of NF-kappaB activation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 755
# text = Thus, we could trace the deficit of the mutant cells to an inefficient NF-kappaB activation, evidencing a relevant role for NF-kappaB in the regulation of FasL expression in activated T cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	trace	trace	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	deficit	deficit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inefficient	inefficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	evidencing	evidence	VERB	VBG	VerbForm=Ger	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 756
# text = Furthermore, our results suggest that the induction of FasL versus cytokine gene expression is differentially sensitive to NF-kappaB deprivation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FasL	Fasl	NOUN	NN	Number=Sing	_	_	_	_
11	versus	versus	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	differentially	differentially	ADV	RB	_	_	_	_	_
17	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 757
# text = Document 003002274 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002274	003002274	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 758
# text = cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.
1	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 759
# text = We demonstrate that JunD, a component of the AP-1 transcription factor complex, activates transcription of the human proenkephalin gene in a fashion that is completely dependent upon the cAMP-dependent protein kinase, protein kinase A.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	component	component	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	completely	completely	ADV	RB	_	_	_	_	_
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	upon	upon	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	A	A	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 760
# text = Activation of proenkephalin transcription by JunD is dependent upon a previously characterized cAMP-, phorbol ester-, and Ca(2+)-inducible enhancer, and JunD is shown to bind the enhancer as a homodimer.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Ca	Ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 761
# text = Another component of the AP-1 transcription complex, JunB, is shown to inhibit activation mediated by JunD.
1	Another	another	DET	DT	_	_	_	_	_
2	component	component	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 762
# text = As a homodimer JunB is unable to bind the enhancer; however in the presence of c-Fos, high-affinity binding is observed.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
4	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	however	however	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 763
# text = Furthermore, JunD is shown to activate transcription of genes linked to both cAMP and phorbol ester response elements in a protein kinase A-dependent fashion, further blurring the distinction between these response elements.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	further	further	SCONJ	IN	_	_	_	_	_
30	blurring	blurre	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	distinction	distinction	NOUN	NN	Number=Sing	_	_	_	_
33	between	between	ADP	IN	_	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 764
# text = These results demonstrate that the transcriptional activity of an AP-1-related protein is regulated by the cAMP-dependent second-messenger pathway and suggest that JunD and other AP-1-related proteins may play an important role in the regulation of gene expression by cAMP-dependent intracellular signaling pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
43	role	role	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
54	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
55	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
56	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 765
# text = Document 003002277 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002277	003002277	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 766
# text = Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 767
# text = We investigated the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and compared it with the basis of this induction by lipopolysaccharide (LPS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
56	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 768
# text = Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	or	or	CCONJ	CC	_	_	_	_	_
23	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	whereas	whereas	SCONJ	IN	_	_	_	_	_
29	only	only	ADV	RB	_	_	_	_	_
30	one	one	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
34	seemed	seem	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 769
# text = The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
4	concerned	concern	ADJ	JJ	Degree=Pos	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	1	1	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	73	73	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	;	;	PUNCT	,	_	_	_	_	_
31	2	2	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	element	element	NOUN	NN	Number=Sing	_	_	_	_
35	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	between	between	ADP	IN	_	_	_	_	_
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	181	181	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	73	73	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	which	which	PRON	WDT	PronType=Rel	_	_	_	_
44	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	response	response	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
57	negatively	negatively	ADV	RB	_	_	_	_	SpaceAfter=No
58	;	;	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	3	3	X	LS	_	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	_
62	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
63	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
64	element	element	NOUN	NN	Number=Sing	_	_	_	_
65	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
68	224	224	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	which	which	PRON	WDT	PronType=Rel	_	_	_	_
71	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
72	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
73	by	by	ADP	IN	_	_	_	_	_
74	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
77	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 770
# text = LPS signaling was found to involve NF kappa B activation by the p50/p65 heterodimers.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
7	NF	NF	ADP	RP	_	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 771
# text = Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha, in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
23	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	p65	p65	NUM	CD	NumType=Card	_	_	_	_
34	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
37	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
41	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
45	control	control	NOUN	NN	Number=Sing	_	_	_	_
46	element	element	NOUN	NN	Number=Sing	_	_	_	_
47	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	6	6	NUM	CD	NumType=Card	_	_	_	_
53	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 772
# text = This removal occurred by activation of the constitutive Sp1 factor, whose increased binding activity and phosphorylation were mediated by IFN-gamma.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
3	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 773
# text = Document 003002279 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002279	003002279	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 774
# text = Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation.
1	Preassociation	Preassociation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	STAT2	Stat2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
10	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 775
# text = A variety of cytokines and growth factors act through an induction of gene expression mediated by a family of latent transcription factors called STAT (signal transducers and activators of transcription) proteins.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
27	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 776
# text = Ligand-induced tyrosine phosphorylation of the STATs promotes their homodimer and heterodimer formation and subsequent nuclear translocation.
1	Ligand	Ligand	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	STATs	STATs	PROPN	NNPS	Number=Plur	_	_	_	_
9	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
14	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 777
# text = We demonstrate here that
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_

# sent_id = 778
# text = STAT protein heterocomplexes exist prior to cytokine treatment.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	heterocomplexes	heterocomplex	NOUN	NNS	Number=Plur	_	_	_	_
4	exist	exist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 779
# text = When unstimulated HeLa cells are ruptured in hypotonic buffer without salt or detergent, immunoadsorption of either STAT1 or STAT2 from the resulting cytosol yields coimmunoadsorption of the other STAT protein.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	unstimulated	unstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
3	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	ruptured	rupture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	hypotonic	hypotonic	ADJ	JJ	Degree=Pos	_	_	_	_
9	buffer	buffer	NOUN	NN	Number=Sing	_	_	_	_
10	without	without	ADP	IN	_	_	_	_	_
11	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	detergent	detergent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	immunoadsorption	immunoadsorption	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	either	either	CCONJ	CC	_	_	_	_	_
18	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	STAT2	STAT2	NUM	CD	NumType=Card	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
24	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
25	yields	yield	NOUN	NNS	Number=Plur	_	_	_	_
26	coimmunoadsorption	coimmunoadsorption	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 780
# text = Similarly, STAT1-STAT3 heterocomplexes are coimmunoadsorbed from hypotonic cytosol.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
6	heterocomplexes	heterocomplex	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	coimmunoadsorbed	coimmunoadsor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	hypotonic	hypotonic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 781
# text = STAT1 and STAT2 or STAT1 and STAT3 translated in reticulocyte lysate spontaneously form heterocomplexes when the translation lysates are mixed at 0 degrees C. Our data suggest that interferon-alpha /beta-induced tyrosine phosphorylation increases the stability of a preexisting, latent, STAT1-STAT2 signaling complex.
1	STAT1	STAT1	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	STAT2	STAT2	NOUN	NN	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	STAT1	STAT1	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
8	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
11	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
12	spontaneously	spontaneously	ADV	RB	_	_	_	_	_
13	form	form	ADJ	JJ	Degree=Pos	_	_	_	_
14	heterocomplexes	heterocomplex	NOUN	NNS	Number=Plur	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
18	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	0	0	NUM	CD	NumType=Card	_	_	_	_
23	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
24	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_
26	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
27	data	data	NOUN	NN	Number=Sing	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	/beta	/beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-induced	-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	preexisting	preexisting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	latent	latent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	STAT2	Stat2	NOUN	NN	Number=Sing	_	_	_	_
49	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
50	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 782
# text = Newly translated STAT1 binds in equilibrium fashion to STAT2 and STAT3, but we show that STAT2 and STAT3 exist in separate heterocomplexes with STAT1, consistent with a model in which STAT1 contains a common binding site for other STAT proteins.
1	Newly	newly	ADV	RB	_	_	_	_	_
2	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
4	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	equilibrium	equilibrium	ADJ	JJ	Degree=Pos	_	_	_	_
7	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	STAT2	Stat2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	STAT2	STAT2	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
20	exist	exist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
23	heterocomplexes	heterocomplex	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	model	model	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	_
34	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
37	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
38	site	site	NOUN	NN	Number=Sing	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
41	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
42	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 783
# text = Document 003002284 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002284	003002284	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 784
# text = The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	member	member	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	_
32	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 785
# text = Receptor activator of NF-kappaB (RANK) is a recently identified member of the tumor necrosis factor receptor superfamily and is expressed on activated T cells and dendritic cells.
1	Receptor	Receptor	NOUN	NN	Number=Sing	_	_	_	_
2	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
14	member	member	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	superfamily	superfamily	ADV	RB	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 786
# text = Its cognate ligand (RANKL) plays significant roles in the activation of dendritic cell function and osteoclast differentiation.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
3	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	RANKL	RANKL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
9	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	osteoclast	osteoclast	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 787
# text = We demonstrate here the interaction of RANK with tumor necrosis factor receptor-associated factors (TRAFs) 1, 2, 3, 5, and 6 both in vitro and in cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TRAFs	Trafs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	both	both	CCONJ	CC	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 788
# text = Mapping of the structural requirements for TRAF/RANK interaction revealed multiple TRAF binding sites clustered in two distinct domains in the RANK cytoplasmic tail.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
5	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	TRAF	TRAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	TRAF	Traf	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	clustered	cluster	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
24	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
25	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 789
# text = These TRAF binding domains were shown to be functionally important for the RANK-dependent induction of NF-kappaB and c-Jun NH2-terminal kinase activities.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	functionally	functionally	ADV	RB	_	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	RANK	Rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	c	care	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
25	NH2	NH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-terminal	-terminal	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 790
# text = Site-directed mutagenesis demonstrated that these TRAF binding sites exhibited selective binding for different TRAF proteins.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	mutagenesis	mutagenesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	exhibited	exhibite	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	TRAF	TRAF	PROPN	NNP	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 791
# text = In particular, TRAF6 interacted with membrane-proximal determinants distinct from those binding TRAFs 1, 2, 3, and 5.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TRAF6	Traf6	PROPN	NNP	Number=Sing	_	_	_	_
5	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
10	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
11	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	TRAFs	TRAFs	ADV	RB	_	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 792
# text = When this membrane-proximal TRAF6 interaction domain was deleted, RANK-mediated NF-kappaB signaling was completely inhibited while c-Jun NH2-terminal kinase activation was partially inhibited.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
6	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	RANK	Rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	completely	completely	ADV	RB	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	while	while	SCONJ	IN	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
25	NH2	NH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	partially	partially	ADV	RB	_	_	_	_	_
32	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 793
# text = An NH2-terminal truncation mutant of TRAF6 inhibited RANKL-mediated NF-kappaB activation, but failed to affect constitutive signaling induced by receptor overexpression, revealing a selective role for TRAF6 in ligand-induced activation events.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	RANKL	Rankl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	revealing	reveal	VERB	VBG	VerbForm=Ger	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	ligand	ligand	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 794
# text = Document 003002287 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002287	003002287	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 795
# text = The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	150	150	NUM	CD	NumType=Card	_	_	_	_
9	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
26	target	target	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	C	c	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 796
# text = Stimulation of T cells with antigen results in activation of several kinases, including protein kinase C (PKC), that may mediate the later induction of activation-related genes.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	C	C	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 797
# text = We have examined the potential role of PKC in induction of the interleukin 2 (IL-2) gene in T cells stimulated through the T cell receptor/CD3 complex.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	through	through	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	T	T	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	receptor/CD3	receptor/CD3	NUM	CD	NumType=Card	_	_	_	_
30	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 798
# text = We have previously shown that prolonged treatment of the untransformed T cell clone Ar-5 with phorbol esters results in downmodulation of the alpha and beta isozymes of PKC, and abrogates induction of IL-2 mRNA and protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	untransformed	untransformed	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
14	Ar	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
19	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	downmodulation	downmodulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	isozymes	isozyme	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 799
# text = Here we show that phorbol ester treatment also abolishes induction of chloramphenicol acetyltransferase activity in Ar-5 cells transfected with a plasmid containing the IL-2 promoter linked to this reporter gene.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
6	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
13	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Ar	ar	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
24	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 800
# text = The IL-2 promoter contains binding sites for nuclear factors including NFAT-1, Oct, NF-kappa B, and AP-1, which are all potentially sensitive to activation of PKC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	NFAT	Nfat	ADV	RB	_	_	_	_	SpaceAfter=No
14	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	all	all	ADV	RB	_	_	_	_	_
31	potentially	potentially	ADV	RB	_	_	_	_	_
32	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 801
# text = We show that induction of a trimer of the NFAT and Oct sites is not sensitive to phorbol ester treatment, and that mutations in the NF-kappa B site have no effect on inducibility of the IL-2 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
19	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 802
# text = In contrast, mutations in the AP-1 site located at -150 bp almost completely abrogate induction of the IL-2 promoter, and appearance of an inducible nuclear factor binding to this site is sensitive to PKC depletion.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	150	150	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	almost	almost	ADV	RB	_	_	_	_	_
17	completely	completely	ADV	RB	_	_	_	_	_
18	abrogate	abrogate	ADJ	JJ	Degree=Pos	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
42	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 803
# text = Moreover, cotransfections with c-fos and c-jun expression plasmids markedly enhance induction of the IL-2 promoter in minimally stimulated T cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cotransfections	cotransfection	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
12	markedly	markedly	ADV	RB	_	_	_	_	_
13	enhance	enhance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	minimally	minimally	ADV	RB	_	_	_	_	_
23	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 804
# text = Our results indicate that the AP-1 site at -150 bp represents a major, if not the only, site of PKC responsiveness in the IL-2 promoter.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	150	150	NUM	CD	NumType=Card	_	_	_	_
13	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
14	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	if	if	SCONJ	IN	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	only	only	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
26	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 805
# text = Document 003002289 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002289	003002289	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 806
# text = Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells.
1	Lipopolysaccharide	Lipopolysaccharide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 807
# text = Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	c	class	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 808
# text = Biosynthesis of tumor necrosis factor-alpha (TNF-alpha) is predominantly by cells of the monocytic lineage.
1	Biosynthesis	Biosynthesis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	predominantly	predominantly	ADV	RB	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 809
# text = This study examined the role of various cis-acting regulatory elements in the lipopolysaccharide (LPS) induction of the human TNF-alpha promoter in cells of monocytic lineage.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
8	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 810
# text = Functional analysis of monocytic THP-1 cells transfected with plasmids containing various lengths of TNF-alpha promoter localized enhancer elements in a region (-182 to -37 base pairs (bp)) that were required for optimal transcription of the TNF-alpha gene in response to LPS.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
12	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
14	lengths	length	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	alpha	alpha	ADV	RB	_	_	_	_	_
19	promoter	promoter	ADV	RBR	Degree=Cmp	_	_	_	_
20	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	(-182	(-182	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	37	37	NUM	CD	NumType=Card	_	_	_	_
30	base	base	NOUN	NN	Number=Sing	_	_	_	_
31	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	that	that	PRON	WDT	PronType=Rel	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	alpha	alpha	ADV	RB	_	_	_	_	_
47	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	response	response	NOUN	NN	Number=Sing	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 811
# text = Two regions were identified: region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	-182	-182	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	162	162	NUM	CD	NumType=Card	_	_	_	_
13	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	overlapping	overlapp	ADJ	JJ	Degree=Pos	_	_	_	_
18	Sp1/Egr	Sp1/Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	II	ii	NUM	CD	NumType=Card	_	_	_	_
26	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
27	119	119	NUM	CD	NumType=Card	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	88	88	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	kappaB3	kappaB3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 812
# text = In unstimulated THP-1, CRE-binding protein and, to a lesser extent, c-Jun complexes were found to bind to the CRE site.
1	In	in	ADP	IN	_	_	_	_	_
2	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
3	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
16	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
21	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	CRE	Cre	PROPN	NNP	Number=Sing	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 813
# text = LPS stimulation increased the binding of c-Jun-containing complexes.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 814
# text = In addition, LPS stimulation induced the binding of cognate nuclear factors to the Egr-1 and kappaB3 sites, which were identified as Egr-1 and p50/p65, respectively.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappaB3	kappaB3	NUM	CD	NumType=Card	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p50/	p50/	SYM	SYM	_	_	_	_	SpaceAfter=No
29	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 815
# text = The CRE and kappaB3 sites in region II together conferred strong LPS responsiveness to a heterologous promoter, whereas individually they failed to provide transcriptional activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	kappaB3	kappaB3	NOUN	NN	Number=Sing	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	together	together	ADV	RB	_	_	_	_	_
10	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
12	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
13	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	individually	individually	ADV	RB	_	_	_	_	_
21	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
22	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 816
# text = Furthermore, increasing the spacing between the CRE and the kappaB3 sites completely abolished LPS induction, suggesting a cooperative interaction between c-Jun complexes and p50/p65.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	spacing	spacing	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	kappaB3	kappaB3	NOUN	NN	Number=Sing	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
21	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
26	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
29	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 817
# text = These studies indicate that maximal LPS induction of the TNF-alpha promoter is mediated by concerted participation of at least two separate cis-acting regulatory elements.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
6	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	concerted	concert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	at	at	ADV	RB	_	_	_	_	_
21	least	least	ADV	RBS	Degree=Sup	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
24	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 818
# text = Document 003002291 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002291	003002291	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 819
# text = Synergism between the CD3 antigen- and CD2 antigen-derived signals.
1	Synergism	Synergism	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
5	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 820
# text = Exploration at the level of induction of DNA-binding proteins and characterization of the inhibitory activity of cyclosporine.
1	Exploration	exploration	NOUN	NN	Number=Sing	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	level	level	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 821
# text = We have demonstrated earlier that the crosslinkage of the CD3/TCR complex with the CD2 antigen results in the proliferation of normal human T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	crosslinkage	crosslinkage	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD3/TCR	Cd3/tcr	PROPN	NNP	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
15	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
16	results	result	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 822
# text = The effect of this synergism was perceptible at the level of induction of the IL-2 gene, a process critical for T cell growth.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	perceptible	perceptible	ADJ	JJ	Degree=Pos	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	level	level	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	process	process	NOUN	NN	Number=Sing	_	_	_	_
22	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 823
# text = To further understand the molecular and nuclear basis for this synergism, we have explored the induction of DNA-binding proteins in highly purified normal human T cells signaled via the CD3 and/or CD2 proteins.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	highly	highly	ADV	RB	_	_	_	_	_
25	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	signaled	signale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	via	via	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	or	or	CCONJ	CC	_	_	_	_	_
37	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 824
# text = The effect of transmembrane signaling of T cells with ionomycin, and/or sn-1,2 dioctanoyl glycerol, was also determined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	or	or	CCONJ	CC	_	_	_	_	_
15	sn	sn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,2	,2	NUM	CD	NumType=Card	_	_	_	_
19	dioctanoyl	dioctanoyl	NOUN	NN	Number=Sing	_	_	_	_
20	glycerol	glycerol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 825
# text = The emergence of nuclear binding proteins was investigated using interleukin-2 sequence specific oligonucleotide probes in the electrophoretic mobility shift assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
16	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 826
# text = Our studies demonstrate for the first time that CD3 antigen-derived signals and CD2 antigen-derived signals are synergistic in inducing the emergence of transcription factors that bind to the NF-AT1, AP-1, and NF-kB sites located in the promoter/enhancer region of the IL-2 gene.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	time	time	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	CD3	CD3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
16	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	AT1	AT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
45	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
46	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
51	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
52	region	region	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	2	2	NUM	CD	NumType=Card	_	_	_	_
58	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 827
# text = Moreover, cyclosporine, at concentrations readily accomplished in clinical practice, was found to inhibit the emergence of these DNA-binding proteins in normal human T cells signaled via cell surface proteins implicated in antigen-dependent
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
7	readily	readily	ADV	RB	_	_	_	_	_
8	accomplished	accomplish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
11	practice	practice	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	signaled	signale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	via	via	ADP	IN	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
35	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 828
# text = T cell activation and in T cells stimulated by mobilization of cellular calcium and activation of protein kinase C.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 829
# text = Document 003002298 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002298	003002298	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 830
# text = Monocytic cell type-specific transcriptional induction of collagenase.
1	Monocytic	Monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 831
# text = Interstitial collagenase (MMP-1), a metalloproteinase produced by resident and inflammatory cells during connective tissue turnover, cleaves type I collagen fibrils.
1	Interstitial	Interstitial	ADJ	JJ	Degree=Pos	_	_	_	_
2	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	MMP	Mmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
11	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	resident	resident	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	connective	connective	ADJ	JJ	Degree=Pos	_	_	_	_
19	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
20	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	cleaves	cleave	NOUN	NNS	Number=Plur	_	_	_	_
23	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	collagen	collagen	ADJ	JJ	Degree=Pos	_	_	_	_
26	fibrils	fibril	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 832
# text = This catalytic event is rate limiting in remodeling of tissues rich in fibrillar collagen such as the skin and lungs.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
6	limiting	limit	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	fibrillar	fibrillar	ADJ	JJ	Degree=Pos	_	_	_	_
14	collagen	collagen	NOUN	NNS	Number=Plur	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 833
# text = The regulation of collagenase expression is cell-type specific; bacterial LPS and zymosan, a yeast cell wall derivative, are potent inducers of collagenase expression in macrophages, but do not alter fibroblast collagenase expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
13	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	zymosan	zymosan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	yeast	yeast	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
21	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
36	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
37	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 834
# text = Since promoter elements controlling collagenase transcription in monocytic cells have not been previously defined, we sought to delineate responsive cis-acting elements of the collagenase promoter in transiently transfected human (U937) and murine (J774) monocytic cell lines.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
5	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
21	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	transiently	transiently	ADV	RB	_	_	_	_	_
31	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	human	human	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	J774	J774	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 835
# text = Deletion constructs containing as little as 72 bp of 5' -flanking sequence of the collagenase promoter were sufficient for LPS- or zymosan-mediated transcriptional induction, whereas phorbol inducibility exhibited an absolute requirement for upstream elements including the polyoma enhancer A-binding protein-3 site (-83 to -91) and TTCA sequence (-102 to -105) in both monocytic cells and fibroblasts.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
3	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	72	72	NUM	CD	NumType=Card	_	_	_	_
8	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	''	_	_	_	_	_
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	zymosan	zymosan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
33	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
34	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	absolute	absolute	ADJ	JJ	Degree=Pos	_	_	_	_
37	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
40	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
41	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	polyoma	polyoma	NOUN	NN	Number=Sing	_	_	_	_
44	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
45	A-	A-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
47	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-3	-3	NUM	CD	NumType=Card	_	_	_	_
49	site	site	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
52	83	83	NUM	CD	NumType=Card	_	_	_	_
53	to	to	ADP	IN	_	_	_	_	_
54	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
55	91	91	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	TTCA	Ttca	PROPN	NNP	Number=Sing	_	_	_	_
59	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
60	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
61	102	102	NUM	CD	NumType=Card	_	_	_	_
62	to	to	ADP	IN	_	_	_	_	_
63	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
64	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	in	in	ADP	IN	_	_	_	_	_
67	both	both	DET	DT	_	_	_	_	_
68	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
69	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 836
# text = Mutagenesis of the activator protein-1 [AP-1] site at -72 abolished basal promoter activity and LPS/zymosan inducibility, while mutagenesis of an NF-kappaB-like site at -20 to -10 had no effect.
1	Mutagenesis	Mutagenesis	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	]	]	PUNCT	-RRB-	_	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	72	72	NUM	CD	NumType=Card	_	_	_	_
17	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	zymosan	zymosan	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	20	20	NUM	CD	NumType=Card	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	10	10	NUM	CD	NumType=Card	_	_	_	_
43	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	no	no	DET	DT	_	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 837
# text = Nuclear extracts from LPS- and zymosan-treated cells showed strong AP-1 activity by gel-shift analysis, and supershift analysis showed the AP-1 complexes contained specific members of both the jun and fos gene families.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	zymosan	zymosan	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
21	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
25	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
26	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	members	member	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	both	both	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
41	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 838
# text = These data indicate that, in contrast to most LPS effects, AP-1, but not nuclear factor-kappaB, mediates LPS induction of collagenase transcription in macrophagelike cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
10	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	LPS	Lp	ADJ	JJ	Degree=Pos	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	macrophagelike	macrophagelike	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 839
# text = Furthermore, as compared to regulation by phorbol ester, collagenase induction in monocytic cells by cell wall derivatives of bacteria or yeast is largely independent of upstream promoter sequences.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
19	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	largely	largely	ADV	RB	_	_	_	_	_
26	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 840
# text = Document 003002307 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002307	003002307	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 841
# text = Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells.
1	Salicylates	Salicylate	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
3	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 842
# text = Binding of plasma Factor VII/VIIa to the tissue factor (TF) receptor initiates the coagulation protease cascades.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
4	Factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	VII	VII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	VIIa	VIIa	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
19	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
20	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 843
# text = TF expression by circulating monocytes is associated with thrombotic and inflammatory complications in a variety of diseases.
1	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	thrombotic	thrombotic	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	complications	complication	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 844
# text = Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide (LPS) is mediated by binding of c-Rel/p65 heterodimers to a kappa B site in the TF promoter.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	p65	p65	NUM	CD	NumType=Card	_	_	_	_
28	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 845
# text = Here, we report that a family of anti-inflammatory agents, known as the salicylates, inhibited LPS induction of TF activity and TF gene transcription in human monocytes and monocytic THP-1 cells at clinically relevant doses.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	salicylates	salicylate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	TF	TF	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	clinically	clinically	ADV	RB	_	_	_	_	_
38	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
39	doses	dos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 846
# text = Furthermore, sodium salicylate blocked the LPS-induced proteolytic degradation of I kappa B alpha, which prevented the nuclear translocation of c-Rel/p65 heterodimers.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	sodium	sodium	ADJ	JJ	Degree=Pos	_	_	_	_
4	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
5	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	B	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	p65	p65	NUM	CD	NumType=Card	_	_	_	_
29	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 847
# text = In contrast, two other nonsteroidal anti-inflammatory drugs, ibuprofen and indomethacin, did not inhibit LPS induction of the TF gene.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
6	nonsteroidal	nonsteroidal	ADJ	JJ	Degree=Pos	_	_	_	_
7	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	ibuprofen	ibuprofen	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	indomethacin	indomethacin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 848
# text = These results indicated that salicylates inhibited LPS induction of TF gene transcription in monocytic cells by preventing nuclear translocation of c-Rel/p65 heterodimers.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	salicylates	salicylate	PROPN	NNPS	Number=Plur	_	_	_	_
6	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	p65	p65	NUM	CD	NumType=Card	_	_	_	_
26	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 849
# text = The clinical benefits of salicylates in the treatment of several diseases, including atherosclerosis and rheumatoid arthritis, may be related to their ability to reduce monocyte gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	benefits	benefit	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	salicylates	salicylate	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	rheumatoid	rheumatoid	NOUN	NN	Number=Sing	_	_	_	_
17	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	reduce	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
27	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 850
# text = Document 003002314 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002314	003002314	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 851
# text = CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival.
1	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 852
# text = CD30 is a cell-surface receptor that can augment lymphocyte activation and survival through its ability to induce the transcription factor NF-kappaB.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
11	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 853
# text = CD30, however, has also been implicated in the induction of apoptotic cell death of lymphocytes.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	death	death	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 854
# text = Here we show that one of the effects of CD30 signal transduction is to render cells sensitive to apoptosis induced by the type 1 tumor necrosis factor receptor (TNFR1).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	render	render	VERB	VB	VerbForm=Inf	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TNFR1	TNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 855
# text = This sensitization is dependent on the TRAF-binding sites within the CD30 cytoplasmic domain.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sensitization	sensitization	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 856
# text = One of the proteins that binds to these sites is TRAF2, a signal transduction molecule that is also utilized by TNFR1 to mediate the activation of several downstream kinases and transcription factors.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
16	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	TNFR1	tNFR1	PROPN	NNP	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
29	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
30	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 857
# text = During CD30 signal transduction, we found that binding of TRAF2 to the cytoplasmic domain of CD30 results in the rapid depletion of TRAF2 and the associated protein TRAF1 by proteolysis.
1	During	during	ADP	IN	_	_	_	_	_
2	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TRAF2	Traf2	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
18	results	result	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
22	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	TRAF1	tRAF1	NUM	CD	NumType=Card	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 858
# text = These data suggest a model in which CD30 limits its own ability to transduce cell survival signals through signal-coupled depletion of TRAF2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
9	limits	limit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	coupled	coupl	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 859
# text = Depletion of intracellular TRAF2 and its coassociated proteins also increased the sensitivity of the cell to undergoing apoptosis during activation of death-inducing receptors such as TNFR1.
1	Depletion	Depletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	coassociated	coassociate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	undergoing	undergoing	ADJ	JJ	Degree=Pos	_	_	_	_
18	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	TNFR1	TNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 860
# text = Consistent with this hypothesis, expression of a dominant-negative form of TRAF2 was found to potentiate TNFR1-mediated death.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	form	form	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TRAF2	TRAF2	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	potentiate	potentiate	VERB	VB	VerbForm=Inf	_	_	_	_
19	TNFR1	tNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 861
# text = These studies provide a potential mechanism through which CD30, as well as other TRAF-binding members of the TNFR superfamily, can negatively regulate cell survival.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	well	well	ADV	RB	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	_
22	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	negatively	negatively	ADV	RB	_	_	_	_	_
26	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 862
# text = Document 003002320 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002320	003002320	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 863
# text = Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.
1	Calcineurin	Calcineurin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	inactivate	inactivate	VERB	VB	VerbForm=Inf	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B/	B/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	MAD3	MAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 864
# text = The interleukin-2 (IL-2) promoter consists of several independent T cell receptor (TcR) responsive elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 865
# text = The induction of promoters dependent on these elements is inhibitable by the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK-506).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	inhibitable	inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
14	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
15	A	A	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	tacrolimus	tacrolimus	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	FK	FK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	506	506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 866
# text = Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the FK-506- and CsA-sensitive enzyme required for TcR mediated activation of the IL-2 promoter.
1	Calcineurin	Calcineurin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	Ca2+/calmodulin	Ca2+/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	FK	FK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	506	506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 867
# text = We report that a constitutively active form of calcineurin partially substitutes for the Ca2+ co-stimulus required to activate the IL-2 promoter elements IL-2A (which binds the factors OAP and Oct-1) and IL-2E (which binds NF-AT), and completely substitutes for the Ca2+ co-stimulus required to stimulate an NF-kappa B-dependent element.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	constitutively	constitutively	ADV	RB	_	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
10	partially	partially	ADV	RB	_	_	_	_	_
11	substitutes	substitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	co-stimulus	co-stimulus	NOUN	NN	Number=Sing	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	A	a	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	OAP	OAP	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2E	2E	PROPN	NNP	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	which	which	PRON	WDT	PronType=Int	_	_	_	_
47	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	completely	completely	ADV	RB	_	_	_	_	_
55	substitutes	substitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
56	for	for	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	+	+	SYM	SYM	_	_	_	_	_
60	co-stimulus	co-stimulus	NOUN	NN	Number=Sing	_	_	_	_
61	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	to	to	PART	TO	_	_	_	_	_
63	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
64	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
65	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
68	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
71	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 868
# text = Calcineurin stimulates the NF-kappa B element by enhancing inactivation of I kappa B/MAD3, an inhibitor of NF-kappa B, thereby increasing the amount of nuclear NF-kappa B DNA binding activity.
1	Calcineurin	Calcineurin	PROPN	NNP	Number=Sing	_	_	_	_
2	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
11	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B/	B/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	MAD3	MAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	thereby	thereby	ADV	RB	_	_	_	_	_
27	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
37	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 869
# text = These data provide the first demonstration in vivo that activation of a protein phosphatase can inactivate I kappa B, and suggest one possible explanation for mechanism-based toxicities associated with FK-506 and CsA by demonstrating that these drugs can inhibit the calcineurin-dependent activation of a virtually ubiquitous transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	inactivate	inactivate	VERB	VB	VerbForm=Inf	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
23	one	one	NUM	CD	NumType=Card	_	_	_	_
24	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
25	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	toxicities	toxicity	NOUN	NNS	Number=Plur	_	_	_	_
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	FK	FK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	506	506	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
38	by	by	SCONJ	IN	_	_	_	_	_
39	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
43	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
44	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
49	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	virtually	virtually	ADV	RB	_	_	_	_	_
53	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 870
# text = Document 003002321 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002321	003002321	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 871
# text = Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	AIR	AIR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	during	during	ADP	IN	_	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 872
# text = In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
6	control	control	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 873
# text = Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription.
1	Class	class	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	_
3	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	because	because	ADP	IN	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
14	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
15	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	abrogation	abrogation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 874
# text = We show here that the plasma cell-specific repressor function, designated SIR (suppressor of immune response genes), does not act directly on the transcription of class II genes, but instead on the transcription of the AIR-1 gene, whose product, the class II transactivator (CIITA), is fundamental for the regulation of the constitutive and inducible expression of MHC class II genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	SIR	Sir	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
26	directly	directly	ADV	RB	_	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	class	class	NOUN	NN	Number=Sing	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	instead	instead	ADV	RB	_	_	_	_	_
37	on	on	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	AIR	Air	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
48	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	class	class	NOUN	NN	Number=Sing	_	_	_	_
52	II	ii	NUM	CD	NumType=Card	_	_	_	_
53	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
59	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
60	for	for	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
68	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
71	class	class	NOUN	NN	Number=Sing	_	_	_	_
72	II	ii	NUM	CD	NumType=Card	_	_	_	_
73	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
74	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 875
# text = This was unambiguously demonstrated by the fact that plasmacytoma x B cell hybrids carrying an AIR-1 locus derived from CIITA-expressing cells do not express CIITA-specific transcripts.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	unambiguously	unambiguously	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
10	x	x	SYM	SYM	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
14	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	AIR	AIR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
20	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	expressing	expresse	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
29	CIITA	CIITa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 876
# text = Transfection of a cDNA containing the human CIITA coding sequence under the control of an heterologous promoter restores expression of human MHC class II genes in the hybrids and is responsible for de novo expression of mouse MHC class II genes in both the mouse plasmacytoma cell line and the hybrids.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
9	coding	code	NOUN	NN	Number=Sing	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	under	under	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	restores	restore	NOUN	NNS	Number=Plur	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	de	de	PROPN	NNP	Number=Sing	_	_	_	_
34	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
38	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
39	class	class	NOUN	NN	Number=Sing	_	_	_	_
40	II	ii	NUM	CD	NumType=Card	_	_	_	_
41	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	both	both	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
46	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	line	line	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 877
# text = These results confirm and extend the notion of the functional conservation of the AIR-1 gene product across species barriers.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	extend	extend	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	conservation	conservation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AIR	Air	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	product	product	NOUN	NN	Number=Sing	_	_	_	_
19	across	across	ADP	IN	_	_	_	_	_
20	species	species	NOUN	NNS	Number=Plur	_	_	_	_
21	barriers	barrier	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 878
# text = Interestingly, in CIITA-transfected cell hybrids, cell surface expression of the human HLA-DQ heterodimer was not observed.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
19	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 879
# text = This result was not attributable to lack of HLA-DQ alpha or -DQ beta transcription, because both transcripts were present in the CIITA-transfected hybrids, although at reduced levels.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	DQ	Dq	ADJ	JJ	Degree=Pos	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	although	although	SCONJ	IN	_	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 880
# text = These findings further support our previous observations on the distinct regulation of expression of the human HLA-DQ class II subset, which may be thus controlled at the posttranscriptional level by a CIITA-independent mechanism.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
7	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	subset	subset	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	thus	thus	ADV	RB	_	_	_	_	_
28	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
38	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 881
# text = Document 003002324 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002324	003002324	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 882
# text = Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	supernatant	supernatant	ADJ	JJ	Degree=Pos	_	_	_	_
13	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 883
# text = T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune function and impaired activation of the transcription factor, NF-kappaB.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 884
# text = We determined the mechanism of NF-kappaB suppression in T cells of RCC patient and determined whether supernatant fluid from RCC explants (RCC-S) induced the same phenotype of NF-kappaB suppression in normal T cells that is observed in patient T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	RCC	Rcc	NOUN	NN	Number=Sing	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	whether	whether	SCONJ	IN	_	_	_	_	_
19	supernatant	supernatant	ADJ	JJ	Degree=Pos	_	_	_	_
20	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
23	explants	explant	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	S	s	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
32	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	that	that	PRON	WDT	PronType=Rel	_	_	_	_
43	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 885
# text = The pattern of kappaB-binding activity in T cells of RCC patient was altered as compared to that seen in T cells obtained from normal volunteers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
13	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	seen	see	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	volunteers	volunteer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 886
# text = In some patients, no activation of RelA/NFkappaB1-binding activity was detectable, while in others kappaB-binding activity was modestly induced but the duration was reduced.
1	In	in	ADP	IN	_	_	_	_	_
2	some	some	DET	DT	_	_	_	_	_
3	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	RelA/NFkappaB1	RelA/NFkappaB1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	others	other	NOUN	NNS	Number=Plur	_	_	_	_
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	modestly	modestly	ADV	RB	_	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 887
# text = IkappaBalpha was degraded normally following stimulation in both normal controls and T cells from RCC patients.
1	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	normally	normally	ADV	RB	_	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 888
# text = RCC-S did not alter the cytoplasmic levels of RelA and NF-kappaB1 but did suppress their nuclear localization and inhibited the activation of RelA/NF-kappaB1 binding complexes.
1	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	S	S	PROPN	NNP	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 889
# text = These results show that RCC-S can induce in normal T cells the same phenotype of impaired NF-kappaB activation that is detected in T cells of RCC patient.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	S	s	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	RCC	RCC	NOUN	NN	Number=Sing	_	_	_	_
31	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 890
# text = It also appears that NF-kappaB suppression by RCC-S may contribute to the immunosuppression of host immunity.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	S	s	PROPN	NNP	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	host	host	NOUN	NN	Number=Sing	_	_	_	_
20	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 891
# text = Document 003002325 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002325	003002325	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 892
# text = An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	isotype-specific	isotype-specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	class	class	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 893
# text = Patients with one type of major histocompatibility complex class II combined immunodeficiency have mutations in a gene termed class II transactivator (CIITA), which coordinately controls the transcription of the three major human class II genes, HLA-DR, -DQ, and -DP.
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	coordinately	coordinately	ADV	RB	_	_	_	_	_
28	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	three	three	NUM	CD	NumType=Card	_	_	_	_
34	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	class	class	NOUN	NN	Number=Sing	_	_	_	_
37	II	ii	NUM	CD	NumType=Card	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	DR	dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	DP	DP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 894
# text = However, the experimentally derived B-lymphoblastoid cell line, clone 13, expresses high levels of HLADQ in the absence of HLA-DR and HLA-DP, despite its mapping by complementation analysis to this group.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	experimentally	experimentally	ADV	RB	_	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
13	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HLADQ	HLADq	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	DP	DP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	despite	despite	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
37	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
40	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 895
# text = It was possible that one of the clone 13 CIITA alleles bore a mutation that allowed HLA-DQ, but not HLA-DR or -DP transcription.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
12	bore	bear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	ADV	RB	_	_	_	_	_
23	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	DP	Dp	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 896
# text = Alternatively, another factor, distinct from CIITA, might control HLA-DQ expression.
1	Alternatively	Alternatively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	another	another	DET	DT	_	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
11	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
12	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 897
# text = We report here that ectopic expression of CIITA cDNAs derived by reverse transcriptase polymerase chain reaction from clone 13 do not restore expression of HLA-DQ in another CIITA-deficient cell line, RJ2.2.5.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
9	cDNAs	cDNAs	NOUN	NNS	Number=Plur	_	_	_	_
10	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
13	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	_
14	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	_
20	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	another	another	DET	DT	_	_	_	_	_
30	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	RJ	RJ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	2.2.5	2.2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 898
# text = In addition, no CIITA protein is detectable in clone 13 nuclear extracts.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
11	13	13	NUM	CD	NumType=Card	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 899
# text = In contrast, somatic cell fusion between clone 13 and RJ2.2.5 restored expression of the HLA-DQ haplotype encoded by the RJ2.2.5 DQB gene.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RJ2.2.5	RJ2.2.5	NUM	CD	NumType=Card	_	_	_	_
12	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
19	haplotype	haplotype	NOUN	NN	Number=Sing	_	_	_	_
20	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	RJ2.2.5	RJ2.2.5	PROPN	NNP	Number=Sing	_	_	_	_
24	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
25	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 900
# text = Taken together, these data demonstrate the existence of an HLA-DQ isotype-specific trans-acting factor, which functions independently of CIITA.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
14	isotype-specific	isotype-specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	independently	independently	ADV	RB	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 901
# text = Document 003002328 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002328	003002328	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 902
# text = CIITA activates the expression of MHC class II genes in mouse T cells.
1	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 903
# text = It has long been a puzzle that MHC class II molecules are expressed in human T cells after activation but not in mouse T cells; this expression is believed to play a role in the cell mediated immune response.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	long	long	ADV	RB	Degree=Pos	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	puzzle	puzzle	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	role	role	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 904
# text = Recently the MHC class II transactivator (CIITA) has been reported to be a major regulatory factor for both the constitutive and IFN inducible expression of MHC class II genes.
1	Recently	recently	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
29	class	class	NOUN	NN	Number=Sing	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 905
# text = Here we show that human T cells expressing MHC class II have CIITA transcripts while MHC class II-negative human T cells and mouse T cells do not.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	II	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
14	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
17	class	class	NOUN	NN	Number=Sing	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	do	do	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 906
# text = The expression of MHC class II genes in mouse T cells can be reconstituted upon transfection with the human CIITA cDNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	upon	upon	ADP	IN	_	_	_	_	_
16	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
21	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 907
# text = These data indicate that the expression of CIITA explains the expression or lack of expression of MHC class II in human and mouse T cells respectively.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
9	explains	explain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 908
# text = Document 003002330 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002330	003002330	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 909
# text = Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
1	Silencing	Silencing	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
5	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	EKLF	Eklf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 910
# text = Globin genes are subject to tissue-specific and developmental stage-specific regulation.
1	Globin	Globin	ADJ	JJ	Degree=Pos	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
11	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 911
# text = A switch from human fetal (gamma)-to adult (beta)-globin expression occurs within erythroid precursor cells of the adult lineage.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	fetal	fetal	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	to	to	ADP	IN	_	_	_	_	_
11	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
26	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 912
# text = Previously we and others showed by targeted gene disruption that the zinc finger gene, erythroid Kruppel-like factor (EKLF), is required for expression of the beta-globin gene in mice, presumably through interaction with a high-affinity binding site in the proximal promoter.
1	Previously	previously	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	others	other	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
13	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	erythroid	erythroid	PROPN	NNP	Number=Sing	_	_	_	_
17	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	presumably	presumably	ADV	RB	_	_	_	_	_
39	through	through	ADP	IN	_	_	_	_	_
40	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	site	site	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
51	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 913
# text = To examine the role of EKLF in the developmental regulation of the human gamma-globin gene we interbred EKLF heterozygotes (+/-) with mice harboring a human beta-globin yeast artificial chromosome transgene.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	interbred	interbr	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
21	heterozygotes	heterozygote	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	+/-)	+/-)	SYM	NFP	_	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
26	harboring	harbor	VERB	VBG	VerbForm=Ger	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
32	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	_
33	artificial	artificial	ADJ	JJ	Degree=Pos	_	_	_	_
34	chromosome	chromosome	ADJ	JJ	Degree=Pos	_	_	_	_
35	transgene	transgene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 914
# text = We find that in the absence of EKLF, while human beta-globin expression is dramatically reduced, gamma-globin transcripts are elevated approximately 5-fold.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	while	while	SCONJ	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	dramatically	dramatically	ADV	RB	_	_	_	_	_
18	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
23	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	approximately	approximately	ADV	RB	_	_	_	_	_
27	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 915
# text = Impaired silencing of gamma-globin expression identifies EKLF as the first transcription factor participating quantitatively in the gamma-globin to beta-globin switch.
1	Impaired	Impaired	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	silencing	silencing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	identifies	identify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	participating	participate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	quantitatively	quantitatively	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
26	switch	switch	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 916
# text = Our findings are compatible with a competitive model of switching in which EKLF mediates an adult stage-specific interaction between the beta-globin gene promoter and the locus control region that excludes the gamma-globin gene.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
8	model	model	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
14	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
17	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	locus	locus	ADJ	JJ	Degree=Pos	_	_	_	_
31	control	control	NOUN	NN	Number=Sing	_	_	_	_
32	region	region	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	excludes	exclude	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 917
# text = Document 003002336 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002336	003002336	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 918
# text = Membrane-associated lymphotoxin on natural killer cells activates endothelial cells via an NF-kappaB-dependent pathway.
1	Membrane	membrane	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
7	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 919
# text = BACKGROUND:
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 920
# text = Inhibition of complement in small animal models of xenotransplantation has demonstrated graft infiltration with natural killer (NK) cells and monocytes associated with endothelial cell (EC) activation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
7	models	model	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	xenotransplantation	xenotransplantation	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	graft	graft	NOUN	NN	Number=Sing	_	_	_	_
13	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
16	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 921
# text = We have previously demonstrated that human NK cells activate porcine EC in vitro, which results in adhesion molecule expression and cytokine secretion.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	porcine	porcine	PRON	PRP	_	_	_	_	_
11	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	DET	WDT	PronType=Int	_	_	_	_
16	results	result	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 922
# text = In this study, we used the NK cell line NK92 to define the molecular and cellular basis of NK cell-mediated EC activation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	NK92	Nk92	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 923
# text = METHODS: EC were transfected with either reporter constructs containing the luciferase gene driven either by E-selectin or interleukin (IL)-8 promoters or a synthetic NF-kappaB-dependent promoter.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	either	either	DET	DT	_	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	either	either	CCONJ	CC	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	8	8	NUM	CD	NumType=Card	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 924
# text = In addition, a dominant-negative mutant tumor necrosis factor receptor
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 925
# text = I (TNFRI) expression vector was co-transfected in inhibition studies.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TNFRI	TNFRI	X	AFX	_	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 926
# text = Forty-eight hours after transfection, EC were stimulated with NK cells or NK cell membrane extracts for 7 hr and activation was measured by a luciferase assay.
1	Forty	Forty	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	eight	eight	NUM	CD	NumType=Card	_	_	_	_
4	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	7	7	NUM	CD	NumType=Card	_	_	_	_
21	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
29	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 927
# text = RESULTS: Co-culture of NK cells with transfected EC enhanced E-selectin, IL-8, and NF-kappaB-dependent promoter activity.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Co-culture	Co-culture	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 928
# text = NK cell membrane extracts retained the capacity to activate EC and induced nuclear translocation of NF-kappaB (p50 and p65).
1	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	retained	retain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	p50	p50	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 929
# text = Western blotting of NK cell and membrane extracts detected the presence of Lymphotoxin-alpha (LTalpha) but not tumor necrosis factor-alpha.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Lymphotoxin	Lymphotoxin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	LTalpha	LTalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	tumor	tumor	ADP	IN	_	_	_	_	_
22	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 930
# text = Furthermore, LTalpha was secreted in NK:EC co-cultures.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LTalpha	LTalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NK:EC	Nk:ec	PROPN	NNP	Number=Sing	_	_	_	_
8	co-cultures	co-culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 931
# text = Co-transfection with dominant-negative mutant TNFRI inhibited EC activation by NK cell membrane extracts and by NK cells by 80% and 47%, respectively.
1	Co-transfection	Co-transfection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	TNFRI	Tnfri	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
15	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	%	%	SYM	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 932
# text = The same pattern of inhibition was observed using anti-human LT sera.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
3	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
10	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
11	sera	sera	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 933
# text = CONCLUSIONS: Human NK cell membrane-bound LT signals across species via TNFRI, leading to NF-kappaB nuclear translocation and transcription of E-selectin and IL-8, which results in EC activation.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	across	across	ADP	IN	_	_	_	_	_
12	species	species	NOUN	NNS	Number=Plur	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	TNFRI	TNFRI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	DET	WDT	PronType=Int	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 934
# text = The discrepancy in the degree of inhibition by membrane extracts and NK cells with mutant TNFRI suggests that additional pathways are utilized by NK cells to activate EC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	discrepancy	discrepancy	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	membrane	membrane	ADJ	JJ	Degree=Pos	_	_	_	_
10	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
16	TNFRI	TNFRI	PROPN	NNP	Number=Sing	_	_	_	_
17	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
20	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 935
# text = Document 003002346 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002346	003002346	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 936
# text = NF-kappaB only partially mediates Epstein-Barr virus latent membrane protein 1 activation of B cells.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	partially	partially	ADV	RB	_	_	_	_	_
6	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
12	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 937
# text = The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is required for EBV-induced immortalization of human B cells and causes tumorigenic transformation of cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LMP1	LMP1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
30	tumorigenic	tumorigenic	ADJ	JJ	Degree=Pos	_	_	_	_
31	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 938
# text = LMP1 expression induces phenotypic changes resembling B cell activation, such as cell size increase and up-regulation of cell surface activation markers.
1	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
5	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
6	resembling	resembl	VERB	VBG	VerbForm=Ger	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	size	size	NOUN	NN	Number=Sing	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 939
# text = LMP1 contains two domains that activate the transcription factor NF-kappaB, one through interactions with TRAF proteins and the other with the TRADD protein.
1	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	TRAF	TRAF	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 940
# text = The purpose of the present study was to investigate the importance of NF-kappaB induction in the up-regulation of the B cell activation markers ICAM-1 and CD71 by LMP1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
28	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	CD71	CD71	PROPN	NNP	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 941
# text = This study shows that expression of LMP1 activates transcription from p50/p65- and c-Rel- responsive promoters, and that this activity can be completely inhibited by expression of a dominant inhibitory IkappaB mutant.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
8	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	p50/p65-	p50/p65-	PUNCT	:	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	completely	completely	ADV	RB	_	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
33	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
34	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
35	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 942
# text = ICAM-1 and CD71 are nevertheless up-regulated by LMP1 in primary B cells and cell lines expressing the dominant IkappaB.
1	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	CD71	Cd71	PROPN	NNP	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	nevertheless	nevertheless	ADV	RB	_	_	_	_	_
8	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 943
# text = Furthermore, LMP1-induced cell size increase of primary B cells was unaffected by IkappaB expression.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	size	size	NOUN	NN	Number=Sing	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 944
# text = It was concluded that even when LMP1 is unable to activate NF-kappaB, it is still capable of inducing certain characteristics of activated B cells, strongly suggesting that LMP1 can also activate cells independently of NF-kappaB.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	even	even	ADV	RB	_	_	_	_	_
6	when	when	ADV	WRB	PronType=Int	_	_	_	_
7	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	still	still	ADV	RB	_	_	_	_	_
19	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	SCONJ	IN	_	_	_	_	_
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
23	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	strongly	strongly	ADV	RB	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	independently	independently	ADV	RB	_	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 945
# text = Document 003002347 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002347	003002347	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 946
# text = Potent gene regulatory and antiproliferative activities of 20-methyl analogues of 1,25 dihydroxyvitamin D3.
1	Potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
6	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	methyl	methyl	NOUN	NN	Number=Sing	_	_	_	_
11	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	1,25	1,25	NUM	CD	NumType=Card	_	_	_	_
14	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
15	D3	D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 947
# text = The biological active form of vitamin D3, 1,25-dihydroxyvitamin D3 (VD), regulates cellular growth and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
4	form	form	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
7	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
12	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 948
# text = This provides the hormone with an interesting therapeutic potential.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	interesting	interesting	ADJ	JJ	Degree=Pos	_	_	_	_
8	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
9	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 949
# text = However, hypercalcemia is a side effect, which is caused by VD's classical action, the regulation of calcium homeostasis.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	hypercalcemia	hypercalcemia	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	side	side	NOUN	NN	Number=Sing	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	's	's	PART	POS	_	_	_	_	_
15	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
16	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
22	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 950
# text = This made the need for VD analogues with selectively increased cell regulatory properties.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	made	make	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	need	need	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	VD	Vd	ADJ	JJ	Degree=Pos	_	_	_	_
7	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 951
# text = Studies with 20-epi analogues pointed out the importance of the carbon-20 position and led to the development of 20-methyl derivatives of VD.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	epi	epi	NOUN	NN	Number=Sing	_	_	_	_
6	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	_
7	pointed	point	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	out	out	ADP	RP	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	carbon	carbon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	20	20	NUM	CD	NumType=Card	_	_	_	_
16	position	position	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	development	development	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	methyl	methyl	NOUN	NN	Number=Sing	_	_	_	_
26	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	VD	VD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 952
# text = In this report the biological properties of the compounds ZK161422 and ZK157202, which are 20-methyl- and 20-methyl-23-eneanalogues, respectively, have been analyzed in comparison with VD.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
6	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
10	ZK161422	Zk161422	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	ZK157202	Zk157202	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	methyl	methyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	20-methyl	20-methyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	23	23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-eneanalogues	-eneanalogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 953
# text = Both compounds show about 2-fold lower affinity to the VD receptor (VDR) than VD.
1	Both	both	DET	DT	_	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	about	about	ADP	IN	_	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
8	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	VD	V	PROPN	NNP	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 954
# text = However, compared to VD, their antiproliferative effect is up to 30-fold higher on human peripheral blood mononuclear cells and even up to 300-fold higher on human breast cancer MCF-7 cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	up	up	ADV	RB	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
16	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	even	even	ADV	RB	_	_	_	_	_
25	up	up	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	300	300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
30	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
34	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
35	MCF	Mcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	7	7	NUM	CD	NumType=Card	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 955
# text = Whereas the hypercalcemic effect for ZK157202 is also increased 10-fold, ZK161422 has the same calcium-mobilizing potency as VD.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	hypercalcemic	hypercalcemic	ADJ	JJ	Degree=Pos	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	ZK157202	ZK157202	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	ZK	ZK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	161422	161422	NUM	CD	NumType=Card	_	_	_	_
16	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mobilizing	mobilizing	NOUN	NN	Number=Sing	_	_	_	_
22	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 956
# text = Moreover, ZK161422, but not ZK157202, showed preference for gene activation from a promoter carrying a VD response element with a palindromic arrangement of two hexameric receptor binding sites spaced by 9 nucleotides (IP9) rather than for activation from a response element formed by a direct repeat spaced by 3 nucleotides (DR3).
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ZK	ZK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	161422	161422	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	ZK157202	ZK157202	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	preference	preference	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	VD	Vd	PROPN	NNP	Number=Sing	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
26	arrangement	arrangement	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	hexameric	hexameric	ADJ	JJ	Degree=Pos	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	spaced	space	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	9	9	NUM	CD	NumType=Card	_	_	_	_
36	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	IP9	IP9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	rather	rather	ADV	RB	_	_	_	_	_
41	than	than	ADP	IN	_	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	from	from	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	_
47	element	element	NOUN	NN	Number=Sing	_	_	_	_
48	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
52	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
53	spaced	space	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	by	by	ADP	IN	_	_	_	_	_
55	3	3	NUM	CD	NumType=Card	_	_	_	_
56	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 957
# text = This observation supports a model, in which promoter selectivity reflects the selectively increased antiproliferative effect of VD analogues.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	promoter	promoter	ADJ	JJR	Degree=Cmp	_	_	_	_
10	selectivity	selectivity	NOUN	NN	Number=Sing	_	_	_	_
11	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	selectively	selectively	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	VD	Vd	ADJ	JJ	Degree=Pos	_	_	_	_
19	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 958
# text = Document 003002355 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002355	003002355	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 959
# text = Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	bifunctional	bifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 960
# text = Interaction between protein kinase C (PKC)- and glucocorticoid receptor (GR)-mediated signaling is suggested by the ability of the PKC activating phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to inhibit GR-dependent transcription of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR).
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
27	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
29	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
30	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
38	GR	Gr	ADV	RB	_	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
45	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
46	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
47	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
52	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
53	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 961
# text = Here we report that this interference is cell specific, as TPA augmented dexamethasone-induced transcriptional activation of the MMTV LTR in several T cell lines but was inhibitory in NIH-3T3 fibroblasts.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	SCONJ	IN	_	_	_	_	_
12	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
13	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	NIH	NIH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	3T3	3T3	NUM	CD	NumType=Card	_	_	_	_
35	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 962
# text = TPA-GR synergism was determined to have occurred at the GR-responsive element (GRE) level by functional analysis of deletion mutants or synthetic GRE oligonucleotides driving chloramphenicol acetyl-transferase expression.
1	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
4	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	have	have	AUX	VB	VerbForm=Inf	_	_	_	_
9	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
22	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
25	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
28	GRE	Gre	NOUN	NN	Number=Sing	_	_	_	_
29	oligonucleotides	oligonucleotide	SCONJ	IN	_	_	_	_	_
30	driving	drive	VERB	VBG	VerbForm=Ger	_	_	_	_
31	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
32	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 963
# text = Synergism required an intact GR DNA-binding domain, whereas amino- or carboxyl-terminal domains were dispensable.
1	Synergism	Synergism	PROPN	NNP	Number=Sing	_	_	_	_
2	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
5	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whereas	whereas	SCONJ	IN	_	_	_	_	_
12	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 964
# text = The effect was abrogated by the PKC inhibitor staurosporine, suggesting a role for PKC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 965
# text = Increased c-jun, jun-B, and jun-D expression above basal levels and increased transcriptional activity of AP-1/TPA responsive elements fused to chloramphenicol acetyl-transferase vectors were observed in T cells treated with TPA alone or in combination with dexamethasone.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-D	-d	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	above	above	ADP	IN	_	_	_	_	_
13	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	_
25	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
26	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
27	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	chloramphenicol	chloramphenicol	VERB	VB	VerbForm=Inf	_	_	_	_
30	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
33	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
42	alone	alone	ADV	RB	_	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 966
# text = The ability of Jun proteins to cooperate with GR in T cells has been investigated after transfection of c-jun, jun-B, or jun-D expression vectors, which augmented GR-dependent transcription from either MMTV LTR or GRE.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	D	d	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	GR	GR	ADV	RB	_	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	either	either	CCONJ	CC	_	_	_	_	_
40	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
41	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 967
# text = Conversely, c-jun and jun-B transfection blunted GR-dependent transcription in HeLa cells.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
8	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
9	blunted	blunt	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	GR	GR	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 968
# text = The presence of c-fos had a negative influence on GR function and correlated with the cell-specific synergistic or antagonistic activity of Jun with respect to GR; high basal expression of c-fos as well as AP-1 DNA binding and transcriptional activity were observed in HeLa cells, but not in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
33	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
39	as	as	ADV	RB	_	_	_	_	_
40	well	well	ADV	RB	Degree=Pos	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
50	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	but	but	CCONJ	CC	_	_	_	_	_
57	not	not	ADV	RB	_	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	T	t	PROPN	NNP	Number=Sing	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 969
# text = Furthermore overexpression of exogenous c-fos has an inhibitory effect on GR-dependent transcription from GRE in T cells.
1	Furthermore	furthermore	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 970
# text = We propose that Jun plays a bifunctional role on GR-dependent transcriptional activation of GRE, selecting either synergistic or antagonistic activity depending on the cell-specific microenvironment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
5	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	bifunctional	bifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	selecting	selecte	VERB	VBG	VerbForm=Ger	_	_	_	_
19	either	either	CCONJ	CC	_	_	_	_	_
20	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 971
# text = In this regard, intracellular levels of c-fos appear to be influential.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	influential	influential	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 972
# text = Document 003002357 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002357	003002357	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 973
# text = Cupric ion blocks NF kappa B activation through inhibiting the signal-induced phosphorylation of I kappa B alpha.
1	Cupric	Cupric	ADJ	JJ	Degree=Pos	_	_	_	_
2	ion	ion	NOUN	NN	Number=Sing	_	_	_	_
3	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	through	through	SCONJ	IN	_	_	_	_	_
9	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 974
# text = A transcription factor NF kappa B, which regulates expression of various cellular genes involved in immune responses and viral genes including HIV, is sequestered in the cytoplasm as a complex with an inhibitory protein I kappa B.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 975
# text = Various extracellular signals induce phosphorylation and rapid degradation of I kappa B alpha to release NF kappa B. Cu2+ was found to inhibit the activation of NF kappa B induced by TNF-alpha, TPA, or H2O2.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
4	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
8	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
19	Cu2	cu2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	TPA	Tpa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 976
# text = Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from I kappa B alpha, indicating that Cu2+ interferes with the dissociation of the NF kappa B-I kappa B complex.
1	Deoxycholate	Deoxycholate	ADJ	JJ	Degree=Pos	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
6	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
7	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Cu2	Cu2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	B	PROPN	NNP	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	I	I	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	B	PROPN	NNP	Number=Sing	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	Cu2	cu2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	+	+	SYM	SYM	_	_	_	_	_
39	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
46	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
47	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
49	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
50	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
51	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
52	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 977
# text = Neither phosphorylation nor degradation of I kappa B alpha was observed upon TNF-alpha stimulation in the presence of Cu2+.
1	Neither	neither	DET	DT	_	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	nor	nor	CCONJ	CC	_	_	_	_	_
4	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	upon	upon	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Cu2	Cu2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	+.	+.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 978
# text = These results indicate that Cu2+ inhibits the release of NF kappa B by blockade of a signal leading to the phosphorylation of I kappa B alpha.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Cu2	Cu2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	release	release	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	B	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 979
# text = Document 003002358 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002358	003002358	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 980
# text = Vitamin D3- and retinoic acid-induced monocytic differentiation: interactions between the endogenous vitamin D3 receptor, retinoic acid receptors, and retinoid X receptors in U-937 cells.
1	Vitamin	Vitamin	PROPN	NNP	Number=Sing	_	_	_	_
2	D3	D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
6	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
17	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	X	x	ADP	IN	_	_	_	_	_
27	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	937	937	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 981
# text = Retinoic acid (RA) and 1,25 alpha-dihydroxycholecalciferol (VitD3) are potent regulators of hematopoletic differentiation.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	_
8	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	dihydroxycholecalciferol	dihydroxycholecalciferol	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	hematopoletic	hematopoletic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 982
# text = Yet, little is known as to how the RA and VitD3 receptor network operates in hematopoietic cells, and whether receptor interactions can explain the interplay between the RA- and VitD3-signaling pathways during differentiation.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	to	to	SCONJ	IN	_	_	_	_	_
8	how	how	ADV	WRB	PronType=Int	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	network	network	NOUN	NN	Number=Sing	_	_	_	_
15	operates	operate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	whether	whether	SCONJ	IN	_	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
28	between	between	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-signaling	-signal	ADJ	JJ	Degree=Pos	_	_	_	_
35	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
36	during	during	ADP	IN	_	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 983
# text = Therefore, we analyzed the expression, DNA binding, and transcriptional activity of the endogenous RA and VitD3 receptors [retinoic acid receptors (RARs), retinoid X receptors (RXRs), and VitD3 receptor (VDR)] in the U-937 cell line, in which RA and VitD3 induce distinct monocytic differentiation pathways.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	VitD3	VitD3	NOUN	NN	Number=Sing	_	_	_	_
20	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
23	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
24	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	retinoid	retinoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
30	X	x	SYM	SYM	_	_	_	_	_
31	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	RXRs	RXR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	]	]	PUNCT	-RRB-	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	937	937	NUM	CD	NumType=Card	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	which	which	PRON	WDT	PronType=Rel	_	_	_	_
53	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
56	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
57	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
58	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
59	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
60	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 984
# text = VitD3 induction resulted in the formation of VDR/RXR DNA-binding complexes on both VitD3 response elements and RA response elements (RAREs).
1	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	VDR/RXR	VDR/RXR	PROPN	NNP	Number=Sing	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	RAREs	RARE	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 985
# text = However, transcriptional activation was only observed from a VitD3 response element-driven reporter construct.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 986
# text = Several DNA-binding complexes were detected on RAREs in undifferentiated cells.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	RAREs	RARE	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 987
# text = Stimulation by RA resulted in increased RAR beta/RXR DNA binding, activated RARE-dependent transcription, and increased expression of RAR-beta.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
8	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
11	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	RARE	rare	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 988
# text = Concomitant stimulation by VitD3 inhibited the RA-stimulated formation of RAR beta/RXR heterodimers, favoring VDR/RXR binding to the RARE.
1	Concomitant	Concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
5	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
13	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	favoring	favor	VERB	VBG	VerbForm=Ger	_	_	_	_
19	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	RARE	rare	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 989
# text = Also, VitD3 inhibited the expression of CD23 and CD49f, characteristic markers of retinoid-induced U-937 cell differentiation.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
4	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CD49f	CD49f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
13	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	937	937	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 990
# text = In contrast, neither the RA-stimulated, RARE-mediated transcription nor the induced RAR-beta expression was suppressed by VitD3, suggesting that VitD3 selectively inhibited the retinoid-induced differentiation program but not the RARE-mediated signal.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	neither	neither	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	RARE	rare	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	nor	nor	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
29	selectively	selectively	ADV	RB	_	_	_	_	_
30	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
36	program	program	NOUN	NN	Number=Sing	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	RARE	rare	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 991
# text = These results demonstrate a complex role for VitD3 in modifying the retinoid differentiation pathway and may have implications for differentiation-inducing therapy of hematopoietic tumors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	modifying	modify	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
18	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
26	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 992
# text = Document 003002360 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002360	003002360	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 993
# text = Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation, IL-2 production and stress-activated protein kinases in the murine T cell line EL4.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	EL4	El4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 994
# text = The association and activation of the IL-1 receptor-associated protein kinase (IRAK) to the IL-1 receptor complex is one of the earliest events detectable in IL-1 signal transduction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	association	association	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	one	one	NUM	CD	NumType=Card	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
30	events	event	NOUN	NNS	Number=Plur	_	_	_	_
31	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
37	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 995
# text = We generated permanent clones of the murine T cell line EL4 6.1 overexpressing human (h)IRAK to evaluate the role of this kinase in IL-1 signaling.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	EL4	EL4	NUM	CD	NumType=Card	_	_	_	_
12	6.1	6.1	NUM	CD	NumType=Card	_	_	_	_
13	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 996
# text = Overexpression of hIRAK enhanced IL-1-stimulated activation of the transcription factor NFkappaB, whereas a truncated form (N-IRAK) specifically inhibited IL-1-dependent NFkappaB activity.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	hIRAK	hIRAK	PROPN	NNP	Number=Sing	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	form	form	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	specifically	specifically	ADV	RB	_	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
33	NFkappaB	Nfkappab	ADJ	JJ	Degree=Pos	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 997
# text = In clones stably overexpressing hIRAK a weak constitutive activation of NFkappaB correlated with a low basal IL-2 production which was enhanced in an IL-1-dependent manner.
1	In	in	ADP	IN	_	_	_	_	_
2	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
5	hIRAK	hIRAK	PROPN	NNP	Number=Sing	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
16	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 998
# text = Compared to the parental cell line the dose-response curve of IL-1-induced IL-2 production was shifted in both potency and efficacy.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	curve	curve	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	shifted	shift	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 999
# text = These results demonstrate that IRAK directly triggers NFkappaB-mediated gene expression in EL4 cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	triggers	trigger	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EL4	EL4	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1000
# text = Qualitatively different effects were observed for the IL-1-induced activation of stress-activated protein (SAP) kinases: permanent overexpression of IRAK did not affect the dose dependence but prolonged the kinetics of IL-1-induced activation of SAP kinases, suggesting that this signaling branch may be regulated by distinct mechanisms.
1	Qualitatively	Qualitatively	ADV	RB	_	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	SAP	sap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
25	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
33	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	prolonged	prolong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	SAP	sap	NOUN	NN	Number=Sing	_	_	_	_
47	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
50	that	that	SCONJ	IN	_	_	_	_	_
51	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
52	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
53	branch	branch	NOUN	NN	Number=Sing	_	_	_	_
54	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
55	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
56	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
59	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1001
# text = Document 003002362 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002362	003002362	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1002
# text = Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	p105	p105	NUM	CD	NumType=Card	_	_	_	_
4	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transiently	transiently	ADV	RB	_	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1003
# text = Regulation of the transcription factor NF-kappaB involves proteasome-mediated processing of the NF-kappaB1 p105 precursor protein, which generates the p50 subunit of NF-kappaB.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	proteasome	proteasome	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
19	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
20	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
27	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1004
# text = The processing of p105 occurs constitutively in vivo but can be markedly enhanced by various cellular activation agents, although the underlying regulatory mechanism is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p105	p105	NUM	CD	NumType=Card	_	_	_	_
5	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
6	constitutively	constitutively	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	markedly	markedly	ADV	RB	_	_	_	_	_
13	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	although	although	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	yet	yet	ADV	RB	_	_	_	_	_
28	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1005
# text = In the present study, we demonstrate that signal-mediated induction of p105 processing in human T cells is associated with de novo synthesis of this precursor protein.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p105	p105	NUM	CD	NumType=Card	_	_	_	_
15	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	de	de	NOUN	NN	Number=Sing	_	_	_	_
24	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1006
# text = Transient transfection studies performed in COS7 cells revealed that the newly synthesized p105 protein appears to be more rapidly processed compared to its accumulated form that is already associated with the processed product p50.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	COS7	COS7	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	newly	newly	ADV	RB	_	_	_	_	_
12	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	p105	p105	NUM	CD	NumType=Card	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	more	more	ADV	RBR	_	_	_	_	_
19	rapidly	rapidly	ADV	RB	_	_	_	_	_
20	processed	process	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	form	form	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	already	already	ADV	RB	_	_	_	_	_
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	processed	process	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	product	product	NOUN	NN	Number=Sing	_	_	_	_
34	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1007
# text = Interestingly, the processing rate of p105 is markedly inhibited in cells co-transfected with p50 or other NF-kappaB subunits, including RelA and c-Rel, that physically interact with p105.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	markedly	markedly	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	physically	physically	ADV	RB	_	_	_	_	_
32	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1008
# text = These findings suggest that the processing of p105 is subject to negative regulation by the various NF-kappaB subunits.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
20	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1009
# text = We further demonstrate that p105 undergoes degradation in lipopolysaccharide-stimulated human monocytic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	p105	p105	NUM	CD	NumType=Card	_	_	_	_
6	undergoes	undergo	NOUN	NNS	Number=Plur	_	_	_	_
7	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1010
# text = However, the inducible degradation of p105 is not coupled with the generation of p50.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p105	p105	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1011
# text = Together, these studies demonstrate that the processing and inducible degradation of p105 are differentially regulated.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	differentially	differentially	ADV	RB	_	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1012
# text = Document 003002363 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002363	003002363	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1013
# text = The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	-tetradecanoylphorbol	-tetradecanoylphorbol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-13-acetate	-13-acetate	NOUN	NN	Number=Sing	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1014
# text = Terminal differentiation of the leukemic cell lines U-937 and HL-60 by 12-O-tetradecanoylphorbol-13-acetate is accompanied by marked changes in gene expression.
1	Terminal	Terminal	NOUN	NN	Number=Sing	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	U-	U-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-13-acetate	-13-acetate	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1015
# text = In this study, we demonstrate that the expression of jun and fos gene family members is induced with variable kinetics during 12-O-tetradecanoylphorbol-13-acetate induced differentiation, with c-jun expression best paralleling differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	members	member	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
21	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-acetate	-acetate	ADJ	JJ	Degree=Pos	_	_	_	_
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
34	paralleling	paralleling	NOUN	NN	Number=Sing	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1016
# text = The generation of AP-1 complexes, as measured by DNA binding activity, closely parallels morphological differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	closely	closely	ADV	RB	_	_	_	_	_
17	parallels	parallel	NOUN	NNS	Number=Plur	_	_	_	_
18	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1017
# text = Furthermore, the ability of these complexes to regulate gene expression is demonstrated by increased transcription from an AP-1 driven reporter construct and marked increases in the expression of endogenous AP-1 regulated genes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1018
# text = Differentiation assays using water soluble phorbol esters reveal that differentiation becomes irreversible soon after AP-1 appears.
1	Differentiation	Differentiation	NOUN	NN	Number=Sing	_	_	_	_
2	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	water	water	NOUN	NN	Number=Sing	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
7	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
8	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	irreversible	irreversible	ADJ	JJ	Degree=Pos	_	_	_	_
13	soon	soon	ADV	RB	Degree=Pos	_	_	_	_
14	after	after	SCONJ	IN	_	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1019
# text = This tight correlation between c-jun expression, the generation of AP-1 activity, and differentiation suggests a critical role for this gene and transcriptional complex during this process.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1020
# text = Document 003002364 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002364	003002364	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1021
# text = p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes.
1	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	_
2	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	phosphatidyl	phosphatidyl	VERB	VB	VerbForm=Inf	_	_	_	_
9	inositol	inositol	INTJ	UH	_	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
17	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1022
# text = p21ras is activated by the T cell antigen receptor (TCR) and then co-ordinates important signaling pathways for T lymphocyte activation.
1	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	then	then	ADV	RB	PronType=Dem	_	_	_	_
15	co-ordinates	co-ordinate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1023
# text = Effector pathways for this guanine nucleotide binding protein in T cells are mediated by the serine/threonine kinase Raf-1 and the Ras-related GTPase Rac-1.
1	Effector	Effector	NOUN	NN	Number=Sing	_	_	_	_
2	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
6	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Ras-	ras-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	related	relate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	GTPase	GTPase	PROPN	NNP	Number=Sing	_	_	_	_
28	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1024
# text = In fibroblasts, an important effector for the Ras oncogene is Phosphatidylinositol 3-kinase (PtdIns 3-kinase).
1	In	in	ADP	IN	_	_	_	_	_
2	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
10	oncogene	oncogene	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	Phosphatidylinositol	Phosphatidylinositol	PROPN	NNP	Number=Sing	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1025
# text = Activation of this lipid kinase is able to induce critical Rac-1 signaling pathways and can couple p21ras to cell survival mechanisms via the serine/threonine kinase Akt/PKB.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	lipid	lipid	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
11	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	couple	couple	VERB	VB	VerbForm=Inf	_	_	_	_
19	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
22	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1026
# text = The role of PtdIns 3-kinase in Ras signaling in T cells has not been explored.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
10	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1027
# text = In the present study, we examined the ability of PtdIns 3-kinase to initiate the Rac-1 signaling pathways important for T cell activation.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
22	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
23	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1028
# text = We also examined the possibility that Akt/PKB is regulated by Ras signaling pathways in T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Ras	Ras	SCONJ	IN	_	_	_	_	_
14	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
15	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1029
# text = The results show that Ras can initiate a Rac-1 mediated pathway that regulates the transcriptional function of AP-1 complexes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1030
# text = PtdIns 3-kinase signals cannot mimic p21ras and induce the Rac mediated responses of AP-1 transcriptional activation.
1	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
7	not	not	PART	RB	_	_	_	_	_
8	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
9	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Rac	Rac	PROPN	NNP	Number=Sing	_	_	_	_
14	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1031
# text = Moreover, neither TCR or Ras activation of AP-1 is dependent on PtdIns 3-kinase.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	neither	neither	CCONJ	CC	_	_	_	_	_
4	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-kinase	-kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1032
# text = PKB is activated in response to triggering of the T cell antigen receptor; PtdIns 3-kinase activity is both required and sufficient for this TCR response.
1	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	SCONJ	IN	_	_	_	_	_
7	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	PtdIns	PtdIns	NOUN	NNS	Number=Plur	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	both	both	ADV	RB	_	_	_	_	_
22	required	required	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1033
# text = In contrast, p21ras signals are unable to induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	p21ras	p21ras	NOUN	NN	Number=Sing	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
17	nor	nor	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
20	function	function	NOUN	NN	Number=Sing	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1034
# text = The present data thus highlight that PtdIns 3-kinase and Akt/PKB are not universal Ras effector molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	thus	thus	ADV	RB	_	_	_	_	_
5	highlight	highlight	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Akt	Akt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	universal	universal	ADJ	JJ	Degree=Pos	_	_	_	_
18	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
19	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
20	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1035
# text = Ras can initiate Rac-1 regulated signaling pathways in the context of T cell antigen receptor function independently of PtdIns 3-kinase activity.
1	Ras	Ra	NOUN	NNS	Number=Plur	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
4	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	context	context	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
16	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	independently	independently	ADV	RB	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1036
# text = Document 003002368 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002368	003002368	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1037
# text = Calcineurin activates transcription from the GM-CSF promoter in synergy with either protein kinase C or NF-kappa B/AP-1 in T cells.
1	Calcineurin	Calcineurin	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	PROPN	NNP	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/AP	/ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1038
# text = Two cis-acting elements GM-kappa B/GC-box and CLE0, of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene are required for maximal induction in Jurkat T cells by costimulation with phorbol-12-myristate acetate (PMA) and Ca2+ ionophore (A23187).
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B/GC	B/gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	gene	gene	PRON	NN	Number=Sing	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
47	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	+	+	SYM	SYM	_	_	_	_	_
54	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1039
# text = The GM-kappa B sequence is recognized by NF-kappa B, which is mainly induced by PMA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	gm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mainly	mainly	ADV	RB	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1040
# text = The CLE0 sequence interacts with factors, related to a PMA-induced AP-1 and a PMA/A23187-induced NF-AT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	PMA/A23187	PMA/A23187	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1041
# text = We examined whether signal transducing components in T cells can activate transcription of the GM-CSF gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
6	components	component	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1042
# text = Cotransfection of NF-kappa B (p50/p65)- or AP-1 (c-Jun/c-Fos)- expression vectors into Jurkat cells with a luciferase reporter containing the GM-CSF promoter did not stimulate transcription from the GM-CSF promoter.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)-	)-	PUNCT	.	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	Jun/c	Jun/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	:	_	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
30	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
31	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1043
# text = In contrast, cotransfection with a combination of NF-kappa B and AP-1 significantly augmented transcription from the GM-CSF promoter containing the GM-kappa B/GC-box and the CLE0 (AP-1/NF-AT).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B/GC	B/gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	box	box	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1/NF	1/nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	AT	At	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1044
# text = Expression of a constitutively active calcineurin (CN), a Ca2+/calmodulin-dependent protein phosphatase, potentiated by two fold the transcriptional activation by NF-kappa B/AP-1.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CN	CN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Ca2+/calmodulin	Ca2+/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1045
# text = Both constitutively active forms of CN and protein kinase C (PKC) synergistically activated transcription from the GM-CSF promoter.
1	Both	both	DET	DT	_	_	_	_	_
2	constitutively	constitutively	ADV	RB	_	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
4	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	synergistically	synergistically	ADV	RB	_	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1046
# text = These results suggest that cooperation among NF-kappa B-, AP-1- and NF-AT-binding sequences is required for induction of the GM-CSF gene through PKC- and Ca2+- signaling pathways downstream of T cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
6	among	among	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	AT	at	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
33	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	through	through	ADP	IN	_	_	_	_	_
35	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	+-	+-	PUNCT	,	_	_	_	_	_
40	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
41	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
42	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1047
# text = Document 003002369 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002369	003002369	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1048
# text = Nasal NK- and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin's disease.
1	Nasal	Nasal	PROPN	NNP	Number=Sing	_	_	_	_
2	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
8	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
20	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	's	's	PART	POS	_	_	_	_	_
24	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1049
# text = Nasal T/NK-cell lymphomas can be further separated into those of natural killer (NK) cell lineage or of T-cell lineage, with differences in cellular phenotype, T-cell receptor (TcR) gene rearrangement and TcR transcript expression.
1	Nasal	Nasal	PROPN	NNP	Number=Sing	_	_	_	_
2	T/NK	T/NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	further	further	ADV	RB	_	_	_	_	_
9	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	TcR	Tcr	ADV	RBR	Degree=Cmp	_	_	_	_
42	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1050
# text = Both NK- and T-cell subtypes are closely associated with Epstein-Barr virus (EBV).
1	Both	both	CCONJ	CC	_	_	_	_	_
2	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	subtypes	subtype	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	closely	closely	ADV	RB	_	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1051
# text = In this study, EBV gene expression was determined in 23 cases of nasal lymphoma (NL) by in situ hybridisation (ISH), reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry (IH).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	23	23	NUM	CD	NumType=Card	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nasal	nasal	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NL	NL	INTJ	UH	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
22	hybridisation	hybridisation	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ISH	ISH	INTJ	UH	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	reverse	reverse	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	RT	Rt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	IH	IH	INTJ	UH	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1052
# text = Of the 23 cases, 19 were classified as NK-cell and 4 as T-cell tumours.
1	Of	of	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	23	23	NUM	CD	NumType=Card	_	_	_	_
4	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	19	19	NUM	CD	NumType=Card	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	classified	classify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	tumours	tumour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1053
# text = ISH for EBV-encoded small non-polyadenylated RNAs showed that all cases, whether NK or T, harboured EBV in virtually all tumour cells.
1	ISH	ISh	PROPN	NNP	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	encoded	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
7	non-polyadenylated	non-polyadenylated	ADJ	JJ	Degree=Pos	_	_	_	_
8	RNAs	RNA	NOUN	NNS	Number=Plur	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whether	whether	SCONJ	IN	_	_	_	_	_
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	harboured	harboure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	virtually	virtually	ADV	RB	_	_	_	_	_
23	all	all	DET	PDT	_	_	_	_	_
24	tumour	tumour	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1054
# text = RT-PCR demonstrated that NL of both subtypes expressed EBNAI of the QUK splice pattern, the latent membrane proteins, LMP1 and 2 and the BamHI A rightward transcripts in the absence of EBNA2 mRNAs, compatible with the latency type II pattern.
1	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-PCR	-PCR	PROPN	NNP	Number=Sing	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	NL	Nl	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	subtypes	subtype	NOUN	NNS	Number=Plur	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	EBNAI	EBNAI	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	QUK	QUK	PROPN	NNP	Number=Sing	_	_	_	_
14	splice	splice	NOUN	NN	Number=Sing	_	_	_	_
15	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
19	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	_
28	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	rightward	rightward	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	EBNA2	EBNA2	NUM	CD	NumType=Card	_	_	_	_
36	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
42	type	type	NOUN	NN	Number=Sing	_	_	_	_
43	II	ii	NUM	CD	NumType=Card	_	_	_	_
44	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1055
# text = In addition, analysis of EBV protein expression by IH revealed a heterogeneous pattern of EBV gene expression at the single-cell level consisting of both LMP1+ and LMP1- tumour cells, suggesting a mixture of latency I and II.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IH	IH	PROPN	NNP	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
14	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
41	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	II	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1056
# text = Although 2 early lytic transcripts, BZLF1 and BHRF1, were also detected in 13 and 10 cases, respectively, the lack of ZEBRA staining in any case indicates that these lytic transcripts are most likely expressed by rare cells in the biopsies entering lytic cycle.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	13	13	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	10	10	NUM	CD	NumType=Card	_	_	_	_
18	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
26	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	any	any	DET	DT	_	_	_	_	_
29	case	case	NOUN	NN	Number=Sing	_	_	_	_
30	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	most	most	ADV	RBS	_	_	_	_	_
37	likely	likely	ADV	RB	_	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	biopsies	biopsy	NOUN	NNS	Number=Plur	_	_	_	_
45	entering	enter	VERB	VBG	VerbForm=Ger	_	_	_	_
46	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
47	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1057
# text = The viral transcriptional pattern similar to that of nasopharyngeal carcinoma and Hodgkin's disease suggests that EBV can exploit common regulatory mechanisms for gene transcription in diverse host cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
10	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	's	's	PART	POS	_	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
15	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	exploit	exploit	VERB	VB	VerbForm=Inf	_	_	_	_
20	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
28	host	host	NOUN	NN	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1058
# text = Down-regulation of immunogenic proteins (EBNA2-EBNA6) in nasal lymphoma may enable tumour cells to evade host cytotoxic T-cell surveillance.
1	Down	down	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	EBNA2	EBNA2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	EBNA6	EBNA6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	nasal	nasal	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	enable	enable	VERB	VB	VerbForm=Inf	_	_	_	_
17	tumour	tumour	PRON	PRP$	Person=2|Poss=Yes|PronType=Prs	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	evade	evade	VERB	VB	VerbForm=Inf	_	_	_	_
21	host	host	NOUN	NN	Number=Sing	_	_	_	_
22	cytotoxic	cytotoxic	NOUN	NN	Number=Sing	_	_	_	_
23	T-	t-	PUNCT	:	_	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	surveillance	surveillance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1059
# text = Document 003002373 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002373	003002373	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1060
# text = Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
8	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
9	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1061
# text = Here, we report the functional expression of CD40 on human malignant melanomas (MMs).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
13	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	MMs	Mms	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1062
# text = Comparison of tumor specimen from MM precursor lesions, primary tumors, and metastases revealed that CD40 surface expression is down-regulated during tumor progression.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	specimen	speciman	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	MM	mm	NUM	CD	NumType=Card	_	_	_	_
7	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
8	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	_
15	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1063
# text = CD40 expression was confirmed in 7 human MM cell lines established from immunogenic primary tumors or metastases, whereas 11 cell lines established from advanced stages were CD40 negative.
1	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	MM	mm	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	11	11	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
23	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
26	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
29	negative	negative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1064
# text = CD40 expression could be enhanced in CD40-positive MM by stimulation with IFN-gamma and tumor necrosis factor-alpha but not by interleukin (IL)-1beta or CD40 triggering.
1	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	MM	mm	PROPN	NNP	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	ADV	RB	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
34	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1065
# text = CD40 ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8, tumor necrosis factor-a, and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB.
1	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
2	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	MM	mm	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	CD40L	CD40L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	murine	murine	PRON	PRP	_	_	_	_	_
10	L-	L-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
16	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
17	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
32	class	class	NOUN	NN	Number=Sing	_	_	_	_
33	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	class	class	NOUN	NN	Number=Sing	_	_	_	_
36	II	ii	NUM	CD	NumType=Card	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
51	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
58	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
59	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
62	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	also	also	ADV	RB	_	_	_	_	_
65	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
66	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
67	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
68	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
72	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
73	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
74	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
75	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1066
# text = Furthermore, CD40 ligation of a HLA-A2+, MelanA/MART1+
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
4	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	A2+	a2+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	MelanA	MelanA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	MART1	MART1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 1067
# text = MM
1	MM	mm	X	ADD	_	_	_	_	_

# sent_id = 1068
# text = cell line enhanced its susceptibility to specific lysis by a HLA-A2-restricted, MelanA/MART-1-specific
1	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	line	line	NOUN	NN	Number=Sing	_	_	_	_
3	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	A2	a2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	MelanA/	MelanA/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
18	MART	Mart	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1069
# text = CTL clone.
1	CTL	Ctl	ADJ	JJ	Degree=Pos	_	_	_	_
2	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1070
# text = Finally, CD40 ligation induced growth inhibition and apoptosis in MM.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
4	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1071
# text = These results indicate that CD40-CD40L interactions may play an important role in augmenting antitumor immunity and inducing apoptosis in some CD40-positive immunogenic human MMs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD40-	Cd40-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
7	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
15	antitumor	antitumor	NOUN	NN	Number=Sing	_	_	_	_
16	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	some	some	DET	DT	_	_	_	_	_
22	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	MMs	MM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1072
# text = Document 003002382 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002382	003002382	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1073
# text = Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
4	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	S6	S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
25	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	type	type	NOUN	NN	Number=Sing	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1074
# text = Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
7	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	aa565-	aa565-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	647	647	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
21	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
24	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	-10	-10	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	production	production	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1075
# text = The signal cascade transducing this effect is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
4	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	yet	yet	ADV	RB	_	_	_	_	_
10	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1076
# text = In this study, we examined whether gp41-induced IL-10 up-regulation is mediated by the previously described synergistic activation of cAMP and NF-kappaB pathways.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	gp41	gp41	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1077
# text = gp41 induced cAMP accumulation in monocytes in a time- and concentration-dependent manner and the adenylate cyclase inhibitor SQ 22536 suppressed gp41-induced IL-10 production in monocytes.
1	gp41	gp41	X	LS	_	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
4	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
19	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
21	SQ	sq	NOUN	NN	Number=Sing	_	_	_	_
22	22536	22536	NUM	CD	NumType=Card	_	_	_	_
23	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	gp41	gp41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	production	production	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1078
# text = In contrast, gp41 failed to stimulate NF-kappaB binding activity in as much as no NF-kappaB bound to the main NF-kappaB-binding site 2 of the IL-10 promoter after addition of gp41.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
5	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	no	no	DET	DT	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB-	kappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	10	10	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	after	after	ADP	IN	_	_	_	_	_
38	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1079
# text = We also examined the involvement of other signal transduction pathways.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1080
# text = Specific inhibitors of p70(S6)-kinase (rapamycin), and Gi protein (pertussis toxin), prevented induction of IL-10 production by gp41 in monocytes, while inhibitors of the phosphatidylinositol 3-kinase (PI 3-kinase) (wortmannin) and mitogen-activated protein kinase (MAPK) pathway (PD 98059) did not.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	S6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Gi	gi	PROPN	NNP	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	pertussis	pertussis	NOUN	NN	Number=Sing	_	_	_	_
19	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	10	10	NUM	CD	NumType=Card	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	while	while	SCONJ	IN	_	_	_	_	_
35	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
39	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PI	Pi	NUM	CD	NumType=Card	_	_	_	_
44	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	wortmannin	wortmannin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	_
60	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
61	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
62	PD	P	NOUN	NN	Number=Sing	_	_	_	_
63	98059	98059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
66	not	not	PART	RB	_	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1081
# text = Thus HIV-1 gp41-induced IL-10 up-regulation in monocytes may not involve NF-kappaB, MAPK, or PI 3-kinase activation, but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70(S6)-kinase activation.
1	Thus	thus	PROPN	NNP	Number=Sing	_	_	_	_
2	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	rather	rather	ADV	RB	_	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	operate	operate	VERB	VB	VerbForm=Inf	_	_	_	_
35	through	through	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
39	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	pertussis-	pertussis-	SYM	NFP	_	_	_	_	SpaceAfter=No
42	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
45	Gi	gi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
47	Go	go	PROPN	NNP	Number=Sing	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
51	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	S6	S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
57	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1082
# text = Document 003002383 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002383	003002383	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1083
# text = Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IKK1	IKK1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1084
# text = Mononuclear phagocytes play a major role in immune and inflammatory responses.
1	Mononuclear	Mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1085
# text = Bacterial lipopolysaccharide (LPS) induces monocytes to express a variety of genes by activating the NF-kappaB/Rel transcription factor family.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1086
# text = Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	IKK1	IKK1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1087
# text = Phosphorylation of the IkappaB cytoplasmic inhibitors, IkappaBalpha, IkappaBbeta, and IkappaBepsilon, by these kinases triggers proteolytic degradation and the release of NF-kappaB/Rel proteins into the nucleus.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IkappaBepsilon	IkappaBepsilon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
18	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
19	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	release	release	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
30	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	into	into	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1088
# text = At present, the role of the IKKs in LPS signaling has not been investigated.
1	At	at	ADP	IN	_	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IKKs	IKKs	PROPN	NNPS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1089
# text = Here, we report that LPS induces IKK activity in human monocytes and THP-1 monocytic cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	IKK	Ikk	NUM	CD	NumType=Card	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1090
# text = The kinetics of activation of kinase activity in monocytic cells are relatively slow with maximal activity observed at 60 min, which coincides with the degradation of IkappaBs and the nuclear translocation of NF-kappaB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	relatively	relatively	ADV	RB	_	_	_	_	_
13	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	60	60	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	coincides	coincide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IkappaBs	IkappaB	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1091
# text = In transfection experiments, overexpression of wild type IKK1, a dominant negative mutant IKK1 (K44M), or wild type IKK2 did not affect LPS-induced kappaB-dependent transcription in monocytic cells.
1	In	in	ADP	IN	_	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	wild	wild	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	IKK1	Ikk1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
15	IKK1	Ikk1	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	K44	K44	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	wild	wild	AUX	MD	VerbForm=Fin	_	_	_	_
23	type	type	VERB	VB	VerbForm=Inf	_	_	_	_
24	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
28	LPS	Lps	ADV	RB	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1092
# text = In contrast, a dominant negative mutant of IKK2 inhibited LPS induction of kappaB-dependent transcription in a dose-dependent manner.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1093
# text = These results indicate that LPS induction of kappaB-dependent gene expression in human monocytic cells requires activation of IKK2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1094
# text = Document 003002388 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002388	003002388	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1095
# text = GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.
1	GABP	GABp	SYM	NFP	_	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1096
# text = Triggering of the T-cell receptor-CD3 complex activates two major signal cascades in T lymphocytes, (i) Ca2+-dependent signal cascades and (ii) protein kinase cascades.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
13	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
14	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	i	i	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	Ca2+-	Ca2+-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
25	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
32	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1097
# text = Both signal cascades contribute to the induction of the interleukin 2 (IL-2) gene during T-cell activation.
1	Both	both	DET	DT	_	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
4	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1098
# text = Prominent protein kinase cascades are those that activate mitogen-activated protein (MAP) kinases.
1	Prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MAP	map	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1099
# text = We show here that c-Raf, which is at the helm of the classic MAP-Erk cascade, contributes to IL-2 induction through a distal enhancer element spanning the nucleotides from positions -502 to -413 in front of the transcriptional start site of the IL-2 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	helm	helm	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	classic	classic	ADJ	JJ	Degree=Pos	_	_	_	_
17	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Erk	Erk	PROPN	NNP	Number=Sing	_	_	_	_
20	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	element	element	NOUN	NN	Number=Sing	_	_	_	_
33	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	502	502	NUM	CD	NumType=Card	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	413	413	NUM	CD	NumType=Card	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	front	front	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
48	start	start	NOUN	NN	Number=Sing	_	_	_	_
49	site	site	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	2	2	NUM	CD	NumType=Card	_	_	_	_
55	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1100
# text = Induction of this distal IL-2 enhancer differs from induction of the proximal IL-2 promoter-enhancer, since it is induced by phorbol esters alone and independent from Ca2+ signals.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	since	since	SCONJ	IN	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
28	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
29	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	+	+	SYM	SYM	_	_	_	_	_
35	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1101
# text = In DNA-protein binding studies, we detected the binding of transcription factors GABP alpha and -beta to a dyad symmetry element (DSE) of the distal enhancer, which is formed by palindromic binding sites of Ets-like factors.
1	In	in	ADP	IN	_	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dyad	dyad	NOUN	NN	Number=Sing	_	_	_	_
23	symmetry	symmetry	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	DSE	DSE	INTJ	UH	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
38	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
44	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1102
# text = Introduction of point mutations suppressing GABP binding to the DSE interfered with the induction of the distal enhancer and the entire IL-2 promoter-enhancer, while overexpression of both GABP factors enhanced the IL-2 promoter-enhancer induction.
1	Introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	point	point	NOUN	NN	Number=Sing	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
6	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DSE	DSE	PROPN	NNP	Number=Sing	_	_	_	_
11	interfered	interfer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	both	both	DET	DT	_	_	_	_	_
33	GABP	GABP	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1103
# text = Overexpression of BXB, a constitutive active version of c-Raf, and of further members of the Ras-Raf-Erk signal cascade exerted an increase of GABP-mediated promoter-enhancer induction.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	BXB	BXB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	version	version	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
17	members	member	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Erk	Erk	PROPN	NNP	Number=Sing	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
27	exerted	exert	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1104
# text = In conjunction with previously published data on c-Raf-induced phosphorylation of GABP factors (E.Flory, A.
1	In	in	ADP	IN	_	_	_	_	_
2	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	previously	previously	ADV	RB	_	_	_	_	_
5	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	data	data	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	E.Flory	E.Flory	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1105
# text = Hoffmeyer, U.Smola, U.R.Rapp, and J.T.Bruder, J.Virol.70:2260- 2268, 1996), these results indicate a contribution of GABP factors to the Raf-mediated enhancement of IL-2 induction during T-cell activation.
1	Hoffmeyer	Hoffmeyer	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	U.Smola	U.Smola	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	U.R.Rapp	U.R.Rapp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	J.T.Bruder	J.T.Bruder	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	J.Virol	J.Virol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	.70:2260	.70:2260	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	_
13	2268	2268	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	1996	1996	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	GABP	Gabp	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
37	during	during	ADP	IN	_	_	_	_	_
38	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1106
# text = Document 003002389 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002389	003002389	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1107
# text = Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
11	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1108
# text = Dimerization among transcription factors has become a recurrent theme in the regulation of eukaryotic gene expression.
1	Dimerization	Dimerization	NOUN	NN	Number=Sing	_	_	_	_
2	among	among	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	recurrent	recurrent	ADJ	JJ	Degree=Pos	_	_	_	_
9	theme	theme	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1109
# text = Hepatocyte nuclear factor-1 alpha (HNF-1 alpha) is a homeodomain-containing protein that functions as a dimer.
1	Hepatocyte	Hepatocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1110
# text = A dimerization cofactor of HNF-1 alpha (DCoH) was identified that displayed a restricted tissue distribution and did not bind to DNA, but, rather, selectively stabilized HNF-1 alpha dimers.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
3	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
19	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	rather	rather	ADV	RB	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	selectively	selectively	ADV	RB	_	_	_	_	_
32	stabilized	stabilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1111
# text = The formation of a stable tetrameric DCoH-HNF-1 alpha complex, which required the dimerization domain of HNF-1 alpha, did not change the DNA binding characteristics of HNF-1 alpha, but enhanced its transcriptional activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
6	tetrameric	tetrameric	NOUN	NN	Number=Sing	_	_	_	_
7	DCoH	DCoH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	change	change	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1112
# text = However, DCoH did not confer transcriptional activation to the GAL4 DNA binding domain.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	GAL4	Gal4	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1113
# text = These results indicate that DCoH regulates formation of transcriptionally active tetrameric complexes and may contribute to the developmental specificity of the complex.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
10	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
11	tetrameric	tetrameric	ADJ	JJ	Degree=Pos	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
19	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1114
# text = Document 003002390 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002390	003002390	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1115
# text = Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-alpha generation, on activation of nuclear factor-kappa B. (2E)-3-[5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid (E3330), is a novel agent with hepatoprotective activity.
1	Inhibitory	Inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	quinone	quinone	NOUN	NN	Number=Sing	_	_	_	_
9	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor-kappa	factor-kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	2E	2E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	3-[	3-[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	5-(	5-(	SYM	NFP	_	_	_	_	SpaceAfter=No
32	2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2	2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	_
34	propenoic	propenoic	ADJ	JJ	Degree=Pos	_	_	_	_
35	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	E3330	E3330	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
43	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	hepatoprotective	hepatoprotective	ADJ	JJ	Degree=Pos	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1116
# text = We report the effect of E3330 on transcriptional activation of tumor necrosis factor (TNF)-alpha gene and on nuclear factor (NF)-kappa B activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	E3330	E3330	NUM	CD	NumType=Card	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1117
# text = Nuclear run-on experiments showed that E3330 decreases transcriptional activation of TNF-alpha gene induced by lipopolysaccharide (LPS) stimulation in human peripheral monocytes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
9	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1118
# text = To investigate the inhibitory mechanisms, we constructed a secreted-type placental alkaline phosphatase (PLAP) reporter gene whose transcription is controlled by a 1.4-kb human TNF-alpha promoter.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	constructed	construct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	placental	placental	NOUN	NN	Number=Sing	_	_	_	_
14	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
15	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PLAP	PLAP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	1.4	1.4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1119
# text = A stable transformant of the PLAP reporter gene derived from human monocytic cell line showed very little activity on the promoter before stimulation, whereas LPS stimulation led to a dramatic increase in PLAP activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
3	transformant	transformant	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PLAP	PLAP	PROPN	NNP	Number=Sing	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	very	very	ADV	RB	_	_	_	_	_
17	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	before	before	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
32	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	PLAP	Plap	NOUN	NN	Number=Sing	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1120
# text = E3330 inhibited this induced promoter activity in a dose-dependent manner.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1121
# text = There are four putative NF-kappa B binding sites (kappa B-1, kappa B-2, kappa B-3, kappa B-4) in human TNF-alpha promoter.
1	There	there	PRON	EX	_	_	_	_	_
2	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	four	four	NUM	CD	NumType=Card	_	_	_	_
4	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1122
# text = By using mutated promoter-PLAP plasmids, we established that these NF-kappa B sites were necessary for induction of TNF-alpha transcription on stimulation with LPS.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	PLAP	pLAp	NOUN	NN	Number=Sing	_	_	_	_
7	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	established	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1123
# text = A gel retardation experiment with synthetic double-stranded oligonucleotides showed that activated NF-kappa B consisting of p50/p65 heterodimer bound to all four putative NF-kappa B DNA probes, suggesting that all four putative NF-kappa B recognition sites play an important role in inducible TNF-alpha expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
4	experiment	experiment	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	p65	p65	NUM	CD	NumType=Card	_	_	_	_
23	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
24	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	all	all	DET	DT	_	_	_	_	_
27	four	four	NUM	CD	NumType=Card	_	_	_	_
28	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	probes	probe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	all	all	DET	DT	_	_	_	_	_
39	four	four	NUM	CD	NumType=Card	_	_	_	_
40	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
41	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
46	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
47	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
50	role	role	NOUN	NN	Number=Sing	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
53	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1124
# text = E3330 decreased activated NF-kappa B in nuclei, suggesting that E3330 inhibits NF-kappa B activation and/or translocation of the nuclei.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
14	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	or	or	CCONJ	CC	_	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1125
# text = Western blotting analysis with anti-I kappa B-alpha antibody indicated that E3330 inhibited degradation of I kappa B-alpha, which is an inhibitory protein of NF-kappa B, in LPS-stimulated monocytes.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blott	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
6	-I	-i	X	AFX	_	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
10	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
11	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
14	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1126
# text = E3330 may suppress the production of active oxygen species serving as common messengers to activate NF-kappa B.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
9	species	species	NOUN	NNS	Number=Plur	_	_	_	_
10	serving	serve	VERB	VBG	VerbForm=Ger	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1127
# text = Document 003002392 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002392	003002392	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1128
# text = Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B [published erratum appears in Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3632]
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
9	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
28	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Proc	Proc	PROPN	NNP	Number=Sing	_	_	_	_
31	Natl	Natl	PROPN	NNP	Number=Sing	_	_	_	_
32	Acad	Acad	PROPN	NNP	Number=Sing	_	_	_	_
33	Sci	sci	PROPN	NNP	Number=Sing	_	_	_	_
34	U	U	PROPN	NNP	Number=Sing	_	_	_	_
35	S	be	PART	POS	_	_	_	_	_
36	A	a	PROPN	NNP	Number=Sing	_	_	_	_
37	1995	1995	NUM	CD	NumType=Card	_	_	_	_
38	Apr	Apr	PROPN	NNP	Number=Sing	_	_	_	_
39	11;92	11;92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	8):3632	8):3632	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1129
# text = The host response to Mycobacterium tuberculosis includes granuloma formation at sites of infection and systemic symptoms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	host	host	NOUN	NN	Number=Sing	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
6	tuberculosis	tuberculosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	granuloma	granuloma	NOUN	NN	Number=Sing	_	_	_	_
9	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
16	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1130
# text = Cytokines have been identified by immunohistochemistry in granulomas in animal models of bacillus Calmette-Guerin (BCG) infection and are released by mononuclear phagocytes upon stimulation by mycobacterial proteins.
1	Cytokines	Cytokine	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	granulomas	granuloma	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
11	models	model	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	bacillus	bacillus	ADJ	JJ	Degree=Pos	_	_	_	_
14	Calmette	Calmette	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Guerin	Guerin	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	BCG	BCG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	released	release	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
27	upon	upon	ADP	IN	_	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1131
# text = In this regard, the cytokine interleukin 6 (IL-6) may play a role in the clinical manifestations and pathological events of tuberculosis infection.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
21	manifestations	manifestation	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	tuberculosis	tuberculosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1132
# text = We have demonstrated that lipoarabinomannan (LAM) from the mycobacterial cell wall, which was virtually devoid of lipopolysaccharide (LPS), stimulated mononuclear phagocytes to release IL-6 in a dose-response manner.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	lipoarabinomannan	lipoarabinomannan	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LAM	LAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	wall	wall	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	virtually	virtually	ADV	RB	_	_	_	_	_
18	devoid	devoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	response	response	NOUN	NN	Number=Sing	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1133
# text = LAM and LPS were potent inducers of IL-6 gene expression in peripheral blood monocytes.
1	LAM	LAM	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
6	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1134
# text = Both LAM- and LPS-inducible IL-6 promoter activity was localized to a DNA fragment, positions -158 to -49, by deletion analysis and chloramphenicol acetyltransferase assay.
1	Both	both	DET	DT	_	_	_	_	_
2	LAM	LAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	158	158	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	49	49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
29	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
32	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
33	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1135
# text = Two nuclear factor NF-IL6 (positions -153 to -145 and -83 to -75) and one nuclear factor NF-kappa B (positions -72 to -63) motifs are present within this fragment.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	153	153	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	145	145	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	83	83	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	72	72	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	63	63	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
40	within	within	ADP	IN	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1136
# text = Site-directed mutagenesis of one or more of these motifs within the IL-6 promoter demonstrated that each has positive regulatory activity and that they could act in a function- and orientation-independent manner.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	each	each	DET	DT	_	_	_	_	_
21	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	orientation	orientation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1137
# text = Deletion of all three elements abolished inducibility of IL-6 promoter activity by both LAM and LPS.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	LAM	LAm	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1138
# text = We conclude that the NF-IL6 and NF-kappa B sites mediate IL-6 induction in response to both LPS and LAM, acting as bacterial or mycobacterial response elements.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	LAM	LAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1139
# text = Document 003002394 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002394	003002394	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1140
# text = Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain.
1	Homodimerization	Homodimerization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	Cepsilon	Cepsilon	ADP	IN	_	_	_	_	_
12	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
13	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
26	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1141
# text = The cytokines interleukin (IL)-4 and IL-13 play a critical role in inducing Cepsilon germline transcripts and IgE isotype switching in human B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	13	13	NUM	CD	NumType=Card	_	_	_	_
13	play	play	NOUN	NN	Number=Sing	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	SCONJ	IN	_	_	_	_	_
18	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
19	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
20	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
21	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
24	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
25	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1142
# text = The IL-4 receptor (IL-4R) in B cells is composed of two chains, the IL-4-binding IL-4Ralpha chain, which is shared with the IL-13R, and the IL-2Rgamma (gammac) chain, which is shared with IL-7R, IL-9R, and IL-15R.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4R	4r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-binding	-binding	NOUN	NN	Number=Sing	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
29	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	shared	share	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	13R	13r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	Rgamma	Rgamma	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	which	which	PRON	WDT	PronType=Rel	_	_	_	_
52	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	shared	share	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
54	with	with	ADP	IN	_	_	_	_	_
55	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	7R	7R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	9R	9R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	15R.	15R.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1143
# text = IL-4 induces Cepsilon germline transcripts and IgE isotype switching in B cells from patients with gammac chain deficiency.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
6	germline	germline	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IgE	IgE	NOUN	NN	Number=Sing	_	_	_	_
10	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
11	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
20	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1144
# text = Induction of Cepsilon germline transcripts by IL-4 in B cells that lack the gammac chain may involve signaling via the IL-13R.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
4	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
17	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
20	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	13R	13R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1145
# text = Alternatively, the IL-4Ralpha chain may transduce intracellular signals that lead to Cepsilon gene transcription independently of its association with other chains.
1	Alternatively	Alternatively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	Ralpha	Ralpha	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
17	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	independently	independently	ADV	RB	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	association	association	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1146
# text = We show that ligand-induced homodimerization of chimeric surface receptors consisting of the extracellular and transmembrane domains of the erythropoietin receptor and of the intracellular domain of IL-4Ralpha induces Janus kinase 1 (Jak1) activation, STAT6 activation, and Cepsilon germline transcripts in human B cell line BJAB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	homodimerization	homodimerization	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	transmembrane	transmembrane	ADJ	JJ	Degree=Pos	_	_	_	_
18	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
33	induces	induce	PROPN	NNPS	Number=Plur	_	_	_	_
34	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
35	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	Jak1	Jak1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
47	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
48	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
51	B	b	NOUN	NN	Number=Sing	_	_	_	_
52	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
53	line	line	NOUN	NN	Number=Sing	_	_	_	_
54	BJAB	bJAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1147
# text = Disruption of the Jak1-binding proline-rich Box1 region of IL-4Ralpha abolished signaling by this chimeric receptor.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proline	proline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
10	Box1	box1	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	for	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
17	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1148
# text = Furthermore, B cells transfected with a chimeric CD8alpha/IL-4Ralpha receptor, which is expressed on the cell surface as a homodimer, constitutively expressed Cepsilon germline transcripts.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	chimeric	chimeric	NOUN	NN	Number=Sing	_	_	_	_
9	CD8alpha/	Cd8alpha/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	constitutively	constitutively	ADV	RB	_	_	_	_	_
28	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
30	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
31	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1149
# text = These results suggest that homodimerization of the IL-4Ralpha chain is sufficient to transduce Jak1-dependent intracellular signals that lead to IgE isotype switching.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	homodimerization	homodimerization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
12	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
17	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	IgE	Ige	VERB	VB	VerbForm=Inf	_	_	_	_
26	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
27	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1150
# text = Document 003002395 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002395	003002395	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1151
# text = The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-activator	-activator	NOUN	NN	Number=Sing	_	_	_	_
6	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
7	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	TAFII32	Tafii32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1152
# text = The class II trans- activator (CIITA) is the main transcriptional co-activator for the expression of MHC class II proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	co-activator	co-activator	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1153
# text = Its N-terminal 125 amino acids function as an independent transcriptional activation domain.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
4	125	125	NUM	CD	NumType=Card	_	_	_	_
5	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
6	acids	acids	NOUN	NNS	Number=Plur	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1154
# text = Analyses of the primary amino acid sequence of the activation domain predict the presence of three alpha-helices, each with a high proportion of acidic residues.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	amino	amino	X	GW	_	_	_	_	_
6	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	predict	predict	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	helices	helice	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	each	each	DET	DT	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
25	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
28	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1155
# text = Using site-directed mutagenesis, we found that two of these predicted alpha-helices are required for full transcriptional activation by CIITA.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	helices	helice	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1156
# text = Moreover, a CIITA protein in which both functional alpha-helices have been deleted displays a dominant negative phenotype.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	helices	helice	NOUN	NNS	Number=Plur	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1157
# text = This activation domain of CIITA interacts with the 32 kDa subunit of the general transcription complex TFIID, TAFII32.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	32	32	NUM	CD	NumType=Card	_	_	_	_
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	TAFII32	TAFII32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1158
# text = Decreased transcriptional activation by N-terminal deletions of CIITA is correlated directly with their reduced binding to TAFII32.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
7	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	directly	directly	ADV	RB	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	TAFII32	Tafii32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1159
# text = We conclude that interactions between TAFII32 and CIITA are responsible for activation of class II genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	TAFII32	Tafii32	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1160
# text = Document 003002398 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002398	003002398	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1161
# text = Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1162
# text = Convergence of costimulatory signals and differences from transformed T cells.
1	Convergence	Convergence	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1163
# text = To study transcriptional regulation in normal human T cells, we have optimized conditions for transient transfection.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	optimized	optimize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1164
# text = Interleukin-2 (IL-2) promoter-reporter gene behavior closely parallels the endogenous gene in response to T cell receptor and costimulatory signals.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
14	closely	closely	ADV	RB	_	_	_	_	_
15	parallels	parallel	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1165
# text = As assessed with mutagenized promoters, the most important IL-2 cis-regulatory elements in normal T cells are the proximal AP-1 site and the NF- kappaB site.
1	As	as	SCONJ	IN	_	_	_	_	_
2	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	mutagenized	mutagenize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	most	most	ADV	RBS	_	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	_
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1166
# text = Both primary activation, with phytohemagglutinin or antibodies to CD3, and costimulation, provided by pairs of CD2 antibodies or B7-positive (B cells) or B7-negative (endothelial) accessory cells, are mediated through the same cis-elements.
1	Both	both	DET	DT	_	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
20	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
44	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1167
# text = Interestingly, the nuclear factor of activated T cell sites are much less important in normal T cells than in Jurkat T cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	much	much	ADV	RB	_	_	_	_	_
13	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1168
# text = We conclude that IL-2 transcriptional regulation differs in tumor cell lines compared with normal T cells and that different costimulatory signals converge on the same cis-elements in the IL-2 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
14	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
23	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
24	converge	converge	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
28	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1169
# text = Document 003002407 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002407	003002407	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1170
# text = IL-2-mediated cell cycle progression and inhibition of apoptosis does not require NF-kappa B or activating protein-1 activation in primary human T cells.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
8	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1171
# text = The IL-2 growth hormone is the major growth factor of activated T lymphocytes during a developing immune response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1172
# text = IL-2 is required not only for cell cycle progression but also to protect
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	not	not	ADV	RB	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
11	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 1173
# text = Ag-activated T cells from programmed cell death.
1	Ag-	Ag-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1174
# text = In several cell types, activation of NF-kappa B and/or activating protein-1 (AP-1) has been demonstrated to be extremely important in blocking apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	or	or	CCONJ	CC	_	_	_	_	_
15	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	X	LS	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	extremely	extremely	ADV	RB	_	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	SCONJ	IN	_	_	_	_	_
32	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
33	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1175
# text = To determine whether either or both of these transcription factors are involved in cell survival or cell cycle progression in response to IL-2, primary human T cells responsive to the growth factor were analyzed for NF-kappa B and AP-1 activation.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	either	either	DET	DT	_	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
19	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	B	b	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1176
# text = The current study clearly demonstrates that IL-2 does not induce I kappa B alpha degradation or NF-kappa B activation in primary human T cells that respond to IL-2 by entering the cell cycle and avoiding apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	clearly	clearly	ADV	RB	_	_	_	_	_
5	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	T	t	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	by	by	SCONJ	IN	_	_	_	_	_
36	entering	enter	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	avoiding	avoid	VERB	VBG	VerbForm=Ger	_	_	_	_
42	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1177
# text = Similarly, IL-2 neither activates JNK nor increases AP-1 binding activity to a consensus o-tetradecanoylphorbol 13-acetate (TPA) response element.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	neither	neither	NOUN	NN	Number=Sing	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	JNK	Jnk	PROPN	NNP	Number=Sing	_	_	_	_
9	nor	nor	CCONJ	CC	_	_	_	_	_
10	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	o-	o-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
21	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1178
# text = On the other hand, the growth factor does induce the activation of STAT3 and STAT5 in these cells, as has been previously demonstrated.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT5	STAT5	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	previously	previously	ADV	RB	_	_	_	_	_
25	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1179
# text = These data show that neither NF-kappa B nor AP-1 activation is required for IL-2-mediated survival or cell cycle progression in activated primary human T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	neither	neither	DET	DT	_	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	nor	nor	CCONJ	CC	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
27	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1180
# text = Document 003002409 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002409	003002409	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1181
# text = Transcription factor
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1182
# text = NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1183
# text = The POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	POU	pou	NOUN	NN	Number=Sing	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	to	NUM	CD	NumType=Card	_	_	_	_
11	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
22	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1184
# text = Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS).
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	primarily	primarily	ADV	RB	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
36	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1185
# text = However, the precise factors that mediate this induction mechanism remain unknown.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
11	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1186
# text = In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	monitored	monitor	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	arrested	arrest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
27	member	member	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1187
# text = Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1188
# text = This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
4	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	block	block	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1189
# text = The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	under	under	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	highlights	highlight	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	cross-talk	cross-talk	NOUN	NN	Number=Sing	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	families	family	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1190
# text = Document 003002412 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002412	003002412	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1191
# text = Interleukin 10 induced c-fos expression in human B cells by activation of divergent protein kinases.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	10	10	NUM	CD	NumType=Card	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1192
# text = IL-10 is a potent mediator of human B cell growth and plasma cell formation.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1193
# text = However, signal transduction of IL-10 in B cells is poorly understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	signal	signal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	poorly	poorly	ADV	RB	_	_	_	_	_
14	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1194
# text = In this study the effect of IL-10 on the expression of the protooncogene c-fos was investigated, because Fos plays a potential role in the regulation of B cell proliferation and differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	protooncogene	protooncogene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	because	because	SCONJ	IN	_	_	_	_	_
23	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
24	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1195
# text = B cells were purified from buffy coat preparations of healthy blood donors by positive selection using an anti CD20 monoclonal antibody and a MiniMACS separation unit.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	buffy	buffy	NOUN	NN	Number=Sing	_	_	_	_
7	coat	coat	NOUN	NN	Number=Sing	_	_	_	_
8	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	anti	anti	X	AFX	_	_	_	_	_
19	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
20	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
21	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	MiniMACS	MiniMACS	PROPN	NNP	Number=Sing	_	_	_	_
25	separation	separation	NOUN	NN	Number=Sing	_	_	_	_
26	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1196
# text = B cells were prestimulated with SAC for 48 hrs.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	prestimulated	prestimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	SAC	Sac	PROPN	NNP	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	48	48	NUM	CD	NumType=Card	_	_	_	_
9	hrs	hr	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1197
# text = Then, cells were incubated with medium or IL-10 (100 ng/ml) for 10 to 120 min.
1	Then	then	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IL-10	IL-10	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	100	100	NUM	CD	NumType=Card	_	_	_	_
12	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	120	120	NUM	CD	NumType=Card	_	_	_	_
19	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1198
# text = RNA was extracted by phenol/chloroform and c-fos expression was analyzed by PCR assisted mRNA assay.
1	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	phenol	phenol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	chloroform	chloroform	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	_
17	assisted	assist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1199
# text = A significant 2-4 fold increase of c-fos expression was observed within 30 min of stimulation with IL-10 (p < 0.01).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	30	30	NUM	CD	NumType=Card	_	_	_	_
17	min	min	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	10	10	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	p	p	NOUN	NN	Number=Sing	_	_	_	_
26	<	<	PUNCT	-LRB-	_	_	_	_	_
27	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1200
# text = After 2 hrs c-fos expression declined to basal levels.
1	After	after	ADP	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	hrs	hr	NOUN	NNS	Number=Plur	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1201
# text = The effect of IL-10 was dose-dependent with a maximum stimulation using 100 ng/ml of IL-10.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	maximum	maximum	NOUN	NN	Number=Sing	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	100	100	NUM	CD	NumType=Card	_	_	_	_
17	ng/ml	ng/ml	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1202
# text = The IL-10 effect on c-fos expression was not blocked by polymyxin B. Using the tyrosine kinase inhibitor genistein (10 microM) a complete inhibition of IL-10 induced c-fos expression was observed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	polymyxin	polymyxin	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_
18	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
23	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
30	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	10	10	NUM	CD	NumType=Card	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1203
# text = In addition, H-7 (10 microM), a specific inhibitor of serine/threonine kinases, significantly blocked IL-10 mediated c-fos expression (p < 0.05).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	fos	fo	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	p	p	NOUN	NN	Number=Sing	_	_	_	_
33	<	<	PUNCT	-LRB-	_	_	_	_	_
34	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1204
# text = In conclusion, these data show that IL-10 induces c-fos expression in human B-cells by activation of tyrosine and serine/threonine kinases.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
12	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
27	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1205
# text = Since this is the first report on IL-10 induced signal transduction, these data may help to identify the intracellular mechanisms by which IL-10 stimulates human B-cells.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	report	report	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
13	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	data	data	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	help	help	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1206
# text = Document 003002422 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002422	003002422	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1207
# text = GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells.
1	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	share	share	NOUN	NN	Number=Sing	_	_	_	_
9	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	costimulatory	costimulatory	VERB	VB	VerbForm=Inf	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1208
# text = Antigen complexed with major histocompatibility complex class I or II molecules on the surface of antigen presenting cells interacts with the T cell receptor (TCR) on the surface of T cells and initiates an activation cascade.
1	Antigen	Antigen	PROPN	NNP	Number=Sing	_	_	_	_
2	complexed	complex	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
17	presenting	presenting	VERB	VBG	VerbForm=Ger	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1209
# text = So called costimulatory signals, mediated by other cell surface interactions or soluble cytokines produced by antigen presenting cells, are also required for complete T cell activation.
1	So	so	ADV	RB	_	_	_	_	_
2	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
18	presenting	presenting	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1210
# text = High levels of cytokine gene expression in T cells also required both TCR and costimulatory signals.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1211
# text = The granulocyte-macrophage colony-stimulating factor requires sequences in the promoter as well as a powerful enhancer located 3kb upstream to respond to TCR-like signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
5	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
23	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	like	like	ADP	IN	_	_	_	_	_
30	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1212
# text = These promoter and enhancer regions are mainly activated by the transcription factor nuclear factor of activated T cells (NFAT).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mainly	mainly	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1213
# text = The activation of NFAT by TCR signals has been well described for interleukin-2 (IL-2) and IL-4 gene transcription in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	well	well	ADV	RB	Degree=Pos	_	_	_	_
11	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1214
# text = Costimulatory signals, such as activation of the CD28 cell surface molecule on T cells, lead to activation through a distinct region of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter.
1	Costimulatory	Costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
2	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	lead	lead	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
29	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1215
# text = This region is termed the CK-1 or CD28RE and appears to bind specific members of the NF-kappa B family of transcription factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	termed	term	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	members	member	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1216
# text = Human T leukemia virus type 1 (HTLV-1) infects T cells and can lead to increase GM-CSF expression.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
20	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1217
# text = We have found that the HTLV-1 transactivator protein, tax, acts as a costimulatory signal for GM-CSF and IL-2 gene transcription, in that it can cooperate with TCR signals to mediate high level gene expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	SCONJ	IN	_	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
37	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
40	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
41	level	level	NOUN	NN	Number=Sing	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1218
# text = Tax activates the GM-CSF promoter through the CK-1/CD28RE region and also activates nuclear factor-kappa B binding to this region.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
7	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1/CD28RE	1/CD28RE	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1219
# text = However, other transcription factors or coactivators of NF-kappa B are required for tax activation but these remain to be identified.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	coactivators	coactivator	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1220
# text = The CK-1/CD28RE of GM-CSF shows a high degree of similarity to the IL-2 CD28RE and the IL-3 gene also contains a related region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1/CD28RE	1/CD28RE	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
9	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	also	also	ADV	RB	_	_	_	_	_
28	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1221
# text = This observation, together with the fact that both GM-CSF and IL-2 respond to TCR signals via NFAT, implies a high degree of conservation in the regulation of cytokine gene expression in T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	together	together	ADV	RB	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	respond	respond	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	TCR	TCR	VERB	VB	VerbForm=Inf	_	_	_	_
20	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	implies	imply	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	conservation	conservation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1222
# text = Document 003002426 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002426	003002426	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1223
# text = IL-7 reconstitutes multiple aspects of v-Abl-mediated signaling.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	reconstitutes	reconstitute	NOUN	NNS	Number=Plur	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1224
# text = The mechanism by which early lymphoid cells are selectively transformed by v-Abl is currently unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	currently	currently	ADV	RB	_	_	_	_	_
17	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1225
# text = Previous studies have shown constitutive activation of IL-4 and IL-7 signaling pathways, as measured by activation of Janus protein kinase (JAK)1, JAK3, STAT5, and STAT6, in pre-B cells transformed by v-Abl.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	7	7	NUM	CD	NumType=Card	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
40	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1226
# text = To determine whether activation of these cytokine signaling pathways by v-Abl is important in the cellular events induced by the Abelson murine leukemia virus, the effects of IL-4 and IL-7 on pre-B cells transformed with a temperature-sensitive v-Abl mutant were examined.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	events	event	NOUN	NNS	Number=Plur	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Abelson	Abelson	PROPN	NNP	Number=Sing	_	_	_	_
24	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	7	7	NUM	CD	NumType=Card	_	_	_	_
38	on	on	ADP	IN	_	_	_	_	_
39	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
40	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
48	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
50	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
51	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1227
# text = Whereas IL-4 had little or no effect, IL-7 delayed both the apoptosis and cell cycle arrest that occur upon v-Abl kinase inactivation.
1	Whereas	whereas	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	7	7	NUM	CD	NumType=Card	_	_	_	_
14	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
21	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1228
# text = IL-7 also delayed the decreases in the levels of c-Myc, Bcl-2, and Bcl-xL that occur upon loss of v-Abl kinase activity.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	delayed	delay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	xL	xL	AUX	MD	VerbForm=Fin	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1229
# text = IL-7 did not maintain v-Abl-mediated differentiation arrest of the pre-B cells, as activation of NF-kappaB and RAG gene transcription was unaffected by IL-7.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
7	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
16	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1230
# text = These results identify a potential role for IL-7 signaling pathways in transformation by v-Abl while demonstrating that a combination of IL-4 and IL-7 signaling cannot substitute for an active v-Abl kinase in transformed pre-B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	7	7	NUM	CD	NumType=Card	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
34	not	not	PART	RB	_	_	_	_	_
35	substitute	substitute	VERB	VB	VerbForm=Inf	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
39	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
42	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
46	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1231
# text = Document 003002431 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002431	003002431	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1232
# text = Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1233
# text = Human T-cell leukemia virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia (ATL).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1234
# text = The viral protein Tax induces the activation and nuclear translocalization of transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocalization	translocalization	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1235
# text = However, the HTLV-I genes including Tax are not expressed significantly in primary leukemic cells from ATL patients.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1236
# text = In this study, we examined the basis for NF-kappaB activation in freshly isolated leukemic cells from ATL patients.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	freshly	freshly	ADV	RB	_	_	_	_	_
16	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1237
# text = We found that leukemic cells from ATL patients, like HTLV-I-infected T-cell lines, display constitutive NF-kappaB DNA binding activity and increased degradation of IkappaBalpha (an inhibitor of NF-kappaB).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	ATL	ATL	ADJ	JJ	Degree=Pos	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	like	like	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I-	I-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	display	display	NOUN	NN	Number=Sing	_	_	_	_
20	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1238
# text = Whereas the NF-kappaB binding activity in Tax-expressing T-cell lines consisted mostly of p50/c-Rel, fresh ATL samples contained p50/p50 and p50/p65 heterodimers.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mostly	mostly	ADV	RB	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	p50/c	p50/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
23	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
24	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
25	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	p50/p50	p50/p50	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
30	p65	p65	NUM	CD	NumType=Card	_	_	_	_
31	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1239
# text = One T-cell line derived from ATL leukemic cells, TL-Om1, displayed constitutive NF-kappaB activity, as well as enhanced degradation of IkappaBalpha, despite the lack of detectable Tax expression.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	line	line	NOUN	NN	Number=Sing	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	_
8	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TL	TL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Om1	Om1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	despite	despite	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
35	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1240
# text = Interestingly, the NF-kappaB in TL-Om1 consists of p50/p50 and p50/p65 like that in fresh primary leukemic cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	TL	TL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	Om1	Om1	NUM	CD	NumType=Card	_	_	_	_
11	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50/	p50/	SYM	NFP	_	_	_	_	SpaceAfter=No
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
18	p65	p65	NUM	CD	NumType=Card	_	_	_	_
19	like	like	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
23	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1241
# text = Our results suggest that activation of NF-kappaB occurs through a Tax-independent mechanism in leukemic cells of ATL patients, possibly due to differential NF-kappaB subunit activation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	possibly	possibly	ADV	RB	_	_	_	_	_
25	due	due	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1242
# text = Document 003002435 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002435	003002435	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1243
# text = The retinoblastoma gene product negatively regulates transcriptional activation mediated by the human cytomegalovirus IE2 protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	negatively	negatively	ADV	RB	_	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
14	IE2	Ie2	NUM	CD	NumType=Card	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1244
# text = The IE2 gene product of human cytomegalovirus (HCMV) is one of a few viral regulatory proteins expressed immediately upon infection of the host cell.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IE2	IE2	NUM	CD	NumType=Card	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	immediately	immediately	ADV	RB	_	_	_	_	_
21	upon	upon	ADP	IN	_	_	_	_	_
22	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	host	host	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1245
# text = It is a potent transcriptional activator of many viral and cellular promoters.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1246
# text = We found that the retinoblastoma susceptibility gene product (Rb) dramatically suppressed this IE2 transactivation of various promoters.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
6	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	product	product	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	dramatically	dramatically	ADV	RB	_	_	_	_	_
13	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	IE2	IE2	NOUN	NN	Number=Sing	_	_	_	_
16	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1247
# text = However, unlike another tumor suppressor protein, p53, Rb did not have any significant effect on basal levels of transcription, suggesting that Rb specifically interacts with IE2 rather than other cellular factors involved in the general transcription machinery.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	unlike	unlike	ADP	IN	_	_	_	_	_
4	another	another	DET	DT	_	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
15	any	any	DET	DT	_	_	_	_	_
16	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
27	specifically	specifically	ADV	RB	_	_	_	_	_
28	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	IE2	Ie2	NUM	CD	NumType=Card	_	_	_	_
31	rather	rather	ADV	RB	_	_	_	_	_
32	than	than	ADP	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
36	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1248
# text = We found by protein-affinity chromatography that Rb in nuclear extracts or produced by in vitro translation directly bound to IE2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	chromatography	chromatography	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
17	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
18	directly	directly	ADV	RB	_	_	_	_	_
19	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IE2	IE2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1249
# text = Our results suggest that Rb may regulate the life cycle of HCMV, which is endemic in the human population.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	life	life	NOUN	NN	Number=Sing	_	_	_	_
10	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	endemic	endemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1250
# text = Furthermore, these data may provide new insights into the slow rate of HCMV DNA replication in cells and the possible involvement of HCMV in tumorigenesis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
7	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
8	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
12	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HCMV	Hcmv	NOUN	NN	Number=Sing	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
22	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	tumorigenesis	tumorigenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1251
# text = Document 003002440 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002440	003002440	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1252
# text = Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	death	death	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1253
# text = Programmed cell death is a process required for the normal development of an organism.
1	Programmed	programmed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	death	death	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	process	process	NOUN	NN	Number=Sing	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	development	development	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	organism	organism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1254
# text = One of the best understood apoptotic pathways occurs in T lymphocytes and is mediated by Fas/Fas ligand (FasL) interaction.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
5	understood	understand	NOUN	NN	Number=Sing	_	_	_	_
6	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
7	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
8	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	FasL	FasL	INTJ	UH	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1255
# text = During studies of apoptosis induced by T cell-receptor engagement, we identified ALG-4F, a truncated transcript that prevents T cell-receptor-induced FasL upregulation and cell death.
1	During	during	ADP	IN	_	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	ALG	ALG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	4F	4F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
31	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1256
# text = Overexpression of full-length ALG-4 induced transcription of FasL and, consequently, apoptosis.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	length	length	NOUN	NN	Number=Sing	_	_	_	_
6	ALG	Alg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	FasL	Fasl	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1257
# text = These results indicate that ALG-4 is necessary and sufficient for FasL expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ALG	ALG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1258
# text = Fas/FasL interaction initiates cell death in many other systems, and its dysregulation is a mechanism by which several pathologic conditions arise.
1	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	initiates	initiate	NOUN	NNS	Number=Plur	_	_	_	_
6	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	death	death	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	pathologic	pathologic	NOUN	NN	Number=Sing	_	_	_	_
23	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
24	arise	arise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1259
# text = Understanding the molecular mechanisms of FasL regulation could be very useful in elucidating how these diseases develop and in identifying potential therapeutic targets.
1	Understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	very	very	ADV	RB	_	_	_	_	_
11	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	elucidating	elucidat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	how	how	ADV	WRB	PronType=Int	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
17	develop	develop	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	in	in	SCONJ	IN	_	_	_	_	_
20	identifying	identify	VERB	VBG	VerbForm=Ger	_	_	_	_
21	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
22	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
23	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1260
# text = Document 003002446 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002446	003002446	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1261
# text = Inhibition of NF-AT signal transduction events by a dominant-negative form of calcineurin.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	AT	AT	ADJ	JJ	Degree=Pos	_	_	_	_
6	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
7	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	form	form	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1262
# text = An inhibitory, "dominant-negative," form of the calcineurin catalytic (A) subunit was prepared, which lacks the calmodulin-binding domain, autoinhibitory domain and most of its catalytic core but possesses the regulatory (B) subunit binding domain.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
9	"	"	PUNCT	''	_	_	_	_	_
10	form	form	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
14	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	calmodulin	calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	autoinhibitory	autoinhibitory	NOUN	NN	Number=Sing	_	_	_	_
31	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	core	core	NOUN	NN	Number=Sing	_	_	_	_
38	but	but	CCONJ	CC	_	_	_	_	_
39	possesses	possess	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	B	b	X	LS	_	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
46	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
47	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1263
# text = When tested for its ability to block calcineurin-dependent signaling in Jurkat cells, expression of this "B-subunit knock-out" (BKO) construct suppressed reporter gene activity driven by NF-AT, the pivotal promoter element for interleukin (IL)-2 gene induction.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
8	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
23	knock	knock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	out	out	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	"	"	PUNCT	''	_	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	BKO	BKO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
31	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
44	element	element	NOUN	NN	Number=Sing	_	_	_	_
45	for	for	ADP	IN	_	_	_	_	_
46	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	2	2	NUM	CD	NumType=Card	_	_	_	_
52	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
53	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1264
# text = Immunoprecipitation of epitope-labeled BKO demonstrated for the formation of a tight complex with endogenous B subunit in Jurkat cells, consistent with an inhibitory mechanism that involves the sequestration of the B subunit.
1	Immunoprecipitation	Immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	BKO	Bko	PROPN	NNP	Number=Sing	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	sequestration	sequestration	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1265
# text = Furthermore, the sharply reduced NF-AT activity produced by co-transfecting BKO could be "rescued" by overexpression of transfected B subunit, suggesting that depletion of this subunit was responsible for the inhibition.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	sharply	sharply	NOUN	NN	Number=Sing	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	co-transfecting	co-transfecting	VERB	VBG	VerbForm=Ger	_	_	_	_
13	BKO	Bko	PROPN	NNP	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
17	rescued	rescue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	"	"	PUNCT	''	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1266
# text = These data suggest the potential utility of agents that disrupt calcineurin-mediated signal transduction pathways by blocking formation of the catalytically active dimer of calcineurin A and B subunits.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	utility	utility	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	disrupt	disrupt	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	calcineurin-	calcineurin-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
18	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	catalytically	catalytically	ADV	RB	_	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
26	A	a	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1267
# text = Document 003002447 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002447	003002447	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1268
# text = Rel-deficient
1	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1269
# text = T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	exhibit	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1270
# text = The c-rel protooncogene encodes a subunit of the NF-kappa B-like family of transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
4	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
5	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1271
# text = Mice lacking
1	Mice	mouse	NOUN	NN	Number=Sing	_	_	_	_
2	lacking	lack	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1272
# text = Rel are defective in mitogenic activation of B and T lymphocytes and display impaired humoral immunity.
1	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	display	display	NOUN	NN	Number=Sing	_	_	_	_
14	impaired	impaire	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	humoral	humoral	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1273
# text = In an attempt to identify changes in gene expression that accompany the T-cell stimulation defects associated with the loss of Rel, we have examined the expression of cell surface activation markers and cytokine production in mitogen-stimulated Rel-/- T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	attempt	attempt	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
6	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	accompany	accompany	DET	PDT	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-/-	-/-	PUNCT	.	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1274
# text = The expression of cell surface markers including the interleukin 2 receptor alpha (IL-2R alpha) chain (CD25), CD69 and L-selectin (CD62) is normal in mitogen-activated Rel-/- T cells, but cytokine production is impaired.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
7	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CD25	CD25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CD69	CD69	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	L-selectin	L-selectin	PROPN	NNP	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	CD62	Cd62	X	LS	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-/-	-/-	PUNCT	.	_	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
43	production	production	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1275
# text = In Rel-/- splenic T cell cultures stimulated with phorbol 12-myristate 13-acetate and ionomycin, the levels of IL-3, IL-5, granulocyte- macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor alpha (TNF-alpha), and gamma interferon (IFN-gamma) were only 2- to 3-fold lower compared with normal T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-/-	-/-	PUNCT	.	_	_	_	_	_
4	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
14	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
34	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	tumor	tumor	ADP	IN	_	_	_	_	_
45	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
46	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
47	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
56	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	_
62	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
63	only	only	ADV	RB	_	_	_	_	_
64	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	_
66	to	to	ADP	IN	_	_	_	_	_
67	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
69	fold	fold	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
70	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
71	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
72	with	with	ADP	IN	_	_	_	_	_
73	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
74	T	t	PROPN	NNP	Number=Sing	_	_	_	_
75	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1276
# text = In contrast, anti-CD3 and anti-CD28 stimulated Rel-/- T cells, which fail to proliferate, make little or no detectable cytokines.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
7	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-/-	-/-	PUNCT	.	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	make	make	VERB	VB	VerbForm=Inf	_	_	_	_
19	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1277
# text = Exogenous IL-2, which restitutes the proliferative response of the anti-CD3- and anti-CD28-treated Rel-/- T cells, restores production of IL-5, TNF-alpha, and IFN-gamma, but not IL-3 and GM-CSF expression to approximately normal levels.
1	Exogenous	Exogenous	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	restitutes	restitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-treated	-treated	ADJ	JJ	Degree=Pos	_	_	_	_
18	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-/-	-/-	PUNCT	.	_	_	_	_	_
20	T	t	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	restores	restore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	3	3	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	PART	TO	_	_	_	_	_
50	approximately	approximately	ADV	RB	_	_	_	_	_
51	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1278
# text = In contrast to mitogen-activated Rel-/- T cells, lipopolysaccharide-stimulated Rel-/- macrophages produce higher than normal levels of GM-CSF.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	mitogen	mitogen	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-/-	-/-	PUNCT	.	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-/-	-/-	PUNCT	.	_	_	_	_	_
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1279
# text = These findings establish that Rel can function as an activator or repressor of gene expression and is required by T lymphocytes for production of IL-3 and GM-CSF.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1280
# text = Document 003002451 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002451	003002451	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1281
# text = Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.
1	Ligand	Ligand	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	estrogen	estrogen	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1282
# text = High-dose estrogen administration induces anemia in mammals.
1	High	high	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	dose	dose	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
5	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	anemia	anemion	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mammals	mammal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1283
# text = In chickens, estrogens stimulate outgrowth of bone marrow-derived erythroid progenitor cells and delay their maturation.
1	In	in	ADP	IN	_	_	_	_	_
2	chickens	chicken	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
5	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	outgrowth	outgrowth	ADP	IN	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
9	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	delay	delay	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1284
# text = This delay is associated with down-regulation of many erythroid cell-specific genes, including alpha- and beta-globin, band 3, band 4.1, and the erythroid cell-specific histone
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	delay	delay	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	band	band	NOUN	NN	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	band	band	NOUN	NN	Number=Sing	_	_	_	_
29	4.1	4.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	histone	histone	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1285
# text = H5.
1	H5	h5	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1286
# text = We show here that estrogens also reduce the number of erythroid progenitor cells in primary human bone marrow cultures.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	reduce	reduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	number	number	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
18	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
19	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1287
# text = To address potential mechanisms by which estrogens suppress erythropoiesis, we have examined their effects on GATA-1, an erythroid transcription factor that participates in the regulation of the majority of erythroid cell-specific genes and is necessary for full maturation of erythrocytes.
1	To	to	PART	TO	_	_	_	_	_
2	address	address	VERB	VB	VerbForm=Inf	_	_	_	_
3	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	estrogens	estrogen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
9	erythropoiesis	erythropoiesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	participates	participate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
44	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1288
# text = We demonstrate that the transcriptional activity of GATA-1 is strongly repressed by the estrogen receptor (ER) in a ligand-dependent manner and that this repression is reversible in the presence of 4-hydroxytamoxifen.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	estrogen	estrogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	hydroxytamoxifen	hydroxytamoxifen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1289
# text = ER-mediated repression of GATA-1 activity occurs on an artificial promoter containing a single GATA-binding site, as well as in the context of an intact promoter which is normally regulated by GATA-1.
1	ER-	ER-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	artificial	artificial	ADJ	JJ	Degree=Pos	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
17	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	context	context	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	normally	normally	ADV	RB	_	_	_	_	_
35	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1290
# text = GATA-1 and ER bind to each other in vitro in the absence of DNA.
1	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	ER	er	NOUN	NN	Number=Sing	_	_	_	_
6	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	each	each	DET	DT	_	_	_	_	_
9	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1291
# text = In coimmunoprecipitation experiments using transfected COS cells, GATA-1 and ER associate in a ligand-dependent manner.
1	In	in	ADP	IN	_	_	_	_	_
2	coimmunoprecipitation	coimmunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	COS	Cos	NOUN	NNS	Number=Plur	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	ER	er	NOUN	NN	Number=Sing	_	_	_	_
14	associate	associate	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1292
# text = Mapping experiments indicate that GATA-1 and the ER form at least two contacts, which involve the finger region and the N-terminal activation domain of GATA-1.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ER	er	NOUN	NN	Number=Sing	_	_	_	_
11	form	form	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	contacts	contact	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1293
# text = We speculate that estrogens exert effects on erythropoiesis by modulating GATA-1 activity through protein-protein interaction with the ER. (ABSTRACT TRUNCATED AT 250 WORDS)
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
5	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	erythropoiesis	erythropoiesis	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ABSTRACT	Abstract	ADV	RB	_	_	_	_	_
25	TRUNCATED	tRUNCATEd	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
26	AT	at	ADV	RB	_	_	_	_	_
27	250	250	NUM	CD	NumType=Card	_	_	_	_
28	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1294
# text = Document 003002452 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002452	003002452	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1295
# text = Anti-CD2 receptor antibodies activate the HIV long terminal repeat in T lymphocytes.
1	Anti-CD2	Anti-CD2	NUM	CD	NumType=Card	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
4	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
7	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
8	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
9	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1296
# text = The CD2 T lymphocyte glycoprotein surface molecule mediates both cell to cell adhesion and T cell activation, two processes that are involved in the spread of HIV infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
3	T	t	NUM	CD	NumType=Card	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	T	t	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	spread	spread	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
29	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1297
# text = Treatment of chronically HIV-infected PBMC with anti-CD2 mAb has been shown to induce the expression of infectious virus from these cultures.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	chronically	chronically	ADV	RB	_	_	_	_	_
4	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
9	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1298
# text = In this study we investigated the mechanisms whereby anti-CD2 antibodies stimulate viral production.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	whereby	whereby	ADV	RP	_	_	_	_	_
9	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
10	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
11	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1299
# text = We demonstrate that treatment of transiently transfected T lymphocytes with anti-CD2 antibodies results in activation of the HIV long terminal repeat.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transiently	transiently	ADV	RB	_	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
13	results	result	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
19	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
20	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
21	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1300
# text = Furthermore, CAT assays using mutated HIV long terminal repeat-CAT constructs and gel shift assays demonstrate that this activation is dependent on the NF-kappa B enhancer.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
8	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
9	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
10	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
13	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
18	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1301
# text = These studies suggest that interaction of CD2 with its natural ligand, LFA-3, may play a role in regulation of HIV expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
11	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1302
# text = Document 003002459 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002459	003002459	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1303
# text = Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation.
1	Defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	C	c	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	multidrug	multidrug	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
11	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	confers	confer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
18	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
21	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1304
# text = Previous studies have demonstrated that human HL-60 myeloid leukemia cells differentiate in response to phorbol esters.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	60	60	NUM	CD	NumType=Card	_	_	_	_
10	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	differentiate	differentiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
18	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1305
# text = This event is associated with induction of the c-jun early response gene and appearance of a monocytic phenotype.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	event	event	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	jun	jun	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1306
# text = The present studies have examined the effects of vincristine-selected, multidrug resistance on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced HL-60 cell differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	vincristine	vincristine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	multidrug	multidrug	VERB	VBG	VerbForm=Ger	_	_	_	_
14	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	O	of	INTJ	UH	_	_	_	_	SpaceAfter=No
19	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
20	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	60	60	NUM	CD	NumType=Card	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1307
# text = The results demonstrate that multidrug-resistant HL-60 cells, designated HL-60/vinc, fail to respond to TPA with an increase in c-jun transcripts or other phenotypic characteristics of monocytic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	multidrug	multidrug	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
8	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	60	60	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
31	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
35	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1308
# text = By contrast, treatment of HL-60/vinc cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases, induces c-jun transcription, growth arrest, and expression of the c-fms gene.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
14	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
26	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
27	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
31	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	fms	fm	NOUN	NNS	Number=Plur	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1309
# text = Studies were also performed with an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
12	revertant	revertant	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	HL-	HL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	vinc/R	vinc/R	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	regained	regaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
24	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	vincristine	vincristine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1310
# text = The finding that HL-60/vinc/R cells respond to TPA with induction of a monocytic phenotype, but not c-jun expression, suggests that c-jun induction is not obligatory for monocytic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	HL-60/vinc/	HL-60/vinc/	SYM	NFP	_	_	_	_	SpaceAfter=No
5	R	r	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	obligatory	obligatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1311
# text = Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	fra	fra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	HL-60	HL-60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	/vinc	/vinc	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	HL-60/vinc/R	Hl-60/vinc/r	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	wherea	SCONJ	IN	_	_	_	_	_
27	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
39	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1312
# text = Since TPA activates protein kinase C (PKC), we examined translocation of PKC from the cytosol to the membrane fraction.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
22	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1313
# text = Although HL-60 and HL-60/vinc/R cells demonstrated translocation of PKC activity, this subcellular redistribution was undetectable in HL-60/vinc cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	60	60	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	HL-60/vinc/	HL-60/vinc/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	R	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	subcellular	subcellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	redistribution	redistribution	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1314
# text = Activity of the mitogen-activated protein kinase family with associated phosphorylation of c-Jun Y-peptide was markedly diminished in TPA-treated HL-60/vinc cells, but not in response to okadaic acid.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
17	Y-	y-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	markedly	markedly	ADV	RB	_	_	_	_	_
21	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	response	response	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
39	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1315
# text = Taken together, these findings suggest that vincristine resistance confers insensitivity to TPA-induced differentiation and can include defects in PKC-mediated signaling events and induction of jun/fos early response gene expression.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	vincristine	vincristine	ADJ	JJ	Degree=Pos	_	_	_	_
9	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
10	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
11	insensitivity	insensitivity	ADV	RB	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
20	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
26	events	event	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1316
# text = Document 003002466 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002466	003002466	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1317
# text = HMG-I binds to GATA motifs: implications for an HPFH syndrome.
1	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
7	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	HPFH	Hpfh	ADJ	JJ	Degree=Pos	_	_	_	_
13	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1318
# text = We have examined binding of the nuclear protein HMG-I to the human gamma-globin promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1319
# text = We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter; this paired motif is bound by the erythroid factor GATA-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HMG	Hmg	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	preferentially	preferentially	ADV	RB	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	paired	paired	ADJ	JJ	Degree=Pos	_	_	_	_
29	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1320
# text = A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells (HPFH) and up-regulation of the gamma-globin promoter in in vitro expression assays; HMG-I does not bind to this mutant sequence.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	naturally	naturally	ADV	RB	_	_	_	_	_
3	occurring	occurre	ADJ	JJ	Degree=Pos	_	_	_	_
4	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
5	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
6	175	175	NUM	CD	NumType=Card	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	area	area	NOUN	NN	Number=Sing	_	_	_	_
14	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
28	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
29	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	HPFH	HPFH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
48	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	;	;	PUNCT	,	_	_	_	_	_
50	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
51	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
52	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
53	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
54	not	not	PART	RB	_	_	_	_	_
55	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
56	to	to	ADP	IN	_	_	_	_	_
57	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
58	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
59	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1321
# text = A survey of GATA motifs from other globin cis-elements demonstrates HMG-I binding to most of them.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	survey	survey	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
5	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	HMG	Hmg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1322
# text = These findings implicate HMG-I in the HPFH phenotype; we speculate that it may participate in the formation of multiprotein complexes that regulate globin gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	implicate	implicate	ADJ	JJ	Degree=Pos	_	_	_	_
4	HMG	Hmg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HPFH	Hpfh	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	multiprotein	multiprotein	ADJ	JJ	Degree=Pos	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1323
# text = Document 003002468 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002468	003002468	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1324
# text = A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nongenomic	nongenomic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1325
# text = The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
7	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	remained	remain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	elusive	elusive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1326
# text = Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and reversibly blocks voltage-gated and calcium-activated K+ channels (KV and KCa, respectively), resulting in depolarization of the membrane potential.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	placenta	placenta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	rapidly	rapidly	ADV	RB	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	reversibly	reversibly	ADV	RB	_	_	_	_	_
25	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
26	voltage	voltage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gated	gate	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	calcium-	calcium-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	+	+	SYM	SYM	_	_	_	_	_
34	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	depolarization	depolarization	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
49	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1327
# text = As a result, Ca2+ signaling and nuclear factor of activated T cells (NF-AT)-driven gene expression are inhibited.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	result	result	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1328
# text = Progesterone acts distally to the initial steps of T cell receptor (TCR)-mediated signal transduction, since it blocks sustained Ca2+ signals after thapsigargin stimulation, as well as oscillatory Ca2+ signals, but not the Ca2+ transient after TCR stimulation.
1	Progesterone	Progesterone	PRON	NN	Number=Sing	_	_	_	_
2	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	distally	distally	ADV	RB	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
7	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	since	since	SCONJ	IN	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
23	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Ca2	ca2	PART	TO	Abbr=Yes	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	thapsigargin	thapsigargin	NOUN	NN	Number=Sing	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	as	as	ADV	RB	_	_	_	_	_
32	well	well	ADV	RB	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	oscillatory	oscillatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	_
37	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	+	+	SYM	SYM	_	_	_	_	_
44	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
45	after	after	ADP	IN	_	_	_	_	_
46	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
47	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1329
# text = K+
1	K	K	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 1330
# text = channel blockade by progesterone is specific; other steroid hormones had little or no effect, although the progesterone antagonist RU 486 also blocked KV and KCa channels.
1	channel	channel	NOUN	NN	Number=Sing	_	_	_	_
2	blockade	blockake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	;	;	PUNCT	,	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
11	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	although	although	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
20	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
21	RU	Ru	PROPN	NNP	Number=Sing	_	_	_	_
22	486	486	NUM	CD	NumType=Card	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	_
28	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1331
# text = Progesterone effectively blocked a broad spectrum of K+ channels, reducing both Kv1.3 and charybdotoxin-resistant components of KV current and KCa current in T cells, as well as blocking several cloned KV channels expressed in cell lines.
1	Progesterone	Progesterone	PROPN	NNP	Number=Sing	_	_	_	_
2	effectively	effectively	ADV	RB	_	_	_	_	_
3	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	broad	broad	ADJ	JJ	Degree=Pos	_	_	_	_
6	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	Kv1.3	Kv1.3	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	charybdotoxin	charybdotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
19	components	component	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
22	current	current	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	_
25	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	as	as	ADV	RB	_	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
34	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
35	cloned	clon	ADJ	JJ	Degree=Pos	_	_	_	_
36	KV	Kv	PROPN	NNP	Number=Sing	_	_	_	_
37	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1332
# text = Progesterone had little or no effect on a cloned voltage-gated Na+ channel, an inward rectifier K+ channel, or on lymphocyte Ca2+ and Cl- channels.
1	Progesterone	Progesterone	PRON	NN	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	voltage	voltage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gated	gate	ADJ	JJ	Degree=Pos	_	_	_	_
13	Na	na	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	+	+	SYM	SYM	_	_	_	_	_
15	channel	channel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inward	inward	ADJ	JJ	Degree=Pos	_	_	_	_
19	rectifier	rectifier	NOUN	NN	Number=Sing	_	_	_	_
20	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	channel	channel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	+	+	SYM	SYM	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Cl	Cl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	_
32	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1333
# text = We propose that direct inhibition of K+ channels in T cells by progesterone contributes to progesterone-induced immunosuppression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
15	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	progesterone	progesterone	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1334
# text = Document 003002472 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002472	003002472	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1335
# text = Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
9	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1336
# text = CD28 is an important costimulatory molecule in the activation of human T cells.
1	CD28	Cd28	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1337
# text = Costimulation of T cells through both the Ag receptor and CD28 leads to high level IL-2 production, which is vital to the development of an immune response in vivo.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Ag	ag	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	vital	vital	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1338
# text = Previous reports have suggested the CD28 stimulation contributes to the activation of the IL-2 promoter by up-regulating the activity of several transcription factors, including AP-1 and nuclear factor-kappaB (NF-kappaB)/Rel family members as well as an uncharacterized transcription factor called CD28 response complex.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
30	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
44	family	family	NOUN	NN	Number=Sing	_	_	_	_
45	members	member	NOUN	NNS	Number=Plur	_	_	_	_
46	as	as	ADV	RB	_	_	_	_	_
47	well	well	ADV	RB	Degree=Pos	_	_	_	_
48	as	as	ADP	IN	_	_	_	_	_
49	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	uncharacterized	uncharacterized	ADJ	JJ	Degree=Pos	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
53	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
55	response	response	NOUN	NN	Number=Sing	_	_	_	_
56	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1339
# text = While several lines of investigation have suggested that NF-kappaB/Rel family members make up the CD28 response complex transcription factor, other work has not supported this conclusion.
1	While	while	SCONJ	IN	_	_	_	_	_
2	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	members	member	NOUN	NNS	Number=Plur	_	_	_	_
16	make	make	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	up	up	ADP	RP	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	complex	complex	NUM	CD	NumType=Card	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	work	work	NOUN	NN	Number=Sing	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	supported	support	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1340
# text = Recent studies suggest that the CD28 response element (CD28RE) does not function independently but works instead in conjunction with the adjacent promoter proximal AP-1-binding site and this hypothesis is confirmed here.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
15	independently	independently	ADV	RB	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	works	work	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	instead	instead	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1341
# text = Also in the current study, binding activity to the CD28RE/AP-1 sequence of the IL-2 promoter is evaluated.
1	Also	also	ADV	RB	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1342
# text = Although four specific complexes can be detected binding to this sequence, only one of these complexes is specific for both the CD28RE and the adjacent AP-1 site.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	four	four	NUM	CD	NumType=Card	_	_	_	_
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1343
# text = Of the NF-kappaB/Rel family members tested, this CD28RE/AP-1-specific complex contains predominantly c-Rel, despite the fact that both p50 and RelA can efficiently bind to the CD28RE.
1	Of	of	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	predominantly	predominantly	ADV	RB	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	despite	despite	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	efficiently	efficiently	ADV	RB	_	_	_	_	_
36	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1344
# text = c-Fos and c-Jun are also found in this CD28RE/AP-1-specific complex.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1345
# text = These data indicate that functional complexes encompassing both the CD28RE and the AP-1-binding sites influence IL-2 promoter activity in CD28-costimulated T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
7	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1346
# text = Document 003002482 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002482	003002482	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1347
# text = Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion.
1	Monocyte	Monocyte	PROPN	NNP	Number=Sing	_	_	_	_
2	tethering	tether	VERB	VBG	VerbForm=Ger	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
8	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1348
# text = Signal integration and NF-kappa B translocation [see comments]
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1349
# text = Adhesion molecules that tether circulating leukocytes to endothelial cells may also transduce or modulate outside-in signals for cellular activation, providing an initial regulatory point in the inflammatory response.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	tether	tether	SCONJ	IN	_	_	_	_	_
5	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
15	outside	outside	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	in	in	ADP	IN	_	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	point	point	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1350
# text = Adhesion of human monocytes to P-selectin, the most rapidly expressed endothelial tethering factor, increased the secretion of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) by the leukocytes when they were stimulated with platelet-activating factor.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	most	most	ADV	RBS	_	_	_	_	_
11	rapidly	rapidly	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	tethering	tethering	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
22	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
33	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
44	when	when	ADV	WRB	PronType=Int	_	_	_	_
45	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
46	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	with	with	ADP	IN	_	_	_	_	_
49	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1351
# text = Increased cytokine secretion was specifically inhibited by G1, an anti-P-selectin mAb that prevents P-selectin from binding to its ligand (P-selectin glycoprotein ligand-1) on myeloid cells.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	cytokine	cytokine	PRON	PRP	_	_	_	_	_
3	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	anti-P-	anti-P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	SCONJ	IN	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
26	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
27	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	X	LS	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1352
# text = Moreover, tethering by P-selectin specifically enhanced nuclear translocation of nuclear factor-kappa B (NF-kappa B), a transcription factor required for expression of MCP-1, TNF-alpha, and other immediate-early genes.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tethering	tether	VERB	VBG	VerbForm=Ger	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
41	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
44	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1353
# text = These results demonstrate that P-selectin, through its ligands on monocytes, may locally regulate cytokine secretion in inflamed tissues.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	locally	locally	ADV	RB	_	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1354
# text = Document 003002487 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002487	003002487	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1355
# text = Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
18	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
21	Saimiri	Saimiri	PROPN	NNP	Number=Sing	_	_	_	_
22	STP	STP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1356
# text = The STP oncoproteins of the herpesvirus saimiri (HVS) subgroup A strain 11 and subgroup C strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (TRAF) 1, 2, or 3.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	STP	sTp	NOUN	NN	Number=Sing	_	_	_	_
3	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
7	saimiri	saimiri	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HVS	HVS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	subgroup	subgroup	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
14	11	11	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	subgroup	subgroup	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	C	C	PROPN	NNP	Number=Sing	_	_	_	_
18	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
19	488	488	NUM	CD	NumType=Card	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	now	now	ADV	RB	_	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	stably	stably	ADV	RB	_	_	_	_	_
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	TRAF	TRAF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1357
# text = Mutational analyses identified residues of PXQXT/S in STP-A11 as critical for TRAF association.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	PXQXT/	PXQXT/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	S	s	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	STP	STP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	A11	A11	PROPN	NNP	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	TRAF	Traf	PROPN	NNP	Number=Sing	_	_	_	_
16	association	association	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1358
# text = In addition, a somewhat divergent region of STP-C488 is critical for TRAF association.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	somewhat	somewhat	ADV	RB	_	_	_	_	_
6	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	STP-	Stp-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	C488	c488	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
15	association	association	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1359
# text = Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	STP-C488	STP-C488	PROPN	NNP	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	TRAFs	Trafs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1360
# text = The HVS STP-C488 P10-->R mutant was deficient in human T-lymphocyte transformation to interleukin-2-independent growth but showed wild-type phenotype for marmoset T-lymphocyte transformation in vitro and in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HVS	HVS	PROPN	NNP	Number=Sing	_	_	_	_
3	STP-C488	STP-C488	PROPN	NNP	Number=Sing	_	_	_	_
4	P10-->	P10-->	PUNCT	,	_	_	_	_	SpaceAfter=No
5	R	R	PROPN	NNP	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
13	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
20	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	marmoset	marmoset	NOUN	NN	Number=Sing	_	_	_	_
29	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
31	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1361
# text = The STP-C488 P10-->R mutant was also defective in Rat-1 fibroblast transformation, and fibroblast cell transformation was blocked by a TRAF2 dominant-negative mutant.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	STP-C488	Stp-c488	NUM	CD	NumType=Card	_	_	_	_
3	P10-->	P10-->	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	R	R	PROPN	NNP	Number=Sing	_	_	_	_
5	mutant	mutant	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Rat	Rat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	fibroblast	fibroblast	NOUN	NN	Number=Sing	_	_	_	_
14	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
25	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1362
# text = These data implicate TRAFs in STP-C488-mediated transformation of human lymphocytes and rodent fibroblasts.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	implicate	implicate	ADJ	JJ	Degree=Pos	_	_	_	_
4	TRAFs	TRAF	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	STP-C488	STP-C488	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	rodent	rodent	ADJ	JJ	Degree=Pos	_	_	_	_
15	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1363
# text = Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
9	marmoset	marmoset	NOUN	NN	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	rodent	rodent	ADJ	JJ	Degree=Pos	_	_	_	_
25	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1364
# text = Document 003002488 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002488	003002488	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1365
# text = Signal transduction abnormalities in T lymphocytes from patients with advanced renal carcinoma: clinical relevance and effects of cytokine therapy.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
11	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
12	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
15	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1366
# text = Studies have demonstrated abnormalities of the CD3/T-cell antigen receptor (TCR) and pathways of signal transduction in T lymphocytes from animals and patients with advanced malignancy.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CD3/T-	Cd3/t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
28	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1367
# text = Diminished expression of TCRzeta and p56(lck) that are associated with the TCR and reduced nuclear localization of RelA containing nuclear factor kappaB (NFkappaB) complexes have been noted.
1	Diminished	Diminished	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1368
# text = These defects have been described in T cells from patients with malignant melanoma, renal cell carcinoma (RCC), ovarian cancer, and colorectal cancer.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
13	melanoma	melanoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	ovarian	ovarian	ADJ	JJ	Degree=Pos	_	_	_	_
23	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	colorectal	colorectal	ADJ	JJ	Degree=Pos	_	_	_	_
27	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1369
# text = Preliminary observations also indicate possible correlation with clinical variables such as stage in selected instances.
1	Preliminary	Preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	variables	variable	NOUN	NNS	Number=Plur	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	selected	selected	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	instances	instance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1370
# text = To further characterize altered expression of TCRzeta, p56(lck), and impaired activation of NFkappaB, T lymphocytes were obtained from 65 patients with RCC, the majority of whom were receiving combination cytokine therapy [interleukin (IL)-2, IFN alpha-containing regimens] and 37 control individuals.
1	To	to	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	characterize	characterize	NOUN	NN	Number=Sing	_	_	_	_
4	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	65	65	NUM	CD	NumType=Card	_	_	_	_
26	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	whom	whom	PRON	WP	PronType=Rel	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
36	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
37	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
38	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
39	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	IFN	Ifn	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
51	regimens	regimen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	]	]	PUNCT	-RRB-	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	37	37	NUM	CD	NumType=Card	_	_	_	_
55	control	control	NOUN	NN	Number=Sing	_	_	_	_
56	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1371
# text = In 29 of these patients, levels of TCRzeta and p56(lck) were determined by Western blots of T-cell lysates and semiquantitated using densitometry.
1	In	in	ADP	IN	_	_	_	_	_
2	29	29	NUM	CD	NumType=Card	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
19	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	semiquantitated	semiquantitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
27	densitometry	densitometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1372
# text = Relative levels were then correlated with a series of clinical variables including response to therapy, performance status, survival, disease sites, age, and others.
1	Relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	series	series	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
11	variables	variable	NOUN	NNS	Number=Plur	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	performance	performance	NOUN	NN	Number=Sing	_	_	_	_
18	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1373
# text = In another group of 28 patients (three individuals from the first group), the frequency of abnormal NFkappaB activation was studied using electrophoretic mobility shift assays after activation of T cells with phorbol myristate acetate/ionomycin or anti-CD3 monoclonal antibody.
1	In	in	ADP	IN	_	_	_	_	_
2	another	another	DET	DT	_	_	_	_	_
3	group	group	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	28	28	NUM	CD	NumType=Card	_	_	_	_
6	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
20	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
25	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assays	assays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
36	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
37	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
42	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
43	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1374
# text = Changes in these signaling molecules during cytokine treatment were also investigated.
1	Changes	change	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1375
# text = TCRzeta and p56(lck) were detected in the peripheral blood T cells in 27 of 29 patients, and overall, reduced levels were noted visually in 12 of 29 (41%) and 13 of 29 (45%) individuals, respectively.
1	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	T	t	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	27	27	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	29	29	NUM	CD	NumType=Card	_	_	_	_
19	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	overall	overall	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	visually	visually	ADV	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	12	12	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	29	29	NUM	CD	NumType=Card	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	41	41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	13	13	NUM	CD	NumType=Card	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	29	29	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	45	45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1376
# text = When levels were semiquantitated using densitometry, significant decreases of TCRzeta (P = 0.029) and p56(lck) (P = 0.029) but not CD3epsilon (P = 0.131), compared with control levels, were found.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	semiquantitated	semiquantitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	densitometry	densitometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
9	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	P	P	SYM	NFP	_	_	_	_	_
14	=	=	SYM	SYM	_	_	_	_	_
15	0.029	0.029	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	P	p	NOUN	NN	Number=Sing	_	_	_	_
24	=	=	SYM	SYM	_	_	_	_	_
25	0.029	0.029	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	CD3epsilon	CD3epsilon	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	P	P	SYM	NFP	_	_	_	_	_
32	=	=	SYM	SYM	_	_	_	_	_
33	0.131	0.131	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	control	control	NOUN	NN	Number=Sing	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1377
# text = In patients treated with IL-2/IFN alpha-based therapy, relative levels of TCRzeta increased significantly (P = 0.002) on day 15 of cycle one compared with the baseline.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
3	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	significantly	significantly	ADV	RB	_	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	p	SYM	NFP	_	_	_	_	_
23	=	=	SYM	SYM	_	_	_	_	_
24	0.002	0.002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	day	day	NOUN	NN	Number=Sing	_	_	_	_
28	15	15	NUM	CD	NumType=Card	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
31	one	one	NUM	CD	NumType=Card	_	_	_	_
32	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1378
# text = Correlations of TCRzeta or p56(lck) levels with response or disease variables, except for lower TCRzeta levels (P < 0.001) in the presence of bone metastases, were not found.
1	Correlations	Correlation	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
14	variables	variable	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	except	except	ADP	IN	_	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
19	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	p	NOUN	NN	Number=Sing	_	_	_	_
23	<	<	PUNCT	-LRB-	_	_	_	_	_
24	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
31	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1379
# text = Abnormal NFkappaB activation after stimulation with phorbol myristate acetate/ionomycin and/or anti-CD3 monoclonal antibody was found in 59% of patients (17 of 28) and was not accounted for by the advanced age of the study cohort.
1	Abnormal	abnormal	PROPN	NNP	Number=Sing	_	_	_	_
2	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/ionomycin	/ionomycin	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	or	or	CCONJ	CC	_	_	_	_	_
14	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
15	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	17	17	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	28	28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	accounted	account	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
37	age	age	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	study	study	NOUN	NN	Number=Sing	_	_	_	_
41	cohort	cohort	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1380
# text = Activation of NFkappaB in peripheral blood T cells was inducible during cytokine therapy in four of six individuals who displayed impaired NFkappaB activity prior to therapy.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	four	four	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	six	six	NUM	CD	NumType=Card	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
19	who	who	PRON	WP	PronType=Rel	_	_	_	_
20	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
22	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1381
# text = Moreover, impaired activation of NFkappaB does not appear linked to a reduction of TCRzeta expression, because in five patients, normal TCRzeta levels were present although kappaB binding was not inducible.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	because	because	SCONJ	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	five	five	NUM	CD	NumType=Card	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	although	although	SCONJ	IN	_	_	_	_	_
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1382
# text = In the majority of patients with advanced RCC, peripheral blood T cells express TCRzeta and p56(lck), and in a subset, reduced levels of these TCRzeta associated molecules are seen that may increase during cytokine-based therapy.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
8	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
15	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	subset	subset	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	that	that	PRON	WDT	PronType=Dem	_	_	_	_
37	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
38	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
39	during	during	ADP	IN	_	_	_	_	_
40	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1383
# text = Abnormal activation of NFkappaB is also present in >50% of patients and may also revert to normal during IL-2/IFN alpha-based treatment.
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	>	>	SYM	NFP	_	_	_	_	SpaceAfter=No
10	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	normal	normal	VERB	VB	VerbForm=Inf	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1384
# text = This alteration in NFkappaB activation occurred in the presence of normal expression of TCRzeta-associated signaling elements.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1385
# text = The clinical significance of these findings remains unclear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
7	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1386
# text = Document 003002493 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002493	003002493	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1387
# text = Activation of protein kinase C and elevation of cAMP interact synergistically to raise c-Fos and AP-1 activity in Jurkat cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	C	c	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
11	synergistically	synergistically	ADV	RB	_	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	raise	raise	VERB	VB	VerbForm=Inf	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1388
# text = We have earlier found that in Jurkat cells activation of protein kinase C (PKC) enhances the cyclic adenosine monophosphate (cAMP) accumulation induced by adenosine receptor stimulation or activation of Gs.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	earlier	earlier	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
20	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
21	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Gs	g	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1389
# text = Here we have therefore examined the effect of the phorbol ester PMA (phorbol 12-myristate 13-acetate) which stimulates PKC and a combination of the adenosine receptor agonist NECA (5'-(N-ethyl)-carboxamido adenosine) and forskolin to raise cAMP, on the levels of c-Fos and Jun and on the binding and transcriptional activity of the transcription factor, activator protein-1 (AP-1).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	therefore	therefore	ADV	RB	_	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
18	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	adenosine	adenosine	ADJ	JJ	Degree=Pos	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
32	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
33	NECA	NECA	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	'-(	'-(	PUNCT	.	_	_	_	_	SpaceAfter=No
37	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	ethyl	ethyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	carboxamido	carboxamido	NOUN	NN	Number=Sing	_	_	_	_
42	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	forskolin	forskolin	VERB	VB	VerbForm=Inf	_	_	_	_
46	to	to	PART	TO	_	_	_	_	_
47	raise	raise	VERB	VB	VerbForm=Inf	_	_	_	_
48	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	on	on	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	Fos	Fo	PROPN	NNP	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	on	on	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
65	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
69	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	,	,	PUNCT	,	_	_	_	_	_
71	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
72	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
74	1	1	NUM	CD	NumType=Card	_	_	_	_
75	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
76	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
80	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1390
# text = PMA treatment caused a concentration- and time-dependent increase in both c-Fos and Jun immunoreactivity in contrast to cAMP elevation that had only a slight effect.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
18	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	cAMP	camp	VERB	VB	VerbForm=Inf	_	_	_	_
23	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1391
# text = Both PMA and the combination of NECA and forskolin acted together either to increase (c-Fos) or decrease (Jun) protein levels as well as increasing AP-1 binding, as judged by gel-shift assay, and AP-1 transcriptional activity.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NECA	NECA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	forskolin	forskolin	PROPN	NNP	Number=Sing	_	_	_	_
10	acted	act	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	together	together	ADV	RB	_	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	as	as	ADV	RB	_	_	_	_	_
28	well	well	ADV	RB	Degree=Pos	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	as	as	SCONJ	IN	_	_	_	_	_
37	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
42	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1392
# text = Furthermore there was a clear-cut synergy between the PKC stimulator and the cAMP elevating agents.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	_
2	there	there	PRON	EX	_	_	_	_	_
3	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cut	cut	ADJ	JJ	Degree=Pos	_	_	_	_
8	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
12	stimulator	stimulator	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
16	elevating	elevate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1393
# text = The results demonstrate that the simultaneous activation of PKC and elevation of cAMP leads to an enhanced AP-1 transcriptional activity in a T-leukemia cell line, suggesting that the previously observed interaction between the parallel signal transduction pathways may have functional consequences at the level of gene transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
14	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	previously	previously	ADV	RB	_	_	_	_	_
34	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	_
35	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
36	between	between	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
39	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
40	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
41	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
42	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
43	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
44	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
45	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
46	at	at	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	level	level	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1394
# text = Document 003002498 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002498	003002498	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1395
# text = c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1396
# text = The Zfh family of zinc finger/homeodomain proteins was first identified in Drosophila where it is required for differentiation of tissues such as the central nervous system and muscle.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Zfh	Zfh	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
6	finger	finger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	first	first	ADV	RB	_	_	_	_	_
12	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
15	where	where	ADV	WRB	PronType=Rel	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
27	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1397
# text = ZEB, a vertebrate homolog of Zfh-1, binds a subset of E boxes and blocks myogenesis through transcriptional repression of muscle genes.
1	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	vertebrate	vertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
5	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Zfh	Zfh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	E	e	NOUN	NN	Number=Sing	_	_	_	_
16	boxes	boxe	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
19	myogenesis	myogenesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1398
# text = We present evidence here that ZEB also has an important role in controlling hematopoietic gene transcription.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
14	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1399
# text = Two families of transcription factors that are required for normal hematopoiesis are c-Myb and Ets.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	families	family	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1400
# text = These factors act synergistically to activate transcription, and this synergy is required for transcription of at least several important hematopoietic genes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	synergistically	synergistically	ADV	RB	_	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	at	at	ADV	RB	_	_	_	_	_
18	least	least	ADV	RBS	Degree=Sup	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1401
# text = ZEB blocks the activity of c-Myb and Ets individually, but together the factors synergize to resist this repression.
1	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	_
2	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
11	individually	individually	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	together	together	ADV	RB	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	resist	resist	VERB	VB	VerbForm=Inf	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1402
# text = Such repression imposes a requirement for both c-Myb and Ets for transcriptional activity, providing one explanation for why synergy between these factors is important.
1	Such	such	ADJ	JJ	Degree=Pos	_	_	_	_
2	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
3	imposes	impose	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	both	both	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	why	why	ADV	WRB	PronType=Int	_	_	_	_
21	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1403
# text = The balance between repression by ZEB and transcriptional activation by c-Myb/Ets provides a flexible regulatory mechanism for controlling gene expression in hematopoietic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	Myb/	Myb/	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
14	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	flexible	flexible	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1404
# text = We demonstrate that one target of this positive/negative regulation in vivo is the alpha4 integrin, which play a key role in normal hematopoiesis and function of mature leukocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	target	target	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	alpha4	alpha4	NOUN	NN	Number=Sing	_	_	_	_
17	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
31	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1405
# text = Document 003002502 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002502	003002502	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1406
# text = Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	IkappaB	IkappaB	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	signalsome	signalsome	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
17	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1407
# text = The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
17	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1408
# text = This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	role	role	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
35	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
48	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
60	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
61	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	and	and	CCONJ	CC	_	_	_	_	_
65	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
66	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
69	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1409
# text = Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
1	Kinase	Kinase	ADJ	JJ	Degree=Pos	_	_	_	_
2	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	elicited	elicit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	lived	lived	ADJ	JJ	Degree=Pos	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IKK	IKK	NUM	CD	NumType=Card	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
22	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	alpha	alpha	ADV	RB	_	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	5	5	NUM	CD	NumType=Card	_	_	_	_
37	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1410
# text = In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	INTJ	UH	_	_	_	_	_
5	predominantly	predominantly	ADV	RB	_	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	slowly	slowly	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	30	30	NUM	CD	NumType=Card	_	_	_	_
19	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1411
# text = A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	_
10	point	point	NOUN	NN	Number=Sing	_	_	_	_
11	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
12	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	consisted	consist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	beta	beta	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1412
# text = The endogenous levels of the signalsome components were unaffected by stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	unaffected	unaffect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1413
# text = Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	association	association	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1414
# text = Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
9	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IkappaB	IkappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
18	disappearance	disappearance	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	reassembly	reassembly	ADV	RB	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	signalsome	signalsome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	IKK	Ikk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	_
37	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	associated	associate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1415
# text = NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
1	NIK	NIK	ADV	RB	_	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
3	not	not	PART	RB	_	_	_	_	_
4	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
5	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	functionally	functionally	ADV	RB	_	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	because	because	SCONJ	IN	_	_	_	_	_
21	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	effectively	effectively	ADV	RB	_	_	_	_	_
33	than	than	ADP	IN	_	_	_	_	_
34	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1416
# text = Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	stimulus	stimulus	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whereas	whereas	SCONJ	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1417
# text = The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	treat	treat	VERB	VB	VerbForm=Inf	_	_	_	_
20	sepsis-	sepsis-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1418
# text = Document 003002513 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002513	003002513	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1419
# text = Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner.
1	Extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
29	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1420
# text = When immunoglobulin
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1421
# text = (Ig) expressing B cells are fused with non-B cells, Ig expression is rapidly suppressed at the level of transcription, a phenomenon termed extinction.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	X	ADD	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	non	non	X	AFX	_	_	_	_	SpaceAfter=No
11	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
27	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1422
# text = Here we demonstrate that fusion of HeLa cells with either diploid or tetraploid B cells (Daudi) results in widespread extinction of several other B cell-encoded genes that are expressed in a B cell-specific manner.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	diploid	diploid	ADJ	JJ	Degree=Pos	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	tetraploid	tetraploid	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
22	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1423
# text = In contrast, expression of B cell-expressed genes that are not dependent on cell-specific controls is unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1424
# text = We show that the molecular mechanism(s) underlying Ig gene extinction can be explained, at least in part, by a lack of transcription factors that are essential for Ig gene transcription.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	underlying	underly	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ig	ig	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	SCONJ	IN	_	_	_	_	_
33	Ig	ig	VERB	VBG	VerbForm=Ger	_	_	_	_
34	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1425
# text = These transcription factors are either not produced due to block of transcription of their respective genes (Oct-2, OBF-1, PU.1), or are rendered inactive posttranslationally (NF-kappa B, E47).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	either	either	CCONJ	CC	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	due	due	ADP	IN	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	block	block	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	OBF	OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	rendered	render	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
32	posttranslationally	posttranslationally	ADV	RB	_	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	E47	E47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1426
# text = By isolating Daudi x
1	By	by	SCONJ	IN	_	_	_	_	_
2	isolating	isolate	VERB	VBG	VerbForm=Ger	_	_	_	_
3	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
4	x	x	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1427
# text = HeLa heterokaryons a few hours after fusion, we have studied the initial fate of two B cell-specific transcription factors involved in Ig gene transcription, Oct-2 and NF-kappa B.
1	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
2	heterokaryons	heterokaryon	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
5	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
6	after	after	ADP	IN	_	_	_	_	_
7	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
14	fate	fate	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
26	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1428
# text = This report provides the first demonstration that upon fusion with HeLa cells, the nuclear contents of B cell-expressed transcription factors are depleted within a few hours with kinetics that are as fast or faster than that of Ig gene extinction.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	report	report	NOUN	NN	Number=Sing	_	_	_	_
3	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	upon	upon	ADP	IN	_	_	_	_	_
9	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	contents	contents	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	within	within	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
29	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	as	as	ADV	RB	_	_	_	_	_
35	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	faster	faster	ADJ	JJR	Degree=Cmp	_	_	_	_
38	than	than	ADP	IN	_	_	_	_	_
39	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1429
# text = Thus, the extinguishing mechanism is effective very early after fusion.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	extinguishing	extinguishing	NOUN	NN	Number=Sing	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
8	very	very	ADV	RB	_	_	_	_	_
9	early	early	ADV	RB	Degree=Pos	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1430
# text = We suggest that extinction of Ig genes is part of a global mechanism that suppresses the differentiation program foreign to the HeLa phenotype.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	part	part	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	global	global	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	program	program	NOUN	NN	Number=Sing	_	_	_	_
19	foreign	foreign	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
23	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1431
# text = Document 003002514 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002514	003002514	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1432
# text = Sequential development of structural and functional alterations in T cells from tumor-bearing mice.
1	Sequential	Sequential	ADJ	JJ	Degree=Pos	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	bearing	bearing	VERB	VBG	VerbForm=Ger	_	_	_	_
15	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1433
# text = The TCR alpha beta or -gamma delta chains bind the peptide ligand, whereas the associated CD3 deltaepsilongamma and TCR zeta subunits couple the TCR to intracellular signal transduction components.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	ADP	IN	_	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
9	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
10	bind	bind	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
19	deltaepsilongamma	deltaepsilongamma	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
23	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
24	couple	couple	NOUN	NN	Number=Sing	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
30	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
31	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1434
# text = Recently, several groups have described marked alterations in signal transduction elements in T cells from cancer patients or in mice bearing tumor for a few weeks (>26 days).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
4	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
18	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
22	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
27	weeks	week	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	>26	>26	NUM	CD	NumType=Card	_	_	_	_
30	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1435
# text = The sequence in which these alterations develop is unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
7	develop	develop	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1436
# text = The aim of this study was to explore the kinetics of the development of alterations in signal transduction molecules (TCR zeta chain, NF kappaB family proteins, and tyrosine kinase p56(lck)) in mice bearing MC38 colon adenocarcinoma.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
40	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
41	MC38	MC38	NUM	CD	NumType=Card	_	_	_	_
42	colon	colon	NOUN	NN	Number=Sing	_	_	_	_
43	adenocarcinoma	adenocarcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1437
# text = The results demonstrate that alterations in NF kappaB family proteins, specifically the failure of p65 translocation to the nucleus, occur earlier and more frequently than the decrease in zeta-chain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	p65	p65	NUM	CD	NumType=Card	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	more	more	ADV	RBR	_	_	_	_	_
26	frequently	frequently	ADV	RB	_	_	_	_	_
27	than	than	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1438
# text = These defects are paralleled by an impaired ability to produce Th1 cytokines (IL-2 and IFN-gamma).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
8	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
11	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1439
# text = These initial changes are followed by the eventual loss of TCR zeta chain and p56(lck) and a marked decrease in cytotoxic function.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	eventual	eventual	ADJ	JJ	Degree=Pos	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
12	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1440
# text = An increased rate of lysosomal degradation is one of the mechanisms responsible for the loss of zeta-chain.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
6	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1441
# text = Document 003002520 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002520	003002520	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1442
# text = Thymocytes control the CD4 gene differently from mature T lymphocytes.
1	Thymocytes	Thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	differently	differently	ADV	RB	_	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1443
# text = We analyzed the activity of the enhancer, the promoter and the silencer of the human CD4 gene during T cell development using transgenic mice.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	_
23	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
24	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1444
# text = Immunofluorescence studies on thymic populations of mice carrying transgenes in various combinations of these regulatory DNA elements revealed that thymocytes control the CD4 gene in a different manner than mature peripheral T lymphocytes.
1	Immunofluorescence	Immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
5	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
9	transgenes	transgene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
12	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
31	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	NOUN	NN	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1445
# text = The 5'-positive regulatory unit, consisting of the promoter and the 5' enhancer, is already active at the CD4-CD8-double-negative (DN) stage of development.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	's	PUNCT	``	_	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	already	already	ADV	RB	_	_	_	_	_
21	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	CD4-CD8	CD4-CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	DN	DN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1446
# text = However, its activity becomes lower in the double-positive and a fraction of the CD4+ CD8int/- cell population, indicating that an additional enhancer, located in either the first or the third intron of the CD4 gene, is required for CD4 gene expression in this population.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	CD8int	CD8int	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	/-	/-	PUNCT	.	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	either	either	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
39	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
43	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
49	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
50	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
53	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1447
# text = The other studied regulatory element is the minimal CD4 silencer which inhibits CD4 gene expression in peripheral CD8 T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
10	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1448
# text = This silencer is inactive in the most immature DN thymocytes, which probably use a distinct silencer mechanism to down-regulate CD4 gene expression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	most	most	ADV	RBS	_	_	_	_	_
8	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
9	DN	Dn	NOUN	NN	Number=Sing	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	probably	probably	ADV	RB	_	_	_	_	_
14	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
23	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1449
# text = Unexpectedly, the CD4 silencer is also active in CD4+ CD8int/- cells of the thymus, implying that an anti-silencer may be required to resume CD4 expression in this cell population.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	+	+	SYM	SYM	_	_	_	_	_
12	CD8int	CD8int	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/-	/-	PUNCT	.	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	implying	imply	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	anti-silencer	anti-silencer	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	resume	resume	VERB	VB	VerbForm=Inf	_	_	_	_
28	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1450
# text = Altogether, the CD4 gene is regulated by several positive and negative regulatory mechanisms which come into play in a developmentally coordinated manner.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	come	come	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	play	play	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	developmentally	developmentally	ADV	RB	_	_	_	_	_
22	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1451
# text = Document 003002530 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002530	003002530	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1452
# text = Globin gene switching.
1	Globin	Globin	PROPN	NNP	Number=Sing	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	switching	switching	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1453
# text = In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	program	program	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1454
# text = To characterize the protein-DNA interactions important for the developmental control of the human beta-globin locus, we analyzed by in vivo dimethyl sulfate footprinting erythroid cells expressing either the fetal or the adult globin developmental program.
1	To	to	PART	TO	_	_	_	_	_
2	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
26	dimethyl	dimethyl	NOUN	NN	Number=Sing	_	_	_	_
27	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
28	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
29	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
32	either	either	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
38	globin	globin	ADP	IN	_	_	_	_	_
39	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
40	program	program	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1455
# text = In the locus control region (LCR) of the beta-globin locus, in vivo footprints on NF-E2 (or AP-1) and GATA-1 motifs remained the same regardless of whether the fetal or the adult globin genes are expressed.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
4	control	control	NOUN	NN	Number=Sing	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
18	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-E2	-E2	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	or	or	CCONJ	CC	_	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	X	LS	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
33	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
36	regardless	regardless	ADV	RB	_	_	_	_	_
37	of	of	SCONJ	IN	_	_	_	_	_
38	whether	whether	SCONJ	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
44	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
45	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1456
# text = In contrast, in vivo footprints on GT (CACCC) motifs differed between the cells expressing the fetal or the adult globin program.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
6	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	GT	GT	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	CACCC	CACCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
13	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
24	program	program	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1457
# text = In promoter regions, the actively transcribed genes demonstrated extensive and consistent footprints over the canonical elements, such as CACCC and CCAAT motifs.
1	In	in	ADP	IN	_	_	_	_	_
2	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
3	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	actively	actively	ADV	RB	_	_	_	_	_
7	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
13	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
14	over	over	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	canonical	canonical	ADJ	JJ	Degree=Pos	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	CACCC	CACCC	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	CCAAT	Ccaat	ADJ	JJ	Degree=Pos	_	_	_	_
24	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1458
# text = The adult globin expressing cells displayed more extensive footprints than the fetal globin expressing cells in the 3' regulatory sequences of both the Agamma- and the beta-globin genes, suggesting a role of these 3' elements in beta-globin gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
3	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
4	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
9	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
10	than	than	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Agamma	Agamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
39	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	'	'	PUNCT	''	_	_	_	_	_
41	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1459
# text = Our results suggest that the bulk of protein-DNA interactions that underlies the developmental control of globin genes takes place in the gamma- and beta-globin gene promoters, and that GT motifs of the beta-globin locus LCR may play a role in the developmental regulation of human beta-globin gene expression, perhaps by increasing the probability of interaction of the LCR holocomplex with the fetal or the adult globin gene.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	bulk	bulk	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	underlies	underly	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	takes	take	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	place	place	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	GT	Gt	NOUN	NN	Number=Sing	_	_	_	_
36	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
42	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
43	LCR	Lcr	PROPN	NNP	Number=Sing	_	_	_	_
44	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
45	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	role	role	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
51	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
54	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
57	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
58	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	perhaps	perhaps	ADV	RB	_	_	_	_	_
61	by	by	SCONJ	IN	_	_	_	_	_
62	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	probability	probability	NOUN	NN	Number=Sing	_	_	_	_
65	of	of	ADP	IN	_	_	_	_	_
66	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
69	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	_
70	holocomplex	holocomplex	NOUN	NN	Number=Sing	_	_	_	_
71	with	with	ADP	IN	_	_	_	_	_
72	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
73	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
74	or	or	CCONJ	CC	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
77	globin	globin	ADP	IN	_	_	_	_	_
78	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1460
# text = Document 003002536 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002536	003002536	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1461
# text = Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	4E	4e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	BP2	Bp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
16	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1462
# text = Human myeloid differentiation is accompanied by a decrease in cell proliferation.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1463
# text = Because the translation rate is an important determinant of cell proliferation, we have investigated translation initiation during human myeloid cell differentiation using the HL-60 promyelocytic leukemia cell line and the U-937 monoblastic cell line.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
8	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
17	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	60	60	NUM	CD	NumType=Card	_	_	_	_
28	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
36	937	937	NUM	CD	NumType=Card	_	_	_	_
37	monoblastic	monoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1464
# text = A decrease in the translation rate is observed when the cells are induced to differentiate along the monocytic/macrophage pathway or along the granulocytic pathway.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
6	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
16	along	along	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	along	along	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1465
# text = The inhibition in protein synthesis correlates with specific regulation of two repressors of translation initiation, 4E-BP1 and 4E-BP2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
15	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	BP1	Bp1	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	BP2	Bp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1466
# text = Induction of HL-60 and U-937 cell differentiation into monocytes/macrophages by IFN-gamma or PMA results in a dephosphorylation and consequent activation of 4E-BP1.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
22	results	result	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1467
# text = Dephosphorylation of 4E-BP1 was also observed when U-937 cells were induced to differentiate into monocytes/macrophages following treatment with retinoic acid or DMSO.
1	Dephosphorylation	Dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	937	937	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
22	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
26	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1468
# text = In contrast, treatment of HL-60 cells with retinoic acid or DMSO, which results in a granulocytic differentiation of these cells, decreases 4E-BP1 amount without affecting its phosphorylation and strongly increases 4E-BP2 amount.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	60	60	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	DMSO	Dmso	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	DET	WDT	PronType=Int	_	_	_	_
17	results	result	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	4E	4e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	BP1	Bp1	PROPN	NNP	Number=Sing	_	_	_	_
30	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
31	without	without	SCONJ	IN	_	_	_	_	_
32	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	strongly	strongly	ADV	RB	_	_	_	_	_
37	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	BP2	Bp2	NUM	CD	NumType=Card	_	_	_	_
41	amount	amount	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1469
# text = Taken together, these data provide evidence for differential regulation of the translational machinery during human myeloid differentiation, specific to the monocytic/macrophage pathway or to the granulocytic pathway.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
14	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1470
# text = Document 003002537 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002537	003002537	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1471
# text = Regulatory effects of interleukin-11 during acute lung inflammatory injury.
1	Regulatory	Regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	11	11	NUM	CD	NumType=Card	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
9	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1472
# text = The role of interleukin-11 (IL-11) was evaluated in the IgG immune complex model of acute lung injury in rats.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-11	-11	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
18	model	model	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
21	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
22	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	rats	rat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1473
# text = IL-11 mRNA and protein were both up-regulated during the course of this inflammatory response.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	11	11	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	both	both	ADV	RB	_	_	_	_	_
9	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	course	course	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1474
# text = Exogenously administered IL-11 substantially reduced, in a dose-dependent manner, the intrapulmonary accumulation of neutrophils and the lung vascular leak of albumin.
1	Exogenously	Exogenously	ADV	RB	_	_	_	_	_
2	administered	administer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	11	11	NUM	CD	NumType=Card	_	_	_	_
6	substantially	substantially	ADV	RB	_	_	_	_	_
7	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	intrapulmonary	intrapulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
18	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
24	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
25	leak	leak	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	albumin	albumin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1475
# text = These in vivo anti-inflammatory effects of IL-11 were associated with reduced NF-kappaB activation in lung, reduced levels of tumor necrosis factor alpha (TNF-alpha) in bronchoalveolar lavage (BAL) fluids, and diminished up-regulation of lung vascular ICAM-1.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
4	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	11	11	NUM	CD	NumType=Card	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	bronchoalveolar	bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
35	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	BAL	Bal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	fluids	fluid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
48	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
49	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1476
# text = It is interesting that IL-11 did not affect BAL fluid content of the CXC chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-inducible neutrophil chemoattractant (CINC); the presence of IL-11 did not affect these chemokines.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	interesting	interesting	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	11	11	NUM	CD	NumType=Card	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
11	BAL	Bal	ADJ	JJ	Degree=Pos	_	_	_	_
12	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
13	content	content	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CXC	CXC	NOUN	NN	Number=Sing	_	_	_	_
17	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	_
20	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
31	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
33	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	CINC	CINC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	11	11	NUM	CD	NumType=Card	_	_	_	_
44	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
47	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
48	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1477
# text = However, BAL content of C5a was reduced by IL-11.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	BAL	Bal	ADJ	NNP	Number=Sing	_	_	_	_
4	content	content	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1478
# text = These data indicate that IL-11 is a regulatory cytokine in the lung and that, like other members of this family, its anti-inflammatory properties appear to be linked to its suppression of NF-kappaB activation, diminished production of TNF-alpha, and reduced up-regulation of lung vascular ICAM-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	11	11	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	like	like	ADP	IN	_	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
28	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	production	production	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
55	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
56	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1479
# text = Document 003002
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002	003002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No

# sent_id = 1480
# text = 544 ends.
1	544	544	NUM	CD	NumType=Card	_	_	_	_
2	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1481
# text = v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII.
1	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	erbA	erbA	NOUN	NN	Number=Sing	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	extinguish	extinguish	VERB	VB	VerbForm=Inf	_	_	_	_
8	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	erbA	erba	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
20	target	target	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	CAII	caii	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1482
# text = The v-erbA oncoprotein represents a retrovirus-transduced oncogenic version of the thyroid hormone (T3/T4) receptor c-erbA (type alpha).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
4	oncoprotein	oncoprotein	ADV	RB	_	_	_	_	_
5	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	version	version	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
15	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	T3/	T3/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	T4	T4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
22	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	type	type	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1483
# text = It contributes to virus-induced erythroleukemia by efficiently arresting differentiation of red cell progenitors and by suppressing transcription of erythrocyte-specific genes.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	virus	virus	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	efficiently	efficiently	ADV	RB	_	_	_	_	_
10	arresting	arreste	VERB	VBG	VerbForm=Ger	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	erythrocyte-specific	erythrocyte-specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1484
# text = Here, we show that v-erbA and c-erbA bind directly to sequences within the promoter of the erythrocyte-specific carbonic anhydrase II (CAII), a gene whose transcription is efficiently suppressed by v-erbA.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	erbA	erbA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
12	directly	directly	ADV	RB	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	erythrocyte-	erythrocyte-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	carbonic	carbonic	NOUN	NN	Number=Sing	_	_	_	_
23	anhydrase	anhydrase	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CAII	Caii	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	efficiently	efficiently	ADV	RB	_	_	_	_	_
35	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1485
# text = This erbA-binding site confers thyroid hormone responsiveness to a heterologous promoter in transient expression experiments and is a target for efficient down-regulation of CAII transcription by the v-erbA oncoprotein.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	erbA-	erbA-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
6	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
7	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
8	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	target	target	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
23	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	CAII	Caii	PROPN	NNP	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
32	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
33	oncoprotein	oncoprotein	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1486
# text = In stably transformed erythroblasts coexpressing the v-erbA oncoprotein and the c-erbA/T3 receptor at an approximately equimolar ratio, c-erbA activity is dominant over v-erbA.
1	In	in	ADP	IN	_	_	_	_	_
2	stably	stably	ADV	RB	_	_	_	_	_
3	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
5	coexpressing	coexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
9	oncoprotein	oncoprotein	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	erbA/T3	erbA/T3	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	equimolar	equimolar	ADJ	JJ	Degree=Pos	_	_	_	_
19	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	erbA	erbA	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
26	over	over	ADP	IN	_	_	_	_	_
27	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	erbA.	erbA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1487
# text = T3 efficiently induced erythroid differentiation in these cells, thus overcoming the v-erbA-mediated differentiation arrest.
1	T3	T3	NUM	CD	NumType=Card	_	_	_	_
2	efficiently	efficiently	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	thus	thus	ADV	RB	_	_	_	_	_
11	overcoming	overcom	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1488
# text = Likewise, T3 activated CAII transcription as well as transient expression of a T3-responsive reporter gene containing the CAII-specific erbA-binding site.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	T3	T3	NUM	CD	NumType=Card	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	CAII	Caii	NUM	CD	NumType=Card	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	T3	T3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CAII	CAII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	erbA-	erba-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1489
# text = The c-erbA-dependent activation of this CAII reporter construct could only be suppressed by very high amounts of v-erbA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erbA-dependent	erbA-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	CAII	CAII	ADJ	JJ	Degree=Pos	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	very	very	ADV	RB	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1490
# text = Our results suggest that overexpression of v-erbA is required for its function as an oncoprotein.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	v-	v-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1491
# text = Document 003002548 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002548	003002548	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1492
# text = Differential induction of the NF-AT complex during restimulation and the induction of T-cell anergy.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	ADJ	JJ	Degree=Pos	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	restimulation	restimulation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1493
# text = Stimulation of human CD4+ T-cell clones through the T-cell receptor (TcR) by high doses of specific peptide results in the induction of a long-lived state of nonresponsiveness that has been called anergy.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
23	results	result	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	lived	live	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	state	state	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	nonresponsiveness	nonresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	called	call	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1494
# text = During the induction of anergy, T cells are phenotypically similar to cells responding to an immunogenic stimulus.
1	During	during	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	T	t	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	phenotypically	phenotypically	ADV	RB	_	_	_	_	_
11	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1495
# text = The amount of TcR at the cell surface is downmodulated, whereas the CD2 and CD25 receptors are increased.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	downmodulated	downmodulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CD25	Cd25	NUM	CD	NumType=Card	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1496
# text = When restimulated, however, anergic T cells fail to up-regulate transcription of the IL-2 gene and in consequence do not produce IL-2.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	restimulated	restimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
24	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1497
# text = In this study, we have compared the ability of various transcription factors to bind to their appropriate site on DNA.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1498
# text = Factors were isolated from the nuclei of T cells that were in the induction phase of anergy or were undergoing activation.
1	Factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	undergoing	undergoing	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1499
# text = The pattern of binding activity in restimulated T cells is consistent with the pattern that has previously been shown to regulate T-cell-specific expression of the IL-2 and the beta chain of the TcR genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	SCONJ	IN	_	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	restimulated	restimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	previously	previously	ADV	RB	_	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
22	T-cell	T-cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	TcR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1500
# text = The measured binding to a TCF-1 site is the same in the nuclei of resting, activated, and anergized cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	resting	resting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	anergized	anergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1501
# text = The inducible factors NK-kappa B, beta E2, CD28RC, and AP-1 are not expressed in resting cells and are twofold lower in anergized as compared with activated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	CD28RC	CD28RC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	twofold	twofold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	anergized	anergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1502
# text = In contrast, anergic T cells express approximately eightfold lower amounts of NF-AT, a member of the class of inducible factors that regulates IL-2 gene transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	approximately	approximately	ADV	RB	_	_	_	_	_
9	eightfold	eightfold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
11	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	member	member	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	class	class	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1503
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1504
# text = Document 003002549 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002549	003002549	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1505
# text = The p53 paradox in the pathogenesis of tumor progression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
3	paradox	paradox	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1506
# text = Recent evidence suggests that the p53 molecule appears in two different forms: the mutant p53 that stimulates tumor progression, and wild type p53 that inhibits tumor progression.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
12	forms	form	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
16	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	_
24	type	type	NOUN	NN	Number=Sing	_	_	_	_
25	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1507
# text = In addition, it has been established that tumor necrosis factor-alpha (TNF-alpha) can activate the expression of wild type p53 in concert with the nuclear transcription factor, NF-kappa B.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	_
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1508
# text = Both TNF-alpha and NF-kappa B are also involved in the stimulation of the pathway that leads to the expression of major histocompatibility complex (MHC) class I molecules and, hence, antigen presentation to the T cells.
1	Both	both	DET	DT	_	_	_	_	_
2	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
26	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	class	class	NOUN	NN	Number=Sing	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
39	presentation	presentation	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1509
# text = In this paper we shall advance the hypothesis that: (i) TNF-alpha indirectly controls immune surveillance; and (ii) TNF-alpha controls DNA repair and tumor suppression through the regulation of wild type p53.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	shall	shall	AUX	MD	VerbForm=Fin	_	_	_	_
6	advance	advance	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	i	i	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	indirectly	indirectly	ADV	RB	_	_	_	_	_
18	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	surveillance	surveillance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	repair	repair	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
34	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
35	through	through	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	_
40	type	type	NOUN	NN	Number=Sing	_	_	_	_
41	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1510
# text = Thus, it is hypothesized that elevated TNF-alpha is primarily responsible for promoting tumor progression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	hypothesized	hypothesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	primarily	primarily	ADV	RB	_	_	_	_	_
13	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	SCONJ	IN	_	_	_	_	_
15	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
16	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
17	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1511
# text = Document 003002554 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002554	003002554	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1512
# text = Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside-binding lectin, galectin-3.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphotropic	lymphotropic	ADJ	JJ	Degree=Pos	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	galactoside-binding	galactoside-binding	NOUN	NN	Number=Sing	_	_	_	_
19	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1513
# text = Animal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates.
1	Animal	animal	ADJ	JJ	Degree=Pos	_	_	_	_
2	lectins	lectin	NOUN	NNS	Number=Plur	_	_	_	_
3	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
11	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	glycoconjugates	glycoconjugate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1514
# text = Galectin-3 is a beta-galactoside-binding lectin previously designated as epsilon BP (IgE-binding protein), CBP35, Mac-2, L-29, and L-34, and its expression has been associated with various physiological and pathological processes, including cell growth, tumor transformation, and metastasis.
1	Galectin	Galectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	galactoside	galactoside	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
12	previously	previously	ADV	RB	_	_	_	_	_
13	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	epsilon	epsilon	ADP	IN	_	_	_	_	_
16	BP	BP	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CBP35	CBP35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	L	L	SYM	$	_	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	29	29	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	L	l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-34	-34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
39	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
46	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
49	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
52	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
53	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
56	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	metastasis	metastasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1515
# text = Galectin-3 is widely distributed in various tissues and cell types and is expressed in many leukocytes, with the notable exception of B and T lymphocytes.
1	Galectin	Galectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	widely	widely	ADV	RB	_	_	_	_	_
6	distributed	distribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
18	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	notable	notable	ADJ	JJ	Degree=Pos	_	_	_	_
23	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1516
# text = We now report that galectin-3 is abundantly expressed in a number of human T lymphotropic virus (HTLV)-I-infected human T cell lines, including F6T, HUT 102, K3T, MT-2, and SLB-I, but is not expressed in non-HTLV-I-infected T cell lines such as Jurkat, CEM, and MOLT-4.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	abundantly	abundantly	ADV	RB	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	number	number	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphotropic	lymphotropic	ADJ	JJ	Degree=Pos	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	T	t	NOUN	NN	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	F6T	F6T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	HUT	Hut	PROPN	NNP	Number=Sing	_	_	_	_
35	102	102	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	K3T	K3T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	MT	Mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	SLB	SLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	but	but	CCONJ	CC	_	_	_	_	_
49	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	not	not	PART	RB	_	_	_	_	_
51	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	non-HTLV	non-HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
55	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
56	-infected	-infect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
57	T	t	PROPN	NNP	Number=Sing	_	_	_	_
58	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
59	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
60	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
61	as	as	ADP	IN	_	_	_	_	_
62	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	,	,	PUNCT	,	_	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	MOLT	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1517
# text = In addition, the galectin-3 level was markedly increased in human thymocytes after infection with HTLV-I as compared with uninfected thymocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	markedly	markedly	ADV	RB	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	as	as	AUX	VBP	Mood=Ind|Tense=Pres|Typo=Yes|VerbForm=Fin	_	_	_	_
22	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	uninfected	uninfect	ADJ	JJ	Degree=Pos	_	_	_	_
25	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1518
# text = The up-regulation of galectin-3 expression appeared to correlate well with HTLV-I gene expression, as undetectable or very low levels of galectin-3 were found in the S1T and ATL-1K cell lines, which are nonproductively infected with HTLV-I.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	very	very	ADV	RB	_	_	_	_	_
25	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-3	-3	NUM	CD	NumType=Card	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	S1T	S1T	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	ATL	ATL	ADV	RB	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	K	k	NUM	CD	NumType=Card	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	which	which	PRON	WDT	PronType=Rel	_	_	_	_
44	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	nonproductively	nonproductively	ADV	RB	_	_	_	_	_
46	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	with	with	ADP	IN	_	_	_	_	_
48	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
50	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1519
# text = In co-transfection experiments, the galectin-3 promoter was significantly up-regulated by expression vectors encoding the 40-kd Tax protein, a potent transactivator in HTLV-I.
1	In	in	ADP	IN	_	_	_	_	_
2	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
18	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
23	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
28	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1520
# text = Analysis of various Tax mutants suggested that galectin-3 promoter induction is dependent on activation of the cyclic-AMP-responsive element binding protein/activation transcription factor family of transcription factors and, to a lesser extent, nuclear factor-kappa B/Rel induction.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cyclic	cyclic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	protein/	proteinith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
39	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
47	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
48	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1521
# text = Transfection of human promonocytic U-937 cells with an HTLV-I Tax expression vector induced galectin-3 expression in this cell line.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	937	937	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1522
# text = Functionally, galectin-3 was shown to activate interleukin-2 production in Jurkat T cells.
1	Functionally	functionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1523
# text = Together, these findings raise the possibility that HTLV-I Tax production induces the transcription and subsequent synthesis and secretion of galectin-3, which in turn may further activate these T cells and contribute to the altered properties of cell growth found in adult T cell leukemia induced by HTLV-I.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	raise	raise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	HTLV	HTLV	VERB	VBP	Abbr=Yes|Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
19	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	further	further	ADV	RB	_	_	_	_	_
31	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
44	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
47	T	T	PROPN	NNP	Number=Sing	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
50	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1524
# text = Document 003002562 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002	003002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	562	562	NUM	CD	NumType=Card	_	_	_	_
4	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1525
# text = Initiation binding repressor, a factor that binds to the transcription initiation site of the histone h5 gene, is a glycosylated member of a family of cell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735]
1	Initiation	Initiation	NOUN	NN	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
17	h5	h5	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	glycosylated	glycosylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	member	member	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
30	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
31	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	corrected	correct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
33	]	]	PUNCT	-RRB-	_	_	_	_	_
34	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
37	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	Mol	Mol	PROPN	NNP	Number=Sing	_	_	_	_
40	Cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
41	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
42	1996	1996	NUM	CD	NumType=Card	_	_	_	_
43	Feb;16	Feb;16	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	2)	2)	SYM	NFP	_	_	_	_	SpaceAfter=No
46	:735	:735	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1526
# text = Initiation binding repressor [corrected] (IBR) is a chicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the transcription initiation site of the histone h5 gene, repressing its transcription.
1	Initiation	Initiation	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
4	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	corrected	correct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
6	]	]	PUNCT	-RRB-	_	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	chicken	chicken	NOUN	NN	Number=Sing	_	_	_	_
13	erythrocyte	erythrocyte	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
17	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
18	mass	mass	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	70	70	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	73	73	NUM	CD	NumType=Card	_	_	_	_
23	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
30	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
38	h5	h5	NUM	CD	NumType=Card	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	repressing	represse	VERB	VBG	VerbForm=Ger	_	_	_	_
42	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1527
# text = A variety of other cells, including transformed erythroid precursors, do not have IBR but a factor referred to as IBF (68 to 70 kDa) that recognizes the same IBR sites.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
8	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
10	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
15	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	IBF	IBF	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	68	68	NUM	CD	NumType=Card	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	70	70	NUM	CD	NumType=Card	_	_	_	_
27	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
33	IBR	Ibr	NOUN	NN	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1528
# text = We have cloned the IBR cDNA and studied the relationship of IBR and IBF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	_
6	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IBF	IBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1529
# text = IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors P3A2 and erected wing gene product (EWG).
1	IBR	Ibr	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	503	503	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	99.0	99.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	recently	recently	ADV	RB	_	_	_	_	_
21	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	NRF	NRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Pal	pal	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	highly	highly	ADV	RB	_	_	_	_	_
33	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	invertebrate	invertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
39	P3	P3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	A2	A2	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	erected	erect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	wing	w	NOUN	NN	Number=Sing	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
45	product	product	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	EWG	EWG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1530
# text = We present evidence that IBR and IBF are most likely identical proteins, differing in their degree of glycosylation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IBF	IBF	PROPN	NNP	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	most	most	ADV	RBS	_	_	_	_	_
10	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
11	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	differing	differ	VERB	VBG	VerbForm=Ger	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glycosylation	glycosylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1531
# text = We have analyzed several molecular aspects of IBR/F and shown that the factor associates as stable homodimers and that the dimer is the relevant DNA-binding species.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IBR/	IBR/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	F	F	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
18	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1532
# text = The evolutionarily conserved N-terminal half of IBR/F harbors the DNA-binding/dimerization domain (outer limits, 127 to 283), one or several casein kinase II sites (37 to 67), and a bipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	evolutionarily	evolutionarily	ADV	RB	Degree=Pos	_	_	_	_
3	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
6	half	half	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IBR/	Ibr/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	F	F	PROPN	NNP	Number=Sing	_	_	_	_
10	harbors	harbor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
15	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	outer	outer	ADJ	JJ	Degree=Pos	_	_	_	_
20	limits	limit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	127	127	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	283	283	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	one	one	NUM	CD	NumType=Card	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
30	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
31	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	37	37	NUM	CD	NumType=Card	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	67	67	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	bipartite	bipartite	ADJ	JJ	Degree=Pos	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
45	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	89	89	NUM	CD	NumType=Card	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	106	106	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	which	which	PRON	WDT	PronType=Rel	_	_	_	_
52	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	to	to	PART	TO	_	_	_	_	_
54	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
55	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
56	for	for	ADP	IN	_	_	_	_	_
57	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
58	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1533
# text = Binding site selection revealed that the alternating RCGCRYGCGY consensus constitutes high-affinity IBR/F binding sites and that the direct-repeat palindrome TGCGCATGCGCA is the optimal site.
1	Binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	alternating	alternate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	RCGCRYGCGY	Rcgcrygcgy	NOUN	NN	Number=Sing	_	_	_	_
9	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
10	constitutes	constitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
14	IBR/	IBR/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	F	f	SCONJ	IN	_	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	repeat	repeat	ADJ	JJ	Degree=Pos	_	_	_	_
24	palindrome	palindrome	NOUN	NN	Number=Sing	_	_	_	_
25	TGCGCATGCGCA	TGCGCATGCGCa	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1534
# text = A survey of genes potentially regulated by this family of factors primarily revealed genes involved in growth-related metabolism.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	survey	survey	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	potentially	potentially	ADV	RB	_	_	_	_	_
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	primarily	primarily	ADV	RB	_	_	_	_	_
13	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1535
# text = Document 003002564 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002	003002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	564	564	NUM	CD	NumType=Card	_	_	_	_
4	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1536
# text = Apoptosis signaling pathways in normal T cells: differential activity of Bcl-2 and IL-1beta-converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity.
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	_
2	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	converting	convert	VERB	VBG	VerbForm=Ger	_	_	_	_
22	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
25	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1537
# text = Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells.
1	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1538
# text = Restimulation of T cell blasts up-regulates Fas and Fas ligand expression, with subsequent interaction leading to cell death.
1	Restimulation	Restimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
5	blasts	blast	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	_
9	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
12	ligand	ligand	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
21	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1539
# text = Overexpression of Bcl-2 in tumor cells blocks apoptosis induced by many stimuli, but inhibition of Fas-mediated killing has not been consistently observed.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	tumor	tumor	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
14	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	killing	killing	NOUN	NN	Number=Sing	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	consistently	consistently	ADV	RB	_	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1540
# text = To examine the behavior of Bcl-2 in normal cells, T cell blasts were transiently transfected with Bcl-2 and related gene products to determine the effect on apoptotic signaling.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	transiently	transiently	ADV	RB	_	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
25	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	products	product	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
33	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1541
# text = Transient overexpression of Bcl-2 in mouse and human T cell blasts did not block Fas-mediated apoptosis, whereas etoposide- and glucocorticoid-induced cytotoxicity was potently inhibited.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
17	Fas-	Fas-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	wherea	ADV	RB	_	_	_	_	_
22	etoposide	etoposide	ADV	RB	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	potently	potently	ADV	RB	_	_	_	_	_
30	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1542
# text = Expression of Bcl-xL and adenovirus E1B 19K did not interfere with anti-Fas killing.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	xL	xL	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	adenovirus	adenovirus	PROPN	NNP	Number=Sing	_	_	_	_
8	E1B	E1B	PROPN	NNP	Number=Sing	_	_	_	_
9	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	K	k	NUM	CD	NumType=Card	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	anti	anti	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-Fas	-Fas	SCONJ	IN	_	_	_	_	_
17	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1543
# text = In contrast, interleukin-1beta-converting enzyme family protease inhibitors Ac-DEVD-CHO and CrmA blocked Fas-mediated apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	converting	converte	VERB	VBG	VerbForm=Ger	_	_	_	_
10	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
14	Ac-	Ac-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	DEVD	DEVD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CHO	Cho	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CrmA	CrmA	PROPN	NNP	Number=Sing	_	_	_	_
20	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1544
# text = These results suggest that peripheral T cells use distinct apoptosis signaling pathways with differential sensitivity to Bcl-2 and interleukin-1beta-converting enzyme family protease inhibitors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
15	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	converting	convert	VERB	VBG	VerbForm=Ger	_	_	_	_
26	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	_
28	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
29	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1545
# text = Since T cells normally express Bcl-2 and Bcl-xL following activation, their inability to block Fas-mediated apoptosis may allow for the elimination of self-reactive cells and the appropriate regulation of immune responses.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	normally	normally	ADV	RB	_	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	xL	xL	PROPN	NNP	Number=Sing	_	_	_	_
13	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
20	Fas-	Fas-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	elimination	elimination	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
39	responses	respons	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1546
# text = Document 003002565 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002565	003002565	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1547
# text = Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
12	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	myelomonoblastic	myelomonoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1548
# text = The effects of human immunodeficiency virus 1 (HIV-1) infection on cellular differentiation and NF-kappa B DNA binding activity have been investigated in a new model of myeloid differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
31	model	model	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1549
# text = PLB-985 cells represent a bipotential myelomonoblastic cell population capable of either granulocytic or monocytic differentiation after induction with appropriate inducers.
1	PLB	Plb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	985	985	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	bipotential	bipotential	ADJ	JJ	Degree=Pos	_	_	_	_
8	myelomonoblastic	myelomonoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	population	population	NOUN	NN	Number=Sing	_	_	_	_
11	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
22	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1550
# text = By virtue of the presence of CD4 on the cell surface, PLB-985 cells were chronically infected with HIV-1 strain IIIB.
1	By	by	ADP	IN	_	_	_	_	_
2	virtue	virtue	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PLB	Plb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	985	985	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	chronically	chronically	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
25	IIIB	Iiib	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1551
# text = PLB-IIIB cells clearly possessed a more monocytic phenotype than the parental myeloblasts, as determined by differential staining, increased expression of the myeloid-specific surface markers, and transcription of the c-fms proto-oncogene.
1	PLB	Plb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	IIIB	Iiib	NOUN	NN	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	clearly	clearly	ADV	RB	_	_	_	_	_
6	possessed	possess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	more	more	ADV	RBR	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
14	myeloblasts	myeloblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
20	staining	staining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
30	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	fms	fm	NOUN	NNS	Number=Plur	_	_	_	_
38	proto	proto	PART	TO	_	_	_	_	SpaceAfter=No
39	-oncogene	-oncogene	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1552
# text = NF-kappa B binding activity was inducible by tumor necrosis factor and phorbol myristate acetate in PLB-985.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
16	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	PLB	PLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	985	985	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1553
# text = However, in PLB-IIIB cells, constitutive expression of a novel NF-kappa B complex was detected, composed of proteins ranging between 70 and 110 kD.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	PLB	PLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IIIB	IIIB	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	ranging	range	VERB	VBG	VerbForm=Ger	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	70	70	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	110	110	NUM	CD	NumType=Card	_	_	_	_
30	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1554
# text = These proteins interacted specifically with the symmetric NF-kappa B site from the interferon beta (IFN-beta) promoter.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	specifically	specifically	ADV	RB	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	symmetric	symmetric	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1555
# text = Mutations affecting the 5' guanine residues of the kappa B site were unable to compete for these NF-kappa B-related proteins.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	affecting	affecte	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	'	'	PUNCT	``	_	_	_	_	_
6	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
7	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1556
# text = Inducibility of endogenous IFN-beta and IFN-alpha RNA was also increased in PLB-IIIB cells.
1	Inducibility	Inducibility	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	PLB	PLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	IIIB	Iiib	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1557
# text = These studies indicate that HIV-1 infection of myelomonoblastic cells may select for a more mature monocytic phenotype and that unique subunit associations of NF-kappa B DNA binding proteins may contribute to differential NF-kappa B-mediated gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	myelomonoblastic	myelomonoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	select	select	VERB	VB	VerbForm=Inf	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	more	more	ADV	RBR	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
23	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
24	associations	association	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	differential	differential	VERB	VB	VerbForm=Inf	_	_	_	_
37	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1558
# text = Document 003002567 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002567	003002567	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1559
# text = NF-kappa B activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	stably	stably	ADV	RB	_	_	_	_	_
10	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphotropic	lymphotropic	ADJ	JJ	Degree=Pos	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1560
# text = The effect of constitutive Tax expression on the interaction of NF-kappa B with its recognition sequence and on NF-kappa B-dependent gene expression was examined in T lymphoid Jurkat cell lines (19D and 9J) stably transformed with a Tax expression vector.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	lymphoid	lymphoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	19D	19D	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	9J	9J	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	stably	stably	ADV	RB	_	_	_	_	_
43	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
48	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1561
# text = Tax expressing T cell lines contained a constitutive level of NF-kappa B binding activity, detectable by mobility shift assay and uv cross-linking using a palindromic NF-kappa B probe homologous to the interferon beta PRDII site.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
3	T	t	NUM	CD	NumType=Card	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	uv	uv	NOUN	NN	Number=Sing	_	_	_	_
25	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
27	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	probe	probe	ADV	RB	_	_	_	_	_
35	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
39	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
40	PRDII	Prdii	PROPN	NNP	Number=Sing	_	_	_	_
41	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1562
# text = In Jurkat and NC2.10 induction with phorbol esters resulted in the appearance of new DNA binding proteins of 85, 75, and 54 kDa, whereas in Tax expressing cells the 85-kDa protein and a 92-kDa DNA binding protein were constitutively induced.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NC2.10	NC2.10	NUM	CD	NumType=Card	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	85	85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	54	54	NUM	CD	NumType=Card	_	_	_	_
25	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	whereas	wherea	SCONJ	IN	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
30	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	85	85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
42	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
43	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	constitutively	constitutively	ADV	RB	_	_	_	_	_
47	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1563
# text = Expression of Tax protein in 19D and 9J resulted in transcription of the endogenous NF-kappa B-dependent granulocyte-macrophage colony stimulating factor gene and increased basal level expression of transfected NF-kappa B-regulated promoters.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	19D	19D	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	9J	9J	PROPN	NNP	Number=Sing	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
25	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
31	level	level	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1564
# text = Nonetheless transcription of both the endogenous and the transfected gene was inducible by PMA treatment.
1	Nonetheless	nonetheless	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transfected	transfect	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1565
# text = Tax expression in Jurkat
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1566
# text = T cells may alter the stoichiometry of NF-kappa B DNA binding proteins and thus change the expression of NF-kappa B-regulated promoters.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	stoichiometry	stoichiometry	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	thus	thus	ADV	RB	_	_	_	_	_
17	change	change	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1567
# text = Document 003002568 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002568	003002568	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1568
# text = Identification and characterization of a leukocyte-specific component of the nuclear body.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	body	body	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1569
# text = The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	body	body	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	NB	NB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	organelle	organelle	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
19	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1570
# text = The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NB	Nb	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	target	target	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
17	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	biliary	biliary	ADJ	JJ	Degree=Pos	_	_	_	_
20	cirrhosis	cirrhosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1571
# text = In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	biliary	biliary	ADJ	JJ	Degree=Pos	_	_	_	_
12	cirrhosis	cirrhosis	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
19	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
22	component	component	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	NB	NB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	140	140	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1572
# text = The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	amino	amino	DET	DT	_	_	_	_	_
4	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	Sp100	Sp100	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
22	NB	NB	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1573
# text = The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
3	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	bromodomain	bromodomain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1574
# text = High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	spleen	spleen	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	ADV	RB	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1575
# text = The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	140	140	NUM	CD	NumType=Card	_	_	_	_
6	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
9	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	HL60	HL60	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	_
15	markedly	markedly	ADV	RB	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	chemically	chemically	ADV	RB	_	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1576
# text = Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells.
1	Immunohistochemical	Immunohistochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	techniques	technique	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	140	140	NUM	CD	NumType=Card	_	_	_	_
10	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NB	NB	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	differentiated	differentiated	PROPN	NNP	Number=Sing	_	_	_	_
16	HL60	HL60	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1577
# text = The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	location	location	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Sp140	Sp140	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NB	NB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	host	host	NOUN	NN	Number=Sing	_	_	_	_
19	defense	defense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
32	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1578
# text = Document 003002570 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002570	003002570	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1579
# text = Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	pokeweed	pokeweed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1580
# text = The present studies have examined the effects of pokeweed mitogen (PWM) on the induction of early growth response-1 gene (EGR-1) in normal human B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	pokeweed	pokeweed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1581
# text = PWM regulates EGR-1 gene expression by both transcriptional and post-transcriptional mechanisms.
1	PWM	PWM	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	post-transcriptional	post-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1582
# text = Transient transfection assays with EGR-1 promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene demonstrated that PWM induced EGR-1 transcription is conferred by the CArG motif (C C[AT]6GG) in the EGR-1 promoter.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
14	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	gene	gene	PRON	NN	Number=Sing	_	_	_	_
19	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
22	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	CArG	CArG	PROPN	NNP	Number=Sing	_	_	_	_
32	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	C	C	PROPN	NNP	Number=Sing	_	_	_	_
35	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	6GG	6gg	INTJ	UH	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1583
# text = The results further demonstrated the activation of S6 kinase (pp90rsk), evidenced by phosphorylation of S6 and serum response factor (SRF) peptides, in PWM treated B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	S6	S6	NUM	CD	NumType=Card	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	S6	s6	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
30	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1584
# text = Taken together, these findings suggest that PWM is able to initiate an intracytoplasmic signalling cascade and EGR-1 induction in normal human B cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
16	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1585
# text = Document 003002578 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002578	003002578	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1586
# text = Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs.
1	Autoregulation	Autoregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
9	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	p65	p65	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
17	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
18	ankyrin	ankyrin	ADP	IN	_	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1587
# text = RelA (p65) functions as the critical transactivating component of the heterodimeric p50-p65 NF-kappa B complex and contains a high-affinity binding site for its cytoplasmic inhibitor, I kappa B alpha.
1	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	transactivating	transactivating	NOUN	NN	Number=Sing	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
33	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1588
# text = After cellular activation, I kappa B alpha is rapidly degraded in concert with the induced nuclear translocation of NF-kappa B.
1	After	after	ADP	IN	_	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1589
# text = The present study demonstrates that tumor necrosis factor alpha-induced degradation of I kappa B alpha in human T cells is preceded by its rapid phosphorylation in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1590
# text = However, these effects on I kappa B alpha result in nuclear mobilization of only a fraction of the entire cytoplasmic pool of RelA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	GW	_	_	_	_	_
8	B	b	X	GW	_	_	_	_	_
9	alpha	alpha	X	GW	_	_	_	_	_
10	result	result	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
22	pool	pool	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1591
# text = Subsequent studies have revealed that (i) cytoplasmic RelA is stably associated not only with I kappa B alpha but also with other ankyrin motif-rich proteins including the products of the NF-kappa B2 (p100) and NF-kappa B1 (p105) genes; (ii) in contrast to RelA-I kappa B alpha, RelA-p100 cytoplasmic complexes are not dissociated following tumor necrosis factor alpha activation; (iii) p100 functions as a potent inhibitor of RelA-mediated transcription in vivo; (iv) the interaction of RelA and p100 involves the conserved Rel homology domain of both proteins but not the nuclear localization signal of RelA, which is required for I kappa B alpha binding; (v) p100 inhibition of RelA function requires the C-terminal ankyrin motif domain, which mediates cytoplasmic retention of RelA; and (vi) as observed with I kappa B alpha, nuclear RelA stimulates p100 mRNA and protein expression.
1	Subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
10	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	stably	stably	ADV	RB	_	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	with	with	SCONJ	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	products	product	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
46	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	;	;	PUNCT	,	_	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
57	to	to	ADP	IN	_	_	_	_	_
58	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
60	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
61	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
62	B	b	PROPN	NNP	Number=Sing	_	_	_	_
63	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
67	p100	p100	NUM	CD	NumType=Card	_	_	_	_
68	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
69	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
70	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
71	not	not	PART	RB	_	_	_	_	_
72	dissociated	dissociate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
73	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
74	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
75	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
76	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
77	alpha	alpha	ADP	IN	_	_	_	_	_
78	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
79	;	;	PUNCT	,	_	_	_	_	_
80	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
81	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
82	)	)	PUNCT	-RRB-	_	_	_	_	_
83	p100	p100	NUM	CD	NumType=Card	_	_	_	_
84	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
85	as	as	ADP	IN	_	_	_	_	_
86	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
87	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
88	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
89	of	of	ADP	IN	_	_	_	_	_
90	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
91	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
92	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
93	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
94	in	in	ADP	IN	_	_	_	_	_
95	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
96	;	;	PUNCT	,	_	_	_	_	_
97	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
98	iv	iv	X	ADD	_	_	_	_	SpaceAfter=No
99	)	)	PUNCT	-RRB-	_	_	_	_	_
100	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
101	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
102	of	of	ADP	IN	_	_	_	_	_
103	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
104	and	and	CCONJ	CC	_	_	_	_	_
105	p100	p100	NUM	CD	NumType=Card	_	_	_	_
106	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
107	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
108	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
109	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
110	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
111	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
112	of	of	ADP	IN	_	_	_	_	_
113	both	both	DET	DT	_	_	_	_	_
114	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
115	but	but	CCONJ	CC	_	_	_	_	_
116	not	not	PART	RB	_	_	_	_	_
117	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
118	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
119	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
120	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
121	of	of	ADP	IN	_	_	_	_	_
122	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
123	,	,	PUNCT	,	_	_	_	_	_
124	which	which	PRON	WDT	PronType=Rel	_	_	_	_
125	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
126	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
127	for	for	SCONJ	IN	_	_	_	_	_
128	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
129	kappa	kappa	X	GW	_	_	_	_	_
130	B	b	X	GW	_	_	_	_	_
131	alpha	alpha	X	GW	_	_	_	_	_
132	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
133	;	;	PUNCT	,	_	_	_	_	_
134	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
135	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
136	)	)	PUNCT	-RRB-	_	_	_	_	_
137	p100	p100	NUM	CD	NumType=Card	_	_	_	_
138	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
139	of	of	ADP	IN	_	_	_	_	_
140	RelA	Rela	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
141	function	function	NOUN	NN	Number=Sing	_	_	_	_
142	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
143	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
144	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
145	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
146	ankyrin	ankyrin	ADP	IN	_	_	_	_	_
147	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
148	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
149	,	,	PUNCT	,	_	_	_	_	_
150	which	which	PRON	WDT	PronType=Rel	_	_	_	_
151	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
152	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
153	retention	retention	NOUN	NN	Number=Sing	_	_	_	_
154	of	of	ADP	IN	_	_	_	_	_
155	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
156	;	;	PUNCT	,	_	_	_	_	_
157	and	and	CCONJ	CC	_	_	_	_	_
158	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
159	vi	vi	X	LS	_	_	_	_	SpaceAfter=No
160	)	)	PUNCT	-RRB-	_	_	_	_	_
161	as	as	ADP	IN	_	_	_	_	_
162	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
163	with	with	ADP	IN	_	_	_	_	_
164	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
165	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
166	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
167	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
168	,	,	PUNCT	,	_	_	_	_	_
169	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
170	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
171	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
172	p100	p100	NUM	CD	NumType=Card	_	_	_	_
173	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
174	and	and	CCONJ	CC	_	_	_	_	_
175	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
176	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
177	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1592
# text = These findings thus reveal the presence of a second inducible autoregulated inhibitory pathway that helps ensure the rapid but transient action of nuclear NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	autoregulated	autoregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	helps	help	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	ensure	ensure	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
21	action	action	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1593
# text = Document 003002582 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002582	003002582	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1594
# text = Functional interaction between the two zinc finger domains of the v-erb A oncoprotein.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
7	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
8	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	erb	erb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
13	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1595
# text = The v-erb
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1596
# text = A oncogene of avian erythroblastosis virus is a mutated and virally transduced copy of a host cell gene encoding a thyroid hormone receptor.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	avian	avian	ADJ	JJ	Degree=Pos	_	_	_	_
5	erythroblastosis	erythroblastosis	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	mutated	mutate	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	virally	virally	ADV	RB	_	_	_	_	_
12	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	host	host	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
22	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1597
# text = The protein expressed by the v-erb A oncogene binds to DNA and acts as a dominant negative inhibitor of both the thyroid hormone receptor and the closely related retinoic acid receptor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	erb	erb	ADJ	JJ	Degree=Pos	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
10	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
18	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
24	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	closely	closely	ADV	RB	_	_	_	_	_
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
31	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1598
# text = The v-erb
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1599
# text = A protein has sustained two amino acid alterations within its DNA-binding domain relative to that of c-erb A, one of which, at serine 61, is known to be important for v-erb A function in the neoplastic cell.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	amino	amino	DET	DT	_	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
8	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
15	relative	relative	ADV	RB	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	erb	erb	NOUN	NN	Number=Sing	_	_	_	_
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	one	one	NUM	CD	NumType=Card	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Int	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
29	61	61	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	erb	erb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	function	function	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1600
# text = We report here that the second alteration, at threonine 78, also plays an important, although more indirect, role: alteration of the sequence at threonine 78 such that it resembles that of c-erb
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
11	78	78	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
20	indirect	indirect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
30	78	78	NUM	CD	NumType=Card	_	_	_	_
31	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
34	resembles	resemble	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1601
# text = A can act as an intragenic suppressor and can partially restore function to a v-erb
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	intragenic	intragenic	ADJ	JJ	Degree=Pos	_	_	_	_
7	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	partially	partially	ADV	RB	_	_	_	_	_
11	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1602
# text = A protein rendered defective due to a mutation at position 61.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
5	due	due	ADP	IN	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	position	position	NOUN	NN	Number=Sing	_	_	_	_
11	61	61	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1603
# text = Threonine 78 lies within the D-box of the v-erb A protein, a region thought to mediate receptor-receptor dimerizations, and is not in physical proximity to the serine at position 61.
1	Threonine	Threonine	NUM	CD	NumType=Card	_	_	_	_
2	78	78	NUM	CD	NumType=Card	_	_	_	_
3	lies	lie	NOUN	NNS	Number=Plur	_	_	_	_
4	within	within	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	D-	d-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	erb	erb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	thought	think	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	dimerizations	dimerization	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
30	proximity	proximity	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	position	position	NOUN	NN	Number=Sing	_	_	_	_
36	61	61	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1604
# text = It therefore appears that an indirect interaction occurs between these two sites and that this interaction is crucial for v-erb
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1605
# text = A function.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1606
# text = Document 003002583 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002583	003002583	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1607
# text = Abnormal T lymphocyte development induced by targeted overexpression of IkappaB alpha.
1	Abnormal	abnormal	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1608
# text = A role in thymic maturation for factors of the NF-kappaB family has long been suspected, but not yet proven.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
5	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	long	long	ADV	RB	Degree=Pos	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	suspected	suspect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	yet	yet	ADV	RB	_	_	_	_	_
22	proven	prove	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1609
# text = Transgenic mice with a lymphocyte-specific defect in NF-kappaB activation were produced by targeted expression of human IkappaB alpha.
1	Transgenic	Transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1610
# text = The thymic cellularity of these mice was significantly decreased.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cellularity	cellularity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1611
# text = The proportion of mature, TCRhigh thymocytes of the alphabeta lineage was reduced, and the remaining TCRhigh population contained an unusually high proportion of double-positive cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mature	mature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	TC	tc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	Rhigh	Rhigh	PROPN	NNP	Number=Sing	_	_	_	_
8	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	alphabeta	alphabeta	NOUN	NN	Number=Sing	_	_	_	_
12	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	remaining	remain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	TC	tc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	Rhigh	Rhigh	PROPN	NNP	Number=Sing	_	_	_	_
21	population	population	NOUN	NN	Number=Sing	_	_	_	_
22	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	unusually	unusually	ADV	RB	_	_	_	_	_
25	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
26	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1612
# text = This defect in maturation resulted in a transgene dose-dependent reduction in peripheral T lymphocytes, with the CD8 lineage being more severely affected.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	transgene	transgene	NOUN	NN	Number=Sing	_	_	_	_
9	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CD8	Cd8	NOUN	NN	Number=Sing	_	_	_	_
21	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
22	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
23	more	more	ADV	RBR	_	_	_	_	_
24	severely	severely	ADV	RB	_	_	_	_	_
25	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1613
# text = These data provide direct evidence for the involvement of NF-kappaB/Rel family proteins in late stages of T lymphocyte development, coincident with positive and negative selection.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
19	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
23	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	coincident	coincident	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
30	selection	selection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1614
# text = Document 003002587 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002587	003002587	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1615
# text = Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	rel/	relith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	transdominant	transdominant	ADJ	JJ	Degree=Pos	_	_	_	_
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1616
# text = The KBF1 factor, which binds to the enhancer
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1617
# text = A located in the promoter of the mouse MHC class I gene H-2Kb, is indistinguishable from the p50 DNA binding subunit of the transcription factor NF-kappa B, which regulates a series of genes involved in immune and inflammatory responses.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	Kb	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
25	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	series	series	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
41	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
46	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1618
# text = The KBF1/p50 factor binds as a homodimer but can also form heterodimers with the products of other members of the same family, like the c-rel and v-rel (proto)oncogenes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	KBF1/p50	KBF1/p50	PROPN	NNP	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
12	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	products	product	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	like	like	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	v-rel	v-rel	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1619
# text = The dimerization domain of KBF1/p50 is contained between amino acids 201 and 367.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	KBF	KBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	amino	amino	DET	DT	_	_	_	_	_
13	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
14	201	201	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	367	367	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1620
# text = A mutant of KBF1/p50 (delta SP), unable to bind to DNA but able to form homo- or heterodimers, has been constructed.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	KBF1/	Kbf1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	p50	p50	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
8	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
20	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1621
# text = This protein reduces or abolishes in vitro the DNA binding activity of wild-type proteins of the same family (KBF1/p50, c- and v-rel).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	reduces	reduce	NOUN	NNS	Number=Plur	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	abolishes	abolish	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	KBF	KBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	1/	1/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	v-rel	v-rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1622
# text = This mutant also functions in vivo as a trans-acting dominant negative regulator: the transcriptional inducibility of the HIV long terminal repeat (which contains two potential NF-kappa B binding sites) by phorbol ester (PMA) is inhibited when it is co-transfected into CD4+ T cells with the delta SP mutant.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	trans	tran	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
13	negative	negative	NOUN	NN	Number=Sing	_	_	_	_
14	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
39	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	when	when	ADV	WRB	PronType=Int	_	_	_	_
46	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
47	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	into	into	ADP	IN	_	_	_	_	_
50	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	+	+	SYM	SYM	_	_	_	_	_
52	T	t	NUM	CD	NumType=Card	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	with	with	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
57	SP	sp	PROPN	NNP	Number=Sing	_	_	_	_
58	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1623
# text = Similarly the basal as well as TNF or IL1-induced activity of the MHC class I H-2Kb promoter can be inhibited by this mutant in two different cell lines.
1	Similarly	similarly	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IL1	IL1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
16	class	class	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	H	h	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	Kb	kb	NOUN	NN	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1624
# text = These results constitute the first formal demonstration that these genes are regulated by members of the rel/NF-kappa B family.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	constitute	constitute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADV	RBS	_	_	_	_	_
6	formal	formal	ADJ	JJ	Degree=Pos	_	_	_	_
7	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	members	member	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	rel/	rel/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1625
# text = Document 003002588 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002588	003002588	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1626
# text = Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
3	class	class	NOUN	NN	Number=Sing	_	_	_	_
4	II	ii	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
11	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
23	MHC	mhc	PROPN	NNP	Number=Sing	_	_	_	_
24	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
26	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1627
# text = Type II major histocompatibility complex combined immune deficiency (type II MHC CID or bare lymphocyte syndrome) is a congenital immunodeficiency disease characterized by absent MHC class II expression.
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	_
3	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
4	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
13	CID	CID	PROPN	NNP	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	bare	bear	ADJ	JJ	Degree=Pos	_	_	_	_
16	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
17	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	congenital	congenital	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
24	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
28	class	class	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1628
# text = Four distinct complementation groups have been identified.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
4	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1629
# text = Recently, the defective gene in group II type II MHC CID has been isolated and termed CIITA.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	group	group	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	CID	CID	PROPN	NNP	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	CIITA	CIITa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1630
# text = Here, we demonstrate that CIITA is an MHC class II gene-specific transcription activator.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	gene-	gene-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1631
# text = The transcription activation function is provided by the N-terminal acidic domain (amino acids 26-137), which is experimentally exchangeable with a heterologous viral transcription-activating domain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	amino	amino	DET	DT	_	_	_	_	_
15	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
16	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	137	137	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	experimentally	experimentally	ADV	RB	_	_	_	_	_
24	exchangeable	exchangeable	ADJ	JJ	Degree=Pos	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
28	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1632
# text = The specificity of CIITA for three major MHC class II genes, DR, DQ and DP, is mediated by its remaining C-terminal residues (amino acids 317-1130).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	three	three	NUM	CD	NumType=Card	_	_	_	_
7	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	DR	dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	DP	DP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	remaining	remain	VERB	VBG	VerbForm=Ger	_	_	_	_
24	C-	C-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
26	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	amino	amino	DET	DT	_	_	_	_	_
29	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
30	317	317	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	1130	1130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1633
# text = The transactivation of multiple cis elements, especially S and X2, of the DR alpha proximal promoter in group II CID cells is CIITA dependent.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	especially	especially	ADV	RB	_	_	_	_	_
9	S	S	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	X2	X2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	group	group	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	CID	Cid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	CIITA	CIITA	X	GW	_	_	_	_	_
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1634
# text = Since CIITA overexpression in normal cells did not increase class II expression, we propose that initiation of CIITA expression serves as the on-off switch, while availability of downstream interactor(s) limits transcription.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	off	off	ADJ	JJ	Degree=Pos	_	_	_	_
27	switch	switch	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
33	interactor	interactor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	s	s	X	AFX	_	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	limits	limit	NOUN	NNS	Number=Plur	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1635
# text = Document 003002594 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002594	003002594	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1636
# text = Induction of Sp1 phosphorylation and NF-kappa B-independent HIV promoter domain activity in T lymphocytes stimulated by okadaic acid.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
22	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1637
# text = In contrast to the purely enhancer-dependent effect of cytokines such as TNF on the activity of the HIV regulatory region (LTR), we observed that okadaic acid (OKA) activates
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	purely	purely	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
28	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
31	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	OKA	OKA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 1638
# text = HIV transcription through both the enhancer, responding to the factor NF-kappa B, and the promoter domain of the LTR.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1639
# text = The inducibility of HIV LTR-driven luciferase expression constructs in lymphoblastoid cells stimulated by OKA depended on both functional Sp1 binding elements and the ability of the TATA box to bind the protein TBP.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
5	LTR-	LTR-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	_
16	depended	depend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	TATA	TATA	PROPN	NNP	Number=Sing	_	_	_	_
29	box	box	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1640
# text = In both transformed and normal lymphocytes, OKA stimulation induced intense phosphorylation of the constitutively expressed Sp1 protein in the nucleus, a property of OKA not shared by TNF, phorbol ester, or PHA and interleukin 2.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	CCONJ	CC	_	_	_	_	_
3	transformed	transformed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	intense	intense	ADJ	JJ	Degree=Pos	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	constitutively	constitutively	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	property	property	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
33	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	PHA	PHa	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1641
# text = Responsiveness of LTR constructs deleted of kappa B elements to HIV Tat expression was increased upon OKA but not TNF stimulation.
1	Responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	_
4	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
5	deleted	delet	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
12	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	upon	upon	ADP	IN	_	_	_	_	_
17	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	TNF	Tnf	ADP	IN	_	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1642
# text = Our results suggest that SP1 phosphorylation induced by OKA, a selective inhibitor of the serine-threonine phosphatase PP2A, facilitates the formation of a transcription complex involving general transcription factors, HIV Tat, and Sp1 proteins.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
20	PP2	Pp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	facilitates	facilitate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
30	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
31	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
36	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1643
# text = The formation of this complex would increase, independently of an in synergy with NF-kappa B, the low basal activity of the HIV LTR observed in normal T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
7	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	independently	independently	ADV	RB	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
27	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
28	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1644
# text = Document 003002595 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002595	003002595	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1645
# text = Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	association	association	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1646
# text = Using the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	coiled	coil	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	coil	coil	NOUN	NN	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	b	b	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	bait	bait	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
19	screen	screen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	association	association	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_

# sent_id = 1647
# text = Nmi, a protein of unknown function previously reported as an N-Myc interactor.
1	Nmi	Nmi	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	previously	previously	ADV	RB	_	_	_	_	_
9	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
15	interactor	interactor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1648
# text = We further show that Nmi interacts with all STATs except Stat2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	STATs	STAT	NOUN	NNS	Number=Plur	_	_	_	_
10	except	except	ADP	IN	_	_	_	_	_
11	Stat2	stat2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1649
# text = We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
17	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
18	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1650
# text = Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
4	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	instead	instead	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
14	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	association	association	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	p300	p300	NUM	CD	NumType=Card	_	_	_	_
21	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	together	together	ADV	RB	_	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	p300	p300	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1651
# text = Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	potentiate	potentiate	VERB	VB	VerbForm=Inf	_	_	_	_
12	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
24	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	at	at	ADV	RB	_	_	_	_	_
29	least	least	ADV	RBS	Degree=Sup	_	_	_	_
30	some	some	DET	DT	_	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	group	group	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1652
# text = Document 003002600 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002600	003002600	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1653
# text = Vitamin
1	Vitamin	Vitamin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1654
# text = D receptor 3'-untranslated region polymorphisms:
1	D	would	NOUN	NN	Number=Sing	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1655
# text = lack of effect on mRNA stability.
1	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1656
# text = Allelic variation at the 3'-end of the vitamin D receptor (VDR) gene has been associated with a 3-5-fold increased risk of developing prostate cancer and with differences in bone mineralization.
1	Allelic	Allelic	ADJ	JJ	Degree=Pos	_	_	_	_
2	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	end	end	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
12	D	d	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
28	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
32	prostate	prostate	NOUN	NN	Number=Sing	_	_	_	_
33	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
39	mineralization	mineralization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1657
# text = This genetic diversity does not alter the VDR protein structurally, but instead may be a marker(s) of other, nearby polymorphisms that influence message stability or translation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
3	diversity	diversity	NOUN	NN	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	structurally	structurally	ADV	RB	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	instead	instead	ADV	RB	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	marker	marker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	s	s	X	AFX	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	nearby	nearby	ADJ	JJ	Degree=Pos	_	_	_	_
25	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	influence	influence	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	message	message	NOUN	NN	Number=Sing	_	_	_	_
29	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	translation	translation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1658
# text = The work reported here was instigated to identify additional VDR 3'-UTR polymorphisms that may have functional significance and to then test whether these genetic variants alter message stability.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	instigated	instigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
9	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
10	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	UTR	UTR	ADJ	JJR	Degree=Cmp	_	_	_	_
15	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	then	then	ADV	RB	PronType=Dem	_	_	_	_
24	test	test	NOUN	NN	Number=Sing	_	_	_	_
25	whether	whether	SCONJ	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
28	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
29	alter	alter	NOUN	NN	Number=Sing	_	_	_	_
30	message	message	NOUN	NN	Number=Sing	_	_	_	_
31	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1659
# text = Initially, four novel, frequently occurring sequence variants were identified that associated with two common haplotypes that were described previously.
1	Initially	initially	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	four	four	NUM	CD	NumType=Card	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	frequently	frequently	ADV	RB	_	_	_	_	_
7	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
17	haplotypes	haplotype	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1660
# text = These common sequence variants were not found within three message-destabilizing elements that we mapped within the 3'-UTR of the vitamin D receptor mRNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	message	message	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	destabilizing	destabilize	VERB	VBG	VerbForm=Ger	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	UTR	Utr	ADP	IN	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
26	D	would	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1661
# text = Furthermore, the two VDR 3'-UTR haplotypes conferred an identical half-life on a heterologous beta-globin reporter gene, in an in vitro assay.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	UTR	UTR	PROPN	NNP	Number=Sing	_	_	_	_
10	haplotypes	haplotype	NOUN	NNS	Number=Plur	_	_	_	_
11	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
14	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	life	life	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
30	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1662
# text = We therefore conclude that common polymorphisms within the VDR 3'-UTR do not influence message stability.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
6	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	VDR	Vdr	PROPN	NNP	Number=Sing	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	UTR	Utr	PROPN	NNP	Number=Sing	_	_	_	_
14	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
17	message	message	NOUN	NN	Number=Sing	_	_	_	_
18	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1663
# text = Document 0030031 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030031	0030031	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1664
# text = Circadian rhythm of glucocorticoid receptors in human peripheral leukocytes and their reactivity to glucocorticoids.
1	Circadian	Circadian	ADJ	JJ	Degree=Pos	_	_	_	_
2	rhythm	rhythm	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1665
# text = 1) There exists a CR of GR in human leukocytes, PMN, and monocytes with the peak values from 0400 to 0800 hr and the trough values between 2300 and 0000 hr.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	There	there	PRON	EX	_	_	_	_	_
4	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	CR	Cr	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PMN	Pmn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
20	values	value	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	0400	0400	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	0800	0800	NUM	CD	NumType=Card	_	_	_	_
25	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	trough	trough	ADJ	JJ	Degree=Pos	_	_	_	_
29	values	value	NOUN	NNS	Number=Plur	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	2300	2300	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	0000	0000	NUM	CD	NumType=Card	_	_	_	_
34	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1666
# text = The difference between them was significant statistically.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	statistically	statistically	ADV	RB	_	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1667
# text = 2) The FI of the chemotactic migration rate of PMN by cortisol also showed diurnal changes which were synchronous with that of GR.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	FI	fi	PROPN	NNP	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
8	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
9	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PMN	PMN	PROPN	NNP	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	cortisol	cortisol	PROPN	NNP	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	diurnal	diurnal	ADJ	JJ	Degree=Pos	_	_	_	_
17	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	synchronous	synchronous	ADJ	JJ	Degree=Pos	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1668
# text = This indicates that the CR of GR may be of functional significance.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CR	Cr	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	significance	significance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1669
# text = 3) In Cushing's syndrome, the CR of GR was normal in spite of the fact that the CR of plasma cortisol was disturbed.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	's	's	PART	POS	_	_	_	_	_
6	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CR	Cr	PROPN	NNP	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CR	Cr	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
24	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	disturbed	distur	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1670
# text = This indicates the independency of the CR of GR from that of cortisol.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	independency	independency	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CR	CR	PROPN	NNP	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1671
# text = 4) In apoplexy caused by brain ischemia, the CR of GR was abolished in patients with basal lesions but preserved when the lesions were located in the cerebral cortex.
1	4	4	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	apoplexy	apoplexy	NOUN	NN	Number=Sing	_	_	_	_
5	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	brain	brain	NOUN	NN	Number=Sing	_	_	_	_
8	ischemia	ischemion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CR	CR	PROPN	NNP	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
20	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	preserved	preserve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	when	when	ADV	WRB	PronType=Int	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cerebral	cerebral	ADJ	JJ	Degree=Pos	_	_	_	_
31	cortex	cortex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1672
# text = These results strongly suggest that the main "circadian pacemaker" of GR is located in the basal brain, most probably in the suprachiasmatic nuclei as has been suggested for rodents.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
8	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
9	circadian	circadian	ADJ	JJ	Degree=Pos	_	_	_	_
10	pacemaker	pacemaker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	"	"	PUNCT	''	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
19	brain	brain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	probably	probably	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	suprachiasmatic	suprachiasmatic	ADJ	JJ	Degree=Pos	_	_	_	_
26	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
27	as	as	SCONJ	IN	_	_	_	_	_
28	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	rodents	rodent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1673
# text = Document 0030032 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030032	0030032	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1674
# text = Progesterone suppression of pregnancy lymphocytes is not mediated by glucocorticoid effect.
1	Progesterone	Progesterone	NOUN	NN	Number=Sing	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	pregnancy	pregnancy	ADJ	JJ	Degree=Pos	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1675
# text = This study investigated whether the suppressive effect of progesterone on pregnancy lymphocytes is mediated by specific progesterone receptors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	pregnancy	pregnancy	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1676
# text = The effects of a competitive progesterone antagonist (RU486) and a specific glucocorticoid receptor blocker (RU43044) were tested on the release of a blocking factor by progesterone-treated pregnancy lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
7	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RU486	RU486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	blocker	blocker	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	RU43044	RU43044	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1677
# text = RU 486 tested at an equal concentration as progesterone significantly inhibited the production of the blocking factor, while RU 43044 was without effect.
1	RU	Ru	PROPN	NNP	Number=Sing	_	_	_	_
2	486	486	NUM	CD	NumType=Card	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	_
7	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	SCONJ	IN	_	_	_	_	_
9	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	blocking	blocking	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	RU	RU	PROPN	NNP	Number=Sing	_	_	_	_
21	43044	43044	NUM	CD	NumType=Card	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	without	without	ADP	IN	_	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1678
# text = These data suggest that in pregnancy, lymphocyte progesterone acts on specific progesterone receptors and glucocorticoid binding sites are not involved.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
9	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
10	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	glucocorticoid	glucocorticoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1679
# text = Document 0030033 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030033	0030033	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1680
# text = Infection with Theileria annulata induces expression of matrix metalloproteinase 9 and transcription factor AP-1 in bovine leucocytes.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	Theileria	Theileria	PROPN	NNP	Number=Sing	_	_	_	_
4	annulata	annulata	PART	TO	Abbr=Yes	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	matrix	matrix	NUM	CD	NumType=Card	_	_	_	_
9	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
10	9	9	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	bovine	bovine	ADJ	JJ	Degree=Pos	_	_	_	_
19	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1681
# text = Theileria annulata infects bovine leucocytes and results in their reversible transformation such that they become immortalised and metastatic.
1	Theileria	Theileria	PROPN	NNP	Number=Sing	_	_	_	_
2	annulata	annulata	PART	TO	Abbr=Yes	_	_	_	_
3	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
5	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
11	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	become	become	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	immortalised	immortalised	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1682
# text = The present study describes parasite-induced changes in host cell gene expression which have a direct bearing on this transformation process.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	describes	describe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	host	host	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
18	bearing	bearing	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
22	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1683
# text = T. annulata-infected leucocytes produce a number of novel metalloproteinase activities.
1	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_
2	annulata	annulata	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
11	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
12	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1684
# text = One of these, previously called B1, is a 97-kDa protein which is secreted in large amounts and has been purified from protein-free, conditioned medium.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	B1	b1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	97	97	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
20	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	free	free	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	conditioned	condition	ADJ	JJ	Degree=Pos	_	_	_	_
30	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1685
# text = An antiserum to this enzyme was used to isolate a cDNA clone.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
12	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1686
# text = The predicted protein sequence of B1 is 81% identical to human matrix metalloproteinase 9 (MMP9), demonstrating that it is the bovine homologue of this enzyme.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	81	81	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	%	%	SYM	NN	Number=Sing	_	_	_	_
10	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
14	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
15	9	9	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	MMP9	Mmp9	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
26	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1687
# text = RNAase protection assays demonstrated that the MMP9 activity, unique to infected cells, is due to increased MMP9 mRNA levels.
1	RNAase	RNAase	NOUN	NN	Number=Sing	_	_	_	_
2	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	MMP9	MMP9	PROPN	NNP	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	MMP9	MMP9	PROPN	NNP	Number=Sing	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1688
# text = We also assayed the levels of transcription factor AP-1 and demonstrated that it was constitutively present in increased amounts in Theileria-infected cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	assayed	assay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	constitutively	constitutively	ADV	RB	_	_	_	_	_
18	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Theileria	Theileria	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1689
# text = In addition we assayed the level of mRNA encoding c-Fos, a common component of AP-1 and observed that it was indeed up-regulated in infected cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	assayed	assay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	indeed	indeed	ADV	RB	_	_	_	_	_
26	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1690
# text = Since AP-1 is implicated in the control of the cell cycle, and MMP9 can confer metastatic properties, these results are of considerable significance with respect to the transformed phenotype induced by Theileria infection.
1	Since	since	ADP	IN	_	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	MMP9	MMP9	PROPN	NNP	Number=Sing	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
19	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
20	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	results	result	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
27	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	Theileria	Theileria	PROPN	NNP	Number=Sing	_	_	_	_
37	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1691
# text = Document 0030036 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030036	0030036	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1692
# text = Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.
1	Tyloxapol	Tyloxapol	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	scavenges	scavenge	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	HOCI	HOCI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	viscosity	viscosity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cystic	cystic	ADJ	JJ	Degree=Pos	_	_	_	_
19	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	_
20	sputum	sputum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1693
# text = Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy.
1	Cystic	Cystic	ADJ	JJ	Degree=Pos	_	_	_	_
2	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CF	CF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
7	develop	develop	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	thick	thick	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	tenacious	tenacious	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	protease	protease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
30	purulent	purulent	ADJ	JJ	Degree=Pos	_	_	_	_
31	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
32	secretions	secretion	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	difficult	difficult	ADJ	JJ	Degree=Pos	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	clear	clear	VERB	VB	VerbForm=Inf	_	_	_	_
38	even	even	ADV	RB	_	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	physiotherapy	physiotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1694
# text = In the search for a potential treatment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	search	search	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	tyloxapol	tyloxapol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	alkylaryl	alkylaryl	ADJ	JJ	Degree=Pos	_	_	_	_
16	polyether	polyether	NOUN	NN	Number=Sing	_	_	_	_
17	alcohol	alcohol	NOUN	NN	Number=Sing	_	_	_	_
18	polymer	polymer	NOUN	NN	Number=Sing	_	_	_	_
19	detergent	detergent	NOUN	NN	Number=Sing	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	mucolytic	mucolytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
28	chronic	chronic	NOUN	NN	Number=Sing	_	_	_	_
29	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1695
# text = Tyloxapol inhibits activation of the transcription factor nuclear factor-kappa B (NK-kappa B), reduces resting secretion of the cytokine interleukin-8 (IL-8) in cultured human monocytes, and inhibits lipopolysaccharide (LPS)-stimulated release of tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and the eiconsanoids thromboxane A2 and leukotriene B4 (LTB4).
1	Tyloxapol	Tyloxapol	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NK	Nk	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	8	8	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	8	8	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	inhibits	inhibits	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
41	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	release	release	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
50	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
51	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	1	1	NUM	CD	NumType=Card	_	_	_	_
63	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
74	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
75	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
76	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
79	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
80	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
81	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
82	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
83	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
84	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	and	and	CCONJ	CC	_	_	_	_	_
87	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
88	eiconsanoids	eiconsanoid	NOUN	NNS	Number=Plur	_	_	_	_
89	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
90	A2	a2	NOUN	NN	Number=Sing	_	_	_	_
91	and	and	CCONJ	CC	_	_	_	_	_
92	leukotriene	leukotriene	NOUN	NN	Number=Sing	_	_	_	_
93	B4	B4	PROPN	NNP	Number=Sing	_	_	_	_
94	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
95	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
96	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
97	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1696
# text = We have previously shown that tyloxapol is a potent antioxidant for hydroxyl radicals ( OH).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	tyloxapol	tyloxapol	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
10	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	hydroxyl	hydroxyl	NOUN	NN	Number=Sing	_	_	_	_
13	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	_
15	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1697
# text = Tyloxapol (0.05 to 0.1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and protects from HOCl-mediated lung injury in rats.
1	Tyloxapol	Tyloxapol	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	0.05	0.05	NUM	CD	NumType=Card	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	0.1	0.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	%	%	SYM	NN	Number=Sing	_	_	_	_
7	wt	wt	ADJ	JJS	Degree=Sup	_	_	_	SpaceAfter=No
8	/vol	/vol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	effectively	effectively	ADV	RB	_	_	_	_	_
11	scavenges	scavenge	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
14	hypochlorous	hypochlorous	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HOCl	HOCl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	7.5	7.5	NUM	CD	NumType=Card	_	_	_	_
22	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	protects	protect	NOUN	NNS	Number=Plur	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
34	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	rats	rat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1698
# text = Tyloxapol also reduces the viscosity of CF sputum (from 463 +/- 133 to 128 +/- 52 centipoise).
1	Tyloxapol	Tyloxapol	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	viscosity	viscosity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CF	CF	PROPN	NNP	Number=Sing	_	_	_	_
8	sputum	sputum	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	from	from	ADP	IN	_	_	_	_	_
11	463	463	NUM	CD	NumType=Card	_	_	_	_
12	+/-	+/-	SYM	SYM	_	_	_	_	_
13	133	133	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	128	128	NUM	CD	NumType=Card	_	_	_	_
16	+/-	+/-	SYM	SYM	_	_	_	_	_
17	52	52	NUM	CD	NumType=Card	_	_	_	_
18	centipoise	centipoise	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1699
# text = We conclude that tyloxapol is potentially useful as a new antiinflammatory therapy for CF lung disease, and could possibly promote clearance of secretions in the CF airway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	tyloxapol	tyloxapol	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	potentially	potentially	ADV	RB	_	_	_	_	_
7	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
11	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	CF	CF	PROPN	NNP	Number=Sing	_	_	_	_
15	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
16	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
20	possibly	possibly	ADV	RB	_	_	_	_	_
21	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
22	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	secretions	secretion	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CF	CF	PROPN	NNP	Number=Sing	_	_	_	_
28	airway	airway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1700
# text = Document 0030039 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030039	0030039	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1701
# text = The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	BCL6	Bcl6	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1702
# text = The chromosomal translocation involving 3q27 is often detected in human B-cell lymphomas, especially diffuse lymphomas with a large-cell component.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chromosomal	chromosomal	NOUN	NN	Number=Sing	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
5	3q27	3q27	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	often	often	ADV	RB	_	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	especially	especially	ADV	RB	_	_	_	_	_
17	diffuse	diffuse	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	large	large	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1703
# text = The BCL6 gene has been isolated from the chromosomal breakpoint in these lymphomas.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
3	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
10	breakpoint	breakpoint	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1704
# text = Here we cloned the murine BCL6 (mBCL6) cDNA from the muscle cDNA library using the human BCL6 (hBCL6) cDNA as a probe.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	cloned	clon	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
6	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	mBCL6	mBCL6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	_
14	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
15	library	library	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	BCL6	Bcl6	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	hBCL6	hBCL6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1705
# text = The predicted amino acid sequence was 95% identical to that of hBCL6.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	amino	amino	DET	DT	_	_	_	_	_
4	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	%	%	SYM	NN	Number=Sing	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	hBCL6	hbcl6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1706
# text = It contains six repeats of the Kruppel-like zinc-finger motif that are completely identical to those of hBCL6, indicating that the BCL6 gene is well conserved between humans and mice.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	six	six	NUM	CD	NumType=Card	_	_	_	_
4	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	completely	completely	ADV	RB	_	_	_	_	_
17	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	hBCL6	hBCL6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1707
# text = Expression of the mBCL6 gene was ubiquitously detected in adult mouse tissues including lymphatic organs.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mBCL6	mbcl6	PROPN	NNP	Number=Sing	_	_	_	_
5	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	lymphatic	lymphatic	ADJ	JJ	Degree=Pos	_	_	_	_
15	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1708
# text = Furthermore, it was induced in lymphocytes activated with phorbol ester and Ca2+ ionophore within 30 min after stimulation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Ca2	ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	+	+	SYM	SYM	_	_	_	_	_
15	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	30	30	NUM	CD	NumType=Card	_	_	_	_
18	min	min	NOUN	NNS	Number=Plur	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1709
# text = This induction was not inhibited by treatment of the cells with a protein synthesis inhibitor, cycloheximide.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1710
# text = These results suggest that BCL6 plays a role in activated lymphocytes as an immediate early gene.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
6	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1711
# text = Document 00300310 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300310	00300310	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1712
# text = Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
1	Differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	uncultured	uncultured	ADJ	JJ	Degree=Pos	_	_	_	_
36	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	lymphoma/	lymphomaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
45	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1713
# text = To determine activation status of the IL-2R-associated (Jak/STAT) pathway in the HTLV-I infected cells, we examined tyrosine phosphorylation of Jak3, STAT3, and STAT5 in several HTLV-I(+)
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	status	status	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL-	Il-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	2R-associated	2R-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Jak/	Jakith	X	ADD	_	_	_	_	SpaceAfter=No
11	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
35	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	+)	+)	SYM	NFP	_	_	_	_	_

# sent_id = 1714
# text = T-cell lines and in uncultured leukemic T cells isolated from patients with adult T-cell lymphoma/leukemia (ATLL).
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	uncultured	uncultured	ADJ	JJ	Degree=Pos	_	_	_	_
7	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lymphoma/leukemia	lymphoma/leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	ATLL	ATLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1715
# text = Constitutive basal phosphorylation of Jak3 and, usually, STAT3 and STAT5 was detected in all four IL-2-independent cell lines tested, but in none of the three IL-2-dependent cell lines.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	usually	usually	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	four	four	NUM	CD	NumType=Card	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-independent	-independent	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	tested	tested	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	none	none	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	three	three	NUM	CD	NumType=Card	_	_	_	_
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1716
# text = Similarly, there was no detectable basal phosphorylation of Jak3 and STAT5 in the leukemic cells from ATLL patients (0/8 and 0/3, respectively).
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	there	there	PRON	EX	_	_	_	_	_
4	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	ATLL	Atll	DET	DT	_	_	_	_	_
19	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	0/8	0/8	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	0/3	0/3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1717
# text = However, stimulation with IL-2 resulted in Jak3 and STAT5 phosphorylation in both leukemic ATLL cells and IL-2-dependent lines.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	ATLL	Atll	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1718
# text = Furthermore, expression of SHP-1 phosphatase which is a negative regulator of cytokine receptor signaling, was lost in most IL-2 independent cell lines (3/4) but not in the leukemic ATLL cells (0/3).
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	SHP	SHP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	3/	3/	SYM	SYM	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
38	ATLL	Atll	NOUN	NN	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	0/3	0/3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1719
# text = Finally, the HTLV-I(+)
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	+)	+)	SYM	NFP	_	_	_	_	_

# sent_id = 1720
# text = T-cell lines (313) but not the control, HTLV-I(-)
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	313	313	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	-)	-)	PUNCT	.	_	_	_	_	_

# sent_id = 1721
# text = T-cell lines were resistant to rapamycin and its novel analog RAD.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	rapamycin	rapamycin	VERB	VB	VerbForm=Inf	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
10	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	novel	novel	VERB	VB	VerbForm=Inf	_	_	_	_
12	analog	analog	ADJ	JJ	Degree=Pos	_	_	_	_
13	RAD	Rad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1722
# text = We conclude that (1) HTLV-I infection per se does not result in a constitutive phosphorylation of the Jak3, STAT3, and STAT5 proteins; (2) malignant transformation in at least some cases of ATLL does not require the constitutive, but may require IL-2-induced, activation of the IL-2R Jak/STAT pathway; and (3) there are major differences in T-cell immortalization mechanism(s) which appear to involve SHP-1 and target molecules for rapamycin and RAD.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	1	1	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	infection	infection	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	per	per	ADP	IN	_	_	_	_	_
12	se	se	NOUN	NN	Number=Sing	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	STAT5	STAT5	NOUN	NN	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	;	;	PUNCT	,	_	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	2	2	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
34	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	at	at	ADV	RB	_	_	_	_	_
37	least	least	ADV	RBS	Degree=Sup	_	_	_	_
38	some	some	DET	DT	_	_	_	_	_
39	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	ATLL	ATLL	NOUN	NN	Number=Sing	_	_	_	_
42	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	not	not	PART	RB	_	_	_	_	_
44	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	but	but	CCONJ	CC	_	_	_	_	_
49	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
50	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
51	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
63	Jak/	Jak/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
65	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	;	;	PUNCT	,	_	_	_	_	_
67	and	and	CCONJ	CC	_	_	_	_	_
68	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
69	3	3	X	LS	_	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	_
71	there	there	PRON	EX	_	_	_	_	_
72	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
73	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
74	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
75	in	in	ADP	IN	_	_	_	_	_
76	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
78	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
79	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
80	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
81	s	s	X	AFX	_	_	_	_	SpaceAfter=No
82	)	)	PUNCT	-RRB-	_	_	_	_	_
83	which	which	PRON	WDT	PronType=Rel	_	_	_	_
84	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
85	to	to	PART	TO	_	_	_	_	_
86	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
87	SHP	sHp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
89	1	1	NUM	CD	NumType=Card	_	_	_	_
90	and	and	CCONJ	CC	_	_	_	_	_
91	target	target	NOUN	NN	Number=Sing	_	_	_	_
92	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
93	for	for	ADP	IN	_	_	_	_	_
94	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
95	and	and	CCONJ	CC	_	_	_	_	_
96	RAD	Rad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
97	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1723
# text = Document 00300311 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300311	00300311	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1724
# text = Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	death	death	NOUN	NN	Number=Sing	_	_	_	_
6	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	autoinduction	autoinduction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1725
# text = In contrast to the negative autoregulation of glucocorticoid receptor (GR) expression seen in most cells and tissues, GR expression is positively autoregulated in human leukemic T cells and in other cells sensitive to glucocorticoid-induced cell death.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	positively	positively	ADV	RB	_	_	_	_	_
25	autoregulated	autoregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	sensitive	sensitive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1726
# text = To determine whether positive autoregulation is a necessary component of glucocorticoid-induced cell death, a wild-type GR gene under the control of a tetracycline-regulated promoter was stably transfected into glucocorticoid-resistant cells lacking endogenous functional receptor.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
22	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	under	under	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	control	control	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	tetracycline	tetracycline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	stably	stably	ADV	RB	_	_	_	_	_
34	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	into	into	ADP	IN	_	_	_	_	_
36	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
41	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
42	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
43	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1727
# text = Transfectants grown in the presence of tetracycline contained about 15,000 receptors/cell, a value approximately equal to basal level GR expression in glucocorticoid-sensitive 6TG1.1 cells before steroid treatment.
1	Transfectants	Transfectant	NOUN	NNS	Number=Plur	_	_	_	_
2	grown	grow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	tetracycline	tetracycline	NOUN	NN	Number=Sing	_	_	_	_
8	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	about	about	ADV	RB	_	_	_	_	_
10	15,000	15,000	NUM	CD	NumType=Card	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	value	value	NOUN	NN	Number=Sing	_	_	_	_
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
28	6TG1.1	6tg1.1	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	before	before	ADP	IN	_	_	_	_	_
31	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
32	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1728
# text = Under these conditions, dexamethasone had a minimal effect on cell growth, elicited little internucleosomal DNA fragmentation, and induced no cell cycle perturbation.
1	Under	under	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	dexamethasone	dexamethasone	PRON	NN	Number=Sing	_	_	_	_
6	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	elicited	elicit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
16	internucleosomal	internucleosomal	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	no	no	DET	DT	_	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	perturbation	perturbation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1729
# text = In the absence of tetracycline, GR mRNA and protein expression increased 2-3-fold, and cells expressed 48,000 receptors, a level nearly equivalent to that present in 6TG1.1 cells after 18 h of autoinduction.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tetracycline	tetracycline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	48,000	48,000	NUM	CD	NumType=Card	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	nearly	nearly	ADV	RB	_	_	_	_	_
28	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	18	18	NUM	CD	NumType=Card	_	_	_	_
37	h	h	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	autoinduction	autoinduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1730
# text = Under these conditions, dexamethasone markedly inhibited cell growth, caused G1 arrest, and induced significant internucleosomal DNA fragmentation.
1	Under	under	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	dexamethasone	dexamethasone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	markedly	markedly	ADV	RB	_	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	G1	G1	NUM	CD	NumType=Card	_	_	_	_
13	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
18	internucleosomal	internucleosomal	ADJ	JJ	Degree=Pos	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1731
# text = These studies therefore suggest that basal level GR expression is inadequate to mediate glucocorticoid-induced apoptosis in glucocorticoid-sensitive T cells and that positive autoregulation is a necessary component of this process.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	inadequate	inadequate	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
14	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
27	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
31	component	component	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1732
# text = Document 00300312 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300312	00300312	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1733
# text = Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors:
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
9	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
10	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1734
# text = a possible target for v-erbA oncogene action.
1	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
3	target	target	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	erbA	erbA	SYM	SYM	_	_	_	_	_
7	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
8	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1735
# text = The v-erbA oncogene, a mutated version of the thyroid hormone receptor alpha (c-erbA/TR-alpha), inhibits erythroid differentiation and constitutively represses transcription of certain erythrocyte genes, suggesting a normal function of the proto-oncogene c-erbA in erythropoiesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erbA	erba	PROPN	NNP	Number=Sing	_	_	_	_
4	oncogene	oncogene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	version	version	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
12	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	erbA/TR-alpha	erbA/TR-alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	represses	repress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
29	erythrocyte	erythrocyte	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
35	function	function	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
40	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	erythropoiesis	erythropoiesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1736
# text = Here we demonstrate that the endogenous thyroid hormone receptor alpha (c-erbA/TR-alpha) and the closely related retinoic acid receptor alpha (RAR-alpha) play a role in the regulation of normal erythroid differentiation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
8	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	c-	c-	X	GW	_	_	_	_	SpaceAfter=No
13	erbA/TR-	erbA/TR-	X	GW	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	closely	closely	ADV	RB	_	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	retinoic	retinoic	X	GW	_	_	_	_	_
21	acid	acid	X	GW	_	_	_	_	_
22	receptor	receptor	X	GW	_	_	_	_	_
23	alpha	alpha	X	GW	_	_	_	_	_
24	(	(	X	GW	_	_	_	_	SpaceAfter=No
25	RAR	Rar	X	GW	_	_	_	_	SpaceAfter=No
26	-	-	X	GW	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1737
# text = Retinoic acid (RA) distinctly modulated the erythroid differentiation program of normal erythroid progenitors and erythroblasts reversibly transformed by a conditional tyrosine kinase oncogene.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	distinctly	distinctly	ADV	RB	_	_	_	_	_
7	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	program	program	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
18	reversibly	reversibly	ADV	RB	_	_	_	_	_
19	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1738
# text = When added pulsewise to immature cells, differentiation was accelerated while more mature cells underwent premature cell death.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	pulsewise	pulsewise	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	accelerated	accelerated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	while	while	SCONJ	IN	_	_	_	_	_
12	more	more	ADV	RBR	_	_	_	_	_
13	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
16	premature	premature	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1739
# text = Thyroid hormone (T3) alone caused similar but weaker effects.
1	Thyroid	thyroid	ADJ	JJ	Degree=Pos	_	_	_	_
2	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	alone	alone	PRON	NN	Number=Sing	_	_	_	_
7	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	weaker	weaker	ADJ	JJ	Degree=Pos	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1740
# text = Interestingly, T3 strongly enhanced the action of RA, suggesting cooperative action of the two receptors in modulating erythroid differentiation.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	T3	T3	NUM	CD	NumType=Card	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	action	action	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
13	action	action	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1741
# text = Expression of the human RAR-alpha in receptor-negative erythroblasts conferred RA-induced regulation of differentiation to the otherwise unresponsive cells, thus showing that the RAR-alpha is essential for the RA effect.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	otherwise	otherwise	ADJ	JJ	Degree=Pos	_	_	_	_
23	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	thus	thus	ADV	RB	_	_	_	_	_
27	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
38	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1742
# text = Likewise, enhanced expression of exogenous c-erbA/TR-alpha in erythroblasts rendered them susceptible to modulation of differentiation by T3, suggesting a similar function of both receptors.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	erbA/TR-alpha	erbA/TR-alpha	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
11	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
13	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	_
27	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1743
# text = Document 00300319 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300319	00300319	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1744
# text = The internal methionine codons of human T-cell leukemia virus type II rex gene are not required for p24rex production or virus replication and transformation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
3	methionine	methionine	NOUN	NN	Number=Sing	_	_	_	_
4	codons	codon	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	p24rex	p24rex	NOUN	NN	Number=Sing	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
23	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1745
# text = Human T-cell leukemia virus types I (HTLV-I) and II (HTLV-II) have two nonstructural trans-acting regulatory genes, tax and rex, located in the 3' region of the viral genome.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	types	type	NOUN	NNS	Number=Plur	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	II	II	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	II	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	nonstructural	nonstructural	ADJ	JJ	Degree=Pos	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	rex	rex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	'	'	PUNCT	``	_	_	_	_	_
38	region	region	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
42	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1746
# text = The tax gene product (HTLV-I p40tax and HTLV-II p37tax) is the transcriptional activator of the viral long terminal repeat.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	p40	p40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	II	ii	NUM	CD	NumType=Card	_	_	_	_
15	p37tax	p37tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1747
# text = The rex gene encodes two protein products, p27rex/p21rex and p26rex/p24rex in HTLV-I and HTLV-II, respectively.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p27rex/	p27rex/	SYM	NFP	_	_	_	_	SpaceAfter=No
10	p21rex	p21rex	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p26rex/	p26rexith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
13	p24rex	p24rex	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	II	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1748
# text = Rex acts posttranscriptionally to facilitate accumulation of full-length gag/pol and singly spliced env mRNA in the cytoplasm of HTLV-infected cells.
1	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
2	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	posttranscriptionally	posttranscriptionally	ADV	RB	_	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
6	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	length	length	NOUN	NN	Number=Sing	_	_	_	_
11	gag	gag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	singly	singly	ADV	RB	_	_	_	_	_
16	spliced	splice	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	env	env	NOUN	NN	Number=Sing	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1749
# text = Previous studies showed that the first ATG of the rex gene is critical for Rex production and function.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	ATG	Atg	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1750
# text = The importance of the internal ATGs to Rex function is not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
6	ATGs	ATGs	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1751
# text = However, in vitro mutagenesis of the HTLV-I rex gene has provided indirect evidence which suggests that p21rex, and by analogy HTLV-II p24rex, results from initiation at an internal AUG of the tax/rex mRNA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	rex	rex	VERB	VB	VerbForm=Inf	_	_	_	_
12	gene	gene	PRON	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
16	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	p21rex	p21rex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	analogy	analogy	NOUN	NN	Number=Sing	_	_	_	_
25	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	II	ii	NUM	CD	NumType=Card	_	_	_	_
28	p24rex	p24rex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	results	result	NOUN	NNS	Number=Plur	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
36	AUG	Aug	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
42	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1752
# text = By using an infectious molecular clone of HTLV-II, we investigated the importance of the internal ATGs of the rex gene on Rex protein production and function.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
19	ATGs	ATGs	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1753
# text = Our results indicate that p24rex of HTLV-II is not initiated at an internal AUG and that the internal methionine codons are not crucial to the function of the rex gene and, ultimately, the transforming properties of the virus.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	p24rex	p24rex	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	II	II	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
16	AUG	Aug	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
21	methionine	methionine	NOUN	NN	Number=Sing	_	_	_	_
22	codons	codon	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	ultimately	ultimately	ADV	RB	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
39	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1754
# text = Document 00300320 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300320	00300320	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1755
# text = [Induction of apoptosis in lymphocytes by glucocorticoids: between physiology and pharmacology]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	physiology	physiology	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	pharmacology	pharmacology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1756
# text = Glucocorticoids are physiological molecules that are also extensively used in clinics as anti-inflammatory, immunosuppressive or anti-tumoral agents.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	extensively	extensively	ADV	RB	_	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	clinics	clinic	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	anti-tumoral	anti-tumoral	ADJ	JJ	Degree=Pos	_	_	_	_
18	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1757
# text = Glucocorticoids can induce apoptosis on normal lymphoid cells and play a key role in the physiology of thymic selection.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
4	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	physiology	physiology	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
19	selection	selection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1758
# text = In clinics these molecules are also used for their potencies in inducing apoptosis of malignant lymphoid cells.
1	In	in	ADP	IN	_	_	_	_	_
2	clinics	clinic	NOUN	NNS	Number=Plur	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	potencies	potency	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	inducing	induce	NOUN	NN	Number=Sing	_	_	_	_
13	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
16	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1759
# text = Glucocorticoids are mediating their effects after binding to an intracellular receptor belonging to the steroid receptor superfamily: the glucocorticoid receptor (GR).
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	mediating	mediat	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	after	after	SCONJ	IN	_	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1760
# text = Once activated, the GR, can mediate his effects through direct binding on the DNA or via protein/protein interactions with transcription factors.
1	Once	once	SCONJ	IN	_	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GR	Gr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
9	his	he	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1761
# text = Depending on the type of lymphocytes, the mechanism of apoptosis induced by glucocorticoids fall roughly in two categories: induction of "death genes" by the activated GR (I kappa B, c-jun) or repression of survival factors (AP-1, c-Myc).
1	Depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
15	fall	fall	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	roughly	roughly	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	categories	category	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
24	death	death	NOUN	NN	Number=Sing	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	"	"	PUNCT	''	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
43	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1762
# text = In the case of thymic selection the mechanism is more subtle depending on the mutual repression of Nur77 and GR.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	case	case	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
6	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
12	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mutual	mutual	ADJ	JJ	Degree=Pos	_	_	_	_
16	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Nur77	Nur77	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1763
# text = Document 00300324 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300324	00300324	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1764
# text = Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1765
# text = Cyclosporin A (CsA) exerts its immunosuppressive effect by inhibiting the activity of nuclear factor of activated T cells (NFAT), thus preventing transcriptional induction of several cytokine genes.
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
2	A	a	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	_
26	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1766
# text = This effect is thought to be largely mediated through inactivation of the phosphatase calcineurin, which in turn inhibits translocation of an NFAT component to the nucleus.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	largely	largely	ADV	RB	_	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
14	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	turn	turn	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
20	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
24	component	component	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1767
# text = Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	yields	yield	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	form	form	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
36	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1768
# text = Immunoblot analyses and metabolic labeling with [32P]orthophosphate show that CsA alters NFATp migration on SDS-polyacrylamide gel electrophoresis by increasing its phosphorylation level without affecting subcellular distribution.
1	Immunoblot	Immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
5	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	32P]	32P]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	orthophosphate	orthophosphate	ADJ	JJ	Degree=Pos	_	_	_	_
10	show	show	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
13	alters	alter	PROPN	NNPS	Number=Plur	_	_	_	_
14	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
15	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	SDS	SDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
20	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
21	electrophoresis	electrophoresis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	without	without	SCONJ	IN	_	_	_	_	_
28	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
29	subcellular	subcellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1769
# text = Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins.
1	Dephosphorylation	Dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
10	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
11	restores	restore	NOUN	NNS	Number=Plur	_	_	_	_
12	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
13	DNA	dna	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	reconstitute	reconstitute	VERB	VB	VerbForm=Inf	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1770
# text = These data point to a new mechanism for CsA-sensitive regulation of NFATp in which dephosphorylation is critical for DNA binding.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	point	point	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1771
# text = Document 00300327 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300327	00300327	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1772
# text = A mutation of the glucocorticoid receptor in primary cortisol resistance.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
10	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1773
# text = The precise molecular abnormalities that cause primary cortisol resistance have not been completely described.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	cause	cause	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
8	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
9	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1774
# text = In a subject with primary cortisol resistance we have observed glucocorticoid receptors (hGR) with a decreased affinity for dexamethasone.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	subject	subject	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
7	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	hGR	hGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1775
# text = We hypothesize that a mutation of the hGR glucocorticoid-binding domain is the cause of cortisol resistance.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesize	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hGR	hGR	PROPN	NNP	Number=Sing	_	_	_	_
9	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
18	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1776
# text = Total RNA isolated from the index subject's mononuclear leukocytes was used to produce first strand hGR cDNAs, and the entire hGR cDNA was amplified in segments and sequenced.
1	Total	total	PROPN	NNP	Number=Sing	_	_	_	_
2	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
3	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	index	index	NOUN	NN	Number=Sing	_	_	_	_
7	subject	subject	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
15	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	strand	strand	NOUN	NN	Number=Sing	_	_	_	_
17	hGR	hgr	ADP	IN	_	_	_	_	_
18	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
23	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
24	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	amplified	amplify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	sequenced	sequence	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1777
# text = At nucleotide 2,317 we identified a homozygous A for G point mutation that predicts an isoleucine (ATT) for valine (GTT) substitution at amino acid 729.
1	At	at	ADP	IN	_	_	_	_	_
2	nucleotide	nucleotide	ADV	RB	_	_	_	_	_
3	2,317	2,317	NUM	CD	NumType=Card	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	homozygous	homozygous	ADJ	JJ	Degree=Pos	_	_	_	_
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	G	G	ADJ	JJ	Degree=Pos	_	_	_	_
11	point	point	NOUN	NN	Number=Sing	_	_	_	_
12	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	predicts	predict	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	ATT	ATT	X	ADD	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	valine	valine	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GTT	GTT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	amino	amino	DET	DT	_	_	_	_	_
28	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
29	729	729	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1778
# text = When the wild-type hGR and hGR-Ile 729 were expressed in COS-1 cells and assayed for [3H]-Dexamethasone binding, the dissociation constants were 0.799 +/- 0.068 and 1.54 +/- 0.06 nM
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	hGR-	hGR-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	Ile	Ile	PROPN	NNP	Number=Sing	_	_	_	_
10	729	729	NUM	CD	NumType=Card	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
31	constants	constant	NOUN	NNS	Number=Plur	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	0.799	0.799	NUM	CD	NumType=Card	_	_	_	_
34	+/-	+/-	SYM	SYM	_	_	_	_	_
35	0.068	0.068	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	1.54	1.54	NUM	CD	NumType=Card	_	_	_	_
38	+/-	+/-	SYM	SYM	_	_	_	_	_
39	0.06	0.06	NUM	CD	NumType=Card	_	_	_	_
40	nM	nm	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1779
# text = (mean +/- SEM) (P < 0.01), respectively.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	mean	mean	X	GW	_	_	_	_	_
3	+/-	+/-	X	GW	_	_	_	_	_
4	SEM	SEm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	P	p	NOUN	NN	Number=Sing	_	_	_	_
8	<	<	PUNCT	-LRB-	_	_	_	_	_
9	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1780
# text = When the wild-type hGR and hGR-Ile 729 were expressed in CV-1 cells that were cotransfected with the mouse mammary tumor virus long terminal repeat fused to the chloramphenicol acetyl transferase (CAT) gene, the hGR-Ile 729 conferred a fourfold decrease in apparent potency on dexamethasone stimulation of CAT activity.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	hGR-	hGR-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	Ile	Ile	PROPN	NNP	Number=Sing	_	_	_	_
10	729	729	NUM	CD	NumType=Card	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	CV	CV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	long	long	ADV	RB	Degree=Pos	_	_	_	_
28	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
30	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
34	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
35	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	hGR-	hGR-	X	AFX	_	_	_	_	SpaceAfter=No
43	Ile	Ile	PROPN	NNP	Number=Sing	_	_	_	_
44	729	729	NUM	CD	NumType=Card	_	_	_	_
45	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	fourfold	fourfold	ADJ	JJ	Degree=Pos	_	_	_	_
48	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
51	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
52	on	on	ADP	IN	_	_	_	_	_
53	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
54	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
57	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1781
# text = The isoleucine for valine substitution at amino acid 729 impairs the function of the hGR and is the likely cause of primary cortisol resistance in this subject.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	valine	valine	NOUN	NN	Number=Sing	_	_	_	_
5	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	amino	amino	DET	DT	_	_	_	_	_
8	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
9	729	729	NUM	CD	NumType=Card	_	_	_	_
10	impairs	impair	NOUN	NNS	Number=Plur	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	hGR	hgr	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
20	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
24	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	subject	subject	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1782
# text = Document 00300340 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300340	00300340	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1783
# text = Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PML	pMl	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
10	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
13	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
18	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	erythropoiesis	erythropoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1784
# text = The expression of the PML gene was investigated in purified early hematopoietic progenitor cells (HPCs) induced to unilineage erythroid or granulocytic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	early	early	ADV	RB	Degree=Pos	_	_	_	_
12	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
13	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HPCs	HPC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	unilineage	unilineage	NOUN	NN	Number=Sing	_	_	_	_
21	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1785
# text = PML mRNA and protein, while barely detectable in quiescent HPCs, are consistently induced by growth factor stimulation through the erythroid or granulocytic lineage.
1	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	while	while	SCONJ	IN	_	_	_	_	_
7	barely	barely	ADV	RB	_	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
11	HPCs	HPC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	consistently	consistently	ADV	RB	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1786
# text = Thereafter, PML is downmodulated in late granulocytic maturation, whereas it is sustainably expressed through the erythroid pathway.
1	Thereafter	thereafter	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	downmodulated	downmodulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
8	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whereas	whereas	SCONJ	IN	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	sustainably	sustainably	ADV	RB	_	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1787
# text = In functional studies, PML expression was inhibited by addition of antisense oligomers targeting PML mRNA (alpha-PML).
1	In	in	ADP	IN	_	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	PML	PML	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
13	oligomers	oligomer	NOUN	NNS	Number=Plur	_	_	_	_
14	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
15	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
16	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	PML	pMl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1788
# text = Interestingly, early treatment (day 0 HPCs) with alpha-PML reduced the number of both erythroid and granulocytic colonies, whereas late treatment (day 5 culture) reduced erythroid, but not granulocytic, clonogenesis.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	day	day	NOUN	NN	Number=Sing	_	_	_	_
7	0	0	NUM	CD	NumType=Card	_	_	_	_
8	HPCs	HPC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
14	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	number	number	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	day	day	NOUN	NN	Number=Sing	_	_	_	_
29	5	5	NUM	CD	NumType=Card	_	_	_	_
30	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	ADV	RB	_	_	_	_	_
37	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	clonogenesis	clonogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1789
# text = These findings suggest that PML is required for early hematopoiesis and erythroid, but not granulocytic maturation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1790
# text = The pattern of PML expression in normal hematopoiesis mimics that of retinoblastoma pRb 105.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PML	pMl	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
9	mimics	mimics	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
13	pRb	pRb	NOUN	NN	Number=Sing	_	_	_	_
14	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1791
# text = Combined treatment of HPCs with alpha-PML and alpha-Rb oligomers inhibited both PML and Rb protein expression and completely blocked erythroid colony development.
1	Combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HPCs	HPC	PROPN	NNPS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
13	oligomers	oligomer	NOUN	NNS	Number=Plur	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	completely	completely	ADV	RB	_	_	_	_	_
23	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
25	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1792
# text = Furthermore, PML and pRb 105 were co-immunoprecipitated in cellular lysates derived from erythroid precursors indicating that this functional interaction may have a biochemical basis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	pRb	pRb	PROPN	NNP	Number=Sing	_	_	_	_
6	105	105	NUM	CD	NumType=Card	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	co-immunoprecipitated	co-immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
16	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
25	basis	basis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1793
# text = These results suggest a key functional role of PML in early hematopoiesis and late erythropoiesis: the latter phenomenon may be related to the molecular and functional interaction of PML with pRb 105.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PML	pMl	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
15	erythropoiesis	erythropoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
19	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	PML	pMl	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	pRb	pRb	NOUN	NN	Number=Sing	_	_	_	_
33	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1794
# text = Document 00300346 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300346	00300346	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1795
# text = Glucocorticoid receptors in anorexia nervosa and Cushing's disease.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	anorexia	anorexia	PROPN	NNP	Number=Sing	_	_	_	_
5	nervosa	nervosa	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1796
# text = BACKGROUND: Patients with anorexia nervosa do not display cushingoid features in spite of elevated cortisol plasma levels.
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
6	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	_
7	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	display	display	VERB	VB	VerbForm=Inf	_	_	_	_
10	cushingoid	cushingoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
17	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1797
# text = Whether a cortisol resistance or a reduced availability of the metabolic substrates necessary to develop the effect of glucocorticoids is responsible for this has not been established.
1	Whether	whether	SCONJ	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	metabolic	metabolic	NOUN	NN	Number=Sing	_	_	_	_
12	substrates	substrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1798
# text = METHODS: Twenty-two patients with severe restrictive anorexia nervosa, 10 patients with active Cushing's disease, and 24 healthy volunteers without psychiatric disorders or mood alterations were investigated.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Twenty	twenty	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
9	restrictive	restrictive	ADJ	JJ	Degree=Pos	_	_	_	_
10	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
11	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	Cushing	Cushing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	's	's	PART	POS	_	_	_	_	_
19	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	24	24	NUM	CD	NumType=Card	_	_	_	_
23	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
24	volunteers	volunteer	NOUN	NNS	Number=Plur	_	_	_	_
25	without	without	ADP	IN	_	_	_	_	_
26	psychiatric	psychiatric	ADJ	JJ	Degree=Pos	_	_	_	_
27	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	mood	mood	NOUN	NN	Number=Sing	_	_	_	_
30	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1799
# text = Glucocorticoid receptor characteristics were examined on mononuclear leukocytes by measuring [3H]dexamethasone binding and the effect of dexamethasone on [3H]thymidine incorporation, which represents an index of DNA synthesis.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	measuring	measure	VERB	VBG	VerbForm=Ger	_	_	_	_
11	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	H]	H]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
27	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	index	index	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
35	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1800
# text = RESULTS: The number of glucocorticoid receptors on mononuclear leukocytes (MNL) was comparable in patients with anorexia nervosa, patients with active Cushing's disease, and normal subjects (binding capacity 3.3 +/- 0.23 vs. 3.7 +/- 0.30 and 3.5 +/- 0.20 fmol/10(6) cells).
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	number	number	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
20	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	Cushing	Cushing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	's	's	PART	POS	_	_	_	_	_
27	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
35	3.3	3.3	NUM	CD	NumType=Card	_	_	_	_
36	+/-	+/-	SYM	SYM	_	_	_	_	_
37	0.23	0.23	NUM	CD	NumType=Card	_	_	_	_
38	vs.	vs.	ADP	IN	_	_	_	_	_
39	3.7	3.7	NUM	CD	NumType=Card	_	_	_	_
40	+/-	+/-	SYM	SYM	_	_	_	_	_
41	0.30	0.30	NUM	CD	NumType=Card	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	3.5	3.5	NUM	CD	NumType=Card	_	_	_	_
44	+/-	+/-	SYM	SYM	_	_	_	_	_
45	0.20	0.20	NUM	CD	NumType=Card	_	_	_	_
46	fmol/10	fmol/10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1801
# text = Conversely, glucocorticoid receptor affinity was significantly decreased in anorexia nervosa as well as in Cushing's patients compared to control subjects (dissociation constant 4.0 +/- 0.31 and 4.1 +/- 0.34 vs. 2.9 +/- 0.29 nmol/L, p < .001) and inversely correlated with the levels of urinary free cortisol in both groups of patients.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	significantly	significantly	ADV	RB	_	_	_	_	_
8	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
11	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	's	's	PART	POS	_	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
19	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
22	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
25	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
26	4.0	4.0	NUM	CD	NumType=Card	_	_	_	_
27	+/-	+/-	SYM	SYM	_	_	_	_	_
28	0.31	0.31	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	4.1	4.1	NUM	CD	NumType=Card	_	_	_	_
31	+/-	+/-	SYM	SYM	_	_	_	_	_
32	0.34	0.34	NUM	CD	NumType=Card	_	_	_	_
33	vs.	vs.	ADP	IN	_	_	_	_	_
34	2.9	2.9	NUM	CD	NumType=Card	_	_	_	_
35	+/-	+/-	SYM	SYM	_	_	_	_	_
36	0.29	0.29	NUM	CD	NumType=Card	_	_	_	_
37	nmol/L	nmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	p	p	NOUN	NN	Number=Sing	_	_	_	_
40	<	<	PUNCT	-LRB-	_	_	_	_	_
41	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	inversely	inversely	ADV	RB	_	_	_	_	_
45	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
51	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
52	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	both	both	DET	DT	_	_	_	_	_
55	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1802
# text = Basal [3H]thymidine incorporation in MNL was significantly reduced in anorexia nervosa as well as in Cushing's patients compared to control subjects (p < .001) and was diminished by dexamethasone to an extent similar to control subjects in patients with anorexia nervosa, but significantly (p < .001) less in those with Cushing's disease.
1	Basal	Basal	PROPN	NNP	Number=Sing	_	_	_	_
2	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
7	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
15	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	's	's	PART	POS	_	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
26	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	p	p	NOUN	NN	Number=Sing	_	_	_	_
29	<	<	PUNCT	-LRB-	_	_	_	_	_
30	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
40	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
43	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
48	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	but	but	CCONJ	CC	_	_	_	_	_
51	significantly	significantly	ADV	RB	_	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	p	p	NOUN	NN	Number=Sing	_	_	_	_
54	<	<	PUNCT	-LRB-	_	_	_	_	_
55	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
60	with	with	ADP	IN	_	_	_	_	_
61	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	's	's	PART	POS	_	_	_	_	_
63	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1803
# text = In patients with anorexia nervosa, the incorporation of [3H]thymidine into the MNL was inversely correlated with urinary free cortisol levels.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
5	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	3H]	3H]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	MNL	Mnl	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	inversely	inversely	ADV	RB	_	_	_	_	_
18	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
21	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
22	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1804
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1805
# text = These data indicate that the lack of cushingoid features in patients with anorexia nervosa is not ascribable to a reduced sensitivity to glucocorticoids but is more likely due to the paucity of metabolic substrates.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cushingoid	cushingoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
14	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	ascribable	ascribable	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	more	more	ADV	RBR	_	_	_	_	_
27	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
28	due	due	ADP	IN	_	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	paucity	paucity	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
34	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1806
# text = Document 00300349 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300349	00300349	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1807
# text = Genes that regulate interleukin-4 expression in T cells.
1	Genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1808
# text = Interleukin-4 is an immunomodulatory cytokine which plays a central role in the regulation of allergic and atopic immune responses.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1809
# text = Significant progress has been made in gaining a detailed understanding of the transcriptional regulation of the interleukin-4 gene.
1	Significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
2	progress	progress	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	made	make	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	SCONJ	IN	_	_	_	_	_
7	gaining	gain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	detailed	detailed	ADJ	JJ	Degree=Pos	_	_	_	_
10	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1810
# text = The recent identification and characterization of several key transcription factors has helped to elucidate the molecular mechanisms of T helper cell cytokine gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
8	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	helped	help	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1811
# text = Document 00300354 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300354	00300354	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1812
# text = Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines.
1	Extracellular	Extracelular	ADJ	JJ	Degree=Pos	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	ERK	ERK	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	target	target	NOUN	NN	Number=Sing	_	_	_	_
18	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	727	727	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1813
# text = STAT3 (signal transducer and activator of transcription 3) is a latent transcription factor that is activated by tyrosine phosphorylation (Tyr-705) in cells stimulated with cytokines or growth factors.
1	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Tyr	Tyr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	705	705	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1814
# text = Recent studies suggest that one or more cytoplasmic serine kinases also phosphorylate STAT3 and are necessary for maximal gene activation.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
10	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	phosphorylate	phosphorylate	ADJ	JJ	Degree=Pos	_	_	_	_
13	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1815
# text = Here we demonstrate, with a site-specific antibody, that STAT3 is phosphorylated on Ser-727 in human neutrophils stimulated with chemotactic factors (N-formyl-methionyl-leucyl-phenylalanine and complement C5a), cytokines [granulocyte/macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF)], or a protein kinase C activator (PMA).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	Ser-727	Ser-727	NUM	CD	NumType=Card	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	N-formyl-methionyl-leucyl-phenylalanine	N-formyl-methionyl-leucyl-phenylalanine	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	complement	complement	ADJ	JJ	Degree=Pos	_	_	_	_
29	C5a	C5a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
33	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
37	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
48	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
51	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	or	or	CCONJ	CC	_	_	_	_	_
59	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
60	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
61	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
62	C	c	NOUN	NN	Number=Sing	_	_	_	_
63	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
64	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
65	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1816
# text = (2-Amino-3'-methoxyphenyl)oxanaphthalen-4-one (PD 98059), an inhibitor of extracellular signal-regulated protein kinase (ERK) activation, blocked the serine phosphorylation of STAT3 induced by chemotactic factors or PMA.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Amino	Amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	methoxyphenyl	methoxyphenyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	oxanaphthalen	oxanaphthal	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PD	P	NOUN	NN	Number=Sing	_	_	_	_
18	98059	98059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
38	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
41	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
44	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
45	or	or	CCONJ	CC	_	_	_	_	_
46	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1817
# text = The drug was less effective on cytokines: it virtually abolished the response to GM-CSF that occurred 5 min after stimulation but only partly decreased those at 15-30 min and did not appreciably alter responses to G-CSF regardless of incubation time.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
5	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
10	virtually	virtually	ADV	RB	_	_	_	_	_
11	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	_
21	min	min	NOUN	NNS	Number=Plur	_	_	_	_
22	after	after	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	only	only	ADV	RB	_	_	_	_	_
26	partly	partly	ADV	RB	_	_	_	_	_
27	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	30	30	NUM	CD	NumType=Card	_	_	_	_
33	min	min	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	appreciably	appreciably	ADV	RB	_	_	_	_	_
38	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
39	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
43	regardless	regardless	ADV	RB	_	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
46	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1818
# text = 1-(5-Isoquinolinylsulphonyl)-2-methylpiperazine dihydrochloride
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-Isoquinolinylsulphonyl	-Isoquinolinylsulphonyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-methylpiperazine	-methylpiperazine	NOUN	NN	Number=Sing	_	_	_	_
9	dihydrochloride	dihydrochloride	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1819
# text = (H7), an inhibitor of a putative STAT3 serine kinase, and 4-(4-fluorophenyl)-2-(4-methylsulphinylphenyl)-5-(4-pyridyl) 1H-imidazole (SB 203580), an inhibitor of p38 mitogen-activated protein (MAP) kinase, did not dampen any of these serine phosphorylation responses.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	H7	H7	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
10	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
11	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-fluorophenyl	-fluorophenyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)-	)-	PUNCT	.	_	_	_	_	SpaceAfter=No
21	2-(	2-(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	4-methylsulphinylphenyl)-	4-methylsulphinylphenyl)-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-pyridyl	-pyridyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	1H	1h	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
29	-imidazole	-imidazole	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	SB	Sb	NOUN	NN	Number=Sing	_	_	_	_
32	203580	203580	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	p38	p38	NUM	CD	NumType=Card	_	_	_	_
39	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	not	not	PART	RB	_	_	_	_	_
50	dampen	dampen	VERB	VB	VerbForm=Inf	_	_	_	_
51	any	any	DET	DT	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
55	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
56	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1820
# text = We propose that neutrophils use both ERK-dependent and ERK-independent pathways to phosphorylate Ser-727 on STAT3.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
5	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	ERK	ERK	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-independent	-independent	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
16	Ser-727	Ser-727	NUM	CD	NumType=Card	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1821
# text = The former pathway is recruited by all ERK-activating stimuli, whereas the latter pathway uses an undefined serine kinase and is recruited selectively by cytokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	former	former	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	ERK-	ERK-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	_
19	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	selectively	selectively	ADV	RB	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1822
# text = Document 00300356 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300356	00300356	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1823
# text = Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-IL6 and NF-kappa B) which are involved in IL-6 regulation.
1	Effects	Effects	PROPN	NNPS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	6	6	NUM	CD	NumType=Card	_	_	_	_
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1824
# text = Interleukin-10 (IL-10), like IL-4, is known to inhibit cytokine expression in activated human monocytes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	like	like	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1825
# text = We showed that both IL-10 and IL-4 inhibit LPS-induced IL-6 mRNA and protein expression by inhibiting the transcription rate of the IL-6 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
13	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1826
# text = The strong inhibition of the IL-6 transcription rate prompted us to study the effect of IL-10 and IL-4 on the expression of transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
11	prompted	prompt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1827
# text = We questioned whether or not IL-10 and IL-4 affected the expression of transcription factors that are known to be involved in the control of the IL-6 transcription rate, namely activator protein-1 (AP-1), nuclear factor IL-6 (NF-IL6), and nuclear factor kappa B (NF-kappaB).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	questioned	question	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	control	control	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	namely	namely	ADV	RB	_	_	_	_	_
37	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
48	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
49	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	6	6	NUM	CD	NumType=Card	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
60	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
61	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
62	B	b	PROPN	NNP	Number=Sing	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1828
# text = In electrophoretic mobility shift assays (EMSAs) we showed that IL-10 and IL-4 inhibited LPS-induced AP-1 binding activity.
1	In	in	ADP	IN	_	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1829
# text = The inhibiting effect of IL-4 was slightly more pronounced than that of IL-10.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibiting	inhibit	NOUN	NN	Number=Sing	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	slightly	slightly	ADV	RB	_	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	pronounced	pronounced	ADJ	JJ	Degree=Pos	_	_	_	_
12	than	than	ADP	IN	_	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1830
# text = Downregulation of LPS-induced AP-1 was accompanied, and thus possibly explained, by a reduced expression at mRNA level of the two major components of the AP-1 complex, namely c-fos and c-jun as determined by Northern experiments.
1	Downregulation	Downregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	accompanied	accompanied	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	thus	thus	ADV	RB	_	_	_	_	_
14	possibly	possibly	ADV	RB	_	_	_	_	_
15	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	two	two	NUM	CD	NumType=Card	_	_	_	_
27	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
28	components	component	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	namely	namely	ADV	RB	_	_	_	_	_
37	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
41	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
42	as	as	SCONJ	IN	_	_	_	_	_
43	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
46	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1831
# text = Binding activity of NF-IL6 was also strongly inhibited by IL-4 whereas IL-10 showed no effect.
1	Binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	strongly	strongly	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	10	10	NUM	CD	NumType=Card	_	_	_	_
19	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	no	no	DET	DT	_	_	_	_	_
21	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1832
# text = NF-IL6 mRNA levels were not affected by IL-10 or IL-4, suggesting that IL-4 affects binding activity of preexisting NF-IL6.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	affects	affect	NOUN	NNS	Number=Plur	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	SCONJ	IN	_	_	_	_	_
27	preexisting	preexist	VERB	VBG	VerbForm=Ger	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1833
# text = Neither IL-10 nor IL-4 inhibited LPS-induced NF-kappa B binding activity.
1	Neither	neither	DET	DT	_	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	nor	nor	NOUN	NN	Number=Sing	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1834
# text = In agreement with this finding, Northern experiments where p65 and p105 mRNA levels were determined, demonstrated that expression of these components of the NF-kappa B transcription factor were not affected by IL-10 or IL-4.
1	In	in	ADP	IN	_	_	_	_	_
2	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	finding	finding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
9	where	where	ADV	WRB	PronType=Rel	_	_	_	_
10	p65	p65	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p105	p105	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	components	component	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	10	10	NUM	CD	NumType=Card	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1835
# text = Furthermore, neither IL-10 nor IL-4 showed any effect on
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	neither	neither	DET	DT	_	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	nor	nor	NOUN	NN	Number=Sing	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	any	any	DET	DT	_	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_

# sent_id = 1836
# text = I-kappa B mRNA expression as determined by Northern experiments.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	-	-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
3	kappa	kappa	X	GW	_	_	_	_	_
4	B	b	X	GW	_	_	_	_	_
5	mRNA	mRNa	X	GW	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	SCONJ	IN	_	_	_	_	_
8	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
11	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1837
# text = Thus, IL-10 and IL-4 similarly affect IL-6 expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	similarly	similarly	ADJ	JJ	Degree=Pos	_	_	_	_
11	affect	affect	NOUN	NN	Number=Sing	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1838
# text = However, for IL-4 this was accompanied with a reduction of AP-1 and NF-IL6 binding activity whereas IL-10 only inhibited AP-1 binding activity.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	whereas	whereas	NOUN	NNS	Number=Plur	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1839
# text = Document 00300363 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300363	00300363	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1840
# text = Thyroid hormone receptors form distinct nuclear protein-dependent and independent complexes with a thyroid hormone response element.
1	Thyroid	thyroid	ADJ	JJ	Degree=Pos	_	_	_	_
2	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	form	form	ADP	IN	Typo=Yes	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
15	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1841
# text = We have examined the binding of nuclear proteins and recombinant thyroid hormone receptors (TRs) to the palindromic thyroid hormone responsive element AGGTCATGACCT (TREp) using a gel electrophoretic mobility shift assay.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
11	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
12	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TRs	TRs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
20	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
21	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	AGGTCATGACCT	AGGTCATGACCT	PROPN	NNP	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TREp	TREp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
33	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
34	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1842
# text = Four specific protein-DNA complexes were detected after incubation of nuclear extracts (NE) from T3-responsive pituitary (GH3) cells with a TREp-containing DNA fragment.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NE	NE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
21	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GH3	GH3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	TREp	TREp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1843
# text = This was compared with the TREp binding of reticulocyte lysate-synthesized TRs.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TREp	TREp	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
10	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	TRs	TR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1844
# text = TR alpha 1 and TR beta 2 each formed a single major TR:TREp complex which comigrated with the least retarded complex formed by GH3 NE, while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer.
1	TR	Tr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	alpha	alpha	ADV	RB	_	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	TR	Tr	ADJ	JJR	Degree=Cmp	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	each	each	DET	DT	_	_	_	_	_
9	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
12	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
13	TR:	Tr:	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	TREp	TREp	NOUN	NN	Number=Sing	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	comigrated	comigrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	least	least	ADJ	JJS	Degree=Sup	_	_	_	_
21	retarded	retard	ADJ	JJ	Degree=Pos	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	GH3	GH3	NOUN	NN	Number=Sing	_	_	_	_
26	NE	Ne	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	while	while	SCONJ	IN	_	_	_	_	_
29	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
30	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
34	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
35	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
38	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
39	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	TREp	TREp	VERB	VB	VerbForm=Inf	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1845
# text = Interestingly, coincubation of 35S-TR alpha 1, GH3 NE, and unlabeled TREp resulted in not only the 35S-TR:TREp complex, but in two additional more greatly retarded complexes containing 35S-TR alpha 1 and comigrating with those formed by GH3 extract alone.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	coincubation	coincubation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	35S	35S	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	GH3	GH3	NUM	CD	NumType=Card	_	_	_	_
12	NE	NE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	unlabeled	unlabel	ADJ	JJ	Degree=Pos	_	_	_	_
16	TREp	TREp	PROPN	NNP	Number=Sing	_	_	_	_
17	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	35S	35S	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	TR:TREp	TR:TREp	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	greatly	greatly	ADV	RB	_	_	_	_	_
33	retarded	retarded	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
35	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
36	35S	35S	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
39	alpha	alpha	ADP	IN	_	_	_	_	_
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	comigrating	comigrat	VERB	VBG	VerbForm=Ger	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
45	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	GH3	GH3	NUM	CD	NumType=Card	_	_	_	_
48	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
49	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1846
# text = Incubation of each of the TRs with NE from COS-7 cells, which do not possess sufficient endogenous TRs to mediate T3-responses, resulted in formation of a new, more greatly shifted complex.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	each	each	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TRs	TRs	PROPN	NNPS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	NE	NE	PROPN	NNP	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	7	7	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	possess	possess	VERB	VB	VerbForm=Inf	_	_	_	_
19	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
20	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
21	TRs	TR	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
24	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	more	more	ADV	RBR	_	_	_	_	_
36	greatly	greatly	ADV	RB	_	_	_	_	_
37	shifted	shifte	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1847
# text = A similar, heat labile activity which altered mobility of the TR:TRE complex was also present in NE from T3-unresponsive JEG-3 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
5	labile	labile	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	altered	alter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TR:	Tr:	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	NE	NE	PROPN	NNP	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
24	JEG	JEG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1848
# text = At high concentration of NE, all of the TR bound to TREp was more greatly retarded than in the absence of NE.
1	At	at	ADP	IN	_	_	_	_	_
2	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
3	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NE	Ne	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
11	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	TREp	TREp	PROPN	NNP	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	greatly	greatly	ADV	RB	_	_	_	_	_
17	retarded	retard	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NE	NE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1849
# text = Truncation of TR alpha 1 at amino acid 210 prevented additional complex formation in the presence of NE without affecting DNA binding, suggesting that the carboxyl-terminus of the TRs is essential for interaction with nuclear proteins.
1	Truncation	Truncation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	amino	amino	DET	DT	_	_	_	_	_
8	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
9	210	210	NUM	CD	NumType=Card	_	_	_	_
10	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NE	NE	PROPN	NNP	Number=Sing	_	_	_	_
19	without	without	SCONJ	IN	_	_	_	_	_
20	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	TRs	TRs	NOUN	NNS	Number=Plur	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1850
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1851
# text = Document 00300368 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300368	00300368	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1852
# text = Megakaryocytic and erythrocytic lineages share specific transcription factors.
1	Megakaryocytic	Megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
5	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1853
# text = Erythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage.
1	Erythroid	Erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	also	also	ADV	RB	_	_	_	_	_
14	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	GF	gf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Eryf	Eryf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	refs	ref	NOUN	NNS	Number=Plur	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	principal	principal	ADJ	JJ	Degree=Pos	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
39	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1854
# text = NF-E1 expression seems to be restricted to the erythrocytic lineage.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1855
# text = A closely related (if not identical) protein is found in both a human megakaryocytic cell line and purified human megakaryocytes; it binds to promoter regions of two megakaryocytic-specific genes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	closely	closely	ADV	RB	_	_	_	_	_
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	if	if	SCONJ	IN	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	purified	purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
28	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1856
# text = The binding sites and partial proteolysis profile of this protein are indistinguishable from those of the erythroid protein; also, NF-E1 messenger RNA is the same size in both the megakaryocytic and erythroid cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
6	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
7	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
25	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
26	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
30	size	size	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	both	both	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1857
# text = Furthermore, point mutations that abolish binding of NF-E1 result in a 70% decrease in the transcriptional activity of a megakaryocytic-specific promoter.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	point	point	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	abolish	abolish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	E1	e1	PROPN	NNP	Number=Sing	_	_	_	_
12	result	result	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1858
# text = We also find that NF-E2, another trans-acting factor of the erythrocytic lineage, is present in megakaryocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	another	another	DET	DT	_	_	_	_	_
10	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1859
# text = Transcriptional effects in both lineages might then be mediated in part by the same specific trans-acting factors.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
6	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
7	then	then	ADV	RB	PronType=Dem	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	part	part	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1860
# text = Our data strengthen the idea of a close association between the erythrocytic and the megakaryocytic lineages and could also explain the expression of markers specific to the erythrocytic and megakaryocytic lineages in most erythroblastic and megakaryoblastic permanent cell lines.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	strengthen	strengthan	ADP	IN	Typo=Yes	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	idea	idea	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
9	association	association	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADV	RB	_	_	_	_	_
33	most	most	ADV	RBS	_	_	_	_	_
34	erythroblastic	erythroblastic	ADJ	JJ	Degree=Pos	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
37	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1861
# text = Document 00300370 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300370	00300370	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1862
# text = Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	ADP	IN	_	_	_	_	_
5	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	increases	increase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	dexamethasone	dexamethasone	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1863
# text = Resistance to glucocorticoid therapy has been observed in patients with autoimmune/inflammatory diseases and may be related to the inflammatory process itself.
1	Resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	autoimmune	autoimmune	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	process	process	NOUN	NN	Number=Sing	_	_	_	_
23	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1864
# text = The aim of this study was to examine the ability of tumor necrosis factor alpha (TNFalpha, a proinflammatory cytokine) and interleukin (IL)-10 (an anti-inflammatory cytokine) to differentially regulate the sensitivity of human monocytes/macrophages to glucocorticoids.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
13	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	differentially	differentially	ADV	RB	_	_	_	_	_
37	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1865
# text = To accomplish this, we first analyzed the pattern of TNFalpha and IL-10 inhibition by dexamethasone in LPS-stimulated whole-blood cell cultures.
1	To	to	PART	TO	_	_	_	_	_
2	accomplish	accomplish	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	first	first	ADV	RB	_	_	_	_	_
7	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	10	10	NUM	CD	NumType=Card	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1866
# text = Second, we studied the modulation of the sensitivity of these cells to dexamethasone by preincubation with TNFalpha or IL-10 and measurement of LPS-stimulated IL-6 secretion.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	dexamethasone	dexamethasone	VERB	VB	VerbForm=Inf	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	10	10	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	measurement	measurement	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	_
32	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1867
# text = In addition, we evaluated the effect of dexamethasone on phorbolmyristate-acetate-stimulated IL-1 receptor antagonist secretion by the human monocytic cell line U937.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	phorbolmyristate-acetate-stimulated	phorbolmyristate-acetate-stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1868
# text = Finally, we investigated whether the modulation of corticosensitivity in TNFalpha- and IL-10-pretreated U937 cells was related to a change of the glucocorticoid receptor concentration and affinity.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	corticosensitivity	corticosensitivity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	U937	U937	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	change	change	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1869
# text = Dexamethasone had different effects on LPS-induced TNFalpha and IL-10 secretion; whereas it suppressed TNFalpha in a dose-dependent fashion, its effect on IL-10 secretion was biphasic, producing stimulation at lower, and inhibition at higher doses.
1	Dexamethasone	Dexamethasone	PRON	NN	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
28	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	10	10	NUM	CD	NumType=Card	_	_	_	_
34	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
39	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
40	at	at	ADP	IN	_	_	_	_	_
41	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
45	at	at	ADP	IN	_	_	_	_	_
46	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
47	doses	dos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1870
# text = The concentration of LPS employed influenced the effect of dexamethasone on IL-10 secretion (P < 0.001).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
5	employed	employ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	influenced	influence	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	<	<	PUNCT	-LRB-	_	_	_	_	_
19	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1871
# text = Pretreatment with TNFalpha diminished, and with IL-10 improved, the ability of dexamethasone to suppress IL-6 secretion in whole-blood cell cultures (P < 0.01 for both) and to enhance IL-1 receptor antagonist secretion by U937 cells (P < 0.05 for both).
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	improved	improve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	P	p	NOUN	NN	Number=Sing	_	_	_	_
31	<	<	PUNCT	-LRB-	_	_	_	_	_
32	0.01	0.01	NUM	CD	NumType=Card	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	both	both	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
44	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	U937	U937	NUM	CD	NumType=Card	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	P	p	NOUN	NN	Number=Sing	_	_	_	_
50	<	<	PUNCT	-LRB-	_	_	_	_	_
51	0.05	0.05	NUM	CD	NumType=Card	_	_	_	_
52	for	for	ADP	IN	_	_	_	_	_
53	both	both	DET	DT	_	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1872
# text = TNFalpha decreased (P < 0.001), while IL-10 increased (P < 0.001), the concentration of dexamethasone binding sites in these cells, with no discernible effect on their binding affinity.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	decreased	decreased	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	P	p	NOUN	NN	Number=Sing	_	_	_	_
5	<	<	PUNCT	-LRB-	_	_	_	_	_
6	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	while	while	SCONJ	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	P	p	NOUN	NN	Number=Sing	_	_	_	_
16	<	<	PUNCT	-LRB-	_	_	_	_	_
17	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	no	no	DET	DT	_	_	_	_	_
32	discernible	discernible	ADJ	JJ	Degree=Pos	_	_	_	_
33	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
37	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1873
# text = We conclude that glucocorticoids differentially modulate TNFalpha and IL-10 secretion by human monocytes in a LPS dose-dependent fashion and that the sensitivity of these cells to glucocorticoids is altered by TNFalpha or IL-10 pretreatment; TNFalpha blocks their effects, whereas IL-10 acts synergistically with glucocorticoids.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
5	differentially	differentially	ADV	RB	_	_	_	_	_
6	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	10	10	NUM	CD	NumType=Card	_	_	_	_
12	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
19	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	10	10	NUM	CD	NumType=Card	_	_	_	_
40	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	;	;	PUNCT	,	_	_	_	_	_
42	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
43	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
44	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
45	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	whereas	whereas	SCONJ	IN	_	_	_	_	_
48	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	10	10	NUM	CD	NumType=Card	_	_	_	_
51	acts	acts	NOUN	NNS	Number=Plur	_	_	_	_
52	synergistically	synergistically	ADV	RB	_	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1874
# text = This is accompanied by opposite glucocorticoid receptor changes, respectively opposing and favoring glucocorticoid actions.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	respectively	respectively	ADV	RB	_	_	_	_	_
11	opposing	oppos	VERB	VBG	VerbForm=Ger	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	favoring	favor	VERB	VBG	VerbForm=Ger	_	_	_	_
14	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	actions	action	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1875
# text = This study suggests that the pattern of pro-/antiinflammatory cytokine secretion may alter the response of patients to glucocorticoid therapy.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	pro-/	pro-ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	_
20	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1876
# text = Document 00300379 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300379	00300379	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1877
# text = CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts.
1	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-mediated	-mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
4	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Porphyromonas	Porphyromonas	PROPN	NNP	Number=Sing	_	_	_	_
7	gingivalis	gingivalis	PROPN	NNP	Number=Sing	_	_	_	_
8	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1878
# text = Lipopolysaccharide (LPS) induces expression of inflammatory cytokines in monocytes/macrophages via CD14, one of the LPS receptors, which is expressed predominantly in these cells.
1	Lipopolysaccharide	Lipopolysaccharide	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
14	via	via	ADP	IN	_	_	_	_	_
15	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	predominantly	predominantly	ADV	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1879
# text = It has been demonstrated that Porphyromonas gingivalis LPS (P-LPS) also is able to induce inflammatory cytokines in human gingival fibroblasts.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	Porphyromonas	Porphyromonas	PROPN	NNP	Number=Sing	_	_	_	_
7	gingivalis	gingivalis	PROPN	NNP	Number=Sing	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
24	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1880
# text = Therefore, it is important to determine whether CD14 is expressed in gingival fibroblasts and to define the P-LPS-mediated signal-transducing mechanism in the cells.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	whether	whether	SCONJ	IN	_	_	_	_	_
9	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	gingival	gingival	ADJ	JJ	Degree=Pos	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	transducing	transducing	NOUN	NN	Number=Sing	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1881
# text = In this study, we observed unexpectedly by immunohistochemical, Western blotting (immunoblotting), and Northern (RNA) blotting assays that CD14 is expressed at high density in human gingival fibroblasts.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	unexpectedly	unexpectedly	ADV	RB	_	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	immunohistochemical	immunohistochemical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
12	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	blotting	blott	VERB	VBG	VerbForm=Ger	_	_	_	_
23	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	14	14	NUM	CD	NumType=Card	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	density	density	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
35	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1882
# text = P-LPS-induced expression of the monocyte chemoattractant protein 1 (MCP-1) gene in the cells was inhibited markedly by treatment with anti-human CD14 antibody and was completely inhibited by herbimycin A, a potent inhibitor of tyrosine kinase.
1	P-	P-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
2	LPS	LPS	X	GW	_	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
9	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	markedly	markedly	ADV	RB	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
28	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	14	14	NUM	CD	NumType=Card	_	_	_	_
30	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	completely	completely	ADV	RB	_	_	_	_	_
34	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
37	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
41	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
44	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1883
# text = The inhibitor also dramatically inhibited monocyte chemotactic activity of and MCP-1 production by the cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	dramatically	dramatically	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
7	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	MCP	MCP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1884
# text = Furthermore, P-LPS-induced expression of the MCP-1 gene in the cells also was blocked by inhibitors of two transcription factors, i.e., curcumin, an inhibitor of AP-1, and pyrolidine dithiocarbamate, an inhibitor of NF-kappaB.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	P-	P-	X	GW	_	_	_	_	SpaceAfter=No
4	LPS	LPS	X	GW	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	MCP	Mcp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	two	two	NUM	CD	NumType=Card	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	curcumin	curcumin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	pyrolidine	pyrolidine	NOUN	NN	Number=Sing	_	_	_	_
40	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1885
# text = Both inhibitors inhibited monocyte chemotactic activity in the culture supernatant of P-LPS-treated cells.
1	Both	both	DET	DT	_	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
5	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
10	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1886
# text = Gel shift mobility assay showed stimulation of the AP-1 and NF-kappaB contents in P-LPS-treated cells.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	contents	contents	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1887
# text = This study is the first to demonstrate the expression of CD14 in human gingival fibroblasts and to show that the signal-transducing pathway of P-LPS in the cells is mediated by CD14.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
16	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1888
# text = Document 00300384 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300384	00300384	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1889
# text = UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan.
1	UV	haUve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	CYP1A1	Cyp1a1	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1890
# text = Induction of cytochrome P-4501A1 (CYP1A1) activity by UV has been observed earlier in animal studies via a mechanism that has not yet been resolved.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytochrome	cytochrome	NOUN	NN	Number=Sing	_	_	_	_
4	P-4501A1	P-4501A1	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	CYP1	CYP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	A1	A1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
18	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	yet	yet	ADV	RB	_	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	resolved	resolve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1891
# text = Our previous data have indicated that formylated indolocarbazoles which are formed by UV irradiation of tryptophan solutions are very potent
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	formylated	formylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	indolocarbazoles	indolocarbazole	NOUN	NNS	Number=Plur	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
14	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	tryptophan	tryptophan	ADJ	JJ	Degree=Pos	_	_	_	_
17	solutions	solution	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	very	very	ADV	RB	_	_	_	_	_
20	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1892
# text = Ah-receptor agonists.
1	Ah	ah	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1893
# text = To evaluate the effect of UV light on cytochrome P4501A1 gene expression, we studied the induction of CYP1A1 mRNA by UV irradiation of cultured human keratinocytes (HaCaT cell line), primary human blood lymphocytes and mouse Hepa-1 cells.
1	To	to	PART	TO	_	_	_	_	_
2	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	UV	UV	NOUN	NN	Number=Sing	_	_	_	_
7	light	light	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	cytochrome	cytochrome	NOUN	NN	Number=Sing	_	_	_	_
10	P4501A1	P4501A1	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CYP1A1	CYP1A1	PROPN	NNP	Number=Sing	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
23	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	keratinocytes	keratinocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	HaCaT	Hacat	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
40	Hepa	Hepa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1894
# text = The cells were exposed to UV light delivered by a bank of 6 Philips TL20/12RS sun lamps emitting primarily in the UVB range in the absence and presence of tryptophan.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
7	light	light	NOUN	NN	Number=Sing	_	_	_	_
8	delivered	deliver	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	bank	bank	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	Philips	Philips	PROPN	NNP	Number=Sing	_	_	_	_
15	TL20/12RS	tl20/12rs	PROPN	NNP	Number=Sing	_	_	_	_
16	sun	sun	NOUN	NN	Number=Sing	_	_	_	_
17	lamps	lamp	NOUN	NNS	Number=Plur	_	_	_	_
18	emitting	emit	VERB	VBG	VerbForm=Ger	_	_	_	_
19	primarily	primarily	ADV	RB	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	UVB	uvb	PROPN	NNP	Number=Sing	_	_	_	_
23	range	range	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1895
# text = A semiquantitative reverse transcriptase-linked polymerase chain reaction (RT-PCR) was used for analysis of gene expression in the treated cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
3	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
4	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	PCR	Pcr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1896
# text = The results show that the CYP1A1 mRNA level induced by UV in the presence of tryptophan was higher than that induced by UV alone in both HaCaT cells and lymphocytes after 3 h of incubation post-UV irradiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CYP1A1	CYP1A1	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
24	alone	alone	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	_
27	HaCaT	Hacat	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	h	h	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
36	post	post	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	UV	uv	NOUN	NN	Number=Sing	_	_	_	_
39	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1897
# text = To find out if the induction by UV light is caused by the formation of an Ah receptor ligand, Hepa-1 wild-type and Ah receptor deficient c12 cell lines were applied.
1	To	to	PART	TO	_	_	_	_	_
2	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
3	out	out	ADP	RP	_	_	_	_	_
4	if	if	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
9	light	light	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Hepa	Hepa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	_
23	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	deficient	deficient	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	c12	c12	NUM	CD	NumType=Card	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1898
# text = Wild-type (wt) cells were inducible either by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) or by UV-irradiation but very low or undetectable levels were observed in the c12 cells.
1	Wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	type	type	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	wt	wt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	tryptophan	tryptophan	ADJ	JJ	Degree=Pos	_	_	_	_
14	photoproduct	photoproduct	NOUN	NN	Number=Sing	_	_	_	_
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	formylindolo	formylindolo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	[3	[3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	b]	b]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	carbazole	carbazole	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	FICZ	FICZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	UV	UV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	very	very	ADV	RB	_	_	_	_	_
34	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	c12	c12	NOUN	NN	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1899
# text = This shows that the induction of gene expression by FICZ and UV is Ah receptor dependent.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	FICZ	FICZ	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1900
# text = Together, these results indicate that UV-induced CYP1A1 gene expression in mammalian cells is mediated by an Ah receptor ligand formed from tryptophan.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	UV	uv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CYP1A1	Cyp1a1	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
23	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1901
# text = Thus, the photoproducts of tryptophan are suggested to be mediators of light via binding to the Ah receptor and as such also could have a role in light-regulated biological rhythms.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	photoproducts	photoproduct	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	light	light	NOUN	NN	Number=Sing	_	_	_	_
14	via	via	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
25	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	light	light	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
33	rhythms	rhythm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1902
# text = Document 00300385 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300385	00300385	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1903
# text = The Ah receptor recognizes DNA binding sites for the B cell transcription factor, BSAP: a possible mechanism for dioxin-mediated alteration of CD19 gene expression in human B lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	BSAP	Bsap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	dioxin-	dioxin-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	19	19	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	lymphocytes.	lymphocytes.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 1904
# text = 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inhibits murine and human B lymphocyte immunoglobulin production through an unknown mechanism.
1	2,3,7,8-tetrachlorodibenzo-p-dioxin	2,3,7,8-tetrachlorodibenzo-p-dioxin	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TCDD	tCDd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
11	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1905
# text = This study investigated the effect of TCDD on expression of the CD19 gene in a human B lymphocyte cell line.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TCDD	tCDd	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	19	19	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1906
# text = Northern blot analysis showed that TCDD treatment decreased steady state levels of CD19 mRNA by 67% in the IM-9 cell line.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	TCDD	TCDD	PROPN	NNP	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
10	state	state	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	19	19	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	67	67	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IM	Im	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	9	9	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1907
# text = Using a gel mobility shift assay, we identified a DNA-binding complex in IM-9 nuclear extracts that by several criteria appears to be the Ah receptor.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	IM	Im	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	9	9	NUM	CD	NumType=Card	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	criteria	criteria	NOUN	NN	Number=Sing	_	_	_	_
25	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1908
# text = In addition, the Ah receptor complex recognized a DNA binding site for B cell lineage-specific activator protein (BSAP) in the promoter region of the human CD19 gene which is similar to the consensus
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	recognized	recognize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	19	19	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1909
# text = Ah receptor DNA binding site.
1	Ah	ah	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1910
# text = These results suggest that the AhR could interfere with BSAP-stimulated CD19 gene transcription by competition for a common DNA binding site.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	AhR	Ahr	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	19	19	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1911
# text = Document 00300387 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300387	00300387	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1912
# text = Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations [see comments] BACKGROUND: Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis).
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	arsenic	arsenic	NOUN	NN	Number=Sing	_	_	_	_
12	trioxide	trioxide	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	clinically	clinically	ADV	RB	_	_	_	_	_
15	achievable	achievable	ADJ	JJ	Degree=Pos	_	_	_	_
16	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
19	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
21	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	:	:	PUNCT	:	_	_	_	_	_
23	Arsenic	arsenic	ADJ	JJ	Degree=Pos	_	_	_	_
24	trioxide	trioxide	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	As2	As2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	O3	O3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
31	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
32	remission	remission	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
37	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
39	via	via	ADP	IN	_	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	death	death	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1913
# text = We investigated the effects of As2O3 on a panel of malignant lymphocytes to determine whether growth-inhibitory and apoptotic effects of As2O3 can be observed in these cells at clinically achievable concentrations.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	As2O3	As2O3	NUM	CD	NumType=Card	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
15	whether	whether	SCONJ	IN	_	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	As2O3	As2O3	NOUN	NN	Number=Sing	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	clinically	clinically	ADV	RB	_	_	_	_	_
32	achievable	achievable	ADJ	JJ	Degree=Pos	_	_	_	_
33	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1914
# text = METHODS: Eight malignant lymphocytic cell lines and primary cultures of lymphocytic leukemia and lymphoma cells were treated with As2O3, with or without dithiothreitol (DTT) or buthionine sulfoximine (BSO) (an inhibitor of glutathione synthesis).
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Eight	eight	PROPN	NNP	Number=Sing	_	_	_	_
4	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
5	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	As2O3	As2O3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	without	without	ADP	IN	_	_	_	_	_
25	dithiothreitol	dithiothreitol	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	DTT	DTT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	buthionine	buthionine	NUM	CD	NumType=Card	_	_	_	_
31	sulfoximine	sulfoximine	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	BSO	BSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	glutathione	glutathione	ADJ	JJ	Degree=Pos	_	_	_	_
40	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1915
# text = Apoptosis was assessed by cell morphology, flow cytometry, annexin V protein level, and terminal deoxynucleotidyl transferase labeling of DNA fragments.
1	Apoptosis	Apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
9	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	annexin	annexin	ADP	IN	_	_	_	_	_
12	V	V	PROPN	NNP	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	deoxynucleotidyl	deoxynucleotidyl	NOUN	NN	Number=Sing	_	_	_	_
19	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
20	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1916
# text = Cellular proliferation was determined by 5-bromo-2'-deoxyuridine incorporation into DNA and flow cytometry and by use of a mitotic arrest assay.
1	Cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
2	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bromo	bromo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
12	deoxyuridine	deoxyuridine	NOUN	NN	Number=Sing	_	_	_	_
13	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
14	into	into	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	flow	flow	VERB	VB	VerbForm=Inf	_	_	_	_
18	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	use	use	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	mitotic	mitotic	ADJ	JJ	Degree=Pos	_	_	_	_
25	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1917
# text = Mitochondrial transmembrane potential (delta psi(m)) was measured by means of rhodamine 123 staining and flow cytometry.
1	Mitochondrial	Mitochondrial	ADJ	JJ	Degree=Pos	_	_	_	_
2	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
3	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
6	psi	psi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	m	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	means	means	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	rhodamine	rhodamine	NOUN	NN	Number=Sing	_	_	_	_
17	123	123	NUM	CD	NumType=Card	_	_	_	_
18	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	flow	flow	VERB	VB	VerbForm=Inf	_	_	_	_
21	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1918
# text = Protein expression was assessed by western blot analysis or immunofluorescence.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	western	western	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1919
# text = RESULTS: Therapeutic concentrations of As2O3 (1-2 microM) had dual effects on malignant lymphocytes:
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Therapeutic	Therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
4	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	As2O3	As2O3	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1920
# text = 1) inhibition of growth through adenosine triphosphate (ATP) depletion and prolongation of cell cycle time and 2) induction of apoptosis.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
8	triphosphate	triphosphate	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	ATP	ATP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	prolongation	prolongation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
18	time	time	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	2	2	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	apoptosis.	apoptosis.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1921
# text = As2O3-induced apoptosis was preceded by delta psi(m) collapse.
1	As2O3	As2O3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
9	psi	psi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	m	m	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	collapse	collapse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1922
# text = DTT antagonized and BSO enhanced As2O3-induced ATP depletion, delta psi(m) collapse, and apoptosis.
1	DTT	DTT	PROPN	NNP	Number=Sing	_	_	_	_
2	antagonized	antagonize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	BSO	BSO	PROPN	NNP	Number=Sing	_	_	_	_
5	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	As2O3	As2O3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	ATP	Atp	NOUN	NN	Number=Sing	_	_	_	_
10	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
13	psi	psi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	m	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	collapse	collapse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1923
# text = Caspase-3 activation, usually resulting from delta psi(m) collapse, was not always associated with As2O3-induced apoptosis.
1	Caspase	Caspase	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	usually	usually	ADV	RB	_	_	_	_	_
7	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
10	psi	psi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	m	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	collapse	collapse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	always	always	ADV	RB	_	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	As2O3	As2O3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1924
# text = As2O3 induced PML (promyelocytic leukemia) protein degradation but did not modulate expression of cell cycle-related proteins, including c-myc, retinoblastoma protein, cyclin-dependent kinase 4, cyclin D1, and p53, or expression of differentiation-related antigens.
1	As2O3	As2O3	X	LS	_	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PML	pMl	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	myc	myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
36	D1	d1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
47	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1925
# text = CONCLUSIONS: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 microM As2O3.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
4	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
8	without	without	ADP	IN	_	_	_	_	_
9	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADV	RB	_	_	_	_	_
15	most	most	ADV	RBS	_	_	_	_	_
16	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
25	As2	As2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	O3	O3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1926
# text = As2O3 may prove useful in the treatment of malignant lymphoproliferative disorders.
1	As	as	ADP	IN	_	_	_	_	SpaceAfter=No
2	2O3	2O3	NUM	CD	NumType=Card	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
5	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphoproliferative	lymphoproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1927
# text = Document 00300389 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300389	00300389	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1928
# text = The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Legionella	Legionella	PROPN	NNP	Number=Sing	_	_	_	_
3	pneumophila	pneumophila	NOUN	NN	Number=Sing	_	_	_	_
4	rpoS	rpos	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	Acanthamoeba	Acanthamoeba	PROPN	NNP	Number=Sing	_	_	_	_
12	castellanii	castellanii	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1929
# text = To investigate regulatory networks in Legionella pneumophila, the gene encoding the homolog of the Escherichia coli stress and stationary-phase sigma factor RpoS was identified by complementation of an E. coli rpoS mutation.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	networks	network	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Legionella	Legionella	PROPN	NNP	Number=Sing	_	_	_	_
7	pneumophila	pneumophila	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
17	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
18	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	stationary	stationary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
23	sigma	sigma	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	RpoS	Rpos	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_
33	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
34	rpoS	rpos	NOUN	NN	Number=Sing	_	_	_	_
35	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1930
# text = An open reading frame that is approximately 60% identical to the E.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
3	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
4	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	approximately	approximately	ADV	RB	_	_	_	_	_
8	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	%	%	SYM	NN	Number=Sing	_	_	_	_
10	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1931
# text = coli rpoS gene was identified.
1	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
2	rpoS	rpos	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1932
# text = Western blot analysis showed that the level of L.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1933
# text = pneumophila
1	pneumophila	pneumophila	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1934
# text = RpoS increased in stationary phase.
1	RpoS	Rpo	NOUN	NNS	Number=Plur	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	stationary	stationary	ADJ	JJ	Degree=Pos	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1935
# text = An insertion mutation was constructed in the rpoS gene on the chromosome of L. pneumophila, and the ability of this mutant strain to survive various stress conditions was assayed and compared with results for the wild-type strain.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
3	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	rpoS	rpoS	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
15	pneumophila	pneumophila	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
23	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	_
26	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
27	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
28	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	type	type	NOUN	NN	Number=Sing	_	_	_	_
40	strain	strain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1936
# text = Both the mutant and wild-type strains were more resistant to stress when in stationary phase than when in the logarithmic phase of growth.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	strains	strains	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	stress	stress	VERB	VB	VerbForm=Inf	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	stationary	stationary	ADJ	JJ	Degree=Pos	_	_	_	_
17	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
18	than	than	SCONJ	IN	_	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	logarithmic	logarithmic	ADJ	JJ	Degree=Pos	_	_	_	_
23	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1937
# text = This finding indicates that L. pneumophila
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
6	pneumophila	pneumophila	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1938
# text = RpoS is not required for a stationary-phase-dependent resistance to stress.
1	RpoS	RpoS	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	stationary	stationary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1939
# text = Although the mutant strain was able to kill HL-60- and THP-1-derived macrophages, it could not replicate within a protozoan host, Acanthamoeba castellanii.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
4	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	kill	kill	VERB	VB	VerbForm=Inf	_	_	_	_
9	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	protozoan	protozoan	NOUN	NN	Number=Sing	_	_	_	_
28	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	Acanthamoeba	Acanthamoeba	PROPN	NNP	Number=Sing	_	_	_	_
31	castellanii	castellanii	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1940
# text = These data suggest that L.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1941
# text = pneumophila possesses a growth phase-dependent resistance to stress that is independent of RpoS control and that RpoS likely regulates genes that enable it to survive in the environment within protozoa.
1	pneumophila	pneumophila	NOUN	NN	Number=Sing	_	_	_	_
2	possesses	possess	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	stress	stress	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	RpoS	Rpos	ADJ	JJ	Degree=Pos	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	RpoS	RpoS	PROPN	NNP	Number=Sing	_	_	_	_
20	likely	likely	ADV	RB	_	_	_	_	_
21	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	enable	enable	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	environment	environment	NOUN	NN	Number=Sing	_	_	_	_
31	within	within	ADP	IN	_	_	_	_	_
32	protozoa	protozoa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1942
# text = Our data indicate that the role of rpoS in L. pneumophila is very different from what has previously been reported for E. coli rpoS.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	rpoS	rpo	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
11	pneumophila	pneumophila	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	very	very	ADV	RB	_	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	from	from	SCONJ	IN	_	_	_	_	_
16	what	what	PRON	WP	PronType=Int	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	previously	previously	ADV	RB	_	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_
23	coli	coli	PROPN	NNPS	Number=Plur	_	_	_	_
24	rpoS.	rpoS.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1943
# text = Document 00300390 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300390	00300390	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1944
# text = Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
13	senescence	senescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1945
# text = The costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
9	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	some	some	DET	DT	_	_	_	_	_
18	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1946
# text = Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transiently	transiently	ADV	RB	_	_	_	_	_
11	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	T	t	NUM	CD	NumType=Card	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	declines	decline	NOUN	NNS	Number=Plur	_	_	_	_
20	progressively	progressively	ADV	RB	_	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
24	senescence	senescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1947
# text = In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
11	frequently	frequently	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	+	+	SYM	SYM	_	_	_	_	_
15	T	t	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	completely	completely	ADV	RB	_	_	_	_	_
19	lose	lose	VERB	VB	VerbForm=Inf	_	_	_	_
20	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	during	during	ADP	IN	_	_	_	_	_
24	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
25	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	with	with	SCONJ	IN	_	_	_	_	_
28	aging	ag	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1948
# text = This correlates with changes of nuclear protein-binding activities to two motifs, site alpha and beta, within the CD28 minimal promoter.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
22	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1949
# text = Both alpha- and beta-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells.
1	Both	both	DET	DT	_	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
8	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	CD28	CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	+	+	SYM	SYM	_	_	_	_	_
19	T	t	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	some	some	DET	DT	_	_	_	_	_
25	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1950
# text = These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site beta- but not site alpha-binding activities.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	coordinately	coordinately	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	except	except	ADP	IN	_	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
9	senescence	senescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1951
# text = In contrast, T cell activation induces a parallel decline in both site alpha- and beta-binding activities.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	t	NUM	CD	NumType=Card	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
10	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1952
# text = CD4+ and CD8+
1	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	+	+	SYM	SYM	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 1953
# text = T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	pronounced	pronounced	ADJ	JJ	Degree=Pos	_	_	_	_
17	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	senescent	senescent	ADJ	JJ	Degree=Pos	_	_	_	_
24	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	T	t	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1954
# text = In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta- bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADP	IN	_	_	_	_	_
3	expanded	expand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	CD4+CD28null	CD4+CD28null	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	CD8+CD28null	CD8+CD28null	PROPN	NNP	Number=Sing	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	uniformly	uniformly	ADJ	JJ	Degree=Pos	_	_	_	_
10	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	resembling	resembl	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
22	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	chronically	chronically	ADV	RB	_	_	_	_	_
25	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	senescent	senescent	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1955
# text = Document 00300393 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300393	00300393	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1956
# text = The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
9	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	HSF1	HSF1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	avian	avian	ADJ	JJ	Degree=Pos	_	_	_	_
21	erythroblast	erythroblast	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	HD6	Hd6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1957
# text = Avian cells express three heat shock transcription factor (HSF) genes corresponding to a novel factor, HSF3, and homologs of mouse and human HSF1 and HSF2.
1	Avian	avian	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
6	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HSF	HSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	HSF3	HSF3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	homologs	homolog	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	HSF1	Hsf1	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1958
# text = Analysis of the biochemical and cell biological properties of these HSFs reveals that HSF3 has properties in common with both HSF1 and HSF2 and yet has features which are distinct from both.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
7	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
8	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	HSFs	HSF	ADJ	JJ	Degree=Pos	_	_	_	_
12	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	HSF3	HSF3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	HSF1	HSF1	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	HSF2	HSF2	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	yet	yet	CCONJ	CC	_	_	_	_	_
26	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	both	both	DET	DT	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1959
# text = HSF3 is constitutively expressed in the erythroblast cell line HD6, the lymphoblast cell line MSB, and embryo fibroblasts, and yet its DNA-binding activity is induced only upon exposure of HD6 cells to heat shock.
1	HSF3	HSF3	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	constitutively	constitutively	ADV	RB	_	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroblast	erythroblast	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	HD6	HD6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	lymphoblast	lymphoblast	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	MSB	Msb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	embryo	embryo	NOUN	NN	Number=Sing	_	_	_	_
20	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	yet	yet	ADV	RB	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	upon	upon	ADP	IN	_	_	_	_	_
33	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	HD6	HD6	NUM	CD	NumType=Card	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
39	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1960
# text = Acquisition of HSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a DNA-binding trimer, whereas the effect of heat shock on HSF1 is oligomerization of an inert monomer to a DNA-binding trimer.
1	Acquisition	Acquisition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	HD6	HD6	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	non-DNA	non-DNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	whereas	whereas	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
33	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	inert	inert	ADJ	JJ	Degree=Pos	_	_	_	_
41	monomer	monomer	NOUN	NN	Number=Sing	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1961
# text = Induction of HSF3 DNA-binding activity is delayed compared with that of HSF1.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1962
# text = As occurs for HSF1, heat shock leads to the translocation of HSF3 to the nucleus.
1	As	as	SCONJ	IN	_	_	_	_	_
2	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
7	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
8	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1963
# text = HSF exhibits the properties of a transcriptional activator, as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4-HSF3 protein on a GAL4 reporter construct.
1	HSF	HSF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	exhibits	exhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transiently	transiently	ADV	RB	_	_	_	_	_
18	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	_
20	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
25	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	independently	independently	ADV	RB	_	_	_	_	_
34	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
41	GAL4	Gal4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	HSF3	HSF3	NOUN	NN	Number=Sing	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	GAL4	GAL4	PROPN	NNP	Number=Sing	_	_	_	_
48	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
49	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1964
# text = These results reveal that HSF3 is negatively regulated in avian cells and acquires DNA-binding activity in certain cells upon heat shock.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HSF3	HSF3	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	negatively	negatively	ADV	RB	_	_	_	_	_
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	avian	avian	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	acquires	acquire	NOUN	NNS	Number=Plur	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	upon	upon	ADP	IN	_	_	_	_	_
22	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
23	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1965
# text = Document 00300399 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300399	00300399	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1966
# text = Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	airway	airway	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
12	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1967
# text = Glucocorticoid (GC)-insensitive asthma is a challenging clinical problem that can be associated with life-threatening disease progression.
1	Glucocorticoid	Glucocorticoid	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
7	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	challenging	challenging	ADJ	JJ	Degree=Pos	_	_	_	_
11	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
12	problem	problem	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	life	life	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	threatening	threaten	VERB	VBG	VerbForm=Ger	_	_	_	_
21	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
22	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1968
# text = The molecular basis of GC insensitivity is unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GC	GC	NOUN	NN	Number=Sing	_	_	_	_
6	insensitivity	insensitivity	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1969
# text = Alternative splicing of the GC receptor (GCR) pre-mRNA generates a second GCR, termed GCRbeta, which does not bind GC but antagonizes the transactivating activity of the classic GCR.
1	Alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
2	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	pre-mRNA	pre-mRNa	PROPN	NNP	Number=Sing	_	_	_	_
11	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	GCR	Gcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
23	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	antagonizes	antagonize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	classic	classic	ADJ	JJ	Degree=Pos	_	_	_	_
32	GCR	Gcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1970
# text = Thus increased expression of GCRbeta could account for glucocorticoid insensitivity.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	insensitivity	insensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1971
# text = Bronchoalveolar lavage (BAL) cells and peripheral blood mononuclear cells (PBMC) were examined for GCRbeta immunoreactivity using a GCRbeta-specific antibody by immunohistochemical staining.
1	Bronchoalveolar	Bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
2	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	BAL	Bal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
19	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	immunohistochemical	immunohistochemical	ADJ	JJ	Degree=Pos	_	_	_	_
28	staining	staining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1972
# text = Cell localization of GCRbeta expression was performed using a double immunostaining technique.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	double	double	NOUN	NN	Number=Sing	_	_	_	_
11	immunostaining	immunostain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	technique	technique	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1973
# text = Patients with GC-insensitive asthma expressed a significantly higher number of GCRbeta-immunoreactive cells in their BAL and peripheral blood than GC-sensitive asthmatics or normal control subjects.
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
7	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	significantly	significantly	ADV	RB	_	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	number	number	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	BAL	Bal	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
27	asthmatics	asthmatic	NOUN	NNS	Number=Plur	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1974
# text = Furthermore, GCRbeta expression in GC-insensitive asthma was particularly high in airway T cells, which are thought to play a major role in the pathogenesis of asthma.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
9	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	particularly	particularly	ADV	RB	_	_	_	_	_
12	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	airway	airway	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1975
# text = We also examined the expression of GCRbeta in specimens from the airways of patients with chronic bronchitis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	specimens	specimen	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	airways	airway	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
17	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1976
# text = In chronic bronchitis, few cells were GCRbeta-positive and their numbers did not differ significantly from normal control subjects.
1	In	in	ADP	IN	_	_	_	_	_
2	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
3	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1977
# text = We conclude that GC-insensitive asthma is associated with increased expression of GCRbeta in airway T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
7	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	airway	airway	PROPN	NNP	Number=Sing	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1978
# text = Document 003003106 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003106	003003106	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1979
# text = Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells.
1	Tyrphostin	Tyrphostin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	AG	AG	ADV	RB	_	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	490	490	NUM	CD	NumType=Card	_	_	_	_
5	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	JAK3/STAT5	JAK3/STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	b	benefit	NOUN	NN	Number=Sing	_	_	_	_
13	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1980
# text = Janus kinase 3 (JAK3) is a cytoplasmic tyrosine kinase required for T cell development and activated by cytokines that utilize the interleukin-2 (IL-2) receptor common gamma chain (gamma(c)).
1	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	development	development	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	utilize	utilize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
33	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
34	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
35	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1981
# text = Genetic inactivation of JAK3 is manifested as severe combined immunodeficiency disease (SCID) in humans and mice.
1	Genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
2	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
9	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
11	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	SCID	SCID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1982
# text = These findings have suggested that JAK3 represents a pharmacological target to control certain lymphoid-derived diseases.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	_
7	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
10	target	target	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
13	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1983
# text = Here we provide novel evidence that AG-490 potently inhibits the autokinase activity of JAK3 and tyrosine phosphorylation and DNA binding of signal transducer and activator of transcription 5a and 5b (STAT5a/b).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	AG	AG	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	490	490	NUM	CD	NumType=Card	_	_	_	_
10	potently	potently	ADV	RB	_	_	_	_	_
11	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	autokinase	autokinase	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
25	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	b	b	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1984
# text = Similar inhibitory effects were observed with other cytokines that use gamma(c).
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1985
# text = AG-490 also inhibited IL-2-mediated proliferative growth in human T cells with an IC50) = 25 microM that was partially recoverable.
1	AG	ag	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	490	490	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	IC50	IC50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	=	=	SYM	SYM	_	_	_	_	_
22	25	25	NUM	CD	NumType=Card	_	_	_	_
23	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	partially	partially	ADV	RB	_	_	_	_	_
27	recoverable	recoverable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1986
# text = Moreover, we demonstrate that this inhibitor prevented tetanus toxoid antigen-specific T cell proliferation and expansion but failed to block activation of Zap70 or p56Lck after anti-CD3 stimulation of human T cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
8	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	tetanus	tetanus	ADP	IN	_	_	_	_	_
10	toxoid	toxoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	antigen-specific	antigen-specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Zap70	Zap70	PROPN	NNP	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	p56Lck	p56Lck	PROPN	NNP	Number=Sing	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1987
# text = Taken together, these findings suggest that AG-490 inhibits the JAK3-mediated Type II signaling pathway but not the T cell receptor-derived Type I pathway and possesses therapeutic potential for T cell-derived pathologies such as graft-versus-host disease, allergy, and autoimmune disorders.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	AG	AG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	490	490	NUM	CD	NumType=Card	_	_	_	_
11	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	Type	type	NOUN	NN	Number=Sing	_	_	_	_
17	II	ii	NUM	CD	NumType=Card	_	_	_	_
18	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	T	T	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	derived	derived	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	Type	type	NOUN	NN	Number=Sing	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	possesses	possess	NOUN	NNS	Number=Plur	_	_	_	_
33	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
34	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	pathologies	pathology	NOUN	NNS	Number=Plur	_	_	_	_
41	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	graft	graft	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	versus	versus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	host	host	NOUN	NN	Number=Sing	_	_	_	_
48	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	allergy	allergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
54	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1988
# text = Document 003003107 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003107	003003107	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1989
# text = Inhibition of T cell activation by the extracellular matrix protein tenascin.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	tenascin	tenascin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1990
# text = Tenascin (TN) is an extracellular matrix protein that is expressed widely in the fetus and sparingly in the adult, but reappears at high levels in certain areas of tissue insult such as tumor matrices and sites of wound healing.
1	Tenascin	Tenascin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TN	TN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	widely	widely	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	fetus	fetus	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	sparingly	sparingly	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	adult	adult	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	reappears	reappear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
30	areas	area	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
33	insult	insult	NOUN	NN	Number=Sing	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	matrices	matrice	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	wound	wound	ADJ	JJ	Degree=Pos	_	_	_	_
42	healing	healing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1991
# text = We show here that soluble TN inhibits proliferation of human T cells in response to alpha CD3
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	TN	Tn	NOUN	NN	Number=Sing	_	_	_	_
7	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
8	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1992
# text = Ab co-immobilized with the extracellular matrix protein fibronectin (FN).
1	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	_
2	co-immobilized	co-immobilize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FN	FN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1993
# text = TN also inhibits proliferation driven by alpha CD3/IL-2 or by phorbol ester/IL-2, and it prevents high level induction of IL-2R.
1	TN	rn	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
5	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	CD3/IL	Cd3/il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
14	ester/IL	ester/il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1994
# text = The presence of TN in culture medium does not detectably alter the pattern of tyrosine phosphorylation resulting from T cell triggering with alpha CD3, but at later time points prevents the appearance of functional NF-AT1 transcription factor complexes in T cell nuclear extracts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TN	rn	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
7	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	detectably	detectably	ADV	RB	_	_	_	_	_
11	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
21	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
29	time	time	NOUN	NN	Number=Sing	_	_	_	_
30	points	point	NOUN	NNS	Number=Plur	_	_	_	_
31	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	AT1	AT1	PROPN	NNP	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
45	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
46	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1995
# text = These findings are consistent with the postulated role for TN as a natural antagonist to FN action, and suggest that T cell responses occurring at tissue sites in which TN is expressed could be influenced by its presence.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	TN	TN	PROPN	NNP	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	FN	Fn	VERB	VB	VerbForm=Inf	_	_	_	_
17	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
25	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	TN	TN	PROPN	NNP	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1996
# text = Document 003003108 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003108	003003108	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1997
# text = CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation.
1	CBP	CBp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
3	p300	p300	NUM	CD	NumType=Card	_	_	_	_
4	integrates	integrate	NOUN	NNS	Number=Plur	_	_	_	_
5	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1998
# text = NF-ATc, an inducibly expressed transcription factor, controls gene expression in T lymphocytes and cardiomyocytes.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	inducibly	inducibly	ADV	RB	_	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cardiomyocytes	cardiomyocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1999
# text = We show here that the transcriptional co-activators CBP/p300 bind to and control the activity of the inducible N-terminal transactivation domain of NF-ATc, TAD-A.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	co-activators	co-activator	NOUN	NNS	Number=Plur	_	_	_	_
8	CBP	Cbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	p300	p300	NUM	CD	NumType=Card	_	_	_	_
11	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	TAD	TAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2000
# text = Similar to the N terminal transactivation domain of c-Jun, TAD-A is inducibly phosphorylated, but this phosphorylation is dispensable for the interaction with CBP/p300.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	N	N	PROPN	NNP	Number=Sing	_	_	_	_
5	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	TAD	TAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	A	a	PROPN	NNP	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	inducibly	inducibly	ADV	RB	_	_	_	_	_
18	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	p300	p300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2001
# text = Constitutive active versions of c-Raf and Rac synergistically enhance the CBP/p300-mediated increase of TAD-A activity, indicating the important role CBP/p300 plays in the integration of T cell activation signals.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	versions	version	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	_
10	synergistically	synergistically	ADV	RB	_	_	_	_	_
11	enhance	enhance	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CBP	CBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	p300	p300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	TAD	TAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	CBP	Cbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	p300	p300	NUM	CD	NumType=Card	_	_	_	_
32	plays	play	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2002
# text = Since a mutation of CBP abolishing HAT activity is almost as active as wild-type CBP in T cells, functions of CBP/p300 other than histone acetylation appear to control the NF-AT-dependent transcription in T cells.
1	Since	since	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	_
6	abolishing	abolish	VERB	VBG	VerbForm=Ger	_	_	_	_
7	HAT	hat	DET	WDT	PronType=Int	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	almost	almost	ADV	RB	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	CBP	Cbp	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	p300	p300	NUM	CD	NumType=Card	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	histone	histone	PRON	NN	Number=Sing	_	_	_	_
30	acetylation	acetylation	NOUN	NN	Number=Sing|Typo=Yes	_	_	_	_
31	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	AT	AT	ADV	RB	_	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2003
# text = Document 003003114 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003114	003003114	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2004
# text = Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.
1	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	shares	share	NOUN	NNS	Number=Plur	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interacts	interacts	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
26	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	promoting	promoting	VERB	VBG	VerbForm=Ger	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2005
# text = The survival-promoting activity of the Bcl-2 family of proteins appears to be modulated by interactions between various cellular proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
20	between	between	ADP	IN	_	_	_	_	_
21	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2006
# text = We have identified a novel cellular protein, Bik, that interacts with the cellular survival-promoting proteins, Bcl-2 and Bcl-xL, as well as the viral survival-promoting proteins, Epstein Barr virus-BHRF1 and adenovirus E1B-19 kDa.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	promoting	promoting	VERB	VBG	VerbForm=Ger	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	xL	xl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	ADV	RB	_	_	_	_	_
30	well	well	ADV	RB	Degree=Pos	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
34	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	promoting	promoting	VERB	VBG	VerbForm=Ger	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	_
40	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
41	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	BHRF1	Bhrf1	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
46	E1B	E1b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	19	19	NUM	CD	NumType=Card	_	_	_	_
49	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2007
# text = In transient transfection assays, Bik promotes cell death in a manner similar to the death-promoting members of the Bcl-2 family, Bax and Bak.
1	In	in	ADP	IN	_	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	_
7	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	death	death	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
13	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Bax	Bax	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Bak	Bak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2008
# text = This death-promoting activity of Bik can be suppressed by coexpression of Bcl-2, Bcl-XL, EBV-BHRF1 and E1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-XL	-XL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	E1B	E1B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	19	19	NUM	CD	NumType=Card	_	_	_	_
27	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
29	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
36	target	target	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	both	both	CCONJ	CC	_	_	_	_	_
39	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
42	anti-apoptotic	anti-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
43	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2009
# text = While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family, it does share a 9 amino acid domain (BH3) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins.
1	While	while	SCONJ	IN	_	_	_	_	_
2	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	_
3	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
6	overt	over	ADP	IN	Typo=Yes	_	_	_	_
7	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	BH1	Bh1	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	BH2	Bh2	NOUN	NN	Number=Sing	_	_	_	_
13	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
15	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	share	share	VERB	VB	VerbForm=Inf	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	9	9	NUM	CD	NumType=Card	_	_	_	_
28	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
29	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
30	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	BH3	BH3	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	Bax	Bax	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	Bak	Bak	PROPN	NNP	Number=Sing	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
43	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
49	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
52	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2010
# text = Document 003003117 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003117	003003117	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2011
# text = Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD20/B1	CD20/B1	PROPN	NNP	Number=Sing	_	_	_	_
12	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
13	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	diverged	diverge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
23	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2012
# text = The CD20(B1) gene encodes a B cell-specific protein involved in the regulation of human B cell proliferation and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD20	CD20	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	B1	B1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2013
# text = Studies with 5' deletion CD20 promoter-CAT constructs have previously revealed two regions of the promoter between bases -186 and -280 and between bases -280 and -454 which contained positive regulatory elements.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	's	PUNCT	``	_	_	_	_	_
5	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
6	CD20	CD20	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
10	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	previously	previously	ADV	RB	_	_	_	_	_
13	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	bases	bas	NOUN	NNS	Number=Plur	_	_	_	_
21	-186	-186	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	280	280	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	bases	bas	NOUN	NNS	Number=Plur	_	_	_	_
28	-280	-280	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	454	454	NUM	CD	NumType=Card	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2014
# text = In this study we identified a sequence element present in the most proximal region located between bases -214 and -201, TTCTTCTAATTAA, which is important in the high constitutive expression of CD20 in mature B cells and the induction of CD20 in pre-B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	most	most	ADV	RBS	_	_	_	_	_
13	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	bases	bas	NOUN	NNS	Number=Plur	_	_	_	_
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	214	214	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	201	201	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	TTCTTCTAATTAA	TTCTTCTAATTAa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
32	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
47	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2015
# text = This sequence element was referred to as the BAT box and its deletion significantly reduced the activity of a CD20 promoter-CAT construct in B cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
10	box	box	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
14	significantly	significantly	ADV	RB	_	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
24	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2016
# text = Mobility shift assays with various mutant probes and B cell nuclear extracts demonstrated that the core sequence TAAT was essential for binding to this site.
1	Mobility	Mobility	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
7	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	core	core	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	TAAT	Taat	PRON	WDT	PronType=Rel	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	SCONJ	IN	_	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2017
# text = Cross competition experiments with an octamer sequence from the Ig heavy chain promoter, the BAT box, and a TA-rich sequence present in the CD21 promoter revealed that all three sequences bound the same nuclear proteins suggesting that the BAT box binding proteins were Oct-1 and Oct-2. Southwestern blotting and UV cross-linking studies confirmed that the BAT box binding proteins were Oct-1 and Oct-2.
1	Cross	cross	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
11	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
12	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
17	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	TA	Ta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	CD21	Cd21	PROPN	NNP	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	all	all	DET	DT	_	_	_	_	_
33	three	three	NUM	CD	NumType=Card	_	_	_	_
34	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
35	bound	bound	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
40	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
44	box	box	NOUN	NN	Number=Sing	_	_	_	_
45	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
46	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
47	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-1	-1	NUM	CD	NumType=Card	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_
54	Southwestern	southwestern	ADJ	JJ	Degree=Pos	_	_	_	_
55	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
58	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	linking	link	NOUN	NN	Number=Sing	_	_	_	_
61	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
62	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
63	that	that	SCONJ	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
66	box	box	NOUN	NN	Number=Sing	_	_	_	_
67	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
68	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
69	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
70	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	-1	-1	NUM	CD	NumType=Card	_	_	_	_
72	and	and	CCONJ	CC	_	_	_	_	_
73	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
74	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
75	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2018
# text = The affinity of the BAT box binding proteins for the BAT box was approximately 25-fold less than for the octamer sequence and the BAT box binding proteins dissociated from the BAT box 10-fold more rapidly than from the octamer sequence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
6	box	box	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
12	box	box	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
18	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
27	box	box	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	dissociated	dissociate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	BAT	bat	PROPN	NNP	Number=Sing	_	_	_	_
34	box	box	NOUN	NN	Number=Sing	_	_	_	_
35	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
38	more	more	ADV	RBR	_	_	_	_	_
39	rapidly	rapidly	ADV	RB	_	_	_	_	_
40	than	than	ADP	IN	_	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
44	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2019
# text = Despite this lower affinity, a trimer of the BAT box sequence was as efficiently transactivated by an Oct-2 expression vector as was a trimer of the octamer sequence in HeLa cells.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
4	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	BAT	bat	PROPN	NNP	Number=Sing	_	_	_	_
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	efficiently	efficiently	ADV	RB	_	_	_	_	_
16	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
31	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2020
# text = The BAT box and Oct-2 were also implicated in the induction of CD20 in the pre-B cell line, PB-697, via phorbol esters.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
3	box	box	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD20	CD20	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
19	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	PB	Pb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	697	697	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	via	via	ADP	IN	_	_	_	_	_
28	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
29	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2021
# text = The induction of CD20 mRNA was temporally associated with induction of Oct-2 mRNA and a BAT box-deleted CD20-CAT construct, in contrast to the wild type, was poorly induced by phorbol esters.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	temporally	temporally	ADV	RB	_	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
19	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
25	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	wild	wild	NOUN	NN	Number=Sing	_	_	_	_
32	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	poorly	poorly	ADV	RB	_	_	_	_	_
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
39	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2022
# text = Together these results suggest that the BAT box binding proteins are important in the B cell specific expression of CD20 and perhaps CD21.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	perhaps	perhaps	ADV	RB	_	_	_	_	_
23	CD21	Cd21	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2023
# text = Document 003003118 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003118	003003118	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2024
# text = Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-alpha.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
8	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2025
# text = CD38 is a leukocyte differentiation antigen that has been thought to be a phenotypic marker of different subpopulations of T- and B- lymphocytes.
1	CD38	Cd38	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
15	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	subpopulations	subpopulation	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2026
# text = In myeloid cells, CD38 is expressed during early stages of differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2027
# text = Virtually no information is available on regulation and functions of CD38.
1	Virtually	virtually	ADV	RB	_	_	_	_	_
2	no	no	DET	DT	_	_	_	_	_
3	information	information	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	38	38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2028
# text = Recently we reported that all-trans-retinoic acid (ATRA) is a potent and highly specific inducer of CD38 expression in human promyelocytic leukemia cells.
1	Recently	recently	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	all	all	DET	DT	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	highly	highly	ADV	RB	_	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD38	CD38	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2029
# text = Here we report that ATRA-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid-alpha receptor (RAR alpha).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
11	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
19	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2030
# text = ATRA failed to induce CD38 expression in a mutant subclone of the HL-60 myeloid leukemia cell line (designated HL-60R) that is relatively resistant to ATRA-induced granulocytic differentiation.
1	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
2	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
5	CD38	Cd38	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
10	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	60	60	NUM	CD	NumType=Card	_	_	_	_
16	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	60R	60R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	relatively	relatively	ADV	RB	_	_	_	_	_
29	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2031
# text = Retroviral vector-mediated transduction of RA receptor (RAR alpha) into this HL-60R subclone completely restored the sensitivity of these cells to ATRA in terms of their ability to express CD38.
1	Retroviral	Retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
2	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	60R	60r	NOUN	NN	Number=Sing	_	_	_	_
18	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
19	completely	completely	ADV	RB	_	_	_	_	_
20	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
35	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2032
# text = In contrast, CD38 expression was not inducible by ATRA in HL-60R cells, transfected with a functional RAR beta, RAR gamma, or RXR alpha receptor.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD38	CD38	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	60R	60r	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
22	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2033
# text = Induction of CD38 in acute promyelocytic and acute myeloblastic leukemia cells was independent of ATRA-induced cytodifferentiation.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
6	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloblastic	myeloblastic	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cytodifferentiation	cytodifferentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2034
# text = Following culture with ATRA, increased CD38 protein levels were also observed in normal CD34+ bone marrow cells, but not on normal circulating granulocytes.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	CD38	CD38	NUM	CD	NumType=Card	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	bone	bone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	ADV	RB	_	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	circulating	circulating	NOUN	NN	Number=Sing	_	_	_	_
26	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2035
# text = From these results, we conclude that CD38 is ATRA inducible in myeloid leukemia cells and normal CD34+ bone marrow cells.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	ATRA	ATRa	ADV	RB	_	_	_	_	_
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	CD34	Cd34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
21	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2036
# text = This effect is independent of differentiation and is mediated by RAR alpha in HL-60 cells, suggesting a similar role for RAR alpha in CD38 expression in other hematopoietic cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	60	60	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
25	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
31	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2037
# text = Document 003003119 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003119	003003119	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2038
# text = Altered memory T cell differentiation in patients with early rheumatoid arthritis.
1	Altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
3	T	t	NUM	CD	NumType=Card	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2039
# text = The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate inflammation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
3	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	without	without	ADP	IN	_	_	_	_	_
19	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
20	Th2	th2	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	modulate	modulate	ADJ	JJ	Degree=Pos	_	_	_	_
27	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2040
# text = To test whether disordered memory T cell differentiation contributes to the typical Th1-dominated chronic inflammation in RA we investigated differentiation of resting CD4+ memory T cells in patients with early (6 wk to 12 mo) untreated RA and in age- and sex-matched healthy controls in vitro.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	disordered	disorder	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
13	Th1	th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dominated	dominate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
17	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	SCONJ	IN	_	_	_	_	_
24	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	early	early	ADV	RB	Degree=Pos	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	wk	wk	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	12	12	NUM	CD	NumType=Card	_	_	_	_
39	mo	mo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
42	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	sex	sex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-matched	-match	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
50	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
51	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2041
# text = No difference in cytokine secretion profiles of freshly isolated memory T cells was detected between patients and controls.
1	No	no	DET	DT	_	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	freshly	freshly	ADV	RB	_	_	_	_	_
9	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2042
# text = A cell culture system was then employed that permitted the differentiation of Th effectors from resting memory T cells by short term priming.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	then	then	ADV	RB	PronType=Dem	_	_	_	_
7	employed	employ	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	permitted	permit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Th	th	PROPN	NNP	Number=Sing	_	_	_	_
14	effectors	effector	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	SCONJ	IN	_	_	_	_	_
16	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
22	term	term	NOUN	NN	Number=Sing	_	_	_	_
23	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2043
# text = Marked differences were found in response to priming.
1	Marked	marked	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	SCONJ	IN	_	_	_	_	_
8	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2044
# text = Th2 cells could be induced in all healthy controls by priming with anti-CD28 in the absence of TCR ligation.
1	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
9	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	priming	prim	VERB	VBG	VerbForm=Ger	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	anti-CD28	anti-cd28	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
19	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2045
# text = By contrast, priming under those conditions resulted in Th2 differentiation in only 9 of 24 RA patients.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
5	under	under	ADP	IN	_	_	_	_	_
6	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	9	9	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	24	24	NUM	CD	NumType=Card	_	_	_	_
17	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2046
# text = Exogenous IL-4 could overcome the apparent Th2 differentiation defect in seven patients but was without effect in the remaining eight patients.
1	Exogenous	Exogenous	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
9	Th2	Th2	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	seven	seven	NUM	CD	NumType=Card	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	without	without	ADP	IN	_	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	remaining	remaining	VERB	VBG	VerbForm=Ger	_	_	_	_
22	eight	eight	NUM	CD	NumType=Card	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2047
# text = In all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28.
1	In	in	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
17	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
36	after	after	SCONJ	IN	_	_	_	_	_
37	priming	prim	VERB	VBG	VerbForm=Ger	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	anti-CD28	anti-cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2048
# text = The data suggest that CD4+ memory T cells from patients with early untreated RA manifest an intrinsic abnormality in their ability to differentiate into specific cytokine-producing effector cells that might contribute to the characteristic Th1-dominated chronic (auto)immune inflammation in RA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
8	T	t	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
15	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
16	manifest	manifest	ADV	RBS	Degree=Sup	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
19	abnormality	abnormality	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
25	into	into	ADP	IN	_	_	_	_	_
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
30	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
34	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
38	Th1	th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
40	dominated	dominate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	chronic	chronic	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	auto	auto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
46	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2049
# text = Document 003003122 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003122	003003122	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2050
# text = c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors.
1	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
16	granules	granule	NOUN	NNS	Number=Plur	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	death	death	NOUN	NN	Number=Sing	_	_	_	_
19	effectors	effector	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2051
# text = The contact of natural killer (NK) cells with foreign cells and with certain virus-infected or tumor cells triggers the cytolytic machinery of NK cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
5	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	foreign	foreign	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2052
# text = This triggering leads to exocytosis of the cytotoxic NK cell granules.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
3	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	exocytosis	exocytosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
9	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2053
# text = The oncoproteins c-Myc and E1A render cells vulnerable to NK cell mediated cytolysis yet the mechanisms of sensitization are not well understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
3	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	render	render	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	vulnerable	vulnerable	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
14	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	cytolysis	cytolysis	NOUN	NN	Number=Sing	_	_	_	_
16	yet	yet	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	sensitization	sensitization	NOUN	NN	Number=Sing	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2054
# text = In a model where foreign cells (rat fibroblasts) were cocultured with human IL-2 activated NK cells, we observed that NK cells were capable of efficiently killing their targets only if the cells overexpressed the oncogene c-Myc or E1A.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	_
4	where	where	ADV	WRB	PronType=Rel	_	_	_	_
5	foreign	foreign	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
9	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	cocultured	coculture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
29	of	of	SCONJ	IN	_	_	_	_	_
30	efficiently	efficiently	ADV	RB	_	_	_	_	_
31	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	_
32	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
34	only	only	ADV	RB	_	_	_	_	_
35	if	if	SCONJ	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	overexpressed	overexpress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
41	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2055
# text = Both the parental and the oncogene expressing fibroblasts similarly triggered phosphoinositide hydrolysis in the bound NK cells, demonstrating that NK cells were cytolytically activated in contact with both resistant parental and oncogene expressing sensitive target fibroblasts.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	parental	parental	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
7	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
8	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
9	similarly	similarly	ADV	RB	_	_	_	_	_
10	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	phosphoinositide	phosphoinositide	NOUN	NN	Number=Sing	_	_	_	_
12	hydrolysis	hydrolysis	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
16	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	cytolytically	cytolytically	ADV	RB	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
31	parental	parental	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	oncogene	oncogene	ADV	RB	_	_	_	_	_
34	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
36	target	target	NOUN	NN	Number=Sing	_	_	_	_
37	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2056
# text = The cell death was independent of wild-type p53 and was not inhibited by an anti-apoptotic protein EIB19K.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	death	death	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	anti-apoptotic	anti-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	EIB	EIB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	19K	19K	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2057
# text = These results provided evidence that c-Myc and E1A activated the NK cell induced cytolysis at a post-triggering stage of NK cell-target cell interaction.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	A	A	PROPN	NNP	Number=Sing	_	_	_	_
11	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	cytolysis	cytolysis	NOUN	NN	Number=Sing	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	post	post	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-triggering	-trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
21	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	target	target	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2058
# text = In consistence, the c-Myc and E1A overexpressing fibroblasts were more sensitive to the cytolytic effects of isolated NK cell-derived granules than parental cells.
1	In	in	ADP	IN	_	_	_	_	_
2	consistence	consistence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	_
10	overexpressing	overexpresse	ADJ	JJ	Degree=Pos	_	_	_	_
11	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	more	more	ADV	RBR	_	_	_	_	_
14	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	granules	granule	NOUN	NNS	Number=Plur	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2059
# text = The data indicate that oncogenes activate the cytotoxicity of NK cell granules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
6	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2060
# text = This mechanism can have a role in directing the cytolytic action of NK cells towards the virus-infected and cancer cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	SCONJ	IN	_	_	_	_	_
8	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	action	action	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	towards	towards	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2061
# text = Document 003003125 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003125	003003125	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2062
# text = Lymphocyte glucocorticoid receptor: predictor of sertraline response in adolescent major depressive disorder (MDD).
1	Lymphocyte	Lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	predictor	predictor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	sertraline	sertraline	NOUN	NN	Number=Sing	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adolescent	adolescent	ADJ	JJ	Degree=Pos	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	depressive	depressive	ADJ	JJ	Degree=Pos	_	_	_	_
13	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	MDD	MDD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2063
# text = Major depressive disorder (MDD) in adolescents demonstrates resistance to tricyclic antidepressants and absence of hypercortisolemia.
1	Major	major	ADJ	JJ	Degree=Pos	_	_	_	_
2	depressive	depressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	MDD	MDD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	adolescents	adolescent	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	tricyclic	tricyclic	ADJ	JJ	Degree=Pos	_	_	_	_
13	antidepressants	antidepressant	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	hypercortisolemia	hypercortisolemion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2064
# text = The efficacy of serotonin reuptake inhibitors (SRIs) is uncertain, and response predictors are unavailable.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	serotonin	serotonin	ADJ	JJ	Degree=Pos	_	_	_	_
5	reuptake	reuptake	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	SRIs	SRIs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	uncertain	uncertain	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	predictors	predictor	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	unavailable	unavailable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2065
# text = Abnormal fast feedback and negative feedback of the hypothalamic-pituitary-adrenal axis implicates a dampened limbic-hippocampal glucocorticoid type II receptor (GCII).
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	_
3	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-pituitary-adrenal	-pituitary-adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
11	axis	axis	NOUN	NN	Number=Sing	_	_	_	_
12	implicates	implicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	dampened	dampen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	limbic	limbic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	hippocampal	hippocampal	ADJ	JJ	Degree=Pos	_	_	_	_
18	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GCII	GCII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2066
# text = We hypothesized that lymphocyte GCII is altered in adolescent MDD and could serve as a marker for response to SRIs.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	GCII	GCII	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	adolescent	adolescent	ADJ	JJ	Degree=Pos	_	_	_	_
10	MDD	mdd	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	SRIs	SRIs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2067
# text = In an open-label study, adolescents (n = 20) meeting DSM-III-R criteria for MDD showed baseline lymphocyte GCII sites per cell (sites/cell) values of 793 +/- 106 versus 2,563 +/- 499 (+/- SEM) for matched controls (n = 18) (t = 3.5; df = 36; p < .001).
1	In	in	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	open	open	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	label	label	NOUN	NN	Number=Sing	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	adolescents	adolescent	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	n	not	NOUN	NN	Number=Sing	_	_	_	_
11	=	=	SYM	SYM	_	_	_	_	_
12	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	meeting	meet	NOUN	NN	Number=Sing	_	_	_	_
15	DSM	DSM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	III	III	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	R	R	PROPN	NNP	Number=Sing	_	_	_	_
20	criteria	criteria	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	MDD	MDD	PROPN	NNP	Number=Sing	_	_	_	_
23	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	_
25	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
26	GCII	Gcii	NUM	CD	NumType=Card	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
28	per	per	ADP	IN	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	values	value	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	793	793	NUM	CD	NumType=Card	_	_	_	_
38	+/-	+/-	SYM	SYM	_	_	_	_	_
39	106	106	NUM	CD	NumType=Card	_	_	_	_
40	versus	versus	ADP	IN	_	_	_	_	_
41	2,563	2,563	NUM	CD	NumType=Card	_	_	_	_
42	+/-	+/-	SYM	SYM	_	_	_	_	_
43	499	499	NUM	CD	NumType=Card	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	+/-	+/-	SYM	NFP	_	_	_	_	_
46	SEM	SEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	for	for	ADP	IN	_	_	_	_	_
49	matched	match	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	n	not	NOUN	NN	Number=Sing	_	_	_	_
53	=	=	SYM	SYM	_	_	_	_	_
54	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	t	t	NOUN	NN	Number=Sing	_	_	_	_
58	=	=	SYM	SYM	_	_	_	_	_
59	3.5	3.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	;	;	PUNCT	,	_	_	_	_	_
61	df	df	NOUN	NN	Number=Sing	_	_	_	_
62	=	=	SYM	SYM	_	_	_	_	_
63	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	;	;	PUNCT	,	_	_	_	_	_
65	p	p	NOUN	NN	Number=Sing	_	_	_	_
66	<	<	PUNCT	-LRB-	_	_	_	_	_
67	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2068
# text = GCII was bimodally distributed, with SRI responders differing from nonresponders (t = 3.9; df = 14; p < .001).
1	GCII	GCII	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	bimodally	bimodally	ADV	RB	_	_	_	_	_
4	distributed	distribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	SRI	Sri	NOUN	NN	Number=Sing	_	_	_	_
8	responders	responder	NOUN	NNS	Number=Plur	_	_	_	_
9	differing	differ	VERB	VBG	VerbForm=Ger	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	nonresponders	nonresponder	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	t	t	NUM	CD	NumType=Card	_	_	_	_
14	=	=	SYM	SYM	_	_	_	_	_
15	3.9	3.9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	_
17	df	df	NOUN	NN	Number=Sing	_	_	_	_
18	=	=	SYM	SYM	_	_	_	_	_
19	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	p	p	NOUN	NN	Number=Sing	_	_	_	_
22	<	<	PUNCT	-LRB-	_	_	_	_	_
23	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2069
# text = GCII accurately classified 90 percent of sertraline responders and 80 percent of nonresponders.
1	GCII	GCII	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	accurately	accurately	ADV	RB	_	_	_	_	_
3	classified	classify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	90	90	NUM	CD	NumType=Card	_	_	_	_
5	percent	percent	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	sertraline	sertraline	NOUN	NN	Number=Sing	_	_	_	_
8	responders	responder	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	80	80	NUM	CD	NumType=Card	_	_	_	_
11	percent	percent	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	nonresponders	nonresponder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2070
# text = Only SRI responders showed GCII sites/cell upregulated after 6 weeks of treatment (t = 2.1, df = 10; p < .05).
1	Only	only	ADV	RB	_	_	_	_	_
2	SRI	Sri	PROPN	NNP	Number=Sing	_	_	_	_
3	responders	responder	NOUN	NNS	Number=Plur	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	GCII	Gcii	PROPN	NNP	Number=Sing	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	weeks	week	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	t	t	NOUN	NN	Number=Sing	_	_	_	_
17	=	=	SYM	SYM	_	_	_	_	_
18	2.1	2.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	df	df	PROPN	NNP	Number=Sing	_	_	_	_
21	=	=	SYM	SYM	_	_	_	_	_
22	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	p	p	NOUN	NN	Number=Sing	_	_	_	_
25	<	<	PUNCT	-LRB-	_	_	_	_	_
26	.05	.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2071
# text = Document 003003126 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003126	003003126	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2072
# text = Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	core	core	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	cores	core	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2073
# text = Core binding factor (CBF), also known as polyomavirus enhancer-binding protein 2 and SL3 enhancer factor 1, is a mammalian transcription factor that binds to an element termed the core within the enhancers of the murine leukemia virus family of retroviruses.
1	Core	core	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	polyomavirus	polyomavirus	NOUN	NN	Number=Sing	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	SL3	SL3	NUM	CD	NumType=Card	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	element	element	NOUN	NN	Number=Sing	_	_	_	_
33	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	core	core	NOUN	NN	Number=Sing	_	_	_	_
36	within	within	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
42	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
43	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
44	family	family	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2074
# text = The core elements of the SL3 virus are important genetic determinants of the ability of this virus to induce T-cell lymphomas and the transcriptional activity of the viral long terminal repeat in T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	core	core	NOUN	NN	Number=Sing	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
11	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
31	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
32	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2075
# text = CBF consists of two subunits, a DNA binding subunit, CBF alpha, and a second subunit, CBF beta, that stimulates the DNA binding activity of CBF alpha.
1	CBF	Cbf	PROPN	NNP	Number=Sing	_	_	_	_
2	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
24	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
31	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2076
# text = One of the genes that encodes a CBF alpha subunit is AML1, also called Cbf alpha
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	CBF	Cbf	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	AML1	AML1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	Cbf	Cbf	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2077
# text = 2.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2078
# text = This locus is rearranged by chromosomal translocations in human myeloproliferative disorders and leukemias.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	myeloproliferative	myeloproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
11	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2079
# text = An exogenously expressed Cbf alpha 2-encoded subunit (CBF alpha 2-451) stimulated transcription from the SL3 enhancer in P19 and HeLa cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	exogenously	exogenously	ADV	RB	_	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Cbf	Cbf	PROPN	NNP	Number=Sing	_	_	_	_
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	2-	2-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	451	451	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	P19	P19	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2080
# text = Activity was mediated through the core elements.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	through	through	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	core	core	NOUN	NN	Number=Sing	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2081
# text = Three different isoforms of CBF beta were also tested for transcriptional activity on the SL3 enhancer.
1	Three	Three	NUM	CD	NumType=Card	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	SL3	SL3	NUM	CD	NumType=Card	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2082
# text = The longest form, CBF beta-187, increased the transcriptional stimulation by CBF alpha 2-451 twofold in HeLa cells, although it had no effect in P19 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	longest	longest	ADJ	JJS	Degree=Sup	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	187	187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	ADV	RB	_	_	_	_	_
17	2-	2-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	451	451	NUM	CD	NumType=Card	_	_	_	_
19	twofold	twofold	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	although	although	SCONJ	IN	_	_	_	_	_
25	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	no	no	DET	DT	_	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	P19	P19	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2083
# text = Transcriptional activation by CBF beta required binding to the CBF alpha subunit, as a form of CBF beta that lacked binding ability, CBF beta-148, failed to increase activity.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
5	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
6	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	ability	ability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	148	148	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2084
# text = These results indicated that at least in certain cell types, the maximum activity of CBF required both subunits.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	at	at	ADV	RB	_	_	_	_	_
6	least	least	ADV	RBS	Degree=Sup	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
17	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2085
# text = They also provided support for the hypothesis that CBF is a factor in T lymphocytes that is responsible for recognition of the SL3 cores.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	provided	provide	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	support	support	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
24	cores	core	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2086
# text = We also examined whether CBF could distinguish a 1-bp difference between the enhancer core of SL3 and the core of the nonleukemogenic virus, Akv.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	distinguish	distinguish	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	core	core	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	core	core	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	nonleukemogenic	nonleukemogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Akv	Akv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2087
# text = This difference strongly affects transcription in T cells and leukemogenicity of SL3.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	leukemogenicity	leukemogenicity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	SL3	SL3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2088
# text = However, no combination of CBF alpha and CBF beta subunits that we tested was able to distinguish the 1-bp difference in transcription assays.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	distinguish	distinguish	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
23	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2089
# text = Thus, a complete understanding of how T cells recognize the SL3 core remains to be elucidated.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
5	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	how	how	ADV	WRB	PronType=Int	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
13	core	core	NOUN	NN	Number=Sing	_	_	_	_
14	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2090
# text = Document 003003129 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003129	003003129	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2091
# text = Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes.
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
13	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2092
# text = It has been demonstrated that interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) have various reverse effects on macrophages; however, the molecular mechanism of this difference has not been fully understood.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-gamma	-gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-10	-10	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
24	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
32	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	fully	fully	ADV	RB	_	_	_	_	_
40	understood	understand	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2093
# text = In this study, we analyzed the binding activity of IL-10- and IFN-gamma-activated
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 2094
# text = STAT molecules to two kinds of GAS-motif sequences.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	kinds	kind	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2095
# text = IL-10-activated STAT1 could bind to the GAS-motif sequence in the promoter region of the Fcgamma receptor, but not to that in the promoter region of the COX-2 gene, whereas IFN-gamma-activated STAT1 and STAT5 could bind to both sequences.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	GAS	gas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Fcgamma	Fcgamma	PROPN	NNP	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	COX	cox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	whereas	whereas	SCONJ	IN	_	_	_	_	_
40	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
47	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
48	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	both	both	DET	DT	_	_	_	_	_
51	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2096
# text = IL-10 inhibited IFN-gamma-induced STAT activation without newly synthesized protein.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IFN-	IFN-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	without	without	ADP	IN	_	_	_	_	_
12	newly	newly	ADV	RB	_	_	_	_	_
13	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2097
# text = We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma-induced STAT activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	dexamethasone	dexamethasone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2098
# text = Taken together, these results suggest that IL-10-activated STAT1 has a specificity in binding to the GAS-motif sequences, whereas IFN-gamma-activated STAT1 and STAT5 have a broader spectrum in binding to the GAS-motif sequences.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	STAT1	stat1	NOUN	NN	Number=Sing	_	_	_	_
14	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	SCONJ	IN	_	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	GAS	gas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
24	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	wherea	SCONJ	IN	_	_	_	_	_
27	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
34	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	broader	broader	ADJ	JJR	Degree=Cmp	_	_	_	_
37	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	SCONJ	IN	_	_	_	_	_
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	GAS	gas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
45	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2099
# text = This may explain the difference between IL-10 and IFN-gamma in biological activity, and the inhibitory effect of IL-10 on IFN-gamma activities.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
21	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2100
# text = Document 003003130 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003130	003003130	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2101
# text = Protein kinase inhibitor H-7 blocks accumulation of unspliced mRNA of human T-cell leukemia virus type I (HTLV-I).
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
4	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
8	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	unspliced	unspliced	ADJ	JJ	Degree=Pos	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2102
# text = Rex, the post-transcriptional regulator of human T-cell leukemia virus type I (HTLV-I), is known to induce accumulation of the unspliced viral gag-pol mRNA.
1	Rex	Rex	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	post	post	X	AFX	_	_	_	_	SpaceAfter=No
5	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
25	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	unspliced	unspliced	ADJ	JJ	Degree=Pos	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	gag	gag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
33	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2103
# text = Rex is a phosphoprotein found in the cell nucleolus, whose function may be regulated by its localization and phosphorylation.
1	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	nucleolus	nucleolus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2104
# text = We have examined the role of phosphorylation on Rex function by using a protein kinase inhibitor, H-7 [1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine].
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	7	7	NUM	CD	NumType=Card	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	1-(	1-(	SYM	NFP	_	_	_	_	SpaceAfter=No
23	5-isoquinolinyl-sulfonyl	5-isoquinolinyl-sulfonyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-methylpiperazine	-methylpiperazine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2105
# text = Treatment of an HTLV-I infected human T-cell line with H-7 blocked specifically accumulation of the unspliced gag-pol mRNA, resulting in the decreased Gag protein synthesis that corresponds with the decreased in vivo phosphorylation of Rex.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	infected	infect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	7	7	NUM	CD	NumType=Card	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	specifically	specifically	ADV	RB	_	_	_	_	_
18	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	unspliced	unspliced	ADJ	JJ	Degree=Pos	_	_	_	_
22	gag	gag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
25	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	Gag	Gag	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	corresponds	correspond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
41	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	Rex	Rex	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2106
# text = In contrast, other viral and cellular products have not been influenced by the level of H-7 used.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	products	product	NOUN	NNS	Number=Plur	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	7	7	NUM	CD	NumType=Card	_	_	_	_
20	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2107
# text = Therefore, the phosphorylation of Rex is required for the viral RNA partition of HTLV-I.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Rex	Rex	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	RNA	RNA	NOUN	NN	Number=Sing	_	_	_	_
13	partition	partition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2108
# text = Document 003003133 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003133	003003133	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2109
# text = G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes.
1	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
9	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
12	breakdown	breakdown	NOUN	NN	Number=Sing	_	_	_	_
13	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2110
# text = A study of the molecular mechanisms involved in inflammatory cytokine expression [published erratum appears in J Biol Chem 1994 Jun 17;269(24):16983]
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
15	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	J	j	PROPN	NNP	Number=Sing	_	_	_	_
18	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
19	Chem	Chem	PROPN	NNP	Number=Sing	_	_	_	_
20	1994	1994	NUM	CD	NumType=Card	_	_	_	_
21	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
22	17;269	17;269	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	24)	24)	SYM	NFP	_	_	_	_	SpaceAfter=No
25	:16983	:16983	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2111
# text = It is believed that induction of cytokine expression by bacterial cell wall components plays a role in the development and course of sepsis.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
13	components	component	NOUN	NNS	Number=Plur	_	_	_	_
14	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	course	course	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	sepsis	sepsis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2112
# text = However, most attention has been focused on lipopolysaccharide (LPS).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
4	attention	attention	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2113
# text = We studied the ability of N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-L-alanyl-D- isoglutamyl-m-diaminopimelyl-D-alanine (G(Anh)MTetra), a naturally occurring breakdown product of peptidoglycan that is produced by soluble lytic transglycosylase of Escherichia coli, to induce cytokine expression in human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	N-acetylglucosaminyl	N-acetylglucosaminyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-1,6-anhydro-N-acetylmuramyl-L-	-1,6-anhydro-N-acetylmuramyl-L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	alanyl	alanyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-D	-d	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	_
11	isoglutamyl	isoglutamyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	m-diaminopimelyl	m-diaminopimelyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-D-	-d-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	alanine	alanine	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	G	g	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	naturally	naturally	NOUN	NN	Number=Sing	_	_	_	_
26	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
27	breakdown	breakdown	ADP	IN	_	_	_	_	_
28	product	product	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	peptidoglycan	peptidoglycan	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
36	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	transglycosylase	transglycosylase	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
40	coli	coli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
44	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
45	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2114
# text = G(Anh)MTetra was found to strongly induce interleukin (IL)-1 beta and IL-6 mRNA expression after 2 h and IL-1 beta and IL-6 protein secretion after 48 h of activation.
1	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	strongly	strongly	ADV	RB	_	_	_	_	_
10	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	h	h	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
38	after	after	ADP	IN	_	_	_	_	_
39	48	48	NUM	CD	NumType=Card	_	_	_	_
40	h	h	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2115
# text = The increase in mRNA accumulation was at least partly due to an increase in the transcription rates of the respective genes and was accompanied by a strong induction of nuclear factor-kappa B and activator protein-1 transcription factor expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	partly	partly	ADV	RB	_	_	_	_	_
10	due	due	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	rates	rate	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2116
# text = Experiments using inhibitors of protein kinase C, protein kinase A, and tyrosine kinase-dependent pathways revealed that G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression involves activation of an H7-inhibitable pathway.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
19	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	H7	H7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-inhibitable	-inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
44	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2117
# text = By using the protein synthesis inhibitor cycloheximide, it was shown that G(Anh)MTetra-induced IL-6 mRNA expression depends on the synthesis of new protein, whereas G(Anh)MTetra-induced IL-1 beta mRNA accumulation does not.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	G	G	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	whereas	whereas	SCONJ	IN	_	_	_	_	_
34	G	G	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
45	mRNA	mRNa	SYM	SYM	_	_	_	_	_
46	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
47	does	do	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2118
# text = When responses to G(Anh)MTetra were compared with those to LPS and muramyldipeptide (MDP), it was found that the optimal response to G(Anh)MTetra induction was similar to that of LPS but significantly higher than the response to MDP.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	muramyldipeptide	muramyldipeptide	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	MDP	MDP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	LPS	LPS	NOUN	NN	Number=Sing	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	significantly	significantly	ADV	RB	_	_	_	_	_
43	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
44	than	than	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	_
47	to	to	ADP	IN	_	_	_	_	_
48	MDP	MDP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2119
# text = Furthermore, maximal G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression could be enhanced by co-stimulation with LPS or MDP, suggesting that different receptors and/or transduction pathways were involved.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
4	G	G	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	co-stimulation	co-stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	MDP	Mdp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
34	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	or	or	CCONJ	CC	_	_	_	_	_
38	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
39	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2120
# text = These results indicate that G(Anh)MTetra induces IL-1 beta and IL-6 expression in human monocytes suggesting a possible role for G(Anh)MTetra in the release of cytokines during sepsis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	release	release	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
38	during	during	ADP	IN	_	_	_	_	_
39	sepsis.	sepsis.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2121
# text = Document 003003134 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003134	003003134	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2122
# text = C/EBP beta in rheumatoid arthritis: correlation with inflammation, not disease specificity.
1	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
15	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2123
# text = Rheumatoid arthritis synovial tissue was examined and compared with osteoarthritis tissue for the presence of the nuclear transcription factor C/EBP beta (NF-IL-6).
1	Rheumatoid	Rheumatoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	arthritis	arthritis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	osteoarthritis	osteoarthritis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	C/	Cith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
21	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
22	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2124
# text = The region (lining or sublining), cell type, and subcellular distribution (cytoplasmic or nuclear) of the expression of C/EBP beta was characterized.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	lining	lin	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	sublining	sublin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	subcellular	subcelular	ADJ	JJ	Degree=Pos	_	_	_	_
14	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
27	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2125
# text = Rheumatoid arthritis synovial fluid and blood and normal peripheral blood were also examined.
1	Rheumatoid	Rheumatoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	arthritis	arthritis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
4	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2126
# text = C/EBP beta was detected in the synovial lining and in sublining cells of synovial tissue from patients with both rheumatoid and osteoarthritis.
1	C/	C/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
3	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
9	lining	lining	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	sublining	sublin	VERB	VBG	VerbForm=Ger	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
16	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	rheumatoid	rheumatoid	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	osteoarthritis	osteoarthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2127
# text = A significant (P < 0.001 and < 0.05, respectively) increase in the percentage of cells with nuclear staining was seen in the lining layer, compared to cells in the sublining region, in rheumatoid and osteoarthritis.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	P	p	NOUN	NN	Number=Sing	_	_	_	_
5	<	<	PUNCT	-LRB-	_	_	_	_	_
6	0.001	0.001	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	<	<	PUNCT	-LRB-	_	_	_	_	_
9	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	lining	lining	NOUN	NN	Number=Sing	_	_	_	_
27	layer	layer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	sublining	sublining	NOUN	NN	Number=Sing	_	_	_	_
35	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	rheumatoid	rheumatoid	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	osteoarthritis	osteoarthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2128
# text = In both diseases a strong correlation (r = 0.79, P < 0.001) was observed between the percentage of cells in the synovial lining that were positive for nuclear C/EBP beta and lining cell depth.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	r	be	NOUN	NN	Number=Sing	_	_	_	_
9	=	=	SYM	SYM	_	_	_	_	_
10	0.79	0.79	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	P	P	NOUN	NN	Number=Sing	_	_	_	_
13	<	<	PUNCT	-LRB-	_	_	_	_	_
14	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	between	between	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
26	lining	lining	NOUN	NN	Number=Sing	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	lining	lin	VERB	VBG	VerbForm=Ger	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	depth	depth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2129
# text = Two-color immunohistochemistry demonstrated that both macrophages and fibroblast-like synoviocytes were positive for nuclear C/EBP beta.
1	Two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	color	color	NOUN	NN	Number=Sing	_	_	_	_
4	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	SCONJ	IN	_	_	_	_	_
13	synoviocytes	synoviocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2130
# text = The presence of C/EBP beta was confirmed by immunohistochemistry and Western blot analysis with isolated synovial fibroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	immunohistochemistry	immunohistochemistry	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
14	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
15	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
19	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2131
# text = Nuclear C/EBP beta was also detected in rheumatoid synovial fluid monocytes/macrophages, but not in lymphocytes or neutrophils.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
4	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
11	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2132
# text = Western blot analysis confirmed the presence of C/EBP beta in these cells.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	confirmed	confirm	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2133
# text = The intensity of C/EBP beta staining was greater (P < 0.001) in synovial fluid monocytes than in those from normal or rheumatoid peripheral blood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	P	p	NOUN	NN	Number=Sing	_	_	_	_
13	<	<	PUNCT	-LRB-	_	_	_	_	_
14	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
18	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
28	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2134
# text = In conclusion, the enhanced nuclear staining for C/EBP beta in the synovial lining, compared to the sublining, suggesting activation in the lining, and the positive correlation of lining layer depth with the percentage of cells in the lining positive for nuclear C/EBP beta, suggest a potential role for C/EBP beta in chronic inflammation.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	nuclear	nuclear	NOUN	NN	Number=Sing	_	_	_	_
7	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
16	lining	lining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	sublining	sublining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lining	lining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	SCONJ	IN	_	_	_	_	_
34	lining	lin	VERB	VBG	VerbForm=Ger	_	_	_	_
35	layer	layer	NOUN	NN	Number=Sing	_	_	_	_
36	depth	depth	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	lining	lining	NOUN	NN	Number=Sing	_	_	_	_
45	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
48	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
50	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
51	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
54	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
55	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
56	role	role	NOUN	NN	Number=Sing	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
60	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
61	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
64	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2135
# text = The regulation of the production or activity of C/EBP beta, to inhibit inflammatory mediator expression by synovial macrophages and fibroblasts, offers a novel approach to therapeutic intervention.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
12	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	offers	offer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
28	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
31	intervention	intervention	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2136
# text = Document 003003138 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003138	003003138	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2137
# text = The activation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Jak-	Jak-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2138
# text = The intracellular signal transduction of IL-5 in eosinophils is unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2139
# text = The objective of this study was to investigate the involvement of the newly discovered Jak-STAT pathway in the IL-5 signal transduction mechanism.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	objective	objective	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	newly	newly	ADV	RB	_	_	_	_	_
14	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
25	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
26	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2140
# text = Eosinophils were purified from peripheral blood by discontinuous
1	Eosinophils	Eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	discontinuous	discontinuous	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2141
# text = Percoll gradients and stimulated with IL-5.
1	Percoll	Percoll	ADJ	JJ	Degree=Pos	_	_	_	_
2	gradients	gradient	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2142
# text = The involvement of Jak 2 was investigated by immunoprecipitation followed by immunoblotting for tyrosine phosphorylation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
10	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2143
# text = The activation of Jak 2 was studied by autophosphorylation of the immunoprecipitated kinase.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	autophosphorylation	autophosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	immunoprecipitated	immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2144
# text = Jak 2 was tyrosine phosphorylated within 1 to 3 min after stimulation of eosinophils with IL-5.
1	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
5	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	min	min	NOUN	NNS	Number=Plur	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2145
# text = Further, the immunoprecipitated Jak 2 obtained from IL-5-stimulated cells underwent autophosphorylation.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunoprecipitated	immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
16	autophosphorylation	autophosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2146
# text = Jak 2 coprecipitated with the beta-subunit of the IL-5 receptor, suggesting a physical association of the kinase with the receptor.
1	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	coprecipitated	coprecipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
19	association	association	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2147
# text = The nuclear factor STAT-1 (p91) was investigated by immunoprecipitation followed by immunoblotting for tyrosine phosphorylation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p91	p91	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
14	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2148
# text = STAT-1 was tyrosine phosphorylated within 15 min of IL-5 stimulation.
1	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	tyrosine	tyrosine	ADV	RB	_	_	_	_	_
6	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	15	15	NUM	CD	NumType=Card	_	_	_	_
9	min	min	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2149
# text = The presence of STAT-1 in the nuclear extract was studied by electrophoretic mobility shift assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
15	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2150
# text = IL-5 induced two proteins that bound to the gamma-activating sequence.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2151
# text = In the presence of an anti-STAT-1
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	anti-STAT	anti-stat	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2152
# text = Ab, the band was supershifted.
1	Ab	Ab	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	band	band	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	supershifted	supershift	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2153
# text = Thus, we demonstrated that IL-5 activated the Jak 2-STAT 1 signaling pathway in eosinophils.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
12	2-	2-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2154
# text = We speculate that the Jak 2-STAT 1 pathway may be involved in the activation of IL-5-inducible genes in eosinophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
6	2-	2-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2155
# text = Document 003003139 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003139	003003139	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2156
# text = Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation.
1	Retinoid	Retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	X	x	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
18	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha403	alpha403	NOUN	NN	Number=Sing	_	_	_	_
21	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	developmentally	developmentally	ADV	RB	_	_	_	_	_
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	myeloid	myeloid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2157
# text = The multiple biologic activities of retinoic acid (RA) are mediated through RAR and retinoid X receptor (RXR) nuclear receptors that interact with specific DNA target sequences as heterodimers (RXR-RAR) or homodimers (RXR-RXR).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
3	biologic	biologic	NOUN	NN	Number=Sing	_	_	_	_
4	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	X	x	ADP	IN	_	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	target	target	NOUN	NN	Number=Sing	_	_	_	_
30	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	RXR	Rxr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	RAR	Rar	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	RXR-	RXR-	X	AFX	_	_	_	_	SpaceAfter=No
42	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2158
# text = RA receptor activation appears critical to regulating important aspects of hematopoiesis, since transducing a COOH-terminally truncated RARalpha exhibiting dominant-negative activity (RARalpha403) into normal mouse bone marrow generates hematopoietic growth factor-dependent cell lines frozen at the multipotent progenitor (EML) or committed promyelocyte (MPRO) stages.
1	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	SCONJ	IN	_	_	_	_	_
7	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	SCONJ	IN	_	_	_	_	_
14	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	COOH	COOh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	terminally	terminally	ADV	RB	_	_	_	_	_
19	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	_
21	exhibiting	exhibite	VERB	VBG	VerbForm=Ger	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	RARalpha403	RARalpha403	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
32	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
33	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
34	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
36	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
42	frozen	freeze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	at	at	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	multipotent	multipotent	ADJ	JJ	Degree=Pos	_	_	_	_
46	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	EML	EML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	or	or	CCONJ	CC	_	_	_	_	_
51	committed	commit	ADJ	JJ	Degree=Pos	_	_	_	_
52	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	MPRO	MPRO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	_
56	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2159
# text = Nevertheless, relatively high, pharmacological concentrations of RA (1 to 10 &mgr;M) overcome these differentiation blocks and induce terminal granulocytic differentiation of the MPRO promyelocytes while potentiating interleukin-3 (IL-3)-induced commitment of EML cells to the granulocyte/monocyte lineage.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	relatively	relatively	ADV	RB	_	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
7	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	&	&	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	mgr	mgr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	SpaceAfter=No
17	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	overcome	overcome	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
26	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	MPRO	MPRO	PROPN	NNP	Number=Sing	_	_	_	_
31	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	while	while	SCONJ	IN	_	_	_	_	_
33	potentiating	potentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
34	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	3	3	NUM	CD	NumType=Card	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	EML	EML	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
52	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
53	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2160
# text = In the present study, we utilized RXR- and RAR-specific agonists and antagonists to determine how RA overcomes the dominant-negative activity of the truncated RARalpha in these different myeloid developmental stages.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	utilized	utilize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RAR-	RAR-	X	GW	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
18	how	how	ADV	WRB	PronType=Int	_	_	_	_
19	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
20	overcomes	overcome	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
34	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
35	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2161
# text = Unexpectedly, we observed that an RXR-specific, rather than an RAR-specific, agonist induces terminal granulocytic differentiation of MPRO promyelocytes, and this differentiation is associated with activation of DNA response elements corresponding to RAR-RXR heterodimers rather than RXR-RXR homodimers.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	RXR-specific	RXR-specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	rather	rather	ADV	RB	_	_	_	_	_
10	than	than	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	RAR-	rar-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
16	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	MPRO	MPRO	ADJ	JJ	Degree=Pos	_	_	_	_
22	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
35	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
40	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
41	rather	rather	ADV	RB	_	_	_	_	_
42	than	than	ADP	IN	_	_	_	_	_
43	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
46	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2162
# text = This RXR agonist activity is blocked by RAR-specific antagonists, suggesting extensive cross-talk between the partners of the RXR -RARalpha403 heterodimer.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	_
3	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	RAR-	RAR-	X	AFX	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
14	cross-talk	cross-talk	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	partners	partner	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	RXR	Rxr	PROPN	NNP	Number=Sing	_	_	_	_
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	RARalpha403	RARalpha403	NUM	CD	NumType=Card	_	_	_	_
23	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2163
# text = In contrast, in the more immature, multipotent EML cells we observed that this RXR-specific agonist is inactive either in potentiating IL-3-mediated commitment of EML cells to the granulocyte lineage or in transactivating RAR-RXR response elements.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	more	more	ADV	RBR	_	_	_	_	_
7	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	multipotent	multipotent	ADJ	JJ	Degree=Pos	_	_	_	_
10	EML	EML	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	RXR-	rxr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
21	either	either	CCONJ	CC	_	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	potentiating	potentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	EML	EML	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
36	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	in	in	SCONJ	IN	_	_	_	_	_
39	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
40	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
43	response	response	NOUN	NN	Number=Sing	_	_	_	_
44	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2164
# text = RA- triggered GALdbd-RARalpha hybrid activity in these cells indicates that the multipotent EML cells harbor substantial nuclear hormone receptor coactivator activity.
1	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	_
3	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	GALdbd	GALdbd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	multipotent	multipotent	ADJ	JJ	Degree=Pos	_	_	_	_
16	EML	eml	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	harbor	harbor	CCONJ	CC	_	_	_	_	_
19	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2165
# text = However, the histone deacetylase (HDAC) inhibitor trichostatin
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
5	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HDAC	HDAC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	trichostatin	trichostatin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2166
# text = A readily activates an RXR-RAR reporter construct in the multipotent EML cells but not in the committed MPRO promyelocytes, indicating that differences in HDAC-containing repressor complexes in these two closely related but distinct hematopoietic lineages might account for the differential activation of the RXR-RARalpha403 heterodimers that we observed at these different stages of myeloid development.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	readily	readily	NOUN	NN	Number=Sing	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	multipotent	multipotent	ADJ	JJ	Degree=Pos	_	_	_	_
13	EML	EML	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	committed	committed	ADJ	JJ	Degree=Pos	_	_	_	_
20	MPRO	Mpro	NOUN	NN	Number=Sing	_	_	_	_
21	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	HDAC	HDAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
30	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
31	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	two	two	NUM	CD	NumType=Card	_	_	_	_
35	closely	closely	ADV	RB	_	_	_	_	_
36	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
39	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
40	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
41	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
42	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	RXR-	rxr-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	RARalpha403	RARalpha403	NUM	CD	NumType=Card	_	_	_	_
51	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
52	that	that	PRON	WDT	PronType=Rel	_	_	_	_
53	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
54	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	at	at	ADP	IN	_	_	_	_	_
56	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
57	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
58	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
59	of	of	ADP	IN	_	_	_	_	_
60	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
61	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2167
# text = Document 003003143 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003143	003003143	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2168
# text = Decreased concentration of 1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with X-linked hypophosphatemic rickets: effect of phosphate supplementation.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
7	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
8	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	hypophosphatemic	hypophosphatemic	ADJ	JJ	Degree=Pos	_	_	_	_
20	rickets	ricket	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	phosphate	phosphate	ADJ	JJ	Degree=Pos	_	_	_	_
25	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2169
# text = Abnormal renal tubular phosphate transport is considered to be the primary defect in X-linked hypophosphatemic rickets (XLH).
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
3	tubular	tubular	NOUN	NN	Number=Sing	_	_	_	_
4	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
5	transport	transport	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
12	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	hypophosphatemic	hypophosphatemic	ADJ	JJ	Degree=Pos	_	_	_	_
18	rickets	ricket	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	XLH	XLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2170
# text = However, the resistance to vitamin D treatment in XLH cannot be explained by hypophosphatemia alone.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	vitamin	vitamin	VERB	VB	VerbForm=Inf	_	_	_	_
7	D	would	NOUN	NN	Number=Sing	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	XLH	XLH	PROPN	NNP	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
12	not	not	PART	RB	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	hypophosphatemia	hypophosphatemia	NOUN	NN	Number=Sing	_	_	_	_
17	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2171
# text = Since most of the actions of vitamin D are mediated by its receptors (VDR), abnormalities of VDR have been postulated in XLH.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
8	D	d	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	VDR	Vdr	PROPN	NNP	Number=Sing	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	XLH	XLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2172
# text = In order to investigate this possibility, we measured the concentration of VDR in PHA-activated peripheral mononuclear cells from 10 XLH patients.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	10	10	NUM	CD	NumType=Card	_	_	_	_
23	XLH	Xlh	ADJ	JJ	Degree=Pos	_	_	_	_
24	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2173
# text = Patients without phosphate supplementation showed significantly lower concentration (21.7 +/- 5.1 fmol/mg protein, mean +/- SEM) compared to the normal controls (60.7 +/- 4.0).
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	without	without	ADP	IN	_	_	_	_	_
3	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
4	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	significantly	significantly	ADV	RB	_	_	_	_	_
7	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
8	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	21.7	21.7	NUM	CD	NumType=Card	_	_	_	_
11	+/-	+/-	SYM	SYM	_	_	_	_	_
12	5.1	5.1	NUM	CD	NumType=Card	_	_	_	_
13	fmol	fmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	mean	mean	X	GW	_	_	_	_	_
19	+/-	+/-	X	GW	_	_	_	_	_
20	SEM	SEM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	controls	controls	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	60.7	60.7	NUM	CD	NumType=Card	_	_	_	_
29	+/-	+/-	SYM	SYM	_	_	_	_	_
30	4.0	4.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2174
# text = On the contrary, there was no significant difference between the phosphate-supplemented patients (58.3 +/- 2.7) and controls.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	there	there	PRON	EX	_	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
9	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	58.3	58.3	NUM	CD	NumType=Card	_	_	_	_
18	+/-	+/-	SYM	SYM	_	_	_	_	_
19	2.7	2.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2175
# text = There was a significant positive correlation between VDR concentration and serum phosphate (P less than 0.05).
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	VDR	Vdr	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	P	p	SYM	NFP	_	_	_	_	_
15	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2176
# text = In two patients, VDR was increased after daily phosphate supplementation was started.
1	In	in	ADP	IN	_	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	daily	daily	ADJ	JJ	Degree=Pos	_	_	_	_
10	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
11	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	started	start	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2177
# text = These results indicate that a decreased concentration of VDR secondary to persistent hypophosphatemia is one of the causes of vitamin D resistance in XLH.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
10	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
13	hypophosphatemia	hypophosphatemia	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
21	D	d	NOUN	NN	Number=Sing	_	_	_	_
22	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	XLH	XLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2178
# text = Document 003003144 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003144	003003144	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2179
# text = Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-C	-C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	Ets	Ets	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	temporally	temporally	ADV	RB	_	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2180
# text = A novel Ets protein was isolated by yeast one-hybrid screening of a cDNA library made from lipopolysaccharide-stimulated mouse splenic
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
3	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
9	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
12	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
16	library	library	NOUN	NN	Number=Sing	_	_	_	_
17	made	make	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
23	splenic	splenic	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2181
# text = B cells, using the SP6 kappa promoter kappaY element as a bait.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	SP6	Sp6	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	kappaY	kappay	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	bait	bait	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2182
# text = The novel Ets protein was most closely related to PU.1 and Spi-B within the DNA binding Ets domain and was therefore named Spi-C.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
4	protein	protein	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	most	most	ADV	RBS	_	_	_	_	_
7	closely	closely	ADV	RB	_	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	B	PROPN	NNP	Number=Sing	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	therefore	therefore	ADV	RB	_	_	_	_	_
24	named	name	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2183
# text = However, Spi-C may represent a novel subgroup within the Ets protein family, as it differed significantly from Spi-B and PU.1 within helix 1 of the Ets domain.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-C	-C	PROPN	NNP	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	subgroup	subgroup	NOUN	NN	Number=Sing	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	B	B	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
26	within	within	ADP	IN	_	_	_	_	_
27	helix	helix	NUM	CD	NumType=Card	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2184
# text = Spi-C was encoded by a single-copy gene that was mapped to chromosome 10, region C. Spi-C interacted with DNA similarly to PU.1 as judged by methylation interference, band-shift and site selection analysis, and activated transcription of a kappaY element reporter gene upon co-transfection of HeLa cells.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-C	-C	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	chromosome	chromosome	VERB	VB	VerbForm=Inf	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_
21	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	C	C	PROPN	NNP	Number=Sing	_	_	_	_
24	interacted	interact	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	similarly	similarly	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
30	as	as	SCONJ	IN	_	_	_	_	_
31	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	_
34	interference	interference	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	band	band	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	site	site	NOUN	NN	Number=Sing	_	_	_	_
41	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
42	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	kappaY	kappaY	PROPN	NNP	Number=Sing	_	_	_	_
50	element	element	NOUN	NN	Number=Sing	_	_	_	_
51	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
52	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	upon	upon	ADP	IN	_	_	_	_	_
54	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2185
# text = Spi-C RNA was expressed in mature B lymphocytes and at lower levels in macrophages.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-C	-C	PROPN	NNP	Number=Sing	_	_	_	_
3	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2186
# text = Furthermore, pre-B cell and plasma cell lines were Spi-C-negative, suggesting that Spi-C might be a regulatory molecule during a specific phase of B lymphoid development.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
4	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-C-	-C-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	C	C	PROPN	NNP	Number=Sing	_	_	_	_
20	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
32	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2187
# text = Document 003003147 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003147	003003147	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2188
# text = Expression of the nucleoside diphosphate kinase in human skin cancers: an immunohistochemical study.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nucleoside	nucleoside	ADJ	JJ	Degree=Pos	_	_	_	_
5	diphosphate	diphosphate	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
10	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	immunohistochemical	immunohistochemical	ADJ	JJ	Degree=Pos	_	_	_	_
14	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2189
# text = Expression of nucleoside diphosphate(NDP) kinase, which is homologous to the nm23 gene product in a variety of species, has been found to be inversely associated with metastatic potential.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nucleoside	nucleoside	ADJ	JJ	Degree=Pos	_	_	_	_
4	diphosphate	diphosphate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NDP	NDP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nm23	nm23	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	product	product	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	inversely	inversely	ADV	RB	_	_	_	_	_
30	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
33	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2190
# text = However, the relationship remains controversial according to the tumor cell types and experimental system, with conflicting results from different research groups.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
5	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	controversial	controversial	ADJ	JJ	Degree=Pos	_	_	_	_
7	according	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
15	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	with	with	SCONJ	IN	_	_	_	_	_
18	conflicting	conflicte	VERB	VBG	VerbForm=Ger	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	research	research	NOUN	NN	Number=Sing	_	_	_	_
23	groups	group	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2191
# text = In order to determine whether NDP kinase expression serves as a marker for metastatic potential in human skin cancer, we assessed the levels of NDP kinase expression in 9 keratoacanthomas (KAs), 26 squamous cell carcinomas (SCCs), and 25 basal cell carcinomas (BCCs) using immunohistochemistry.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	NDP	Ndp	PROPN	NNP	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
15	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
19	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	assessed	assess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NDP	Ndp	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	9	9	NUM	CD	NumType=Card	_	_	_	_
31	keratoacanthomas	keratoacanthoma	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	KAs	KAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	26	26	NUM	CD	NumType=Card	_	_	_	_
37	squamous	squamous	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	SCCs	SCC	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	25	25	NUM	CD	NumType=Card	_	_	_	_
46	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	BCCs	Bccs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
53	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2192
# text = The expression of NDP kinase was intense in KA and SCC compared with BCC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NDP	NDP	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	intense	intense	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	KA	KA	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	SCC	SCC	PROPN	NNP	Number=Sing	_	_	_	_
12	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	BCC	BCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2193
# text = However, the difference of NDP kinase expression between KA and SCC was not statistically significant.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NDP	NDP	PROPN	NNP	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	KA	KA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	SCC	SCC	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	statistically	statistically	ADV	RB	_	_	_	_	_
16	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2194
# text = And there was no statistically significant difference in NDP kinase expression between SCC with metastasis and SCC without metastasis.
1	And	and	CCONJ	CC	_	_	_	_	_
2	there	there	PRON	EX	_	_	_	_	_
3	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	statistically	statistically	ADV	RB	_	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	NDP	Ndp	PROPN	NNP	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	SCC	Scc	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	metastasis	metastasis	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	SCC	Scc	NOUN	NN	Number=Sing	_	_	_	_
18	without	without	ADP	IN	_	_	_	_	_
19	metastasis	metastasis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2195
# text = Our results contradict the hypothesis concerning the possible role of nm23 gene as a metastatic suppressor gene in human skin cancer.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	contradict	contradict	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	concerning	concern	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	nm23	nm23	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
16	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
21	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2196
# text = The mechanism of overexpression in various tumor cell types and its biological significance in cutaneous carcinogenesis remain to be determined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	types	type	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
13	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cutaneous	cutaneous	ADJ	JJ	Degree=Pos	_	_	_	_
16	carcinogenesis	carcinogenesis	NOUN	NN	Number=Sing	_	_	_	_
17	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2197
# text = Document 003003150 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003150	003003150	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2198
# text = Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease [see comments] BACKGROUND: Growing evidence indicates that the immune system and the hypothalamic-pituitary-adrenal system are linked by several mechanisms, for example intracellular glucocorticoid receptors (hGR).
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	colonic	colonic	ADJ	JJ	Degree=Pos	_	_	_	_
10	mucosa	mucosa	NOUN	NN	Number=Sing	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
23	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	see	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
28	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	Growing	growing	VERB	VBG	VerbForm=Ger	_	_	_	_
31	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
32	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
36	system	system	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
44	system	system	NOUN	NN	Number=Sing	_	_	_	_
45	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
49	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	for	for	ADP	IN	_	_	_	_	_
52	example	example	NOUN	NN	Number=Sing	_	_	_	_
53	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
54	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
55	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	hGR	hGR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2199
# text = Glucocorticoids are the standard treatment of acute attacks of inflammatory bowel disease (IBD).
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	standard	standard	ADJ	JJ	Degree=Pos	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
8	attacks	attack	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
12	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2200
# text = Binding of glucocorticoids to hGR down-regulates the transcription of inflammatory genes that can propagate IBD.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	hGR	hGR	VERB	VB	VerbForm=Inf	_	_	_	_
6	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	propagate	propagate	VERB	VB	VerbForm=Inf	_	_	_	_
17	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2201
# text = PATIENTS AND METHODS: IBD patients were either treated with 5-60 mg of prednisolone for more than 1 week or were without glucocorticoid treatment for more than 4 weeks.
1	PATIENTS	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	IBD	Ibd	ADJ	JJ	Degree=Pos	_	_	_	_
6	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	either	either	ADV	RB	_	_	_	_	_
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	prednisolone	prednisolone	PRON	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	week	week	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	without	without	ADP	IN	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	4	4	NUM	CD	NumType=Card	_	_	_	_
31	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2202
# text = hGR levels were determined from isolated cytosol of peripheral blood mononuclear cells (PBMCs) or mucosal biopsies using a radioassay with [3H]-dexamethasone.
1	hGR	hgr	ADJ	JJR	Degree=Cmp	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	mucosal	mucosal	ADJ	JJ	Degree=Pos	_	_	_	_
18	biopsies	biopsy	NOUN	NNS	Number=Plur	_	_	_	_
19	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	radioassay	radioassay	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2203
# text = Interleukin (IL) 6 levels were determined by enzyme-linked immunosorbent assay (ELISA).
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	immunosorbent	immunosorbent	ADJ	JJ	Degree=Pos	_	_	_	_
13	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2204
# text = RESULTS: The systemic (PBMC) hGR levels of corticosteroid-treated IBD patients were significantly lower than those of control subjects (59.6 +/- 57.1 dpm mg-1 cytosol protein vs. 227.0 +/- 90.8 dpm mg-1 cytosol protein, P = 0.007) and IBD patients not receiving glucocorticoid treatment (179.7 +/- 171.3 dpm mg-1 cytosol protein, P = 0.002).
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	systemic	systemic	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	corticosteroid	corticosteroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	IBD	ibd	PROPN	NNP	Number=Sing	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	control	control	NOUN	NN	Number=Sing	_	_	_	_
23	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	59.6	59.6	NUM	CD	NumType=Card	_	_	_	_
26	+/-	+/-	SYM	SYM	_	_	_	_	_
27	57.1	57.1	NUM	CD	NumType=Card	_	_	_	_
28	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
29	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	vs.	versus	ADP	IN	_	_	_	_	_
35	227.0	227.0	NUM	CD	NumType=Card	_	_	_	_
36	+/-	+/-	SYM	SYM	_	_	_	_	_
37	90.8	90.8	NUM	CD	NumType=Card	_	_	_	_
38	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
39	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
43	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	P	p	NOUN	NN	Number=Sing	_	_	_	_
46	=	=	SYM	SYM	_	_	_	_	_
47	0.007	0.007	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	_
51	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	not	not	PART	RB	_	_	_	_	_
54	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
55	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
56	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	179.7	179.7	NUM	CD	NumType=Card	_	_	_	_
59	+/-	+/-	SYM	SYM	_	_	_	_	_
60	171.3	171.3	NUM	CD	NumType=Card	_	_	_	_
61	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
62	mg	mg	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
63	-1	-1	NUM	CD	NumType=Card	_	_	_	_
64	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
65	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	,	,	PUNCT	,	_	_	_	_	_
67	P	p	NOUN	NN	Number=Sing	_	_	_	_
68	=	=	SYM	SYM	_	_	_	_	_
69	0.002	0.002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2205
# text = Systemic hGR levels in untreated IBD patients did not differ significantly from those in control subjects.
1	Systemic	Systemic	ADJ	JJ	Degree=Pos	_	_	_	_
2	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
6	IBD	Ibd	PROPN	NNP	Number=Sing	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2206
# text = In patients with connective tissue diseases, systemic hGR levels were also found to be decreased in the absence of glucocorticoid treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	connective	connective	ADJ	JJ	Degree=Pos	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
6	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
9	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2207
# text = Systemic hGR levels in patients with Crohn's disease (CD) treated with steroids (66.6 +/- 61.0 dpm mg-1 cytosol protein) were not different from those in patients with ulcerative colitis (UC) (56.1 +/- 51.6 dpm mg-1 cytosol protein).
1	Systemic	Systemic	ADJ	JJ	Degree=Pos	_	_	_	_
2	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	Crohn	Crohn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	treated	treat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	steroids	steroid	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	66.6	66.6	NUM	CD	NumType=Card	_	_	_	_
18	+/-	+/-	SYM	SYM	_	_	_	_	_
19	61.0	61.0	NUM	CD	NumType=Card	_	_	_	_
20	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
21	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	ulcerative	ulcerative	ADJ	JJ	Degree=Pos	_	_	_	_
36	colitis	colitis	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	UC	Uc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	56.1	56.1	NUM	CD	NumType=Card	_	_	_	_
42	+/-	+/-	SYM	SYM	_	_	_	_	_
43	51.6	51.6	NUM	CD	NumType=Card	_	_	_	_
44	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
45	mg	mg	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
46	-1	-1	NUM	CD	NumType=Card	_	_	_	_
47	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2208
# text = In contrast to these findings, mucosal hGR levels were significantly decreased in both steroid-treated (18.0 +/- 15.5) and not steroid-treated (37.8 +/- 30.5) patients compared with control subjects ( 125.6 +/- 97.1; P = 0.00009 and P = 0.0008 respectively ).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	mucosal	mucosal	ADJ	JJ	Degree=Pos	_	_	_	_
8	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	18.0	18.0	NUM	CD	NumType=Card	_	_	_	_
20	+/-	+/-	SYM	SYM	_	_	_	_	_
21	15.5	15.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	37.8	37.8	NUM	CD	NumType=Card	_	_	_	_
30	+/-	+/-	SYM	SYM	_	_	_	_	_
31	30.5	30.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
34	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	control	control	NOUN	NN	Number=Sing	_	_	_	_
37	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	_
39	125.6	125.6	NUM	CD	NumType=Card	_	_	_	_
40	+/-	+/-	SYM	SYM	_	_	_	_	_
41	97.1	97.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	P	p	NOUN	NN	Number=Sing	_	_	_	_
44	=	=	SYM	SYM	_	_	_	_	_
45	0.00009	0.00009	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	P	p	NOUN	NN	Number=Sing	_	_	_	_
48	=	=	SYM	SYM	_	_	_	_	_
49	0.0008	0.0008	NUM	CD	NumType=Card	_	_	_	_
50	respectively	respectively	ADV	RB	_	_	_	_	_
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2209
# text = IL-6 levels in all IBD groups with and without steroids were significantly different from those in control subjects.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	IBD	Ibd	ADJ	JJ	Degree=Pos	_	_	_	_
8	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	without	without	ADP	IN	_	_	_	_	_
12	steroids	steroid	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	significantly	significantly	ADV	RB	_	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2210
# text = CONCLUSION: In IBD there is no difference in systemic hGR levels between not steroid-treated patients and control subjects, in spite of inflammatory activity (IL-6).
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	_
5	there	there	ADV	RB	PronType=Dem	_	_	_	_
6	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
11	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	between	between	ADV	RB	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2211
# text = Mucosal hGR levels were decreased independently of treatment, probably leading to a decreased protection against NF-kappaB action in the intestinal mucosa.
1	Mucosal	Mucosal	ADJ	JJ	Degree=Pos	_	_	_	_
2	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	independently	independently	ADV	RB	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	probably	probably	ADV	RB	_	_	_	_	_
11	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
16	against	against	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	action	action	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
24	mucosa	mucosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2212
# text = Document 003003152 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003152	003003152	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2213
# text = Expression of tal-1 and GATA-binding proteins during human hematopoiesis.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2214
# text = Tal-1 rearrangements are associated with nearly 30% of human T acute lymphoblastic leukemia.
1	Tal	Tal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	nearly	nearly	ADV	RB	_	_	_	_	_
9	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	acute	acute	VERB	VB	VerbForm=Inf	_	_	_	_
15	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2215
# text = Tal-1 gene encodes a putative transcription factor with a basic helix-loop-helix domain and is known to be predominantly expressed in hematopoietic cells.
1	Tal	Tal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
13	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-helix	-helix	NOUN	NN	Number=Sing	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	predominantly	predominantly	ADV	RB	_	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2216
# text = We investigated the pattern of tal-1 expression in purified human hematopoietic cells by in situ hybridization and reverse transcriptase polymerase chain reaction analysis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
18	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
21	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	_
22	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
25	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2217
# text = Both methods demonstrated that the tal-1 gene is expressed in megakaryocytes and erythroblasts as well as in basophilic granulocytes.
1	Both	both	DET	DT	_	_	_	_	_
2	methods	method	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	basophilic	basophilic	ADJ	JJ	Degree=Pos	_	_	_	_
21	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2218
# text = In addition, our results indicate that the tal-1 1A promoter, which contains two consensus GATA-binding sites, is active mainly in these lineages.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
20	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
27	mainly	mainly	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2219
# text = Because the GATA-1 gene is known to transactivate several genes specific for the erythroid, megakaryocytic, and mastocytic/basophilic lineages, we studied GATA-1 expression in these purified hematopoietic cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	mastocytic	mastocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	basophilic	basophilic	ADJ	JJ	Degree=Pos	_	_	_	_
24	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
27	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2220
# text = We found that GATA-1 and tal-1 genes are coexpressed in these three lineages.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2221
# text = Remarkably, the expression of both genes is downmodulated during erythroid and megakaryocytic terminal maturation.
1	Remarkably	remarkably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	downmodulated	downmodulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
15	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2222
# text = In immature hematopoietic cells, tal-1 and GATA-1 genes are coexpressed in committed progenitors cells (CD34+/CD38(2+)), whereas they are not detectable in the most primitive cells (CD34(2+)/CD38-).
1	In	in	ADP	IN	_	_	_	_	_
2	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
3	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	committed	commit	ADJ	JJ	Degree=Pos	_	_	_	_
18	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CD34+/CD38	Cd34+/cd38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	2+	2+	SYM	SYM	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	whereas	whereas	SCONJ	IN	_	_	_	_	_
28	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	most	most	ADV	RBS	_	_	_	_	_
35	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CD34	CD34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	2+)	2+)	SYM	NFP	_	_	_	_	SpaceAfter=No
41	/CD38-)	/cd38-)	SYM	NFP	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2223
# text = In contrast, GATA-2 is strongly expressed in both most primitive and committed progenitors cells, whereas GATA-3 is mostly detected in most primitive ones.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	strongly	strongly	ADV	RB	_	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	most	most	ADV	RBS	_	_	_	_	_
13	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	committed	commit	ADJ	JJ	Degree=Pos	_	_	_	_
16	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	mostly	mostly	ADV	RB	_	_	_	_	_
25	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
28	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
29	ones	one	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2224
# text = Altogether our results strongly suggest that GATA-1 modulates the transcription of tal-1 during the differentiation of the erythroid, megakaryocytic, and basosophilic lineages.
1	Altogether	altogether	ADV	RB	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	modulates	modulate	NOUN	NNS	Number=Plur	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	basosophilic	basosophilic	ADJ	JJ	Degree=Pos	_	_	_	_
28	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2225
# text = Document 003003154 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003154	003003154	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2226
# text = Activation of human CD4 T lymphocytes.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2227
# text = Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	VLA	VLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2228
# text = Fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when CD4 cells were cultured with anti-CD3 alone or fibronectin alone.
1	Fibronectin	Fibronectin	PROPN	NNP	Number=Sing	_	_	_	_
2	synergized	synergize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
5	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
8	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
16	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
17	system	system	NOUN	NN	Number=Sing	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	no	no	DET	DT	_	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	when	when	ADV	WRB	PronType=Int	_	_	_	_
24	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
30	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	fibronectin	fibronectin	ADV	RB	_	_	_	_	_
33	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2229
# text = In addition, anti-CD29 (integrin beta 1) as well as anti-VLA-5 (human fibronectin receptor) antibodies blocked this CD4 cell activation in this system.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anti-CD29	anti-CD29	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	anti-VLA	anti-vla	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	5	5	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
22	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2230
# text = Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by CD4 cells, the combination of anti-CD3 plus fibronectin induced IL-2 message by CD4 cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	anti	anti	PRON	PRP	_	_	_	_	SpaceAfter=No
3	-CD3	-CD3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	fibronectin	fibronectin	ADV	RB	_	_	_	_	_
7	alone	alone	ADV	RB	_	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
9	not	not	PART	RB	_	_	_	_	_
10	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	message	message	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
23	plus	plus	CCONJ	CC	_	_	_	_	_
24	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	message	message	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2231
# text = In an analysis of the molecular mechanism by which IL-2 message was generated, we showed that a fibronectin-VLA-5 fibronectin receptor interaction may contribute an independent signal distinct from the CD3 pathway of activation by the induction of an AP-1 transcriptional factor.
1	In	in	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	message	message	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	VLA	VLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
33	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
34	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
38	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	_
49	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
50	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2232
# text = Thus the VLA-5 fibronectin receptor on CD4 cells can play a complementary role in CD3-TCR-mediated signal transduction through its interaction with fibronectin.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	VLA	VLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	CD3-TCR	CD3-TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
21	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2233
# text = Document 003003157 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003157	003003157	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2234
# text = Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations.
1	Daidzein	Daidzein	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	genistein	genistein	VERB	VB	VerbForm=Inf	_	_	_	_
4	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	weakly	weakly	ADV	RB	_	_	_	_	_
9	estrogenic	estrogenic	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	nutritionally	nutritionally	ADV	RB	_	_	_	_	_
18	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
19	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2235
# text = Daidzein and genistein glucuronides (DG and GG), major isoflavone metabolites, may be partly responsible for biological effects of isoflavones, such as estrogen receptor binding and natural killer cell (NK) activation or inhibition.
1	Daidzein	Daidzein	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	genistein	genistein	ADJ	JJ	Degree=Pos	_	_	_	_
4	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	GG	GG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	isoflavone	isoflavone	NOUN	NN	Number=Sing	_	_	_	_
13	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	partly	partly	ADV	RB	_	_	_	_	_
18	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	isoflavones	isoflavone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	estrogen	estrogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
32	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2236
# text = DG and GG were synthesized using 3-methylcholanthrene-induced rat liver microsomes.
1	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	methylcholanthrene-induced	methylcholanthrene-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
11	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
12	microsomes	microsome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2237
# text = The Km and Vmax for daidzein and genistein were 9.0 and 7.7 micromol/L, and 0.7 and 1.6 micromol/(mg protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Km	Km	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Vmax	Vmax	PROPN	NNP	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	daidzein	daidzein	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	9.0	9.0	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	7.7	7.7	NUM	CD	NumType=Card	_	_	_	_
13	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	0.7	0.7	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	1.6	1.6	NUM	CD	NumType=Card	_	_	_	_
19	micromol	micromol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2238
# text = min), respectively.
1	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2239
# text = The absence of ultraviolet absorbance maxima shifts in the presence of sodium acetate confirmed that the synthesized products were 7-O-glucuronides.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ultraviolet	ultraviolet	X	ADD	_	_	_	_	_
5	absorbance	absorbance	X	FW	Foreign=Yes	_	_	_	_
6	maxima	maxima	X	FW	Foreign=Yes	_	_	_	_
7	shifts	shift	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
13	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
14	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	synthesized	synthesized	ADJ	JJ	Degree=Pos	_	_	_	_
18	products	product	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2240
# text = DG and GG were further purified by a Sephadex LH-20 column.
1	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	further	further	ADV	RB	_	_	_	_	_
6	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Sephadex	Sephadex	PROPN	NNP	Number=Sing	_	_	_	_
10	LH	Lh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	20	20	NUM	CD	NumType=Card	_	_	_	_
13	column	column	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2241
# text = DG and GG competed with the binding of 17beta-(3H) estradiol to estrogen receptors of B6D2F1 mouse uterine cytosol.
1	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
4	competed	compete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	estrogen	estrogen	VERB	VB	VerbForm=Inf	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B6D2F1	B6D2F1	NOUN	NN	Number=Sing	_	_	_	_
21	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
22	uterine	uterine	NOUN	NN	Number=Sing	_	_	_	_
23	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2242
# text = The concentrations required for 50% displacement of 17beta-(3H) estradiol (CB50) were: 17beta-estradiol, 1.34 nmol/L; diethylstilbestrol, 1.46 nmol/L; daidzein, 1.6 micromol/L; DG, 14.7 micromol/L; genistein, 0.154 micromol/L; GG, 7.27 micromol/L.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	%	%	SYM	NN	Number=Sing	_	_	_	_
7	displacement	displacement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	17beta	17beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CB50	CB50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	were	be	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	1.34	1.34	NUM	CD	NumType=Card	_	_	_	_
26	nmol/L	nmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	diethylstilbestrol	diethylstilbestrol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	1.46	1.46	NUM	CD	NumType=Card	_	_	_	_
31	nmol/L	nmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	;	;	PUNCT	,	_	_	_	_	_
33	daidzein	daidzein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	1.6	1.6	NUM	CD	NumType=Card	_	_	_	_
36	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	DG	DG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	14.7	14.7	NUM	CD	NumType=Card	_	_	_	_
41	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	0.154	0.154	NUM	CD	NumType=Card	_	_	_	_
46	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	GG	GG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	7.27	7.27	NUM	CD	NumType=Card	_	_	_	_
51	micromol/L.	micromol/L.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2243
# text = In human peripheral blood NK cells, genistein at <0.5 micromol/L and DG and GG at 0.1-10 micromol/L enhanced NK cell-mediated K562 cancer cell killing significantly (P < 0.05).
1	In	in	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	genistein	genistein	ADJ	JJ	Degree=Pos	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
12	micromol/L	micromol/L	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	0.1	0.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	K562	k562	NUM	CD	NumType=Card	_	_	_	_
28	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	killing	killing	VERB	VBG	VerbForm=Ger	_	_	_	_
31	significantly	significantly	ADV	RB	_	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	P	p	NOUN	NN	Number=Sing	_	_	_	_
34	<	<	PUNCT	-LRB-	_	_	_	_	_
35	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2244
# text = At > 0.5 micromol/L, genistein inhibited NK cytotoxicity significantly (P < 0.05).
1	At	at	ADP	IN	_	_	_	_	_
2	>	>	PUNCT	-RRB-	_	_	_	_	_
3	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
4	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	genistein	genistein	ADV	WRB	PronType=Rel	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
9	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	P	p	NOUN	NN	Number=Sing	_	_	_	_
13	<	<	PUNCT	-LRB-	_	_	_	_	_
14	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2245
# text = The glucuronides only inhibited NK cytotoxicity at 50 micromol/L.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
6	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	50	50	NUM	CD	NumType=Card	_	_	_	_
9	micromol/L.	micromol/L.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2246
# text = Isoflavones, and especially the isoflavone glucuronides, enhanced activation of NK cells by interleukin-2 (IL-2), additively.
1	Isoflavones	Isoflavone	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	especially	especially	ADV	RB	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	isoflavone	isoflavone	ADJ	JJ	Degree=Pos	_	_	_	_
7	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	additively	additively	ADV	RB	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2247
# text = At physiological concentrations, DG and GG were weakly estrogenic, and they activated human NK cells in nutritionally relevant concentrations in vitro, probably at a site different from IL-2 action.
1	At	at	ADP	IN	_	_	_	_	_
2	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	weakly	weakly	ADV	RB	_	_	_	_	_
10	estrogenic	estrogenic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	nutritionally	nutritionally	ADV	RB	_	_	_	_	_
20	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
21	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	probably	probably	ADV	RB	_	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	_
29	different	different	NOUN	NN	Number=Sing	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2248
# text = Document 003003160 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003160	003003160	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2249
# text = The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	uniquely	uniquely	ADV	RB	_	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2250
# text = The TCF-1 gene encodes a putative transcription factor with affinity for a sequence motif occurring in a number of T-cell enhancers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
16	motif	motif	SCONJ	IN	_	_	_	_	_
17	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2251
# text = TCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of human and mouse cell lines.
1	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	originally	originally	ADV	RB	_	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	set	set	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	human	human	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2252
# text = In contrast, expression reportedly occurs in multiple nonlymphoid tissues during murine embryogenesis.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	reportedly	reportedly	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
13	embryogenesis	embryogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2253
# text = We have now raised a monoclonal antibody to document expression and biochemistry of the human TCF-1 protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
7	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	document	document	VERB	VB	VerbForm=Inf	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	biochemistry	biochemistry	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2254
# text = As expected, the TCF-1 protein was detectable only in cell lines of T lineage.
1	As	as	ADP	IN	_	_	_	_	_
2	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2255
# text = Its expression was always restricted to the nucleus.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	always	always	ADV	RB	_	_	_	_	_
5	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2256
# text = Immunohistochemistry on a panel of human tissues revealed that the TCF-1 protein was found exclusively in thymocytes and in CD3+ T cells in peripheral lymphoid tissues.
1	Immunohistochemistry	Immunohistochemistry	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	exclusively	exclusively	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+	+	SYM	SYM	_	_	_	_	_
24	T	t	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
28	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2257
# text = Western blotting yielded a set of bands ranging from 25 kD to 55 kD, resulting from extensive alternative splicing.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	yielded	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	set	set	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
8	ranging	rang	VERB	VBG	VerbForm=Ger	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	25	25	NUM	CD	NumType=Card	_	_	_	_
11	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	55	55	NUM	CD	NumType=Card	_	_	_	_
14	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
19	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
20	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2258
# text = The TCF-1 protein was detectable in all samples of a set of 22 T-cell malignancies of various stages of maturation, but was absent from a large number of other hematologic neoplasms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	set	set	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	22	22	NUM	CD	NumType=Card	_	_	_	_
16	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
21	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
31	number	number	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	hematologic	hematologic	ADJ	JJ	Degree=Pos	_	_	_	_
35	neoplasms	neoplasm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2259
# text = These observations imply a T cell-specific function for TCF-1, a notion corroborated by recent observations on Tcf-1 knock-out mice.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
17	corroborated	corroborate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
20	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	knock	knock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	out	out	NOUN	NN	Number=Sing	_	_	_	_
28	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2260
# text = In addition, these results indicate that nuclear TCF-1 expression can serve as a pan-T-lineage marker in the diagnosis of lymphoid malignancies.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	pan-T	pan-t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
20	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	diagnosis	diagnosis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2261
# text = Document 003003164 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003164	003003164	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2262
# text = Transient pseudo-hypoaldosteronism following resection of the ileum: normal level of lymphocytic aldosterone receptors outside the acute phase.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	pseudo	pseudo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-hypoaldosteronism	-hypoaldosteronism	NOUN	NN	Number=Sing	_	_	_	_
4	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
5	resection	resection	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	ileum	ileum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	outside	outside	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
19	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2263
# text = Pseudo-hypoaldosteronism (PHA) is due to mineralocorticoid resistance and manifests as hyponatremia and hyperkalemia with increased plasma aldosterone levels.
1	Pseudo-hypoaldosteronism	Pseudo-hypoaldosteronism	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	due	due	ADP	IN	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	mineralocorticoid	mineralocorticoid	NOUN	NN	Number=Sing	_	_	_	_
9	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	manifests	manifest	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	hyponatremia	hyponatremion	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	hyperkalemia	hyperkalemion	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
19	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2264
# text = It may be familial or secondary to abnormal renal sodium handling.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	familial	familial	ADJ	JJ	Degree=Pos	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
9	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
10	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
11	handling	handling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2265
# text = We report the case of a 54-year-old woman with multifocal cancer of the colon, who developed PHA after subtotal colectomy, ileal resection and jejunostomy.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	case	case	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	54	54	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	year	year	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	old	old	ADJ	JJ	Degree=Pos	_	_	_	_
12	woman	woman	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	multifocal	multifocal	ADJ	JJ	Degree=Pos	_	_	_	_
15	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	colon	colon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	who	who	PRON	WP	PronType=Rel	_	_	_	_
21	developed	develope	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
23	after	after	ADP	IN	_	_	_	_	_
24	subtotal	subtotal	ADJ	JJ	Degree=Pos	_	_	_	_
25	colectomy	colectomy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	ileal	ileal	ADJ	JJ	Degree=Pos	_	_	_	_
28	resection	resection	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	jejunostomy	jejunostomy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2266
# text = She was treated with 6 g of salt daily to prevent dehydration, which she stopped herself because of reduced fecal losses.
1	She	she	PRON	PRP	Case=Nom|Gender=Fem|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	g	g	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
9	daily	daily	ADV	RB	_	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
12	dehydration	dehydration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	she	she	PRON	PRP	Case=Nom|Gender=Fem|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	stopped	stop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	herself	herself	PRON	PRP	Case=Acc|Gender=Fem|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
18	because	because	ADP	IN	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	fecal	fecal	ADJ	JJ	Degree=Pos	_	_	_	_
22	losses	loss	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2267
# text = One month later she was admitted with signs of acute adrenal failure, i.e. fatigue, severe nausea, blood pressure of 80/60 mmHg, extracellular dehydration, hyponatremia (118 mmol/l); hyperkalemia (7.6 mmol/l), increased blood urea nitrogen (BUN) (200 mg/dl) and creatininemia (2.5 mg/dl), and decreased plasma bicarbonates level (HCO3-: 16 mmol/l; N: 27-30).
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	month	month	NOUN	NN	Number=Sing	_	_	_	_
3	later	later	ADV	RB	_	_	_	_	_
4	she	she	PRON	PRP	Case=Nom|Gender=Fem|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	admitted	admit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	signs	sign	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
12	failure	failure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	i.e.	i.e.	X	FW	_	_	_	_	_
15	fatigue	fatigue	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
18	nausea	nausea	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	pressure	pressure	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	80/60	80/60	NUM	CD	NumType=Card	_	_	_	_
24	mmHg	mmHg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	extracellular	extracelular	ADJ	JJ	Degree=Pos	_	_	_	_
27	dehydration	dehydration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	hyponatremia	hyponatremia	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	118	118	NUM	CD	NumType=Card	_	_	_	_
32	mmol	mmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	l	l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	;	;	PUNCT	,	_	_	_	_	_
37	hyperkalemia	hyperkalemia	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	7.6	7.6	NUM	CD	NumType=Card	_	_	_	_
40	mmol/	mmol/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	l	l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
46	urea	urea	NOUN	NN	Number=Sing	_	_	_	_
47	nitrogen	nitrogen	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	BUN	bun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	200	200	NUM	CD	NumType=Card	_	_	_	_
53	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
55	dl	dl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	creatininemia	creatininemia	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	2.5	2.5	NUM	CD	NumType=Card	_	_	_	_
61	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	/dl	/dl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
67	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
68	bicarbonates	bicarbonate	NOUN	NNS	Number=Plur	_	_	_	_
69	level	level	NOUN	NN	Number=Sing	_	_	_	_
70	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
71	HCO	HCo	INTJ	UH	_	_	_	_	SpaceAfter=No
72	3-:	3-:	PUNCT	,	_	_	_	_	_
73	16	16	NUM	CD	NumType=Card	_	_	_	_
74	mmol/l	mmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	;	;	PUNCT	,	_	_	_	_	_
76	N	and	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	:	:	PUNCT	:	_	_	_	_	_
78	27	27	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	-30	-30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
80	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
81	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2268
# text = However, the plasma cortisol was high (66 microg/100 ml at 10:00 h; N: 8-15) and the ACTH was normal (13 pg/ml, N: 10-60); there was a marked increase in plasma renin activity (>37 ng/ml/h; N supine <3), active renin (869 pg/ml; N supine: 1.120), aldosterone (>2000 pg/ml; N supine <150) and plasma AVP (20 pmol/l; N: 0.5-2.5).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
5	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	66	66	NUM	CD	NumType=Card	_	_	_	_
10	microg	microg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/100	/100	NUM	CD	NumType=Card	_	_	_	_
12	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	10:00	10:00	NUM	CD	NumType=Card	_	_	_	_
15	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	_
17	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ACTH	ACth	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	13	13	NUM	CD	NumType=Card	_	_	_	_
30	pg/ml	pg/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	N	N	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
33	:	:	PUNCT	:	_	_	_	_	_
34	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-60	-60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	there	there	PRON	EX	_	_	_	_	_
39	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
45	renin	renin	NOUN	NN	Number=Sing	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	>37	>37	NUM	CD	NumType=Card	_	_	_	_
49	ng/ml/h	ng/ml/h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	;	;	PUNCT	,	_	_	_	_	_
51	N	and	CCONJ	CC	Abbr=Yes	_	_	_	_
52	supine	supine	NOUN	NN	Number=Sing	_	_	_	_
53	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
58	renin	renin	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	869	869	NUM	CD	NumType=Card	_	_	_	_
61	pg	pg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
63	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	;	;	PUNCT	,	_	_	_	_	_
65	N	and	CCONJ	CC	Abbr=Yes	_	_	_	_
66	supine	supine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	:	:	PUNCT	:	_	_	_	_	_
68	1.120	1.120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
70	,	,	PUNCT	,	_	_	_	_	_
71	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
72	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
73	>2000	>2000	NUM	CD	NumType=Card	_	_	_	_
74	pg	pg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
76	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	;	;	PUNCT	,	_	_	_	_	_
78	N	and	CCONJ	CC	Abbr=Yes	_	_	_	_
79	supine	supine	NOUN	NN	Number=Sing	_	_	_	_
80	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
81	150	150	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
82	)	)	PUNCT	-RRB-	_	_	_	_	_
83	and	and	CCONJ	CC	_	_	_	_	_
84	plasma	plasma	PROPN	NNP	Number=Sing	_	_	_	_
85	AVP	AVP	PROPN	NNP	Number=Sing	_	_	_	_
86	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
87	20	20	NUM	CD	NumType=Card	_	_	_	_
88	pmol/l	pmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
89	;	;	PUNCT	,	_	_	_	_	_
90	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
91	:	:	PUNCT	:	_	_	_	_	_
92	0.5	0.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
93	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
94	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
95	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
96	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2269
# text = The plasma ANH level was 38 pmol/l (N supine: 5-25).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
3	ANH	ANh	DET	DT	_	_	_	_	_
4	level	level	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	38	38	NUM	CD	NumType=Card	_	_	_	_
7	pmol/	pmol/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	l	l	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	N	not	CCONJ	CC	Abbr=Yes	_	_	_	_
11	supine	supine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2270
# text = A urinary steroidogram resulted in highly elevated tetrahydrocortisol (THF: 13.3 mg/24h; N: 1.4+/-0.8) with no increase in tetrahydrocortisone (THE: 3.16 mg/24h; N: 2.7+/-2.0) excretion, and with low THE/THF (0.24; N: 1.87+/-0.36) and alpha THF/THF (0.35; N: 0.92+/-0.42) ratios.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
3	steroidogram	steroidogram	NOUN	NN	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	tetrahydrocortisol	tetrahydrocortisol	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	THF	Thf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	13.3	13.3	NUM	CD	NumType=Card	_	_	_	_
13	mg/24h	mg/24h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	1.4+/-	1.4+/-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	0.8	0.8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	tetrahydrocortisone	tetrahydrocortisone	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	THE	the	DET	DT	Definite=Def|PronType=Art	_	_	_	SpaceAfter=No
27	:	:	PUNCT	:	_	_	_	_	_
28	3.16	3.16	NUM	CD	NumType=Card	_	_	_	_
29	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/24h	/24h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
33	:	:	PUNCT	:	_	_	_	_	_
34	2.7+/-	2.7+/-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	2.0	2.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	excretion	excretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
42	THE	the	DET	DT	Definite=Def|PronType=Art	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	THF	Thf	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	0.24	0.24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
49	:	:	PUNCT	:	_	_	_	_	_
50	1.87+/-0.36	1.87+/-0.36	X	LS	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
54	THF	THF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
56	THF	THF	PROPN	NNP	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	0.35	0.35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	;	;	PUNCT	,	_	_	_	_	_
60	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
61	:	:	PUNCT	:	_	_	_	_	_
62	0.92+/-	0.92+/-	SYM	SYM	_	_	_	_	SpaceAfter=No
63	0.42	0.42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	ratios	ratio	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2271
# text = The number of mineralocorticoid receptors in mononuclear leukocytes was in the lower normal range for age, while the number of glucocorticoid receptors was reduced.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mineralocorticoid	mineralocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	range	range	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2272
# text = Small-bowel resection in ileostomized patients causes excessive fecal sodium losses and results in chronic sodium depletion with contraction of the plasma volume and severe secondary hyperaldosteronism.
1	Small	small	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
4	resection	resection	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	ileostomized	ileostomize	ADJ	JJ	Degree=Pos	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
9	excessive	excessive	ADJ	JJ	Degree=Pos	_	_	_	_
10	fecal	fecal	ADJ	JJ	Degree=Pos	_	_	_	_
11	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
12	losses	loss	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
17	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
18	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	contraction	contraction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
24	volume	volume	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
27	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
28	hyperaldosteronism	hyperaldosteronism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2273
# text = Nevertheless, this hyperaldosteronism may be associated with hyponatremia and hyperkalemia suggesting PHA related to the major importance of the colon for the absorption of sodium.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	hyperaldosteronism	hyperaldosteronism	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	hyponatremia	hyponatremia	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	hyperkalemia	hyperkalemia	NOUN	NN	Number=Sing	_	_	_	_
12	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	PHA	Pha	PROPN	NNP	Number=Sing	_	_	_	_
14	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
18	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	colon	colon	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	absorption	absorption	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2274
# text = In conclusion, this case report emphasizes 1) the possibility of a syndrome of acquired PHA with severe hyperkalemia after resection of the ileum and colon responding to oral salt supplementation; 2) the major increase in AVP and the small increase in ANH; 3) the strong increase in urinary THF with low THE/THF and alpha THF/THF ratios; 4) the normal number of lymphocytic mineralocorticoid receptors outside the acute episode.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	case	case	NOUN	NN	Number=Sing	_	_	_	_
6	report	report	NOUN	NN	Number=Sing	_	_	_	_
7	emphasizes	emphasize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	1	1	X	LS	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	acquired	acquired	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
20	hyperkalemia	hyperkalemia	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	resection	resection	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ileum	ileum	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	colon	colon	NOUN	NN	Number=Sing	_	_	_	_
28	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	oral	oral	ADJ	JJ	Degree=Pos	_	_	_	_
31	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
32	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	;	;	PUNCT	,	_	_	_	_	_
34	2	2	X	LS	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
38	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	AVP	AVP	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
44	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	ANH	ANH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	3	3	X	LS	_	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
52	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
55	THF	Thf	NOUN	NN	Number=Sing	_	_	_	_
56	with	with	ADP	IN	_	_	_	_	_
57	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
58	THE	the	DET	DT	Definite=Def|PronType=Art	_	_	_	SpaceAfter=No
59	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
60	THF	THF	PROPN	NNP	Number=Sing	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
63	THF	THF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
65	THF	Thf	NOUN	NN	Number=Sing	_	_	_	_
66	ratios	ratio	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
67	;	;	PUNCT	,	_	_	_	_	_
68	4	4	X	LS	_	_	_	_	SpaceAfter=No
69	)	)	PUNCT	-RRB-	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
72	number	number	NOUN	NN	Number=Sing	_	_	_	_
73	of	of	ADP	IN	_	_	_	_	_
74	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
75	mineralocorticoid	mineralocorticoid	NOUN	NN	Number=Sing	_	_	_	_
76	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
77	outside	outside	ADP	IN	_	_	_	_	_
78	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
79	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
80	episode	episode	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2275
# text = Document 003003169 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003169	003003169	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2276
# text = Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.
1	Genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	erythropoietin	erythropoietin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
13	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2277
# text = Erythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	EPOR	Epor	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2278
# text = After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression.
1	After	after	SCONJ	IN	_	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	EPOR	Epor	PROPN	NNP	Number=Sing	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	ultimately	ultimately	ADV	RB	_	_	_	_	_
16	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2279
# text = Although erythroid progenitors appear to be the principal EPO-responsive cell type in vivo due to the restricted expression of the EPOR, many growth factor-dependent cell lines expressing the EPOR can respond to EPO by activating many or all of these pathways.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
4	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	principal	principal	NOUN	NN	Number=Sing	_	_	_	_
9	EPO	Epo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
32	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	_
35	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
36	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
39	by	by	SCONJ	IN	_	_	_	_	_
40	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
41	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	all	all	DET	DT	_	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
46	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2280
# text = In the present study, we have identified a cellular context (the interleukin-2 [IL-2]-dependent HT-2 line) in which the EPO stimulation of the EPOR fails to support cellular proliferation, STAT-5 induction, or MAPK activation, despite efficient phosphorylation of the EPOR and JAK2 and inhibition of apoptosis after withdrawal of IL-2.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	context	context	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	HT	Ht	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	EPOR	EPOR	PROPN	NNP	Number=Sing	_	_	_	_
37	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	support	support	VERB	VB	VerbForm=Inf	_	_	_	_
40	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
41	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	5	5	NUM	CD	NumType=Card	_	_	_	_
46	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	or	or	CCONJ	CC	_	_	_	_	_
49	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	despite	despite	ADP	IN	_	_	_	_	_
53	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
54	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	JAK2	Jak2	NOUN	NN	Number=Sing	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
64	after	after	ADP	IN	_	_	_	_	_
65	withdrawal	withdrawal	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2281
# text = Interestingly, when we fused HT-2 cells expressing the EPOR with Ba/F3 cells in a complementation assay, the resulting hybridomas proliferated and potently activated STAT-5 and MAPK in response to EPO.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	fused	fuse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	HT	HT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Ba/F3	Ba/F3	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
23	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	_
24	proliferated	proliferate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	potently	potently	ADV	RB	_	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	5	5	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2282
# text = These data indicate that an unidentified cellular factor is needed to mediate signaling by the EPOR.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
7	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
13	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2283
# text = Moreover, Ba/F3 cells apparently express this factor(s) and somatic fusions can, therefore, confer EPO-responsiveness to HT-2 cells that lack this factor.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Ba/F3	Ba/F3	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	apparently	apparently	ADV	RB	_	_	_	_	_
6	express	express	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	s	s	X	AFX	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
14	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	confer	confer	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
20	EPO	Epo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	HT	HT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2284
# text = Document 003003171 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003171	003003171	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2285
# text = Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	STAT	Stat	VERB	VB	VerbForm=Inf	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2286
# text = The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	recently	recently	ADV	RB	_	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
33	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2287
# text = IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	rapid	rapid	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	concomitantly	concomitantly	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2288
# text = STAT proteins.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2289
# text = The
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_

# sent_id = 2290
# text = STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2291
# text = Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7, suggesting that this signal transduction mechanism may play a key role in IL-7-induced proliferation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	STAT	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	strongly	strongly	ADV	RB	_	_	_	_	_
17	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
33	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
34	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
39	role	role	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2292
# text = Document 003003172 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003172	003003172	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2293
# text = Tyrosine kinase and cAMP-dependent protein kinase activities in CD40-activated human B lymphocytes.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2294
# text = In vitro, human B lymphocytes undergo long-term proliferation when activated through CD40, a protein expressed on their cell surface.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	undergo	undergo	ADV	RB	_	_	_	_	_
8	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	term	term	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2295
# text = The nature of CD40-dependent signals in proliferating fresh human Epstein-Barr virus-negative B lymphocytes is currently unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	proliferating	proliferate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	fresh	fresh	ADV	RB	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	currently	currently	ADV	RB	_	_	_	_	_
22	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2296
# text = In this study, a CD40-dependent B cell culture system was used to examine the role of different signal transduction elements.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
22	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
23	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2297
# text = Protein kinase C (PKC) depletion generated by a long-term phorbol 12 myristate 13-acetate treatment had weak effects on proliferation.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
8	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	term	term	NOUN	NN	Number=Sing	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	12	12	NUM	CD	NumType=Card	_	_	_	_
16	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
17	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
21	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2298
# text = Rather, tyrosine phosphorylation was shown to be directly involved in mediating CD40-dependent signals.
1	Rather	Rather	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	directly	directly	ADV	RB	_	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2299
# text = The use of the protein tyrosine kinase (PTK)-specific inhibitor herbimycin A dramatically decreased cellular proliferation without altering the activity of the human immunodeficiency virus-1 long terminal repeat (HIV-1 LTR), a promoter largely dependent on the binding of nuclear factor kappa B (NF- kappa B).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	use	use	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	X	GW	_	_	_	_	_
16	dramatically	dramatically	ADV	RB	_	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	without	without	SCONJ	IN	_	_	_	_	_
21	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
28	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
32	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
33	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	largely	largely	ADV	RB	_	_	_	_	_
44	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
50	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
51	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
52	B	b	NOUN	NN	Number=Sing	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	_
56	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
57	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2300
# text = In contrast, the cAMP-dependent protein kinase specific inhibitor H-89 totally inhibited HIV-1 LTR activity at a concentration as low as 100 nM without affecting cellular proliferation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
12	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	89	89	NUM	CD	NumType=Card	_	_	_	_
15	totally	totally	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADV	RB	_	_	_	_	_
26	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	100	100	NUM	CD	NumType=Card	_	_	_	_
29	nM	nm	NOUN	NN	Number=Sing	_	_	_	_
30	without	without	SCONJ	IN	_	_	_	_	_
31	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
32	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
33	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2301
# text = Electrophoretic mobility shift assay (EMSA) and supershift assay using an NF-kappa B binding sequence from the kappa light chain as a probe, revealed that both p65 (RelA) and c-Rel were present in CD40-stimulated B cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	supershift	supershift	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
10	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	light	light	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
44	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2302
# text = While PKC depletion did not alter the NF-kappa B level, treatment of B lymphocytes with H-89 or herbimycin A provoked a decrease in the NF-kappa B level.
1	While	while	SCONJ	IN	_	_	_	_	_
2	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
3	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	89	89	NUM	CD	NumType=Card	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
24	A	and	NOUN	NN	Number=Sing	_	_	_	_
25	provoked	provoke	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2303
# text = These observations establish the importance of different signal transducing pathways leading to CD40 activation of B lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2304
# text = Document 003003176 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003176	003003176	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2305
# text = Effects of 1 alpha, 25-dihydroxyvitamin D3 on the human chronic myelogenous leukemia cell line RWLeu-4.
1	Effects	Effects	PROPN	NNPS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
9	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
14	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	RWLeu	RWLeu	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2306
# text = The effects of 1 alpha, 25-dihydroxyvitamin D3 (VD3) on proliferation, differentiation, and macromolecular synthesis in the new Philadelphia chromosome-positive chronic myelogenous leukemia cell line, RWLeu-4, were investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
10	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	VD3	VD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	macromolecular	macromolecular	ADJ	JJ	Degree=Pos	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
25	Philadelphia	Philadelphia	PROPN	NNP	Number=Sing	_	_	_	_
26	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
30	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
31	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2307
# text = Binding of [3H]VD3 was saturable, with approximately 2000-3000 sites/cell, and half-maximal binding occurring at 0.21-0.33 nM.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	3H]	3h]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	VD3	VD3	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	saturable	saturable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	approximately	approximately	ADV	RB	_	_	_	_	_
11	2000	2000	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	3000	3000	NUM	CD	NumType=Card	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	half	half	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
22	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
23	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	0.21	0.21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	0.33	0.33	NUM	CD	NumType=Card	_	_	_	_
28	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2308
# text = Treatment of RWLeu-4 cells with VD3 induced 24R-hydroxylase activity, a marker of vitamin D3 responsiveness in many tissues.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	24R	24r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
19	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
20	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
23	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2309
# text = Exposure of RWLeu-4 cells to VD3 also inhibited proliferation and DNA synthesis with a 50% effective dose of 3.5-10 nM within 72 h; in addition, protein and RNA synthesis were inhibited by VD3 treatment.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	3.5	3.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	10	10	NUM	CD	NumType=Card	_	_	_	_
25	nM	nm	NUM	CD	NumType=Card	_	_	_	_
26	within	within	ADP	IN	_	_	_	_	_
27	72	72	NUM	CD	NumType=Card	_	_	_	_
28	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
29	;	;	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
36	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
41	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2310
# text = Exposure of RWLeu-4 cells to 5 nM VD3 for 72 h caused 50% of the cells to differentiate into macrophage/monocyte type cells as judged by nitroblue tetrazolium staining and adherence to plastic.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	nM	nm	NUM	CD	NumType=Card	_	_	_	_
10	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	72	72	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	_
14	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
22	into	into	ADP	IN	_	_	_	_	_
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
26	type	type	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	as	as	SCONJ	IN	_	_	_	_	_
29	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	nitroblue	nitroblue	NOUN	NN	Number=Sing	_	_	_	_
32	tetrazolium	tetrazolium	NOUN	NN	Number=Sing	_	_	_	_
33	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2311
# text = Progressive expression of cell surface maturation-specific antigens of the monocyte/macrophage lineage was induced by treatment of RWLeu-4 cells with VD3 for 24 to 72 h at doses that inhibited cellular proliferation.
1	Progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
15	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	24	24	NUM	CD	NumType=Card	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	72	72	NUM	CD	NumType=Card	_	_	_	_
31	h	h	NOUN	NN	Number=Sing	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
37	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2312
# text = c-myc RNA, which is constitutively expressed in RWLeu-4 cells, increased after 0.5 h of treatment with 50 nM VD3 and then rapidly decreased to barely detectable levels after 4 h of treatment.
1	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	_
2	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	constitutively	constitutively	ADV	RB	_	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-4	-4	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
16	h	h	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	50	50	NUM	CD	NumType=Card	_	_	_	_
21	nM	nm	NOUN	NN	Number=Sing	_	_	_	_
22	VD3	VD3	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	then	then	ADV	RB	PronType=Dem	_	_	_	_
25	rapidly	rapidly	ADV	RB	_	_	_	_	_
26	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	barely	barely	ADV	RB	_	_	_	_	_
29	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	h	h	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2313
# text = Finally, the in vitro tyrosine kinase activity associated with the p210bcr-abl oncogene product was decreased approximately 50% by VD3 treatment.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	p210	p210	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	bcr-abl	bcr-abl	NOUN	NN	Number=Sing	_	_	_	_
14	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
15	product	product	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	approximately	approximately	ADV	RB	_	_	_	_	_
19	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	%	%	SYM	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2314
# text = Because of the presence of a functional receptor-effector system for VD3 and multiple biological responses to the hormone, these cells provide a unique model system with which to probe the specific effects of VD3 on cell growth and differentiation in chronic myelogenous leukemia.
1	Because	because	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
11	system	system	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
17	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
27	model	model	NOUN	NN	Number=Sing	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	probe	probe	VERB	VB	VerbForm=Inf	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	VD3	VD3	NOUN	NN	Number=Sing	_	_	_	_
38	on	on	ADP	IN	_	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
45	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
46	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2315
# text = Document 003003178 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003178	003003178	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2316
# text = Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	abrogation	abrogation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	pure	pure	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiating	differentiating	VERB	VBG	VerbForm=Ger	_	_	_	_
18	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
19	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2317
# text = The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	yet	yet	ADV	RB	_	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2318
# text = The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	maturing	mature	ADJ	JJ	Degree=Pos	_	_	_	_
23	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2319
# text = We analyzed GATA-1 expression in early human adult hematopoiesis by using an in vitro system in which "pure" early hematopoietic progenitors are induced to gradual and synchronized differentiation selectively along the erythroid or granulocyte-macrophage pathway by differential treatment with hematopoietic growth factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
11	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
17	system	system	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
21	pure	pure	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	"	"	PUNCT	''	_	_	_	_	_
23	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	gradual	gradual	VERB	VB	VerbForm=Inf	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	synchronized	synchronize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
33	selectively	selectively	ADV	RB	_	_	_	_	_
34	along	along	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
41	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
44	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
47	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
48	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2320
# text = The GATA-1 gene, though virtually silent in quiescent progenitors, is activated after entrance into the cell cycle upon stimulation with hematopoietic growth factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	though	though	SCONJ	IN	_	_	_	_	_
8	virtually	virtually	ADV	RB	_	_	_	_	_
9	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
12	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	entrance	entrance	NOUN	NN	Number=Sing	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
22	upon	upon	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2321
# text = Subsequently, increasing expression along the erythroid pathway contrasts with an abrupt downregulation in the granulocyte-macrophage lineage.
1	Subsequently	subsequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	along	along	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	contrasts	contrast	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	abrupt	abrupt	ADJ	JJ	Degree=Pos	_	_	_	_
13	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2322
# text = These results suggest a microenvironment-directed, two-step model for GATA-1 expression in differentiating hematopoietic progenitors that involves (i) cycle-dependent initiation and (ii) lineage-dependent maintenance or suppression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	step	step	NOUN	NN	Number=Sing	_	_	_	_
12	model	model	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
21	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2323
# text = Hypothetically, on/off switches of lineage-restricted transactivators may underlie the binary fate decisions of hematopoietic progenitors.
1	Hypothetically	Hypothetically	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	off	off	ADP	IN	_	_	_	_	_
6	switches	switche	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	binary	binary	ADJ	JJ	Degree=Pos	_	_	_	_
16	fate	fate	NOUN	NN	Number=Sing	_	_	_	_
17	decisions	decision	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2324
# text = Document 003003184 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003184	003003184	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2325
# text = HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus (HIV) entry, efficient HIV replication, and progression to AIDS, Utilizing CD4 positive T cell lines and purified T cells from normal individuals, we have demonstrated that native envelope glycoproteins of HIV, gp 160, can induce activation of transcription factor, activated protein-1 (AP-1).
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
5	glycoproteins	glycoprotein	NOUN	NNS	Number=Plur	_	_	_	_
6	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
21	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	J	j	PROPN	NNP	Number=Sing	_	_	_	_
24	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
25	Chem	Chem	PROPN	NNP	Number=Sing	_	_	_	_
26	1995	1995	NUM	CD	NumType=Card	_	_	_	_
27	Dec	Dec	PROPN	NNP	Number=Sing	_	_	_	_
28	1;270	1;270	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	:29038	:29038	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
34	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
37	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
43	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
47	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
54	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
55	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
59	to	to	ADP	IN	_	_	_	_	_
60	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	Utilizing	Utilize	PROPN	NNP	Number=Sing	_	_	_	_
63	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
64	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
65	T	t	NUM	CD	NumType=Card	_	_	_	_
66	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
67	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
68	and	and	CCONJ	CC	_	_	_	_	_
69	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
70	T	t	PROPN	NNP	Number=Sing	_	_	_	_
71	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
72	from	from	ADP	IN	_	_	_	_	_
73	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
74	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
77	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
78	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
79	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
80	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
81	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
82	glycoproteins	glycoprotein	NOUN	NNS	Number=Plur	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	gp	gp	NOUN	NN	Number=Sing	_	_	_	_
87	160	160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
88	,	,	PUNCT	,	_	_	_	_	_
89	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
90	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
91	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
92	of	of	ADP	IN	_	_	_	_	_
93	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
94	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
95	,	,	PUNCT	,	_	_	_	_	_
96	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
97	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
98	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
99	1	1	NUM	CD	NumType=Card	_	_	_	_
100	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
101	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
102	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
103	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
104	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
105	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2326
# text = The stimulatory effects of gp160 are mediated through the CD4 molecule, since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	gp160	gp160	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
11	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	ADP	IN	_	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
19	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	IgG	IgG	PRON	NN	Number=Sing	_	_	_	_
22	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
32	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	gp160	gp160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2327
# text = Immunoprecipitation of the gp 160-induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins.
1	Immunoprecipitation	Immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	gp	gp	NOUN	NN	Number=Sing	_	_	_	_
5	160	160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
17	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	comprised	comprise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	members	member	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2328
# text = The gp160-induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gp160	gp160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	synthesis	synthesis	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2329
# text = This stimulation can also be abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blocker or cyclosporine A.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	unaffected	unaffect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	channel	channel	NOUN	NN	Number=Sing	_	_	_	_
21	blocker	blocker	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	_
24	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2330
# text = This gp160 treatment adversely affects the functional capabilities of T cells: pre-treatment of CD4+
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	adversely	adversely	ADV	RB	_	_	_	_	_
5	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	capabilities	capability	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	pre-treatment	pre-treatment	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_

# sent_id = 2331
# text = T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3-induced interleukin-2 secretion.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	h	h	NOUN	NN	Number=Sing	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	37	37	NUM	CD	NumType=Card	_	_	_	_
10	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
11	C	class	PROPN	NNP	Number=Sing	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2332
# text = Effects similar to gp160 were seen with anti-CD4 mAb.
1	Effects	Effect	PROPN	NNPS	Number=Plur	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	anti-CD4	anti-CD4	NUM	CD	NumType=Card	_	_	_	_
9	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2333
# text = The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites, e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
23	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	e.g.	e.g.	X	FW	_	_	_	_	_
30	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
35	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
36	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	concurrently	concurrently	ADV	RB	_	_	_	_	_
43	lead	lead	ADV	RB	_	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
47	unresponsiveness	unresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
48	by	by	SCONJ	IN	_	_	_	_	_
49	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
50	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	2	2	NUM	CD	NumType=Card	_	_	_	_
53	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2334
# text = Document 003003190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003190	003003190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2335
# text = [The role of glucocorticoid receptors and HLA antigens in the pathogenesis of Cushing's syndrome] Lymphocytic levels of glucocorticoid receptors were evaluated in 114 patients suffering from Icenko-Cushing's syndrome.
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	HLA	Hla	ADJ	JJ	Degree=Pos	_	_	_	_
9	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	's	's	PART	POS	_	_	_	_	_
16	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
18	Lymphocytic	Lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	114	114	NUM	CD	NumType=Card	_	_	_	_
27	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
28	suffering	suffer	VERB	VBG	VerbForm=Ger	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	Icenko	Icenko	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	's	's	PART	POS	_	_	_	_	_
34	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2336
# text = Incidence of HLA antigens was determined in 94 of them.
1	Incidence	Incidence	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HLA	Hla	PROPN	NNP	Number=Sing	_	_	_	_
4	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	94	94	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2337
# text = A significant rise of A10 and B27 antigen incidence compared to that in normal subjects allows these antigens to be considered genetic markers of Icenko-Cushing's syndrome.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	A10	A10	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	B27	B27	NUM	CD	NumType=Card	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	incidence	incidence	NOUN	NN	Number=Sing	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
16	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
23	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Icenko	Icenko	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	's	's	PART	POS	_	_	_	_	_
29	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2338
# text = The levels of glucocorticoid receptors in lymphocytes of the patients are lower than in normal subjects both in the active stage of the disease and following bilateral total adrenalectomy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
13	than	than	ADP	IN	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
27	bilateral	bilateral	ADJ	JJ	Degree=Pos	_	_	_	_
28	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
29	adrenalectomy	adrenalectomy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2339
# text = The patients carrying B27 antigen had lymphocytic receptor concentrations under the levels of such in patients free of the antigen carriage.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
4	B27	B27	NUM	CD	NumType=Card	_	_	_	_
5	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
6	had	have	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	under	under	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
21	carriage	carriage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2340
# text = Antigen B27 seems to be a cause of lower levels of glucocorticoid receptors in blood lymphocytes.
1	Antigen	Antigen	ADJ	JJ	Degree=Pos	_	_	_	_
2	B27	B27	NOUN	NN	Number=Sing	_	_	_	_
3	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	lower	lower	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2341
# text = Document 003003197 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003197	003003197	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2342
# text = Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	's	's	PART	POS	_	_	_	_	_
7	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
8	derives	derive	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	post	post	X	AFX	_	_	_	_	SpaceAfter=No
11	-germinal	-germinal	ADJ	JJ	Degree=Pos	_	_	_	_
12	center	center	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2343
# text = Human immunodeficiency virus-associated Hodgkin's disease (HIV-HD) displays several peculiarities when compared with HD of the general population.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus-associated	virus-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	's	's	PART	POS	_	_	_	_	_
6	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	HD	hd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	peculiarities	peculiarity	NOUN	NNS	Number=Plur	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	HD	hd	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
22	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2344
# text = These include overrepresentation of clinically aggressive histologic types and frequent infection of Reed-Sternberg (RS) cells by Epstein-Barr virus (EBV).
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	overrepresentation	overrepresentation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	clinically	clinically	ADV	RB	_	_	_	_	_
6	aggressive	aggressive	ADJ	JJ	Degree=Pos	_	_	_	_
7	histologic	histologic	NOUN	NN	Number=Sing	_	_	_	_
8	types	type	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	frequent	frequent	ADJ	JJ	Degree=Pos	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Reed	ree	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Sternberg	Sternberg	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RS	rs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2345
# text = Recently, we have reported that the histogenesis of HD of the general population may be assessed by monitoring the expression pattern of BCL-6, a transcription factor expressed in germinal center (GC) B cells, and of CD138/syndecan-1 (syn-1), a proteoglycan associated with post-GC, terminal B-cell differentiation.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	histogenesis	histogenesis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HD	hd	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
14	population	population	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	monitoring	monitor	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
34	center	center	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	CD138/syndecan	CD138/syndecan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	syn	syn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	proteoglycan	proteoglycan	ADJ	JJ	Degree=Pos	_	_	_	_
54	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	with	with	ADP	IN	_	_	_	_	_
56	post	post	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-GC	-gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
60	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
63	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2346
# text = In this study, we have applied these two markers to the study of HIV-HD histogenesis and correlated their expression status to the virologic features of this disease.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	study	study	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	HD	HD	NOUN	NN	Number=Sing	_	_	_	_
18	histogenesis	histogenesis	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	status	status	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	virologic	virologic	NOUN	NN	Number=Sing	_	_	_	_
27	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2347
# text = We have found that RS cells of all histologic categories of HIV-HD consistently display the BCL-6(-)/syn-1(+) phenotype and thus reflect post-GC B cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	RS	rs	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	histologic	histologic	ADJ	JJ	Degree=Pos	_	_	_	_
10	categories	category	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	HD	HD	PROPN	NNP	Number=Sing	_	_	_	_
15	consistently	consistently	ADV	RB	_	_	_	_	_
16	display	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
23	/syn	/syn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	+)	+)	SYM	NFP	_	_	_	_	_
27	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	thus	thus	ADV	RB	_	_	_	_	_
30	reflect	reflect	VERB	VB	VerbForm=Inf	_	_	_	_
31	post	post	X	AFX	_	_	_	_	SpaceAfter=No
32	-GC	-gc	ADJ	JJ	Degree=Pos	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2348
# text = Although BCL-6(-)/syn-1(+)RS cells of HIV-HD express CD40, they are not surrounded by CD40 ligand-positive (CD40L+) reactive T lymphocytes, which, in HD of the general population, are thought to regulate the disease phenotype through CD40/CD40L interactions.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-6(	-6(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
5	/syn	/syn	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
6	-1(+)	-1(+)	SYM	NFP	_	_	_	_	SpaceAfter=No
7	RS	R	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	HD	HD	NOUN	NN	Number=Sing	_	_	_	_
13	express	express	NOUN	NN	Number=Sing	_	_	_	_
14	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	surrounded	surround	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
22	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	NOUN	NN	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	HD	hd	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
40	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
43	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	to	to	PART	TO	_	_	_	_	_
45	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
48	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
49	through	through	ADP	IN	_	_	_	_	_
50	CD40/CD40L	Cd40/cd40l	NOUN	NN	Number=Sing	_	_	_	_
51	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2349
# text = Conversely, RS cells of virtually all HIV-HD express the EBV-encoded latent membrane protein 1 (LMP1), which, being functionally homologous to CD40, may contribute, at least in part, to the modulation of the HIV-HD phenotype.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	RS	rs	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	virtually	virtually	ADV	RB	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	HD	HD	NOUN	NN	Number=Sing	_	_	_	_
11	express	express	NOUN	NN	Number=Sing	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
27	functionally	functionally	ADV	RB	_	_	_	_	_
28	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	at	at	ADV	RB	_	_	_	_	_
36	least	least	ADV	RBS	Degree=Sup	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	HD	hd	NOUN	NN	Number=Sing	_	_	_	_
48	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2350
# text = Document 003003202 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003202	003003202	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2351
# text = Inhibition of nuclear factor kappa
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2352
# text = B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
3	p65	p65	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
16	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2353
# text = Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1.
1	Lipopolysaccharide	Lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	most	most	ADV	RBS	_	_	_	_	_
7	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
8	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
9	substances	substance	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
14	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
15	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2354
# text = The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	still	still	ADV	RB	_	_	_	_	_
16	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2355
# text = Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50	p50	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
32	when	when	ADV	WRB	PronType=Int	_	_	_	_
33	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2356
# text = Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation, and a new mechanism of drug action was suggested recently.
1	Nonsteroidal	Nonsteroidal	ADJ	JJ	Degree=Pos	_	_	_	_
2	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	salicylates	salicylate	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	treat	treat	VERB	VB	VerbForm=Inf	_	_	_	_
12	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
22	action	action	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2357
# text = Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
1	Salicylates	Salicylate	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
30	"	"	PUNCT	''	_	_	_	_	SpaceAfter=No
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	"	"	PUNCT	''	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
43	B	b	PROPN	NNP	Number=Sing	_	_	_	_
44	into	into	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
47	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2358
# text = However, the nature of the subunit involved in this mechanism has not been defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2359
# text = To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	salicylates	salicylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	affect	affect	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	_
28	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	Porphyromonas	Porphyromonas	PROPN	NNP	Number=Sing	_	_	_	_
32	gingivalis	gingivalis	PROPN	NNP	Number=Sing	_	_	_	_
33	lipopolysaccharide-stimulated	lipopolysaccharide-stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2360
# text = High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
5	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
6	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	p65	p65	NUM	CD	NumType=Card	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
20	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	p50	p50	NUM	CD	NumType=Card	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
28	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
29	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	no	no	DET	DT	_	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2361
# text = The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	salicylate	salicylate	ADJ	JJ	Degree=Pos	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	highlight	highlight	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	control	control	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2362
# text = Document 003003205 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003205	003003205	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2363
# text = ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma.
1	ICSAT	Icsat	NOUN	NN	Number=Sing	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
8	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
14	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2364
# text = ICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library.
1	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	_
4	Consensus	consensus	PROPN	NNP	Number=Sing	_	_	_	_
5	Sequence	Sequence	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	Activated	activate	PROPN	NNP	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	member	member	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
22	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	originally	originally	ADV	RB	_	_	_	_	_
33	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	through	through	ADP	IN	_	_	_	_	_
35	Southwestern	southwestern	ADJ	JJ	Degree=Pos	_	_	_	_
36	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	Adult	adult	PROPN	NNP	Number=Sing	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	16T	16t	ADJ	JJ	Degree=Pos	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
49	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2365
# text = In this study, we created transgenic mice overexpressing ICSAT in lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	created	create	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
8	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
9	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
10	ICSAT	Icsat	PRON	WP	PronType=Int	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2366
# text = Although spontaneous tumorigenesis was not observed, IL-2 production with Concanavalin A stimulation was significantly increased in transgenic mice overexpressing ICSAT.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
3	tumorigenesis	tumorigenesis	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	Concanavalin	Concanavalin	PROPN	NNP	Number=Sing	_	_	_	_
14	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
21	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
22	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
23	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2367
# text = ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 production.
1	ICSAT	Icsit	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	leukemogenesis	leukemogenesis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
14	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	MM	mm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	leukemogenesis	leukemogenesis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	via	via	NOUN	NN	Number=Sing	_	_	_	_
35	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
36	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2368
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2369
# text = Document 003003208 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003208	003003208	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2370
# text = The DNA and steroid binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	CLL	Cll	NOUN	NN	Number=Sing	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2371
# text = The aim of this study was to investigate whether mutations in the glucocorticoid receptor could account for the increasing unresponsiveness of patients with chronic lymphatic leukemia (CLL) to combination chemotherapy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
9	whether	whether	SCONJ	IN	_	_	_	_	_
10	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
20	unresponsiveness	unresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
25	lymphatic	lymphatic	ADJ	JJ	Degree=Pos	_	_	_	_
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	CLL	CLL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
32	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2372
# text = The receptor was tested immunocytochemically, in steroid binding assays, and by a mutation screening (denaturing gradient gel electrophoresis) of the receptor-cDNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	immunocytochemically	immunocytochemically	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
16	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	denaturing	denatur	VERB	VBG	VerbForm=Ger	_	_	_	_
19	gradient	gradient	ADJ	JJ	Degree=Pos	_	_	_	_
20	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
21	electrophoresis	electrophoresis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	receptor-cDNA	receptor-cDNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2373
# text = The receptor concentration, as measured by staining and steroid binding test, varied considerably but showed no clear correlation to clinical response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	test	test	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	varied	vary	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	considerably	considerably	ADV	RB	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
20	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2374
# text = Using a highly sensitive mutation screening assay of the DNA- and the steroid-binding region, none of the treated patients revealed any mutation, suggesting that the glucocorticoid receptor in the CLL patients tested is not altered in these domains.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	highly	highly	ADV	RB	_	_	_	_	_
4	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	screening	screen	NOUN	NN	Number=Sing	_	_	_	_
7	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	none	none	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
24	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	any	any	DET	DT	_	_	_	_	_
26	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	CLL	CLL	PROPN	NNP	Number=Sing	_	_	_	_
36	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
37	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	not	not	PART	RB	_	_	_	_	_
40	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2375
# text = In one individual who had not been treated before analysis a silent mutation was found in one receptor allele.
1	In	in	ADP	IN	_	_	_	_	_
2	one	one	NUM	CD	NumType=Card	_	_	_	_
3	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
4	who	who	PRON	WP	PronType=Rel	_	_	_	_
5	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	before	before	ADP	IN	_	_	_	_	_
10	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
13	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2376
# text = The results suggest that mechanisms other than altered ligand or DNA binding of the receptor may be responsible for the lack of response to chemotherapy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	than	than	ADP	IN	_	_	_	_	_
8	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2377
# text = This conclusion is discussed in relation to the mechanism of corticoid resistance in mouse and human lymphoma cells in culture.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	corticoid	corticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2378
# text = Document 003003211 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003211	003003211	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2379
# text = Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2.
1	Block	block	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	AML1/	Aml1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MTG8	MTG8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	highly	highly	ADV	RB	_	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2380
# text = The chimeric gene, AML1/ETO (MTG8), generated in t(8;21) acute myeloid leukemia enhances the expression of Bcl-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	AML1/	Aml1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
6	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MTG8	MTG8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	8;21	8;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
18	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
19	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
20	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2381
# text = To evaluate whether this enhancement is the primary role of AML1/ETO in leukemogenesis, effects of over-expression of Bcl-2 in the murine myeloid precursor cell line, 32Dcl3, were examined.
1	To	to	PART	TO	_	_	_	_	_
2	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	AML1/	Aml1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
12	ETO	Eto	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	leukemogenesis	leukemogenesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	over-expression	over-expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
26	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
27	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	32Dcl3	32Dcl3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2382
# text = When 32Dcl3 cells expressing exogenous Bcl-2 were induced to differentiate, the onset of morphological differentiation was delayed.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
6	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2383
# text = However, even the cells expressing very high levels of exogenous Bcl-2 eventually underwent differentiation without a significant decrease in the synthesis of Bcl-2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	even	even	ADV	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-2	-2	NUM	CD	NumType=Card	_	_	_	_
14	eventually	eventually	ADV	RB	_	_	_	_	_
15	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	without	without	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
20	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2384
# text = On the contrary, 32Dcl3 cells stably expressing AML1/ETO were completely resistant to differentiation and continued to grow in the presence of G-CSF.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	stably	stably	ADV	RB	_	_	_	_	_
9	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
10	AML1/	AML1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
11	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	continued	continue	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	grow	grow	VERB	VB	VerbForm=Inf	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2385
# text = These results are consistent with the interpretation that stimulation of Bcl-2 expression is not the primary target of AML1/ETO.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	interpretation	interpretation	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	target	target	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2386
# text = Document 003003214 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003214	003003214	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2387
# text = Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.
1	Cloning	Cloning	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
4	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
18	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	ADP	IN	_	_	_	_	_
29	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2388
# text = CD3-epsilon gene expression is confined to the T cell lineage.
1	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-epsilon	-epsilon	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2389
# text = We have recently identified and cloned a human transcription factor, TCF-1, that binds to a functional element in the T lymphocyte-specific enhancer of CD3-epsilon.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2390
# text = In a panel of human cell lines, TCF-1 expression was restricted to T lineage cells.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2391
# text = TCF-1 belonged to a novel family of genes that contain the so-called high mobility group 1 (HMG) box.
1	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	belonged	belong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
18	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
19	group	group	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HMG	HMG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2392
# text = Here we report the cloning of murine TCF-1.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
8	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2393
# text = Two splice alternatives were identified that were not previously observed in human TCF-1.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	splice	splice	NOUN	NN	Number=Sing	_	_	_	_
3	alternatives	alternative	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	previously	previously	ADV	RB	_	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2394
# text = Murine and human TCF-1 displayed a 95.5% overall amino acid homology.
1	Murine	Murine	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	95.5	95.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
12	amino	amino	DET	DT	_	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	homology	homology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2395
# text = Recombinant murine and human TCF-1 recognized the same sequence motif in the CD3-epsilon enhancer as judged by gel retardation and methylation interference assays.
1	Recombinant	Recombinant	NOUN	NN	Number=Sing	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	recognized	recognize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
23	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	_
26	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2396
# text = With the murine cDNA clones several aspects of TCF-1 were analyzed.
1	With	with	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
6	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
7	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2397
# text = First, deletion analysis revealed that a region of TCF-1 containing the HMG box was sufficient for sequence-specific binding.
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
16	box	box	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2398
# text = Second, by high stringency Northern blotting and in situ hybridization, TCF-1 expression was shown to be confined to the thymus and to the T cell areas of the spleen.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	stringency	stringency	NOUN	NN	Number=Sing	_	_	_	_
6	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
7	blotting	blott	VERB	VBG	VerbForm=Ger	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
11	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	areas	area	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2399
# text = Third, TCF-1 bound specifically to a functional T cell-specific element in the T cell receptor alpha (TCR-alpha) enhancer.
1	Third	third	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	bound	bound	NOUN	NN	Number=Sing	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2400
# text = The T lineage-specific expression and the affinity for functional motifs in the TCR-alpha and CD3-epsilon enhancers imply an important role for TCF-1 in the establishment of the mature T cell phenotype.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
22	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
23	imply	imply	ADV	RB	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	establishment	establishment	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2401
# text = Document 003003216 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003216	003003216	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2402
# text = Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	BK	BK	PROPN	NNP	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2403
# text = The production and characterization of Jurkat cell lines that constitutively express functional human immune deficiency virus type 1 (HIV-1) tat protein, using a BK virus plasmid expression vector and HIV-1 tat cDNA, is described.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	constitutively	constitutively	ADV	RB	_	_	_	_	_
11	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	immune	immune	NOUN	NN	Number=Sing	_	_	_	_
15	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	BK	BK	PROPN	NNP	Number=Sing	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
39	cDNA	cDNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2404
# text = An increased growth rate of these Jurkat-tat cell lines as compared with control cell lines was observed.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2405
# text = Document 003003220 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003220	003003220	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2406
# text = RB and a novel E2F-1 binding protein in MHC class II deficient B-cell lines and normal IFN-gamma induction of the class IL transactivator CIITA in class II non-inducible RB-defective tumor lines.
1	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	class	class	NOUN	NN	Number=Sing	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	_
29	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
30	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	class	class	NOUN	NN	Number=Sing	_	_	_	_
33	II	ii	NUM	CD	NumType=Card	_	_	_	_
34	non-inducible	non-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
35	RB	Rb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
38	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2407
# text = The major histocompatibility (MHC) class II genes encode cell surface proteins that bind antigenic peptide for presentation to T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	presentation	presentation	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2408
# text = The class II proteins are expressed constitutively on B-cells and EBV-transformed B-cells, and are inducible by IFN-gamma on a wide variety of cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	EBV	haEbve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
30	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2409
# text = Retinoblastoma protein (RB) is a tumor suppressor and functions as a transcriptional repressor by binding and inactivating the transactivator E2F-I.
1	Retinoblastoma	Retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RB	RB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	inactivating	inactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
22	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	I.	I.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2410
# text = RB-defective tumor lines are non-inducible for MHC class II by IFN-gamma, or very weakly inducible, but transfection of 2 different lines with RB expression vectors re-establishes or substantially enhances class II inducibility.
1	RB	Rb	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	non-inducible	non-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	very	very	ADV	RB	_	_	_	_	_
19	weakly	weakly	ADV	RB	_	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
32	re	re	ADP	IN	_	_	_	_	SpaceAfter=No
33	-establishes	-establish	NOUN	NNS	Number=Plur	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	substantially	substantially	ADV	RB	_	_	_	_	_
36	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	class	class	NOUN	NN	Number=Sing	_	_	_	_
38	II	ii	NUM	CD	NumType=Card	_	_	_	_
39	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2411
# text = Therefore, we examined the RB status of a series of B-cell mutants that are defective in class II expression, generated either in vitro or derived from Bare Lymphocyte Syndrome (BLS) patients.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
7	status	status	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	series	series	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	either	either	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	Bare	bare	PROPN	NNP	Number=Sing	_	_	_	_
32	Lymphocyte	Lymphocyte	PROPN	NNP	Number=Sing	_	_	_	_
33	Syndrome	Syndrome	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	BLS	BLS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2412
# text = Nuclear matrix-bound RB was detectable in all cases, indicating that loss of RB is not responsible for decreased class II expression in these lines.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
5	RB	Rb	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2413
# text = A second E2F-I binding protein, most likely DP-I, was also apparently normal in both class II-positive and -negative B-cell lines.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	protein	protein	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
10	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
11	DP	Dp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	apparently	apparently	ADV	RB	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	class	class	NOUN	NN	Number=Sing	_	_	_	_
22	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2414
# text = We also examined the IFN-gamma induction of CIITA in RB-defective lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	RB	RB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2415
# text = CIITA is a class II gene transactivator known to be defective in one form of BLS and to be required for the induction of MHC class II by IFN-gamma.
1	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
8	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	form	form	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	BLS	BLS	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
26	class	class	NOUN	NN	Number=Sing	_	_	_	_
27	II	ii	NUM	CD	NumType=Card	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2416
# text = CIITA mRNA is normally inducible by IFN-gamma in class II non-inducible, RB-defective lines, and in one line, re-expression of RB has no effect on CIITA mRNA induction levels.
1	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	normally	normally	ADV	RB	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	class	class	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	non-inducible	non-inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	RB	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	re-expression	re-expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
28	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	no	no	DET	DT	_	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	CIITA	CIITa	PROPN	NNP	Number=Sing	_	_	_	_
33	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2417
# text = Thus, the block in MHC class II inducibility in RB-defective cells is not due to a block in CIITA inducibility.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	block	block	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	RB	RB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	due	due	ADP	IN	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	block	block	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
23	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2418
# text = Document 003003224 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003224	003003224	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2419
# text = The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rhombotin	rhombotin	ADJ	JJ	Degree=Pos	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
8	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
11	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	members	member	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
24	11p15	11p15	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	11p13	11p13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2420
# text = A chromosomal translocation in a T-cell leukemia involving the short arm of human chromosome 11 at band 11p15 disrupts the rhombotin gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
9	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
12	arm	arm	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
16	11	11	NUM	CD	NumType=Card	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	band	band	NOUN	NN	Number=Sing	_	_	_	_
19	11p15	11p15	NUM	CD	NumType=Card	_	_	_	_
20	disrupts	disrupt	NOUN	NNS	Number=Plur	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	rhombotin	rhombotin	ADJ	JJ	Degree=Pos	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2421
# text = This gene encodes a protein with duplicated cysteine-rich regions called LIM domains, which show homology to zinc-binding proteins and to iron-sulfur centers of ferredoxins.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	duplicated	duplicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
11	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
12	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	_
14	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	iron	iron	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	sulfur	sulfur	NOUN	NN	Number=Sing	_	_	_	_
29	centers	center	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	ferredoxins	ferredoxin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2422
# text = Two homologues of the rhombotin gene have now been isolated.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	homologues	homologue	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	rhombotin	rhombotin	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	now	now	ADV	RB	_	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2423
# text = One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	Rhom	rhom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
15	11	11	NUM	CD	NumType=Card	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	band	band	NOUN	NN	Number=Sing	_	_	_	_
18	11p13	11p13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	where	where	ADV	WRB	PronType=Rel	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
30	occur	occur	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	all	all	DET	DT	_	_	_	_	_
33	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
34	breakpoints	breakpoint	NOUN	NNS	Number=Plur	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	11p13	11p13	NUM	CD	NumType=Card	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	Rhom	rhom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2424
# text = Human and mouse Rhom-2 are highly conserved and, like rhombotin, encode two tandem cysteine-rich LIM domains.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	Rhom	rhom	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	highly	highly	ADV	RB	_	_	_	_	_
9	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	like	like	ADP	IN	_	_	_	_	_
13	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
18	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
21	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2425
# text = Rhom-2 mRNA is expressed in early mouse development in central nervous system, lung, kidney, liver, and spleen but only very low levels occur in thymus.
1	Rhom	Rhom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
13	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
14	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	liver	liver	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	only	only	ADV	RB	_	_	_	_	_
26	very	very	ADV	RB	_	_	_	_	_
27	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2426
# text = The other gene, designated Rhom-3, is not on chromosome 11 but also retains homology to the LIM domain of rhombotin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	Rhom	rhom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
14	11	11	NUM	CD	NumType=Card	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	retains	retain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	LIM	LIM	PROPN	NNP	Number=Sing	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2427
# text = Since the Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors, the consistency of translocations near the rhombotin gene was further examined.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	Rhom	rhom	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	such	such	DET	PDT	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
14	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	consistency	consistency	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
24	near	near	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	further	further	ADV	RB	_	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2428
# text = A second translocation adjacent to rhombotin was found and at the same position as in the previous example.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	adjacent	adjacent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	rhombotin	rhombotin	VERB	VB	VerbForm=Inf	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
13	position	position	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
18	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2429
# text = Therefore, chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	chromosome	chromosome	DET	DT	_	_	_	_	_
4	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
5	11p15	11p15	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	11p13	11p13	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Rhom	rhom	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	chromosome	chromosome	DET	DT	_	_	_	_	_
21	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	11p15	11p15	NUM	CD	NumType=Card	_	_	_	_
30	target	target	NOUN	NN	Number=Sing	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	rarely	rarely	ADV	RB	_	_	_	_	_
33	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2430
# text = The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	duplicated	duplicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
20	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	_
21	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2431
# text = Document 003003225 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003225	003003225	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2432
# text = Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.
1	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	death	death	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	localization	localization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2433
# text = We searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	searched	search	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	interleukin	interleukin	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	deprived	deprive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
33	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2434
# text = The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	co-immunoprecipitation	co-immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2435
# text = Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras.
1	Indirect	Indirect	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Aiolos	Aiolo	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
17	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2436
# text = We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	Aiolos	Aiolo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2437
# text = Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
23	control	control	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2438
# text = Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells.
1	Co	co	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	confirm	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
8	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
15	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	deprived	deprive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2439
# text = We propose a model for the regulation of Bcl-2 expression via Aiolos.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2440
# text = Document 003003226 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003226	003003226	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2441
# text = Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	promote	promote	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	nonphlogistic	nonphlogistic	ADJ	JJ	Degree=Pos	_	_	_	_
4	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
7	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2442
# text = Phagocyte recognition, uptake, and nonphlogistic degradation of neutrophils and other leukocytes undergoing apoptosis promote the resolution of inflammation.
1	Phagocyte	Phagocyte	NOUN	NN	Number=Sing	_	_	_	_
2	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	nonphlogistic	nonphlogistic	ADJ	JJ	Degree=Pos	_	_	_	_
8	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
15	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2443
# text = This study assessed the effects of anti-inflammatory glucocorticoids on this leukocyte clearance mechanism.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	assessed	assess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
12	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2444
# text = Pretreatment of "semimature" 5-day human monocyte-derived macrophages (M phi) for 24 h with methylprednisolone, dexamethasone, and hydrocortisone, but not the nonglucocorticoid steroids aldosterone, estradiol, and progesterone, potentiated phagocytosis of apoptotic neutrophils.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
4	semimature	semimature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	"	"	PUNCT	''	_	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	day	day	NOUN	NN	Number=Sing	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	M	m	NOUN	NN	Number=Sing	_	_	_	_
16	phi	phi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	_
20	h	h	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	methylprednisolone	methylprednisolone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	hydrocortisone	hydrocortisone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	ADV	RB	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	nonglucocorticoid	nonglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
33	steroids	steroid	NOUN	NNS	Number=Plur	_	_	_	_
34	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
45	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2445
# text = These effects were specific in that the potentiated phagocytosis of apoptotic neutrophils was completely blocked by the glucocorticoid receptor antagonist RU38486, and glucocorticoids did not promote 5-day M phi ingestion of opsonized erythrocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	completely	completely	ADV	RB	_	_	_	_	_
15	blocked	blocked	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
21	RU38486	Ru38486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
28	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	day	day	NOUN	NN	Number=Sing	_	_	_	_
31	M	m	NOUN	NN	Number=Sing	_	_	_	_
32	phi	phi	NOUN	NN	Number=Sing	_	_	_	_
33	ingestion	ingestion	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	opsonized	opsonize	ADJ	JJ	Degree=Pos	_	_	_	_
36	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2446
# text = Similar glucocorticoid-mediated potentiation was observed with 5-day M phi uptake of alternative apoptotic "targets" (eosinophils and Jurkat T cells) and in uptake of apoptotic neutrophils by alternative phagocytes (human glomerular mesangial cells and murine M phi elicited into the peritoneum or derived from bone marrow).
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
4	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	day	day	NOUN	NN	Number=Sing	_	_	_	_
11	M	be	NOUN	NN	Number=Sing	_	_	_	_
12	phi	phi	NOUN	NN	Number=Sing	_	_	_	_
13	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
16	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
17	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
18	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	"	"	PUNCT	''	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
32	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
35	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	human	human	AUX	MD	VerbForm=Fin	_	_	_	_
38	glomerular	glomerular	VERB	VB	VerbForm=Inf	_	_	_	_
39	mesangial	mesangial	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
43	M	be	NOUN	NN	Number=Sing	_	_	_	_
44	phi	phi	NOUN	NN	Number=Sing	_	_	_	_
45	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	into	into	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	peritoneum	peritoneum	NOUN	NN	Number=Sing	_	_	_	_
49	or	or	CCONJ	CC	_	_	_	_	_
50	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	from	from	ADP	IN	_	_	_	_	_
52	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
53	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2447
# text = Importantly, methylprednisolone-mediated enhancement of the uptake of apoptotic neutrophils did not trigger the release of the chemokines IL-8 and monocyte chemoattractant protein-1.
1	Importantly	importantly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	methylprednisolone	methylprednisolone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	release	release	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	8	8	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
26	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2448
# text = Furthermore, longer-term potentiation by methylprednisolone was observed in maturing human monocyte-derived M phi, with greater increases in 5-day M phi uptake of apoptotic cells being observed the earlier glucocorticoids were added during monocyte maturation into M phi.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	longer	longer	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	term	term	NOUN	NN	Number=Sing	_	_	_	_
6	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	methylprednisolone	methylprednisolone	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	maturing	mature	VERB	VBG	VerbForm=Ger	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	M	m	NOUN	NN	Number=Sing	_	_	_	_
18	phi	phi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
22	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	day	day	NOUN	NN	Number=Sing	_	_	_	_
27	M	m	NOUN	NN	Number=Sing	_	_	_	_
28	phi	phi	NOUN	NN	Number=Sing	_	_	_	_
29	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
34	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
37	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	during	during	ADP	IN	_	_	_	_	_
41	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
42	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
43	into	into	ADP	IN	_	_	_	_	_
44	M	m	NOUN	NN	Number=Sing	_	_	_	_
45	phi	phi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2449
# text = We conclude that potentiation of nonphlogistic clearance of apoptotic leukocytes by phagocytes is a hitherto unrecognized property of glucocorticoids that has potential implications for therapies aimed at promoting the resolution of inflammatory diseases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nonphlogistic	nonphlogistic	ADJ	JJ	Degree=Pos	_	_	_	_
7	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	hitherto	hitherto	NOUN	NN	Number=Sing	_	_	_	_
16	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
17	property	property	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
23	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	therapies	therapie	NOUN	NNS	Number=Plur	_	_	_	_
26	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	SCONJ	IN	_	_	_	_	_
28	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2450
# text = Document 003003229 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003229	003003229	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2451
# text = Tumor necrosis factor receptor expression and signal transduction in HIV-1-infected cells.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2452
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2453
# text = To examine the inter-relationship between HIV-1 infection and the cell surface receptors for tumor necrosis factor (TNF)-alpha, an immunoregulatory cytokine that can enhance HIV-1 replication.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inter-relationship	inter-relationship	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
17	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2454
# text = DESIGN: Infected promyelocytic and promonocytic cells were examined because they normally express both types of TNF receptors.
1	DESIGN	Design	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	because	because	SCONJ	IN	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	normally	normally	ADV	RB	_	_	_	_	_
13	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	types	type	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2455
# text = METHODS: TNF receptor surface expression was determined by specific monoclonal antibody recognition and flow cytometry, and signal transduction was detected by gel shift analysis.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	TNF	Tnf	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
13	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
16	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
20	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2456
# text = HIV-1 activation and expression was quantitated by reverse transcriptase assay.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	quantitated	quantitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
11	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2457
# text = RESULTS: In the OM-10.1 promyelocytic model of chronic infection, TNF-alpha-induced HIV-1 expression also resulted in a substantial increase in 75 kd TNF receptor (TR75) expression although 55 kD TNF receptor (TR55) levels were not dramatically altered.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	OM	Om	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
8	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	model	model	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
28	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	75	75	NUM	CD	NumType=Card	_	_	_	_
31	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
32	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	TR75	TR75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	although	although	SCONJ	IN	_	_	_	_	_
39	55	55	NUM	CD	NumType=Card	_	_	_	_
40	kD	kD	PROPN	NNP	Number=Sing	_	_	_	_
41	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	TR55	TR55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
47	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	dramatically	dramatically	ADV	RB	_	_	_	_	_
50	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2458
# text = A series of uninfected parental HL-60 subclones all reduced TR75 surface expression in response to TNF-alpha treatment.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	series	series	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
5	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
6	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	60	60	NUM	CD	NumType=Card	_	_	_	_
9	subclones	subclone	NOUN	NNS	Number=Plur	_	_	_	_
10	all	all	ADV	RB	_	_	_	_	_
11	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	TR75	TR75	NUM	CD	NumType=Card	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2459
# text = Enhanced TR75 expression on OM-10.1 cells followed the same TNF-alpha-dose dependency as that observed for HIV-1 production.
1	Enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	TR75	TR75	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	OM	OM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	followed	follow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
17	dependency	dependency	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2460
# text = An increase in TR75 expression was also evident during the peak of an acute HIV-1 infection of HL-60 promyelocytes.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	TR75	TR75	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	60	60	NUM	CD	NumType=Card	_	_	_	_
23	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2461
# text = Although TR55 expression was unaltered during TNF-alpha-induced HIV activation, this receptor was still involved in the viral activation process.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	TR55	TR55	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	unaltered	unaltered	ADJ	JJ	Degree=Pos	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	still	still	ADV	RB	_	_	_	_	_
19	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2462
# text = Antibody cross-linking of TR55, in the absence of exogenous TNF-alpha, induced maximal HIV-1 expression, an up-modulation of surface TR75, and nuclear NF-kappa B activity in OM-10.1 cultures.
1	Antibody	Antibody	NOUN	NN	Number=Sing	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-linking	VERB	VBG	VerbForm=Ger	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TR55	TR55	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
12	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
29	TR75	TR75	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	OM	OM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
42	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2463
# text = Surprisingly, this was the case even when an antagonistic anti-TR55 antibody was used.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	case	case	NOUN	NN	Number=Sing	_	_	_	_
7	even	even	ADV	RB	_	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
11	anti-TR55	anti-tr55	NOUN	NN	Number=Sing	_	_	_	_
12	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2464
# text = Anti-TR55 antibody cross-linking in chronically infected U1 promonocytic cultures could only partially substitute for TNF-alpha-induced HIV-1 expression.
1	Anti	anti	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-TR55	-TR55	NUM	CD	NumType=Card	_	_	_	_
3	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
4	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
6	in	in	ADV	RB	_	_	_	_	_
7	chronically	chronically	ADV	RB	_	_	_	_	_
8	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	U1	U1	NUM	CD	NumType=Card	_	_	_	_
10	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	partially	partially	ADV	RB	_	_	_	_	_
15	substitute	substitute	ADV	RB	_	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2465
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2466
# text = Our results demonstrated that HIV-1 infection can selectively influence the surface expression of TNF receptors, potentially influencing its own expression and altering normal immunoregulatory signal transduction.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	potentially	potentially	ADV	RB	_	_	_	_	_
20	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2467
# text = Document 003003231 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003231	003003231	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2468
# text = A chimeric type II/type I interleukin-1 receptor can mediate interleukin-1 induction of gene expression in T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	_
4	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2469
# text = The type I interleukin-1 receptor (IL-1R) is capable of transducing a signal resulting in promoter activation in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1R	1r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	SCONJ	IN	_	_	_	_	_
16	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2470
# text = This signal transduction is dependent on the cytoplasmic domain, which consists of 213 amino acids.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	213	213	NUM	CD	NumType=Card	_	_	_	_
15	amino	amino	DET	DT	_	_	_	_	_
16	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2471
# text = In contrast to the type I receptor, the type II IL-1R has a small cytoplasmic tail, and it is not clear whether this receptor is a signal-transducing or a regulatory molecule.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1R	1R	PROPN	NNP	Number=Sing	_	_	_	_
15	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
19	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
26	whether	whether	SCONJ	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	transducing	transducing	NOUN	NN	Number=Sing	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2472
# text = Here we report that the type II IL-1R does not mediate gene activation in Jurkat cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1R	1r	NOUN	NN	Number=Sing	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2473
# text = However, a hybrid receptor composed of the extracellular and transmembrane regions of the human type II interleukin-1 fused to the cytoplasmic domain of the human type I IL-1R was capable of transducing a signal across the membrane resulting in a pattern of gene activation identical to that mediated by the type I IL-1R.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	transmembrane	transmembrane	ADJ	JJ	Degree=Pos	_	_	_	_
12	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	II	ii	NUM	CD	NumType=Card	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
25	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	type	type	NOUN	NN	Number=Sing	_	_	_	_
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-1R	-1R	PROPN	NNP	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
35	of	of	SCONJ	IN	_	_	_	_	_
36	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
39	across	across	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
42	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
49	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
52	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	by	by	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	type	type	NOUN	NN	Number=Sing	_	_	_	_
56	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
57	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1R	1R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2474
# text = Our results indicated that the extracellular domain of the type II IL-1R was capable of functionally interacting with interleukin-1 and transmitting the resulting signal to a heterologous cytoplasmic domain.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	R	r	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
18	of	of	SCONJ	IN	_	_	_	_	_
19	functionally	functionally	ADV	RB	_	_	_	_	_
20	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	transmitting	transmitt	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
33	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
34	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2475
# text = Document 003003234 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003234	003003234	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2476
# text = Evidence for normal vitamin D receptor messenger ribonucleic acid and genotype in absorptive hypercalciuria.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
5	D	would	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	messenger	messenger	ADV	RBR	_	_	_	_	_
8	ribonucleic	ribonucleic	ADJ	JJ	Degree=Pos	_	_	_	_
9	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	absorptive	absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
14	hypercalciuria	hypercalciurion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2477
# text = Absorptive hypercalciuria (a stone-forming condition) is characterized by gut hyperabsorption of calcium, hypercalciuria, and reduced bone density.
1	Absorptive	Absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
2	hypercalciuria	hypercalciuria	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	stone	stone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
8	condition	condition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
14	hyperabsorption	hyperabsorption	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	hypercalciuria	hypercalciuria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
23	density	density	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2478
# text = Inasmuch as these features implicate enhanced calcitriol action in gut and bone, we analyzed the vitamin D receptor (VDR) gene to ascertain whether an abnormality of this gene marks patients with intestinal hyperabsorption of calcium.
1	Inasmuch	Inasmuch	ADV	RB	_	_	_	_	_
2	as	as	SCONJ	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
5	implicate	implicate	VERB	VB	VerbForm=Inf	_	_	_	_
6	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	calcitriol	calcitriol	NOUN	NN	Number=Sing	_	_	_	_
8	action	action	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	bone	bone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
18	D	d	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	ascertain	ascertain	VERB	VB	VerbForm=Inf	_	_	_	_
26	whether	whether	SCONJ	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	abnormality	abnormality	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	marks	mark	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
36	hyperabsorption	hyperabsorption	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2479
# text = We have compared the frequency of a restriction fragment length polymorphism (Bsm I) associated with different alleles of the VDR gene in a group of 33 well characterized absorptive hypercalciuric patients and a group of 36 normal race- and age-matched control subjects.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	restriction	restriction	NOUN	NN	Number=Sing	_	_	_	_
9	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
10	length	length	NOUN	NN	Number=Sing	_	_	_	_
11	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Bsm	Bsm	PROPN	NNP	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	33	33	NUM	CD	NumType=Card	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	absorptive	absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
32	hypercalciuric	hypercalciuric	ADJ	JJ	Degree=Pos	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	group	group	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	36	36	NUM	CD	NumType=Card	_	_	_	_
39	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
40	race	race	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	matched	match	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	control	control	NOUN	NN	Number=Sing	_	_	_	_
47	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2480
# text = There was no difference between the distribution of the VDR alleles in the patient population when compared with the normal population.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	VDR	Vdr	ADJ	JJR	Degree=Cmp	_	_	_	_
11	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
15	population	population	NOUN	NN	Number=Sing	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2481
# text = The coding region of VDR messenger RNA was also normal, as determined by both DNA sequence analysis and chemical mismatch cleavage analysis of copy DNA from 11 index absorptive hypercalciuric patients.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
6	messenger	messenger	PROPN	NNP	Number=Sing	_	_	_	_
7	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	chemical	chemical	ADJ	JJ	Degree=Pos	_	_	_	_
21	mismatch	mismatch	NOUN	NN	Number=Sing	_	_	_	_
22	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
23	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	11	11	NUM	CD	NumType=Card	_	_	_	_
29	index	index	NOUN	NN	Number=Sing	_	_	_	_
30	absorptive	absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
31	hypercalciuric	hypercalciuric	ADJ	JJ	Degree=Pos	_	_	_	_
32	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2482
# text = On the basis of these results, we propose that the enhanced intestinal calcium absorption invariably seen in absorptive hypercalciuria and attendant symptoms of this disorder are not attributable to mutations of the VDR and are not linked to a common VDR genotype.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
14	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
15	absorption	absorption	NOUN	NN	Number=Sing	_	_	_	_
16	invariably	invariably	ADV	RB	_	_	_	_	_
17	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	absorptive	absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
20	hypercalciuria	hypercalciurion	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	attendant	attendant	ADJ	JJ	Degree=Pos	_	_	_	_
23	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
42	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
43	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2483
# text = Document 003003239 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003239	003003239	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2484
# text = Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder.
1	Abnormalities	Abnormality	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
4	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
5	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
14	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2485
# text = BACKGROUND: Abnormalities in the cyclic adenosine monophosphate (cAMP)-dependent phosphorylation system have been recently reported in patients with bipolar disorder.
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Abnormalities	Abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
7	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
8	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	system	system	NOUN	NN	Number=Sing	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	recently	recently	ADV	RB	_	_	_	_	_
19	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
24	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2486
# text = We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Rap1	Rap1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
34	euthymic	euthymic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	manic	manic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	depressed	depress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
43	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
46	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2487
# text = METHODS: Platelets were collected from 112 drug-free patients with bipolar disorder (52 euthymic, 29 depressed, and 31 manic) and 62 healthy subjects.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Platelets	Platelet	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	collected	collect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	112	112	NUM	CD	NumType=Card	_	_	_	_
8	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
11	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
14	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	52	52	NUM	CD	NumType=Card	_	_	_	_
17	euthymic	euthymic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	29	29	NUM	CD	NumType=Card	_	_	_	_
20	depressed	depressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	31	31	NUM	CD	NumType=Card	_	_	_	_
24	manic	manic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	62	62	NUM	CD	NumType=Card	_	_	_	_
28	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
29	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2488
# text = The levels of cAMP-dependent protein kinase and Rap1 were assessed by Western blot analysis, immunostaining, and computer-assisted imaging.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Rap1	rap1	PROPN	NNP	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
15	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
16	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	immunostaining	immunostain	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	computer	computer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	assisted	assist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	imaging	imaging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2489
# text = RESULTS: The immunolabeling of the catalytic subunit of cAMP-dependent protein kinase was significantly different among groups (P<.001), with higher values in untreated depressed and manic patients with bipolar disorder compared with untreated euthymic patients with bipolar disorder and healthy subjects.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunolabeling	immunolabeling	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	among	among	ADP	IN	_	_	_	_	_
19	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
28	values	value	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
31	depressed	depressed	ADJ	JJ	Degree=Pos	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	manic	manic	ADJ	JJ	Degree=Pos	_	_	_	_
34	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
37	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
38	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
41	euthymic	euthymic	ADJ	JJ	Degree=Pos	_	_	_	_
42	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
45	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
48	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2490
# text = No significant differences were found in the immunolabeling of the regulatory subunits (type I and type II) of cAMP-dependent protein kinase.
1	No	no	DET	DT	_	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	immunolabeling	immunolabeling	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	type	type	INTJ	UH	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	II	ii	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2491
# text = The immunolabeling of Rap1 was significantly higher (P<.001) in untreated euthymic, depressed, and manic patients than in healthy persons.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunolabeling	immunolabeling	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Rap1	Rap1	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	significantly	significantly	ADV	RB	_	_	_	_	_
7	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
15	euthymic	euthymic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	depressed	depress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	manic	manic	ADJ	JJ	Degree=Pos	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
25	persons	person	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2492
# text = CONCLUSIONS: Levels of Rap1 and the catalytic subunit of cAMP-dependent protein kinase are altered in the platelets of bipolar patients.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Rap1	Rap1	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2493
# text = These findings may provide clues toward understanding the involvement of cAMP signaling in the pathogenesis of bipolar disorder.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
5	clues	clue	NOUN	NNS	Number=Plur	_	_	_	_
6	toward	toward	SCONJ	IN	_	_	_	_	_
7	understanding	understande	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
12	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
18	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2494
# text = Document 003003242 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003242	003003242	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2495
# text = Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	PD98059	Pd98059	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2496
# text = The purpose of this study was to evaluate whether the mitogen-activated protein kinase (MAPK) signaling pathway contributes to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mononuclear differentiation in the human myeloblastic leukemia ML-1 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
9	whether	whether	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	12-	12-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	O	o	INTJ	UH	_	_	_	_	SpaceAfter=No
25	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
26	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	myeloblastic	myeloblastic	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
40	ML	Ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2497
# text = Upon TPA treatment, the activity of ERK1 and ERK2 rapidly increased, with maximal induction between 1 and 3 h, while ERK2 protein levels remained constant.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ERK1	ERK1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	ERK2	ERK2	NUM	CD	NumType=Card	_	_	_	_
11	rapidly	rapidly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	while	while	SCONJ	IN	_	_	_	_	_
24	ERK2	ERK2	NUM	CD	NumType=Card	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2498
# text = The activity of JNK1 was also significantly induced, with JNK1 protein levels increasing moderately during exposure to TPA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	JNK1	JNK1	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	significantly	significantly	ADV	RB	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	JNK1	JNK1	PROPN	NNP	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
15	moderately	moderately	ADV	RB	_	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2499
# text = Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	ERK2	Erk2	NUM	CD	NumType=Card	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2500
# text = Furthermore, PD98059 completely blocked the TPA-induced differentiation of ML-1 cells, as assessed by a number of features associated with mononuclear differentiation including changes in morphology, nonspecific esterase activity, phagocytic ability, NADPH oxidase activity, mitochondrial respiration, and c-jun mRNA inducibility.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	_
4	completely	completely	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	number	number	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
34	esterase	esterase	NOUN	NN	Number=Sing	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	phagocytic	phagocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	ability	ability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	NADPH	NADPH	DET	DT	_	_	_	_	_
41	oxidase	oxidase	ADJ	JJ	Degree=Pos	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	mitochondrial	mitochondrial	ADJ	JJ	Degree=Pos	_	_	_	_
45	respiration	respiration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
49	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
50	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
51	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2501
# text = We conclude that activation of the MEK/ERK signaling pathway is necessary for TPA-induced mononuclear cell differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2502
# text = Document 003003247 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003247	003003247	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2503
# text = Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-induced apoptosis.
1	Estrogen	Estrogen	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	monoblastoid	monoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2504
# text = Induction of apoptosis of mononucleated cells is a physiological process for regulating the intensity of the immune response.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	mononucleated	mononucleate	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
10	process	process	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	SCONJ	IN	_	_	_	_	_
12	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2505
# text = The female steroid hormones estrogen (E2) and progesterone (Prog) are known to modulate the reactivity of the immune system; recently it has been demonstrated that they can regulate induction of apoptosis of endothelial cells and osteoblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
3	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
4	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
5	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Prog	Prog	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	;	;	PUNCT	,	_	_	_	_	_
25	recently	recently	ADV	RB	_	_	_	_	_
26	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
32	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
33	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	osteoblasts	osteoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2506
# text = TNF-alpha-mediated induction of apoptosis has been well characterized in myeloid cells.
1	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	well	well	ADV	RB	Degree=Pos	_	_	_	_
11	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2507
# text = We investigated whether E2 and Prog could interfere with TNF-alpha-induced apoptosis of the monoblastoid U937 cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	E2	E2	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Prog	Prog	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	monoblastoid	monoblastoid	NOUN	NN	Number=Sing	_	_	_	_
19	U937	U937	NUM	CD	NumType=Card	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2508
# text = Treatment with E2 or Prog increased survival and prevented apoptosis induced by TNF-alpha in both undifferentiated and macrophage-like PMA-differentiated U937 cells, as assessed by trypan blue exclusion cell counting, thymidine incorporation, AnnexinV labeling, followed by flow cytometry and DNA fragmentation studies.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	E2	E2	NUM	CD	NumType=Card	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	Prog	Prog	PROPN	NNP	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	like	like	ADP	IN	_	_	_	_	_
23	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	trypan	trypan	ADJ	JJ	Degree=Pos	_	_	_	_
33	blue	blue	ADJ	JJ	Degree=Pos	_	_	_	_
34	exclusion	exclusion	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	counting	counting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
39	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	AnnexinV	AnnexinV	PROPN	NNP	Number=Sing	_	_	_	_
42	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
47	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
50	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
51	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2509
# text = This effect can be associated with the activation of specific hormone receptors, since we observed the expression of the estrogen receptor alpha (ER-alpha), ER-beta, and progesterone receptor (PR) mRNAs; the ER-alpha protein expression was confirmed by immunocytochemical analysis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	since	since	SCONJ	IN	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	estrogen	estrogen	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	PR	pr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	;	;	PUNCT	,	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	ER-	ER-	X	AFX	_	_	_	_	SpaceAfter=No
44	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
45	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
48	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	immunocytochemical	immunocytochemical	ADJ	JJ	Degree=Pos	_	_	_	_
51	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2510
# text = In addition, hormone-mediated survival against apoptosis was concentration dependent, reaching the half-maximal effect at 10 nM and blocked by the ER antagonist ICI 182,780 in undifferentiated cells, further supporting a receptor-mediated mechanism of cell survival.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
8	against	against	ADP	IN	_	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	reaching	reach	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	10	10	NUM	CD	NumType=Card	_	_	_	_
22	nM	nm	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ER	er	NOUN	NN	Number=Sing	_	_	_	_
28	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
29	ICI	ICI	PROPN	NNP	Number=Sing	_	_	_	_
30	182,780	182,780	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	further	further	ADV	RB	_	_	_	_	_
36	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2511
# text = Other steroid receptor drugs such as Raloxifene, RU486, or the ICI 182,780 in PMA-differentiated cells displayed agonist activity by preventing TNF-alpha-induced apoptosis as efficiently as the hormones alone, providing further evidence to the notion that steroid receptor drugs may manifest agonist or antagonist activities depending on the cellular context in which they are studied.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	Raloxifene	Raloxifene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	RU486	RU486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ICI	ICI	PROPN	NNP	Number=Sing	_	_	_	_
14	182,780	182,780	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
25	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
31	as	as	SCONJ	IN	_	_	_	_	_
32	efficiently	efficiently	ADV	RB	_	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
36	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
39	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
40	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
47	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
48	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
49	manifest	manifest	VERB	VB	VerbForm=Inf	_	_	_	_
50	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
51	or	or	CCONJ	CC	_	_	_	_	_
52	antagonist	antagonist	ADJ	JJ	Degree=Pos	_	_	_	_
53	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
54	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
55	on	on	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
58	context	context	NOUN	NN	Number=Sing	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	which	which	PRON	WDT	PronType=Rel	_	_	_	_
61	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
62	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
63	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2512
# text = Treatment with E2 was also associated with a time-dependent decrease in the mRNA level of the proapoptotic Nip-2 protein, supporting the hypothesis that hormone responsiveness of U937 cells is mediated by target gene transcription.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proapoptotic	proapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
20	Nip	Nip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	hormone	hormone	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	U937	U937	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	target	target	NOUN	NN	Number=Sing	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2513
# text = Together, these results demonstrate that ER and PR can be activated by endogenous or exogenous ligands to induce a genetic response that impairs TNF-alpha-induced apoptosis in U937 cells.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	ER	er	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	PR	pr	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	impairs	impair	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	U937	U937	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2514
# text = The data presented here suggest that the female steroid receptors play a role in regulation of the immune response by preventing apoptosis of monoblastoid cells; this effect might have important consequences in the clinical use of steroid receptor drugs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	suggest	suggest	ADV	RBS	Degree=Sup	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
9	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
22	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	monoblastoid	monoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
29	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
30	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
36	use	use	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
39	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
40	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2515
# text = --Vegeto, E., Pollio, G., Pellicciari, C., Maggi, A.
1	--	--	PUNCT	NFP	_	_	_	_	SpaceAfter=No
2	Vegeto	Vegeto	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	E.	E.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Pollio	Pollio	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	G.	G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Pellicciari	Pellicciari	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	C.	c.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Maggi	Maggi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2516
# text = Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-inuced apoptosis.
1	Estrogen	Estrogen	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	monoblastoid	monoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	inuced	inuce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	apoptosis.	apoptosis.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2517
# text = Document 003003251 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003251	003003251	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2518
# text = Diminished responses to IL-13 by human monocytes differentiated in vitro: role of the IL-13Ralpha1 chain and STAT6.
1	Diminished	Diminish	ADJ	JJ	Degree=Pos	_	_	_	_
2	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13	13	NUM	CD	NumType=Card	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	Ralpha1	ralpha1	NUM	CD	NumType=Card	_	_	_	_
21	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	STAT6	Stat6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2519
# text = The primary IL-13 receptor complex on human monocytes is believed to be a heterodimer comprised of the IL-4R alpha chain and the IL-2R gamma chain (gamma(c))-like molecule, IL-13R alpha1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	13	13	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
17	comprised	comprise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	4R	4R	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
40	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
45	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2520
# text = mRNA levels for IL-13R alpha1, but not IL-4R alpha, were markedly decreased in in vitro monocyte-derived macrophages (MDMac), and with increasing time of monocytes in culture correlated with the loss of IL-13 regulation of lipopolysaccharide-induced TNF-alpha production.
1	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	IL	Il	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	markedly	markedly	ADV	RB	_	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
22	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	with	with	SCONJ	IN	_	_	_	_	_
32	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
33	time	time	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
38	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	13	13	NUM	CD	NumType=Card	_	_	_	_
46	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
54	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2521
# text = Analysis of cell lines Daudi and THP-1 that differentially express gamma(c) and IL-13R alpha1 showed that IL-13 can activate STAT6 in IL-13R alpha1-positive THP-1 cells but not in gamma(c)-positive, IL-13R alpha1-negative Daudi cells.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	that	that	ADV	WRB	PronType=Dem	_	_	_	_
11	differentially	differentially	ADV	RB	_	_	_	_	_
12	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	_
22	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	13	13	NUM	CD	NumType=Card	_	_	_	_
27	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
28	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
29	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
37	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	not	not	PART	RB	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
49	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	13R	13r	PROPN	NNP	Number=Sing	_	_	_	_
54	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
57	Daudi	Daudi	NOUN	NN	Number=Sing	_	_	_	_
58	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2522
# text = IL-13 activation of STAT6 was reduced in MDMac which was associated with diminished IL-13-induced expression of CD23 and MHC class II.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	13	13	NUM	CD	NumType=Card	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL-	Il-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
25	class	class	NOUN	NN	Number=Sing	_	_	_	_
26	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2523
# text = However, with reduced IL-13R alpha1 expression and low nuclear STAT6 activity, some IL-13-induced responses were unaltered in magnitude in MDMac.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	13R	13r	NOUN	NN	Number=Sing	_	_	_	_
8	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	STAT6	Stat6	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	some	some	DET	DT	_	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	unaltered	unalter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2524
# text = In the absence of functional IL-13R alpha1 and gamma(c), IL-13 must signal through an alternative receptor complex on MDMac.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	13	13	NUM	CD	NumType=Card	_	_	_	_
19	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
20	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2525
# text = Experiments with a blocking antibody to IL-4R alpha showed that this chain remains an essential component of the IL-13 receptor complex on MDMac.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	blocking	block	NOUN	NN	Number=Sing	_	_	_	_
5	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	4	for	X	GW	_	_	_	_	SpaceAfter=No
10	R	r	X	GW	_	_	_	_	_
11	alpha	alpha	X	GW	_	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	component	component	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	13	13	NUM	CD	NumType=Card	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2526
# text = Document 003003255 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003255	003003255	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2527
# text = A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	RanBP1	RanBP1	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	release	release	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CRM1	CRM1	PROPN	NNP	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	pore	pore	NOUN	NN	Number=Sing	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	step	step	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	export	export	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2528
# text = We recently developed an assay in which nuclear export of the shuttling transcription factor NFAT (nuclear factor of activated T cells) can be reconstituted in permeabilized cells with the GTPase Ran and the nuclear export receptor CRM1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	recently	recently	ADV	RB	_	_	_	_	_
3	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	export	export	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	shuttling	shuttling	VERB	VBG	VerbForm=Ger	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	permeabilized	permeabilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	GTPase	GTPase	PROPN	NNP	Number=Sing	_	_	_	_
33	Ran	ran	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	export	export	NOUN	NN	Number=Sing	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	CRM1	Crm1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2529
# text = We have now used this assay to identify another export factor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
9	another	another	DET	DT	_	_	_	_	_
10	export	export	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2530
# text = After preincubation of permeabilized cells with a Ran mutant that cannot hydrolyze GTP (RanQ69L), cytosol supports NFAT export, but CRM1 and Ran alone do not.
1	After	after	ADP	IN	_	_	_	_	_
2	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	permeabilized	permeabilize	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	Ran	ran	PROPN	NNP	Number=Sing	_	_	_	_
9	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
12	not	not	PART	RB	_	_	_	_	_
13	hydrolyze	hydrolyze	VERB	VB	VerbForm=Inf	_	_	_	_
14	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	RanQ69L	RanQ69L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
20	supports	support	NOUN	NNS	Number=Plur	_	_	_	_
21	NFAT	Nfat	PRON	WDT	PronType=Rel	_	_	_	_
22	export	export	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	CRM1	CRM1	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Ran	ran	PROPN	NNP	Number=Sing	_	_	_	_
28	alone	alone	ADV	RB	_	_	_	_	_
29	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2531
# text = The RanQ69L preincubation leads to accumulation of CRM1 at the cytoplasmic periphery of the nuclear pore complex (NPC) in association with the p62 complex and Can/Nup214.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	RanQ69L	Ranq69l	PROPN	NNP	Number=Sing	_	_	_	_
3	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
4	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	accumulation	accumulation	VERB	VB	VerbForm=Inf	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CRM1	CRM1	NOUN	NN	Number=Sing	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	periphery	periphery	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	pore	pore	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NPC	NPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	association	association	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	p62	p62	NOUN	NN	Number=Sing	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Can	Can	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Nup214	Nup214	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2532
# text = RanGTP-dependent association of CRM1 with these nucleoporins was reconstituted in vitro.
1	RanGTP-	RanGTP-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	association	association	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CRM1	CRM1	PROPN	NNP	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	nucleoporins	nucleoporin	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2533
# text = By biochemical fractionation and reconstitution, we showed that RanBP1 restores nuclear export after the RanQ69L preincubation.
1	By	by	ADP	IN	_	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	fractionation	fractionation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	RanBP1	RanBP1	PROPN	NNP	Number=Sing	_	_	_	_
11	restores	restore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	export	export	NOUN	NN	Number=Sing	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	RanQ69L	Ranq69l	NOUN	NN	Number=Sing	_	_	_	_
17	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2534
# text = It also stimulates nuclear export in cells that have not been preincubated with RanQ69L.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	export	export	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	RanQ69L	Ranq69l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2535
# text = RanBP1 as well as Ran-binding domains of the cytoplasmic nucleoporin RanBP2 promote the release of CRM1 from the NPC.
1	RanBP1	Ranbp1	NOUN	NN	Number=Sing	_	_	_	_
2	as	as	ADV	RB	_	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	Ran	ran	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	nucleoporin	nucleoporin	NOUN	NN	Number=Sing	_	_	_	_
13	RanBP2	Ranbp2	PART	TO	Abbr=Yes	_	_	_	_
14	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	release	release	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CRM1	Crm1	PROPN	NNP	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	NPC	Npc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2536
# text = Taken together, our results indicate that RanGTP is important for the targeting of export complexes to the cytoplasmic side of the NPC and that RanBP1 and probably RanBP2 are involved in the dissociation of nuclear export complexes from the NPC in a terminal step of transport.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	RanGTP	RanGTP	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	export	export	NOUN	NN	Number=Sing	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
20	side	side	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NPC	NPC	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	RanBP1	RanBP1	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	probably	probably	ADV	RB	_	_	_	_	_
29	RanBP2	Ranbp2	NOUN	NN	Number=Sing	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	export	export	NOUN	NN	Number=Sing	_	_	_	_
38	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	NPC	NPC	PROPN	NNP	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
45	step	step	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	transport	transport	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2537
# text = Document 003003265 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003265	003003265	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2538
# text = 1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Dihydroxyvitamin	Dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
4	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2539
# text = 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] induces differentiation and inhibits proliferation of myeloid leukemic cells from various lines and patients; these effects are probably mediated through the 1,25(OH)2D3 receptor.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Dihydroxyvitamin	Dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
4	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
5	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	]	]	PUNCT	-RRB-	_	_	_	_	_
12	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	probably	probably	ADV	RB	_	_	_	_	_
31	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	through	through	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
39	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2540
# text = Little is known of expression of 1,25(OH)2D3 receptor RNA in hematopoietic cells.
1	Little	little	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2541
# text = We examined the expression and modulation of expression of 1,25(OH)2D3 receptor RNA in various proliferating and nonproliferating hematopoietic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
19	proliferating	proliferating	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	nonproliferating	nonproliferat	VERB	VBG	VerbForm=Ger	_	_	_	_
22	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2542
# text = Constitutive expression of 1,25(OH)2D3 receptor
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2543
# text = RNA was detected in various kinds of hematopoietic cells, including macrophages and activated T lymphocytes, as well as in cell lines KG-1 (myeloblasts), HL-60 (promyelocytes), ML-3 (myelomonoblasts), U937, THP-1 (monoblasts), K562 (erythroblasts), and S-LB1 (HTLV-1-transfected T lymphocytes).
1	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
6	kinds	kind	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	KG	kg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	myeloblasts	myeloblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	HL	HL	SYM	$	_	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	60	60	NUM	CD	NumType=Card	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
40	3	3	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	myelomonoblasts	myelomonoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	monoblasts	monoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	K562	K562	NUM	CD	NumType=Card	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	S-	S-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	LB	lb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	1	1	NUM	CD	NumType=Card	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
69	T	t	PROPN	NNP	Number=Sing	_	_	_	_
70	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
71	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2544
# text = Receptor transcripts were 4.6 kilobases (kb), and no variant sizes were observed.
1	Receptor	Receptor	NOUN	NN	Number=Sing	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	4.6	4.6	NUM	CD	NumType=Card	_	_	_	_
5	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
13	sizes	size	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2545
# text = All cell lines examined in this group also expressed 1,25(OH)2D3 receptors.
1	All	all	DET	DT	_	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	group	group	NOUN	NN	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2546
# text = Most B lymphocyte lines expressed negligible levels of 1,25(OH)2D3 receptor
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
3	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	negligible	negligible	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2547
# text = RNA and protein; however; analysis of a lymphoid/myeloid somatic hybrid suggested that suppression of expression of 1,25(OH)2D3 receptor
1	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	;	;	PUNCT	,	_	_	_	_	_
5	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
6	;	;	PUNCT	,	_	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
13	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
14	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
15	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2548
# text = RNA in B lymphocytes may be a dominant characteristic.
1	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2549
# text = HL-60 cells were cultured with 10(-7) mol/L 1,25(OH)2D3 for 24 to 72 hours, and levels of expression of 1,25(OH)2D3 receptor and its RNA were examined.
1	HL	Hl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	60	60	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
10	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
13	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	72	72	NUM	CD	NumType=Card	_	_	_	_
22	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
37	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2550
# text = Levels of RNA coding for the receptor were not modulated by exposure to high levels of ligand.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
4	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2551
# text = Levels of occupied 1,25(OH)2D3 receptor protein increased in these HL-60 cells; but the total number of 1,25(OH)2D3 receptors decreased about 50% at 24 hours and returned toward normal at 72 hours.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	occupied	occupied	ADJ	JJ	Degree=Pos	_	_	_	_
4	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	60	60	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
22	number	number	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
29	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
30	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	about	about	ADV	RB	_	_	_	_	_
32	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	24	24	NUM	CD	NumType=Card	_	_	_	_
36	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	returned	return	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	toward	toward	ADP	IN	_	_	_	_	_
40	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
41	at	at	ADP	IN	_	_	_	_	_
42	72	72	NUM	CD	NumType=Card	_	_	_	_
43	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2552
# text = Steady-state levels of 1,25(OH)2D3 receptor
1	Steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	state	state	NOUN	NN	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2553
# text = RNA were not affected by terminal differentiation of HL-60 toward either granulocytes or macrophages.
1	RNA	RNA	NOUN	NN	Number=Sing	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	60	60	NUM	CD	NumType=Card	_	_	_	_
12	toward	toward	ADP	IN	_	_	_	_	_
13	either	either	DET	DT	_	_	_	_	_
14	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2554
# text = Nondividing macrophages from normal individuals also expressed 1,25(OH)2D3 receptor RNA.
1	Nondividing	Nondivid	VERB	VBG	VerbForm=Ger	_	_	_	_
2	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2555
# text = In contrast, nondividing peripheral blood lymphocytes from normal individuals did not express 1,25(OH)2D3 receptor RNA; with stimulation of proliferation of these cells, accumulation of 1,25(OH)2D3 receptor RNA increased markedly.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	nondividing	nondivid	VERB	VBG	VerbForm=Ger	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
14	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
38	RNA	RNa	SYM	SYM	_	_	_	_	_
39	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	markedly	markedly	ADV	RB	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2556
# text = Half-life (t1/2) of 1,25(OH)2D3 receptor
1	Half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	life	life	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	t1/2	t1/2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2557
# text = RNA in T lymphocytes was short (1 hour) as determined by measuring decay of the message after addition of actinomycin D. Consistent with this short t1/2, accumulation of 1,25(OH)2D3 receptor RNA increased in cells as their protein synthesis was inhibited.
1	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	hour	hour	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	measuring	measure	VERB	VBG	VerbForm=Ger	_	_	_	_
15	decay	decay	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	message	message	NOUN	NN	Number=Sing	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	actinomycin	actinomycin	ADP	IN	_	_	_	_	_
23	D.	D.	PROPN	NNP	Number=Sing	_	_	_	_
24	Consistent	consistent	PROPN	NNP	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
28	t1/2	t1/2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
38	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
39	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2558
# text = Further studies are required to understand the physiologic role of 1,25(OH)2D3 receptors in myeloid cells and proliferating T lymphocytes.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	proliferating	proliferat	VERB	VBG	VerbForm=Ger	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2559
# text = Document 003003267 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003267	003003267	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2560
# text = Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes.
1	Interleukin	Interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2561
# text = An early biochemical event associated with T cell activation through the interleukin-2 receptor (IL-2R) is tyrosine phosphorylation of several intracellular substrates.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
3	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
4	event	event	NOUN	NN	Number=Sing	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2R	2r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
26	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2562
# text = The exact mechanism by which IL-2 regulates transcription of different genes is presently unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	presently	presently	ADV	RB	_	_	_	_	_
16	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2563
# text = Here, we report that stimulation through the IL-2R induced tyrosine phosphorylation and subsequent nuclear translocation of stat3, a newly identified member of the signal transducers and activators of transcription (STAT) family of proteins.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	R	be	ADP	IN	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	newly	newly	ADV	RB	_	_	_	_	_
25	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	member	member	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
30	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	family	family	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2564
# text = In contrast, stat1 proteins were not tyrosine phosphorylated after IL-2 ligation, whereas tyrosine-phosphorylated stat1 proteins (91 and 84 kDa proteins) were translocated to the nucleus following interferon-gamma treatment of HeLa cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	stat1	stat1	NUM	CD	NumType=Card	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	tyrosine	tyrosine	ADV	RB	_	_	_	_	_
9	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	stat1	stat1	NOUN	NN	Number=Sing	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	91	91	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	84	84	NUM	CD	NumType=Card	_	_	_	_
26	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
34	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
35	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
38	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2565
# text = Apart from stat3, another cytoplasmic protein was tyrosine phosphorylated and subsequently translocated to the nucleus in response to IL-2.
1	Apart	apart	ADV	RB	_	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	another	another	DET	DT	_	_	_	_	_
6	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	tyrosine	tyrosine	ADV	RB	_	_	_	_	_
10	phosphorylated	phosphorylated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	subsequently	subsequently	ADV	RB	_	_	_	_	_
13	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2566
# text = This protein had an apparent molecular mass of 84 kDa and was not recognized by stat3 or stat1 mAb or antisera.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	84	84	NUM	CD	NumType=Card	_	_	_	_
10	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	stat3	stat3	NUM	CD	NumType=Card	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	stat1	stat1	NUM	CD	NumType=Card	_	_	_	_
19	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2567
# text = Since IL-2 induced nuclear translocation of the 84 kDa protein and stat3 followed identical kinetics, p84 is a candidate for a new, yet undefined, member of the STAT family.
1	Since	since	ADP	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	84	84	NUM	CD	NumType=Card	_	_	_	_
11	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	_
15	followed	follow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
17	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	p84	p84	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	yet	yet	CCONJ	CC	_	_	_	_	_
28	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	member	member	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
34	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2568
# text = Taken together, we report that IL-2 induces tyrosine phosphorylation and subsequent nuclear translocation of stat3 and an as yet undefined 84-kDa protein in antigen-specific human T cell lines.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	yet	yet	ADV	RB	_	_	_	_	_
23	undefined	undefin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	84	84	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2569
# text = Document 003003268 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003268	003003268	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2570
# text = Activation of nuclear factor-kappaB via T cell receptor requires a Raf kinase and Ca2+ influx.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
6	via	via	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	influx	influx	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2571
# text = Functional synergy between Raf and calcineurin.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	calcineurin	calcineurin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2572
# text = Signals transduced via the TCR activate the transcription factor nuclear factor-kappaB (NF-kappaB), which, in turn, is critical to the transcriptional induction of many genes important for the proliferation and expression of a differentiated phenotype.
1	Signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
2	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	via	via	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
6	activate	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
33	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2573
# text = Treatment of T cells with the protein kinase C activator PMA in combination with Ca2+ ionophores mimics this process, and the two agents are often substituted for TCR stimulation, bypassing the TCR.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	_
10	activator	activator	PROPN	NNP	Number=Sing	_	_	_	_
11	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	ionophores	ionophore	NOUN	NNS	Number=Plur	_	_	_	_
18	mimics	mimics	NOUN	NNS	Number=Plur	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	often	often	ADV	RB	_	_	_	_	_
28	substituted	substitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	TCR	Tcr	ADJ	JJR	Degree=Cmp	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	bypassing	bypasse	VERB	VBG	VerbForm=Ger	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2574
# text = Here we identify intracellular signaling components involved in activation of NF-kappaB following TCR stimulation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
6	components	component	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	TCR	Tcr	ADP	IN	_	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2575
# text = TCR signaling was triggered by treating Jurkat T cells with PHA or anti-CD3 Abs, and NF-kappaB activation was monitored by electrophoretic mobility shift assays and/or by kappaB-dependent reporter assays.
1	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	SCONJ	IN	_	_	_	_	_
6	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
14	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	or	or	CCONJ	CC	_	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
36	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2576
# text = Contrary to the idea that protein kinase C is involved in TCR-mediated activation of NF-kappaB, high doses of staurosporine did not interfere with activation of NF-kappaB by PHA, while the same dose of staurosporine completely blocked activation by PMA.
1	Contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	idea	idea	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C	c	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
22	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	while	while	SCONJ	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
40	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	_
43	completely	completely	ADV	RB	_	_	_	_	_
44	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2577
# text = PHA-induced kappaB-dependent reporter activity was, however, effectively blocked by a dominant negative form of Raf-1, suggesting a critical role for a Raf kinase.
1	PHA	Pha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	effectively	effectively	ADV	RB	_	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
18	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
19	form	form	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2578
# text = The TCR-mediated activation of NF-kappaB was also dependent on a Ca2+ influx, because the Ca2+ channel blocker, SK&F 96365, as well as other agents that prevented the Ca2+ influx, inhibited NF-kappaB activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	influx	influx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	channel	channel	NOUN	NN	Number=Sing	_	_	_	_
24	blocker	blocker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	SK&F	SK&F	PROPN	NNP	Number=Sing	_	_	_	_
27	96365	96365	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	ADV	RB	_	_	_	_	_
30	well	well	ADV	RB	Degree=Pos	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	+	+	CCONJ	CC	_	_	_	_	_
39	influx	influx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2579
# text = Cotransfection of a constitutively active form of calcineurin largely substituted for the Ca2+ requirement and reversed the blockade by SK&F 96365.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
9	largely	largely	ADV	RB	_	_	_	_	_
10	substituted	substitute	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	+	+	CCONJ	CC	_	_	_	_	_
15	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	reversed	reverse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	SK&F	SK&F	PROPN	NNP	Number=Sing	_	_	_	_
22	96365	96365	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2580
# text = Consistent with these observations, coexpression of constitutively active forms of Raf-1 and calcineurin synergistically induced kappaB-dependent reporter activity, suggesting a physiologically relevant functional interaction between the kinase and the phosphatase.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	observations	observation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
10	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	calcineurin	calcineurin	VERB	VB	VerbForm=Inf	_	_	_	_
17	synergistically	synergistically	ADV	RB	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	physiologically	physiologically	ADV	RB	_	_	_	_	_
28	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
29	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
30	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2581
# text = Document 003003270 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003270	003003270	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2582
# text = Increased proliferation, cytotoxicity, and gene expression after stimulation of human peripheral blood T lymphocytes through a surface ganglioside (GD3) [published erratum appears in J Immunol 1994 Jul 15;153(2):910] Previous studies have suggested that gangliosides have an important role in cell signaling and recognition.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
20	ganglioside	ganglioside	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	GD3	GD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
27	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	J	j	PROPN	NNP	Number=Sing	_	_	_	_
30	Immunol	Immunol	PROPN	NNP	Number=Sing	_	_	_	_
31	1994	1994	NUM	CD	NumType=Card	_	_	_	_
32	Jul	Jul	PROPN	NNP	Number=Sing	_	_	_	_
33	15;153	15;153	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	:910	:910	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
39	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
40	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
41	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
42	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	that	that	SCONJ	IN	_	_	_	_	_
44	gangliosides	ganglioside	NOUN	NNS	Number=Plur	_	_	_	_
45	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
48	role	role	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2583
# text = However, their specific function in these processes has not been clearly defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	processes	processe	NOUN	NNS	Number=Plur	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	clearly	clearly	ADV	RB	_	_	_	_	_
13	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2584
# text = A mAb, R24, that reacts specifically with a cell surface ganglioside (GD3) has been demonstrated to stimulate proliferation of T cells derived from human peripheral blood.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	R24	R24	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	reacts	react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
13	ganglioside	ganglioside	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GD3	GD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2585
# text = In this study, we have investigated the mechanisms by which the R24 mAb affects T cell functions.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	R24	R24	PROPN	NNP	Number=Sing	_	_	_	_
14	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
15	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2586
# text = We have observed that the R24 mAb stimulates GD3+ T cell proliferation, cytotoxicity, and surface marker expression of IL-2R alpha-chain, IL-2R beta-chain, HLA-DR, CD11a, and CD11c. Additionally, IFN-gamma activity but not IL-1, IL-2, or IL-4 activity was present in culture supernatants 72 h after R24 stimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	R24	R24	PROPN	NNP	Number=Sing	_	_	_	_
7	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
8	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	GD3	GD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
25	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2R	2R	NOUN	NN	Number=Sing	_	_	_	_
30	beta-	beta-	PUNCT	:	_	_	_	_	SpaceAfter=No
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	HLA-DR	HLA-DR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	CD11a	CD11a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	CD	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	11c	11c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_
41	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	IFN	IFN	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	but	but	CCONJ	CC	_	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	or	or	CCONJ	CC	_	_	_	_	_
58	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	4	4	NUM	CD	NumType=Card	_	_	_	_
61	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
62	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
63	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
64	in	in	ADP	IN	_	_	_	_	_
65	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
66	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
67	72	72	NUM	CD	NumType=Card	_	_	_	_
68	h	h	NOUN	NN	Number=Sing	_	_	_	_
69	after	after	ADP	IN	_	_	_	_	_
70	R24	R24	NUM	CD	NumType=Card	_	_	_	_
71	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2587
# text = In some donors, increased IL-6 and TNF-alpha activity also was detected after R24 treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	some	some	DET	DT	_	_	_	_	_
3	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	R24	R24	NUM	CD	NumType=Card	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2588
# text = Furthermore, R24 treatment resulted in translocation of c-rel, but little or no NF kappa B p50 or p65, from the cytoplasm to the nucleus and an increase of NF kappa B binding complexes containing c-rel and p50.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	R24	R24	NUM	CD	NumType=Card	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	p50	p50	NUM	CD	NumType=Card	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	_
36	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
37	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
38	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
40	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2589
# text = This treatment also caused increased tyrosine phosphorylation of specific protein substrates.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	substrates	substrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2590
# text = R24-stimulated increases in proliferation, cytotoxicity, and cell surface protein expression could be blocked by cyclosporin and staurosporin, indicating that cyclophilin/calcineurin and protein kinase C may be involved in the R24 signaling pathway.
1	R24	R24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-stimulated	-stimulate	ADJ	JJ	Degree=Pos	_	_	_	_
3	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	staurosporin	staurosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	C	c	PROPN	NNP	Number=Sing	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	R24	R24	PROPN	NNP	Number=Sing	_	_	_	_
37	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
38	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2591
# text = Additionally, herbimycin A, a tyrosine kinase inhibitor, blocked the R24-stimulated increase in proliferation but not cytotoxicity at concentrations consistent with specificity for tyrosine kinases.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	herbimycin	herbimycin	ADP	IN	_	_	_	_	_
4	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	R24	R24	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-stimulated	-stimulated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
23	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
28	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2592
# text = These results suggest that multiple biochemical pathways are involved in the activation of human T cells by R24.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
7	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	R24	R24	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2593
# text = Document 003003272 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003272	003003272	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2594
# text = Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients.
1	Nuclear	nuclear	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	hallmark	hallmark	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	CLL	CLL	PROPN	NNP	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2595
# text = B lymphocytes from the peripheral blood of patients with chronic lymphocytic leukaemia (CLL) were analysed for the nuclear presence and DNA binding of a panel of transcription factors which are involved in the gene control of lymphoid cells.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CLL	Cll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	control	control	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2596
# text = The following transcription factors were studied: the Octamer factors Oct-1 and Oct-2, members of the AP-1 factor family, NF-AT factors, in particular NF-ATp, and members of the Rel/NF-kB family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Octamer	Octamer	PROPN	NNP	Number=Sing	_	_	_	_
10	factors	factor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	AT	at	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	members	member	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Rel/	Rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
46	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2597
# text = We show that the constitutive nuclear translocation of NF-ATp, a member of the growing family of NF-AT factors, is a hallmark of nonstimulated B cells from CLL patients that distinguishes B-CLL cells from 'normal' B lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	member	member	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	AT	AT	ADP	IN	_	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	hallmark	hallmark	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	nonstimulated	nonstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	CLL	CLL	DET	DT	_	_	_	_	_
34	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	distinguishes	distinguish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	CLL	Cll	NOUN	NN	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
43	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	'	'	PUNCT	''	_	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2598
# text = Constitutive nuclear appearance was also observed for NF-kB2/p52.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	NF-	NF-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	kB2/	kB2/	SYM	SYM	_	_	_	_	SpaceAfter=No
10	p52	p52	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2599
# text = Constitutive binding of further factor proteins to DNA, such as JunD, c-Fos and FosB, was detected in several patients whereas the localisation and DNA binding of other factors such as c-Jun, RelA/p65 and c-Rel was unaltered.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	FosB	FosB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	localisation	localisation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
33	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	unaltered	unalter	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2600
# text = It is remarkable that in B-CLL cells the nuclear appearance and DNA binding of specific transcription factors is dramatically affected whereas other members of the same factor family remained unaltered in these leukemic cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	remarkable	remarkable	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CLL	CLL	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	dramatically	dramatically	ADV	RB	_	_	_	_	_
22	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	members	member	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	unaltered	unaltered	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2601
# text = It remains to be shown which molecular events lead to the specific 'pre-activation', i.e.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	which	which	DET	WDT	PronType=Int	_	_	_	_
7	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
14	pre-activation	pre-activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	i.e.	i.e.	X	FW	_	_	_	_	_

# sent_id = 2602
# text = constitutive nuclear translocation and DNA binding, of these members of NF-AT, NF-kB and AP-1 factor families.
1	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2603
# text = Document 003003277 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003277	003003277	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2604
# text = MDS1/EVI1 enhances TGF-beta1 signaling and strengthens its growth-inhibitory effect but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-beta1.
1	MDS1/EVI1	MDS1/EVI1	NUM	CD	NumType=Card	_	_	_	_
2	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
3	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	strengthens	strengthen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	AML1/MDS1/EVI1	Aml1/mds1/evi1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	product	product	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	3;21	3;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-inhibition	-inhibition	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2605
# text = MDS1/EVI1, located on chromosome 3 band q26, encodes a zinc-finger DNA-binding transcription activator not detected in normal hematopoietic cells but expressed in several normal tissues.
1	MDS1/EVI1	MDS1/EVI1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	band	band	NOUN	NN	Number=Sing	_	_	_	_
8	q26	q26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2606
# text = MDS1/EVI1 is inappropriately activated in myeloid leukemias following chromosomal rearrangements involving band 3q26.
1	MDS1/EVI1	Mds1/evi1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	inappropriately	inappropriately	ADV	RB	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
7	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
10	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
11	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
12	band	band	NOUN	NN	Number=Sing	_	_	_	_
13	3q	3q	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2607
# text = The rearrangements lead either to gene truncation, and to expression of the transcription repressor EVI1, as seen in the t(3;3)(q21;q26) and inv(3)(q21q26), or to gene fusion, as seen in the t(3;21)(q26;q22) which results in the fusion protein AML1/MDS1/EVI1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
3	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	either	either	ADV	RB	_	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
7	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	EVI1	EVI1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	3;3)	3;3)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	q21;q26	q21;q26	X	LS	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	inv	inv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	3)	3)	SYM	NFP	_	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	q21q26	q21q26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
39	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	as	as	SCONJ	IN	_	_	_	_	_
42	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	t(	t(	SYM	NFP	_	_	_	_	SpaceAfter=No
46	3;21	3;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	q26;q22	q26;q22	X	LS	_	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	which	which	DET	WDT	PronType=Int	_	_	_	_
52	results	result	NOUN	NNS	Number=Plur	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
56	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
57	AML1/MDS1/EVI1	AML1/MDS1/EVI1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2608
# text = This fusion protein contains the DNA-binding domain of the transcription factor AML1 fused in-frame to the entire MDS1/EVI1 with the exclusion of its first 12 amino acids.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
15	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
22	MDS1/EVI1	Mds1/evi1	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	exclusion	exclusion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
29	12	12	NUM	CD	NumType=Card	_	_	_	_
30	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
31	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2609
# text = In this report, we have analyzed the response of the hematopoietic precursor cell line 32Dcl3, expressing either the normal protein MDS1/EVI1 or the fusion protein AML1/MDS1/EVI1, to factors that control cell differentiation or cell replication.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
13	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	Dcl3	Dcl3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	either	either	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	MDS1/EVI1	Mds1/evi1	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	AML1/MDS1/EVI1	AML1/MDS1/EVI1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2610
# text = The 32Dcl3 cells are IL-3-dependent for growth and they differentiate into granulocytes when exposed to G-CSF.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	Dcl3	Dcl3	NOUN	NN	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	differentiate	differentiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	into	into	ADP	IN	_	_	_	_	_
17	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	G-	G-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2611
# text = They are growth-inhibited by TGF-beta1.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	beta1	beta1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2612
# text = We show that whereas the expression of MDS1/EVI1 has no effect on granulocytic differentiation induced by G-CSF, expression of AML1/MDS1/EVI1 blocks differentiation resulting in cell death.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	whereas	whereas	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	MDS	MDS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EVI1	Evi1	PROPN	NNP	Number=Sing	_	_	_	_
12	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	AML1/MDS1/EVI1	AML1/MDS1/EVI1	NUM	CD	NumType=Card	_	_	_	_
26	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2613
# text = This effect is similar to that previously described by others for 32Dcl3 cells that express transgenic Evil.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	previously	previously	ADV	RB	_	_	_	_	_
8	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	others	other	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	Evil	evil	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2614
# text = Furthermore, we show that whereas the expression of the fusion protein AML1/MDS1/EVI1 completely abrogates the growth-inhibitory effect of TGF-beta1 and allows 32Dcl3 cells to proliferate, expression of the normal protein MDS1/EVI1 has the opposite effect, and it strengthens the response of cells to the growth-inhibitory effect of TGF-beta1.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	whereas	whereas	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
13	AML1/MDS1/EVI1	AML1/MDS1/EVI1	PROPN	NNP	Number=Sing	_	_	_	_
14	completely	completely	ADV	RB	_	_	_	_	_
15	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	MDS	mds	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
42	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
49	strengthens	strengthen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	response	response	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	to	to	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
59	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2615
# text = By using the yeast two-hybrid system, we also show that EVI1 (contained in its entirety in MDS1/EVI1 and AML1/MDS1/EVI1) physically interacts with SMAD3, which is an intracellular mediator of TGF-beta1 signaling.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
8	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	entirety	entirety	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	MDS1/EVI1	Mds1/evi1	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	AML1/MDS1/EVI1	Aml1/mds1/evi1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	physically	physically	ADV	RB	_	_	_	_	_
26	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	SMAD3	SMAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
34	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
39	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2616
# text = Finally, we have correlated the response of the cells to G-CSF or TGF-beta1 with the ability of the normal and fusion proteins to activate or repress promoters which they can directly regulate by binding to the promoter site.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
31	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	directly	directly	ADV	RB	_	_	_	_	_
36	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
37	by	by	SCONJ	IN	_	_	_	_	_
38	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
42	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2617
# text = We propose that mutations of MDS1/EVI1 either by gene truncation resulting in the transcription repressor EVI1 or by gene fusion to AML1 lead to an altered cellular response to growth and differentiation factors that could result in leukemic transformation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MDS1	MDS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
13	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	AML1	AML1	NUM	CD	NumType=Card	_	_	_	_
25	lead	lead	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
36	that	that	PRON	WDT	PronType=Rel	_	_	_	_
37	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
38	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
41	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2618
# text = The different response of myeloid cells ectopically expressing the normal or the fusion protein to G-CSF and TGF-beta1 could depend on the different transactivation properties of these proteins resulting in divergent expression of downstream genes regulated by the two proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	ectopically	ectopically	ADV	RB	_	_	_	_	_
8	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
28	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	two	two	NUM	CD	NumType=Card	_	_	_	_
43	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2619
# text = Document 003003280 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003280	003003280	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2620
# text = [Glucocorticoid receptors in peripheral blood lymphocytes of patients with bronchial asthma] Quantitation of glucocorticoid receptors (GCR) and the study of their affinity for glucocorticosteroids (GCS) were made in peripheral blood lymphocytes of bronchial asthma (BA) patients in consideration of GCR treatment and serum levels of endogenous cortisol.
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Glucocorticoid	Glucocorticoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
12	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
14	Quantitation	Quantitation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	study	study	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	glucocorticosteroids	glucocorticosteroid	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	GCS	Gc	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	made	make	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
36	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
40	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	BA	BA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	consideration	consideration	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	GCR	Gcr	ADJ	JJ	Degree=Pos	_	_	_	_
49	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
55	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2621
# text = It is stated that GCR of healthy controls and GCS-untreated patients outnumbered those of cortisol-dependent BA patients on hormone therapy.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	stated	state	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GCR	Gcr	ADP	IN	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
8	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	GCS	Gc	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	untreated	untreate	ADJ	JJ	Degree=Pos	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	outnumbered	outnumber	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	BA	Ba	NOUN	NN	Number=Sing	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
24	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2622
# text = Following discontinuation of glucocorticoid drugs GCR count in cortisol-dependent BA tends to rise.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	discontinuation	discontinuation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
6	GCR	Gcr	ADP	IN	_	_	_	_	_
7	count	count	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cortisol	cortisol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	BA	Ba	NOUN	NN	Number=Sing	_	_	_	_
13	tends	tend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	rise	rise	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2623
# text = Endogenous cortisol has no effect on GCR level estimated by 3H-triamcinolone acetonide.
1	Endogenous	Endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	GCR	Gcr	ADJ	JJ	Degree=Pos	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	estimated	estimate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	3H	3h	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	triamcinolone	triamcinolone	ADJ	JJ	Degree=Pos	_	_	_	_
14	acetonide	acetonide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2624
# text = Document 003003282 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003282	003003282	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2625
# text = Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia?
1	Does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TAL1	tAL1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	occur	occur	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	acute	acute	X	ADD	_	_	_	_	_
17	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
18	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	?	?	PUNCT	.	_	_	_	_	_

# sent_id = 2626
# text = A pediatric oncology group study.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	pediatric	pediatric	ADJ	JJ	Degree=Pos	_	_	_	_
3	oncology	oncology	NOUN	NN	Number=Sing	_	_	_	_
4	group	group	NOUN	NN	Number=Sing	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2627
# text = Almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene.
1	Almost	almost	ADV	RB	_	_	_	_	_
2	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	%	%	SYM	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	tumor-	tumor-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2628
# text = Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	products	product	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	readily	readily	ADV	RB	_	_	_	_	_
17	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	harbor	harbor	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
26	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2629
# text = Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
12	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2630
# text = In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	TAL1	TAL1	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	display	display	VERB	VB	VerbForm=Inf	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
31	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2631
# text = A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
3	dinucleotide	dinucleotide	NOUN	NN	Number=Sing	_	_	_	_
4	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TAL1	tAL1	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
17	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	ALL	all	DET	DT	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2632
# text = Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement.
1	Monoallelic	Monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TAL1	tAL1	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	all	all	DET	DT	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2633
# text = In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
7	without	without	ADP	IN	_	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	TAL1	tAL1	NUM	CD	NumType=Card	_	_	_	_
10	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	monoallelic	monoallelic	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	7	7	NUM	CD	NumType=Card	_	_	_	_
23	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	biallelic	biallelic	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2634
# text = Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles).
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
12	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
25	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
26	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	both	both	DET	DT	_	_	_	_	_
44	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
45	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2635
# text = Document 003003283 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003283	003003283	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2636
# text = BCL-6 and the molecular pathogenesis of B-cell lymphoma.
1	BCL	BCL	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2637
# text = The results presented identify the first genetic lesion associated with DLCL, the most clinically relevant form of NHL.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	presented	present	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADV	RBS	_	_	_	_	_
7	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
8	lesion	lesion	NOUN	NN	Number=Sing	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	DLCL	DLCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	most	most	ADV	RBS	_	_	_	_	_
15	clinically	clinically	ADV	RB	_	_	_	_	_
16	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NHL	NHL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2638
# text = Although no proof yet exists of a role for these lesions in DLCL pathogenesis, the feature of the BCL-6 gene product, its specific pattern of expression in B cells, and the clustering of lesions disrupting its regulatory domain strongly suggest that deregulation of BCL-6 expression may contribute to DLCL development.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	no	no	DET	DT	_	_	_	_	_
3	proof	proof	NOUN	NN	Number=Sing	_	_	_	_
4	yet	yet	ADV	RB	_	_	_	_	_
5	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	DLCL	DLCL	PROPN	NNP	Number=Sing	_	_	_	_
14	pathogenesis	pathogenesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	clustering	clustering	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
40	disrupting	disrupt	VERB	VBG	VerbForm=Ger	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
43	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
44	strongly	strongly	ADV	RB	_	_	_	_	_
45	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
46	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
47	deregulation	deregulation	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	6	6	NUM	CD	NumType=Card	_	_	_	_
52	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
53	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
54	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
55	to	to	PART	TO	_	_	_	_	_
56	DLCL	Dlcl	VERB	VB	VerbForm=Inf	_	_	_	_
57	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2639
# text = A more precise definition of the role of BCL-6 in normal and neoplastic B-cell development is the goal of ongoing study of transgenic mice engineered either to express BCL-6 under heterologous promoters or lacking BCL-6 function due to targeted deletions.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	more	more	ADV	RBR	_	_	_	_	_
3	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
4	definition	definition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	goal	goal	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
25	study	study	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
28	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
29	engineered	engineer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	either	either	ADV	RB	_	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
33	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	under	under	ADP	IN	_	_	_	_	_
37	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
38	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
41	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	6	6	NUM	CD	NumType=Card	_	_	_	_
44	function	function	NOUN	NN	Number=Sing	_	_	_	_
45	due	due	ADP	IN	_	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2640
# text = In addition to contributing to the understanding of DLCL pathogenesis, the identification of BCL-6 lesions may have relevant clinical implications.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	SCONJ	IN	_	_	_	_	_
4	contributing	contribute	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	DLCL	DLCL	PROPN	NNP	Number=Sing	_	_	_	_
10	pathogenesis	pathogenesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
21	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
22	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
23	implications	implication	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2641
# text = DLCL represent a heterogeneous group of neoplasms which are treated homogeneously despite the fact that only 50% of patients experience long-term disease-free survival (Schneider et al.
1	DLCL	DLCL	AUX	MD	VerbForm=Fin	_	_	_	_
2	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
5	group	group	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	neoplasms	neoplasm	NOUN	NNS	Number=Plur	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	homogeneously	homogeneously	ADV	RB	_	_	_	_	_
12	despite	despite	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
21	experience	experience	NOUN	NN	Number=Sing	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	term	term	NOUN	NN	Number=Sing	_	_	_	_
25	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
28	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	Schneider	Schneider	NOUN	NN	Number=Sing	_	_	_	_
31	et	et	X	FW	_	_	_	_	_
32	al.	al.	X	FW	_	_	_	_	_

# sent_id = 2642
# text = 1990).
1	1990	1990	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2643
# text = The fact that BCL-6 rearrangements identify biologically and clinically distinct subsets of DLCL suggests that these lesions may be useful as markers in selection of differential therapeutic strategies based on different risk groups.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
8	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	biologically	biologically	ADV	RB	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	clinically	clinically	ADV	RB	_	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	DLCL	DLCL	PROPN	NNP	Number=Sing	_	_	_	_
16	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
29	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
30	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
31	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
34	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
35	groups	group	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2644
# text = Furthermore, the BCL-6 rearrangements can be used to identify and monitor the malignant clone with sensitive PCR-based techniques.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
17	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	techniques	technique	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2645
# text = Since clinical remission has been observed in a significant fraction of DLCL cases, these markers may serve as critical tools for sensitive monitoring of minimal residual disease and early diagnosis of relapse (Gribben et al.
1	Since	since	ADP	IN	_	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	remission	remission	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	DLCL	Dlcl	ADJ	JJ	Degree=Pos	_	_	_	_
13	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
21	tools	tool	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
24	monitoring	monitoring	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
27	residual	residual	ADJ	JJ	Degree=Pos	_	_	_	_
28	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
31	diagnosis	diagnosis	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	relapse	relapse	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	Gribben	Gribben	PROPN	NNP	Number=Sing	_	_	_	_
36	et	et	X	FW	_	_	_	_	_
37	al.	al.	X	FW	_	_	_	_	_

# sent_id = 2646
# text = 1993).
1	1993	1993	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2647
# text = Document 003003284 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003284	003003284	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2648
# text = Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1.
1	Attenuation	Attenuation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Leishmania	Leishmania	PROPN	NNP	Number=Sing	_	_	_	_
15	donovani	donovani	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
23	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2649
# text = The induction of gene transcription in response to gamma interferon is impaired in mononuclear phagocytes infected with Leishmania donovani, and the mechanisms involved are not fully understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	Leishmania	Leishmania	PROPN	NNP	Number=Sing	_	_	_	_
19	donovani	donovani	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	fully	fully	ADV	RB	_	_	_	_	_
28	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2650
# text = The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases, including the Janus kinases Jak1 and Jak2, leading to tyrosine phosphorylation of the transcription factor Stat1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	brought	bring	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	about	about	ADV	RB	_	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
29	kinases	kinase	PROPN	NNPS	Number=Plur	_	_	_	_
30	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	tyrosine	tyrosine	VERB	VB	VerbForm=Inf	_	_	_	_
37	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
42	Stat1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2651
# text = To investigate the mechanisms accounting for the impaired responses to gamma interferon, a model system for examining overall changes in protein tyrosine phosphorylation, activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate-differentiated U-937 cells.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	accounting	accounte	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
9	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
12	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	model	model	NOUN	NN	Number=Sing	_	_	_	_
16	system	system	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	SCONJ	IN	_	_	_	_	_
18	examining	examine	VERB	VBG	VerbForm=Ger	_	_	_	_
19	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
20	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
39	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
42	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
49	937	937	NUM	CD	NumType=Card	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2652
# text = Analysis of whole-cell lysates by antiphosphotyrosine immunoblotting showed that incubation with gamma interferon brought about specific increases in phosphotyrosine labeling of several proteins.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	antiphosphotyrosine	antiphosphotyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunoblotting	immunoblott	NOUN	NN	Number=Sing	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
15	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
16	brought	bring	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	about	about	ADP	IN	_	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	phosphotyrosine	phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2653
# text = Increased labeling of these proteins occurred to similar extents in control cells and in cells that had been infected with L. donovani for 16 h.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
9	extents	extent	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	control	control	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
22	donovani	donovani	PROPN	NNP	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	16	16	NUM	CD	NumType=Card	_	_	_	_
25	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2654
# text = Jak1, Jak2, and Stat1 were immunoprecipitated from control and interferon-treated cells, and tyrosine phosphorylation of these proteins, detected by antiphosphotyrosine immunoblotting was used to measured their activation.
1	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Jak2	jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	immunoprecipitated	immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	antiphosphotyrosine	antiphosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	immunoblotting	immunoblotting	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	used	use	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2655
# text = Tyrosine phosphorylation of Jak1, Jak2, and Stat1 increased markedly, in a dose-dependent manner, in U-937 cells incubated with gamma interferon.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Jak2	jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	markedly	markedly	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	937	937	NUM	CD	NumType=Card	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
28	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2656
# text = In contrast, in cells infected with L.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2657
# text = donovani, tyrosine phosphorylation of Jak1, Jak2, and Stat1 was markedly impaired.
1	donovani	donovani	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Jak2	jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	markedly	markedly	ADV	RB	_	_	_	_	_
14	impaired	impaired	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2658
# text = This effect was dependent upon the duration of exposure to L. donovani and was maximal and complete at 16 h.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	upon	upon	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
12	donovani	donovani	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	16	16	NUM	CD	NumType=Card	_	_	_	_
20	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2659
# text = Results similar to those observed with U-937 cells were also obtained with human peripheral blood monocytes.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2660
# text = These findings indicate that infection of human mononuclear phagocytes with L. donovani leads to impaired gamma interferon-mediated tyrosine phosphorylation and selective effects on the Jak-Stat1 pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
9	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
12	donovani	donovani	PROPN	NNP	Number=Sing	_	_	_	_
13	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	impaired	impaired	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
24	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2661
# text = Unresponsiveness to gamma interferon for activation of this pathway may explain impaired transcriptional responses in leishmania-infected cells.
1	Unresponsiveness	Unresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
12	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	leishmania	leishmania	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2662
# text = Document 003003287 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003287	003003287	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2663
# text = Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2664
# text = T cell expression of interleukin 3 (IL-3) is directed by positive and negative cis-acting DNA elements clustered within 300 base pairs of the transcriptional start site.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
22	clustered	cluster	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	300	300	NUM	CD	NumType=Card	_	_	_	_
25	base	base	NOUN	NN	Number=Sing	_	_	_	_
26	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	start	start	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2665
# text = A strong repressor element, termed nuclear inhibitory protein (NIP), was previously mapped to a segment of the IL-3 promoter between nucleotides -271 and -250.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
3	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NIP	NIP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	previously	previously	ADV	RB	_	_	_	_	_
16	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	271	271	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	250	250	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2666
# text = Functional characterization of this element demonstrates that it can mediate repression when linked in cis to a heterologous promoter.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
11	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2667
# text = DNA binding experiments were carried out to characterize the repressor activity.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	out	out	ADV	RB	_	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2668
# text = Using varying conditions, three distinct complexes were shown to interact specifically with the NIP region, although only one correlates with repressor activity.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	varying	varying	VERB	VBG	VerbForm=Ger	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	three	three	NUM	CD	NumType=Card	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NIP	Nip	PROPN	NNP	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2669
# text = Complex 1 results from binding of a ubiquitous polypeptide that recognizes the 3' portion of this sequence and is not required for repression.
1	Complex	complex	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	1	1	NUM	CD	NumType=Card	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	SCONJ	IN	_	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
9	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2670
# text = Complex 2 corresponds to binding of transcription factor (upstream stimulatory factor) to an E-box motif in the 5' portion of the NIP region.
1	Complex	complex	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	corresponds	corresponds	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	SCONJ	IN	_	_	_	_	_
5	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	's	PUNCT	``	_	_	_	_	_
23	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NIP	NIP	PROPN	NNP	Number=Sing	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2671
# text = DNA binding specificity of complex 3 overlaps with that of upstream stimulatory factor but is clearly distinct.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
3	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	overlaps	overlaps	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
12	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	clearly	clearly	ADV	RB	_	_	_	_	_
17	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2672
# text = To determine which of the latter two complexes represents NIP activity, we incorporated small alterations into the NIP site of an IL-3 promoter-linked reporter construct and examined their effects on NIP-mediated repression.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	which	which	PRON	WDT	PronType=Int	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	NIP	Nip	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	incorporated	incorporate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
16	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NIP	NIP	PROPN	NNP	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	NIP-	NIP-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2673
# text = Functional specificity for repression matches the DNA binding specificity of complex 3; both repressor activity and complex 3 binding require the consensus sequence CTCACNTNC.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	matches	match	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
9	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	CTCACNTNC	Ctcacntnc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2674
# text = Document 003003292 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003292	003003292	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2675
# text = Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	12	12	NUM	CD	NumType=Card	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	STAT4	Stat4	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2676
# text = Interleukin 12 (IL-12) is an important immunoregulatory cytokine whose receptor is a member of the hematopoietin receptor superfamily.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	12	12	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	member	member	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hematopoietin	hematopoietin	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2677
# text = We have recently demonstrated that stimulation of human T and natural killer cells with IL-12 induces tyrosine phosphorylation of the Janus family tyrosine kinase JAK2 and Tyk2, implicating these kinases in the immediate biochemical response to IL-12.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
12	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	12	12	NUM	CD	NumType=Card	_	_	_	_
18	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	JAK2	Jak2	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Tyk2	tyk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
37	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
38	response	response	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2678
# text = Recently, transcription factors known as STATs (signal transducers and activators of transcription) have been shown to be tyrosine phosphorylated and activated in response to a number of cytokines that bind hematopoietin receptors and activate JAK kinases.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	STATs	STATs	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
22	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	number	number	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	hematopoietin	hematopoietin	ADJ	JJ	Degree=Pos	_	_	_	_
35	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
38	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	_
39	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2679
# text = In this report we demonstrate that IL-12 induces tyrosine phosphorylation of a recently identified
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	12	12	NUM	CD	NumType=Card	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	recently	recently	ADV	RB	_	_	_	_	_
16	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2680
# text = STAT family member, STAT4, and show that STAT4 expression is regulated by T-cell activation.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	STAT4	STAT4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	STAT4	STAT4	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2681
# text = Furthermore, we show that IL-12 stimulates formation of a DNA-binding complex that recognizes a DNA sequence previously shown to bind STAT proteins and that this complex contains STAT4.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	12	12	NUM	CD	NumType=Card	_	_	_	_
9	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
10	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
22	previously	previously	ADV	RB	_	_	_	_	_
23	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
26	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
32	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	STAT4	STAT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2682
# text = These data, and the recent demonstration of JAK phosphorylation by IL-12, identify a rapid signal-transduction pathway likely to mediate IL-12-induced gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
7	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	identify	identify	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	likely	likely	ADV	RB	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2683
# text = Document 003003295 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003295	003003295	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2684
# text = Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma.
1	Heterogeneous	Heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	endemic	endemic	ADJ	JJ	Degree=Pos	_	_	_	_
12	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	's	's	PART	POS	_	_	_	_	_
14	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2685
# text = Epstein-Barr virus (EBV)-infected cells may sustain three distinct forms of virus latency.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	sustain	sustain	VERB	VB	VerbForm=Inf	_	_	_	_
13	three	three	NUM	CD	NumType=Card	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2686
# text = In lymphoblastoid cell lines, six EBV-encoded nuclear antigens (EBNA1, 2, 3A, 3B, 3C, -LP), three latent membrane proteins (LMP1, 2A, 2B), and two nuclear RNAs (EBERs) are expressed.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	six	six	NUM	CD	NumType=Card	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	encoded	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	EBNA1	EBNA1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	3A	3a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	3B	3B	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	3C	3C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	LP	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	three	three	NUM	CD	NumType=Card	_	_	_	_
28	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
29	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	2A	2a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	2B	2B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	two	two	NUM	CD	NumType=Card	_	_	_	_
41	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
42	RNAs	RNAs	PROPN	NNPS	Number=Plur	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	EBERs	EBERs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2687
# text = This form of latency, termed latency III, is also encountered in some posttransplant lymphoproliferative disorders.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	form	form	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
8	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	encountered	encounter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	some	some	DET	DT	_	_	_	_	_
15	posttransplant	posttransplant	ADJ	JJ	Degree=Pos	_	_	_	_
16	lymphoproliferative	lymphoproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
17	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2688
# text = In EBV-positive cases of Hodgkin's disease, the EBERs, EBNA1, and the LMPs are expressed (latency II), whereas in Burkitt's lymphoma (BL) only the EBERs and EBNA1 have been detected (latency I).
1	In	in	ADP	IN	_	_	_	_	_
2	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EBERs	EBERs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	EBNA1	EBNA1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	LMPs	LMP	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	wherea	ADV	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	's	's	PART	POS	_	_	_	_	_
30	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	only	only	ADV	RB	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	EBERs	EBERs	PROPN	NNPS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	EBNA1	EBNA1	PROPN	NNP	Number=Sing	_	_	_	_
39	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	latency	latency	INTJ	UH	_	_	_	_	_
44	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2689
# text = We have studied the expression of EBV proteins in 17 cases of EBV-positive endemic BL by immunohistology.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	17	17	NUM	CD	NumType=Card	_	_	_	_
11	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	endemic	endemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	BL	Bl	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	immunohistology	immunohistology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2690
# text = Expression of LMP1 was seen in variable proportions of tumor cells in two cases and EBNA2 was detected in some tumor cells in three other cases.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
8	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	EBNA2	Ebna2	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	some	some	DET	DT	_	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	three	three	NUM	CD	NumType=Card	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2691
# text = Also, the BZLF1 trans-activator protein was expressed in a few tumor cells in 6 cases, indicating entry into the lytic cycle.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BZLF1	Bzlf1	NOUN	NN	Number=Sing	_	_	_	_
5	trans-	trans-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2692
# text = A phenotypic drift from latency I to latency III has been observed previously in some BL cell lines.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
3	drift	drift	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	latency	latency	VERB	VB	VerbForm=Inf	_	_	_	_
9	III	III	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	some	some	DET	DT	_	_	_	_	_
16	BL	Bl	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2693
# text = Our results suggest that a similar phenomenon may occur in BL in vivo and indicate that the operational definition of EBV latencies is not easily applied to human tumors.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	BL	BL	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	operational	operational	ADJ	JJ	Degree=Pos	_	_	_	_
19	definition	definition	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
22	latencies	latency	NOUN	NNS	Number=Plur	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	easily	easily	ADV	RB	_	_	_	_	_
26	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2694
# text = Document 003003298 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003298	003003298	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2695
# text = Expression of erythroid-specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
9	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
13	myeloproliferative	myeloproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
14	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Down	Down	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	's	's	PART	POS	_	_	_	_	_
18	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2696
# text = Acute megakaryoblastic leukaemia (M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	M7	M7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloproliferative	myeloproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
10	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Down	Down	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	's	's	PART	POS	_	_	_	_	_
14	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
25	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2697
# text = To clarify properties of the blast cells in M7 and TMD cases, we examined erythroid markers expression in blasts from six cases with M7 and seven cases with TMD in this study.
1	To	to	PART	TO	_	_	_	_	_
2	clarify	clarify	VERB	VB	VerbForm=Inf	_	_	_	_
3	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	M7	M7	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	six	six	NUM	CD	NumType=Card	_	_	_	_
23	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	M7	M7	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	seven	seven	NUM	CD	NumType=Card	_	_	_	_
28	cases	casis	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2698
# text = Erythroid-specific mRNAs encoding gamma-globin and erythroid delta-aminolevulinate synthase were found to be expressed in blasts from most of these cases, indicating that majorities of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes.
1	Erythroid	Erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
5	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	delta-	delta-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	aminolevulinate	aminolevulinate	ADJ	JJ	Degree=Pos	_	_	_	_
13	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	majorities	majoritie	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	M7	M7	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
37	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
38	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	erythroid	erythroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
42	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2699
# text = We also found that mRNAs encoding GATA-1 and GATA-2 are expressed in all these cases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mRNAs	mRNAs	PROPN	NNPS	Number=Plur	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	all	all	DET	PDT	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2700
# text = These results suggest that M7 blasts and TMD blasts correspond to the erythroid/megakaryocytic bipotential progenitor cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	M7	M7	NUM	CD	NumType=Card	_	_	_	_
6	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
9	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
10	correspond	correspond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	bipotential	bipotential	ADJ	JJ	Degree=Pos	_	_	_	_
17	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2701
# text = Document 003003299 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003299	003003299	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2702
# text = Growth regulation and cellular changes during differentiation of human prostatic cancer LNCaP cells as induced by T lymphocyte-conditioned medium.
1	Growth	growth	NOUN	NN	Number=Sing	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
12	LNCaP	Lncap	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2703
# text = Human prostatic epithelial cells from an androgen-dependent LNCaP cell line were examined in response to conditioned medium (CM) derived from phytohemagglutinin (PHA)-stimulated lymphocytes.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	LNCaP	Lncap	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CM	cm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2704
# text = Addition of CM caused a greater than 70% reduction of cell proliferation by cell counting and cell cycle.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CM	cm	PROPN	NNP	Number=Sing	_	_	_	_
4	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
7	than	than	ADP	IN	_	_	_	_	_
8	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	%	%	SYM	NN	Number=Sing	_	_	_	_
10	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	counting	counting	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2705
# text = These cells showed G1 phase arrest and the clonogenicity was reduced.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	G1	G1	NUM	CD	NumType=Card	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
6	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	clonogenicity	clonogenicity	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2706
# text = The growth-modulating effect was dose-dependent and not due to cell lysis or apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	modulating	modulating	NOUN	NN	Number=Sing	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	due	due	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
15	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2707
# text = The binding of androgen to androgen receptor on these cells showed approximately 50% reduction, underlining a proliferation reduction mechanism.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	androgen	androgen	VERB	VB	VerbForm=Inf	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	underlining	underlin	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2708
# text = The prostate-specific antigen (PSA) was downregulated to approximately 75% during the process.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	prostate	prostate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PSA	PSa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2709
# text = Cell morphology showed dendritic processes extending from cytoplasm and other neuroendocrine cell characteristics.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
5	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
6	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	neuroendocrine	neuroendocrine	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2710
# text = The expression of several cytoskeleton and intracellular proteins increased as determined by immunostaining on slides and by ELISA procedures.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytoskeleton	cytoskeleton	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	immunostaining	immunostain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	slides	slide	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
19	procedures	procedure	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2711
# text = These included vimentin, correlating to cell shape changes, cytokeratins 8 and 18, associated with differentiated cell types of prostate epithelia, and neuron-specific enolase and serotonin, associated with neuroendocrine cells.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	vimentin	vimentin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	correlating	correlat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
8	shape	shape	NOUN	NN	Number=Sing	_	_	_	_
9	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	cytokeratins	cytokeratin	NOUN	NNS	Number=Plur	_	_	_	_
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	types	type	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	prostate	prostate	NOUN	NN	Number=Sing	_	_	_	_
23	epithelia	epithelia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	neuron	neuron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	enolase	enolase	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	serotonin	serotonin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	neuroendocrine	neuroendocrine	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2712
# text = From these cellular changes, we can infer that the cell growth was modulated along with induction of terminal differentiation.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	infer	infer	VERB	VB	VerbForm=Inf	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	along	along	ADP	IN	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2713
# text = Activated T cells were demonstrated to be important in providing the modulating activity.
1	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	modulating	modulating	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2714
# text = This growth modulator was semipurified and had an estimated molecular weight 13,000 to 24,000 Da.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	semipurified	semipurify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	had	have	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	estimated	estimate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	molecular	molecular	NOUN	NN	Number=Sing	_	_	_	_
11	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
12	13,000	13,000	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	24,000	24,000	NUM	CD	NumType=Card	_	_	_	_
15	Da	da	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2715
# text = The activity was determined to be distinct from TGF, TNF, and some commonly known lymphokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	determined	determine	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	some	some	DET	DT	_	_	_	_	_
15	commonly	commonly	ADV	RB	_	_	_	_	_
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	lymphokines	lymphokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2716
# text = The interaction between lymphoid and prostatic cells in growth and development is described.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	development	development	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2717
# text = Document 003003300 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003300	003003300	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2718
# text = Two distinct forms of active transcription factor CREB (cAMP response element binding protein).
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2719
# text = Mammalian cells express two distinct forms of transcription factor CREB (cAMP response element binding protein) that are apparently the products of alternative splicing of the CREB gene transcript.
1	Mammalian	Mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	apparently	apparently	ADV	RB	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	products	product	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
25	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2720
# text = The two proteins differ by a 14-amino acid serine-rich insertion present in one of the CREB isoforms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
11	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
14	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
15	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
21	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2721
# text = We show that both CREB isoforms are expressed in many cell types and mammalian species.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
6	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2722
# text = Both encode proteins that bind specifically to a cAMP response element in vitro.
1	Both	both	DET	DT	_	_	_	_	_
2	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specifically	specifically	ADV	RB	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2723
# text = As expected for proteins of this class, the CREB proteins bind DNA as dimers.
1	As	as	SCONJ	IN	_	_	_	_	_
2	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CREB	CREB	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	bind	bind	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2724
# text = Both proteins impart cAMP-regulated transcriptional activity to a heterologous DNA-binding domain, showing that cAMP directly modulates the transcriptional stimulatory activity of CREB.
1	Both	both	DET	DT	_	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	impart	impart	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
20	directly	directly	ADV	RB	_	_	_	_	_
21	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2725
# text = The presence of multiple CREB isoforms with identical DNA-binding specificities but differences in the presumed regulatory domain raises the possibility that CREB proteins may be able to integrate distinct regulatory signals at the level of gene transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
6	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	raises	raise	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
25	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	integrate	integrate	VERB	VB	VerbForm=Inf	_	_	_	_
31	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	level	level	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2726
# text = Document 003003302 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003302	003003302	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2727
# text = Transcription factors as targets for oxidative signalling during lymphocyte activation.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	as	as	ADP	IN	_	_	_	_	_
4	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
7	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2728
# text = We previously have demonstrated a requirement for oxidative events during cell cycle entry in T lymphocytes and have hypothesised that reactive oxygen species may act as intracellular signalling agents during lymphocyte activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
13	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	hypothesised	hypothesise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
23	species	species	NOUN	NNS	Number=Plur	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
28	signalling	signall	NOUN	NN	Number=Sing	_	_	_	_
29	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
30	during	during	ADP	IN	_	_	_	_	_
31	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2729
# text = In the current study, cysteamine, an aminothiol compound with antioxidant activity, has been used to further investigate the role of oxidative signalling during lymphocyte activation.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	aminothiol	aminothiol	ADJ	JJ	Degree=Pos	_	_	_	_
10	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	further	further	ADV	RB	_	_	_	_	_
20	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
25	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
26	during	during	ADP	IN	_	_	_	_	_
27	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2730
# text = Treatment of normal human peripheral blood lymphocytes with cysteamine in vitro was found to inhibit proliferation in a dose-dependent manner, with essentially complete inhibition occurring at a dose of 400 microM.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	essentially	essentially	ADV	RB	_	_	_	_	_
26	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
27	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
28	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	400	400	NUM	CD	NumType=Card	_	_	_	_
34	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2731
# text = This inhibitory effect was limited to the first 2 h after mitogenic activation, localizing the time-frame of action of cysteamine to within the commitment period.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	limited	limit	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	h	h	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	localizing	localize	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	action	action	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
28	period	period	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2732
# text = It therefore was of interest to establish which, if any, commitment events were affected by oxidative signalling during cell cycle entry.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interest	interest	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
8	which	which	PRON	WDT	PronType=Int	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	if	if	SCONJ	IN	_	_	_	_	_
11	any	any	DET	DT	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
19	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
23	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2733
# text = Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation, and on the activity of transcription factors AP-1, NF-kappa B, NF-AT and Oct1, whose functions are required for expression of the IL-2 mRNA.
1	Taking	take	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	Oct1	Oct1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
49	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
50	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
51	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	for	for	ADP	IN	_	_	_	_	_
53	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	2	2	NUM	CD	NumType=Card	_	_	_	_
59	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2734
# text = Cysteamine treatment inhibited both expression of the IL-2 mRNA and secretion of IL-2 into the culture medium.
1	Cysteamine	Cysteamine	ADJ	JJ	Degree=Pos	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
21	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2735
# text = The inhibitory effect of cysteamine may be mediated at least in part by an effect on transcription factor function, as the DNA binding activities of AP-1 and NF-kappa B extracted from mitogen-stimulated cells were significantly inhibited by cysteamine treatment.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADV	RB	_	_	_	_	_
10	least	least	ADV	RBS	Degree=Sup	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	part	part	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	significantly	significantly	ADV	RB	_	_	_	_	_
43	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
46	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2736
# text = Interestingly, Oct1 and NF-AT DNA binding activity were not affected by cysteamine treatment, suggesting that oxidative signalling processes operate in a selective manner.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Oct1	Oct1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
21	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
22	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
23	operate	operate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
27	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2737
# text = The identification of regulatory proteins, such as transcription factors, as molecular targets for oxidative signalling provides further evidence to implicate oxidative signalling as being intimately involved in the G0 to G1 phase transition in T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
14	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
17	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
18	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
20	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	implicate	implicate	VERB	VB	VerbForm=Inf	_	_	_	_
23	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
24	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
27	intimately	intimately	ADV	RB	_	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	G0	G0	PROPN	NNP	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	G1	G1	NUM	CD	NumType=Card	_	_	_	_
34	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
35	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2738
# text = Document 003003303 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003303	003003303	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2739
# text = Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
1	Constitutively	Constitutively	ADV	RB	_	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2740
# text = Human T cell lymphotropic virus I (HTLV-I) is the etiological agent for adult T cell leukemia and tropical spastic paraparesis (also termed HTLV-I-associated myelopathy).
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	etiological	etiological	ADJ	JJ	Degree=Pos	_	_	_	_
15	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	tropical	tropical	ADJ	JJ	Degree=Pos	_	_	_	_
23	spastic	spastic	ADJ	JJ	Degree=Pos	_	_	_	_
24	paraparesis	paraparesis	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	also	also	ADV	RB	_	_	_	_	_
27	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	myelopathy	myelopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2741
# text = HTLV-I-infected peripheral blood T cells exhibit an initial phase of interleukin-2 (IL-2)-dependent growth; over time, by an unknown mechanism, the cells become IL-2-independent.
1	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
7	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	exhibit	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
13	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	over	over	ADP	IN	_	_	_	_	_
28	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
33	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	independent.	independent	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2742
# text = Whereas the Jak kinases Jak1 and Jak3 and the signal transducer and activator of transcription proteins Stat3 and Stat5 are activated in normal T cells in response to IL-2, this signaling pathway was constitutively activated in HTLV-I-transformed cells.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
4	kinases	kinase	PROPN	NNPS	Number=Plur	_	_	_	_
5	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
35	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	constitutively	constitutively	ADV	RB	_	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2743
# text = In HTLV-I-infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation.
1	In	in	ADP	IN	_	_	_	_	_
2	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	acquisition	acquisition	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	constitutively	constitutively	ADV	RB	_	_	_	_	_
33	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
37	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
44	participates	participate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	I-	I-	SYM	SYM	_	_	_	_	SpaceAfter=No
49	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	T	t	PROPN	NNP	Number=Sing	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2744
# text = Document 003003306 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003306	003003306	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2745
# text = Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	CD43/leukosialin-	Cd43/leukosialin-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2746
# text = The monoclonal antibody (mAb) J393 induces apoptosis in Jurkat T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
3	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	J393	J393	NUM	CD	NumType=Card	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2747
# text = NH2-terminal amino acid sequence analysis identified the 140-kDa surface antigen for mAb J393 as CD43/leukosialin, the major sialoglycoprotein of leukocytes.
1	NH2	NH2	X	LS	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
4	amino	amino	DET	DT	_	_	_	_	_
5	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	140	140	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
17	J393	J393	NUM	CD	NumType=Card	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	CD43	CD43	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	leukosialin	leukosialin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
25	sialoglycoprotein	sialoglycoprotein	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2748
# text = While Jurkat cells co-expressed two discrete cell-surface isoforms of CD43, recognized by mAb J393 and mAb G10-2, respectively, only J393/CD43 signaled apoptosis.
1	While	while	SCONJ	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	co-expressed	co-express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-surface	-surface	NOUN	NN	Number=Sing	_	_	_	_
9	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD43	CD43	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
16	J393	J393	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
19	G10	G10	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	only	only	ADV	RB	_	_	_	_	_
26	J393/CD43	J393/CD43	NUM	CD	NumType=Card	_	_	_	_
27	signaled	signale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2749
# text = J393/CD43 was found to be hyposialylated, bearing predominantly O-linked monosaccharide glycans, whereas G10-2/CD43 bore complex sialylated tetra- and hexasaccharide chains.
1	J393/CD43	J393/CD43	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	hyposialylated	hyposialylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
9	predominantly	predominantly	ADV	RB	_	_	_	_	_
10	O-	O-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	monosaccharide	monosaccharide	NOUN	NN	Number=Sing	_	_	_	_
13	glycans	glycan	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	G10-2/CD43	G10-2/CD43	NUM	CD	NumType=Card	_	_	_	_
17	bore	bore	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	SYM	SYM	_	_	_	_	_
19	sialylated	sialylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	tetra	tetra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	hexasaccharide	hexasaccharide	NOUN	NN	Number=Sing	_	_	_	_
24	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2750
# text = Treatment with soluble, bivalent mAb J393 killed 25-50% of the cell population, while concomitant engagement of either the CD3.TcR complex or the integrins CD18 and CD29 significantly potentiated this effect.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	bivalent	bivalent	ADJ	JJ	Degree=Pos	_	_	_	_
6	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
7	J393	J393	NUM	CD	NumType=Card	_	_	_	_
8	killed	kill	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	%	%	SYM	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
20	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	either	either	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	CD3.TcR	Cd3.tcr	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	integrins	integrin	PROPN	NNPS	Number=Plur	_	_	_	_
29	CD18	CD18	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CD29	CD29	PROPN	NNP	Number=Sing	_	_	_	_
32	significantly	significantly	ADV	RB	_	_	_	_	_
33	potentiated	potentiate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2751
# text = Treatment of Jurkat cells with mAb J393 induced tyrosine phosphorylation of specific protein substrates that underwent hyperphosphorylation upon antigen receptor costimulation.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
7	J393	J393	NUM	CD	NumType=Card	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	substrates	substrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
17	hyperphosphorylation	hyperphosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	upon	upon	ADP	IN	_	_	_	_	_
19	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2752
# text = Tyrosine kinase inhibition by herbimycin A diminished J393/CD43-mediated apoptosis, whereas inhibition of phosphotyrosine phosphatase activity by bis(maltolato)oxovanadium-IV enhanced cell death.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	J393/CD43	J393/CD43	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	phosphotyrosine	phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	bis	bis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	maltolato	maltolato	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	oxovanadium	oxovanadium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	IV	iv	NOUN	NN	Number=Sing	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2753
# text = Signal transduction through tyrosine kinase activation may lead to altered gene expression, as J393/CD43 ligation prompted decreases in the nuclear localization of the transcriptional regulatory protein NF-kappaB and proteins binding the interferon-inducible regulatory element.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	J393/CD43	J393/CD43	NUM	CD	NumType=Card	_	_	_	_
16	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
17	prompted	prompt	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
38	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
39	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2754
# text = Since peripheral blood T-lymphocytes express cryptic epitopes for mAb J393, these findings demonstrate the existence of a tightly regulated CD43-mediated pathway for inducing apoptosis in human T-cell lineages.
1	Since	since	ADP	IN	_	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
7	cryptic	cryptic	ADJ	JJ	Degree=Pos	_	_	_	_
8	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
11	J393	J393	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
15	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	tightly	tightly	ADV	RB	_	_	_	_	_
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	CD43	CD43	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2755
# text = Document 003003307 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003307	003003307	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2756
# text = 1,25-Dihydroxyvitamin D3 induces differentiation of a retinoic acid-resistant acute promyelocytic leukemia cell line (UF-1) associated with expression of p21(WAF1/CIP1) and p27(KIP1).
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Dihydroxyvitamin	Dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
4	D3	D3	NUM	CD	NumType=Card	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
13	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
14	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	WAF1/CIP1	WAF1/CIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	KIP1	KIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2757
# text = Retinoic acid (RA) resistance is a serious problem for patients with acute promyelocytic leukemia (APL) who are receiving all-trans RA.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	serious	serious	ADJ	JJ	Degree=Pos	_	_	_	_
10	problem	problem	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	APL	APL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	who	who	PRON	WP	PronType=Rel	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
23	all	all	DET	DT	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
26	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2758
# text = However, the mechanisms and strategies to overcome RA resistance by APL cells are still unclear.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
10	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	still	still	ADV	RB	_	_	_	_	_
16	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2759
# text = The biologic effects of RA are mediated by two distinct families of transcriptional factors:
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	biologic	biologic	NOUN	NN	Number=Sing	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	families	family	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2760
# text = RA receptors (RARs) and retinoid X receptors (RXRs).
1	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
2	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	retinoid	retinoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	X	x	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RXRs	RXR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2761
# text = RXRs heterodimerize with 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3] receptor (VDR), enabling their efficient transcriptional activation.
1	RXRs	RXR	NOUN	NNS	Number=Plur	_	_	_	_
2	heterodimerize	heterodimerize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
9	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
10	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	]	]	PUNCT	-RRB-	_	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	enabling	enable	VERB	VBG	VerbForm=Ger	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2762
# text = The cyclin-dependent kinase (cdk) inhibitor p21(WAF1/CIP1) has a vitamin D3-responsive element (VDRE) in its promoter, and 1,25(OH)2D3 enhances the expression of p21(WAF1/CIP1) and induces differentiation of selected myeloid leukemic cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	cdk	cdk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	WAF1/CIP1	Waf1/cip1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
17	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	VDRE	VDRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
34	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	p21	p21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	WAF1/CIP1	Waf1/cip1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
44	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	selected	selected	ADJ	JJ	Degree=Pos	_	_	_	_
47	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
48	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2763
# text = We have recently established a novel APL cell line (UF-1) with features of RA resistance.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	APL	Apl	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	X	LS	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
19	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2764
# text = 1,25(OH)2D3 can induce growth inhibition and G1 arrest of UF-1 cells, resulting in differentiation of these cells toward granulocytes.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	G1	G1	NUM	CD	NumType=Card	_	_	_	_
12	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	toward	toward	ADP	IN	_	_	_	_	_
26	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2765
# text = This 1, 25(OH)2D3-induced G1 arrest is enhanced by all-trans RA.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
12	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
19	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2766
# text = Also, 1, 25(OH)2D3 (10(-10) to 10(-7) mol/L) in combination with RA markedly inhibits cellular proliferation in a dose- and time-dependent manner.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(-10	(-10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
17	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
25	markedly	markedly	ADV	RB	_	_	_	_	_
26	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2767
# text = Associated with these findings, the levels of p21(WAF1/CIP1) and p27(KIP1) mRNA and protein increased in these cells.
1	Associated	Associated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	findings	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	WAF1/CIP1	WAF1/CIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2768
# text = Northern blot analysis showed that p21(WAF1/CIP1) and p27(KIP1) mRNA and protein increased in these cells.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	WAF1/CIP1	WAF1/CIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2769
# text = Northern blot analysis showed that p21(WAF1/CIP1) and p27(KIP1) transcripts were induced after 6 hours' exposure to 1,25(OH)2D3 and then decreased to basal levels over 48 hours.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	WAF1/CIP1	WAF1/CIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	'	's	PART	POS	_	_	_	_	_
22	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	then	then	ADV	RB	PronType=Dem	_	_	_	_
31	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	over	over	ADP	IN	_	_	_	_	_
36	48	48	NUM	CD	NumType=Card	_	_	_	_
37	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2770
# text = Western blot experiments showed that p21(WAF1/CIP1) protein levels increased and became detectable after 12 hours of 1,25(OH)2D3 treatment and induction of p27(KIP1) protein was much more gradual and sustained in UF-1 cells.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	WAF1/CIP1	WAF1/CIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	became	become	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	12	12	NUM	CD	NumType=Card	_	_	_	_
18	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
25	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	much	much	ADV	RB	_	_	_	_	_
36	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
37	gradual	gradual	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	sustained	sustain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2771
# text = Interestingly, the combination of 1, 25(OH)2D3 and RA markedly enhanced the levels of p27(KIP1) transcript and protein as compared with levels induced by 1, 25(OH)2D3 alone.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
15	markedly	markedly	ADV	RB	_	_	_	_	_
16	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	as	as	SCONJ	IN	_	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
40	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2772
# text = In addition, exogenous p27(KIP1) expression can enhance the level of CD11b antigen in myeloid leukemic cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
5	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	b	b	NOUN	NN	Number=Sing	_	_	_	_
18	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2773
# text = In contrast, RA alone can induce G1 arrest of UF-1 cells; however, it did not result in an increase of p21(WAF1/CIP1) and p27(KIP1) transcript and protein expression in RA-resistant cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
5	alone	alone	ADV	RB	_	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
8	G1	G1	NUM	CD	NumType=Card	_	_	_	_
9	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	WAF1/CIP1	Waf1/cip1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	p27(	p27(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	KIP1	KIP1	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2774
# text = Taken together, we conclude that 1,25(OH)2D3 induces increased expression of cdk inhibitors, which mediates a G1 arrest, and this may be associated with differentiation of RA-resistant UF-1 cells toward mature granulocytes.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
12	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cdk	cdk	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	G1	G1	NUM	CD	NumType=Card	_	_	_	_
23	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
36	UF	Uf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	toward	toward	ADP	IN	_	_	_	_	_
41	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
42	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2775
# text = Document 003003314 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003314	003003314	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2776
# text = Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	Cryptococcus	Cryptococcus	PROPN	NNP	Number=Sing	_	_	_	_
15	neoformans	neoforman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Candida	Candida	PROPN	NNP	Number=Sing	_	_	_	_
18	albicans	albican	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2777
# text = Deactivation of mononuclear phagocytes is critical to limit the inflammatory response but can be detrimental in the face of progressive infection.
1	Deactivation	Deactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	limit	limit	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	detrimental	detrimental	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	face	face	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
21	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2778
# text = We compared the effects of the deactivating cytokine interleukin 10 (IL-10) on human peripheral blood mononuclear cell (PBMC) responses to lipopolysaccharide (LPS), Cryptococcus neoformans, and Candida albicans.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	deactivating	deactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	LPS	Lp	INTJ	UH	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	Cryptococcus	Cryptococcus	PROPN	NNP	Number=Sing	_	_	_	_
33	neoformans	neoforman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Candida	Candida	PROPN	NNP	Number=Sing	_	_	_	_
37	albicans	albicans	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2779
# text = IL-10 effected dose-dependent inhibition of tumor necrosis factor alpha (TNF-alpha) release in PBMC stimulated by LPS and C. neoformans, with significant inhibition seen with 0.1
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	effected	effect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	release	release	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
27	neoformans	neoforman	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
31	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
32	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	0.1	0.1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2780
# text = U/ml and greater than 90% inhibition noted with 10 U/ml.
1	U/	U/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
5	than	than	ADP	IN	_	_	_	_	_
6	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	%	%	SYM	NN	Number=Sing	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	noted	note	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	10	10	NUM	CD	NumType=Card	_	_	_	_
12	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2781
# text = In contrast, even at doses as high as 100 U/ml, IL-10 inhibited TNF-alpha release in response to C. albicans by only 50%.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	even	even	ADV	RB	_	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	100	100	NUM	CD	NumType=Card	_	_	_	_
11	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	release	release	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
26	albicans	albicans	PROPN	NNPS	Number=Plur	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	50%	50%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2782
# text = IL-10 profoundly inhibited release of IL-1beta from PBMC stimulated by all three stimuli.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	profoundly	profoundly	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	release	release	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	three	three	NUM	CD	NumType=Card	_	_	_	_
18	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2783
# text = TNF-alpha mRNA and release was inhibited even if IL-10 was added up to 8 h after cryptococcal stimulation.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	release	release	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	even	even	ADV	RB	_	_	_	_	_
10	if	if	SCONJ	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	up	up	ADP	RP	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	8	8	NUM	CD	NumType=Card	_	_	_	_
19	h	h	NOUN	NN	Number=Sing	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	cryptococcal	cryptococcal	ADJ	JJ	Degree=Pos	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2784
# text = In contrast, inhibition of IL-1 beta mRNA was of lesser magnitude and occurred only when IL-10 was added within 2 h of cryptococcal stimulation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
14	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	only	only	ADV	RB	_	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	IL	IL	SYM	$	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	10	10	NUM	CD	NumType=Card	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	within	within	ADP	IN	_	_	_	_	_
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	h	h	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cryptococcal	cryptococcal	ADJ	JJ	Degree=Pos	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2785
# text = IL-10 inhibited translocation of NF-kappaB in response to LPS but not the fungal stimuli.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	fungal	fungal	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2786
# text = All three stimuli induced IL-10 production in PBMC, although over 10-fold less IL-10 was released in response to C. neoformans compared with LPS and C.
1	All	all	DET	DT	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	although	although	SCONJ	IN	_	_	_	_	_
13	over	over	ADP	IN	_	_	_	_	_
14	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
17	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	released	release	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
27	neoformans	neoforman	NOUN	NNS	Number=Plur	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2787
# text = albicans.
1	albicans	albican	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2788
# text = Thus, while IL-10 has deactivating effects on PBMC responses to all three stimuli, disparate stimulus- and response-specific patterns of deactivation are seen.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	deactivating	deactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	all	all	DET	DT	_	_	_	_	_
15	three	three	NUM	CD	NumType=Card	_	_	_	_
16	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	disparate	disparate	ADJ	JJ	Degree=Pos	_	_	_	_
19	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	deactivation	deactivation	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2789
# text = Inhibition by IL-10 of proinflammatory cytokine release appears to occur at the level of gene transcription for TNF-alpha and both transcriptionally and posttranscriptionally for IL-1beta.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	release	release	NOUN	NN	Number=Sing	_	_	_	_
10	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	both	both	CCONJ	CC	_	_	_	_	_
25	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	posttranscriptionally	posttranscriptionally	ADV	RB	_	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2790
# text = Document 003003316 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003316	003003316	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2791
# text = The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
3	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	restricts	restrict	NOUN	NNS	Number=Plur	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	along	along	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
18	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2792
# text = We have isolated cDNA clones of myeloid differentiation primary response (MyD) genes, activated in the absence of de novo protein synthesis following induction for differentiation along either the macrophage or granulocyte lineage in human myeloblastic leukemia HL-60 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MyD	myd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	de	de	PROPN	NNP	Number=Sing	_	_	_	_
22	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
25	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	along	along	ADP	IN	_	_	_	_	_
30	either	either	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
35	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	myeloblastic	myeloblastic	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
40	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	60	60	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2793
# text = One cDNA clone of a primary response gene, expressed upon macrophage differentiation, encoded for Egr-1, a zinc finger transcription factor.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	encoded	encode	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
22	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2794
# text = The Egr-1 gene was observed to be transcriptionally silent in HL-60 cells, but active in U-937 and M1 cells, the latter two being predetermined for macrophage differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
10	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	60	60	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	937	937	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	M1	M1	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
31	predetermined	predetermine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2795
# text = Egr-1 antisense oligomers in the culture media blocked macrophage differentiation in both myeloid leukemia cell lines and normal myeloblasts.
1	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	_
3	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
4	oligomers	oligomer	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
8	media	media	NOUN	NN	Number=Sing	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	myeloblasts	myeloblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2796
# text = HL-60 cells constitutively expressing an Egr-1 transgene (HL-60Egr-1) could be induced for macrophage, but not granulocyte, differentiation.
1	HL	Hl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	60	60	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	constitutively	constitutively	ADV	RB	_	_	_	_	_
6	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-1	-1	NUM	CD	NumType=Card	_	_	_	_
10	transgene	transgene	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HL-	HL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	60Egr	60Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2797
# text = These observations indicate that expression of Egr-1 is essential for and restricts differentiation of myeloblasts along the macrophage lineage.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-1	-1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	restricts	restrict	NOUN	NNS	Number=Plur	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	myeloblasts	myeloblast	NOUN	NNS	Number=Plur	_	_	_	_
17	along	along	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2798
# text = Document 003003321 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003321	003003321	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2799
# text = [Glucocorticoid receptors on human peripheral mononuclear and polymorphonuclear leucocytes: changes in patients with yang-deficiency]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Glucocorticoid	Glucocorticoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
7	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	yang	yang	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2800
# text = It was found that, in former works, the glucocorticoid receptors (GCR) on peripheral mixed leucocytes in patients with Yang-deficiency were decreased.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	former	former	ADJ	JJ	Degree=Pos	_	_	_	_
8	works	work	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
19	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	Yang	Yang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2801
# text = In this work, the mixed leucocytes were further separated into mononuclear (MNL) and polymorphonuclear (PML) leucocytes, and GCR were determined in each part of leucocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mixed	mixed	ADJ	JJ	Degree=Pos	_	_	_	_
7	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	further	further	ADV	RB	_	_	_	_	_
10	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	polymorphonuclear	polymorphonuclear	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PML	pMl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	GCR	GCR	ADV	RBR	Degree=Cmp	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	each	each	DET	DT	_	_	_	_	_
29	part	part	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2802
# text = GCR on MNL and PML in 6 Yang deficient patients were 3473 +/- 413 and 4433 +/- 651 sites/cell respectively, statistically significant from the normal control group (4462 +/- 962 and 5622 +/- 782 sites/cell respectively, P less than 0.05).
1	GCR	Gcr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	MNL	MNL	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	PML	PML	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	Yang	Yang	PROPN	NNP	Number=Sing	_	_	_	_
9	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	3473	3473	NUM	CD	NumType=Card	_	_	_	_
13	+/-	+/-	SYM	SYM	_	_	_	_	_
14	413	413	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	4433	4433	NUM	CD	NumType=Card	_	_	_	_
17	+/-	+/-	SYM	SYM	_	_	_	_	_
18	651	651	NUM	CD	NumType=Card	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	statistically	statistically	ADV	RB	_	_	_	_	_
25	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	control	control	NOUN	NN	Number=Sing	_	_	_	_
30	group	group	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	4462	4462	NUM	CD	NumType=Card	_	_	_	_
33	+/-	+/-	SYM	SYM	_	_	_	_	_
34	962	962	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	5622	5622	NUM	CD	NumType=Card	_	_	_	_
37	+/-	+/-	SYM	SYM	_	_	_	_	_
38	782	782	NUM	CD	NumType=Card	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
42	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	P	p	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
45	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
46	than	than	ADP	IN	_	_	_	_	_
47	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2803
# text = GCR on MNL, PML and mixed leucocytes in 5 patients were determined simultaneously, and all lowered from the control group.
1	GCR	Gcr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
8	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	simultaneously	simultaneously	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	all	all	ADV	RB	_	_	_	_	_
18	lowered	lower	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	control	control	NOUN	NN	Number=Sing	_	_	_	_
22	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2804
# text = The results were 3369 +/- 370, 4986 +/- 419 and 4524 +/- 852 sites/cell respectively, with the lowest GCR on MNL and highest on PML.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	3369	3369	NUM	CD	NumType=Card	_	_	_	_
5	+/-	+/-	SYM	SYM	_	_	_	_	_
6	370	370	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	4986	4986	NUM	CD	NumType=Card	_	_	_	_
9	+/-	+/-	SYM	SYM	_	_	_	_	_
10	419	419	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	4524	4524	NUM	CD	NumType=Card	_	_	_	_
13	+/-	+/-	SYM	SYM	_	_	_	_	_
14	852	852	NUM	CD	NumType=Card	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	lowest	lowest	ADJ	JJS	Degree=Sup	_	_	_	_
23	GCR	Gcr	PROPN	NNP	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2805
# text = Document 003003324 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003324	003003324	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2806
# text = p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes.
1	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	integrates	integrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	phosphatidylinositol	phosphatidylinositol	INTJ	UH	_	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	rapamycin-	rapamycin-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	F	F	PROPN	NNP	Number=Sing	_	_	_	_
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2807
# text = In T lymphocytes, the hematopoietic cytokine interleukin-2 (IL-2) uses phosphatidylinositol 3-kinase (PI 3-kinase)-induced signaling pathways to regulate E2F transcriptional activity, a critical cell cycle checkpoint.
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	phosphatidylinositol	phosphatidylinositol	INTJ	UH	_	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	PI	Pi	NUM	CD	NumType=Card	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
30	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
33	E2F	E2F	ADP	RP	_	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
41	checkpoint	checkpoint	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2808
# text = PI 3-kinase also regulates the activity of p70(s6k), the 40S ribosomal protein S6 kinase, a response that is abrogated by the macrolide rapamycin.
1	PI	PI	NOUN	NN	Number=Sing	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	S	's	NOUN	NN	Number=Sing	_	_	_	_
19	ribosomal	ribosomal	ADJ	JJ	Degree=Pos	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	S6	S6	NUM	CD	NumType=Card	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	macrolide	macrolide	ADJ	JJ	Degree=Pos	_	_	_	_
32	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2809
# text = This immunosuppressive drug is known to prevent T-cell proliferation, but the precise point at which rapamycin regulates T-cell cycle progression has yet to be elucidated.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
8	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
15	point	point	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
19	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
23	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	yet	yet	ADV	RB	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2810
# text = Moreover, the effects of rapamycin on, and the role of p70(s6k) in, IL-2 and PI 3-kinase activation of E2Fs have not been characterized.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	PI	PI	NUM	CD	NumType=Card	_	_	_	_
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	Fs	F	NOUN	NNS	Number=Plur	_	_	_	_
32	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2811
# text = Our present results show that IL-2- and PI 3-kinase-induced pathways for the regulation of E2F transcriptional activity include both rapamycin-resistant and rapamycin-sensitive components.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	both	both	CCONJ	CC	_	_	_	_	_
27	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
32	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2812
# text = Expression of a rapamycin-resistant mutant of p70(s6k) in T cells could restore rapamycin-suppressed E2F responses.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rapamycin-	rapamycin-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
17	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
18	rapamycin-	rapamycin-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	F	f	PROPN	NNP	Number=Sing	_	_	_	_
22	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2813
# text = Thus, the rapamycin-controlled processes involved in E2F regulation appear to be mediated by p70(s6k).
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	F	F	PROPN	NNP	Number=Sing	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2814
# text = However, the rapamycin-resistant p70(s6k) could not rescue rapamycin inhibition of T-cell cycle entry, consistent with the involvement of additional, rapamycin-sensitive pathways in the control of T-cell cycle progression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
6	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	rescue	rescue	VERB	VB	VerbForm=Inf	_	_	_	_
14	rapamycin	rapamycin	ADP	IN	_	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
20	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	control	control	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
39	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2815
# text = The present results thus show that p70(s6k) is able to regulate E2F transcriptional activity and provide direct evidence for the first time for a link between IL-2 receptors, PI 3-kinase, and p70(s6k) that regulates a crucial G1 checkpoint in T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	thus	thus	ADV	RB	_	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	E2F	E2F	ADP	RP	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
21	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
22	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
26	time	time	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	link	link	NOUN	NN	Number=Sing	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	PI	pi	NOUN	NN	Number=Sing	_	_	_	_
37	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
39	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	k	k	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	that	that	PRON	WDT	PronType=Rel	_	_	_	_
48	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
51	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
52	checkpoint	checkpoint	NOUN	NN	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2816
# text = Document 003003327 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003327	003003327	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2817
# text = USF/c-Myc enhances, while Yin-Yang 1 suppresses, the promoter activity of CXCR4, a coreceptor for HIV-1 entry.
1	USF/	USF/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
5	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	while	while	SCONJ	IN	_	_	_	_	_
8	Yin	Yin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Yang	Yang	PROPN	NNP	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CXCR4	CXCR4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	coreceptor	coreceptor	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2818
# text = Transcription factors USF1 and USF2 up-regulate gene expression (i.e., HIV-1 long terminal repeats) via interaction with an E box on their target promoters, which is also a binding site for c-Myc.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	USF1	USF1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	USF2	USF2	NUM	CD	NumType=Card	_	_	_	_
6	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	repeats	repeat	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	E	e	NOUN	NN	Number=Sing	_	_	_	_
26	box	box	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	target	target	NOUN	NN	Number=Sing	_	_	_	_
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2819
# text = The c-Myc oncoprotein is important in control of cellular proliferation and differentiation, while Yin-Yang 1 (YY1) has been shown to control the expression of a number of cellular and viral genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
5	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	Yin	Yin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Yang	Yang	PROPN	NNP	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	YY1	yy1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	number	number	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2820
# text = These two proteins physically interact with each other and mutually inhibit their respective biological functions.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	physically	physically	ADV	RB	_	_	_	_	_
5	interact	interact	ADJ	JJ	Degree=Pos	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	each	each	DET	DT	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	mutually	mutually	ADV	RB	_	_	_	_	_
11	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
14	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2821
# text = In this study, we show that USF/c-Myc up-regulates, while YY1 down-regulates the promoter activity of CXCR4, a coreceptor for T cell-tropic HIV-1 entry.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	USF/	USF/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
12	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	YY1	YY1	PRON	NN	Abbr=Yes|Number=Sing	_	_	_	_
18	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	CXCR4	CXCR4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	coreceptor	coreceptor	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	tropic	tropic	ADJ	JJ	Degree=Pos	_	_	_	_
34	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2822
# text = We have identified an E box around -260 and a YY1 binding site around -300 relative to the transcription start site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	E	e	NOUN	NN	Number=Sing	_	_	_	_
6	box	box	NOUN	NN	Number=Sing	_	_	_	_
7	around	around	ADV	RB	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	260	260	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	YY1	yy1	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	around	around	ADV	RB	_	_	_	_	_
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	300	300	NUM	CD	NumType=Card	_	_	_	_
18	relative	relative	ADV	RB	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	start	start	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2823
# text = Mutation of the E box abolished USF/c-Myc- mediated up-regulation of CXCR4 promoter activity, and mutation of the YY1 binding site was associated with unresponsiveness to YY1-mediated inhibition.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	E	e	NOUN	NN	Number=Sing	_	_	_	_
5	box	box	NOUN	NN	Number=Sing	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	USF/	USF/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CXCR4	CXCR4	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	YY1	YY1	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	unresponsiveness	unresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	YY1	YY1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2824
# text = These data suggest that USF/c-Myc and YY1 may play an important role in the HIV-1-replicative cycle, by modulating both the viral fusion/entry process and viral expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	USF/	Usf/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	YY1	yy1	PRON	NN	Abbr=Yes|Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
23	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	by	by	SCONJ	IN	_	_	_	_	_
26	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
33	process	process	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2825
# text = Document 003003329 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003329	003003329	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2826
# text = The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
14	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2827
# text = B enhancer include the product of the c-rel proto-oncogene.
1	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	product	product	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
10	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2828
# text = The transactivator HTLV-I Tax activates the promoter of the gene coding for the interleukin 2 alpha-chain receptor (IL-2R alpha) via a kappa B site that can bind several protein species of the rel family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
3	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	via	via	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
36	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	species	species	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
42	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2829
# text = Tax1 strongly activates the enhancer activity of this motif, in both epithelial HeLa and lymphoid Jurkat cells.
1	Tax1	tax1	PROPN	NNP	Number=Sing	_	_	_	_
2	strongly	strongly	ADV	RB	_	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2830
# text = This activation was not observed in undifferentiated embryocarcinoma F9 cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
8	embryocarcinoma	embryocarcinoma	NOUN	NN	Number=Sing	_	_	_	_
9	F9	F9	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2831
# text = Overexpression of the p50, p65 and Rel proteins in these cells showed that significant activation of the IL-2R alpha kappa B site was observed only with Rel and Rel plus p65.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	p65	p65	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	ADP	IN	_	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
33	plus	plus	ADV	RB	_	_	_	_	_
34	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2832
# text = Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	whereas	whereas	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
11	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	efficiently	efficiently	ADV	RB	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	functionally	functionally	ADV	RB	_	_	_	_	_
42	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2833
# text = Using the DNA affinity precipitation assay, we observed that Tax1 is able to efficiently induce the binding of Rel, whereas PMA is not.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
5	precipitation	precipitation	NOUN	NN	Number=Sing	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	Tax1	Tax1	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	efficiently	efficiently	ADV	RB	_	_	_	_	_
16	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	whereas	SCONJ	IN	_	_	_	_	_
23	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2834
# text = This established a clear difference between both stimuli, indicating that Rel is the functionally active factor.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	established	establish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
5	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	functionally	functionally	ADV	RB	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2835
# text = We conclude from these results that the functional activity of members of the rel family is regulated by their interaction with DNA and that Rel can be a potent transcriptional activator on specific kappa B sites.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	members	member	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
26	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2836
# text = Document 003003330 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003330	003003330	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2837
# text = Phenotypic and functional studies of leukocytes in human endometrium and endometriosis.
1	Phenotypic	Phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2838
# text = The aetiology of endometriosis, a common and disabling disorder, is presently unknown, although immune dysfunction could allow ectopic endometrial fragments to survive outside the uterine cavity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aetiology	aetiology	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	disabling	disabl	ADJ	JJ	Degree=Pos	_	_	_	_
10	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	presently	presently	ADV	RB	_	_	_	_	_
14	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	although	although	SCONJ	IN	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	dysfunction	dysfunction	NOUN	NN	Number=Sing	_	_	_	_
19	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
20	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
21	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
22	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
23	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	_
26	outside	outside	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	uterine	uterine	NOUN	NN	Number=Sing	_	_	_	_
29	cavity	cavity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2839
# text = These studies investigate the relationship between leukocyte populations, steroid hormone receptor expression, proliferative activity, bcl-2 expression and apoptosis in eutopic and ectopic endometrium from women with endometriosis or adenomyosis at different phases of the menstrual cycle.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
8	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
28	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	adenomyosis	adenomyosis	NOUN	NN	Number=Sing	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
37	phases	phasis	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	menstrual	menstrual	ADJ	JJ	Degree=Pos	_	_	_	_
41	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2840
# text = Significantly increased oestrogen receptor expression, bcl-2 expression and numbers of CD8+ leukocytes were found in ectopic compared with eutopic endometrium in endometriosis, and CD56+ endometrial granulated lymphocytes (eGLs) were significantly reduced in ectopic endometrium.
1	Significantly	significantly	ADV	RB	_	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	oestrogen	oestrogen	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
21	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
24	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	CD56	CD56	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	+	+	SYM	SYM	_	_	_	_	_
31	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
32	granulated	granulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	significantly	significantly	ADV	RB	_	_	_	_	_
39	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
42	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2841
# text = Apoptotic cells were rarely found in control and subject endometria.
1	Apoptotic	Apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	rarely	rarely	ADV	RB	_	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
10	endometria	endometria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2842
# text = In contrast with endometriosis, adenomyotic lesions showed identical steroid hormone receptor expression, proliferative activity, bcl-2 expression and leukocyte subpopulations to eutopic endometrium, indicating different aetiologies for these disorders.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	adenomyotic	adenomyotic	ADJ	JJ	Degree=Pos	_	_	_	_
7	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
11	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
24	subpopulations	subpopulation	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
27	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	aetiologies	aetiology	NOUN	NNS	Number=Plur	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2843
# text = The unusual CD56+ CD16- eGLs present in large numbers in late secretory phase eutopic endometrium were highly purified (>98%) by immunomagnetic separation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	unusual	unusual	ADJ	JJ	Degree=Pos	_	_	_	_
3	CD56	CD56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	_
5	CD16	CD16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	_
7	eGLs	eGLs	NOUN	NNS	Number=Plur	_	_	_	_
8	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
11	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
14	secretory	secretory	ADJ	JJ	Degree=Pos	_	_	_	_
15	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
16	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
17	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	highly	highly	ADV	RB	_	_	_	_	_
20	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	>98	>98	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	immunomagnetic	immunomagnetic	ADJ	JJ	Degree=Pos	_	_	_	_
27	separation	separation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2844
# text = Except for a negligible cytotoxic activity of eGLs from early proliferative samples, cytotoxic activity of eGLs from non-pregnant endometrium during the menstrual cycle was comparable with those in peripheral blood, predominantly CD56+ CD16+ natural killer cells.
1	Except	except	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	negligible	negligible	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	non-pregnant	non-pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
20	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	menstrual	menstrual	ADJ	JJ	Degree=Pos	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
31	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	predominantly	predominantly	ADV	RB	_	_	_	_	_
34	CD56	CD56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	+	+	SYM	SYM	_	_	_	_	_
36	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	+	+	SYM	SYM	_	_	_	_	_
39	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
40	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2845
# text = eGLs from non-pregnant endometrium and early pregnancy showed a variable proliferative response to 5 and 100 U/ml interleukin-2 over 48-h and 120-h time courses.
1	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	non-pregnant	non-pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
4	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	100	100	NUM	CD	NumType=Card	_	_	_	_
17	U/	Uith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
19	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	over	over	ADP	IN	_	_	_	_	_
23	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	h	h	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	120	120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	h	h	NOUN	NN	Number=Sing	_	_	_	_
30	time	time	NOUN	NN	Number=Sing	_	_	_	_
31	courses	course	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2846
# text = eGLs are evidently functionally important in the eutopic endometrium.
1	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidently	evidently	ADV	RB	_	_	_	_	_
4	functionally	functionally	ADV	RB	_	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
9	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2847
# text = Their absence in endometriotic lesions together with increased CD+8 T-cell numbers and increased oestrogen receptor and bcl-2 expression may have significant effects on the development and progression of endometriosis.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	endometriotic	endometriotic	ADJ	JJ	Degree=Pos	_	_	_	_
5	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
6	together	together	ADV	RB	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
11	8	8	NUM	CD	NumType=Card	_	_	_	_
12	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	oestrogen	oestrogen	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
26	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	development	development	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2848
# text = Document 003003333 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003333	003003333	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2849
# text = Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
7	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2850
# text = Cytokine effects on immunity and inflammation often depend on the transcription factors termed signal transducers and activators of transcription (STATs), so STAT signaling pathways are candidates for influencing inflammatory disease.
1	Cytokine	Cytokine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
7	often	often	ADV	RB	_	_	_	_	_
8	depend	depend	VERB	VB	Typo=Yes|VerbForm=Inf	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
15	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	STATs	STATs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	so	so	ADV	RB	_	_	_	_	_
25	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
26	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
27	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	candidates	candidate	NOUN	NNS	Number=Plur	_	_	_	_
30	for	for	SCONJ	IN	_	_	_	_	_
31	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
32	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2851
# text = We reasoned that selective IFN responsiveness of the first STAT family member (Stat1) and Stat1-dependent immune-response genes such as intercellular adhesion molecule-1 (ICAM-1), IFN regulatory factor-1 (IRF-1), and Stat1 itself in airway epithelial cells provides a basis for detecting cytokine signaling abnormalities in inflammatory airway disease.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	reasoned	reason	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
6	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	member	member	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
28	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
38	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-1	-1	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
49	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	airway	airway	ADJ	JJ	Degree=Pos	_	_	_	_
52	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	provides	provides	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
55	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
56	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
57	for	for	SCONJ	IN	_	_	_	_	_
58	detecting	detect	VERB	VBG	VerbForm=Ger	_	_	_	_
59	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
60	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
61	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
64	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
65	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2852
# text = On the basis of nuclear localization and phosphorylation, we found that epithelial Stat1 (but not other control transcription factors) was invariably activated in asthmatic compared with normal control or chronic bronchitis subjects.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	Stat1	Stat1	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	ADV	RB	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	invariably	invariably	ADV	RB	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	asthmatic	asthmatic	ADJ	JJ	Degree=Pos	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	control	control	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
34	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	_
35	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2853
# text = Furthermore, epithelial levels of activated Stat1 correlated with levels of expression for epithelial ICAM-1, IRF-1, and Stat1, and in turn, ICAM-1 levels correlated with T-cell accumulation in tissue.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
8	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
34	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2854
# text = However, only low levels of IFN-gamma or IFN-gamma-producing cells were detected in airway tissue in all subjects.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	producing	producing	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
20	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	all	all	DET	DT	_	_	_	_	_
23	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2855
# text = The results therefore provide initial evidence linking abnormal behavior of STAT pathways for cytokine signaling to the development of an inflammatory disease.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
8	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
9	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	development	development	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2856
# text = In that context, the results also change the current scheme for asthma pathogenesis to one that must include a localized gain in transcriptional signal ordinarily used for a T helper 1-type cytokine (IFN-gamma) in combination with allergy-driven overproduction of T helper 2-type cytokines.
1	In	in	ADP	IN	_	_	_	_	_
2	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	change	change	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
11	scheme	scheme	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
14	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
19	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	gain	gain	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	ordinarily	ordinarily	ADV	RB	_	_	_	_	_
27	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	type	type	NOUN	NN	Number=Sing	_	_	_	_
35	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	allergy	allergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	overproduction	overproduction	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	T	T	PROPN	NNP	Number=Sing	_	_	_	_
50	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
51	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	type	type	NOUN	NN	Number=Sing	_	_	_	_
54	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2857
# text = Document 003003335 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003335	003003335	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2858
# text = Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells).
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Akt	Akt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	phosphatidylinositol	phosphatidylinositol	INTJ	UH	_	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	EPO	EPO	INTJ	UH	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HCD57	HCD57	NUM	CD	NumType=Card	_	_	_	_
26	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	constitutively	constitutively	ADV	RB	_	_	_	_	_
31	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	apoptosis	apoptosis	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
41	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	HCD57-	HCD57-	SYM	SYM	_	_	_	_	SpaceAfter=No
44	SREI	Srei	NUM	CD	NumType=Card	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2859
# text = We found that erythropoietin (EPO) and stem cell factor (SCF) activated protein kinase B (PKB/Akt) in EPO-dependent HCD57 erythroid cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	SCF	SCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	HCD57	HCD57	NUM	CD	NumType=Card	_	_	_	_
29	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2860
# text = To better understand signals controlling proliferation and viability, erythroid cells that resist apoptosis in the absence of EPO were subcloned and characterized (HCD57-SREI cells).
1	To	to	ADP	IN	_	_	_	_	_
2	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
3	understand	understand	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	viability	viability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	resist	resist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	subcloned	subclon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HCD57-	HCD57-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	SREI	SREI	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2861
# text = Constitutive activations of PKB/Akt, STAT5a, and STAT5b were noted in these EPO-independent cells.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activations	activation	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	STAT5a	STAT5a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	b	b	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	EPO	Epo	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-independent	-independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2862
# text = PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity.
1	PI3	PI3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	_
13	because	because	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	PI3	PI3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-kinase	-kinase	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
18	LY294002	LY294002	NUM	CD	NumType=Card	_	_	_	_
19	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
22	PKB	Pkb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	factor-dependent	factor-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2863
# text = The LY294002 study showed that proliferation and viability of both HCD57-SREI and HCD57 cells correlated with the activity of PKB/Akt; however, PKB/Akt activity alone did not protect these cells from apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	LY294002	Ly294002	NUM	CD	NumType=Card	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	viability	viability	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	HCD57-SREI	HCD57-SREI	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	HCD57	HCD57	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	alone	alone	ADV	RB	_	_	_	_	_
31	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2864
# text = Treatment of HCD57 cells with SCF also activated PKB/Akt, but did not protect from apoptosis.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HCD57	HCD57	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	SCF	SCF	PROPN	NNP	Number=Sing	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2865
# text = This result suggested that PKB/PI3-kinase activity is necessary but not sufficient to promote viability and/or proliferation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	PI3	PI3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-kinase	-kinase	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
17	viability	viability	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	or	or	CCONJ	CC	_	_	_	_	_
21	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2866
# text = Constitutive STAT5 activity, activated through an unknown pathway not including JAK2 or EPOR, may act in concert with the constitutive PI3-kinase/PKB/Akt pathway to protect the EPO-independent HCD57-SREI cells from apoptosis and promote limited proliferation.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	STAT5	stat5	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	JAK2	JAK2	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	EPOR	Epor	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	PI3-kinase	PI3-kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	Akt	Akt	ADJ	JJS	Degree=Sup	_	_	_	_
28	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	EPO	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
35	HCD57-SREI	Hcd57-srei	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
41	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
42	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2867
# text = Document 003003337 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003337	003003337	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2868
# text = Clonality of isolated eosinophils in the hypereosinophilic syndrome.
1	Clonality	Clonality	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	hypereosinophilic	hypereosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
8	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2869
# text = The idiopathic hypereosinophilic syndrome (IHES) is a rare disorder characterized by unexplained, persistent eosinophilia associated with multiple organ dysfunction due to eosinophilic tissue infiltration.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	idiopathic	idiopathic	ADJ	JJ	Degree=Pos	_	_	_	_
3	hypereosinophilic	hypereosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
4	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IHES	IHES	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
11	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
12	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	unexplained	unexplain	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
17	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
21	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
22	dysfunction	dysfunction	NOUN	NN	Number=Sing	_	_	_	_
23	due	due	ADP	IN	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
26	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
27	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2870
# text = In the absence of karyotypic abnormalities, there is no specific test to detect clonal eosinophilia in IHES.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	karyotypic	karyotypic	ADJ	JJ	Degree=Pos	_	_	_	_
6	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	there	there	PRON	EX	_	_	_	_	_
9	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	no	no	DET	DT	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	test	test	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
15	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	eosinophilia	eosinophilion	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	IHES	IHES	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2871
# text = Analysis of X-chromosome inactivation patterns can be used to determine whether proliferative disorders are clonal in origin.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	chromosome	chromosome	ADJ	JJ	Degree=Pos	_	_	_	_
6	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
7	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
13	whether	whether	SCONJ	IN	_	_	_	_	_
14	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
15	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	origin	origin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2872
# text = Methylation of HpaII and Hha I sites near the polymorphic trinucleotide repeat of the human androgen receptor gene (HUMARA) has been shown to correlate with X-inactivation.
1	Methylation	Methylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HpaII	HpaII	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Hha	Hha	PROPN	NNP	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	near	near	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
11	trinucleotide	trinucleotide	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HUMARA	HUMARA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2873
# text = In this study, we have used the polymerase chain reaction (PCR) with nested primers to analyze X-inactivation patterns of the HUMARA loci in purified eosinophils from female patients with eosinophilia.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
10	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
11	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	nested	nest	ADJ	JJ	Degree=Pos	_	_	_	_
17	primers	primer	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
20	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
23	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	HUMARA	HUMARA	PROPN	NNP	Number=Sing	_	_	_	_
27	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
30	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2874
# text = Peripheral blood eosinophils were isolated by their autofluoresence using flow cytometric sorting.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	autofluoresence	autofluoresence	NOUN	NN	Number=Sing	_	_	_	_
9	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
10	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
11	cytometric	cytometric	NOUN	NN	Number=Sing	_	_	_	_
12	sorting	sorting	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2875
# text = Eosinophils purified from a female patient presenting with IHES were found to show a clonal pattern of X-inactivation.
1	Eosinophils	Eosinophils	NOUN	NNS	Number=Plur	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
6	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
7	presenting	present	VERB	VBG	VerbForm=Ger	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	IHES	IHES	PROPN	NNP	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	X	x	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-inactivation	-inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2876
# text = Eosinophil-depleted leukocytes from this patient were polyclonal by HUMARA analysis, thus excluding skewedness of random X-inactivation.
1	Eosinophil	Eosinophil	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	HUMARA	HUMARA	PROPN	NNP	Number=Sing	_	_	_	_
12	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	thus	thus	ADV	RB	_	_	_	_	_
15	excluding	exclude	VERB	VBG	VerbForm=Ger	_	_	_	_
16	skewedness	skewedness	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	random	random	NOUN	NN	Number=Sing	_	_	_	_
19	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2877
# text = After corticosteroid suppression of her blood eosinophilia, a clonal population of eosinophils could no longer be detected in purified eosinophils.
1	After	after	ADP	IN	_	_	_	_	_
2	corticosteroid	corticosteroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	her	she	PRON	PRP$	Gender=Fem|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	population	population	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	no	no	ADV	RB	_	_	_	_	_
16	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2878
# text = In contrast, eosinophils purified from a patient with Churg-Strauss syndrome and from six patients with reactive eosinophilias attributed to allergy, parasitic infection, or drug reaction showed a polyclonal pattern of X-inactivation by HUMARA analysis.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
5	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	Churg	Churg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Strauss	Strauss	PROPN	NNP	Number=Sing	_	_	_	_
13	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	six	six	NUM	CD	NumType=Card	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
20	eosinophilias	eosinophilia	NOUN	NNS	Number=Plur	_	_	_	_
21	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	allergy	allergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	parasitic	parasitic	ADJ	JJ	Degree=Pos	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
30	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
31	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
34	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	X	x	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-inactivation	-inactivation	NOUN	NN	Number=Sing	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	HUMARA	HUMARA	PROPN	NNP	Number=Sing	_	_	_	_
40	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2879
# text = The finding of clonal eosinophilia in a patient presenting with IHES indicates that such patients may have, in reality, a low-grade clonal disorder that can be distinguished from reactive eosinophilias by HUMARA analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
9	presenting	present	VERB	VBG	VerbForm=Ger	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	IHES	IHES	PROPN	NNP	Number=Sing	_	_	_	_
12	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	have	have	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	reality	reality	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	grade	grade	NOUN	NN	Number=Sing	_	_	_	_
26	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
27	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	distinguished	distinguish	ADJ	JJ	Degree=Pos	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
34	eosinophilias	eosinophilia	NOUN	NNS	Number=Plur	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	HUMARA	HUMARA	ADJ	JJ	Degree=Pos	_	_	_	_
37	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2880
# text = Further, the method described can be used to monitor disease progression.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	method	method	NOUN	NN	Number=Sing	_	_	_	_
5	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
11	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
12	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2881
# text = Document 003003338 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003338	003003338	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2882
# text = Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.
1	Mice	mice	NOUN	NN	Number=Sing	_	_	_	_
2	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	55	55	NUM	CD	NumType=Card	_	_	_	_
6	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	endotoxic	endotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	yet	yet	CCONJ	CC	_	_	_	_	_
18	succumb	succumb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
21	monocytogenes	monocytogene	NOUN	NNS	Number=Plur	_	_	_	_
22	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2883
# text = The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
3	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
4	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	55	55	NUM	CD	NumType=Card	_	_	_	_
22	kd	k	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	75	75	NUM	CD	NumType=Card	_	_	_	_
28	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TNFRp75	Tnfrp75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2884
# text = Using gene targeting, we generated a TNFRp55-deficient mouse strain.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	targeting	targeting	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	strain	strain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2885
# text = Cells from TNFRp55-/-mutant mice lack expression of TNFRp55 but display normal numbers of high affinity TNFRp75 molecules.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	TNFRp55	TNFRp55	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-/-	-/-	PUNCT	.	_	_	_	_	SpaceAfter=No
5	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
6	mice	mouse	NOUN	NN	Number=Sing	_	_	_	_
7	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
18	TNFRp75	TNFRp75	NUM	CD	NumType=Card	_	_	_	_
19	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2886
# text = Thymocyte development and lymphocyte populations are unaltered, and clonal deletion of potentially self-reactive T cells is not impaired.
1	Thymocyte	Thymocyte	NOUN	NN	Number=Sing	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	unaltered	unalter	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	potentially	potentially	ADV	RB	_	_	_	_	_
14	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2887
# text = However, TNF signaling is largely abolished, as judged by the failure of TNF to induce NF-kappa B in T lymphocytes from TNFRp55-deficient mice.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TNF	TNF	SCONJ	IN	_	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	largely	largely	ADV	RB	_	_	_	_	_
7	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	TNFRp55	TNFRp55	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
29	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2888
# text = The loss of TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	renders	render	NOUN	NNS	Number=Plur	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	resistant	resistant	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	lethal	lethal	ADJ	JJ	Degree=Pos	_	_	_	_
11	dosages	dosage	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	lipopolysaccharides	lipopolysaccharide	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
17	aureus	aureus	ADV	RB	_	_	_	_	_
18	enterotoxin	enterotoxin	ADP	IN	_	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2889
# text = In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	severely	severely	ADV	RB	_	_	_	_	_
10	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
13	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
14	monocytogenes	monocytogene	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	readily	readily	ADV	RB	_	_	_	_	_
17	succumb	succumb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2890
# text = Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	55	55	NUM	CD	NumType=Card	_	_	_	_
5	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
6	TNFR	Tnfr	PROPN	NNP	Number=Sing	_	_	_	_
7	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	decisive	decisive	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	's	's	PART	POS	_	_	_	_	_
15	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
16	against	against	ADP	IN	_	_	_	_	_
17	microorganisms	microorganism	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2891
# text = Document 003003339 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003339	003003339	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2892
# text = T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	proceeds	proceed	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	phases	phase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2893
# text = Much of our focus in understanding Th1/Th2 development has been on the signals delivered by IL-12 and IL-4 as final determinants of terminal T cell differentiation.
1	Much	much	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	focus	focus	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
7	Th1	th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	delivered	deliver	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	12	12	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	final	final	ADJ	JJ	Degree=Pos	_	_	_	_
27	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2894
# text = Because extinction of IL-12 signaling in early Th2 development could potentially be important in imprinting a more permanent Th2 phenotype on a population of T cells, we have also examined various parameters regulating the IL-12 signaling pathway.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
11	development	development	NOUN	NN	Number=Sing	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	potentially	potentially	ADV	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	imprinting	imprint	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	more	more	ADV	RBR	_	_	_	_	_
20	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
21	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
22	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	population	population	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
31	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
35	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
36	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	12	12	NUM	CD	NumType=Card	_	_	_	_
41	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
42	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2895
# text = Whereas IL-4 appears to repress functional IL-12 signaling through inhibition of IL-12R beta 2 expression, IFN-gamma in the mouse, and IFN-alpha in the human appear to induce IL-12R beta 2 expression and promote IL-12 responsiveness.
1	Whereas	whereas	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL-	IL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	12R	12R	NOUN	NN	Number=Sing	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	appear	appear	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-12R	-12R	PROPN	NNP	Number=Sing	_	_	_	_
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
46	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	12	12	NUM	CD	NumType=Card	_	_	_	_
49	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2896
# text = We propose that Th1 development can be considered in two stages, capacitance and development.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
5	development	development	NOUN	NN	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	capacitance	capacitance	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2897
# text = Capacitance would simply involve expression of IL-12R beta 1 and beta 2 subunits, regulated by TCR, IL-4 and IFNs.
1	Capacitance	Capacitance	NOUN	NN	Number=Sing	_	_	_	_
2	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
3	simply	simply	ADV	RB	_	_	_	_	_
4	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL-	IL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	12R	12R	NOUN	NN	Number=Sing	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IFNs	IFNs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2898
# text = The second stage, development, we propose is the true IL-12 induced developmental stage, involving expression of Stat4 inducible proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	12	12	NUM	CD	NumType=Card	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
17	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Stat4	Stat4	NUM	CD	NumType=Card	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2899
# text = In the human, this may also occur via IFN-alpha, which is able to activate Stat4.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	human	human	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
9	via	via	ADP	IN	_	_	_	_	_
10	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
19	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2900
# text = It is perhaps possible that all of Stat4 actions on Th1 development may be exert directly by Stat4 at the IFN-gamma gene, however we suggest that, more likely, Stat4 may act to induce Th1 development through the induction of other non-cytokine genes, whose stable expression maintains the transcriptional state of a Th1 cell.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	perhaps	perhaps	ADV	RB	_	_	_	_	_
4	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat4	Stat4	NUM	CD	NumType=Card	_	_	_	_
9	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
12	development	development	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
16	directly	directly	ADV	RB	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	however	however	ADV	RB	_	_	_	_	_
27	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	likely	likely	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
39	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
40	development	development	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
46	non-cytokine	non-cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
50	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
51	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
52	maintains	maintain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
55	state	state	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
58	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
59	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2901
# text = Document 003003343 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003343	003003343	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2902
# text = Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Smad6	Smad6	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Smad7	Smad7	NUM	CD	NumType=Card	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	bone	bone	PRON	NN	Number=Sing	_	_	_	_
9	morphogenetic	morphogenetic	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activin	activin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2903
# text = Smad6 and Smad7 prevent ligand-induced activation of signal-transducing Smad proteins in the transforming growth factor-beta family.
1	Smad6	Smad6	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	Smad7	Smad7	NUM	CD	NumType=Card	_	_	_	_
4	prevent	prevent	ADJ	JJ	Degree=Pos	_	_	_	_
5	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	transducing	transducing	VERB	VBG	VerbForm=Ger	_	_	_	_
13	Smad	Smad	ADJ	JJ	Degree=Pos	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
18	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2904
# text = Here we demonstrate that both Smad6 and Smad7 are human bone morphogenetic protein-2 (hBMP-2)-inducible antagonists of hBMP-2-induced growth arrest and apoptosis in mouse B cell hybridoma HS-72 cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	Smad6	smad6	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Smad7	Smad7	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
12	morphogenetic	morphogenetic	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	hBMP	hbmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
23	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	hBMP	hbmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
31	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	hybridoma	hybridoma	NOUN	NN	Number=Sing	_	_	_	_
39	HS	h	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	72	72	NUM	CD	NumType=Card	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2905
# text = Moreover, we confirmed that the ectopic expressions of Smad6 and Smad7 inhibited the hBMP-2-induced Smad1/Smad5 phosphorylation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	confirmed	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expressions	expression	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Smad6	Smad6	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Smad7	Smad7	NUM	CD	NumType=Card	_	_	_	_
13	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	hBMP	hbmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	Smad1	smad1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Smad5	smad5	NUM	CD	NumType=Card	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2906
# text = We previously reported that Smad7 is an activin A-inducible antagonist of activin A-induced growth arrest and apoptosis in HS-72 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	Smad7	Smad7	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	activin	activin	NOUN	NN	Number=Sing	_	_	_	_
9	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
12	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	activin	activin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
19	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	72	72	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2907
# text = Interestingly, although mRNA expression of Smad6 was induced by activin A in HS-72 cells, Smad6 showed no antagonistic effect on activin A-induced growth arrest and apoptosis.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Smad6	smad6	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	activin	activin	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	72	72	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Smad6	Smad6	PROPN	NNP	Number=Sing	_	_	_	_
20	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	activin	activin	ADP	IN	_	_	_	_	_
26	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
30	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2908
# text = Moreover, we found that the ectopic expression of Smad7, but not Smad6, inhibited the activin A-induced Smad2 phosphorylation in HS-72 cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Smad7	Smad7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	Smad6	Smad6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activin	activin	NOUN	NN	Number=Sing	_	_	_	_
19	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Smad2	smad2	NOUN	NN	Number=Sing	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	72	72	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2909
# text = Thus, Smad6 and Smad7 exhibit differential inhibitory effects in bone morphogenetic protein-2- and activin
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Smad6	Smad6	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Smad7	Smad7	NUM	CD	NumType=Card	_	_	_	_
6	exhibit	exhibit	NOUN	NN	Number=Sing	_	_	_	_
7	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
12	morphogenetic	morphogenetic	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	activin	activin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2910
# text = A-mediated signaling in B lineage cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2911
# text = Document 003003344 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003344	003003344	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2912
# text = The interleukin-5/receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak-STAT pathways in eosinophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	Lyn	Lyn	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	propagates	propagate	NOUN	NNS	Number=Plur	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
32	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2913
# text = We have shown that the interaction of interleukin (IL)-5 with the receptor activates Lyn tyrosine kinase within 1 min and Jak2 tyrosine kinase within 1-3 min.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	Lyn	Lyn	PROPN	NNP	Number=Sing	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	min	min	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	within	within	ADP	IN	_	_	_	_	_
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	3	3	NUM	CD	NumType=Card	_	_	_	_
32	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2914
# text = IL-5 also stimulates GTP binding to p21ras.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2915
# text = The signal is subsequently propagated through the activation of Raf-1, MEK, and MAP kinases as shown by their increased autophosphorylation in vitro and phosphorylation in situ.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	subsequently	subsequently	ADV	RB	_	_	_	_	_
5	propagated	propagate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	MAP	map	ADJ	JJ	Degree=Pos	_	_	_	_
18	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	autophosphorylation	autophosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	situ	situ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2916
# text = Jak2 kinase has been shown to phosphorylate
1	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 2917
# text = STAT nuclear proteins.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2918
# text = The activation of STAT nuclear factors was studied by electrophoretic mobility shift assay using a gamma activation site (GAS) probe.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
11	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
12	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
13	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2919
# text = We found that IL-5 induces two GAS-binding proteins in eosinophils, one of which is STAT1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	GAS	Ga	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Int	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2920
# text = We conclude that IL-5 induced signals are propagated through two distinct pathways: (1) Lyn-->Ras-->Raf-1-->MEK-->MAP kinase and (2) Jak2-->STAT1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	induced	induced	ADJ	JJ	Degree=Pos	_	_	_	_
8	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	propagated	propagate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	1	1	X	LS	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	Lyn	Lyn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-->	-->	PUNCT	,	_	_	_	_	SpaceAfter=No
21	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-->	-->	PUNCT	,	_	_	_	_	SpaceAfter=No
23	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1-->	1-->	SYM	NFP	_	_	_	_	SpaceAfter=No
26	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-->	-->	SYM	NFP	_	_	_	_	SpaceAfter=No
28	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	2	2	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-->	-->	SYM	NFP	_	_	_	_	SpaceAfter=No
36	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2921
# text = Document 003003345 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003345	003003345	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2922
# text = Analysis of the modulation of transcriptional activity in myelopoiesis and leukemogenesis.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	myelopoiesis	myelopoiesis	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	leukemogenesis	leukemogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2923
# text = Acute myeloid leukemia (AML) is still associated with a mortality of 60 to 80%.
1	Acute	Acute	ADJ	JJ	Degree=Pos	_	_	_	_
2	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	AML	AML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	still	still	ADV	RB	_	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mortality	mortality	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	60	60	NUM	CD	NumType=Card	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	80%	80%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2924
# text = AML is characterized by a block in myeloid differentiation.
1	AML	AML	ADV	RB	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	block	block	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2925
# text = The transcription factors PU.1 and C/EBPalpha are responsible for normal myeloid differentiation from stem cells to monocytes or granulocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	EBPalpha	EBPalpha	PROPN	NNP	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2926
# text = In particular, PU.1 induces expression of the macrophage colony-stimulating factor (M-CSF) receptor and the development of monocytes, whereas C/EBPalpha increases the expression of the granulocyte colony-stimulating factor (G-CSF) receptor and leads to mature granulocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
10	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	C/	C/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	EBPalpha	EBPalpha	PROPN	NNP	Number=Sing	_	_	_	_
29	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
35	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
48	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2927
# text = In AML, chromosomal aberrations result in oncoproteins such as AML1/ETO, PML/RARalpha, or activated Ras, which can deregulate genes important for normal myelopoiesis.
1	In	in	ADP	IN	_	_	_	_	_
2	AML	aml	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
5	aberrations	aberration	NOUN	NNS	Number=Plur	_	_	_	_
6	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
9	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	AML1/	Aml1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
12	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	deregulate	deregulate	VERB	VB	VerbForm=Inf	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	myelopoiesis	myelopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2928
# text = Thus, AML1/ETO can bind to the transcription factor C/EBPalpha, inhibit C/EBPalpha-dependent transcription, and block granulocytic differentiation.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	AML1/	AML1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
4	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	EBPalpha	EBPalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	C/EBPalpha	C/EBPalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	block	block	ADJ	JJ	Degree=Pos	_	_	_	_
23	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2929
# text = However, AML1/ETO can also synergize with the transcription factor AML1 to enhance the activity of the M-CSF receptor promoter.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	AML1/ETO	AML1/ETO	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	synergize	synergize	VERB	VB	VerbForm=Inf	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2930
# text = On the other hand, the PML/RARalpha fusion protein causes transcriptional repression by recruiting the nuclear corepressor (N-CoR) histone deacetylase complex to the DNA, which results in decreased histone acetylation and a repressive chromatin organization.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	recruiting	recruit	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	corepressor	corepressor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	N	and	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CoR	CoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
26	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	DET	WDT	PronType=Int	_	_	_	_
33	results	result	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
37	acetylation	acetylation	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
41	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
42	organization	organization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2931
# text = Here we describe methods to investigate whether and how signaling agonists induce myeloid differentiation and how oncoproteins might cause AML by modulating the activity of transcription factors that are pivotal for normal myeloid development.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	methods	method	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	how	how	ADV	WRB	PronType=Int	_	_	_	_
10	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
11	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
12	induce	induce	ADV	RB	_	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	how	how	ADV	WRB	PronType=Int	_	_	_	_
17	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
18	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
19	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
20	AML	AML	ADV	RB	_	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
33	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
34	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2932
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2933
# text = Document 003003348 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003348	003003348	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2934
# text = Interferon-beta mediates stromal cell rescue of T cells from apoptosis.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
4	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
5	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2935
# text = The resolution of immune responses is characterized by extensive apoptosis of activated T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
5	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2936
# text = However, to generate and maintain immunological memory, some antigen-specific T cells must survive and revert to a resting G0/G1 state.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
7	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
8	memory	memory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	some	some	DET	DT	_	_	_	_	_
11	antigen-specific	antigen-specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
15	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
21	G0/G1	G0/g1	NOUN	NN	Number=Sing	_	_	_	_
22	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2937
# text = Cytokines that bind to the common gamma chain of the IL-2 receptor promote the survival of T cell blasts, but also induce proliferation.
1	Cytokines	Cytokine	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2938
# text = In contrast, soluble factors secreted by stromal cells induce
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	induce	induce	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2939
# text = Tcell survival in a resting G0/G1 state.
1	Tcell	Tcell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	resting	resting	NOUN	NN	Number=Sing	_	_	_	_
6	G0/G1	G0/G1	NUM	CD	NumType=Card	_	_	_	_
7	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2940
# text = We now report that interferon-beta is the principal mediator of stromal cell-mediated
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	principal	principal	NOUN	NN	Number=Sing	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 2941
# text = Tcell rescue from apoptosis.
1	Tcell	Tcell	ADJ	JJ	Degree=Pos	_	_	_	_
2	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2942
# text = Interferon-alpha and -beta promote the reversion of blast Tcells to a resting G0/G1 configuration with all the characteristic features of stromal cell rescue; such as high Bcl-XL expression and low Bcl-2.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	beta	beta	PART	TO	Abbr=Yes	_	_	_	_
7	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	reversion	reversion	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
12	Tcells	Tcell	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
16	G0/G1	G0/g1	NOUN	NN	Number=Sing	_	_	_	_
17	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	all	all	DET	PDT	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
22	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	XL	XL	PROPN	NNP	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
37	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2943
# text = Type I interferons and stromal cells stimulate apparently identical signaling pathways, leading to STAT-1 activation.
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	apparently	apparently	ADV	RB	_	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2944
# text = We also show that this mechanism may play a fundamental role in the persistence of T cells at sites of chronic inflammation; suggesting that chronic inflammation is an aberrant consequence of immunological memory.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
22	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
27	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
31	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
34	memory	memory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2945
# text = Document 003003351 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003351	003003351	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2946
# text = Effects of intranasal glucocorticoids on endogenous glucocorticoid peripheral and central function.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intranasal	intranasal	ADJ	JJ	Degree=Pos	_	_	_	_
4	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2947
# text = Glucocorticoids are among the most potent antiinflammatory agents that can be used in the treatment of rhinitis.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	among	among	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	most	most	ADV	RBS	_	_	_	_	_
6	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
7	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	rhinitis	rhinitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2948
# text = Their mechanisms of action are multiple and complex and a number of reports describe significant systemic effects of locally administered glucocorticoids.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	number	number	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
14	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
16	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	locally	locally	ADV	RB	_	_	_	_	_
20	administered	administer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2949
# text = In order to evaluate the short-term systemic effects of intranasally administered glucocorticoids, 14 normal healthy subjects were treated with two doses of either budesonide (BUD) or fluticasone propionate (FP) for 2 weeks.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	term	term	NOUN	NN	Number=Sing	_	_	_	_
9	systemic	systemic	NOUN	NN	Number=Sing	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	intranasally	intranasally	ADV	RB	_	_	_	_	_
13	administered	administer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	14	14	NUM	CD	NumType=Card	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
19	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	two	two	NUM	CD	NumType=Card	_	_	_	_
24	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	either	either	DET	DT	_	_	_	_	_
27	budesonide	budesonide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	BUD	Bud	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	fluticasone	fluticasone	PRON	NN	Number=Sing	_	_	_	_
33	propionate	propionate	ADJ	JJ	Degree=Pos	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	FP	FP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2950
# text = Before treatment, at regular intervals during the treatment, 1 week and finally 6 weeks after termination of treatment, the effects on glucocorticoid receptor (GR) and methallothionein (MTIIa) mRNA expression levels were examined in peripheral lymphocytes using a solution hybridization assay.
1	Before	before	ADP	IN	_	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	regular	regular	ADJ	JJ	Degree=Pos	_	_	_	_
6	intervals	interval	NOUN	NNS	Number=Plur	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	week	week	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	finally	finally	ADV	RB	_	_	_	_	_
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	weeks	week	NOUN	NNS	Number=Plur	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	termination	termination	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	methallothionein	methallothionein	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	MTIIa	MTIIa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
42	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
43	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	solution	solution	NOUN	NN	Number=Sing	_	_	_	_
46	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
47	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2951
# text = Serum cortisol, osteocalcin and urinary cortisol levels were also determined.
1	Serum	Serum	NOUN	NN	Number=Sing	_	_	_	_
2	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	osteocalcin	osteocalcin	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
7	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2952
# text = An insulin tolerance test (ITT) was performed at the end of the second week of treatment and at the end of the 6-week washout period with no statistically significant change in cortisol response.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
3	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
4	test	test	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	ITT	ITT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	end	end	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	week	week	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	end	end	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	week	week	NOUN	NN	Number=Sing	_	_	_	_
28	washout	washout	ADP	IN	_	_	_	_	_
29	period	period	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	no	no	DET	DT	_	_	_	_	_
32	statistically	statistically	ADV	RB	_	_	_	_	_
33	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
34	change	change	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	cortisol	cortisol	ADJ	JJ	Degree=Pos	_	_	_	_
37	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2953
# text = In peripheral lymphocytes, GR mRNA levels were significantly down-regulated.
1	In	in	ADP	IN	_	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	significantly	significantly	ADV	RB	_	_	_	_	_
10	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2954
# text = MTIIa mRNA levels increased significantly.
1	MTIIa	MTIIa	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	significantly	significantly	ADV	RB	_	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2955
# text = Serum osteocalcin decreased significantly during treatment with both BUD and FP.
1	Serum	Serum	PROPN	NNP	Number=Sing	_	_	_	_
2	osteocalcin	osteocalcin	ADV	RB	_	_	_	_	_
3	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	BUD	Bud	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	FP	FP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2956
# text = Serum cortisol decreased after 1 week of treatment whereas urinary cortisol was not affected until the second week of treatment.
1	Serum	Serum	PROPN	NNP	Number=Sing	_	_	_	_
2	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
3	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	week	week	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	whereas	wherea	SCONJ	IN	_	_	_	_	_
10	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
11	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	until	until	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	week	week	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2957
# text = In conclusion, intranasal glucocorticoids at clinically recommended doses have not only significant systemic effects on adrenal function, but also have an effect on specific gene expression in peripheral lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	intranasal	intranasal	ADJ	JJ	Degree=Pos	_	_	_	_
5	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	clinically	clinically	ADV	RB	_	_	_	_	_
8	recommended	recommend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2958
# text = These effects are receptor-dependent, reversible, and according to serum and urinary cortisol levels and ITT, leave the hypothalamic-pituitary-adrenal function intact.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	according	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
16	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	ITT	Itt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	leave	leave	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	intact	intact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2959
# text = Finally, these short-term systemic effects were not associated with any of the noticeable side-effects usually observed during long-term treatment with glucocorticoids.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	term	term	NOUN	NN	Number=Sing	_	_	_	_
7	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	any	any	DET	DT	_	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	noticeable	noticeable	ADJ	JJ	Degree=Pos	_	_	_	_
17	side	side	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
20	usually	usually	ADV	RB	_	_	_	_	_
21	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	term	term	NOUN	NN	Number=Sing	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2960
# text = Document 003003354 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003354	003003354	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2961
# text = Association of the interleukin-4 receptor alpha chain with p47phox, an activator of the phagocyte NADPH oxidase in B cells.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	phagocyte	phagocyte	ADJ	JJ	Degree=Pos	_	_	_	_
18	NADPH	NADPh	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
19	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2962
# text = Interleukin (IL)-4 plays an important role in IgE synthesis in B cells and in Th2 differentiation in T cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	_
13	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2963
# text = IL-4 conducts its biological activities through binding to the IL-4 receptor (IL-4R) on the surface of target cells.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	conducts	conduct	NOUN	NNS	Number=Plur	_	_	_	_
5	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
7	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
8	through	through	SCONJ	IN	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4R	4r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	target	target	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2964
# text = IL-4R are thought to be composed of the IL-4R alpha chain (IL-4R alpha) and either the IL-2R gamma chain or the IL-13R alpha chain.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4R	4r	PROPN	NNP	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	either	either	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	13R	13r	PROPN	NNP	Number=Sing	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2965
# text = We have previously shown that the membrane-proximal portion in the cytoplasmic domain of the human IL-4R alpha (hIL-4R alpha) is critical for proliferation, generation of germline epsilon transcript, and activation of STAT6, based on analyses of truncated hIL-4R alphas.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
10	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4R	4r	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
36	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
37	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	hIL	hIL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	4R	4R	NOUN	NN	Number=Sing	_	_	_	_
52	alphas	alpha	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2966
# text = In this study, we found that p47phox, an activator of the phagocyte NADPH oxidase, binds to this portion by the two-hybrid system.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	phagocyte	phagocyte	ADJ	JJ	Degree=Pos	_	_	_	_
15	NADPH	NADPH	PROPN	NNP	Number=Sing	_	_	_	_
16	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2967
# text = Furthermore, we observed the association of p47phox with the hIL-4R alpha in B cells derived from a normal donor.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	association	association	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	donor	donor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2968
# text = These results suggest that p47phox is involved in the signal transduction of IL-4 in B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2969
# text = However, activation of STAT6, CD23 expression, and IgE synthesis induced by IL-4 were not affected in p47phox-deficient patients, which raises the possibility that p47phox may be important in other signaling activities as well in B cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
12	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	raises	raise	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
38	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
39	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
40	as	as	ADV	RB	_	_	_	_	_
41	well	well	ADV	RB	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2970
# text = Document 003003355 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003355	003003355	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2971
# text = PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.
1	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
12	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	ADP	IN	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2972
# text = Growth factor receptors play an important role in hematopoiesis.
1	Growth	growth	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	hematopoiesis	hematopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2973
# text = In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis, we initiated a study investigating the transcription factors activating the expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha gene.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	initiated	initiate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	study	study	NOUN	NN	Number=Sing	_	_	_	_
22	investigating	investigate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
34	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
44	alpha	alpha	ADP	IN	_	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2974
# text = Here, we demonstrate that the human GM-CSF receptor alpha promoter directs reporter gene activity in a tissue-specific fashion in myelomonocytic cells, which correlates with its expression pattern as analyzed by reverse transcription PCR.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	directs	direct	NOUN	NNS	Number=Plur	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	pattern	pattern	ADJ	JJ	Degree=Pos	_	_	_	_
34	as	as	SCONJ	IN	_	_	_	_	_
35	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2975
# text = The GM-CSF receptor alpha promoter contains an important functional site between positions -53 and -41 as identified by deletion analysis of reporter constructs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
15	-53	-53	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	41	41	NUM	CD	NumType=Card	_	_	_	_
19	as	as	ADV	RB	_	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
23	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2976
# text = We show that the myeloid and B cell transcription factor PU.1 binds specifically to this site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
12	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2977
# text = Furthermore, we demonstrate that a CCAAT site located upstream of the PU.1 site between positions -70 and -54 is involved in positive-negative regulation of the GM-CSF receptor alpha promoter activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	CCAAT	Ccaat	ADJ	JJ	Degree=Pos	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	70	70	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	54	54	NUM	CD	NumType=Card	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	alpha	alpha	ADP	IN	_	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2978
# text = C/EBP alpha is the major CCAAT/enhancer-binding protein (C/EBP) form binding to this site in nuclear extracts of U937 cells.
1	C/	C/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
3	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	C/	Cith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	U937	U937	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2979
# text = Point mutations of either the PU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of GM-CSF receptor alpha promoter activity in myelomonocytic cells only.
1	Point	point	ADJ	JJ	Degree=Pos	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	abolish	abolish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
25	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	alpha	alpha	ADP	IN	_	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	only	only	ADV	RB	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2980
# text = Furthermore, we demonstrate that in myeloid and B cell extracts, PU.1 forms a novel, specific, more slowly migrating complex (PU-SF) when binding the GM-CSF receptor alpha promoter PU.1 site.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
14	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	slowly	slowly	ADV	RB	_	_	_	_	_
22	migrating	migrating	VERB	VBG	VerbForm=Ger	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	SF	SF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	when	when	ADV	WRB	PronType=Int	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
35	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2981
# text = This is the first demonstration of a specific interaction with PU.1 on a myeloid PU.1 binding site.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2982
# text = The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of PU.1 to extracts from certain nonmyeloid cell types which do not express PU.1, including T cells and epithelial cells, but not from erythroid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	described	describe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	previously	previously	ADV	RB	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
29	nonmyeloid	nonmyeloid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	types	type	NOUN	NNS	Number=Plur	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
36	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
39	T	t	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	but	but	CCONJ	CC	_	_	_	_	_
46	not	not	ADV	RB	_	_	_	_	_
47	from	from	ADP	IN	_	_	_	_	_
48	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2983
# text = Furthermore, we demonstrate that the PU-SF complex binds to PU.1 sites found on a number of myeloid promoters, and its formation requires an intact PU.1 site adjacent to a single-stranded region.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	SF	SF	PROPN	NNP	Number=Sing	_	_	_	_
10	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
11	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	number	number	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
26	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
29	PU.1	PU.1	NOUN	NN	Number=Sing	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	adjacent	adjacent	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2984
# text = Expression of PU.1 in nonmyeloid cells can activate the GM-CSF receptor alpha promoter.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	nonmyeloid	nonmyeloid	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	promoter.	promoter.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2985
# text = Deletion of the amino-terminal region of PU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	SF	SF	PROPN	NNP	Number=Sing	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
25	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
30	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	SF	SF	PROPN	NNP	Number=Sing	_	_	_	_
37	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
41	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
50	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
51	alpha	alpha	ADP	IN	_	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2986
# text = Finally, we demonstrate that C/EBP alpha can also active the GM-CSF receptor alpha promoter in nonmyeloid cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	active	active	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	nonmyeloid	nonmyeloid	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2987
# text = (ABSTRACT TRUNCATED AT 400 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	400	400	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2988
# text = Document 003003358 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003358	003003358	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2989
# text = The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
18	CD62E	CD62E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	CD11b/CD18	CD11b/CD18	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	106	106	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2990
# text = Tepoxalin, a dual enzyme inhibitor of cyclooxygenase and 5-lipoxygenase has been shown to inhibit T-cell activation.
1	Tepoxalin	Tepoxalin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
5	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cyclooxygenase	cyclooxygenase	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2991
# text = Its immunosuppressive property is distinct from cyclosporin because only tepoxalin, but not cyclosporin, suppresses NF-kappa B activation.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	property	property	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
8	because	because	SCONJ	IN	_	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	tepoxalin	tepoxalin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2992
# text = Here we report that tepoxalin selectively inhibits intercellular adhesion molecule-1 (ICAM-1, CD54)/MAC-1 (CD11b/CD18) dependent adhesion of polymorphonuclear cells to IL-1 activated human umbilical vein endothelial cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
6	selectively	selectively	ADV	RB	_	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	CD54)	CD54)	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/MAC	/mac	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CD11b/CD18	CD11b/CD18	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
37	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
38	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2993
# text = The mechanism of inhibition is related to the surface expression of several cell adhesion molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2994
# text = Flow cytometry analyses on cultured cells that were treated with tepoxalin or antisense oligonucleotides to the P65/p50 subunit of NF-kappa B, and then stimulated with PMA, revealed a reduced expression of CD11b/CD18 on monocytic HL60 cells, and endothelial adhesion molecule-1 (CD62E) and vascular adhesion molecule-1 (CD106) on human umbilical vein endothelial cells.
1	Flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
14	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	P65	P65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	p50	p50	NUM	CD	NumType=Card	_	_	_	_
20	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	then	then	ADV	RB	PronType=Dem	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	CD11b/CD18	CD11b/CD18	NOUN	NN	Number=Sing	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
41	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
46	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
47	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	CD62E	Cd62e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
55	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
56	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	1	1	NUM	CD	NumType=Card	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	CD106	CD106	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	_
62	on	on	ADP	IN	_	_	_	_	_
63	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
64	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
65	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
66	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
67	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2995
# text = Expression of other adhesion molecules such as lymphocyte function associated-antigen-1 (CD11a/CD18) and CD54 were unaffected.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
6	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CD11a/CD18	CD11a/CD18	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CD54	CD54	PROPN	NNP	Number=Sing	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2996
# text = Tepoxalin also inhibited the secretion of a NF-kappa B regulated chemokine, IL-8, a known inducer of CD11b/CD18 expression.
1	Tepoxalin	Tepoxalin	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	CD11b/	Cd11b/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	18	18	NUM	CD	NumType=Card	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2997
# text = Thus the suppression of CD11b/CD18 expression by tepoxalin may involve IL-8.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CD11b/	CD11b/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	18	18	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2998
# text = Our results suggest that by inhibiting NF-kappa B activation, surface expression of several adhesion molecules can be modulated and that tepoxalin may be useful in treating selected adhesion mediated events such as leukocyte migration or atherosclerotic plaque formation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	by	by	SCONJ	IN	_	_	_	_	_
6	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	SCONJ	IN	_	_	_	_	_
29	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
30	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	events	event	NOUN	NNS	Number=Plur	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
37	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
40	plaque	plaque	NOUN	NN	Number=Sing	_	_	_	_
41	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2999
# text = Document 003003360 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003360	003003360	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3000
# text = Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation.
1	Chronic	Chronic	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	disrupts	disrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	control	control	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	via	via	ADP	IN	_	_	_	_	_
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3001
# text = Productive human immunodeficiency virus type 1 (HIV-1) infection causes sustained NF-kappaB DNA-binding activity in chronically infected monocytic cells.
1	Productive	Productive	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
14	sustained	sustain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	chronically	chronically	ADV	RB	_	_	_	_	_
24	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3002
# text = A direct temporal correlation exists between HIV infection and the appearance of NF-kappaB DNA-binding activity in myelomonoblastic PLB-985 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
4	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
5	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	myelomonoblastic	myelomonoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
22	PLB	PLB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	985	985	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3003
# text = To examine the molecular basis of constitutive NF-kappaB DNA-binding activity in HIV1 -infected cells, we analyzed the phosphorylation and turnover of IkappaBalpha protein, the activity of the double-stranded RNA-dependent protein kinase (PKR) and the intracellular levels of NF-kappaB subunits in the PLB-985 and U937 myeloid cell models.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HIV1	HIV1	PROPN	NNP	Number=Sing	_	_	_	_
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
42	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	PKR	PKR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
49	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
54	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	PLB	PLB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-985	-985	NUM	CD	NumType=Card	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	U937	U937	NUM	CD	NumType=Card	_	_	_	_
61	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
62	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
63	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3004
# text = HIV-1 infection resulted in constitutive, low-level expression of type 1 interferon (IFN) at the mRNA level.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3005
# text = Constitutive PKR activity was also detected in HIV-1-infected cells as a result of low-level IFN production, since the addition of anti-IFN-alpha/beta antibody to the cells decreased PKR expression.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	PKR	Pkr	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	result	result	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
22	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	since	since	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	anti-IFN-	anti-IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	alpha/	alpha/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	beta	beof	NOUN	NN	Number=Sing	_	_	_	_
31	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	PKR	Pkr	ADP	IN	_	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3006
# text = Furthermore, the analysis of IkappaBalpha turnover demonstrated an increased degradation of IkappaBalpha in HIV-1-infected cells that may account for the constitutive DNA binding activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	turnover	turnover	ADV	RB	_	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-infected	-infected	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3007
# text = A dramatic increase in the intracellular levels of NF-kappaB subunits c-Rel and NF-kappaB2 p100 and a moderate increase in NF-kappaB2 p52 and RelA(p65) were detected in HIV-1-infected cells, whereas NF-kappaB1 p105/p50 levels were not altered relative to the levels in uninfected cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB2	kappab2	NOUN	NN	Number=Sing	_	_	_	_
20	p100	p100	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
24	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	kappaB2	kappab2	NUM	CD	NumType=Card	_	_	_	_
29	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-infected	-infect	ADJ	JJ	Degree=Pos	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	whereas	whereas	SCONJ	IN	_	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
48	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
50	p50	p50	NUM	CD	NumType=Card	_	_	_	_
51	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	not	not	PART	RB	_	_	_	_	_
54	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
55	relative	relative	ADV	RB	_	_	_	_	_
56	to	to	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
61	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3008
# text = We suggest that HIV-1 infection of myeloid cells induces IFN production and PKR activity, which in turn contribute to enhanced IkappaBalpha phosphorylation and subsequent degradation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
12	IFN	Ifn	ADP	IN	_	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	PKR	Pkr	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
21	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
24	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
28	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3009
# text = Nuclear translocation of NF-kappaB subunits may ultimately increase the intracellular pool of NF-kappaB/IkappaBalpha by an autoregulatory mechanism.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	ultimately	ultimately	ADV	RB	_	_	_	_	_
10	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	pool	pool	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3010
# text = Enhanced turnover of IkappaBalpha and the accumulation of NF-kappaB/Rel proteins may contribute to the chronically activated state of HIV-1-infected cells.
1	Enhanced	enhance	ADJ	JJ	Degree=Pos	_	_	_	_
2	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	chronically	chronically	ADV	RB	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	state	state	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3011
# text = Document 003003364 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003364	003003364	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3012
# text = The role of gamma/delta T cell receptor positive cells in pregnancy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3013
# text = PROBLEM: Due to the lack of classical HLA antigens on the trophoblast, fetal antigens are possibly presented in a non major histocompatibility complex (MHC) restricted way.
1	PROBLEM	problem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
9	HLA	HLA	NOUN	NN	Number=Sing	_	_	_	_
10	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	trophoblast	trophoblast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
16	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	possibly	possibly	ADV	RB	_	_	_	_	_
19	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	non	non	X	AFX	_	_	_	_	_
23	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
24	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	restricted	restrict	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	way	way	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3014
# text = Decidual gammadelta
1	Decidual	Decidual	ADJ	JJ	Degree=Pos	_	_	_	_
2	gammadelta	gammadelta	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3015
# text = T cells, which significantly increase in number during pregnancy, might play a role in recognition of fetal antigens and also in determining the quality of the response to these antigens.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	significantly	significantly	ADV	RB	_	_	_	_	_
6	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
7	in	in	ADP	RP	_	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
20	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	in	in	SCONJ	IN	_	_	_	_	_
24	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	quality	quality	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3016
# text = Our study was aimed at investigating the role of this cell population in progesterone-dependent immunomodulation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	SCONJ	IN	_	_	_	_	_
6	investigating	investigate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	population	population	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunomodulation	immunomodulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3017
# text = METHOD OF STUDY:
1	METHOD	method	NOUN	NN	Number=Sing	_	_	_	_
2	OF	of	ADP	IN	_	_	_	_	_
3	STUDY	study	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3018
# text = Peripheral lymphocytes from healthy pregnant women and from habitual aborters were tested by immunocytochemistry for the presence of gamma/delta T cell receptor (TCR) and progesterone receptor.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
5	pregnant	pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
6	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	habitual	habitual	ADJ	JJ	Degree=Pos	_	_	_	_
10	aborters	aborter	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	immunocytochemistry	immunocytochemistry	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gamma/	gamma/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
20	delta	delof	PROPN	NNP	Number=Sing	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3019
# text = To investigate the effect of treatment with a pan anti gamma/delta antibody, lymphocytes were incubated for 3 hr with the antibody, and then interleukin (IL)-10, IL-12 and progesterone-induced blocking factor (PIBF) expression (by immuno-cytochemistry) as well as natural killer (NK) cell activity were determined.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	pan	pan	NOUN	NN	Number=Sing	_	_	_	_
10	anti	anti	X	AFX	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
14	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	then	then	ADV	RB	PronType=Dem	_	_	_	_
28	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	IL	IL	ADV	RB	_	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	12	12	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	blocking	blocking	NOUN	NN	Number=Sing	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	PIBF	PIBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	by	by	ADP	IN	_	_	_	_	_
50	immuno	immuno	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
51	-cytochemistry	-cytochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	_
53	as	as	ADV	RB	_	_	_	_	_
54	well	well	ADV	RB	Degree=Pos	_	_	_	_
55	as	as	ADP	IN	_	_	_	_	_
56	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
57	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
62	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
63	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
64	determined	determine	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3020
# text = RESULTS: In peripheral blood of healthy pregnant women the percentage of gamma/delta TCR+ cells was significantly higher (P < 0.001) than in that of recurrent aborters or of non-pregnant individuals.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
8	pregnant	pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
9	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gamma/	gammaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
15	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	P	NOUN	NN	Number=Sing	_	_	_	_
23	<	<	PUNCT	-LRB-	_	_	_	_	_
24	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	recurrent	recurrent	ADJ	JJ	Degree=Pos	_	_	_	_
31	aborters	aborter	NOUN	NNS	Number=Plur	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	non-pregnant	non-pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
35	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3021
# text = Ninety-seven percent of gamma/delta TCR+ pregnancy lymphocytes expressed progesterone receptor.
1	Ninety	Ninety	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	seven	seven	NUM	CD	NumType=Card	_	_	_	_
4	percent	percent	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	gamma/	gammaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
8	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	pregnancy	pregnancy	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3022
# text = Binding of a specific antibody to the gamma/delta TCR inhibited PIBF- as well as IL-10 production, whereas it increased NK activity and IL-12 expression.
1	Binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	gamma/	gammaith	SYM	NFP	_	_	_	_	SpaceAfter=No
9	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
10	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
11	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	PIBF	PIBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	10	10	NUM	CD	NumType=Card	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	whereas	SCONJ	IN	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	12	12	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3023
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3024
# text = These data suggest the role of gamma/delta TCR-bearing lymphocytes in progesterone-dependent immunomodulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	gamma/	gammaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
8	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
9	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bearing	bearing	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunomodulation	immunomodulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3025
# text = Document 003003368 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003368	003003368	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3026
# text = The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	12	12	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
13	p38	p38	NUM	CD	NumType=Card	_	_	_	_
14	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-activated	-activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	augmentation	augmentation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
26	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3027
# text = IL-12 and IL-2 can stimulate mitogen- or CD3-activated T cells to proliferate, produce IFN-gamma, and kill tumor cells.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
22	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	kill	kill	VERB	VB	VerbForm=Inf	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3028
# text = The magnitude of these functional responses is greatly augmented when T cells are activated by the combination of IL-12 and IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	greatly	greatly	ADV	RB	_	_	_	_	_
9	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	12	12	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3029
# text = Although peripheral blood T cells are largely unresponsive to these cytokines without prior activation, a small subset of CD8+ T cells (CD8+CD18bright) is strongly activated by the combination of IL-12 and IL-2.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	T	t	NOUN	NN	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	largely	largely	ADV	RB	_	_	_	_	_
8	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	without	without	ADP	IN	_	_	_	_	_
13	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
18	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	T	t	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CD8+CD18bright	CD8+CD18bright	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	strongly	strongly	ADV	RB	_	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	12	12	NUM	CD	NumType=Card	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3030
# text = In this report we show that the functional synergy between IL-12 and IL-2 in CD8+CD18bright T cells correlates with the activation of the stress kinases, p38 mitogen-activated protein (MAP) kinase and stress-activated protein kinase (SAPK)/Jun N-terminal kinase, but not with the activation of the extracellular signal-regulated kinases.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	12	12	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	CD8+CD	Cd8+cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	18bright	18bright	AUX	MD	VerbForm=Fin	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
30	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	p38	p38	NUM	CD	NumType=Card	_	_	_	_
33	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	SAPK	SAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
51	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
52	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
53	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
54	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	but	but	CCONJ	CC	_	_	_	_	_
57	not	not	ADV	RB	_	_	_	_	_
58	with	with	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
64	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
67	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3031
# text = The functional synergy between IL-2 and IL-12 is also associated with a prominent increase in STAT1 and STAT3 serine phosphorylation over that observed with IL-12 or IL-2 alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
18	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
23	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	over	over	ADP	IN	_	_	_	_	_
26	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	12	12	NUM	CD	NumType=Card	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3032
# text = By contrast, STAT tyrosine phosphorylation is not augmented over that seen with either cytokine alone.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	over	over	ADP	IN	_	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	seen	see	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	either	either	DET	DT	_	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3033
# text = A specific inhibitor of p38 MAP kinase completely inhibits the serine phosphorylation of STAT1 and STAT3 induced by IL-12 and IL-2 and abrogates the functional synergy between IL-12 and IL-2 without affecting
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p38	p38	NUM	CD	NumType=Card	_	_	_	_
6	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STAT1	STAT1	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	12	12	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
30	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	12	12	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	without	without	SCONJ	IN	_	_	_	_	_
40	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 3034
# text = STAT tyrosine phosphorylation.
1	STAT	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3035
# text = This suggests that p38 MAP kinase may play an important role in regulating
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	p38	p38	NUM	CD	NumType=Card	_	_	_	_
5	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	regulating	regulat	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 3036
# text = STAT serine phosphorylation in response to the combination of IL-12 and IL-2. Furthermore, these findings indicate that the optimal activation of T cells by IL-12 and IL-2 may depend on an interaction between the p38 MAP kinase and Janus kinase/STAT signaling pathways.
1	STAT	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	serine	serine	PRON	PRP	_	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	12	12	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_
18	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
22	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	12	12	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
43	between	between	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	p38	p38	NUM	CD	NumType=Card	_	_	_	_
46	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
47	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
50	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	/STAT	/stat	SCONJ	IN	_	_	_	_	_
52	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
53	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3037
# text = Document 003003369 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003369	003003369	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3038
# text = Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	hemorrhagic	hemorrhagic	ADJ	JJ	Degree=Pos	_	_	_	_
7	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
12	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
15	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3039
# text = Hemorrhagic shock (HS) initiates an inflammatory cascade that includes the production of cytokines and recruitment of neutrophils (PMN) and may progress to organ failure, inducing acute respiratory distress syndrome (ARDS).
1	Hemorrhagic	Hemorrhagic	ADJ	JJ	Degree=Pos	_	_	_	_
2	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	PMN	PMN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	progress	progress	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	organ	organ	VERB	VB	VerbForm=Inf	_	_	_	_
28	failure	failure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
31	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
32	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
33	distress	distress	NOUN	NN	Number=Sing	_	_	_	_
34	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	ARDS	ARDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3040
# text = To examine the hypothesis that interleukin-6 (IL-6) contributes to PMN infiltration and lung damage in HS, we examined the lungs of rats subjected to unresuscitated and resuscitated HS for the production of IL-6 and activation of Stat3.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	interleukin	interleukin	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	PMN	Pmn	VERB	VB	VerbForm=Inf	_	_	_	_
17	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
20	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
30	subjected	subject	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	unresuscitated	unresuscitated	VERB	VB	VerbForm=Inf	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	resuscitated	resuscitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	HS	H	NOUN	NNS	Number=Plur	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	production	production	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	6	6	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3041
# text = Using semiquantitative RT-PCR, we found a striking increase in IL-6 mRNA levels only in resuscitated HS, with peak levels observed 1 h after initiation of resuscitation.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
3	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	only	only	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	resuscitated	resuscitated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	HS	HS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	resuscitation	resuscitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3042
# text = Increased IL-6 protein expression was localized to bronchial and alveolar cells.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	6	6	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3043
# text = Electrophoretic mobility shift assay of protein extracts from shock lungs exhibited an increase in Stat3 activation with kinetics similar to IL-6 mRNA.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
10	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	_
11	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
19	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3044
# text = In situ DNA binding assay determined Stat3 activation predominantly within alveoli.
1	In	in	ADP	IN	_	_	_	_	_
2	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	assay	assay	ADV	RB	_	_	_	_	_
6	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	_
7	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	predominantly	predominantly	ADV	RB	_	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	alveoli	alveoli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3045
# text = Intratracheal instillation of IL-6 alone into normal rats resulted in PMN infiltration into lung interstitium and alveoli, marked elevation of bronchoalveolar lavage cellularity, and increased wet-to-dry ratio.
1	Intratracheal	Intratracheal	ADJ	JJ	Degree=Pos	_	_	_	_
2	instillation	instillation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	alone	alone	ADV	RB	_	_	_	_	_
8	into	into	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
11	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	PMN	Pmn	PROPN	NNP	Number=Sing	_	_	_	_
14	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
17	interstitium	interstitium	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	alveoli	alveoli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	bronchoalveolar	bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
25	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
26	cellularity	cellularity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	wet	wet	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dry	dry	ADJ	JJ	Degree=Pos	_	_	_	_
35	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3046
# text = These findings indicate that IL-6 production and Stat3 activation occur early in HS and may contribute to PMN-mediated lung injury, including ARDS after HS.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	occur	occur	NOUN	NN	Number=Sing	_	_	_	_
13	early	early	ADV	RB	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	PMN	Pmn	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
24	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
27	ARDS	ARDS	PROPN	NNP	Number=Sing	_	_	_	_
28	after	after	ADP	IN	_	_	_	_	_
29	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3047
# text = Document 003003371 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003371	003003371	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3048
# text = A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
8	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
13	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3049
# text = A novel B cell-restricted activity, required for high levels of octamer/Oct-dependent transcription from an immunoglobulin heavy chain (IgH) promoter, was detected in an in vitro system consisting of HeLa cell-derived extracts complemented with fractionated B cell nuclear proteins.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
23	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
36	system	system	NOUN	NN	Number=Sing	_	_	_	_
37	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
40	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
44	complemented	complement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	fractionated	fractionate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	B	b	NOUN	NN	Number=Sing	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
50	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3050
# text = The factor responsible for this activity was designated Oct coactivator from B cells (OCA-B).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
10	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	OCA	Oca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3051
# text = OCA-B stimulates the transcription from an IgH promoter in conjunction with either Oct-1 or Oct-2 but shows no significant effect on the octamer/Oct-dependent transcription of the ubiquitously expressed histone H2B promoter and the transcription of USF- and Sp1-regulated promoters.
1	OCA	Oca	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	B	B	PROPN	NNP	Number=Sing	_	_	_	_
4	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	no	no	DET	DT	_	_	_	_	_
25	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
40	H2B	H2b	NOUN	NN	Number=Sing	_	_	_	_
41	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	USF	USF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-regulated	-regulate	ADJ	JJ	Degree=Pos	_	_	_	_
51	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3052
# text = Taken together, our results suggest that OCA-B is a tissue-, promoter-, and factor-specific coactivator and that OCA-B may be a major determinant for B cell-specific activation of immunoglobulin promoters.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	OCA	OCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	factor	factor	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	OCA	OCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
32	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
40	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3053
# text = In light of the evidence showing physical and functional interactions between Oct factors and OCA-B, we propose a mechanism of action for OCA-B and discuss the implications of OCA-B for the transcriptional regulation of other tissue-specific promoters.
1	In	in	ADP	IN	_	_	_	_	_
2	light	light	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
7	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	OCA	OCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	action	action	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	OCA	OCA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	B	B	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	discuss	discuss	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	OCA	OCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
40	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
43	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
46	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3054
# text = Document 003003373 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003373	003003373	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3055
# text = Heterogeneity of antigen molecules recognized by anti-tax1 monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses.
1	Heterogeneity	Heterogeneity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	anti-tax1	anti-tax1	NUM	CD	NumType=Card	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
10	Lt	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
16	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
26	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3056
# text = Using a monoclonal antibody, Lt-4, directed against human T cell leukemia virus type I (HTLV-I) trans-activator (tax1) antigen, we examined the expression of tax1 and related antigens in a variety of T cell lines bearing HTLV-I and related retroviruses, simian T cell leukemia virus type I (STLV-I) and HTLV-II, by immunofluorescence and immunoblot assays. Lt-4 reacted with all HTLV-I-bearing cell lines tested and five out of eight simian cell lines bearing STLV-I, but not with an HTLV-II-bearing cell line.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
4	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Lt	Lt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	against	against	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	tax1	tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
33	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	tax1	tax1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
40	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
48	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
49	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
54	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
57	T	t	PROPN	NNP	Number=Sing	_	_	_	_
58	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
59	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
60	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
61	type	type	NOUN	NN	Number=Sing	_	_	_	_
62	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	STLV	STLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
66	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	_
68	and	and	CCONJ	CC	_	_	_	_	_
69	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	by	by	ADP	IN	_	_	_	_	_
74	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	immunoblot	immunoblot	ADV	RB	_	_	_	_	_
77	assays.	assays.	ADP	IN	_	_	_	_	_
78	Lt	Lt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
80	4	4	NUM	CD	NumType=Card	_	_	_	_
81	reacted	react	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
82	with	with	ADP	IN	_	_	_	_	_
83	all	all	DET	DT	_	_	_	_	_
84	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
85	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
86	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
87	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
88	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
89	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
90	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
91	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
92	and	and	CCONJ	CC	_	_	_	_	_
93	five	five	NUM	CD	NumType=Card	_	_	_	_
94	out	out	ADP	IN	_	_	_	_	_
95	of	of	ADP	IN	_	_	_	_	_
96	eight	eight	NUM	CD	NumType=Card	_	_	_	_
97	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
98	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
99	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
100	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
101	STLV	STLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
102	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
103	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
104	,	,	PUNCT	,	_	_	_	_	_
105	but	but	CCONJ	CC	_	_	_	_	_
106	not	not	ADV	RB	_	_	_	_	_
107	with	with	ADP	IN	_	_	_	_	_
108	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
109	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
110	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
111	II	II	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
112	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
113	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
114	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
115	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
116	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3057
# text = Lt-4 detected 40 kd tax1 antigen molecules in most HTLV-I-bearing cell lines except one cell line that expressed 39 kd tax1 antigen.
1	Lt	Lt	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	40	40	NUM	CD	NumType=Card	_	_	_	_
6	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
7	tax1	tax1	NUM	CD	NumType=Card	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
12	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	except	except	ADP	IN	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	39	39	NUM	CD	NumType=Card	_	_	_	_
26	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
27	tax1	tax1	NUM	CD	NumType=Card	_	_	_	_
28	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3058
# text = In the STLV-I-bearing T cell lines, tax1-related antigen molecules detected by Lt-4 were heterogeneous, having molecular weights in the range of 36-41 kd.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	STLV	Stlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
6	-bearing	-bear	VERB	VBG	VerbForm=Ger	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	tax1	tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
14	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Lt	Lt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
25	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
26	weights	weight	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	range	range	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	41	41	NUM	CD	NumType=Card	_	_	_	_
34	kd	k	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3059
# text = Document 003003375 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003375	003003375	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3060
# text = Cutting edge: TCR stimulation by antibody and bacterial superantigen induces Stat3 activation in human T cells.
1	Cutting	cut	NOUN	NN	Number=Sing	_	_	_	_
2	edge	edge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_
4	TCR	Tcr	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
10	superantigen	superantigen	NUM	CD	NumType=Card	_	_	_	_
11	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
12	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3061
# text = Recent data show that TCR/CD3 stimulation induces activation of Stat5 in murine T cells.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TCR/	TCR/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
6	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3062
# text = Here, we show that CD3 ligation by mAb and Staphylococcal enterotoxin (SE) induce a rapid, gradually accumulating, long-lasting tyrosine, and serine phosphorylation of Stat3 (but not Stat5) in allogen-specific human CD4+ T cell lines.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
7	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Staphylococcal	Staphylococcal	PROPN	NNP	Number=Sing	_	_	_	_
12	enterotoxin	enterotoxin	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	SE	SE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	gradually	gradually	ADV	RB	_	_	_	_	_
21	accumulating	accumulate	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	lasting	lasting	VERB	VBG	VerbForm=Ger	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	ADV	RB	_	_	_	_	_
36	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	allogen	allogen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	+	+	SYM	SYM	_	_	_	_	_
45	T	t	NUM	CD	NumType=Card	_	_	_	_
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3063
# text = In contrast, IL-2 induces a rapid and transient tyrosine and serine phosphorylation of Stat3.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3064
# text = Compared with IL-2, CD3 ligation induces a delayed Stat3 binding to oligonucleotide probes from the ICAM-1 and IL-2R alpha promoter.
1	Compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
8	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
9	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	_
12	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	oligonucleotide	oligonucleotide	VERB	VB	VerbForm=Inf	_	_	_	_
16	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3065
# text = CD3-mediated activation of Stat3 is almost completely inhibited by a Src kinase inhibitor (PP1), whereas IL-2-induced Stat3 activation is unaffected.
1	CD3	CD3	X	LS	_	_	_	_	SpaceAfter=No
2	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	almost	almost	ADV	RB	_	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Src	Src	PROPN	NNP	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	PP1	Pp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3066
# text = In conclusion, we show that CD3 ligation by mAb and SE triggers a rapid, PP1-sensitive tyrosine and serine phosphorylation of Stat3 in human CD4+ T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
8	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	SE	SE	PROPN	NNP	Number=Sing	_	_	_	_
13	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	rapid	rapid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	PP1	Pp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	T	t	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3067
# text = Moreover, we provide evidence that TCR/CD3 and IL-2 induce Stat3 activation via distinct signaling pathways.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	TCR/CD3	TCR/CD3	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
13	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	via	via	ADP	IN	_	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3068
# text = Document 003003378 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003378	003003378	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3069
# text = Anti-immunoglobulin
1	Anti-immunoglobulin	Anti-immunoglobulin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3070
# text = M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes.
1	M	m	NOUN	NN	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	calcium/calmodulin	calcium/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3071
# text = We and others have previously shown that the nuclear protein, Ets-1, is phosphorylated in a calcium-dependent manner after ligation of immunoglobulin
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	others	other	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3072
# text = (Ig) M on B lymphocytes.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	M	m	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3073
# text = As this phosphorylation was independent of protein kinase C activity, we tested whether a calcium/calmodulin-dependent protein kinase (CaM kinase) might phosphorylate the Ets-1 protein after elevation of intracellular free calcium concentrations.
1	As	as	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	C	C	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	whether	whether	SCONJ	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	calcium/calmodulin	calcium/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
26	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	after	after	ADP	IN	_	_	_	_	_
33	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
37	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
38	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3074
# text = The dephosphorylated form of Ets-1 has been shown to bind to chromatin, suggesting that the operative kinase should be detectable in the nucleus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	dephosphorylated	dephosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	operative	operative	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3075
# text = We prepared nuclear extracts from two human B cell lines in which increased intracellular free calcium levels correlated with increased phosphorylation of the Ets-1 protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	prepared	prepare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
15	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
16	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3076
# text = Activity of the CaM kinases was determined using a synthetic peptide substrate both in the absence and presence of an inhibitor specific for the CaM kinase family, KN-62.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	_
5	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	determined	determined	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
11	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
12	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	KN	KN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	62	62	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3077
# text = Stimulation of cells with anti-IgM led to increased activity of a nuclear kinase that could phosphorylate the peptide, and this activity was reduced by 10 microM KN-62.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anti-IgM	anti-Igm	NOUN	NN	Number=Sing	_	_	_	_
6	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	microM	microm	NUM	CD	NumType=Card	_	_	_	_
28	KN	KN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	62	62	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3078
# text = Kinase activity was reduced in lysates preadsorbed using an antibody specific for CaM kinase II.
1	Kinase	Kinase	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	preadsorbed	preadsor	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3079
# text = Two-dimensional phosphopeptide maps of the Ets-1 protein from cells incubated with ionomycin or anti-IgM contained two unique phosphopeptides that were absent in untreated cells.
1	Two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	dimensional	dimensional	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphopeptide	phosphopeptide	NOUN	NN	Number=Sing	_	_	_	_
5	maps	map	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
19	-IgM	-Igm	ADJ	JJ	Degree=Pos	_	_	_	_
20	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
23	phosphopeptides	phosphopeptide	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3080
# text = Incubation of isolated Ets-1 protein with purified CaM kinase II produced phosphorylation of peptides that migrated identically to those found in cells incubated with either anti-IgM or ionomycin.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	migrated	migrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	identically	identically	ADV	RB	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	either	either	CCONJ	CC	_	_	_	_	_
28	anti-IgM	anti-Igm	ADJ	JJ	Degree=Pos	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3081
# text = These data suggest a model of signal transduction by the antigen receptor on B lymphocytes in which increased intracellular free calcium can rapidly activate nuclear CaM kinase II, potentially resulting in phosphorylation and regulation of DNA-binding proteins.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
20	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
21	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	rapidly	rapidly	ADV	RB	_	_	_	_	_
24	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	potentially	potentially	ADV	RB	_	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3082
# text = Document 003003384 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003384	003003384	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3083
# text = Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
27	fluids	fluid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3084
# text = The balance between type 1 and 2 T helper cell cytokine production plays an important role in several animal models of autoimmunity, and skewed patterns of cytokine expression have been described in human inflammatory diseases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
19	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
20	models	model	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	skewed	skew	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3085
# text = Many cytokines activate signal transducer and activation of transcription (STAT) transcription factors, which, in turn, activate transcription of inflammatory effector genes.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
5	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3086
# text = We used mononuclear cell priming cultures and inflammatory synovial fluids (SFs) derived from arthritis patients to examine the regulation of cytokine production and STAT activity by an inflammatory synovial microenvironment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
6	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
10	fluids	fluid	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	SFs	Sfs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	arthritis	arthritis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
32	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3087
# text = Exposure to SFs during priming resulted in an 81% inhibition of interferon (IFN)-gamma, but not interleukin (IL) 4, production by effector cells generated in priming cultures.
1	Exposure	exposure	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	SFs	SF	VERB	VB	VerbForm=Inf	_	_	_	_
4	during	during	ADP	IN	_	_	_	_	_
5	priming	priming	NOUN	NN	Number=Sing	_	_	_	_
6	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	81	81	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	priming	priming	ADJ	JJ	Degree=Pos	_	_	_	_
35	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3088
# text = SF suppression was mediated by IL-4 and IL-10 and inhibition of IL-12 expression, and it was reversed in a dominant fashion by exogenous IL-12.
1	SF	SF	PROPN	NNP	Number=Sing	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	12	12	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
28	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
31	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3089
# text = SFs blocked the sustained activity of transcription factor Stat1, but not Stat3, during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production.
1	SFs	Sfs	NOUN	NNS	Number=Plur	_	_	_	_
2	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	priming	priming	ADJ	JJ	Degree=Pos	_	_	_	_
18	period	period	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Stat1	Stat1	NUM	CD	NumType=Card	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	differentially	differentially	ADV	RB	_	_	_	_	_
25	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
40	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3090
# text = Active Stat3, but not Stat1, was detected in cells from inflamed joints.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	joints	joint	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3091
# text = These results suggest a role for altered balance of Stat1 and Stat3 transcriptional activity in the regulation of T cell differentiation and in the pathogenesis of inflammatory synovitis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	synovitis	synovitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3092
# text = Document 003003386 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003386	003003386	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3093
# text = CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	but	but	CCONJ	CC	_	_	_	_	_
4	not	not	ADV	RB	_	_	_	_	_
5	lipopolysaccharide	lipopolysaccharide	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	anti-IgM	anti-igm	ADJ	JJ	Degree=Pos	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3094
# text = In this study we analyzed the effect of CD40 stimulation on the activity and nuclear appearance of Rel/nuclear factor kappaB (NF-kappaB) factors in primary murine B lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
31	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3095
# text = We show that triggering of CD40 signaling pathway(s) by CD40 ligands expressed on L cells led to strong activation of an NF-kappaB-controlled beta-globin reporter gene in primary B lymphocytes from transgenic mice.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
7	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	s	s	X	AFX	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
14	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
41	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3096
# text = Analyses of nuclear translocation of individual members of Rel proteins after CD40 induction of primary B cells showed a strong and long-lasting accumulation of RelB and, less pronounced, of c-Rel.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	members	member	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	lasting	lasting	VERB	VBG	VerbForm=Ger	_	_	_	_
25	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
31	pronounced	pronounce	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3097
# text = LPS stimulation did not give rise to a persistent nuclear accumulation of RelB and c-Rel, whereas nuclear c-Rel, but not RelB, accumulated after B cell receptor stimulation.
1	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	give	give	VERB	VB	VerbForm=Inf	_	_	_	_
6	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	after	after	ADP	IN	_	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3098
# text = CD40 induced not only nuclear translocation but also de novo synthesis of RelB RNA and protein.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	ADV	RB	_	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	de	de	X	FW	Foreign=Yes	_	_	_	_
10	novo	novo	ADJ	JJ	Degree=Pos	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
14	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3099
# text = S107 plasmacytoma cells, which express CD40 but are defective for the nuclear appearance of p50/p65-NF-kappaB, do not express RelB after CD40 stimulation.
1	S107	S107	NUM	CD	NumType=Card	_	_	_	_
2	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	DET	WDT	PronType=Int	_	_	_	_
6	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
7	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	p50/p65	p50/p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	do	do	AUX	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	express	express	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
25	RelB	RelB	NOUN	NN	Number=Sing	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3100
# text = In S107 cells stably transfected with relB genes, stimulation of nuclear
1	In	in	ADP	IN	_	_	_	_	_
2	S107	S107	NUM	CD	NumType=Card	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	stably	stably	ADV	RB	_	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	relB	relb	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3101
# text = RelB translocation by CD40 was observed.
1	RelB	Relb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3102
# text = These results indicate that stimulation of CD40 signaling pathways exerts a long-lasting stimulatory effect on both the transcription and nuclear translocation of RelB.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
8	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
10	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lasting	lasting	VERB	VBG	VerbForm=Ger	_	_	_	_
15	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3103
# text = Since LPS and anti-IgM were unable to activate RelB, CD40 appears to trigger a special program of gene expression involved in the proliferation and/or differentiation of B lymphocytes.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	anti-IgM	anti-IgM	ADJ	JJ	Degree=Pos	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	special	special	ADJ	JJ	Degree=Pos	_	_	_	_
17	program	program	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	or	or	CCONJ	CC	_	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3104
# text = Document 003003387 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003387	003003387	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3105
# text = Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock.
1	Temperature	temperature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
15	leucocyte	leucocyte	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
22	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3106
# text = OBJECTIVE: Activation of the hypothalamic-pituitary-adrenal axis is of vital importance during critical illness.
1	OBJECTIVE	objective	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
11	axis	axis	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	vital	vital	ADJ	JJ	Degree=Pos	_	_	_	_
15	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	illness	illness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3107
# text = We have studied the adaptive mechanisms which occur at the level of the glucocorticoid receptor in glucocorticoid target tissues in patients with sepsis or septic shock.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	adaptive	adaptive	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	target	target	NOUN	NN	Number=Sing	_	_	_	_
19	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
26	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3108
# text = DESIGN: The effects of hypercortisolaemia, hyperthermia and cellular composition on number of glucocorticoid receptors per cell and their affinity were evaluated, both in vitro and in vivo, in peripheral blood mononuclear leucocytes of control subjects and in patients with sepsis or septic shock.
1	DESIGN	Design	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	hypercortisolaemia	hypercortisolaemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	number	number	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
17	per	per	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
34	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
35	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	control	control	NOUN	NN	Number=Sing	_	_	_	_
39	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
45	or	or	CCONJ	CC	_	_	_	_	_
46	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
47	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3109
# text = SUBJECTS: Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit were studied.
1	SUBJECTS	sUBJECTs	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Fifteen	fifteen	NUM	CD	NumType=Card	_	_	_	_
4	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	age	age	NOUN	NN	Number=Sing	_	_	_	_
7	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	79	79	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
16	who	who	PRON	WP	PronType=Rel	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	admitted	admit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	intensive	intensive	ADJ	JJ	Degree=Pos	_	_	_	_
22	care	care	NOUN	NN	Number=Sing	_	_	_	_
23	unit	unit	NOUN	NN	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3110
# text = The control group consisted of 24 healthy laboratory employees.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	group	group	NOUN	NN	Number=Sing	_	_	_	_
4	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	24	24	NUM	CD	NumType=Card	_	_	_	_
7	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
8	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
9	employees	employee	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3111
# text = MEASUREMENTS:
1	MEASUREMENTS	Measurements	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3112
# text = The binding capacity and affinity of the glucocorticoid receptors were measured and compared to clinical data and the plasma cortisol concentrations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
16	data	data	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
20	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
21	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3113
# text = RESULTS: Hypercortisolaemia, in vitro, resulted in a decreased affinity and a decreased binding capacity of the glucocorticoid receptor.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Hypercortisolaemia	Hypercortisolaemia	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3114
# text = In vitro, hyperthermia as well as variations in the cellular composition did not influence the glucocorticoid receptor.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
5	as	as	ADV	RB	_	_	_	_	_
6	well	well	ADV	RB	Degree=Pos	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	variations	variation	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3115
# text = In vivo, there was no change in the number of receptors per cell in patients with sepsis or septic shock as compared to healthy controls.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	there	there	PRON	EX	_	_	_	_	_
5	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	change	change	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	number	number	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	per	per	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
21	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
26	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3116
# text = However, a decreased affinity of the glucocorticoid receptor was observed.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3117
# text = There was a weak but significant negative correlation between body temperature and the number of glucocorticoid receptors in the patient group.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	body	body	NOUN	NN	Number=Sing	_	_	_	_
11	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
21	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3118
# text = There was no relation between circulating cortisol concentrations and glucocorticoid receptor affinity and number.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	circulating	circulat	VERB	VBG	VerbForm=Ger	_	_	_	_
7	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
8	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3119
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3120
# text = There is no obvious regulation of the number of glucocorticoid receptors by plasma cortisol concentrations in vivo.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	obvious	obvious	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
14	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
15	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3121
# text = The decreased affinity of the glucocorticoid receptor together with the negative correlation between hyperthermia and the number of glucocorticoid receptors in patients with sepsis or septic shock suggest that hypothalamic-pituitary-adrenal axis activation during critical illness is accompanied by peripheral adaptation in glucocorticoid receptor number and affinity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	together	together	ADV	RB	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	number	number	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
27	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
35	axis	axis	NOUN	NN	Number=Sing	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	during	during	ADP	IN	_	_	_	_	_
38	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
39	illness	illness	NOUN	NN	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
44	adaptation	adaptation	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
48	number	number	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3122
# text = Document 003003388 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003388	003003388	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3123
# text = Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	peptidoglycan	peptidoglycan	ADJ	JJ	Degree=Pos	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	CD14	CD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3124
# text = Peptidoglycan (PGN), the major cell wall component of Gram-positive bacteria, induces secretion of cytokines in macrophages through CD14, the pattern recognition receptor that binds lipopolysaccharide and other microbial products.
1	Peptidoglycan	Peptidoglycan	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	PGN	PGN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Gram-	Gram-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
14	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	pattern	pattern	ADJ	JJ	Degree=Pos	_	_	_	_
27	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
35	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3125
# text = To begin to elucidate the mechanisms that regulate the transcription of cytokine genes, we wanted to determine which transcription factors are activated by PGN in mouse RAW264.7 and human THP-1 macrophage cells.
1	To	to	PART	TO	_	_	_	_	_
2	begin	begin	VERB	VB	VerbForm=Inf	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	wanted	want	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
19	which	which	DET	WDT	PronType=Int	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	PGN	Pgn	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
28	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3126
# text = Our results demonstrated that: (i) PGN induced phosphorylation of the transcription factors ATF-1 and CREB; (ii) ATF-1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid, which was inhibited by dominant negative CREB and ATF-1; (iii) PGN induced phosphorylation of c-Jun, protein synthesis of JunB and c-Fos, and transcriptional activation of the AP-1 reporter plasmid, which was inhibited by dominant negative c-Fos; and (iv) PGN-induced activation of CREB/ATF and AP-1 was mediated through CD14.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	i	i	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	PGN	Pgn	ADP	IN	_	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	ATF	ATF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
30	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	CRE	CRE	ADJ	JJ	Degree=Pos	_	_	_	_
42	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
43	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	which	which	PRON	WDT	PronType=Rel	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
50	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
51	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	ATF	Atf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	;	;	PUNCT	,	_	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	_
60	PGN	Pgn	ADP	IN	_	_	_	_	_
61	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
69	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
70	of	of	ADP	IN	_	_	_	_	_
71	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
72	and	and	CCONJ	CC	_	_	_	_	_
73	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
74	Fos	Fo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	and	and	CCONJ	CC	_	_	_	_	_
77	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
78	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
79	of	of	ADP	IN	_	_	_	_	_
80	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
81	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
83	1	1	NUM	CD	NumType=Card	_	_	_	_
84	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
85	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
86	,	,	PUNCT	,	_	_	_	_	_
87	which	which	PRON	WDT	PronType=Rel	_	_	_	_
88	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
89	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
90	by	by	ADP	IN	_	_	_	_	_
91	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
92	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
93	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
94	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
95	;	;	PUNCT	,	_	_	_	_	_
96	and	and	CCONJ	CC	_	_	_	_	_
97	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
98	iv	iv	X	ADD	_	_	_	_	SpaceAfter=No
99	)	)	PUNCT	-RRB-	_	_	_	_	_
100	PGN	Pgn	ADP	IN	_	_	_	_	SpaceAfter=No
101	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
102	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
103	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
104	of	of	ADP	IN	_	_	_	_	_
105	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
106	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
107	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
108	and	and	CCONJ	CC	_	_	_	_	_
109	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
110	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
111	1	1	NUM	CD	NumType=Card	_	_	_	_
112	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
113	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
114	through	through	ADP	IN	_	_	_	_	_
115	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
116	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
117	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3127
# text = This is the first study to demonstrate activation of CREB/ATF and AP-1 transcription factors by PGN or by any other component of Gram-positive bacteria.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	PGN	PGN	PROPN	NNP	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	any	any	DET	DT	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	component	component	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Gram-	Gram-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3128
# text = Document 003003389 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003389	003003389	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3129
# text = Nonradioactive quantification of glucocorticoid receptor expression during differentiation of human monocytic cells (U937).
1	Nonradioactive	Nonradioactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	quantification	quantification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3130
# text = We describe a method for relative quantification of specific mRNA using a nonradioactive assay based on DNA strand competition between identical sequences of biotin- and fluorescein-labeled amplicon (probe) and unlabeled amplicon (target) during hybridization.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	method	method	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
7	quantification	quantification	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	nonradioactive	nonradioactive	ADJ	JJ	Degree=Pos	_	_	_	_
14	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
15	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
18	strand	strand	NOUN	NN	Number=Sing	_	_	_	_
19	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
20	between	between	ADP	IN	_	_	_	_	_
21	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
22	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	biotin	biotin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	fluorescein	fluorescein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	amplicon	amplicon	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	unlabeled	unlabel	ADJ	JJ	Degree=Pos	_	_	_	_
36	amplicon	amplicon	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	target	target	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	during	during	ADP	IN	_	_	_	_	_
41	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3131
# text = As the target quantity increased, that of the double-labeled probe decreased in accordance with the mass action law.
1	As	as	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	target	target	NOUN	NN	Number=Sing	_	_	_	_
4	quantity	quantity	NOUN	NN	Number=Sing	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	accordance	accordance	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mass	mass	ADJ	JJ	Degree=Pos	_	_	_	_
20	action	action	NOUN	NN	Number=Sing	_	_	_	_
21	law	law	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3132
# text = This technique was successfully applied to evaluate differences in glucocorticoid receptor expression in U937 cells before and after the addition of potent differentiation inducers: 12-O-tetradecanoylphorbol 13-acetate (TPA) and a combination of all-trans retinoic acid (RA) and 1,25-dihydroxyvitamin D2 (VD).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	successfully	successfully	ADV	RB	_	_	_	_	_
5	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	before	before	ADV	RB	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	:	:	PUNCT	:	_	_	_	_	_
26	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-O	-o	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
30	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
32	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	all	all	DET	DT	_	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
43	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
44	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
52	D2	d2	NOUN	NN	Number=Sing	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	VD	VD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3133
# text = We observed that TPA treatment was associated with an increase in specific binding of [3H]dexamethasone and up-regulation of GR mRNA while no enhanced GR expression was perceived with RA/VD treatment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	H]	h]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
25	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
26	while	while	SCONJ	IN	_	_	_	_	_
27	no	no	DET	DT	_	_	_	_	_
28	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	perceived	perceive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	VD	Vd	ADJ	JJ	Degree=Pos	_	_	_	_
37	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3134
# text = Document 003003390 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003390	003003390	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3135
# text = Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells.
1	Alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
2	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3136
# text = The transcription factor NF-ATc is synthesized in three prominent isoforms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
12	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3137
# text = These differ in the length of their C terminal peptides and mode of synthesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	differ	differ	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	length	length	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	C	c	X	GW	_	_	_	_	_
9	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
10	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3138
# text = Due to a switch from the use of a 3' polyA site to a more proximal polyA site, NF-ATc expression switches from the synthesis of the two longer isoforms in naive T cells to that of short isoform A in T effector cells.
1	Due	due	ADP	IN	_	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	use	use	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	``	_	_	_	_	_
12	polyA	polya	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	more	more	ADV	RBR	_	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	polyA	polya	NOUN	NN	Number=Sing	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	switches	switche	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	longer	longer	ADJ	JJ	Degree=Pos	_	_	_	_
33	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
42	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
43	A	a	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3139
# text = The relative low binding affinity of cleavage stimulation factor CstF-64 to the proximal polyA site seems to contribute to its neglect in naive T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
3	low	low	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	CstF	CstF	ADP	IN	_	_	_	_	SpaceAfter=No
11	-64	-64	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
15	polyA	polya	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	neglect	neglect	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3140
# text = These alternative polyadenylation events ensure the rapid accumulation of high concentrations of NF-ATc necessary to exceed critical threshold levels of NF-ATc for gene induction in effector T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
3	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	ensure	ensure	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
8	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
11	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
16	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	exceed	exceed	VERB	VB	VerbForm=Inf	_	_	_	_
19	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
20	threshold	threshold	NOUN	NN	Number=Sing	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3141
# text = Document 003003392 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003392	003003392	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3142
# text = Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
5	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	HT	HT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
19	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
20	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3143
# text = Nuclear factor of activated T cells (NFAT) regulates transcription of a number of cytokine genes, and NFAT DNA binding activity is stimulated following T cell activation.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NFAT	Nfat	SCONJ	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3144
# text = Several lines of evidence have suggested that NFAT is a substrate for calcineurin, a serine/threonine phosphatase.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NFAT	Nfat	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	calcineurin	calcineurin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3145
# text = Using a polyclonal antibody to murine NFATp, Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
4	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	murine	murine	VERB	VB	VerbForm=Inf	_	_	_	_
7	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
10	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
11	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
14	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
15	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
16	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	110-	110-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	130	130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-kDa	-kDa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3146
# text = NFATp protein was highly expressed in thymus and spleen.
1	NFATp	NFATp	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	highly	highly	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3147
# text = Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp, demonstrating that NFATp is an in vitro substrate for calcineurin.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	immunoprecipitated	immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
7	HT	HT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
13	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
27	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3148
# text = NFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells.
1	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
2	immunoprecipitated	immunoprecipitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	32P	32p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	HT	Ht	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	migrated	migrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	120	120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3149
# text = Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of NFATp and a loss of 32P, consistent with NFATp dephosphorylation.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
7	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
14	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
27	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3150
# text = The dephosphorylation of NFATp was accompanied by localization of the protein to the nuclear fraction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3151
# text = Both of these events were blocked by preincubation of the cells with FK506, a calcineurin inhibitor, consistent with the hypothesis that NFATp is a calcineurin substrate in cells.
1	Both	both	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
28	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3152
# text = Document 003003398 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003398	003003398	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3153
# text = p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.
1	p105	p105	NUM	CD	NumType=Card	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	p98	p98	NUM	CD	NumType=Card	_	_	_	_
4	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3154
# text = The Rel/NF-kappa B family of transcription factors is composed of two distinct subgroups, proteins that undergo proteolytic processing and contain SWI6/ankyrin repeats in their carboxyl termini (p105, p98), and those without such repeats that do not require processing (p65, c-Rel, RelB, and Dorsal).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Rel/	rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
16	subgroups	subgroup	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	undergo	undergo	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
25	SWI6	SWI6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	ankyrin	ankyrin	ADP	IN	_	_	_	_	_
28	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
32	termini	termini	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	p98	p98	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
41	without	without	ADP	IN	_	_	_	_	_
42	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
43	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	not	not	PART	RB	_	_	_	_	_
47	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
48	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	Dorsal	Dorsal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3155
# text = We demonstrate that the p105 and p98 precursors share functional properties with the I kappa B proteins, which also contain SWI6/ankyrin repeats.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p98	p98	NUM	CD	NumType=Card	_	_	_	_
8	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
9	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	I	I	ADJ	JJ	Degree=Pos	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	SWI6	Swi6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
25	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3156
# text = Both p105 and p98 were found to form stable complexes with other Rel/NF-kappa B family members, including p65 and c-Rel.
1	Both	both	DET	DT	_	_	_	_	_
2	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	p98	p98	NUM	CD	NumType=Card	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
9	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
10	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3157
# text = Association with the precursors is sufficient for cytoplasmic retention of either p65 or c-Rel, both of which are otherwise nuclear.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	retention	retention	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	otherwise	otherwise	ADV	RB	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3158
# text = These complexes undergo stimulus-responsive processing to produce active p50/c-Rel and p55/c-Rel complexes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	undergo	undergo	ADV	RB	_	_	_	_	_
4	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
7	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
10	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
11	p50/c	p50/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p55/c	p55/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
18	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3159
# text = These observations suggest a second pathway leading to NF-kappa B induction, in which processing of the precursors rather than phosphorylation of I kappa B plays a major role.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
7	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
21	rather	rather	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	B	PROPN	NNP	Number=Sing	_	_	_	_
28	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3160
# text = Document 003003399 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003399	003003399	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3161
# text = IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	tyk2	tyk2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
15	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
21	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3162
# text = IL-10 affects monocytes and T cells by driving the progression of immune responsiveness such that Th2 lymphocyte-mediated effects predominate.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	affects	affect	NOUN	NNS	Number=Plur	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	driving	drive	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
19	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	predominate	predominate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3163
# text = In this report, we show that in monocytes and T cells IL-10 stimulates tyrosine phosphorylation of the signal transducers and activators of transcription, STAT1 alpha and STAT3, in a differential manner such that the relative formation of homo- and heterodimers varies between the two cell types.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	T	t	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	10	10	NUM	CD	NumType=Card	_	_	_	_
16	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
22	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
36	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
37	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
38	that	that	SCONJ	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
41	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
47	varies	varies	NOUN	NNS	Number=Plur	_	_	_	_
48	between	between	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	two	two	NUM	CD	NumType=Card	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3164
# text = Moreover, monocytes express a novel IL-10-stimulated STAT protein with an M(r) of 70 kDa that is recognized by the anti-STAT3
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	r	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	70	70	NUM	CD	NumType=Card	_	_	_	_
22	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	anti-STAT3	anti-STAT3	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3165
# text = Ab but is not observed in T cells.
1	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	_
2	but	but	CCONJ	CC	_	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3166
# text = IL-10 treatment of both T cells and monocytes results in the ligand-induced tyrosine phosphorylation of tyk2 and Jak1, but not Jak2 or Jak3.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	results	result	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	tyk2	tyk2	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	Jak2	Jak2	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3167
# text = Selective modulation of immune responsiveness by IL-10 in cells such as monocytes and T cells may result in part from the differential activation of
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
5	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	part	part	NOUN	NN	Number=Sing	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_

# sent_id = 3168
# text = STAT protein pairs.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3169
# text = Document 003003405 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003405	003003405	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3170
# text = Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer.
1	Impaired	Impaired	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	DQ2	Dq2	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	DQ8	Dq8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	HSV	Hsv	PROPN	NNP	Number=Sing	_	_	_	_
11	VP	vp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	16	16	NUM	CD	NumType=Card	_	_	_	_
13	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	DQA1*0501/DQB1*	DQA1*0501/DQB1*	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	0302	0302	NUM	CD	NumType=Card	_	_	_	_
18	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3171
# text = DQalpha and DQbeta trans heterodimeric HLA-DQ molecules form in individuals heterozygous for the DQ2 and DQ8 specificities.
1	DQalpha	DQalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	DQbeta	DQbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	trans	tran	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
6	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	form	from	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
13	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DQ2	Dq2	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	DQ8	DQ8	NOUN	NN	Number=Sing	_	_	_	_
19	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3172
# text = Unique functions and disease associations have been postulated for such trans-dimers, which may be different from cis-encoded DQ molecules encoded by the corresponding haplotypes.
1	Unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
5	associations	association	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	-encoded	-encod	ADJ	JJ	Degree=Pos	_	_	_	_
22	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
28	haplotypes	haplotype	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3173
# text = We analyzed the ability of the trans-dimer encoded by HLA-DQA1*0501/DQB1*0302 to bind a peptide antigen which interacts with DQ molecules encoded by both parental haplotypes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
10	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	DQA1*0501/DQB	DQA1*0501/DQB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	1*0302	1*0302	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
20	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
25	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
26	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
30	haplotypes	haplotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3174
# text = Markedly impaired binding was observed, consistent with both the use of different anchor residues and with changes in levels of DQ cis-dimer availability for peptide binding interactions.
1	Markedly	markedly	ADV	RB	_	_	_	_	_
2	impaired	impaire	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	use	use	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
14	anchor	anchor	NOUN	NN	Number=Sing	_	_	_	_
15	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
23	cis-dimer	cis-dimer	NOUN	NN	Number=Sing	_	_	_	_
24	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3175
# text = Document 003003411 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003411	003003411	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3176
# text = Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	type	type	NOUN	NN	Number=Sing	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3177
# text = L-selectin is an adhesion molecule of the selectin family that mediates the initial step of leukocyte adhesion to vascular endothelium.
1	L-	L-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
15	step	step	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
21	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3178
# text = Upon cellular activation, expression of the L-selectin gene is downregulated at both the protein and mRNA levels.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3179
# text = To understand the mechanism of leukemic cell infiltration into organs, we studied the expression and regulation of L-selectin mRNA in fresh leukemic cells of adult T-cell leukemia (ATL) patients and investigated the response of the L-selectin promoter to human T-cell lymphotropic virus type 1 (HTLV-1) Tax, which is a viral transcriptional transactivator.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	ATL	ATL	INTJ	UH	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	response	response	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
49	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
50	type	type	NOUN	NN	Number=Sing	_	_	_	_
51	1	1	NUM	CD	NumType=Card	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	which	which	PRON	WDT	PronType=Rel	_	_	_	_
60	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
61	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
63	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
64	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3180
# text = Flow cytometry showed that L-selectin was expressed on fresh ATL cells along with other activation antigens.
1	Flow	Flow	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
11	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	along	along	ADP	IN	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3181
# text = Northern blot analysis showed that ATL cells overexpressed that L-selectin mRNA and that the level was aberrantly upregulated after PMA stimulation.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	ATL	Atl	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	overexpressed	overexpress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	L-	L-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
12	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	aberrantly	aberrantly	ADV	RB	_	_	_	_	_
19	upregulated	upregulated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3182
# text = Studies using in situ hybridization showed expression of the L-selectin mRNA in the infiltrating leukemic cells in the liver of two ATL patients.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
5	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	infiltrating	infiltrating	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
24	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3183
# text = Intravenous injection of a rat T-cell line that overexpresses L-selectin showed increased organ infiltration.
1	Intravenous	Intravenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	injection	injection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
6	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	overexpresses	overexpress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	L-	L-	X	GW	_	_	_	_	SpaceAfter=No
12	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
13	showed	showed	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
16	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3184
# text = The induction of Tax expression in JPX9 cells resulted in about a twofold increase in the mRNA expression levels compared with the basal level.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	JPX9	JPX9	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	about	about	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	twofold	twofold	NOUN	NN	Number=Sing	_	_	_	_
14	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3185
# text = Chloramphenicol acetyltransferase (CAT) assay after transient cotransfection showed about a fivefold transactivation of the L-selectin promoter by Tax.
1	Chloramphenicol	Chloramphenicol	PROPN	NNP	Number=Sing	_	_	_	_
2	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
7	after	after	ADP	IN	_	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	about	about	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	fivefold	fivefold	NOUN	NN	Number=Sing	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3186
# text = The serum level of the shed form of L-selectin was significantly increased in ATL patients (mean +/- SD, 4,215.4 +/- 4,111 ng/mL) compared with those of asymptomatic carriers and healthy blood donors (mean +/- SD, 1,148.0 +/- 269.0 ng/mL and 991.9 +/- 224 ng/mL, respectively).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
3	level	level	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	shed	shed	ADJ	JJ	Degree=Pos	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	significantly	significantly	ADV	RB	_	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	ATL	Atl	PROPN	NNP	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	mean	mean	X	GW	_	_	_	_	_
19	+/-	+/-	X	GW	_	_	_	_	_
20	SD	sd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	4,215.4	4,215.4	NUM	CD	NumType=Card	_	_	_	_
23	+/-	+/-	SYM	SYM	_	_	_	_	_
24	4,111	4,111	NUM	CD	NumType=Card	_	_	_	_
25	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	mL	mL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	asymptomatic	asymptomatic	ADJ	JJ	Degree=Pos	_	_	_	_
34	carriers	carrier	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
37	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
38	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	mean	mean	X	GW	_	_	_	_	_
41	+/-	+/-	X	GW	_	_	_	_	_
42	SD	SD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	1,148.0	1,148.0	NUM	CD	NumType=Card	_	_	_	_
45	+/-	+/-	SYM	SYM	_	_	_	_	_
46	269.0	269.0	NUM	CD	NumType=Card	_	_	_	_
47	ng/mL	ng/mL	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	991.9	991.9	NUM	CD	NumType=Card	_	_	_	_
50	+/-	+/-	SYM	SYM	_	_	_	_	_
51	224	224	NUM	CD	NumType=Card	_	_	_	_
52	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
54	mL	mL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3187
# text = These results indicated that ATL cells constitutively overexpress the L-selectin gene that can be transactivated by HTLV-1 Tax.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	overexpress	overexpress	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3188
# text = The overexpression of L-selectin, as well as of inflammatory cytokines, by ATL cells may provide a basis for ATL cells to attach the vascular endothelium, leading to transmigration and organ infitration.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	attach	attach	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
28	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	transmigration	transmigration	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
35	infitration	infitration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3189
# text = Document 003003414 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003414	003003414	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3190
# text = Nonopsonic phagocytosis of Pseudomonas aeruginosa by macrophages and polymorphonuclear leukocytes requires the presence of the bacterial flagellum.
1	Nonopsonic	Nonopsonic	ADJ	JJ	Degree=Pos	_	_	_	_
2	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Pseudomonas	Pseudomonas	PROPN	NNP	Number=Sing	_	_	_	_
5	aeruginosa	aeruginosa	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
17	flagellum	flagellum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3191
# text = Whereas the mechanism of nonopsonic phagocytosis of Pseudomonas aeruginosa has been described, the bacterial ligands required are poorly understood.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nonopsonic	nonopsonic	ADJ	JJ	Degree=Pos	_	_	_	_
6	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Pseudomonas	Pseudomonas	PROPN	NNP	Number=Sing	_	_	_	_
9	aeruginosa	aeruginosa	PROPN	NNP	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
16	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	poorly	poorly	ADV	RB	_	_	_	_	_
20	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3192
# text = To identify the requisite bacterial ligands, studies with isogenic mutants of P. aeruginosa PAK lacking pili, flagella, and the RpoN sigma factor were undertaken.
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	requisite	requisite	NOUN	NN	Number=Sing	_	_	_	_
5	bacterial	bacterial	NOUN	NN	Number=Sing	_	_	_	_
6	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	isogenic	isogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	P.	P.	NOUN	NN	Number=Sing	_	_	_	_
14	aeruginosa	aeruginosa	NOUN	NN	Number=Sing	_	_	_	_
15	PAK	Pak	NOUN	NN	Number=Sing	_	_	_	_
16	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
17	pili	pili	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	flagella	flagella	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	RpoN	RpoN	ADJ	JJ	Degree=Pos	_	_	_	_
24	sigma	sigma	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3193
# text = The RpoN mutant, lacking pili, flagella, and nonpilus adhesins, bound poorly and was resistant to ingestion by both macrophages and neutrophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	RpoN	RpoN	PROPN	NNP	Number=Sing	_	_	_	_
3	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
6	pili	pili	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	flagella	flagella	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nonpilus	nonpilus	ADJ	JJ	Degree=Pos	_	_	_	_
12	adhesins	adhesin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
15	poorly	poorly	ADV	RB	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	ingestion	ingestion	VERB	VB	VerbForm=Inf	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3194
# text = Pili were not absolutely required for binding or phagocytosis of P.
1	Pili	Pili	NOUN	NN	Number=Sing	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	absolutely	absolutely	ADV	RB	_	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	for	for	SCONJ	IN	_	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	P.	P.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3195
# text = aeruginosa.
1	aeruginosa	aeruginosa	INTJ	UH	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3196
# text = The presence of a flagellum was not required for binding of P. aeruginosa to macrophages but was critical for the subsequent internalization of the bacterium, suggesting that this factor or a surface ligand associated with its assembly was responsible for stimulation of nonopsonic phagocytosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	flagellum	flagellum	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	P.	P.	NOUN	NN	Number=Sing	_	_	_	_
13	aeruginosa	aeruginosa	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
22	internalization	internalization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	bacterium	bacterium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
34	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
35	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	nonopsonic	nonopsonic	ADJ	JJ	Degree=Pos	_	_	_	_
45	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3197
# text = Document 003003415 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003415	003003415	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3198
# text = Synergistic interactions between overlapping binding sites for the serum response factor and ELK-1 proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus major immediate-early promoters in monocyte and T-lymphocyte cell types.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	overlapping	overlapp	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	ELK	elk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
20	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
23	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
24	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	primate	primate	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
28	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
29	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
32	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3199
# text = Cytomegalovirus (CMV) infection is nonpermissive or persistent in many lymphoid and myeloid cell types but can be activated in differentiated macrophages.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	nonpermissive	nonpermissive	ADJ	JJ	Degree=Pos	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	types	type	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3200
# text = We have shown elsewhere that both the major immediate-early gene (MIE) and lytic cycle infectious progeny virus expression can be induced in otherwise nonpermissive monocyte-like U-937 cell cultures infected with either human CMV (HCMV) or simian CMV (SCMV) by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	elsewhere	elsewhere	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MIE	MIE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
19	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
20	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	otherwise	otherwise	ADV	RB	_	_	_	_	_
28	nonpermissive	nonpermissive	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-like	-like	ADP	IN	_	_	_	_	_
31	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	937	937	NUM	CD	NumType=Card	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
36	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	either	either	DET	DT	_	_	_	_	_
39	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
40	CMV	Cmv	PROPN	NNP	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
46	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
52	with	with	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
55	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
56	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
58	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
59	-tetradecanoylphorbol	-tetradecanoylphorbol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
60	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
61	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
62	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
63	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3201
# text = Two multicopy basal enhancer motifs within the SCMV MIE enhancer, namely, 11 copies of the 16-bp cyclic AMP response element (CRE) and 3 copies of novel 17-bp serum response factor (SRF) binding sites referred to as the SNE (SRF/NFkappaB-like element), as well as four classical NFkappaB sites within the HCMV version, contribute to TPA responsiveness in transient assays in monocyte and T-cell types.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	multicopy	multicopy	ADJ	JJ	Degree=Pos	_	_	_	_
3	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	_
9	MIE	MIE	PROPN	NNP	Number=Sing	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	namely	namely	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	11	11	NUM	CD	NumType=Card	_	_	_	_
15	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	cyclic	cyclic	NOUN	NN	Number=Sing	_	_	_	_
22	AMP	Amp	SYM	NFP	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CRE	CRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	3	3	NUM	CD	NumType=Card	_	_	_	_
30	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
33	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
36	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
37	response	response	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	SRF	SRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
43	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
44	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	as	as	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	SNE	SNE	PROPN	NNP	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
55	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	as	as	ADV	RB	_	_	_	_	_
59	well	well	ADV	RB	Degree=Pos	_	_	_	_
60	as	as	ADP	IN	_	_	_	_	_
61	four	four	NUM	CD	NumType=Card	_	_	_	_
62	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
63	NFkappaB	Nfkappab	NOUN	NN	Number=Sing	_	_	_	_
64	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
65	within	within	ADP	IN	_	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	_
68	version	version	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
71	to	to	ADP	IN	_	_	_	_	_
72	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
73	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
74	in	in	ADP	IN	_	_	_	_	_
75	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
76	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
77	in	in	ADP	IN	_	_	_	_	_
78	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
79	and	and	CCONJ	CC	_	_	_	_	_
80	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
82	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
83	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3202
# text = The SCMV SNE sites contain potential overlapping core recognition binding motifs for SRF, Rel/NFkappaB, ETS, and YY1 class transcription factors but fail to respond to either serum or tumor necrosis factor alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	_
3	SNE	SNE	PROPN	NNP	Number=Sing	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
7	overlapping	overlapp	NOUN	NN	Number=Sing	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Rel/	Rel/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	ETS	Ets	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	YY1	YY1	NUM	CD	NumType=Card	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	either	either	CCONJ	CC	_	_	_	_	_
31	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
34	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3203
# text = Therefore, to evaluate the mechanism of TPA responsiveness of the SNE motifs and of a related 16-bp SEE (SRF/ETS element) motif found in the HCMV and chimpanzee CMV MIE enhancers, we have examined the functional responses and protein binding properties of multimerized wild-type and mutant elements added upstream to the SCMV MIE or simian virus 40 minimal promoter regions in the U-937, K-562, HL-60, THP-1, and Jurkat cell lines.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	SNE	Sne	ADJ	JJ	Degree=Pos	_	_	_	_
13	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
18	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	SEE	See	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	SRF	SRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
29	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	chimpanzee	chimpanzee	PROPN	NNP	Number=Sing	_	_	_	_
35	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
36	MIE	MIE	PROPN	NNP	Number=Sing	_	_	_	_
37	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
44	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
47	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
48	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	type	type	NOUN	NN	Number=Sing	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
56	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
57	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
59	to	to	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	_
62	MIE	MIE	PROPN	NNP	Number=Sing	_	_	_	_
63	or	or	CCONJ	CC	_	_	_	_	_
64	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
65	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
66	40	40	NUM	CD	NumType=Card	_	_	_	_
67	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
68	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
69	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
70	in	in	ADP	IN	_	_	_	_	_
71	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
72	U-	u-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
74	,	,	PUNCT	,	_	_	_	_	_
75	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
76	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
77	562	562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
78	,	,	PUNCT	,	_	_	_	_	_
79	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
80	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
81	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
84	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
85	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
86	,	,	PUNCT	,	_	_	_	_	_
87	and	and	CCONJ	CC	_	_	_	_	_
88	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
89	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
90	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
91	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3204
# text = Unlike classical NFkappaB sites, neither the SNE nor the SEE motif responded to phosphatase inhibition by okadaic acid.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
3	NFkappaB	Nfkappab	NOUN	NN	Number=Sing	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	neither	neither	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	SNE	Sne	NOUN	NN	Number=Sing	_	_	_	_
9	nor	nor	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	SEE	see	ADJ	JJ	Degree=Pos	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
13	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	phosphatase	phosphatase	VERB	VB	VerbForm=Inf	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
19	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3205
# text = However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
5	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	proved	prove	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
13	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
14	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	core	core	NOUN	NN	Number=Sing	_	_	_	_
18	SRF	Srf	SCONJ	IN	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CCATATATGG	CCATATATGG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
27	inverted	invert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	ETS	ets	NOUN	NNS	Number=Plur	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TTCC	TTCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	directly	directly	ADV	RB	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
43	tripartite	tripartite	ADJ	JJ	Degree=Pos	_	_	_	_
44	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
45	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
46	both	both	CCONJ	CC	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
49	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	ELK	elk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3206
# text = This protein complex was more abundant in U-937, K-562, and HeLa cell extracts than in Raji, HF, BALB/c 3T3, or HL-60 cells, but the binding activity was altered only twofold after TPA treatment.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	more	more	ADV	RBR	_	_	_	_	_
6	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	562	562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
19	extracts	extract	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	HF	HF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	BALB	BALB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	c	c	NOUN	NN	Number=Sing	_	_	_	_
29	3T3	3T3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	60	60	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	only	only	ADV	RB	_	_	_	_	_
44	twofold	twofold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	after	after	ADP	IN	_	_	_	_	_
46	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3207
# text = A 40-fold stimulation of chloramphenicol acetyltransferase activity mediated by four tandem repeats of the SNE could be induced within 2 h (and up to 250-fold within 6 h) after addition of TPA in DNA-transfected U-937 cells, indicating that the stimulation appeared likely to be a true protein kinase C-mediated signal transduction event rather than a differentiation response.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
8	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	four	four	NUM	CD	NumType=Card	_	_	_	_
13	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
14	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	SNE	Sne	PROPN	NNP	Number=Sing	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	h	h	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	and	and	CCONJ	CC	_	_	_	_	_
26	up	up	ADV	RB	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	250	250	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
31	within	within	ADP	IN	_	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	937	937	NUM	CD	NumType=Card	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
49	that	that	SCONJ	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
52	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	likely	likely	ADV	RB	_	_	_	_	_
54	to	to	PART	TO	_	_	_	_	_
55	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
56	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
57	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
58	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
59	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
60	C-	C-	PUNCT	:	_	_	_	_	SpaceAfter=No
61	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
63	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
64	event	event	NOUN	NN	Number=Sing	_	_	_	_
65	rather	rather	ADV	RB	_	_	_	_	_
66	than	than	ADP	IN	_	_	_	_	_
67	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
68	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
69	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3208
# text = Slight differences in the sequence of the core SRF binding site compared with that of the classical c-Fos promoter serum response element, together with differences in the spacing between the SRF and ETS motifs, appear to account for the inability of the SCMV SNEs to respond to serum induction.
1	Slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	SRF	SRF	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	together	together	ADV	RB	_	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	spacing	spacing	NOUN	NN	Number=Sing	_	_	_	_
32	between	between	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	SRF	Srf	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	ETS	ets	NOUN	NN	Number=Sing	_	_	_	_
37	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	_
48	SNEs	SNEs	PROPN	NNP	Number=Sing	_	_	_	_
49	to	to	PART	TO	_	_	_	_	_
50	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
53	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3209
# text = Document 003003417 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003417	003003417	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3210
# text = Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
9	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	negatively	negatively	ADV	RB	_	_	_	_	_
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B2	b2	NUM	CD	NumType=Card	_	_	_	_
21	p100	p100	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	:	:	PUNCT	:	_	_	_	_	_
25	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3211
# text = Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of the adult T-cell leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
20	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	aggressive	aggressive	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	often	often	ADV	RB	_	_	_	_	_
28	fatal	fatal	ADJ	JJ	Degree=Pos	_	_	_	_
29	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3212
# text = HTLV-I encodes an essential 40-kDa protein termed Tax that not only transactivates the long terminal repeat of this retrovirus but also induces an array of cellular genes.
1	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
19	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
20	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	array	array	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3213
# text = Tax-mediated transformation of T cells likely involves the deregulated expression of various cellular genes that normally regulate lymphocyte growth produced by altered activity of various endogenous host transcription factors.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	likely	likely	ADV	RB	_	_	_	_	_
9	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	deregulated	deregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	normally	normally	ADV	RB	_	_	_	_	_
19	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
22	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
28	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
29	host	host	NOUN	NN	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3214
# text = In particular, Tax is capable of modulating the expression or activity of various host transcription factors, including members of the NF-kappa B/Rel and CREB/ATF families, as well as the cellular factors HEB-1 and p67SRF.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	SCONJ	IN	_	_	_	_	_
8	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	host	host	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
33	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	as	as	ADV	RB	_	_	_	_	_
36	well	well	ADV	RB	Degree=Pos	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
41	HEB	HEB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	p67SRF	p67srf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3215
# text = An additional distinguishing characteristic of HTLV-I infection is the profound state of viral latency that is present in circulating primary leukemic T cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	distinguishing	distinguishing	ADJ	JJ	Degree=Pos	_	_	_	_
4	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
13	state	state	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	SCONJ	IN	_	_	_	_	_
21	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3216
# text = In this study, we demonstrate that HTLV-I Tax can physically associate with p100, the product of the Rel-related NF-kappa B2 gene, both in transfected cells and in HTLV-I-infected leukemic T-cell lines.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	physically	physically	ADV	RB	_	_	_	_	_
14	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	product	product	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Rel-	rel-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	transfected	transfected	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3217
# text = Furthermore, the physical interaction of Tax with p100 leads to the inhibition of Tax-induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats, reflecting p100-mediated cytoplasmic sequestration of the normally nuclearly expressed Tax protein.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	p100	p100	NUM	CD	NumType=Card	_	_	_	_
10	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
27	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
31	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
32	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	reflecting	reflect	VERB	VBG	VerbForm=Ger	_	_	_	_
35	p100	p100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
39	sequestration	sequestration	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	normally	normally	ADV	RB	_	_	_	_	_
43	nuclearly	nuclearly	ADV	RB	_	_	_	_	_
44	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
46	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3218
# text = In contrast, a mutant of Tax that selectively fails to activate nuclear NF-kappa B expression does not associate with p100.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3219
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3220
# text = Document 003003419 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003419	003003419	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3221
# text = A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	Cbl	Cbl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	b	b	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	zap	zap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	70	70	NUM	CD	NumType=Card	_	_	_	_
17	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
20	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3222
# text = Engagement of the T-cell receptor (TCR)-CD3 complex induces a rapid increase in the activities of Src-family and Syk/Zap-70-family kinases [1] [2].
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
16	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Src-	src-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Syk/Zap-70-family	Syk/Zap-70-family	NOUN	NN	Number=Sing	_	_	_	_
25	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
26	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	]	]	PUNCT	-RRB-	_	_	_	_	_
29	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3223
# text = These activated kinases then induce the tyrosine phosphorylation of multiple intracellular proteins, eventually leading to T-cell activation.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	induce	induce	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	eventually	eventually	ADV	RB	_	_	_	_	_
15	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3224
# text = One of the prominent substrates for these kinases is the adaptor protein Cbl [3] and recent studies suggest that Cbl negatively regulates upstream kinases such as Syk and Zap-70 [4] [5].
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
5	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	_
14	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	3	3	X	LS	_	_	_	_	SpaceAfter=No
16	]	]	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
19	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
20	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	_
23	negatively	negatively	ADV	RB	_	_	_	_	_
24	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
26	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Zap	Zap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	70	70	NUM	CD	NumType=Card	_	_	_	_
34	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	]	]	PUNCT	-RRB-	_	_	_	_	_
37	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3225
# text = Cbl-b, a homologue of Cbl, is widely expressed in many tissues and cells including hematopoietic cells [6] [7].
1	Cbl	Cbl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	widely	widely	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
15	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
19	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	]	]	PUNCT	-RRB-	_	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3226
# text = Cbl-b undergoes rapid tyrosine phosphorylation upon stimulation of the TCR and cytokine receptors [8] [9].
1	Cbl	Cbl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	b	b	NOUN	NN	Number=Sing	_	_	_	_
4	undergoes	undergo	NOUN	NNS	Number=Plur	_	_	_	_
5	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	upon	upon	ADP	IN	_	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3227
# text = The role of Cbl-b is unclear, however.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	b	b	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3228
# text = Here, we show that overexpression of Cbl-b in T cells induced the constitutive activation of the transcription factor nuclear factor of activated T cells (NFAT).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	b	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3229
# text = A loss-of-function mutation in Cbl-b disrupted the interaction between Cbl-b and Zap-70 and nearly completely abrogated the Cbl-b-mediated activation of NFAT.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	b	benefit	NOUN	NN	Number=Sing	_	_	_	_
12	disrupted	disrupt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	b	b	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Zap	Zap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	70	70	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	nearly	nearly	ADV	RB	_	_	_	_	_
25	completely	completely	ADV	RB	_	_	_	_	_
26	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	b-	b-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3230
# text = Unlike the proposed role of Cbl as a negative regulator, our results suggest that the Cbl homologue Cbl-b has a positive role in T-cell signaling, most likely via a direct interaction with the upstream kinase Zap-70.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
13	results	result	NOUN	NNS	Number=Plur	_	_	_	_
14	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	_
18	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
19	Cbl	Cbl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	b	b	NOUN	NN	Number=Sing	_	_	_	_
22	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	most	most	ADV	RBS	_	_	_	_	_
32	likely	likely	ADV	RB	_	_	_	_	_
33	via	via	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
36	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	Zap	Zap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3231
# text = Document 003003421 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003421	003003421	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3232
# text = Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	_
6	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
9	illegitimate	illegitimate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	"	"	PUNCT	''	_	_	_	_	_
11	V	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	J	j	NOUN	NN	Number=Sing	_	_	_	_
18	recombinase	recombinase	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3233
# text = A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
3	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	HSB	Hsb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	elucidates	elucidate	NOUN	NNS	Number=Plur	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	provocative	provocative	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
23	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3234
# text = The fusion cDNA results from an interstitial deletion between a previously unknown locus, SIL (SCL interrupting locus), and the 5' untranslated region of SCL.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
3	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	interstitial	interstitial	ADJ	JJ	Degree=Pos	_	_	_	_
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	SIL	SIL	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
18	interrupting	interrupt	VERB	VBG	VerbForm=Ger	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	'	's	PUNCT	``	_	_	_	_	_
26	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3235
# text = Similar to 1;14 translocations, this deletion disrupts the SCL 5' regulatory region.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	1;	1;	PUNCT	,	_	_	_	_	SpaceAfter=No
4	14	14	NUM	CD	NumType=Card	_	_	_	_
5	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	disrupts	disrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3236
# text = This event is probably mediated by V-(D)-J recombinase activity, although neither locus is an immunoglobulin or a T cell receptor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	event	event	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	probably	probably	ADV	RB	_	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	V	V	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	J	j	NOUN	NN	Number=Sing	_	_	_	_
14	recombinase	recombinase	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	although	although	SCONJ	IN	_	_	_	_	_
18	neither	neither	DET	DT	_	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3237
# text = Two other T cell lines, CEM and RPMI 8402, have essentially identical deletions.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	RPMI	RPMI	PROPN	NNP	Number=Sing	_	_	_	_
10	8402	8402	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	essentially	essentially	ADV	RB	_	_	_	_	_
14	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
15	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3238
# text = Thus, in lymphocytes, growth-affecting genes other than immune receptors risk rearrangements.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	affecting	affecting	VERB	VBG	VerbForm=Ger	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	risk	risk	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3239
# text = Document 003003423 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003423	003003423	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3240
# text = Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	10	10	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3241
# text = IL-4 and IL-10 inhibit the cytokine production and mRNA expression by monocytes/macrophages.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3242
# text = To investigate the molecular mechanism of the inhibitory effect on transcriptional or post-transcriptional regulation of IL-6 gene expression by IL-4 and IL-10, we studied IL-6 production, expression level of IL-6 mRNA, IL-6 promoter activity, transcriptional activity of NF-kappaB and NF-IL-6, and IL-6 mRNA stability in human monocytic cell lines, THP-1 and U937, stimulated by PMA and LPS in the absence or the presence of IL-4 or IL-10.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	post	post	X	AFX	_	_	_	_	SpaceAfter=No
14	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	level	level	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	6	6	NUM	CD	NumType=Card	_	_	_	_
44	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	6	6	NUM	CD	NumType=Card	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
50	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
53	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	6	6	NUM	CD	NumType=Card	_	_	_	_
69	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
70	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
71	in	in	ADP	IN	_	_	_	_	_
72	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
73	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
74	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
75	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
76	,	,	PUNCT	,	_	_	_	_	_
77	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
79	1	1	NUM	CD	NumType=Card	_	_	_	_
80	and	and	CCONJ	CC	_	_	_	_	_
81	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
84	by	by	ADP	IN	_	_	_	_	_
85	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
86	and	and	CCONJ	CC	_	_	_	_	_
87	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
88	in	in	ADP	IN	_	_	_	_	_
89	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
90	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
91	or	or	CCONJ	CC	_	_	_	_	_
92	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
93	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
94	of	of	ADP	IN	_	_	_	_	_
95	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
96	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
97	4	4	NUM	CD	NumType=Card	_	_	_	_
98	or	or	CCONJ	CC	_	_	_	_	_
99	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
100	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
101	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
102	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3243
# text = Both IL-4 and IL-10 were seen to inhibit IL-6 production and the expression of IL-6 mRNA in both monocytic cell lines studied.
1	Both	both	DET	DT	_	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	_
27	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
30	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3244
# text = In chloramphenicol acetyltransferase assays, utilizing the transient transfection of a chloramphenicol acetyltransferase reporter plasmid containing the IL-6 gene promoter, IL-4, but not IL-10, suppressed the transcriptional activity of the IL-6 gene promoter stimulated by PMA and LPS.
1	In	in	ADP	IN	_	_	_	_	_
2	chloramphenicol	chloramphenicol	ADJ	JJ	Degree=Pos	_	_	_	_
3	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	utilizing	utilize	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
13	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	IL	Il	SYM	$	_	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	6	6	NUM	CD	NumType=Card	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
45	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3245
# text = Electrophoretic mobility shift assays showed that IL-4, but not IL-10, inhibited nuclear NF-kappaB activity, and that IL-4 and IL-10 did not affect NF-IL-6 activity.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	IL	Il	SYM	$	_	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	4	4	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	10	10	NUM	CD	NumType=Card	_	_	_	_
33	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	6	6	NUM	CD	NumType=Card	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3246
# text = On the other hand, IL-10 enhanced the degradation of IL-6 mRNA in a mRNA stability assay.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
20	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
21	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3247
# text = These results suggest that IL-4 may inhibit the transcription of the IL-6 gene by affecting NF-kappaB binding activity, while IL-10 may inhibit the IL-6 mRNA levels post-transcriptionally, without suppressing promoter activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	while	while	SCONJ	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	post-transcriptionally	post-transcriptionally	ADV	RB	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	without	without	SCONJ	IN	_	_	_	_	_
41	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
42	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
43	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3248
# text = Therefore, we conclude that IL-4 and IL-10 inhibit IL-6 production by different mechanisms in human monocytic cell lines.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3249
# text = Document 003003424 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003424	003003424	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3250
# text = Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior.
1	Flutamide	Flutamide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	hirsutism	hirsutism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	term	term	NOUN	NN	Number=Sing	_	_	_	_
11	clinical	clinical	NOUN	NN	Number=Sing	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	endocrine	endocrine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
15	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3251
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3252
# text = To investigate the long-term effects of treatment with low doses of flutamide on clinical and hormonal parameters, as well as on the androgen receptor status, in hirsute women.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	term	term	NOUN	NN	Number=Sing	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	flutamide	flutamide	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
19	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	hirsute	hirsute	ADJ	JJ	Degree=Pos	_	_	_	_
32	women	woman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3253
# text = DESIGN:
1	DESIGN	Design	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3254
# text = Eighteen hirsute patients with regular menses were studied basally and during treatment with 125 mg flutamide, three times per day for 12 months.
1	Eighteen	eighteen	NUM	CD	NumType=Card	_	_	_	_
2	hirsute	hirsute	ADJ	JJ	Degree=Pos	_	_	_	_
3	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	regular	regular	ADJ	JJ	Degree=Pos	_	_	_	_
6	menses	mense	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	basally	basally	ADV	RB	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	125	125	NUM	CD	NumType=Card	_	_	_	_
15	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
16	flutamide	flutamide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	three	three	NUM	CD	NumType=Card	_	_	_	_
19	times	time	NOUN	NNS	Number=Plur	_	_	_	_
20	per	per	ADP	IN	_	_	_	_	_
21	day	day	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	_
24	months	month	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3255
# text = Barrier or intrauterine contraception was used during the study in sexually active women.
1	Barrier	barrier	NOUN	NN	Number=Sing	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	intrauterine	intrauterine	NOUN	NN	Number=Sing	_	_	_	_
4	contraception	contraception	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	study	study	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	sexually	sexually	ADV	RB	_	_	_	_	_
12	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
13	women	woman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3256
# text = Safety parameters were assessed throughout the study.
1	Safety	Safety	PROPN	NNP	Number=Sing	_	_	_	_
2	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	throughout	throughout	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3257
# text = Hirsutism, graded by the modified Ferriman-Gallwey score, and hormonal parameters were evaluated basally and at 4-month intervals during treatment.
1	Hirsutism	Hirsutism	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	graded	grad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Ferriman	Ferriman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Gallwey	Gallwey	PROPN	NNP	Number=Sing	_	_	_	_
10	score	score	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
14	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	basally	basally	ADV	RB	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	month	month	NOUN	NN	Number=Sing	_	_	_	_
23	intervals	interval	NOUN	NNS	Number=Plur	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3258
# text = Gonadotropin-releasing hormone and ACTH stimulation tests were performed before and after 3 to 4 months of therapy.
1	Gonadotropin	Gonadotropin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	releasing	release	VERB	VBG	VerbForm=Ger	_	_	_	_
4	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	ACTH	Acth	DET	DT	_	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	tests	test	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	before	before	ADV	RB	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	months	month	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3259
# text = In addition, the concentration of androgen receptors in mononuclear leukocytes was measured, in both the follicular and luteal phases of the menstrual cycle, basally and after 4 months of flutamide treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	luteal	luteal	ADJ	JJ	Degree=Pos	_	_	_	_
21	phases	phase	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	menstrual	menstrual	ADJ	JJ	Degree=Pos	_	_	_	_
25	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	basally	basally	ADV	RB	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	4	4	NUM	CD	NumType=Card	_	_	_	_
31	months	month	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	flutamide	flutamide	ADJ	JJ	Degree=Pos	_	_	_	_
34	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3260
# text = RESULTS:
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3261
# text = Flutamide was well tolerated in all women, with the noticeable exception of one patient who presented increased serum transaminase after 8 months of therapy.
1	Flutamide	Flutamide	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	tolerated	tolerate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	women	woman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	noticeable	noticeable	ADJ	JJ	Degree=Pos	_	_	_	_
12	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	who	who	PRON	WP	PronType=Rel	_	_	_	_
17	presented	present	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
20	transaminase	transaminase	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	8	8	NUM	CD	NumType=Card	_	_	_	_
23	months	month	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3262
# text = Hirsutism markedly improved in all women during the treatment (Ferriman-Gallwey score after 1 year: 4.1 +/- 0.5 versus 14.1 +/- 0.9).
1	Hirsutism	Hirsutism	INTJ	UH	_	_	_	_	_
2	markedly	markedly	ADV	RB	_	_	_	_	_
3	improved	improve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	all	all	DET	DT	_	_	_	_	_
6	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Ferriman	Ferriman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Gallwey	Gallwey	PROPN	NNP	Number=Sing	_	_	_	_
14	score	score	NOUN	NN	Number=Sing	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	year	year	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	4.1	4.1	NUM	CD	NumType=Card	_	_	_	_
20	+/-	+/-	SYM	SYM	_	_	_	_	_
21	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
22	versus	versus	ADP	IN	_	_	_	_	_
23	14.1	14.1	NUM	CD	NumType=Card	_	_	_	_
24	+/-	+/-	SYM	SYM	_	_	_	_	_
25	0.9	0.9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3263
# text = A reduction of serum androgens was found, whereas no change was observed in either basal or GnRH-stimulated gonadotropins or in the cortisol and 17 alpha-hydroxyprogesterone response to ACTH.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
5	androgens	androgen	NOUN	NNS	Number=Plur	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	whereas	whereas	SCONJ	IN	_	_	_	_	_
10	no	no	DET	DT	_	_	_	_	_
11	change	change	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	either	either	DET	DT	_	_	_	_	_
16	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	GnRH	GnRh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	gonadotropins	gonadotropin	NOUN	NNS	Number=Plur	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	17	17	NUM	CD	NumType=Card	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	hydroxyprogesterone	hydroxyprogesterone	NOUN	NN	Number=Sing	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	ACTH	ACTH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3264
# text = Cycles remained ovulatory.
1	Cycles	cycle	NOUN	NNS	Number=Plur	_	_	_	_
2	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	ovulatory	ovulatory	ADV	RB	_	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3265
# text = Before treatment, the number of androgen receptors was higher in the luteal than in the follicular phase.
1	Before	before	ADP	IN	_	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	number	number	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	luteal	luteal	NOUN	NN	Number=Sing	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
18	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3266
# text = This rhythmic differentiation disappeared after the patients had been given the antiandrogen drug.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	rhythmic	rhythmic	ADJ	JJ	Degree=Pos	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	disappeared	disappear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
8	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	given	give	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	antiandrogen	antiandrogen	ADJ	JJ	Degree=Pos	_	_	_	_
13	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3267
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3268
# text = Flutamide is effective in the treatment of hirsutism but requires constant surveillance of liver function.
1	Flutamide	Flutamide	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	hirsutism	hirsutism	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
12	surveillance	surveillance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3269
# text = Androgen receptor blockade might be potentiated by a reduction of serum androgens.
1	Androgen	Androgen	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
4	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	androgens	androgen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3270
# text = Flutamide affects androgen receptor behavior during the menstrual cycle.
1	Flutamide	Flutamide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	affects	affect	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
3	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	menstrual	menstrual	ADJ	JJ	Degree=Pos	_	_	_	_
9	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3271
# text = The meaning of this finding remains to be elucidated .
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	meaning	meaning	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
6	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3272
# text = Document 003003430 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003430	003003430	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3273
# text = E1A gene expression induces susceptibility to killing by NK cells following immortalization but not adenovirus infection of human cells.
1	E1A	E1a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	SCONJ	IN	_	_	_	_	_
7	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
12	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	adenovirus	adenovirus	ADJ	JJ	Degree=Pos	_	_	_	_
16	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3274
# text = Adenovirus
1	Adenovirus	Adenovirus	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3275
# text = (Ad) infection and E1A transfection were used to model changes in susceptibility to NK cell killing caused by transient vs stable E1A expression in human cells.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ad	ad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	E1A	E1a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	_
12	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	killing	kill	NOUN	NN	Number=Sing	_	_	_	_
19	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
22	vs	versus	ADP	IN	Abbr=Yes	_	_	_	_
23	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
24	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3276
# text = Only stably transfected target cells exhibited cytolytic susceptibility, despite expression of equivalent levels of E1A proteins in Ad-infected targets.
1	Only	only	ADV	RB	_	_	_	_	_
2	stably	stably	ADV	RB	_	_	_	_	_
3	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	target	target	NOUN	NN	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	exhibited	exhibite	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	despite	despite	ADP	IN	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	E1A	E1a	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Ad	ad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3277
# text = The inability of E1A gene products to induce cytolytic susceptibility during infection was not explained by an inhibitory effect of viral infection on otherwise susceptible target cells or by viral gene effects on class I MHC antigen expression on target cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	E1	E1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	otherwise	otherwise	ADV	RB	_	_	_	_	_
26	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
27	target	target	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	class	class	NOUN	NN	Number=Sing	_	_	_	_
36	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
37	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
38	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	target	target	NOUN	NN	Number=Sing	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3278
# text = This differential effect of E1A expression on the cytolytic phenotypes of infected and stably transfected human cells suggests that human NK cells provide an effective immunologic barrier against the in vivo survival and neoplastic progression of E1A-immortalized cells that may emerge from the reservoir of persistently infected cells in the human host.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	E1	E1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	stably	stably	ADV	RB	_	_	_	_	_
16	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
27	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
28	barrier	barrier	NOUN	NN	Number=Sing	_	_	_	_
29	against	against	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
33	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
36	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	that	that	PRON	WDT	PronType=Rel	_	_	_	_
43	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
44	emerge	emerge	VERB	VB	VerbForm=Inf	_	_	_	_
45	from	from	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	persistently	persistently	ADV	RB	_	_	_	_	_
50	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
55	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3279
# text = Document 003003434 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003434	003003434	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3280
# text = Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
12	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
16	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3281
# text = We have investigated the effect of redox changes in vivo on the differentiation of two human myeloid cell lines, HL-60 and KG-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	60	60	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	KG	kg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3282
# text = The glutathione-depleting agent diethyl maleate (DEM) prevented the development of differentiated features in response to phorbol esters, including adherence of the cells to plastic surfaces and repression of the myeloperoxidase and CD34 genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	depleting	deplet	NOUN	NN	Number=Sing	_	_	_	_
5	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
6	diethyl	diethyl	NOUN	NN	Number=Sing	_	_	_	_
7	maleate	maleate	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	DEM	DEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
21	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
30	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	myeloperoxidase	myeloperoxidase	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	CD34	Cd34	NOUN	NN	Number=Sing	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3283
# text = Moreover, DEM abolished phorbol 12-myristate 13-acetate-induced activation of the transcription factors AP-1 and Egr-1, suggesting that inhibition of differentiation may be due, at least in part, to redox modifications of these proteins.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DEM	DEM	PROPN	NNP	Number=Sing	_	_	_	_
4	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
6	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	due	due	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	at	at	ADV	RB	_	_	_	_	_
36	least	least	ADV	RBS	Degree=Sup	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	redox	redox	VERB	VB	VerbForm=Inf	_	_	_	_
42	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
45	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3284
# text = Document 003003436 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003436	003003436	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3285
# text = A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
3	member	member	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	leucine	leucine	NOUN	NN	Number=Sing	_	_	_	_
7	zipper	zipper	NOUN	NN	Number=Sing	_	_	_	_
8	class	class	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
16	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	ADP	IN	_	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3286
# text = Several mutants derived from transformed human B cell lines are defective in expressing major histocompatibility complex (MHC) class II genes.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
3	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3287
# text = The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box, a conserved transcriptional element in the promoter region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	at	at	ADV	RB	_	_	_	_	_
11	least	least	ADV	RBS	Degree=Sup	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	_
24	X	x	NOUN	NN	Number=Sing	_	_	_	_
25	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3288
# text = A complementary DNA encoding a DNA-binding protein (human X box binding protein, hXBP-1) whose target is the human DR alpha X box and the 3' flanking region has now been cloned.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	X	x	NOUN	NN	Number=Sing	_	_	_	_
13	box	box	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	hXBP	hXBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
22	target	target	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	DR	Dr	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	X	x	SYM	SYM	_	_	_	_	_
29	box	box	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	'	'	PUNCT	``	_	_	_	_	_
34	flanking	flank	NOUN	NN	Number=Sing	_	_	_	_
35	region	region	NOUN	NN	Number=Sing	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	now	now	ADV	RB	_	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3289
# text = This complementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product, and its target sequence was closely related to the palindromic target sequence of c-jun.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	encoded	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
9	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
16	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
20	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	target	target	NOUN	NN	Number=Sing	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	closely	closely	ADV	RB	_	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
29	target	target	NOUN	NN	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3290
# text = Mutation of the hXBP-1 DNA target sequence decreased DR alpha promoter activity in vivo.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hXBP	hxbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	target	target	NOUN	NN	Number=Sing	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3291
# text = These studies suggest that the hXBP-1 protein acts as a transcription factor in B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hXBP	hxbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3292
# text = Document 003003437 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003437	003003437	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3293
# text = Binding characteristics of the glucocorticoid receptor in peripheral blood lymphocytes in multiple sclerosis.
1	Binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
2	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	sclerosis	sclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3294
# text = Although the exact etiology of multiple sclerosis (MS) remains unresolved, immune reactions are believed to be the central pathogenic mechanisms.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
4	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
7	sclerosis	sclerosis	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	MS	MS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unresolved	unresolved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
22	pathogenic	pathogenic	NOUN	NN	Number=Sing	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3295
# text = Endogenous and therapeutic steroid hormones affect the immune system, and inflammatory diseases are associated with activation of the hypothalamic-pituitary-adrenal axis, providing evidence of an immune-endocrine interplay.
1	Endogenous	Endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
4	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
6	affect	affect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
9	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
25	axis	axis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	providing	provid	VERB	VBG	VerbForm=Ger	_	_	_	_
28	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	immune	immune	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
34	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3296
# text = Function tests in MS have revealed dysregulation of the hypothalamic-pituitary-adrenal system in a substantial proportion of patients.
1	Function	function	NOUN	NN	Number=Sing	_	_	_	_
2	tests	test	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	MS	MS	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-pituitary-adrenal	-pituitary-adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
16	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3297
# text = We characterized glucocorticoid receptor (GR) binding in peripheral blood lymphocytes from 39 MS patients and 14 age- and sex-matched controls with respect to dissociation constant and binding capacity, using a whole-cell binding assay with [3H]dexamethasone as the ligand.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	39	39	NUM	CD	NumType=Card	_	_	_	_
15	MS	MS	PROPN	NNP	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	14	14	NUM	CD	NumType=Card	_	_	_	_
19	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	sex	sex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-matched	-matched	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
29	constant	constant	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
32	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	whole	whole	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
40	assay	assay	ADV	RB	_	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	3H	3H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
46	as	as	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3298
# text = GR binding parameters did not differ significantly between patients (Kd 8.98 +/- 1.07 nM, Bmax 183 +/- 29.8 fmol/mg) and controls (Kd 9.36 +/- 1.17 nM, Bmax 158 +/- 16 fmol/mg).
1	GR	Gr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
7	significantly	significantly	ADV	RB	_	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Kd	K	PROPN	NNP	Number=Sing	_	_	_	_
12	8.98	8.98	NUM	CD	NumType=Card	_	_	_	_
13	+/-	+/-	SYM	SYM	_	_	_	_	_
14	1.07	1.07	NUM	CD	NumType=Card	_	_	_	_
15	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Bmax	Bmax	PROPN	NNP	Number=Sing	_	_	_	_
18	183	183	NUM	CD	NumType=Card	_	_	_	_
19	+/-	+/-	SYM	SYM	_	_	_	_	_
20	29.8	29.8	NUM	CD	NumType=Card	_	_	_	_
21	fmol	fmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	controls	controls	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Kd	K	PROPN	NNP	Number=Sing	_	_	_	_
29	9.36	9.36	NUM	CD	NumType=Card	_	_	_	_
30	+/-	+/-	SYM	SYM	_	_	_	_	_
31	1.17	1.17	NUM	CD	NumType=Card	_	_	_	_
32	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	Bmax	Bmax	PROPN	NNP	Number=Sing	_	_	_	_
35	158	158	NUM	CD	NumType=Card	_	_	_	_
36	+/-	+/-	SYM	SYM	_	_	_	_	_
37	16	16	NUM	CD	NumType=Card	_	_	_	_
38	fmol	fmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
40	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3299
# text = No effect of age, sex, course, duration or severity of disease, or prior steroid treatments was detected.
1	No	no	DET	DT	_	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	sex	sex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	course	course	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	severity	severity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
18	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	treatments	treatment	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3300
# text = GR binding parameters were analyzed in relation to the results of the combined dexamethasone-CRH test, which reflects corticosteroid receptor function at the hypothalamus, in 30 patients and 9 controls.
1	GR	Gr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CRH	CRh	NOUN	NN	Number=Sing	_	_	_	_
17	test	test	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	corticosteroid	corticosteroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	function	function	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	hypothalamus	hypothalamus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	30	30	NUM	CD	NumType=Card	_	_	_	_
30	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	9	9	NUM	CD	NumType=Card	_	_	_	_
33	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3301
# text = While controls showed a moderate correlation between binding affinity of the GR in lymphocytes and regulatory function at the hypothalamic level, the patients did not.
1	While	while	SCONJ	IN	_	_	_	_	_
2	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
25	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3302
# text = These data suggest that the physiological relationship between binding and function of the glucocorticoid receptor is disturbed in MS.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
7	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	disturbed	distur	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	MS	MS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3303
# text = Document 003003438 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003438	003003438	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3304
# text = Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kappa B transcription factors.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
5	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cross-talk	cross-talk	NOUN	NN	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3305
# text = Despite the widespread use of glucocorticoids in the treatment of diseases characterized by inflammation, the molecular mechanism(s) by which these hormones exert this beneficial effect in patients with asthma remains to be elucidated.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
4	use	use	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
12	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	s	s	X	AFX	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
26	exert	exert	ADP	IN	Typo=Yes	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
34	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3306
# text = Therefore, we have studied the transcriptional regulation of intercellular adhesion molecule-1 (ICAM-1) as adhesion molecules are likely to play a causal role in inflammation in promoting cell-cell and cell-matrix interactions.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
22	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	causal	causal	ADJ	JJ	Degree=Pos	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	SCONJ	IN	_	_	_	_	_
33	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
41	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3307
# text = We observed that in a monocytic (U937) and a bronchial epithelial (H292) cell-line dexamethasone strongly suppressed basal and induced ICAM-1 expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	monocytic	monocytic	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
13	epithelial	epithelial	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	H292	H292	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
21	strongly	strongly	ADV	RB	_	_	_	_	_
22	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3308
# text = Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).
1	Subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	O	of	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	tumour	tumour	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
27	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	upregulate	upregulate	ADJ	JJ	Degree=Pos	_	_	_	_
37	ICAM	ICAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
52	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	target	target	NOUN	NN	Number=Sing	_	_	_	_
55	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	TGGAAATTCC	TGGAAATTCC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3309
# text = No glucocorticoid recognition sequences are present in this promoter region and dexamethasone is still able to repress transcription when the multimerized NF-kappa B sequence is transactivated by TNF-alpha upon transfection in 293 cells.
1	No	no	DET	DT	_	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	still	still	ADV	RB	_	_	_	_	_
15	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	alpha	alpha	ADV	RB	_	_	_	_	_
33	upon	upon	ADP	IN	_	_	_	_	_
34	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	293	293	NUM	CD	NumType=Card	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3310
# text = We propose that direct interaction between the glucocorticoid receptor and nuclear factor-kappa B factors is at least a partial explanation for the effects of this hormone in inflammatory diseases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
22	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3311
# text = Document 003003442 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003442	003003442	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3312
# text = Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	transactivates	transactivate	NOUN	NNS	Number=Plur	_	_	_	_
9	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3313
# text = Several lines of evidence are compatible with the hypothesis that Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) or leader protein (EBNA-LP) affects expression of the EBV latent infection membrane protein LMP1.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	EBNA	EBNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	X	LS	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	LP	LP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
39	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
40	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
41	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3314
# text = We now demonstrate the following.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3315
# text = (i) Acute transfection and expression of EBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased LMP1 expression in P3HR-1-infected Burkitt's lymphoma cells and the P3HR-1 or Daudi cell line.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	i	i	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Acute	Acute	ADJ	JJ	Degree=Pos	_	_	_	_
5	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	under	under	ADP	IN	_	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	40	40	NUM	CD	NumType=Card	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	Moloney	Moloney	NOUN	NN	Number=Sing	_	_	_	_
20	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
23	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
24	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	P3HR	P3HR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	's	's	PART	POS	_	_	_	_	_
36	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	P3HR	P3hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3316
# text = (ii) Transfection and expression of EBNA-LP alone had no effect on LMP1 expression and did not act synergistically with EBNA-2 to affect LMP1 expression.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	LP	LP	PROPN	NNP	Number=Sing	_	_	_	_
11	alone	alone	ADV	RB	_	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
22	synergistically	synergistically	ADV	RB	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
29	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3317
# text = (iii) LMP1 expression in Daudi and P3HR-1-infected cells was controlled at the mRNA level, and EBNA-2 expression in Daudi cells increased LMP1 mRNA.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	P3HR	P3hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-infected	-infected	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
31	mRNA.	mRNA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3318
# text = (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB, Louckes, and BL30.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
3	v	have	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	No	no	DET	DT	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	EBV	Ebv	PROPN	NNP	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
18	since	since	ADP	IN	_	_	_	_	_
19	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
22	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
29	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
32	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
45	BJAB	BJAB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	Louckes	Louckes	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	BL30	BL30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3319
# text = (v) An EBNA-2-responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	512	512	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	+40	+40	NUM	CD	NumType=Card	_	_	_	_
19	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	since	since	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
28	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3320
# text = (vi) The EBV type 2 EBNA-2 transactivated LMP1 as well as the EBV type 1 EBNA-2.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	vi	vi	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3321
# text = (vii) Two deletions within the EBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1, whereas a transformation-competent EBNA-2 deletion mutant did transactivate LMP1.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	vii	vii	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Two	two	NUM	CD	NumType=Card	_	_	_	_
5	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
15	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
16	incompetent	incompetent	NOUN	NN	Number=Sing	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
20	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	whereas	SCONJ	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	competent	competent	NOUN	NN	Number=Sing	_	_	_	_
27	EBNA	EBNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
31	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
32	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
34	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3322
# text = LMP1 is a potent effector of B-lymphocyte activation and can act synergistically with EBNA-2 to induce cellular CD23 gene expression.
1	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
5	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
14	synergistically	synergistically	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
22	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3323
# text = Thus, EBNA-2 transactivation of LMP1 amplifies the biological impact of EBNA-2 and underscores its central role in EBV-induced growth transformation.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
9	amplifies	amplify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
12	impact	impact	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	underscores	underscore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3324
# text = Document 003003446 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003446	003003446	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3325
# text = Microtubules mediate cellular 25-hydroxyvitamin D3 trafficking and the genomic response to 1,25-dihydroxyvitamin D3 in normal human monocytes.
1	Microtubules	Microtubule	NOUN	NNS	Number=Plur	_	_	_	_
2	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
4	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	hydroxyvitamin	hydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
7	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
8	trafficking	trafficking	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
17	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3326
# text = The genomic actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the intracellular vitamin D receptor (VDR).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
3	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
8	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
22	D	d	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3327
# text = Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the sterol-VDR complex, the role of microtubules in the response to 1,25(OH)2D3 has not been studied in viable cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	immunocytochemistry	immunocytochemistry	PROPN	NNP	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	microtubular	microtubular	ADJ	JJ	Degree=Pos	_	_	_	_
9	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
10	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	access	access	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	sterol	sterol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	microtubules	microtubule	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
33	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	viable	viable	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3328
# text = Our studies examined this interaction in normal human monocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3329
# text = Monocytes convert 25(OH)D3 to 1,25(OH)2D3 and to 24-hydroxylated metabolites more polar than 1,25(OH)2D3.
1	Monocytes	Monocytes	PROPN	NNP	Number=Sing	_	_	_	_
2	convert	convert	NOUN	NN	Number=Sing	_	_	_	_
3	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	D3	D3	NUM	CD	NumType=Card	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hydroxylated	hydroxylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	polar	polar	ADJ	JJ	Degree=Pos	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3330
# text = Microtubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce 24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3-VDR binding.
1	Microtubule	Microtubule	NOUN	NN	Number=Sing	_	_	_	_
2	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
3	totally	totally	ADV	RB	_	_	_	_	_
4	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
9	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
25	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	without	without	SCONJ	IN	_	_	_	_	_
30	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
31	either	either	DET	DT	_	_	_	_	_
32	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
33	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
38	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
41	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
48	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3331
# text = Thus, intact microtubules are essential for 1,25(OH)2D3-dependent modulation of gene transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
4	microtubules	microtubule	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3332
# text = Interestingly, microtubule disruption also decreased monocyte 1,25(OH)2D3 synthesis, not by decreasing the Vmax of monocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	microtubule	microtubule	ADJ	JJ	Degree=Pos	_	_	_	_
4	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
13	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	decreasing	decrease	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Vmax	Vmax	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
22	mitochondrial	mitochondrial	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Km	Km	PROPN	NNP	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3333
# text = We examined 25(OH)D3 transport.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	D3	D3	NUM	CD	NumType=Card	_	_	_	_
8	transport	transport	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3334
# text = Microtubule disruption did not affect total cellular 25(OH)D3 uptake but reduced its intracellular trafficking to the mitochondria.
1	Microtubule	Microtubule	NOUN	NN	Number=Sing	_	_	_	_
2	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
6	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
7	cellular	celular	NOUN	NN	Number=Sing	_	_	_	_
8	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
13	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
18	trafficking	traffick	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mitochondria	mitochondria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3335
# text = Thus, microtubules participate in intracellular 25(OH)D3 transport, and their integrity determines normal 1,25(OH)2D3 synthesis.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	microtubules	microtubule	NOUN	NNS	Number=Plur	_	_	_	_
4	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	D3	D3	NUM	CD	NumType=Card	_	_	_	_
12	transport	transport	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	integrity	integrity	NOUN	NN	Number=Sing	_	_	_	_
17	determines	determine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
24	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3336
# text = Document 003003447 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003447	003003447	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3337
# text = Regulation of interferon-gamma gene expression.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3338
# text = Interferon-gamma ( IFN-gamma ), also known as type II interferon, is an important immunoregulatory gene that has multiple effects on the development, maturation, and function of the immune system.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
15	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
25	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	function	function	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
37	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3339
# text = IFN-gamma mRNA and protein are expressed predominantly by T cells and large granular lymphocytes.
1	IFN-	IFN-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	predominantly	predominantly	ADV	RB	_	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
14	granular	granular	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3340
# text = The IFN-gamma mRNA is induced/inhibited in these cell types by a wide variety of extracellular signals, thus implicating a number of diverse, yet convergent signal transduction pathways in its transcriptional control.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	types	type	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
17	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	thus	thus	ADV	RB	_	_	_	_	_
23	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	number	number	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	yet	yet	CCONJ	CC	_	_	_	_	_
30	convergent	convergent	ADJ	JJ	Degree=Pos	_	_	_	_
31	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
32	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
33	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3341
# text = In this review, I describe how DNA methylation and specific DNA binding proteins may regulate transcription of the IFN-gamma gene in response to extracellular signals.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	how	how	ADV	WRB	PronType=Int	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3342
# text = Document 003003449 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003449	003003449	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3343
# text = Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	death	death	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3344
# text = Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain."
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TNFR	Tnfr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	also	also	ADV	RB	_	_	_	_	_
16	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	APO	APO	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	engage	engage	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
31	through	through	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	homology	homology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	designated	designate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
41	death	death	NOUN	NN	Number=Sing	_	_	_	_
42	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpaceAfter=No
44	"	"	PUNCT	''	_	_	_	_	_

# sent_id = 3345
# text = Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB.
1	Another	another	DET	DT	_	_	_	_	_
2	death	death	NOUN	NN	Number=Sing	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	member	member	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	death	death	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
26	both	both	CCONJ	CC	_	_	_	_	_
27	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3346
# text = Expression of DR3 appears to be restricted to tissues enriched in lymphocytes.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
10	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3347
# text = DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE.
1	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
11	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	FADD	fadd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	FLICE	FLICE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3348
# text = Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DR3	DR3	NUM	CD	NumType=Card	_	_	_	_
4	likely	likely	ADV	RB	_	_	_	_	_
5	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
11	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3349
# text = Document 003003452 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003452	003003452	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3350
# text = In vivo modulation of glucocorticoid receptor mRNA by inhaled fluticasone propionate in bronchial mucosa and blood lymphocytes in subjects with mild asthma.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	inhaled	inhal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	fluticasone	fluticasone	NOUN	NN	Number=Sing	_	_	_	_
11	propionate	propionate	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
14	mucosa	mucosa	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	mild	mild	ADJ	JJ	Degree=Pos	_	_	_	_
22	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3351
# text = BACKGROUND: In vivo regulation of the glucocorticoid receptor (GR) by glucocorticoids provides a means of modulating sensitivity of targeted cells.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
15	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	means	means	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	SCONJ	IN	_	_	_	_	_
19	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3352
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3353
# text = We sought to determine the in vivo modulation of GR mRNA expression by fluticasone propionate (FP) in subjects with mild asthma.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
8	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	fluticasone	fluticasone	ADJ	JJ	Degree=Pos	_	_	_	_
15	propionate	propionate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	FP	Fp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	mild	mild	ADJ	JJ	Degree=Pos	_	_	_	_
23	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3354
# text = METHODS: Ten atopic asthmatic subjects were treated with FP 250 microg twice daily for 4 weeks.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Ten	ten	NUM	CD	NumType=Card	_	_	_	_
4	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
5	asthmatic	asthmatic	ADJ	JJ	Degree=Pos	_	_	_	_
6	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	FP	Fp	NOUN	NN	Number=Sing	_	_	_	_
11	250	250	NUM	CD	NumType=Card	_	_	_	_
12	microg	microg	NOUN	NN	Number=Sing	_	_	_	_
13	twice	twice	ADV	RB	NumType=Mult	_	_	_	_
14	daily	daily	ADV	RB	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3355
# text = Before and after treatment, the patients underwent fiberoptic bronchoscopy with endobronchial biopsy and sampling of venous blood for measurements of GR mRNA levels.
1	Before	before	ADP	IN	_	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	after	after	ADP	IN	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
9	fiberoptic	fiberoptic	ADJ	JJ	Degree=Pos	_	_	_	_
10	bronchoscopy	bronchoscopy	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	endobronchial	endobronchial	ADJ	JJ	Degree=Pos	_	_	_	_
13	biopsy	biopsy	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	sampling	sampling	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	venous	venous	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	measurements	measurement	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
23	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3356
# text = A solution hybridization assay was used for quantitative analysis of GR mRNA.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	solution	solution	NOUN	NN	Number=Sing	_	_	_	_
3	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
9	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3357
# text = In addition, a 24-hour urinary cortisol excretion and an adrenocorticotropic hormone test before and after treatment with FP were performed.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
8	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
9	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
10	excretion	excretion	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	adrenocorticotropic	adrenocorticotropic	ADJ	JJ	Degree=Pos	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
15	test	test	NOUN	NN	Number=Sing	_	_	_	_
16	before	before	ADP	IN	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	FP	FP	PROPN	NNP	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3358
# text = RESULTS: A high interindividual variation in GR mRNA expression was seen.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	interindividual	interindividual	ADJ	JJ	Degree=Pos	_	_	_	_
6	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3359
# text = However, we detected a significant reduction of the GR mRNA levels in the endobronchial biopsy specimens after FP treatment (36.6 +/- 23.1 and 25.0 +/- 10.9 amol GR mRNA/microg RNA, respectively; P <.01).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	endobronchial	endobronchial	ADJ	JJ	Degree=Pos	_	_	_	_
16	biopsy	biopsy	NOUN	NN	Number=Sing	_	_	_	_
17	specimens	specimen	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	FP	Fp	NOUN	NN	Number=Sing	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	36.6	36.6	NUM	CD	NumType=Card	_	_	_	_
23	+/-	+/-	SYM	SYM	_	_	_	_	_
24	23.1	23.1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	25.0	25.0	NUM	CD	NumType=Card	_	_	_	_
27	+/-	+/-	SYM	SYM	_	_	_	_	_
28	10.9	10.9	NUM	CD	NumType=Card	_	_	_	_
29	amol	amol	NOUN	NN	Number=Sing	_	_	_	_
30	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
31	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	microg	microg	PROPN	NNP	Number=Sing	_	_	_	_
34	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	P	p	PROPN	NNP	Number=Sing	_	_	_	_
39	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	.01	.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3360
# text = In the peripheral blood lymphocytes an even more striking downregulation of the GR by its cognate ligand was documented (30.3 +/- 26.5 and 8.8 +/- 5 amol GR mRNA/microg RNA, respectively; P <.001), possibly reflecting differences in glucocorticoid sensitivity between tissues.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	even	even	ADV	RB	_	_	_	_	_
8	more	more	ADV	RBR	_	_	_	_	_
9	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
10	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	documented	document	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	30.3	30.3	NUM	CD	NumType=Card	_	_	_	_
22	+/-	+/-	SYM	SYM	_	_	_	_	_
23	26.5	26.5	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	8.8	8.8	NUM	CD	NumType=Card	_	_	_	_
26	+/-	+/-	SYM	SYM	_	_	_	_	_
27	5	5	NUM	CD	NumType=Card	_	_	_	_
28	amol	amol	NOUN	NN	Number=Sing	_	_	_	_
29	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
30	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	microg	microg	NOUN	NN	Number=Sing	_	_	_	_
33	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
36	;	;	PUNCT	,	_	_	_	_	_
37	P	P	PROPN	NNP	Number=Sing	_	_	_	_
38	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	possibly	possibly	ADV	RB	_	_	_	_	_
43	reflecting	reflect	VERB	VBG	VerbForm=Ger	_	_	_	_
44	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
47	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
48	between	between	ADP	IN	_	_	_	_	_
49	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3361
# text = A small but significant reduction of the 24-hour urinary cortisol excretion was observed (233 +/- 109 and 157 +/- 66 nmol/L, respectively; P <.01), whereas the feedback regulation of glucocorticoid synthesis by means of the hypothalamic-pituitary-adrenal axis as assessed by the adrenocorticotropic hormone test remained normal after treatment with FP.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	but	but	CCONJ	CC	_	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
11	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
12	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
13	excretion	excretion	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	233	233	NUM	CD	NumType=Card	_	_	_	_
18	+/-	+/-	SYM	SYM	_	_	_	_	_
19	109	109	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	157	157	NUM	CD	NumType=Card	_	_	_	_
22	+/-	+/-	SYM	SYM	_	_	_	_	_
23	66	66	NUM	CD	NumType=Card	_	_	_	_
24	nmol/L	nmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	P	P	PROPN	NNP	Number=Sing	_	_	_	_
29	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	.01	.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	whereas	whereas	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
39	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	means	means	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
45	-pituitary	-pituitary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
48	axis	axis	NOUN	NN	Number=Sing	_	_	_	_
49	as	as	SCONJ	IN	_	_	_	_	_
50	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	adrenocorticotropic	adrenocorticotropic	ADJ	JJ	Degree=Pos	_	_	_	_
54	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
55	test	test	NOUN	NN	Number=Sing	_	_	_	_
56	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
57	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
58	after	after	ADP	IN	_	_	_	_	_
59	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
60	with	with	ADP	IN	_	_	_	_	_
61	FP	FP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3362
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3363
# text = The results in this study confirm the potency of the inhaled corticosteroid FP and provide evidence for a considerable tissue-specific interindividual variation in the expression of the GR.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	inhaled	inhal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	corticosteroid	corticosteroid	NOUN	NN	Number=Sing	_	_	_	_
13	FP	Fp	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
20	tissue-	tissue-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	interindividual	interindividual	ADJ	JJ	Degree=Pos	_	_	_	_
23	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	GR.	GR.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3364
# text = Document 003003454 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003454	003003454	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3365
# text = Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes.
1	Multiple	multiple	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
5	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3366
# text = The transcription factor NF-ATc that controls gene expression in T lymphocytes and embryonic cardiac cells is expressed in three prominent isoforms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	three	three	NUM	CD	NumType=Card	_	_	_	_
22	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
23	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3367
# text = This is due to alternative splice/polyadenylation events that lead to the predominant synthesis of two long isoforms in naive T cells and a shorter NF-ATc isoform in effector T cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
6	splice	splice	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
19	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	shorter	shorter	NOUN	NN	Number=Sing	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
30	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3368
# text = Whereas the previously described isoform NF-ATc/A contains a relatively short C terminus, the longer isoforms, B and C, span extra C-terminal peptides of 128 and 246 aa, respectively.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	ATc/	Atc/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	A	a	NOUN	NN	Number=Sing	_	_	_	_
10	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	relatively	relatively	ADV	RB	_	_	_	_	_
13	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
14	C	c	PROPN	NNP	Number=Sing	_	_	_	_
15	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	longer	longer	ADJ	JJR	Degree=Cmp	_	_	_	_
19	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	span	span	ADJ	JJ	Degree=Pos	_	_	_	_
26	extra	extra	ADJ	JJ	Degree=Pos	_	_	_	_
27	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
30	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	128	128	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	246	246	NUM	CD	NumType=Card	_	_	_	_
35	aa	aa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3369
# text = We show here that in addition to the strong N-terminal trans-activation domain, TAD-A, which is common to all three NF-ATc isoforms, NF-ATc/C contains a second trans-activation domain, TAD-B, in its C-terminal peptide.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
10	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	trans-	trans-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	all	all	DET	DT	_	_	_	_	_
25	three	three	NUM	CD	NumType=Card	_	_	_	_
26	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	ATc	ATc	NOUN	NN	Number=Sing	_	_	_	_
29	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	ATc/	ATcith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
34	C	C	PROPN	NNP	Number=Sing	_	_	_	_
35	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
38	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
48	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
50	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3370
# text = Various stimuli of T cells that induce the activity of TAD-A also enhance the activity of TAD-B, but, unlike TAD-A, TAD-B remains unphosphorylated by protein from 12-O-tetradecanoyl 12-phorbol 13-acetate-stimulated T cells.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TAD	TAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	A	A	PROPN	NNP	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	enhance	enhance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	unlike	unlike	ADP	IN	_	_	_	_	_
26	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	remains	remains	NOUN	NNS	Number=Plur	_	_	_	_
34	unphosphorylated	unphosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	tetradecanoyl	tetradecanoyl	NOUN	NN	Number=Sing	_	_	_	_
43	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
45	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
46	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	T	t	PROPN	NNP	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3371
# text = The shorter C-terminal peptide of isoform NF-ATc/B exerts a suppressive transcriptional effect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	shorter	shorter	NOUN	NN	Number=Sing	_	_	_	_
3	C-	C-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
8	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	ATc/	ATc/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3372
# text = These properties of NF-ATc/B and -C might be of importance for gene regulation in naive T lymphocytes in which NF-ATc/B and -C are predominantly synthesized.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	ATc/B	ATc/B	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	C	C	PROPN	NNP	Number=Sing	_	_	_	_
10	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	ATc/B	ATc/B	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	C	C	PROPN	NNP	Number=Sing	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	predominantly	predominantly	ADV	RB	_	_	_	_	_
31	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3373
# text = Document 003003456 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003456	003003456	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3374
# text = Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth inhibition in EBV-positive B cells.
1	Latent	Latent	ADJ	JJ	Degree=Pos	_	_	_	_
2	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	cyclin	cyclin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	D2	D2	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	pRb	pRb	NOUN	NN	Number=Sing	_	_	_	_
12	hyperphosphorylation	hyperphosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	loss	loss	ADP	IN	_	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
24	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3375
# text = The normal cell cycle is regulated by several molecules, such as the tumor-suppressor protein pRb, the G1 cyclins, the cyclin-dependent kinases, and their inhibitors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	pRb	pRb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
22	cyclins	cyclin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3376
# text = These regulators are targeted by negative growth regulatory signals, such as that provided by TGF-beta.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3377
# text = Here, we show that the presence of either wild-type EBV or its transforming latent membrane protein-1 (LMP-1) results in the loss of TGF-beta 1-mediated growth inhibition in human B cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	EBV	Ebv	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
17	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
18	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-1	-1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LMP	Lmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	results	result	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
38	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3378
# text = Chemical cross-linking with 125I-labeled TGF-beta 1 showed an essentially normal TGF-beta receptor profile in EBV-positive and EBV-negative Burkitt's lymphoma cell lines, and these receptors were shown to be functional in transducing signals, as evidenced by the TGF-beta 1-mediated modulation of junB gene expression.
1	Chemical	Chemical	PROPN	NNP	Number=Sing	_	_	_	_
2	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	125I	125I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	essentially	essentially	ADV	RB	_	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	's	's	PART	POS	_	_	_	_	_
31	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
42	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
43	in	in	SCONJ	IN	_	_	_	_	_
44	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
45	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	as	as	SCONJ	IN	_	_	_	_	_
48	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
54	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
60	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
61	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3379
# text = However, TGF-beta 1 did not induce dephosphorylation of pRb in EBV (or LMP-1)-positive cells as opposed to EBV-negative cells, suggesting a dichotomy in the TGF-beta 1 signaling pathway leading to separable gene regulatory and growth inhibitory responses.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	pRb	pRb	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	or	or	CCONJ	CC	_	_	_	_	_
17	LMP	Lmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	opposed	oppose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dichotomy	dichotomy	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
42	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
43	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	separable	separable	ADJ	JJ	Degree=Pos	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	regulatory	regulatory	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
50	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
51	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3380
# text = Furthermore, LMP-1 was found to induce the expression of cyclin D2; normal B cells or EBV-negative Burkitt's lymphoma cells do not express D-type cyclins.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
14	D2	d2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
23	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	's	's	PART	POS	_	_	_	_	_
25	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
30	D-	D-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	type	type	NOUN	NN	Number=Sing	_	_	_	_
32	cyclins	cyclin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3381
# text = Taken together, these data point to a potential mechanism underlying EBV-mediated B cell transformation whereby constitutive induction of key cell cycle regulators by LMP-1 can lead to pRb hyperphosphorylation and uncontrolled cell proliferation.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	point	point	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
10	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
11	underlying	underlying	VERB	VBG	VerbForm=Ger	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
18	whereby	whereby	ADP	IN	_	_	_	_	_
19	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
31	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	pRb	pRb	VERB	VB	VerbForm=Inf	_	_	_	_
34	hyperphosphorylation	hyperphosphorylation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	uncontrolled	uncontroll	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3382
# text = Document 003003457 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003457	003003457	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3383
# text = Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line.
1	Cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	12	12	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3384
# text = Interferon-gamma (IFN-gamma) is an important immunoregulatory protein produced predominantly by T cells and large granular lymphocytes (LGL) in response to different extracellular signals.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	predominantly	predominantly	ADV	RB	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
21	granular	granular	ADJ	JJ	Degree=Pos	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	LGL	LGL	INTJ	UH	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
30	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
31	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3385
# text = In particular, two interleukins (ILs), IL-2 and IL-12, have been shown to be potent inducers of IFN-gamma gene expression in both T cells and LGL.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	interleukins	interleukin	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ILs	ILs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
24	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	both	both	DET	DT	_	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	LGL	LGL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3386
# text = Although it has been reported that there are some T cell lines that produce IFN-gamma in response to IL-2 and IL-12 stimulation, there has as yet been no report of a natural killer (NK) cell line that responds in a similar manner.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	there	there	PRON	EX	_	_	_	_	_
8	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	some	some	DET	DT	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	12	12	NUM	CD	NumType=Card	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	there	there	PRON	EX	_	_	_	_	_
31	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	yet	yet	CCONJ	CC	_	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	no	no	DET	DT	_	_	_	_	_
36	report	report	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
40	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
45	line	line	NOUN	NN	Number=Sing	_	_	_	_
46	that	that	PRON	WDT	PronType=Rel	_	_	_	_
47	responds	respond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
51	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3387
# text = In this report we present evidence that the cell line NK3.3 derived from human NK cells, responds to both IL-2 and IL-12, as measured by increases in IFN-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) cytoplasmic mRNA and protein expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	NK3.3	NK3.3	NUM	CD	NumType=Card	_	_	_	_
12	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	responds	respond	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
41	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
51	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
54	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3388
# text = In addition, when used together IL-2 and IL-12 synergized in the induction of IFN-gamma and GM-CSF and this synergy was attributed to an increased accumulation and stability of the IFN-gamma and GM-CSF mRNAs.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	when	when	ADV	WRB	PronType=Int	_	_	_	_
5	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	together	together	ADV	RB	_	_	_	_	_
7	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	12	12	NUM	CD	NumType=Card	_	_	_	_
14	synergized	synergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
46	mRNAs	mRNA	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3389
# text = To investigate the signaling pathways involved in the gene induction, five inhibitors, cyclosporin A (CsA), transforming growth factor-beta, cycloheximide, genistein, and staurosporine A, were used in analyzing the effects of IL-2 and IL-12 on NK3.3 cells.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	five	five	NUM	CD	NumType=Card	_	_	_	_
13	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
16	A	a	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	_
33	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	SCONJ	IN	_	_	_	_	_
38	analyzing	analyze	VERB	VBG	VerbForm=Ger	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	12	12	NUM	CD	NumType=Card	_	_	_	_
49	on	on	ADP	IN	_	_	_	_	_
50	NK3.3	NK3.3	NUM	CD	NumType=Card	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3390
# text = The results suggest that activation of protein kinase C, but not new protein synthesis, is required for IL-2 induction of IFN-gamma and GM-CSF cytoplasmic mRNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
32	cytoplasmic	cytoplasmic	PROPN	NNP	Number=Sing	_	_	_	_
33	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3391
# text = In contrast, IL-12 induction of IFN-gamma cytoplasmic mRNA appears to only partially depend on activation of protein kinase C. Furthermore, both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor, could suppress IL-2 and IL-12 signaling but CsA was generally inactive.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	gamma	gamma	X	FW	Foreign=Yes	_	_	_	_
12	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	partially	partially	ADV	RB	_	_	_	_	_
18	depend	depend	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
25	Furthermore	Furthermore	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
42	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	12	12	NUM	CD	NumType=Card	_	_	_	_
50	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
51	but	but	CCONJ	CC	_	_	_	_	_
52	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
53	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
54	generally	generally	ADV	RB	_	_	_	_	_
55	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3392
# text = It also was observed that suppression of cytokine gene expression by these agents was independent of the inhibition of proliferation.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3393
# text = In addition, IL-2 but not IL-12 induced nuclear factors NF-kappa B and AP1, and regulation of the nuclear levels of these two DNA binding protein complexes is correlated with IFN-gamma and GM-CSF gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	AP1	Ap1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3394
# text = These data indicate that IL-2 and IL-12 may have distinct signaling pathways leading to the induction of IFN-gamma and GM-CSF gene expression, and that the NK3.3 cell line may serve as a novel model for dissecting the biochemical and molecular events involved in these pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NK3.3	NK3.3	NOUN	NN	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	line	line	NOUN	NN	Number=Sing	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
40	as	as	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
43	model	model	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	SCONJ	IN	_	_	_	_	_
45	dissecting	dissect	VERB	VBG	VerbForm=Ger	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
50	events	event	NOUN	NNS	Number=Plur	_	_	_	_
51	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3395
# text = Document 003003458 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003458	003003458	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3396
# text = Jeg-3 human choriocarcinoma-induced immunosuppression: downregulation of interleukin-2, interleukin-2 receptor alpha-chain, and its Jak/Stat signaling pathway.
1	Jeg	Jeg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	choriocarcinoma	choriocarcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	alpha-	alpha-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
27	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
28	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3397
# text = PROBLEM: The mechanisms of the immunosuppressive and immunosuppression-inducing capacities of Jeg-3 human choriocarcinoma cell line supernatants (HCSs) are not yet completely understood.
1	PROBLEM	problem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	capacities	capacitie	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Jeg	Jeg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	choriocarcinoma	choriocarcinoma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HCSs	HCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	yet	yet	ADV	RB	_	_	_	_	_
28	completely	completely	ADV	RB	_	_	_	_	_
29	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3398
# text = The influence on interleukin (IL)-2, IL-4 and interferon (IFN)-gamma production; IL-2 receptor (IL-2R) alpha-, beta-, and gamma-chain; and the signaling pathway molecules Janus kinase (Jak)1, Jak3, signal transducers and activators of transcription (Stat)1, Stat3, and Stat5 should be investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2R	2R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
46	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
47	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
48	Janus	Janus	CCONJ	CC	_	_	_	_	_
49	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
58	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
66	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	_
72	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
73	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
74	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
75	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3399
# text = METHOD OF STUDY:
1	METHOD	method	NOUN	NN	Number=Sing	_	_	_	_
2	OF	of	ADP	IN	_	_	_	_	_
3	STUDY	study	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3400
# text = For assessment of IL production, whole peripheral venous blood from healthy donors was stimulated with phorbol-myristate-acetate and ionomycine.
1	For	for	ADP	IN	_	_	_	_	_
2	assessment	assessment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	venous	venous	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
13	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	ionomycine	ionomycine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3401
# text = Secretion of ILs was blocked with monensine.
1	Secretion	Secretion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ILs	ILs	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	monensine	monensine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3402
# text = Intracellular ILs were analyzed by flow cytometry.
1	Intracellular	Intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	ILs	IL	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
7	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3403
# text = For IL-2R and signaling pathway molecule analysis, peripheral blood lymphocytes were stimulated with phytohemagglutinin (PHA).
1	For	for	ADP	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	R	r	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
10	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PHA	PHA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3404
# text = IL-2R chains were measured by flow cytometry, and Jaks/Stats by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	R	r	ADJ	JJR	Degree=Cmp	_	_	_	_
5	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
10	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Jaks	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Stats	Stat	PROPN	NNPS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
18	dodecyl	dodecyl	NOUN	NN	Number=Sing	_	_	_	_
19	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
20	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
21	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
22	electrophoresis	electrophoresis	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	SDS	sDs	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	PAGE	page	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
30	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3405
# text = RESULTS: Phorbol-myristate-acetate and ionomycine strongly increase the percent-age of IL-2+ cells; an additional 50% HCSs significantly suppresses the percentage to, or below the level of unstimulated cells.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	ionomycine	ionomycine	PRON	PRP	_	_	_	_	_
10	strongly	strongly	ADV	RB	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	percent	percent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	age	age	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
25	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	HCSs	HCSs	PROPN	NNPS	Number=Plur	_	_	_	_
28	significantly	significantly	ADV	RB	_	_	_	_	_
29	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	below	below	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	level	level	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3406
# text = IFN-gamma production is strongly decreased by HCSs in some cases, but not in others.
1	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	strongly	strongly	ADV	RB	_	_	_	_	_
7	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	HCSs	HCS	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	some	some	DET	DT	_	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3407
# text = PHA stimulates IL-2R alpha-, beta-, and gamma-chain expression and their signaling pathway molecules Jak1, Jak3, Stat1, Stat3, and Stat5.
1	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
2	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
22	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Stat1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3408
# text = 50% HCS downregulates the alpha-chain and slightly upregulates the beta-chain.
1	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	%	%	SYM	NN	Number=Sing	_	_	_	_
3	HCS	HCS	PROPN	NNP	Number=Sing	_	_	_	_
4	downregulates	downregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	slightly	slightly	ADV	RB	_	_	_	_	_
10	upregulates	upregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3409
# text = Jak1, Jak3, Stat1, Stat3, and Stat5 expression is suppressed approximately to, or below the level of unstimulated cells.
1	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Stat1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	below	below	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3410
# text = CONCLUSIONS: HCS forcefully blocks the production of IL-2; the IL-2R alpha-chain; and Jak1, Jak3, Stat1, Stat3, and Stat5 expression.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	HCS	Hc	NOUN	NNS	Number=Plur	_	_	_	_
4	forcefully	forcefully	ADV	RB	_	_	_	_	_
5	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
17	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Stat1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3411
# text = The observed phenomena might be caused by downregulation of an IL-2R regulation gene, and might play a key role in the expansion of choriocarcinoma, and possibly in the survival of the fetal allograft.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
3	phenomena	phenomena	NOUN	NN	Number=Sing	_	_	_	_
4	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
19	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	choriocarcinoma	choriocarcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	possibly	possibly	ADV	RB	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
37	allograft	allograft	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3412
# text = Document 003003459 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003459	003003459	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3413
# text = Signal transduction through interferon-gamma receptor on human eosinophils.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3414
# text = BACKGROUND:
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3415
# text = We reported on the constitutive interferon-gamma receptor (IFN-gammaR) expression on eosinophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gammaR	gammar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3416
# text = But signal transduction through IFN-gammaR on eosinophils remains to be elucidated.
1	But	but	CCONJ	CC	_	_	_	_	_
2	signal	signal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	through	through	ADP	IN	_	_	_	_	_
5	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gammaR	gammar	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
10	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3417
# text = In this study, we examined the involvement of the Jak/Stat pathway in the signaling of eosinophils after IFN-gammaR conjugation by the ligand binding.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gammaR	gammaR	PROPN	NNP	Number=Sing	_	_	_	_
24	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3418
# text = METHODS: Purified peripheral eosinophils were stimulated with IFN-gamma at 37 degrees C for 1-60 min.
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Purified	Purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	37	37	NUM	CD	NumType=Card	_	_	_	_
14	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
15	C	C	PROPN	NNP	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	60	60	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3419
# text = Tyrosine phosphorylation of IFN-gammaR, Jak1, Jak2, and Stat1alpha was examined by immunoblotting.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gammaR	gammaR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Jak2	jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3420
# text = Gel-shift assay was also examined to show the formation of Stat1alpha-DNA complexes.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3421
# text = RESULTS: We show that binding of IFN-gamma to human eosinophils initiated a series of events that resulted in the rapid tyrosine phosphorylation of not only the IFN-gammaRalpha chain but also Jak1, Jak2, and Stat1alpha.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
14	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	series	series	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	events	event	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
24	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	not	not	ADV	RB	_	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	gammaRalpha	gammaRalpha	PROPN	NNP	Number=Sing	_	_	_	_
33	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	also	also	ADV	RB	_	_	_	_	_
36	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	Jak2	Jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3422
# text = In addition, IFN-gamma enhanced the DNA-binding activity of Stat1alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3423
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3424
# text = These data indicate that IFN-gamma affects eosinophils through its specific receptor and utilizes the Jak/Stat pathway as its mode of signaling.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	affects	affect	NOUN	NNS	Number=Plur	_	_	_	_
9	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	utilizes	utilize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3425
# text = Document 003003462 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003462	003003462	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3426
# text = Ras oncogene transformation of human B lymphoblasts is associated with lymphocyte activation and with a block of differentiation.
1	Ras	Ras	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
2	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
3	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	lymphoblasts	lymphoblast	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	block	block	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3427
# text = The p21ras small GTP binding proteins participate in signal transduction from cell surface receptors and affect neoplastic transformation and development in many different cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
3	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
4	GTP	Gtp	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	affect	affect	ADJ	JJ	Degree=Pos	_	_	_	_
17	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
18	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	development	development	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3428
# text = In the present study, we examined the relationship between ras transformation and differentiation of human B lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	ras	ras	NOUN	NN	Number=Sing	_	_	_	_
12	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3429
# text = We show that the constitutive expression of the T24 Ha-ras oncogene in EBV-immortalized B lymphoblasts was associated with the induction of the interleukin 2 receptor alpha subunit, with an impaired immunoglobulin gene expression, altered adhesion properties and increased survival in serum-free medium.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T24	t24	NUM	CD	NumType=Card	_	_	_	_
10	Ha-	Ha-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
12	oncogene	oncogene	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	lymphoblasts	lymphoblast	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	alpha	alpha	ADP	IN	_	_	_	_	_
30	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
41	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
49	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3430
# text = Since induction of the IL-2 receptor alpha subunit is a hallmark of lymphocyte activation, we suggest that p21ras naturally triggers B cell activation.
1	Since	since	ADP	IN	_	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	hallmark	hallmark	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	p21ras	p21ras	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	naturally	naturally	ADV	RB	_	_	_	_	_
23	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3431
# text = The ras-transformed lymphocytes displayed a fully functional IL-2r, as assessed by c-fos induction following treatment with IL-2; nevertheless, they were not growth stimulated by this lymphokine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	fully	fully	ADV	RB	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2r	2r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	growth	growth	ADV	RB	_	_	_	_	_
34	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3432
# text = The decreased expression of immunoglobulin genes indicates that the ras oncogene blocks terminal differentiation to plasma cells, possibly by inhibiting the activity of lymphocyte-specific transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
11	oncogene	oncogene	PRON	PRP	_	_	_	_	_
12	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
13	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	possibly	possibly	ADV	RB	_	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3433
# text = Somewhat unexpectedly, the constitutive p21ras activity did not cause an increased DNA binding of transcription factors PEA1 (AP1), PEA3, Oct-2 or NF-kB.
1	Somewhat	somewhat	ADV	RB	_	_	_	_	_
2	unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	PEA1	PEA1	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	PEA3	PEA3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kB.	kB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3434
# text = Document 003003463 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003463	003003463	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3435
# text = Inhibition of dexamethasone binding to human glucocorticoid receptor by New World primate cell extracts.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	New	New	PROPN	NNP	Number=Sing	_	_	_	_
11	World	World	PROPN	NNP	Number=Sing	_	_	_	_
12	primate	primate	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3436
# text = To determine if New World primates express an inhibitor that influences glucocorticoid receptor (GR) binding characteristics, we examined [3H]dexamethasone binding in cytosol prepared from B95-8 lymphoid cells, derived from the cotton top tamarin (Saguinus oedipus), in combination with cytosol prepared from human or rat tissues.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	if	if	SCONJ	IN	_	_	_	_	_
4	New	New	PROPN	NNP	Number=Sing	_	_	_	_
5	World	world	PROPN	NNP	Number=Sing	_	_	_	_
6	primates	primate	NOUN	NNS	Number=Plur	_	_	_	_
7	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	3H]	3h]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
28	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	B95	B95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	8	8	NUM	CD	NumType=Card	_	_	_	_
33	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cotton	cotton	NOUN	NN	Number=Sing	_	_	_	_
40	top	top	NOUN	NN	Number=Sing	_	_	_	_
41	tamarin	tamarin	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	Saguinus	Saguinus	ADJ	JJ	Degree=Pos	_	_	_	_
44	oedipus	oedipus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
51	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	from	from	ADP	IN	_	_	_	_	_
53	human	human	NOUN	NN	Number=Sing	_	_	_	_
54	or	or	CCONJ	CC	_	_	_	_	_
55	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
56	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3437
# text = B95-8 cytosol inhibited specific binding of [3H]dexamethasone (P < 0.01) when mixed with cytosol prepared from either a human lymphoid cell line (HL) or rat thymus.
1	B95	B95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	8	8	NUM	CD	NumType=Card	_	_	_	_
4	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	3H	3H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	P	p	NOUN	NN	Number=Sing	_	_	_	_
15	<	<	PUNCT	-LRB-	_	_	_	_	_
16	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
22	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	either	either	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
35	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3438
# text = The inhibitory activity was heat labile and trypsin sensitive.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
6	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	trypsin	trypsin	VERB	VB	VerbForm=Inf	_	_	_	_
9	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3439
# text = Peak inhibitory activity was found in the 150-200 kd fractions after Sephacryl G-200 ultrafiltration.
1	Peak	peak	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	150	150	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	200	200	NUM	CD	NumType=Card	_	_	_	_
11	kd	k	ADJ	JJ	Degree=Pos	_	_	_	_
12	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	Sephacryl	Sephacryl	PROPN	NNP	Number=Sing	_	_	_	_
15	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	200	200	NUM	CD	NumType=Card	_	_	_	_
18	ultrafiltration	ultrafiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3440
# text = Scatchard analysis of [3H]dexamethasone binding using mixed cytosol showed a diminished GR apparent binding affinity when compared to HL cytosol.
1	Scatchard	Scatchard	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	3H	3H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
10	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
16	apparent	apparent	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	HL	Hl	PROPN	NNP	Number=Sing	_	_	_	_
23	cytosol	cytosol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3441
# text = Kinetic studies using mixed cytosol indicated that B95-8 cytosol did not affect the apparent dissociation rate of [3H]dexamethasone.
1	Kinetic	Kinetic	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
6	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	B95	B95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
17	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
18	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	3H]	3h]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3442
# text = These data demonstrate that B95-8 cells contain a competitive inhibitor that prevents binding of dexamethasone to its cognate receptor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	B95	B95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	8	8	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3443
# text = Document 003003465 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003465	003003465	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3444
# text = Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT.
1	Age	age	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3445
# text = Although transcriptional factors AP-1 and nuclear factor of activated T cells (NF-AT) are important for the normal induction of IL-2, it is unknown if the age-related decline in IL-2 production by activated human T cells may be associated with aberrancies in transcriptional regulatory proteins.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
33	if	if	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
38	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	production	production	NOUN	NN	Number=Sing	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
50	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
51	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	with	with	ADP	IN	_	_	_	_	_
53	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
56	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
57	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3446
# text = In the current studies, IL-2 production by T cells from elderly (mean 78 years) and young (mean 37 years) humans was measured in cultures stimulated with PHA, PHA plus PMA, crosslinked anti-CD3 mAB OKT3 plus PMA, or PMA plus ionomycin.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	elderly	elderly	ADV	RB	_	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	mean	mean	VERB	VB	VerbForm=Inf	_	_	_	_
17	78	78	NUM	CD	NumType=Card	_	_	_	_
18	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	young	young	ADV	RB	_	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	mean	mean	VERB	VB	VerbForm=Inf	_	_	_	_
24	37	37	NUM	CD	NumType=Card	_	_	_	_
25	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
37	plus	plus	CCONJ	CC	_	_	_	_	_
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	crosslinked	crosslink	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
42	mAB	mab	NOUN	NN	Number=Sing	_	_	_	_
43	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	_
44	plus	plus	CCONJ	CC	_	_	_	_	_
45	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	or	or	CCONJ	CC	_	_	_	_	_
48	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
49	plus	plus	CCONJ	CC	_	_	_	_	_
50	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3447
# text = Substantial decreases of IL-2 production were observed for cell cultures from 7 of 12 elderly individuals in response to the different stimuli, whereas the levels of IL-2 produced by stimulated T cells from other elderly individuals were equivalent to those observed for stimulated T cells of young subjects.
1	Substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
2	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	7	7	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	_
17	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
40	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
41	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
42	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
46	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
53	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3448
# text = Analyses of nuclear extracts by electrophoretic DNA mobility shift assays showed that decreased IL-2 production by stimulated T cells of elderly individuals was closely associated with impairments in the activation of both AP-1 and NF-AT.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
9	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
10	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	closely	closely	ADV	RB	_	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	both	both	DET	DT	_	_	_	_	_
35	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3449
# text = By contrast, T cells from elderly subjects with normal levels of IL-2 production exhibited normal activation of AP-1 and NF-AT.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	t	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
8	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3450
# text = In addition, the results of competition experiments analyzing the normal components of NF-AT showed that the age-related reductions in stimulus-dependent NF-AT complexes corresponded to the slow migrating complexes that were composed of c-Fos/c-Jun AP-1.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
9	analyzing	analyze	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	components	component	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
17	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	reductions	reduction	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
31	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
32	corresponded	correspond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
36	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
37	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-Jun	-Jun	PROPN	NNP	Number=Sing	_	_	_	_
44	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3451
# text = The resting and stimulated levels of NF kappa B were reduced in T cells from certain elderly individuals; however, alterations of NF kappa B did not correlate with changes in IL-2 expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	resting	resting	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
17	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	B	PROPN	NNP	Number=Sing	_	_	_	_
27	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3452
# text = Thus, these results show that age-related impairments in the activation of AP-1 and NF-AT are closely associated with decreased expression of IL-2 and further suggest that aberrancies in the signaling pathways important for the induction of transcriptionally active c-Fos/c-Jun AP-1 may contribute to the impaired activation of NF-AT.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	at	NOUN	NN	Number=Sing	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	closely	closely	ADV	RB	_	_	_	_	_
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	further	further	ADV	RB	_	_	_	_	_
34	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
40	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
41	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
47	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
48	c-Fos/c	c-Fos/c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
49	-Jun	-Jun	NOUN	NN	Number=Sing	_	_	_	_
50	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	1	1	NUM	CD	NumType=Card	_	_	_	_
53	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
54	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
55	to	to	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
59	of	of	ADP	IN	_	_	_	_	_
60	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3453
# text = Document 003003469 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003469	003003469	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3454
# text = Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).
1	Dimerization	Dimerization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	KB2	Kb2	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3455
# text = Inducible expression of human immunodeficiency virus (HIV) is regulated by a cellular transcription factor, nuclear factor kappa B (NF-kappa B).
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3456
# text = NF-kappa B is composed of distinct subunits; five independent genes, NFKB1(p105), NFKB2(p100), RelA(p65), c-rel and relB, that encode related proteins that bind to kappa B DNA elements have been isolated.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	five	five	NUM	CD	NumType=Card	_	_	_	_
12	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	NFKB1	NFKB1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	p100	p100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	relB	relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	encode	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	that	that	PRON	WDT	PronType=Rel	_	_	_	_
40	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
45	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
46	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3457
# text = We have previously found that NFKB2(p49/p52) acts in concert with RelA(p65) to stimulate the HIV enhancer in Jurkat T-leukemia cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p49/	p49/	SYM	SYM	_	_	_	_	SpaceAfter=No
9	p52	p52	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3458
# text = Here we examine the biochemical basis for the transcriptional regulation of HIV by NFKB2.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	examine	examine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
6	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3459
# text = Using Scatchard analysis, we have determined the dissociation constants of homodimeric p49 and heterodimeric p49/p65 for binding to the HIV kappa B site.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	Scatchard	Scatchard	PROPN	NNP	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
10	constants	constant	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	homodimeric	homodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
13	p49	p49	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
16	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3460
# text = p49 has a approximately 18-fold-lower affinity for the HIV kappa B site (KD = 69.1 pM)
1	p49	p49	NOUN	NN	Number=Sing	_	_	_	_
2	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	lower	lower	ADJ	JJ	Degree=Pos	_	_	_	_
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	KD	kd	NOUN	NN	Number=Sing	_	_	_	_
19	=	=	SYM	SYM	_	_	_	_	_
20	69.1	69.1	NUM	CD	NumType=Card	_	_	_	_
21	pM	pm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 3461
# text = than does the approximately 50-kDa protein NFKB1(p50) derived from p105 (KD = 3.9 pM).
1	than	than	ADP	IN	_	_	_	_	_
2	does	do	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	NFKB1	NFKB1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	KD	kd	NOUN	NN	Number=Sing	_	_	_	_
18	=	=	SYM	SYM	_	_	_	_	_
19	3.9	3.9	NUM	CD	NumType=Card	_	_	_	_
20	pM	pm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3462
# text = In contrast, the affinity of heterodimeric NFKB2(p49)/RelA(p65) for this site is approximately 6-fold higher (KD = 11.8 pM) than that of p49 alone.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
8	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	p49	p49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	p65	p65	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	approximately	approximately	ADV	RB	_	_	_	_	_
22	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	KD	K	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
28	=	=	SYM	SYM	_	_	_	_	_
29	11.8	11.8	NUM	CD	NumType=Card	_	_	_	_
30	pM	pm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	than	than	ADP	IN	_	_	_	_	_
33	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	p49	p49	NUM	CD	NumType=Card	_	_	_	_
36	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3463
# text = Consistent with these findings, in vitro transcription was stimulated 18-fold by the addition of preformed, heterodimeric NFKB2(p49)/RelA(p65) protein.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	preformed	preformed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
21	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	p49	p49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3464
# text = Transcriptional activation of the HIV enhancer was also subject to regulation by recently cloned I kappa B-alpha(MAD-3).
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	regulation	regulation	VERB	VB	VerbForm=Inf	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	recently	recently	ADV	RB	_	_	_	_	_
14	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	X	GW	_	_	_	_	_
17	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
18	alpha	alpha	X	GW	_	_	_	_	SpaceAfter=No
19	(	(	X	GW	_	_	_	_	SpaceAfter=No
20	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3465
# text = Recombinant
1	Recombinant	Recombinant	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3466
# text = I kappa B-alpha(MAD-3) inhibited the DNA binding activity of p65, p49/p65, and p50/p65 but stimulated the binding of NFKB2(p49) or NFKB1(p50).
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	p49/	p49/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
20	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	NFKB1	NFKB1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3467
# text = Functional activation of an HIV reporter plasmid by p49/p65 in transiently transfected Jurkat T-leukemia cells was also inhibited by coexpression of MAD-3.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
6	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
7	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	p49	p49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	transiently	transiently	ADV	RB	_	_	_	_	_
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
16	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3468
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3469
# text = Document 003003471 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003471	003003471	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3470
# text = Interferon-alpha induction of STATs1, -3 DNA binding and growth arrest is independent of Lck and active mitogen-activated kinase in T cells.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STATs1	STATs1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
14	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3471
# text = Type I interferons (IFNs) are a family of cytokines that have antiviral and antiproliferative effects.
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFNs	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3472
# text = Data regarding the processes by which these cytokines transduce signals from the cell membrane to the nucleus are becoming increasingly complex.
1	Data	data	PROPN	NNP	Number=Sing	_	_	_	_
2	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	transduce	transduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	becoming	become	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
20	increasingly	increasingly	ADV	RB	_	_	_	_	_
21	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3473
# text = The most characterized pathway is via JAK-STAT signaling.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	most	most	ADV	RBS	_	_	_	_	_
3	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	via	via	ADP	IN	_	_	_	_	_
7	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3474
# text = Previous studies established a potential role for the Src-family kinase Lck in JAK-STAT signaling.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Src-	src-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3475
# text = Therefore, this study was designed to analyze the role of Lck in IFN-alpha signaling by using the Jurkat, JCam (an Lck-defective cell line derived from Jurkat), and JCam/Lck (JCam cells with Lck restored).
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	JCam	JCam	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	Lck-defective	Lck-defective	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	JC	JC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	am	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	JCam	JCam	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
44	restored	restore	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3476
# text = The results show that IFN-alpha can induce MAPK activity, but only in cells containing Lck. Furthermore, STATs1 and -3 are effectively phosphorylated and activated to bind DNA in the absence of Lck expression in IFN-alpha-treated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
18	Lck.	Lck.	PROPN	NNP	Number=Sing	_	_	_	_
19	Furthermore	Furthermore	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	STATs1	STATs1	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	3	3	X	LS	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	effectively	effectively	ADV	RB	_	_	_	_	_
27	phosphorylated	phosphorylated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3477
# text = Finally, the results demonstrate that IFN-alpha exerts an antiproliferative effect in all three cell lines.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3478
# text = These data indicate that Lck and active MAPK do not affect IFN-alpha-induced growth arrest or induction of STAT1s1 and -3 DNA binding ability.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	MAPK	Mapk	PROPN	NNP	Number=Sing	_	_	_	_
9	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
12	IFN	Ifn	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha-induced	alpha-induced	ADJ	JJ	Degree=Pos	_	_	_	_
15	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
16	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	STAT1s1	STAT1s1	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	ability	ability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3479
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3480
# text = Document 003003473 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003473	003003473	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3481
# text = Evidence for a polyclonal etiology of palmar fibromatosis.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	palmar	palmar	NOUN	NN	Number=Sing	_	_	_	_
8	fibromatosis	fibromatosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3482
# text = X chromosome inactivation patterns at the androgen receptor locus were evaluated to determine clonality in microdissected lesional tissue and in leukocytes from 2 women with Dupuytren's disease.
1	X	x	ADP	IN	_	_	_	_	_
2	chromosome	chromosome	DET	DT	_	_	_	_	_
3	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
4	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
14	clonality	clonality	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	microdissected	microdissect	ADJ	JJ	Degree=Pos	_	_	_	_
17	lesional	lesional	ADJ	JJ	Degree=Pos	_	_	_	_
18	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	Dupuytren	Dupuytren	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	's	's	PART	POS	_	_	_	_	_
28	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3483
# text = The tissue from both patients generated a polyclonal pattern of X chromosome inactivation of the human androgen receptor gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
6	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	X	x	ADJ	JJ	Degree=Pos	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3484
# text = This finding supports a polyclonal reactive process as the underlying etiology for palmar fibromatosis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
7	process	process	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	underlying	underly	ADJ	JJ	Degree=Pos	_	_	_	_
11	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	palmar	palmar	NOUN	NN	Number=Sing	_	_	_	_
14	fibromatosis	fibromatosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3485
# text = Document 003003476 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003476	003003476	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3486
# text = Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1.
1	Comparative	Comparative	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	identifies	identify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	conserved	conserve	ADJ	JJ	Degree=Pos	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
20	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	oncogene	oncogene	PROPN	NNP	Number=Sing	_	_	_	_
25	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3487
# text = Nonhuman primates are naturally infected with a B-lymphotropic herpesvirus closely related to Epstein-Barr virus (EBV).
1	Nonhuman	Nonhuman	ADJ	JJ	Degree=Pos	_	_	_	_
2	primates	primate	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	naturally	naturally	ADV	RB	_	_	_	_	_
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
11	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
12	closely	closely	ADV	RB	_	_	_	_	_
13	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3488
# text = These simian EBV share considerable genetic, biologic, and epidemiologic features with human EBV, including virus-induced tumorigenesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
4	share	share	NOUN	NN	Number=Sing	_	_	_	_
5	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
6	genetic	genetic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	biologic	biologic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	epidemiologic	epidemiologic	ADJ	JJ	Degree=Pos	_	_	_	_
12	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	EBV	EBV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-induced	-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	tumorigenesis	tumorigenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3489
# text = However, latent, transformation-associated viral genes demonstrate marked sequence divergence among species despite the conserved functions.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	divergence	divergence	NOUN	NN	Number=Sing	_	_	_	_
14	among	among	ADP	IN	_	_	_	_	_
15	species	species	NOUN	NNS	Number=Plur	_	_	_	_
16	despite	despite	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3490
# text = We have cloned the latent membrane protein 1 (LMP1) homologs from the simian EBV naturally infecting baboons (cercopithicine herpesvirus 12, herpesvirus papio) and rhesus monkeys (cercopithicine herpesvirus 15) for a comparative study with the human EBV oncogene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	homologs	homolog	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
17	naturally	naturally	ADV	RB	_	_	_	_	_
18	infecting	infecte	VERB	VBG	VerbForm=Ger	_	_	_	_
19	baboons	baboon	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	cercopithicine	cercopithicine	NOUN	NN	Number=Sing	_	_	_	_
22	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
26	papio	papio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	rhesus	rhesus	ADJ	JJ	Degree=Pos	_	_	_	_
30	monkeys	monkey	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	cercopithicine	cercopithicine	NOUN	NN	Number=Sing	_	_	_	_
33	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
34	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	comparative	comparative	ADJ	JJ	Degree=Pos	_	_	_	_
39	study	study	NOUN	NN	Number=Sing	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
44	oncogene	oncogene	ADV	RB	_	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3491
# text = The transmembrane domains are well conserved, but there is striking sequence divergence of the carboxy-terminal cytoplasmic domain essential for B-cell immortalization and interaction with the tumor necrosis factor receptor signaling pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
3	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	there	there	PRON	EX	_	_	_	_	_
10	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	divergence	divergence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
19	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
32	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
36	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3492
# text = Nevertheless, the simian EBV LMP1s retain most functions in common with EBV LMP1, including the ability to induce NF-(kappa)B activity in human cells, to bind the tumor necrosis factor-associated factor 3 (TRAF3) in vitro, and to induce expression of tumor necrosis factor-responsive genes, such as ICAM1, in human B lymphocytes.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	1s	1	NOUN	NNS	Number=Plur	_	_	_	_
8	retain	retain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
10	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
15	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	3	3	NUM	CD	NumType=Card	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	TRAF3	TRAF3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	to	to	PART	TO	_	_	_	_	_
50	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
51	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
54	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
55	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
58	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
61	as	as	ADP	IN	_	_	_	_	_
62	ICAM1	ICAM1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	in	in	ADP	IN	_	_	_	_	_
65	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
66	B	b	NOUN	NN	Number=Sing	_	_	_	_
67	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3493
# text = Multiple TRAF3 binding sites containing a PXQXT/S core sequence can be identified in the simian EBV LMP1s by an in vitro binding assay.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	TRAF3	TRAF3	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	PXQXT/	Pxqxt/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	S	's	PART	POS	_	_	_	_	_
9	core	core	NOUN	NN	Number=Sing	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
18	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	1s	1	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	assay	assay	ADV	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3494
# text = A PXQXT/S-containing sequence is also present in the cytoplasmic domain of the Hodgkin's disease marker, CD30, and binds TRAF3 in vitro.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	PXQXT/S	pxqxt/s	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	's	's	PART	POS	_	_	_	_	_
17	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
18	marker	marker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
24	TRAF3	TRAF3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3495
# text = The last 13 amino acids containing a PXQXT/S sequence are highly conserved in human and simian EBV LMP1 but do not bind TRAF3, suggesting a distinct role for this conserved region of LMP1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	last	last	ADJ	JJ	Degree=Pos	_	_	_	_
3	13	13	NUM	CD	NumType=Card	_	_	_	_
4	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
5	acids	acid	SCONJ	IN	_	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	PXQXT/	Pxqxt/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	S	's	PART	POS	_	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	highly	highly	ADV	RB	_	_	_	_	_
13	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
18	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
19	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
24	TRAF3	TRAF3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	conserved	conserved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3496
# text = The conserved TRAF3 binding sites in LMP1 and the CD30 Hodgkin's disease marker provides further evidence that a TRAF3-mediated signal transduction pathway may be important in malignant transformation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	TRAF3	TRAF3	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
11	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	's	's	PART	POS	_	_	_	_	_
13	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
14	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
15	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
17	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	TRAF3	TRAF3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
31	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3497
# text = Document 003003478 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003478	003003478	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3498
# text = Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DR-	dr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	nm23	nm23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	member	member	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nm23	nm23	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
23	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	32Dc13	32Dc13	NUM	CD	NumType=Card	_	_	_	_
26	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3499
# text = Chronic myelogenous leukemia evolves in two clinically distinct stages: a chronic and a blast crisis phase.
1	Chronic	Chronic	ADJ	JJ	Degree=Pos	_	_	_	_
2	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	evolves	evolve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	clinically	clinically	ADV	RB	_	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	chronic	chronic	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
16	crisis	crisis	NOUN	NN	Number=Sing	_	_	_	_
17	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3500
# text = The molecular changes associated with chronic phase to blast crisis transition are largely unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
7	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	blast	blast	VERB	VB	VerbForm=Inf	_	_	_	_
10	crisis	crisis	NOUN	NN	Number=Sing	_	_	_	_
11	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	largely	largely	ADV	RB	_	_	_	_	_
14	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3501
# text = We have identified a cDNA clone, DR-nm23, differentially expressed in a blast-crisis cDNA library, which has approximately 70% sequence similarity to the putative metastatic suppressor genes, nm23-H1 and nm23-H2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
6	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	DR-	dr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	nm23	nm23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	differentially	differentially	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	blast	blast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	crisis	crisis	NOUN	NN	Number=Sing	_	_	_	_
18	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
19	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	approximately	approximately	ADV	RB	_	_	_	_	_
24	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	%	%	SYM	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
31	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
32	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	nm23	nm23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	H1	H1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	nm23	nm23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	H2	H2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3502
# text = The deduced amino acid sequence similarity to the proteins encoded by these two latter genes is approximately 65% and includes domains and amino acid residues (the leucine zipper-like and the RGD domain, a serine and a histidine residue in the NH2- and in the COOH-terminal portion of the protein, respectively) postulated to be important for nm23 function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	deduced	deduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	amino	amino	DET	DT	_	_	_	_	_
4	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	%	%	SYM	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	amino	amino	DET	DT	_	_	_	_	_
25	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
26	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	leucine	leucine	NOUN	NN	Number=Sing	_	_	_	_
30	zipper	zipper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	RGD	RGD	ADJ	JJ	Degree=Pos	_	_	_	_
36	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	histidine	histidine	NOUN	NN	Number=Sing	_	_	_	_
43	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	COOH	COOh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
54	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	to	to	PART	TO	_	_	_	_	_
63	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
64	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
65	for	for	ADP	IN	_	_	_	_	_
66	nm23	nm23	NUM	CD	NumType=Card	_	_	_	_
67	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3503
# text = DR-nm23 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells.
1	DR-	DR-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	nm23	nm23	NUM	CD	NumType=Card	_	_	_	_
3	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	preferentially	preferentially	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	highly	highly	ADV	RB	_	_	_	_	_
15	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3504
# text = Its constitutive expression in the myeloid precursor 32Dc13 cell line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
7	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
8	32Dc13	32Dc13	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	results	result	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
33	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3505
# text = These results are consistent with a role for DR-nm23 in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	DR-	DR-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	nm23	nm23	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	raise	raise	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
21	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	blastic	blastic	ADJ	JJ	Degree=Pos	_	_	_	_
30	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
33	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
34	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3506
# text = Document 003003481 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003481	003003481	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3507
# text = Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ICAM	ICAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	Tax1	Tax1	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	-T-cell	-T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3508
# text = The present study was undertaken to determine the role of HTLV-I TaxI in the up-regulation of ICAM-I and LFA-3 in human T cells transformed with HTLV-I and the mechanism of down-regulation of ICAM-I and LFA-I in ATL-derived cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3509
# text = Induction of TaxI in a human T-cell line Jurkat carrying the TaxI gene under the metallothionein promoter led to increases in mRNA and surface expression of ICAM-I.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	Jurkat	Jurkat	SCONJ	IN	_	_	_	_	_
11	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	under	under	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	metallothionein	metallothionein	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3510
# text = The response of LFA-3 to TaxI induction was, on the other hand, relatively slow and weak, and might be indirect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	relatively	relatively	ADV	RB	_	_	_	_	_
18	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3511
# text = Transactivation of the ICAM-I promoter by TaxI was further shown by co-transfection of a CAT reporter construct with the ICAM-I promoter and a plasmid expressing TaxI.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	further	further	ADV	RB	_	_	_	_	_
12	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
29	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
30	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3512
# text = The mechanism of down-regulation of ICAM-I or LFA-I in 4 ATL cell lines was next examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	next	next	ADV	RB	_	_	_	_	_
22	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3513
# text = ICAM-I mRNA was quite low in MT-I, but no genomic changes were found.
1	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	quite	quite	ADV	RB	_	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	MT	Mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
16	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3514
# text = The CAT reporter with the ICAM-I promoter was inactive in MT-I.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
3	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3515
# text = Finally, combined treatment of MT-I with 5-azacytidine and IFN-gamma induced re-expression of ICAM-I.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	azacytidine	azacytidine	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	re-expression	re-expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3516
# text = Collectively, (a) transcriptional factor(s) necessary for expression of ICAM-I gene may be repressed in MT-I through DNA methylation.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	a	a	X	LS	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	s	s	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	gene	gene	PRON	NN	Number=Sing	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3517
# text = Three other ATL cell lines (TL-OmI, H582, HuT102) were found to have little mRNA for the LFA-I beta chain (CD18).
1	Three	Three	NUM	CD	NumType=Card	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TL	TL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	OmI	OmI	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	H582	H582	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	HuT102	HuT102	X	LS	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
19	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	beta	beof	ADP	IN	Abbr=Yes	_	_	_	_
27	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3518
# text = H582 and HuT102 were also negative for the LFA-I alpha chain (CDIIa) mRNA.
1	H582	H582	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	HuT102	HuT102	NOUN	NN	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	LFA	LFa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CDIIa	CDIIa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3519
# text = No genomic changes were found, and a CAT reporter gene with the CD18 promoter was inactive in the 3 of them, again suggesting lack of (a) transcriptional factor(s) necessary for CD18 expression.
1	No	no	DET	DT	_	_	_	_	_
2	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
10	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	18	18	NUM	CD	NumType=Card	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	again	again	ADV	RB	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	a	a	X	LS	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	s	s	X	AFX	_	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	18	18	NUM	CD	NumType=Card	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3520
# text = Document 003003484 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003484	003003484	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3521
# text = SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.
1	SOCS	sOCs	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
6	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3522
# text = Members of the recently discovered SOCS/CIS/SSI family have been proposed as regulators of cytokine signaling, and while targets and mechanisms have been suggested for some family members, the precise role of these proteins remains to be defined.
1	Members	member	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	recently	recently	ADV	RB	_	_	_	_	_
5	discovered	discovered	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	SOCS/CIS	sOCS/CIs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	SSI	Ssi	PROPN	NNP	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	while	while	SCONJ	IN	_	_	_	_	_
21	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	some	some	DET	DT	_	_	_	_	_
29	family	family	NOUN	NN	Number=Sing	_	_	_	_
30	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
34	role	role	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
38	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3523
# text = To date no SOCS proteins have been specifically implicated in interleukin-2 (IL-2) signaling in T cells.
1	To	to	ADP	IN	_	_	_	_	_
2	date	date	NOUN	NN	Number=Sing	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	SOCS	sOCs	NOUN	NN	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3524
# text = Here we report SOCS-3 expression in response to IL-2 in both T-cell lines and human peripheral blood lymphocytes.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3525
# text = SOCS-3 protein was detectable as early as 30 min following IL-2 stimulation, while CIS was seen only at low levels after 2 h.
1	SOCS	sOCs	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	early	early	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	30	30	NUM	CD	NumType=Card	_	_	_	_
11	min	min	NOUN	NNS	Number=Plur	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	CIS	CIS	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	only	only	ADV	RB	_	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3526
# text = Unlike CIS, SOCS-3 was rapidly tyrosine phosphorylated in response to IL-2.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	CIS	CIS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	rapidly	rapidly	ADV	RB	_	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3527
# text = Tyrosine phosphorylation of SOCS-3 was observed upon coexpression with Jak1 and Jak2 but only weakly with Jak3.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	Jak1	Jak1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	weakly	weakly	ADV	RB	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3528
# text = In these experiments, SOCS-3 associated with Jak1 and inhibited Jak1 phosphorylation, and this inhibition was markedly enhanced by the presence of IL-2 receptor beta chain (IL-2Rbeta).
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	markedly	markedly	ADV	RB	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	Rbeta	Rbeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3529
# text = Moreover, following IL-2 stimulation of T cells, SOCS-3 was able to interact with the IL-2 receptor complex, and in particular tyrosine phosphorylated Jak1 and IL-2Rbeta.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
30	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
31	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3530
# text = Additionally, in lymphocytes expressing SOCS-3 but not CIS, IL-2-induced tyrosine phosphorylation of STAT5b was markedly reduced, while there was only a weak effect on IL-3-mediated STAT5b tyrosine phosphorylation.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
6	SOCS	SOCS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	CIS	Cis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	b	b	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	markedly	markedly	ADV	RB	_	_	_	_	_
25	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	there	there	PRON	EX	_	_	_	_	_
29	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
33	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	b	b	NOUN	NN	Number=Sing	_	_	_	_
42	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
43	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3531
# text = Finally, proliferation induced by both IL-2- and IL-3 was significantly inhibited in the presence of SOCS-3.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3532
# text = The findings suggest that when SOCS-3 is rapidly induced by IL-2 in T cells, it acts to inhibit IL-2 responses in a classical negative feedback loop.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
32	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
33	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3533
# text = Document 003003490 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003490	003003490	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3534
# text = HIV-1 LTR activity in human CD40-activated B lymphocytes is dependent on NF-kappaB.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-activated	-activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 3535
# text = CD40-stimulated human B lymphocytes are highly permissive to a productive infection by the human immunodeficiency virus type 1.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-stimulated	-stimulated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	highly	highly	ADV	RB	_	_	_	_	_
8	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3536
# text = In these cells, nuclear factors involved in activation of the HIV-1 LTR, which contains the transcriptional control elements of the virus, are unknown.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	control	control	NOUN	NN	Number=Sing	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3537
# text = Transient expression assays with plasmids containing deleted parts of the LTR region linked to a reporter gene showed that the NF-kappaB binding site was essential for HIV-1 LTR activity in CD40-stimulated B lymphocytes.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	parts	part	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3538
# text = In addition, electrophoretic mobility shift and supershift assays revealed that important NF-kappaB binding activity composed of at least p50, p65, and c-Rel NF-kappaB subunits was present in nuclei of CD40-stimulated B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
5	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
6	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
9	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	at	at	ADV	RB	_	_	_	_	_
21	least	least	ADV	RBS	Degree=Sup	_	_	_	_
22	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	present	present	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3539
# text = These results confirm at a molecular level the ability of HIV-1 to replicate in B cells and that this activity is strongly associated with NF-kappaB.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	strongly	strongly	ADV	RB	_	_	_	_	_
25	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3540
# text = Document 003003493 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003493	003003493	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3541
# text = Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes.
1	Oxidative	Oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
2	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
3	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
4	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3542
# text = Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury.
1	Oxidizing	Oxidizing	ADJ	JJ	Degree=Pos	_	_	_	_
2	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
5	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
21	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3543
# text = In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	evidence	evidence	SCONJ	IN	_	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
26	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	_
27	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	previously	previously	ADV	RB	_	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3544
# text = H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2.
1	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	strongly	strongly	ADV	RB	_	_	_	_	_
36	synergize	synergize	VERB	VB	VerbForm=Inf	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3545
# text = Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	anti-STAT3	anti-STAT3	NUM	CD	NumType=Card	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	precipitated	precipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	92	92	NUM	CD	NumType=Card	_	_	_	_
11	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	upon	upon	ADP	IN	_	_	_	_	_
18	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3546
# text = Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation.
1	Phenylarsine	Phenylarsine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	oxide	oxide	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
7	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	genistein	genistein	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	cooperated	cooperate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cancelled	cancell	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3547
# text = Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	presented	present	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	Fe2+/Cu2	Fe2+/Cu2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	ions	ion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	that.OH	that.Oh	PROPN	NNP	Number=Sing	_	_	_	_
12	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	H2O2	H2O2	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	Fenton	Fenton	PROPN	NNP	Number=Sing	_	_	_	_
17	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
22	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
23	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
24	species	species	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	directly	directly	ADV	RB	_	_	_	_	_
27	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
28	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3548
# text = Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus.
1	Present	present	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	s	s	X	AFX	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
25	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	hence	hence	ADV	RB	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3549
# text = These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	oxidizing	oxidize	VERB	VBG	VerbForm=Ger	_	_	_	_
16	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	framework	framework	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
27	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	JAK	JAK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	_
33	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3550
# text = Document 003003494 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003494	003003494	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3551
# text = 20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor.
1	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Epi	Epi	NOUN	NN	Number=Sing	_	_	_	_
4	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
9	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	highly	highly	ADV	RB	_	_	_	_	_
12	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
13	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	DRIP	drip	NOUN	NN	Number=Sing	_	_	_	_
16	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
22	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3552
# text = 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays a major role in the stimulation of bone growth, mineralization, and intestinal calcium and phosphate absorption; it also acts as a general inhibitor of cellular proliferation.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Dihydroxyvitamin	Dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
4	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	mineralization	mineralization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
27	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
30	absorption	absorption	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
33	also	also	ADV	RB	_	_	_	_	_
34	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
38	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
41	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3553
# text = Several new, clinically relevant compounds dissociate antiproliferative and calcemic activities of 1,25(OH)2D3, but the molecular basis for this has not been clearly elucidated.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	clinically	clinically	ADV	RB	_	_	_	_	_
5	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
6	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
7	dissociate	dissociate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	calcemic	calcemic	ADJ	JJ	Degree=Pos	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	clearly	clearly	ADV	RB	_	_	_	_	_
29	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3554
# text = Here, we tested whether the potency of one class of compounds, 20-epi analogues, to induce myeloid cell differentiation, is because of direct molecular effects on vitamin D receptor (VDR).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	one	one	NUM	CD	NumType=Card	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	epi	epi	NOUN	NN	Number=Sing	_	_	_	_
17	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	because	because	ADP	IN	_	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
29	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
30	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
33	D	d	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3555
# text = We report that two 20-epi analogues, MC1627 and MC1288, induced differentiation and transcription of p21(Waf1,Cip1), a key VDR target gene involved in growth inhibition, at a concentration 100-fold lower than that of 1,25(OH)2D3.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	epi	epi	NOUN	NN	Number=Sing	_	_	_	_
8	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	MC	Mc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	1627	1627	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	MC1288	MC1288	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Waf1	Waf1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
24	Cip1	Cip1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
29	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
30	target	target	NOUN	NN	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
35	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
40	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
42	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
44	than	than	ADP	IN	_	_	_	_	_
45	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3556
# text = We compared this sensitivity to analogue effects on VDR interacting proteins: RXR, GRIP-1, and DRIP205, a subunit of the DRIP coactivator complex.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	analogue	analogue	VERB	VB	VerbForm=Inf	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
10	interacting	interacting	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	GRIP	grip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	DRIP205	DRIP205	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	DRIP	drip	PROPN	NNP	Number=Sing	_	_	_	_
27	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3557
# text = Compared with the interaction of VDR with RXR or GRIP-1, the differentiation dose-response most closely correlated to the ligand-dependent recruitment of the DRIP coactivator complex to VDR and to the ability of the receptor to activate transcription in a cell-free system.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	GRIP	grip	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	most	most	ADV	RBS	_	_	_	_	_
20	closely	closely	ADV	RB	_	_	_	_	_
21	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DRIP	drip	PROPN	NNP	Number=Sing	_	_	_	_
31	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
32	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
50	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3558
# text = These results provide compelling links between the efficiency of the 20-epi analogue in inducing VDR/DRIP interactions, transactivation in vitro, and its enhanced ability to induce cellular differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	compelling	compelling	ADJ	JJ	Degree=Pos	_	_	_	_
5	links	link	NOUN	NNS	Number=Plur	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	epi	epi	NOUN	NN	Number=Sing	_	_	_	_
14	analogue	analogue	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	DRIP	drip	NOUN	NN	Number=Sing	_	_	_	_
20	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
28	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
33	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3559
# text = Document 003003495 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003495	003003495	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3560
# text = Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	HBsAg	HBsAg	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HBxAg	HBxAg	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3561
# text = The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
3	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
6	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
7	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
14	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
20	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3562
# text = This study was initiated to investigate whether a cytokine imbalance oriented toward Th2 type response plays a role in chronic hepatitis B. Cytokine profiles of peripheral blood mononuclear cells associated with chronic hepatitis
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	_
11	oriented	orient	ADJ	JJ	Degree=Pos	_	_	_	_
12	toward	toward	ADP	IN	_	_	_	_	_
13	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
21	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
22	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
23	Cytokine	Cytokine	PROPN	NNP	Number=Sing	_	_	_	_
24	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
27	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
28	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	chronic	chronic	NOUN	NN	Number=Sing	_	_	_	_
33	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3563
# text = B were analysed by RT-PCR.
1	B	benefit	NOUN	NN	Number=Sing	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3564
# text = Upon HBsAg stimulation, expression of IFN-gamma, IL-2, IL-4, and IL-10 was detected in 41%, 8%, 41%, and 50% of the patients, respectively.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	HBsAg	HBsAg	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	10	10	NUM	CD	NumType=Card	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	41	41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	41	41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	%	%	SYM	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3565
# text = Among these cytokines, the expression of IFN-gamma was associated with high levels of serum AST/ALT.
1	Among	among	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
18	AST	AST	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	ALT	ALT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3566
# text = However, we could not prove that Th2 type cytokines had a protective effect on hepatocytes.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protective	protective	ADJ	JJ	Degree=Pos	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	hepatocytes	hepatocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3567
# text = Upon HBxAg stimulation, there was no recognizable association of cytokine patterns with AST/ALT levels.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	HBxAg	HBxAg	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	there	there	PRON	EX	_	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	recognizable	recognizable	ADJ	JJ	Degree=Pos	_	_	_	_
9	association	association	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	AST	Ast	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	ALT	al	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3568
# text = In conclusion, production of a Th1 cytokine, IFN-gamma, by HBsAg-reactive cells was associated with hepatocyte damage in chronic hepatitis B, while no counteracting effect of Th2 cytokines produced by those cells was observed.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	HBsAg	HBsAg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	hepatocyte	hepatocyte	NOUN	NN	Number=Sing	_	_	_	_
23	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
26	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	no	no	DET	DT	_	_	_	_	_
31	counteracting	counteract	NOUN	NN	Number=Sing	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
35	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
36	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3569
# text = Document 003003501 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003501	003003501	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3570
# text = Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	BLR2/EBI1	Blr2/ebi1	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3571
# text = In our attempt to identify chemokine receptors that are related to Burkitt's lymphoma receptor 1 (BLR1) and are expressed in activated lymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a seven transmembrane receptor termed BLR2.
1	In	in	ADP	IN	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	attempt	attempt	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
6	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	's	's	PART	POS	_	_	_	_	_
14	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	BLR1	Blr1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
27	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
38	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	seven	seven	NUM	CD	NumType=Card	_	_	_	_
41	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	BLR2	Blr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3572
# text = The protein shows significant sequence similarities to the family of G-protein coupled chemokine receptors and turned out to be identical to the recently described receptor EBI1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	coupled	coupl	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	turned	turn	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	out	out	ADP	RP	_	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	recently	recently	ADV	RB	_	_	_	_	_
25	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	EBI1	Ebi1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3573
# text = Northern blot analysis revealed that BLR2 mRNA could be highly stimulated in mitogen- and anti-CD3-treated peripheral blood lymphocytes.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	BLR2	Blr2	NUM	CD	NumType=Card	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	highly	highly	ADV	RB	_	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3574
# text = BLR2-specific mRNA could be detected in all Epstein-Barr virus positive B cell lines.
1	BLR2	Blr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3575
# text = We show that transcription of the BLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2, a key regulator of viral and cellular genes in immortalized B cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	BLR2	Blr2	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	specifically	specifically	ADV	RB	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
19	BL	BL	PROPN	NNP	Number=Sing	_	_	_	_
20	41	41	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	estrogen	estrogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-mediated	-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
37	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
42	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	immortalized	immortalized	ADJ	JJ	Degree=Pos	_	_	_	_
45	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3576
# text = Our data suggest an involvement of BLR2 in the regulation of migration in activated lymphocytes and in viral pathogenesis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	BLR2	BLR2	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3577
# text = Document 003003502 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003502	003003502	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3578
# text = Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
6	footprinted	footprint	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3579
# text = Erythroid lineage and developmental stage specificities.
1	Erythroid	Erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
2	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
5	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
6	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3580
# text = Transcriptional regulation of the human alpha-like globin genes, embryonic zeta 2 and adult alpha, during erythroid development is mediated by a distal enhancer, HS-40.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
13	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	development	development	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	HS	HS	ADV	RB	_	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3581
# text = Previous protein-DNA binding studies have shown that HS-40 consists of multiple nuclear factor binding motifs that are occupied in vivo in an erythroid lineage- and developmental stage-specific manner.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	HS	HS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	40	40	NUM	CD	NumType=Card	_	_	_	_
13	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
28	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
32	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3582
# text = We have systematically analyzed the functional roles of these factor binding motifs of HS-40 by site-directed mutagenesis and transient expression assay in erythroid cell cultures.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	systematically	systematically	ADV	RB	_	_	_	_	_
4	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	40	40	NUM	CD	NumType=Card	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3583
# text = Three of these HS-40 enhancer motifs, 5'NF-E2/AP1, GT II, and GATA-1(c), positively regulate the zeta 2-globin promoter activity in embryonic/fetal erythroid K562 cells and the adult alpha-globin promoter activity in adult erythroid MEL cells.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	HS	H	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	40	40	NUM	CD	NumType=Card	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	5'NF-	5'NF-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	E2/AP1	E2/AP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	GT	GT	PROPN	NNP	Number=Sing	_	_	_	_
14	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	positively	positively	ADV	RB	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	K562	k562	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
43	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
50	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
51	MEL	Mel	NOUN	NN	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3584
# text = On the other hand, the 3'NF-E2/AP1 motif is able to exert both positive and negative regulatory effects on the zeta 2-globin promoter activity in K562 cells, and this dual function appears to be modulated through differential binding of the ubiquitous AP1 factors and the erythroid-enriched NF-E2 factor.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	3'NF	3'nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	K562	K562	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
38	function	function	NOUN	NN	Number=Sing	_	_	_	_
39	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
42	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	through	through	ADP	IN	_	_	_	_	_
44	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
45	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
49	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	_
50	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	E2	e2	NUM	CD	NumType=Card	_	_	_	_
59	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3585
# text = Mutation in the GATA-1(d) motif, which exhibits an adult erythroid-specific genomic footprint, decreases the HS-40 enhancer function in dimethyl sulfoxide-induced MEL cells but not in K562 cells.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	d	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	exhibits	exhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
16	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
20	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	HS	HS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	40	40	NUM	CD	NumType=Card	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	dimethyl	dimethyl	ADJ	JJ	Degree=Pos	_	_	_	_
31	sulfoxide	sulfoxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	MEL	MEL	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	K562	K562	NUM	CD	NumType=Card	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3586
# text = These studies have defined the regulatory roles of the different HS-40 motifs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	HS	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	40	40	NUM	CD	NumType=Card	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3587
# text = The remarkable correlation between genomic footprinting data and the mutagenesis results also suggests that the erythroid lineage- and developmental stage-specific regulation of human alpha-like globin promoters is indeed modulated by stable binding of specific nuclear factors in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	remarkable	remarkable	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
7	data	data	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mutagenesis	mutagenesis	ADJ	JJ	Degree=Pos	_	_	_	_
11	results	result	NOUN	NNS	Number=Plur	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
21	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	indeed	indeed	ADV	RB	_	_	_	_	_
34	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
37	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
41	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3588
# text = Document 003003503 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003503	003003503	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3589
# text = Expression of c-fos, c-jun and jun B in peripheral blood lymphocytes from young and elderly adults.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
19	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3590
# text = The expression of c-fos, c-jun and jun B proto-oncogenes was studied in phytohemagglutinin (PHA) activated peripheral blood lymphocytes (PBL) from young and aged humans.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
23	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PBL	PBL	INTJ	UH	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	aged	aged	ADJ	JJ	Degree=Pos	_	_	_	_
32	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3591
# text = Specific mRNAs for c-fos and c-jun were detectable within 30 min after cell activation and reached maximal levels within 2 h.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	30	30	NUM	CD	NumType=Card	_	_	_	_
14	min	min	NOUN	NNS	Number=Plur	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	within	within	ADP	IN	_	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3592
# text = Both c-fos and jun B mRNAs decreased to pre-activation levels within 6 h, while c-jun mRNA remained elevated.
1	Both	both	DET	DT	_	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	mRNAs	mRNA	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	pre-activation	pre-activation	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
19	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
20	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3593
# text = In PHA-activated PBL, no age-related differences were observed in c-fos or jun B mRNA expression.
1	In	in	ADP	IN	_	_	_	_	_
2	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
11	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	jun	jun	VERB	VB	VerbForm=Inf	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3594
# text = However, c-jun mRNA levels decreased significantly (1.73 +/- 0.08 vs. 1.16 +/- 0.09 arbitrary units, P < 0.01, young vs. old) in PBL from elderly individuals activated with PHA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	1.73	1.73	NUM	CD	NumType=Card	_	_	_	_
11	+/-	+/-	SYM	SYM	_	_	_	_	_
12	0.08	0.08	NUM	CD	NumType=Card	_	_	_	_
13	vs.	versus	ADP	IN	_	_	_	_	_
14	1.16	1.16	NUM	CD	NumType=Card	_	_	_	_
15	+/-	+/-	SYM	SYM	_	_	_	_	_
16	0.09	0.09	NUM	CD	NumType=Card	_	_	_	_
17	arbitrary	arbitrary	ADJ	JJ	Degree=Pos	_	_	_	_
18	units	unit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	P	P	PROPN	NNP	Number=Sing	_	_	_	_
21	<	<	PUNCT	-LRB-	_	_	_	_	_
22	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
25	vs.	vs.	CCONJ	CC	_	_	_	_	_
26	old	old	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
32	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
33	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	PHA	PHa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3595
# text = Because previous work has demonstrated that T cells from elderly individuals may display normal proliferative responses when activated via the anti-CD2 pathway, c-jun and jun B mRNA expression was also studied in anti-CD2-activated purified T cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
11	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	display	display	VERB	VB	VerbForm=Inf	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
16	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
17	when	when	ADV	WRB	PronType=Int	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	anti-CD2	anti-cd2	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-activated	-activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3596
# text = No age-related differences were found in the expression of either of these two proto-oncogenes by anti-CD2 activated T cells.
1	No	no	DET	DT	_	_	_	_	_
2	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	either	either	DET	DT	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
20	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	T	t	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3597
# text = These results suggest that the decreased IL-2 production and proliferative response displayed by PHA-activated PBL from elderly adults may be related to age-related changes in c-jun mRNA expression and in the ratio of c-fos to c-jun mRNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
22	adults	adult	NOUN	NNS	Number=Plur	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
34	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
46	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
47	mRNA.	mRNA.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3598
# text = Document 003003506 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003506	003003506	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3599
# text = Lineage-specific activation of STAT3 by interferon-gamma in human neutrophils.
1	Lineage	Lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	interferon	interferon	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3600
# text = Binding of interferon-gamma (IFN-gamma) to its heterodimeric receptor induces activation of the tyrosine kinases JAK1 and JAK2 followed by tyrosine phosphorylation of STAT1alpha.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
21	JAK1	JAK1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	JAK2	JAK2	NUM	CD	NumType=Card	_	_	_	_
24	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3601
# text = Selective activation of STAT1alpha at the IFN-gamma receptor is achieved by specific interaction between a cytosolic tyrosine motif including Y440 in the IFN-gamma receptor alpha-chain and the SH2 domain of STAT1alpha.
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	motif	motif	SCONJ	IN	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	Y440	Y440	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
35	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3602
# text = We demonstrate that, in addition to STAT1alpha, STAT3 is also activated by IFN-gamma in human neutrophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3603
# text = The activation of STAT3 was not found in human eosinophils, monocytes, and HL-60 cells, although the STAT3 protein was expressed in these cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	HL	HL	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	60	60	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	although	although	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3604
# text = The cell type-specific activation of STAT3 by IFN-gamma was also observed in neutrophils that are differentiated in vitro from human CD34+ hematopoietic stem cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
28	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3605
# text = These results indicate that a single cytokine receptor can activate different
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3606
# text = STAT family members in a cell-specific manner, which might result in cell-specific gene transcription.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	members	member	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3607
# text = Document 003003508 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003508	003003508	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3608
# text = Identification and purification of human Stat proteins activated in response to interleukin-2.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	purification	purification	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3609
# text = A key cytokine induced during the immune response is IL-2.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3610
# text = Following T cell activation, the genes encoding IL-2 and the various chains of its receptor are transcriptionally induced.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3611
# text = In turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	secreted	secret	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	serves	serf	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3612
# text = Several recent studies have implicated Jak kinases in the signaling pathway induced by IL-2.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3613
# text = Following this lead, we set out to identify transcription factors induced in response to IL-2.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	lead	lead	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	set	set	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	out	out	ADP	RP	_	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3614
# text = Human peripheral blood lymphocytes were observed to contain several IL-2-inducible DNA binding activities.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
9	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3615
# text = Similar activities were also observed in a transformed human lymphocyte line, termed YT.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	YT	YT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3616
# text = We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	principal	principal	NOUN	NN	Number=Sing	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	component	component	ADJ	JJ	Degree=Pos	_	_	_	_
17	bears	bear	NOUN	NNS	Number=Plur	_	_	_	_
18	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
19	relatedness	relatedness	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	prolactin-	prolactin-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	first	first	ADV	RB	_	_	_	_	_
27	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	sheep	sheep	ADJ	JJ	Degree=Pos	_	_	_	_
30	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
31	gland	gland	NOUN	NN	Number=Sing	_	_	_	_
32	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3617
# text = We hypothesize that activation of this protein, designated hStat5, helps govern the biological effects of IL-2 during the immune response.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesize	hypothesize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	hStat5	hstat5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	helps	help	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	govern	govern	ADJ	JJ	Degree=Pos	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3618
# text = Document 003003514 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003514	003003514	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3619
# text = Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
4	interferon	interferon	ADP	IN	_	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3620
# text = All-trans-retinoic acid (ATRA) is the drug of choice in the treatment of acute promyelocytic leukemia (APL).
1	All	all	DET	DT	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
6	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	choice	choice	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
20	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	APL	APL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3621
# text = ATRA induces both in vitro and in vivo differentiation of APL cells into mature granulocytes.
1	ATRA	Atra	PROPN	NNP	Number=Sing	_	_	_	_
2	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
15	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3622
# text = However, the molecular mechanisms involved in ATRA-dependent growth inhibition and cellular differentiation are not presently understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	presently	presently	ADV	RB	_	_	_	_	_
19	understood	understand	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3623
# text = The NB4 cell line, which is derived from the bone marrow of a patient with APL during relapse, can be used as a model system to study the growth and differentiation of APL cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
12	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	APL	Apl	NOUN	NNS	Number=Plur	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	relapse	relapse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	model	model	NOUN	NN	Number=Sing	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3624
# text = Because interferon (IFN) regulatory factors (IRF-1 and IRF-2) and other IFN-inducible gene products regulate cell growth, we analyzed the effects of ATRA on the expression of these genes.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	products	product	NOUN	NNS	Number=Plur	_	_	_	_
24	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
29	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
39	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3625
# text = We show that ATRA directly activates IRF-1 gene expression, followed by activation of IRF-2 and 2'-5' oligoadenylate synthetase (OAS) gene expression with slower kinetics.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
5	directly	directly	ADV	RB	_	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	'	'	PUNCT	``	_	_	_	_	_
26	oligoadenylate	oligoadenylate	ADJ	JJ	Degree=Pos	_	_	_	_
27	synthetase	synthetase	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	OAS	OAS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	slower	slower	NOUN	NN	Number=Sing	_	_	_	_
35	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3626
# text = In addition to NB4 cells, ATRA also activated IRF-1 gene expression in HL-60, U937, and THP-1 cells, which all respond to ATRA by growth inhibition.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	all	all	DET	DT	_	_	_	_	_
30	respond	respond	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
35	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3627
# text = A more than additive increase in IRF-1 gene expression was seen with ATRA and IFN-gamma in NB4 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
3	than	than	ADP	IN	_	_	_	_	_
4	additive	additive	ADJ	JJ	Degree=Pos	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3628
# text = ATRA did not activate nuclear factor kappa B or signal transducer and activator of transcription (STAT) activation pathways, suggesting that an alternate mechanism is involved in IRF-1 gene activation.
1	ATRA	ATRA	ADV	RB	_	_	_	_	_
2	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	alternate	alternate	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3629
# text = The ATRA-induced expression of IRF-1, an activator of transcription and repressor of transformation, may be one of the molecular mechanisms of ATRA-induced growth inhibition, and the basis for the synergistic actions of ATRA and IFNs in myeloid leukemia cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ATRA	ATRa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
40	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	ATRA	ATRa	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	IFNs	IFN	PROPN	NNP	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
47	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3630
# text = Document 003003516 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003516	003003516	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3631
# text = Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	RelB	Relb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	situ	situ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3632
# text = The Rel/NF-kappa B proteins, p50, p52, p65, c-Rel, and RelB, constitute a family of transcription factors involved in the positive regulation of a variety of genes during the immune response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Rel/	rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	RelB	RelB	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	constitute	constitute	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
38	during	during	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
41	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3633
# text = Recently, it has been shown that RelB knockout mice have no dendritic cells (DC).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
9	knockout	knockout	ADP	IN	_	_	_	_	_
10	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
11	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	no	no	DET	DT	_	_	_	_	_
13	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3634
# text = An overexpression of p50 has been described in follicular dendritic cells (FDC).
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
10	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3635
# text = A constitutive NF-kappa B activity has been reported in mature macrophages.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3636
# text = This led to the hypothesis that some of the Rel/NF-kappa B proteins were key nuclear factors in functions of accessory cells of the immune response.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	some	some	DET	DT	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3637
# text = Therefore, we investigated in situ the nuclear localization of Rel/NF-kappa B proteins in accessory cells of the immune system by immunohistochemistry and double labeling by immunofluorescence from five normal human tonsils and five lymph nodes with follicular hyperplasia.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	situ	situ	PRON	PRP	Case=Acc|Person=2|PronType=Prs	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	immunohistochemistry	immunohistochemistry	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	double	double	ADJ	JJ	Degree=Pos	_	_	_	_
29	labeling	labele	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	five	five	NUM	CD	NumType=Card	_	_	_	_
34	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	tonsils	tonsil	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	five	five	NUM	CD	NumType=Card	_	_	_	_
39	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
40	nodes	node	NOUN	NNS	Number=Plur	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
43	hyperplasia	hyperplasia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3638
# text = Nuclear p65 and c-Rel proteins were found in all cell types including lymphocytes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	types	type	NOUN	NNS	Number=Plur	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3639
# text = In germinal centers GC, p50, p52, and RelB were found in the nuclei of FDC only and were not detected in the nuclei of CD68+ cells.
1	In	in	ADP	IN	_	_	_	_	_
2	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
3	centers	center	NOUN	NNS	Number=Plur	_	_	_	_
4	GC	GC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	CD68	CD68	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3640
# text = In T cell areas, p50, p52, and RelB were found in the nuclei of HLA-DR+ cells with an antigen-presenting cell (APC) morphology.
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	areas	area	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	DR	dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	presenting	present	VERB	VBG	VerbForm=Ger	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	APC	APC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3641
# text = p52 and RelB were detected in the nuclei in both CD1a+ and CD68+ cells from the T cell area, whereas p50 was found only in CD68- and CD1a- cells.
1	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	CD1a	CD1a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	CD68	CD68	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	area	area	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	CD68	CD68	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	CD1a	CD1a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3642
# text = Cells with nuclear p50 were negative for the CD38, CD20 and CD2 markers.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD38	Cd38	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CD20	CD20	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
14	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3643
# text = These results show that, physiologically, high levels of nuclear of p50, p52 and RelB are restricted to accessory cells of the immune system, which include FDC in GC, and DC and macrophages in the T cell zone, that specialized scavenger macrophages from GC do not have detectable levels of p52 and RelB, whereas macrophages from the T cell area, known to present the antigen to T cells, do have both nuclear p52 and RelB, and that in the T cell zone, p52 and RelB are located in nuclei of both CD1a+, CD68+ or both, cells APC, whereas p50 is restricted to CD1a- and CD68- APC.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	physiologically	physiologically	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	accessory	accessory	VERB	VB	VerbForm=Inf	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
26	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	T	T	PROPN	NNP	Number=Sing	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	zone	zone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	specialized	specialized	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
47	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
48	from	from	ADP	IN	_	_	_	_	_
49	GC	GC	PROPN	NNPS	Number=Plur	_	_	_	_
50	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
51	not	not	PART	RB	_	_	_	_	_
52	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
53	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
54	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	whereas	whereas	SCONJ	IN	_	_	_	_	_
61	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
62	from	from	ADP	IN	_	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	T	T	PROPN	NNP	Number=Sing	_	_	_	_
65	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
66	area	area	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	known	known	ADJ	JJ	Degree=Pos	_	_	_	_
69	to	to	PART	TO	_	_	_	_	_
70	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
71	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
72	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
73	to	to	PART	TO	_	_	_	_	_
74	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
75	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
76	,	,	PUNCT	,	_	_	_	_	_
77	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
78	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
79	both	both	DET	DT	_	_	_	_	_
80	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
81	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
82	and	and	CCONJ	CC	_	_	_	_	_
83	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
84	,	,	PUNCT	,	_	_	_	_	_
85	and	and	CCONJ	CC	_	_	_	_	_
86	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
87	in	in	ADP	IN	_	_	_	_	_
88	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
89	T	T	PROPN	NNP	Number=Sing	_	_	_	_
90	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
91	zone	zone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
92	,	,	PUNCT	,	_	_	_	_	_
93	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
94	and	and	CCONJ	CC	_	_	_	_	_
95	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
96	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
97	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
98	in	in	ADP	IN	_	_	_	_	_
99	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
100	of	of	ADP	IN	_	_	_	_	_
101	both	both	DET	DT	_	_	_	_	_
102	CD1a	CD1a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
103	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
104	,	,	PUNCT	,	_	_	_	_	_
105	CD68	CD68	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
106	+	+	SYM	SYM	_	_	_	_	_
107	or	or	CCONJ	CC	_	_	_	_	_
108	both	both	DET	DT	_	_	_	_	SpaceAfter=No
109	,	,	PUNCT	,	_	_	_	_	_
110	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
111	APC	Apc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
112	,	,	PUNCT	,	_	_	_	_	_
113	whereas	whereas	SCONJ	IN	_	_	_	_	_
114	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
115	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
116	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
117	to	to	ADP	IN	_	_	_	_	_
118	CD1a	CD1a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
119	-	-	PUNCT	,	_	_	_	_	_
120	and	and	CCONJ	CC	_	_	_	_	_
121	CD68	CD68	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
122	-	-	PUNCT	HYPH	_	_	_	_	_
123	APC	APC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
124	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3644
# text = The different patterns of p50, p52 and RelB protein nuclear localization may provide insight into their different roles during the immune response in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	p52	p52	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	RelB	Relb	PROPN	NNP	Number=Sing	_	_	_	_
10	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
15	insight	insight	ADV	RB	_	_	_	_	_
16	into	into	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3645
# text = Document 003003523 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003523	003003523	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3646
# text = Glucocorticoid-mediated inhibition of interleukin-2 receptor alpha and -beta subunit expression by human T cells.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3647
# text = To determine the mechanism of glucocorticoid (GC)-mediated inhibition of T cell functions, the effect of dexamethasone (DM) on T cell proliferation and interleukin-2 receptor (IL-2R) generation were studied.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	DM	DM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	R	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3648
# text = Dexamethasone inhibited IL-2-induced T cell proliferation by 30%-88%, relative to its concentration within the cultures.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	30%	30%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	88	88	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	relative	relative	ADV	RB	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3649
# text = The effect of DM on expression of IL-2R alpha (Tac, p55, CD25) and beta (p75) genes in activated T cells was examined next.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DM	DM	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Tac	Tac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	p55	p55	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	CD25	CD25	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	p75	p75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	next	next	ADV	RB	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3650
# text = In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p < 0.01).
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
21	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	DM	Dm	PROPN	NNP	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
33	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	%	%	SYM	NN	Number=Sing	_	_	_	_
38	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
43	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	%	%	SYM	NN	Number=Sing	_	_	_	_
48	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
53	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
54	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
55	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
56	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	to	to	ADP	IN	_	_	_	_	_
58	T	t	PROPN	NNP	Number=Sing	_	_	_	_
59	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
60	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
61	in	in	ADP	IN	_	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	DM	DM	PROPN	NNP	Number=Sing	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	p	p	NOUN	NN	Number=Sing	_	_	_	_
68	<	<	PUNCT	-LRB-	_	_	_	_	_
69	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3651
# text = Inhibition of membrane IL-2R alpha and IL-2R beta expression by 10(-6)
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 3652
# text = M DM was partially reversible by recombinant human IL-2 (rhIL-2).
1	M	m	NOUN	NN	Number=Sing	_	_	_	_
2	DM	Dm	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	partially	partially	ADV	RB	_	_	_	_	_
5	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	rhIL	rhil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3653
# text = By Northern blot analysis, DM caused a comparable decrease in IL-2R alpha and in IL-2R beta mRNA levels to membrane receptor expression in mitogen-stimulated T cells.
1	By	by	ADP	IN	_	_	_	_	_
2	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
3	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	DM	DM	PROPN	NNP	Number=Sing	_	_	_	_
7	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
10	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
21	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
22	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	membrane	membrane	VERB	VB	VerbForm=Inf	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3654
# text = By in vitro transcription assays, DM regulated IL-2R alpha gene expression at a transcriptional level while transcription of IL-2R beta gene was unaffected by DM.
1	By	by	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	DM	Dm	PROPN	NNP	Number=Sing	_	_	_	_
8	regulated	regulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	R	r	X	GW	_	_	_	_	_
13	alpha	alpha	X	GW	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	while	while	SCONJ	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	DM	DM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3655
# text = The mechanism of action of DM on IL-2R alpha transcription was examined by determining the mRNA levels of the p50 subunit of nuclear factor kappa B (NF-kappa B), a transcription factor that stimulates IL-2R alpha gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	DM	DM	PROPN	NNP	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	that	that	PRON	WDT	PronType=Rel	_	_	_	_
40	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	X	LS	_	_	_	_	SpaceAfter=No
44	R	r	X	GW	_	_	_	_	_
45	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
46	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3656
# text = The data indicate that 10(-6) M DM increased T cell p50 NF-kappa B mRNA levels by four-fold compared to the levels obtained in the absence of DM.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	M	m	NOUN	NN	Number=Sing	_	_	_	_
10	DM	Dm	NOUN	NN	Number=Sing	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	four	four	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	DM	DM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3657
# text = Further, the level of nuclear proteins capable of binding to the NF-kappa B sites in activated T cells increased in response to DM.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	level	level	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	DM	DM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3658
# text = In sum, DM regulates T cell membrane expression of IL-2R by more than one molecular mechanism.
1	In	in	ADP	IN	_	_	_	_	_
2	sum	sum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	DM	DM	PROPN	NNP	Number=Sing	_	_	_	_
5	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3659
# text = Document 003003528 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003528	003003528	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3660
# text = Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
7	nephritis	nephritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3661
# text = We investigated the clinical significance of glucocorticoid receptor determination in 20 patients with systemic lupus erythematosus (SLE) who afterwards developed nephrotic syndrome.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
5	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	20	20	NUM	CD	NumType=Card	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
16	erythematosus	erythematosus	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	SLE	SLE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	who	who	PRON	WP	PronType=Rel	_	_	_	_
21	afterwards	afterwards	ADV	RB	_	_	_	_	_
22	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	nephrotic	nephrotic	ADJ	JJ	Degree=Pos	_	_	_	_
24	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3662
# text = Glucocorticoid receptor concentrations in mononuclear leukocytes (MNL) in these patients were comparable with those in both other patients with SLE and healthy persons.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	SLE	Sle	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
25	persons	person	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3663
# text = Improvement in urinary protein excretion and in disease activity, which was scored according to the SLE Disease Activity Index system of the University of Toronto, closely related to the glucocorticoid receptor concentrations in MNL isolated from the corresponding patients.
1	Improvement	improvement	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	excretion	excretion	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	scored	score	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	according	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	SLE	SLE	PROPN	NNP	Number=Sing	_	_	_	_
18	Disease	disease	NOUN	NN	Number=Sing	_	_	_	_
19	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	Index	index	NOUN	NN	Number=Sing	_	_	_	_
21	system	system	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	University	University	PROPN	NNP	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Toronto	Toronto	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	closely	closely	ADV	RB	_	_	_	_	_
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	_
37	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
41	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3664
# text = In summary, glucocorticoid receptor determination in patients with lupus nephritis may be a predictive clue for assessing responsiveness to glucocorticoid therapy.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
11	nephritis	nephritis	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	predictive	predictive	ADJ	JJ	Degree=Pos	_	_	_	_
16	clue	clue	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	SCONJ	IN	_	_	_	_	_
18	assessing	assess	VERB	VBG	VerbForm=Ger	_	_	_	_
19	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	_
22	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3665
# text = Document 003003533 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003533	003003533	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3666
# text = rel
1	rel	rel	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3667
# text = Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils.
1	Is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	rapidly	rapidly	ADV	RB	_	_	_	_	_
3	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
7	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
10	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3668
# text = Stimulation of neutrophils with granulocyte-colony stimulating factor (G-CSF) results in an enhanced respiratory burst, prolonged survival, and increased tumor cell killing.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
8	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
19	burst	burst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	killing	killing	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3669
# text = The effects of G-CSF are mediated by binding to specific, high affinity receptors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
14	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3670
# text = G-CSF receptors lack intrinsic tyrosine kinase activity, but activation of the receptor results in the rapid induction of tyrosine kinase activity.
1	G-	G-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3671
# text = Antiphosphotyrosine immunoblots of whole cell lysates prepared from neutrophils show that the G-CSF rapidly induces prominent tyrosine phosphorylation of a protein of a relative molecular mass of 80 kDa.
1	Antiphosphotyrosine	Antiphosphotyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunoblots	immunoblot	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
10	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	rapidly	rapidly	ADV	RB	_	_	_	_	_
16	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	relative	relative	ADV	RB	_	_	_	_	_
26	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
27	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	80	80	NUM	CD	NumType=Card	_	_	_	_
30	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3672
# text = Using monospecific antibodies, the 80-kDa tyrosine-phosphorylated protein has been shown to be p80c-rel, a proto-oncogene belonging to a family of transcriptional regulators which include NF-kB.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	monospecific	monospecific	ADJ	JJ	Degree=Pos	_	_	_	_
3	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
25	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3673
# text = The induction of tyrosine phosphorylation of p80c-rel was unique to G-CSF in that granulocyte-macrophage colony stimulating factor which also stimulates neutrophils and induces tyrosine phosphorylation does not result in tyrosine phosphorylation of p80c-rel.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	G-	G-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
21	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
29	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3674
# text = The consequences of p80c-rel tyrosine phosphorylation are not yet known; however, tyrosine-phosphorylated p80c-rel is capable of binding to DNA, and G-CSF stimulation results in an increase in the amount of p80c-rel which binds to DNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	yet	yet	ADV	RB	_	_	_	_	_
12	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
24	of	of	SCONJ	IN	_	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
32	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
33	results	result	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
44	which	which	PRON	WDT	PronType=Rel	_	_	_	_
45	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3675
# text = These results demonstrate that one of the first biochemical events which occurs in neutrophils following G-CSF stimulation, activation of a tyrosine kinase, leads directly to the tyrosine phosphorylation of p80c-rel.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
10	events	event	NOUN	NNS	Number=Plur	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	G-	G-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	directly	directly	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
31	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3676
# text = Thus, the tyrosine kinase activated by G-CSF appears to directly transduce a signal to a protein which functions as a transcriptional regulator.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	directly	directly	ADV	RB	_	_	_	_	_
14	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3677
# text = Document 003003538 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003538	003003538	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3678
# text = Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	relies	rely	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3679
# text = We have investigated mechanisms and consequences of STAT5 activation through the human IL-4 receptor (IL-4R).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	consequences	consequences	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4R	4r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3680
# text = By functionally expressing receptor mutants in the murine pro-B cell line Ba/F3, we could show that phosphorylated tyrosine residues within the IL-4R alpha chain are dispensable for IL-4-induced STAT5 activity.
1	By	by	ADP	IN	_	_	_	_	_
2	functionally	functionally	ADV	RB	_	_	_	_	_
3	expressing	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
9	pro-B	pro-b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	Ba/F3	Ba/F3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4R	4r	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3681
# text = However, disruption of a membrane-proximal proline-rich sequence motif ('box1') in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
9	proline	proline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
16	box1	box1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	either	either	DET	DT	_	_	_	_	_
21	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	bipartite	bipartite	ADJ	JJ	Degree=Pos	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4R	4R	PROPN	NNP	Number=Sing	_	_	_	_
28	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	ligand	ligand	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
35	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
38	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
39	JAK1	JAK1	NUM	CD	NumType=Card	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	but	but	CCONJ	CC	_	_	_	_	_
44	also	also	ADV	RB	_	_	_	_	_
45	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
55	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
56	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3682
# text = A dominant-negative version of STAT5b, but not of STAT5a, interfered with IL-4-induced DNA synthesis in Ba/F3 cells, suggesting an involvement of STAT5b in the control of cell proliferation through IL-4R.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	version	version	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT5a	STAT5a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	interfered	interfer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Ba/F3	Ba/F3	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	b	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	control	control	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
40	through	through	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	4R	4R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3683
# text = Reporter gene experiments finally showed that transcription from promoters of STAT5 target genes can be specifically induced by challenging cells with IL-4, and that both STAT5a and STAT5b can contribute to IL-4-triggered transcriptional control.
1	Reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	finally	finally	ADV	RB	_	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
12	target	target	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	specifically	specifically	ADV	RB	_	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	challenging	challenging	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	STAT5	STAT5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	a	a	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	STAT5	stat5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	b	b	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3684
# text = Document 003003539 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003539	003003539	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3685
# text = HTLV-1 Tax induces expression of various immediate early serum responsive genes.
1	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3686
# text = Human T-cell leukemia virus type 1 (HTLV-1) is an etiological agent of adult T-cell leukemia (ATL).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	etiological	etiological	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3687
# text = We showed here by mobility-shift assay that T-cell lines transformed with the virus contained high levels of AP-1 activities.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
8	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3688
# text = Consistent with this result, these cell lines expressed increased levels of mRNAs encoding the AP-1 proteins, c-Fos, Fra-1, c-Jun, JunB, and JunD.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	result	result	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	mRNAs	mRNA	SCONJ	IN	_	_	_	_	_
14	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Fra	Fra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3689
# text = Previously, transcription of the c-fos gene has been reported to be transactivated by the viral transcription factor, Tax1.
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	Tax1	Tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3690
# text = By using the human T-cell line (JPX-9), in which expression of the Tax1 is inducible, we showed that expression of mRNAs for Fra-1, c-Jun, and JunD was also transactivated by Tax1.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	JPX	JPX	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	which	which	DET	WDT	PronType=Int	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Tax1	tax1	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	Fra	Fra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	also	also	ADV	RB	_	_	_	_	_
41	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	Tax1	Tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3691
# text = Moreover, Tax1 activated expression of two other transcription factors having zinc finger motifs, Egr-1 and Egr-2, in the same cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tax1	Tax1	PROPN	NNP	Number=Sing	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
12	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
13	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3692
# text = The Tax1-inducible transcription factors identified here are encoded by the members of immediate early genes under the control of growth signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tax1	tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	here	here	ADV	RB	PronType=Dem	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	members	member	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
16	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	under	under	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3693
# text = Thus, Tax1 was suggested to replace growth signals, at least in part, by this mechanism.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tax1	Tax1	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	replace	replace	VERB	VB	VerbForm=Inf	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	at	at	ADV	RB	_	_	_	_	_
12	least	least	ADV	RBS	Degree=Sup	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3694
# text = Document 003003541 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003541	003003541	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3695
# text = Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?
1	Monoallelic	Monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Pax5	Pax5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	paradigm	paradigm	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	haploinsufficiency	haploinsufficiency	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
13	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	?	?	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3696
# text = It is generally assumed that most mammalian genes are transcribed from both alleles.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	generally	generally	ADV	RB	_	_	_	_	_
4	assumed	assume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
7	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3697
# text = Hence, the diploid state of the genome offers the advantage that a loss-of-function mutation in one allele can be compensated for by the remaining wild-type allele of the same gene.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	diploid	diploid	ADJ	JJ	Degree=Pos	_	_	_	_
5	state	state	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
9	offers	offer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	one	one	NUM	CD	NumType=Card	_	_	_	_
22	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	compensated	compensate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	remaining	remain	VERB	VBG	VerbForm=Ger	_	_	_	_
30	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3698
# text = Indeed, the vast majority of human disease syndromes and engineered mutations in the mouse genome are recessive, indicating that recessiveness is the 'default' state.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	vast	vast	ADJ	JJ	Degree=Pos	_	_	_	_
5	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
9	syndromes	syndrome	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	engineered	engineer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
16	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	recessive	recessive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	recessiveness	recessiveness	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
26	default	default	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	'	'	PUNCT	''	_	_	_	_	_
28	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3699
# text = However, a minority of genes are semi-dominant, as heterozygous loss-of-function mutation in these genes leads to phenotypic abnormalities.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	minority	minority	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	semi-dominant	semi-dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
12	loss	lose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	function	function	NOUN	NN	Number=Sing	_	_	_	_
17	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
24	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3700
# text = This condition, known as haploinsufficiency, has been described for five of the nine mammalian Pax genes, which are associated with mouse developmental mutants and human disease syndromes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	condition	condition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	haploinsufficiency	haploinsufficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	five	five	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nine	nine	NUM	CD	NumType=Card	_	_	_	_
16	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
17	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
26	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
30	syndromes	syndrome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3701
# text = Recently we have reported that the Pax5 gene is subject to allele-specific regulation during B cell development.
1	Recently	recently	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Pax5	pax5	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	allele	allele	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3702
# text = Pax5 is predominantly transcribed from only one of its two alleles in early B-lymphoid progenitors and mature B cells, while it transiently switches to a biallelic mode of transcription in pre-B and immature B cells.
1	Pax5	pax5	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	predominantly	predominantly	ADV	RB	_	_	_	_	_
4	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
17	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	while	while	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	transiently	transiently	ADV	RB	_	_	_	_	_
26	switches	switch	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	biallelic	biallelic	ADJ	JJ	Degree=Pos	_	_	_	_
30	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
35	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3703
# text = As a consequence, B-lymphoid tissues are mosaic with regard to the transcribed allele, and heterozygous mutation of Pax5 therefore results in deletion of B lymphocytes expressing only the mutant allele.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
8	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mosaic	mosaic	ADJ	JJ	Degree=Pos	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	regard	regard	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
20	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Pax5	pax5	PROPN	NNP	Number=Sing	_	_	_	_
23	therefore	therefore	ADV	RB	_	_	_	_	_
24	results	result	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
34	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3704
# text = The allele-specific regulation of Pax5 raises the intriguing possibility that monoallelic expression may also be the mechanism causing the haploinsufficiency of other Pax genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Pax5	Pax5	NUM	CD	NumType=Card	_	_	_	_
8	raises	rais	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	intriguing	intrigue	VERB	VBG	VerbForm=Ger	_	_	_	_
11	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
20	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	haploinsufficiency	haploinsufficiency	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3705
# text = In this review, we discuss different models accounting for the haploinsufficiency of mammalian Pax genes, provide further evidence in support of the allele-specific regulation of Pax5 and discuss the implication of these findings in the context of the recent literature describing the stochastic and monoallelic activation of other hematopoietic genes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	models	model	NOUN	NNS	Number=Plur	_	_	_	_
9	accounting	accounte	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	haploinsufficiency	haploinsufficiency	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
20	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	support	support	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	Pax5	Pax5	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	implication	implication	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	context	context	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
44	literature	literature	NOUN	NN	Number=Sing	_	_	_	_
45	describing	describe	VERB	VBG	VerbForm=Ger	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	stochastic	stochastic	ADJ	JJ	Degree=Pos	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
53	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
54	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3706
# text = Document 003003546 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003546	003003546	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3707
# text = [The effect of 24,25-dihydroxyvitamin D3 (dioxyvit) on Ca metabolism and immune status during chronic kidney failure]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	24,25	24,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
8	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	dioxyvit	dioxyvit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	Ca	ca	NOUN	NN	Number=Sing	_	_	_	_
14	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	status	status	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
20	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
21	failure	failure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3708
# text = Active metabolite of vitamin D3, 24R,25 (OH)2D3 (dioxyvit) was used at a daily dose of 100 micrograms in treatment of children affected with tubulointerstitial disease of kidney and with chronic glomerulonephritis under conditions of kidney insufficiency.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
5	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	24R,25	24R,25	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	dioxyvit	dioxyvit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	daily	daily	ADJ	JJ	Degree=Pos	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	100	100	NUM	CD	NumType=Card	_	_	_	_
23	micrograms	microgram	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	children	child	NOUN	NNS	Number=Plur	_	_	_	_
28	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	tubulointerstitial	tubulointerstitial	ADJ	JJ	Degree=Pos	_	_	_	_
31	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
37	glomerulonephritis	glomerulonephritis	NOUN	NN	Number=Sing	_	_	_	_
38	under	under	ADP	IN	_	_	_	_	_
39	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
42	insufficiency	insufficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3709
# text = The drug exhibited distinct normalizing effect on patterns of calcium metabolism: increase of total and ionized Ca2+ and of 25-OHD, decrease in concentration of parath hormone and osteocalcine in blood serum as well as on immunological parameters: restoration of decreased content of T- and 0-lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
3	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	normalizing	normalizing	NOUN	NN	Number=Sing	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
11	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	ionized	ionize	ADJ	JJ	Degree=Pos	_	_	_	_
18	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	OHD	Ohd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	parath	parath	NOUN	NN	Number=Sing	_	_	_	_
31	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	osteocalcine	osteocalcine	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
36	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
37	as	as	ADV	RB	_	_	_	_	_
38	well	well	ADV	RB	Degree=Pos	_	_	_	_
39	as	as	ADP	IN	_	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
42	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	:	:	PUNCT	:	_	_	_	_	_
44	restoration	restoration	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	content	content	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	0	0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3710
# text = Concentration of receptors of hormonal form of 1,25(OH)2D3 was found to be minimal in lymphocytes under conditions of chronic kidney insufficiency, while their expression, after the dioxyvit action, was detected only in patients with glomerulonephritis.
1	Concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	under	under	ADP	IN	_	_	_	_	_
21	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
24	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
25	insufficiency	insufficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	dioxyvit	dioxyvit	NOUN	NN	Number=Sing	_	_	_	_
34	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	only	only	ADV	RB	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	glomerulonephritis	glomerulonephritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3711
# text = Specific calcitropic effect of dioxyvit with simultaneous correction of vitamin D deficiency were apparently responsible for high efficacy of the drug in treatment of calcium metabolism and immunity impairments in children with renal deteriorations at the step of chronic kidney insufficiency.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	calcitropic	calcitropic	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	dioxyvit	dioxyvit	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
8	correction	correction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
11	D	would	NOUN	NN	Number=Sing	_	_	_	_
12	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	apparently	apparently	ADV	RB	_	_	_	_	_
15	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
18	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
26	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
29	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	children	child	NOUN	NNS	Number=Plur	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
34	deteriorations	deterioration	NOUN	NNS	Number=Plur	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	step	step	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
40	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
41	insufficiency	insufficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3712
# text = Document 003003547 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003547	003003547	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3713
# text = Detection of intracellular phosphorylated STAT-1 by flow cytometry.
1	Detection	detection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3714
# text = We have applied flow cytometry to the investigation of interferon-gamma activation of human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3715
# text = This approach uses monoclonal antibodies that distinguish between the native and phosphorylated forms of STAT-1.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
3	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	distinguish	distinguish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	native	native	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3716
# text = It enables rapid and quantitative assessment of STAT-1 phosphorylation on a discrete cell basis and is both more sensitive and less time consuming than immunoblotting.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	enables	enable	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
6	assessment	assessment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	both	both	ADV	RB	_	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	_
25	consuming	consume	VERB	VBG	VerbForm=Ger	_	_	_	_
26	than	than	SCONJ	IN	_	_	_	_	_
27	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3717
# text = Furthermore, it allows for discrimination between a mixture of cells that differ in their response to interferon-gamma.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	discrimination	discrimination	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	interferon	interferon	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3718
# text = This approach should allow for the evaluation of different intracellular signaling pathways using a combination of monoclonal reagents that are specific for native and activation modified proteins.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
3	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
4	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	evaluation	evaluation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
18	reagents	reagent	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	native	native	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3719
# text = Application of this form of testing should prove valuable in screening for signaling defects in selected patients with recurrent infections.
1	Application	application	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	form	form	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	testing	testing	NOUN	NN	Number=Sing	_	_	_	_
7	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
8	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
9	valuable	valuable	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	screening	screen	VERB	VBG	VerbForm=Ger	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
14	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	selected	selected	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	recurrent	recurrent	ADJ	JJ	Degree=Pos	_	_	_	_
20	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3720
# text = In addition, this technique should permit dissection of a full range of cellular signaling pathways at the protein level.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
6	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
7	permit	permit	VERB	VB	VerbForm=Inf	_	_	_	_
8	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
12	range	range	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3721
# text = Document 003003552 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003552	003003552	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3722
# text = Two glucocorticoid binding sites on the human glucocorticoid receptor.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3723
# text = Glucocorticoids are known to have a lytic effect in leukemic cells via interactions with the glucocorticoid receptor (GR).
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3724
# text = Cortisol and various synthetic glucocorticoids bind to the GR with one-site kinetics.
1	Cortisol	Cortisol	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
4	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
5	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
6	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3725
# text = Cortivazol (CVZ) is a unique, high potency synthetic glucocorticoid, which has a phenylpyrazol fused to the A-ring of the steroid nucleus and displays binding consistent with two or more sites in the cytosol from CEM C7 cells (a human acute lymphoblastic T-cell line).
1	Cortivazol	Cortivazol	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
10	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
11	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
12	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	phenylpyrazol	phenylpyrazol	NOUN	NN	Number=Sing	_	_	_	_
18	fused	fused	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
27	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	displays	display	NOUN	NNS	Number=Plur	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	two	two	NUM	CD	NumType=Card	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
42	C7	C7	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
47	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
48	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
49	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3726
# text = It has previously been shown that the lower affinity class of sites are similar in affinity and site molarity to those recognized by dexamethasone.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	molarity	molarity	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
22	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3727
# text = The higher affinity sites bind CVZ with 20- to 50-fold greater affinity, consistent with CVZ's enhanced biological effects.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
3	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	bind	bind	ADP	IN	_	_	_	_	_
6	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	fold	fold	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
14	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
15	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	consistent	consistent	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	's	's	PART	POS	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3728
# text = In mutant leukemic cells resistant to the lytic effects of dexamethasone, CVZ both lyses the cells and recognizes a single class of sites similar to the high affinity site in CEM C7 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	resistant	resistant	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	lyses	lysis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
29	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
33	C7	C7	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3729
# text = We have carried out experiments to define the nature of the higher affinity CVZ binding site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	out	out	ADP	RP	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
13	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
14	CVZ	CVZ	SCONJ	IN	Abbr=Yes	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3730
# text = We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line, IM-9; 2) the antiglucocorticoid RU 38486 is able to block both CVZ's higher and lower affinity sites; 3) all of CVZ's binding sites are on a protein immunologically indistinguishable from the human GR; and 4) freshly isolated clones of CVZ-resistant cells have lost all binding sites for CVZ.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	1	1	X	LS	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	CVZ	Cvz	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	IM	Im	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	;	;	PUNCT	,	_	_	_	_	_
30	2	2	X	LS	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	antiglucocorticoid	antiglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
34	RU	RU	PROPN	NNP	Number=Sing	_	_	_	_
35	38486	38486	NUM	CD	NumType=Card	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
40	both	both	CCONJ	CC	_	_	_	_	_
41	CVZ	Cvz	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	's	's	PART	POS	_	_	_	_	_
43	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
46	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
47	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	;	;	PUNCT	,	_	_	_	_	_
49	3	3	X	LS	_	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	all	all	DET	DT	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	's	's	PART	POS	_	_	_	_	_
55	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
56	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
57	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
58	on	on	ADP	IN	_	_	_	_	_
59	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
60	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
61	immunologically	immunologically	ADV	RB	_	_	_	_	_
62	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
63	from	from	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
66	GR	Gr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	;	;	PUNCT	,	_	_	_	_	_
68	and	and	CCONJ	CC	_	_	_	_	_
69	4	4	X	LS	_	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	_
71	freshly	freshly	ADV	RB	_	_	_	_	_
72	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
73	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
74	of	of	ADP	IN	_	_	_	_	_
75	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
76	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
77	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
78	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
79	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
80	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
81	all	all	DET	PDT	_	_	_	_	_
82	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
83	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
84	for	for	ADP	IN	_	_	_	_	_
85	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
86	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3731
# text = These data indicate that CVZ is recognizing two glucocorticoid binding sites on the human GR or a protein very similar to it.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	recognizing	recognize	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	very	very	ADV	RB	_	_	_	_	_
20	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3732
# text = Document 003003553 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003553	003003553	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3733
# text = Transcriptional activation of the macrophage colony-stimulating factor gene by IL-2 is associated with secretion of bioactive macrophage colony-stimulating factor protein by monocytes and involves activation of the transcription factor NF-kappa B. Human peripheral blood monocytes (Mo) constitutively display the beta-chain of the receptor for IL-2, whereas expression of the IL-2R alpha-chain is not constitutive but inducible with IL-2.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
6	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	bioactive	bioactive	ADJ	JJ	Degree=Pos	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	involves	involve	NOUN	NNS	Number=Plur	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
40	Human	Human	PROPN	NNP	Number=Sing	_	_	_	_
41	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
42	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
43	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	constitutively	constitutively	ADV	RB	_	_	_	_	_
48	display	display	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
56	for	for	ADP	IN	_	_	_	_	_
57	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	,	,	PUNCT	,	_	_	_	_	_
61	whereas	whereas	SCONJ	IN	_	_	_	_	_
62	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
68	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
71	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
72	not	not	PART	RB	_	_	_	_	_
73	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
74	but	but	CCONJ	CC	_	_	_	_	_
75	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
76	with	with	ADP	IN	_	_	_	_	_
77	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
78	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
79	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
80	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3734
# text = Here we report that binding of human IL-2 to its binding site leads to transcriptional activation of the macrophage CSF (M-CSF) gene in Mo resulting in accumulation of M-CSF mRNA and subsequent release of bioactive M-CSF protein as demonstrated by ELISA and inhibition of IL-2 induced release of an activity-stimulating growth of monocyte-type colonies by a neutralizing anti-M-CSF antibody.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
38	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
41	release	release	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	bioactive	bioactive	ADJ	JJ	Degree=Pos	_	_	_	_
44	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
47	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
48	as	as	SCONJ	IN	_	_	_	_	_
49	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	2	2	NUM	CD	NumType=Card	_	_	_	_
58	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	release	release	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
65	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	type	type	NOUN	NN	Number=Sing	_	_	_	_
70	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
71	by	by	ADP	IN	_	_	_	_	_
72	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
73	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
74	anti-M	anti-M	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
77	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3735
# text = Transcriptional activation of the M-CSF gene by IL-2 is preceded by enhanced binding activity of the transcription factor NF-kappa B to its recognition sequence in the 5' regulatory enhancer region of the M-CSF gene.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	'	's	PUNCT	``	_	_	_	_	_
35	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3736
# text = Moreover, using a heterologous promoter (herpes thymidine kinase) construct containing the NF-kappa B consensus sequence, it is shown that NF-kappa B binding by an IL-2-induced monocyte-derived nuclear protein confers reporter gene (human growth hormone) activity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	herpes	herpes	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	thymidine	thymidine	PRON	PRP	_	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
20	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
44	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
49	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3737
# text = Taken together, our findings indicate that IL-2 induces gene expression of M-CSF in human blood-derived Mo and provide evidence for involvement of NF-kappa B in transcriptional regulation of this gene.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	M-	m-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
25	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3738
# text = Document 003003557 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003557	003003557	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3739
# text = Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3740
# text = Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
14	transforms	transform	NOUN	NNS	Number=Plur	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3741
# text = STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells.
1	STAT	Stat	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3742
# text = We investigated the involvement of STATs in the transformation of T-cells by HTLV-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STATs	STATs	PROPN	NNPS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3743
# text = HTLV-1-transformed T-cell lines expressed higher amounts of STAT1, STAT3 and STAT5 RNA and proteins than virus-negative T cells.
1	HTLV	haHtlve	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
18	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	than	than	ADP	IN	_	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3744
# text = The expression of STAT1 and STAT5 in a human T-cell line was induced by Tax.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3745
# text = IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	then	then	ADV	RB	PronType=Dem	_	_	_	_
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3746
# text = In contrast, IL-2 did neither in a cell line lacking STAT3 and STAT5.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	neither	neither	VERB	VB	VerbForm=Inf	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
14	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3747
# text = The expression of STAT1, STAT3 and STAT5 mRNAs were also induced by a T-cell mitogen in normal human peripheral blood mononuclear cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
9	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3748
# text = Our results suggest that the induction of STAT1 and STAT5 by Tax enhances cytokine-induced functions of virus-infected T-cells, hence the induction may play a role in IL-2-dependent transformation steps of T-cells by HTLV-1.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
13	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	virus-infected	virus-infected	ADJ	JJ	Degree=Pos	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	hence	hence	ADV	RB	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
37	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3749
# text = Document 003003559 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003559	003003559	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3750
# text = A microtitre assay system for glucocorticoid receptors:
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	microtitre	microtitre	ADJ	JJ	Degree=Pos	_	_	_	_
3	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3751
# text = decreased receptor concentration in myocardial infarction.
1	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
6	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3752
# text = A major difficulty in determination of glucocorticoid receptor sites is the very complicated assay procedure.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	difficulty	difficulty	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	very	very	ADJ	JJ	Degree=Pos	_	_	_	_
13	complicated	complicated	ADJ	JJ	Degree=Pos	_	_	_	_
14	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
15	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3753
# text = Therefore, we describe a microtitre assay system for glucocorticoid receptors which is a whole-cell competitive binding radioassay using [3H]-dexamethasone as radioligand.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	microtitre	microtitre	NOUN	NN	Number=Sing	_	_	_	_
7	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
8	system	system	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	radioassay	radioassay	NOUN	NN	Number=Sing	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	radioligand	radioligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3754
# text = This modification of a previously described protocol simplifies and reduces laboratory work and allows assay reproducibility to be controlled more reliably.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	protocol	protocol	NOUN	NN	Number=Sing	_	_	_	_
8	simplifies	simplify	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	laboratory	laboratory	ADJ	JJ	Degree=Pos	_	_	_	_
12	work	work	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	assay	assay	ADJ	JJ	Degree=Pos	_	_	_	_
16	reproducibility	reproducibility	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	reliably	reliably	ADV	RB	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3755
# text = Thus enabled to perform the test on multiple blood samples in parallel, we investigated cardiac infarction patients over a 12-day period to test if glucocorticoid receptor binding is altered in this 'stressful' disease.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	enabled	enable	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	perform	perform	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	test	test	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
17	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
18	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
19	over	over	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	day	day	NOUN	NN	Number=Sing	_	_	_	_
24	period	period	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
27	if	if	SCONJ	IN	_	_	_	_	_
28	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
36	stressful	stressful	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	'	'	PUNCT	''	_	_	_	_	_
38	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3756
# text = On the first day of the disease, glucocorticoid receptor capacity was significantly decreased without alteration of the receptor-ligand affinity, whereas on days 4 and 12 the number of receptor sites was normal again.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
4	day	day	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	without	without	ADP	IN	_	_	_	_	_
16	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
22	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	days	day	NOUN	NNS	Number=Plur	_	_	_	_
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	12	12	NUM	CD	NumType=Card	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	number	number	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
37	again	again	ADV	RB	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3757
# text = This result fits well into the general observation of stress-induced down-regulation of immune responses.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	fits	fit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
8	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3758
# text = Document 003003563 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003563	003003563	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3759
# text = The suppression of T cell function and NF(kappa)B expression by serine protease inhibitors is blocked by N-acetylcysteine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
16	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3760
# text = Direct evidence that N-acetylcysteine (NAC) enhances the immune response of peripheral blood T cells at the level of NF(kappa)B is presented.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	presented	presented	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3761
# text = In addition, NAC blocks the suppression of T cell mitogenesis and cytokine production by protease inhibitors such as N-tosylphenylalanine chloromethyl ketone (TPCK).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
5	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
18	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	tosylphenylalanine	tosylphenylalanine	NUM	CD	NumType=Card	_	_	_	_
23	chloromethyl	chloromethyl	NOUN	NN	Number=Sing	_	_	_	_
24	ketone	ketone	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TPCK	TPCK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3762
# text = The proliferative responses of purified CD4+ or CD8+ T cells are suppressed more strongly by TPCK when anti-CD28 rather than the phorbol ester PMA is used as the mitogenic coactivator.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
3	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	+	+	SYM	SYM	_	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	strongly	strongly	ADV	RB	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TPCK	TPCK	NUM	CD	NumType=Card	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
21	rather	rather	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
25	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
26	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
32	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3763
# text = Cytokine (IL-2, IL-6, INF-gamma) production is inhibited 95-100% by concentrations of TPCK that totally suppress the mitogenesis of CD4+ or CD8+ cells.
1	Cytokine	Cytokine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	INF	Inf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	TPCK	TPCK	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	totally	totally	ADV	RB	_	_	_	_	_
28	suppress	suppress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	+	+	SYM	SYM	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3764
# text = Using electrophoretic mobility shift assays, we find that TPCK virtually abolishes (to less than 1%) the levels of NF(kappa)B (but not Oct-1) found in nuclear and whole cell extracts of activated T cells.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	TPCK	Tpck	NOUN	NN	Number=Sing	_	_	_	_
11	virtually	virtually	ADV	RB	_	_	_	_	_
12	abolishes	abolish	ADV	RB	_	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	to	to	ADP	IN	_	_	_	_	_
15	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	ADV	RB	_	_	_	_	_
31	Oct	Oct	ADV	RB	_	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	X	LS	_	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	T	T	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3765
# text = Strikingly, the immunosuppressive effects of TPCK are blocked when T cells are pretreated for 15 min with 5 mM NAC.
1	Strikingly	strikingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TPCK	Tpck	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	15	15	NUM	CD	NumType=Card	_	_	_	_
17	min	min	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	_
20	mM	mm	PROPN	NNP	Number=Sing	_	_	_	_
21	NAC	Nac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3766
# text = NAC not only blocks the effect of TPCK but enhances mitogenesis and cytokine production (>2.5-fold in some cases) upon activation of unsuppressed T cells.
1	NAC	Nac	NOUN	NN	Number=Sing	_	_	_	_
2	not	not	ADV	RB	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TPCK	TPCK	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
11	mitogenesis	mitogenesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	>	>	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	some	some	DET	DT	_	_	_	_	_
22	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	unsuppressed	unsuppressed	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3767
# text = Our data support the notion that NF(kappa)B and I(kappa)B proteases play obligate roles in T cell activation and mitogenesis, roles that are enhanced significantly by NAC.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
19	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	obligate	obligate	ADJ	JJ	Degree=Pos	_	_	_	_
21	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	significantly	significantly	ADV	RB	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3768
# text = Document 003003571 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003571	003003571	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3769
# text = Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor EF1.
1	Detection	detection	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	EF1	Ef1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3770
# text = The erythroid transcription factor erythroid factor-1 (EF1) plays a critical role in the transcription of erythroid-specific genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	EF1	Ef1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3771
# text = Here we report the presence of a factor with the mobility and sequence-specific DNA-binding characteristics of EF1 at low abundance in a wide variety of non-erythroid cell types.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	EF1	Ef1	NOUN	NN	Number=Sing	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
24	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
28	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3772
# text = This is the first report of an EF1-like activity in non-erythroid cells and indicates that this factor may play a role in the regulation of genes expressed in such cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	EF	EF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	role	role	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3773
# text = Document 003003578 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003578	003003578	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3774
# text = A newly established megakaryoblastic/erythroid cell line that differentiates to red cells in the presence of erythropoietin and produces platelet-like particles.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	newly	newly	ADV	RB	_	_	_	_	_
3	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	differentiates	differentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	produces	produce	NOUN	NNS	Number=Plur	_	_	_	_
21	platelet	platelet	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
24	particles	particle	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3775
# text = In August, 1992, we established a leukemic cell line (NS-Meg) from a patient in megakaryoblastic transformation of Philadelphia chromosome-positive chronic myeloid leukemia.
1	In	in	ADP	IN	_	_	_	_	_
2	August	August	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	1992	1992	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	established	establish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NS	NS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
22	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Philadelphia	Philadelphia	PROPN	NNP	Number=Sing	_	_	_	_
25	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
28	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
29	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3776
# text = The NS-Meg cells were positive for alpha-naphthyl acetate esterase and periodic acid-Schiff (PAS) staining and for surface CD4, CD7, CD13, CD34, CD41a, and glycophorin A antigens.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NS	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	naphthyl	naphthyl	ADJ	JJ	Degree=Pos	_	_	_	_
12	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
13	esterase	esterase	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	periodic	periodic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Schiff	Schiff	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PAS	PAS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
26	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	CD7	CD7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	CD13	CD13	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	CD41a	CD41a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	glycophorin	glycophorin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
38	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3777
# text = Ultrastructurally, the cells had alpha-granules, demarcation membranes, and platelet peroxidase activity.
1	Ultrastructurally	Ultrastructurally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	demarcation	demarcation	NOUN	NN	Number=Sing	_	_	_	_
11	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
15	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3778
# text = The NS-Meg cells spontaneously produced platelet-like particles which contained alpha-granules, mitochondria and dense bodies, strongly suggesting platelet production.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NS	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	spontaneously	spontaneously	ADV	RB	_	_	_	_	_
7	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	particles	particle	NOUN	NNS	Number=Plur	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	mitochondria	mitochondria	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	dense	dense	NOUN	NN	Number=Sing	_	_	_	_
21	bodies	bodie	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	strongly	strongly	ADV	RB	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
26	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3779
# text = Erythropoietin (Epo), granulocyte/macrophage colony stimulating factor(GM-CSF), and interleukin 3 (IL-3) promoted the growth of NS-Meg cells.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
10	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NS	NS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3780
# text = Phorbol-12-myristate-13-acetate increased the expression of both CD41a and CD61 antigens.
1	Phorbol	Phorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-12-myristate	-12-myristate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	CD41	CD41	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD61	Cd61	NOUN	NN	Number=Sing	_	_	_	_
14	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3781
# text = Ten-day exposure to Epo induced mature erythroblasts and red cells.
1	Ten	ten	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-day	-day	NOUN	NN	Number=Sing	_	_	_	_
3	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
8	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3782
# text = These benzidine-positive cells were positive for hemoglobin F staining.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	benzidine	benzidine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	_
10	F	f	SCONJ	IN	_	_	_	_	_
11	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3783
# text = Untreated NS-Meg cells expressed mRNA for the Epo receptor (EpoR), for GATA-1, and for alpha 1, alpha 2 and gamma globin genes.
1	Untreated	untreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NS	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3784
# text = These results indicate that NS-Meg cells undergo terminal differentiation of both megakaryocytic and erythroid lineages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NS	NS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	undergo	undergo	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3785
# text = This cell line should be a very useful tool for the investigation of both megakaryocytic and erythroid maturation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	line	line	NOUN	NN	Number=Sing	_	_	_	_
4	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
9	tool	tool	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3786
# text = Document 003003583 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003583	003003583	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3787
# text = Cytomegalovirus modulates interleukin-6 gene expression.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3788
# text = Complications after lung transplantation include the development of rejection and an increased incidence of infection, particularly with cytomegalovirus (CMV).
1	Complications	complication	NOUN	NNS	Number=Plur	_	_	_	_
2	after	after	ADP	IN	_	_	_	_	_
3	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
4	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	_
5	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	development	development	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	incidence	incidence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	particularly	particularly	ADV	RB	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3789
# text = Several recent studies have suggested that interleukin (IL)-6 may be used to detect both infection and rejection after lung transplantation.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
22	after	after	ADP	IN	_	_	_	_	_
23	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
24	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3790
# text = In addition, IL-6 may play a role in the development of bronchiolitis obliterans after transplantation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	bronchiolitis	bronchiolitis	NOUN	NN	Number=Sing	_	_	_	_
16	obliterans	obliteran	NOUN	NNS	Number=Plur	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3791
# text = Because CMV is also associated with the development of bronchiolitis obliterans after transplantation, we determined whether CMV induces IL-6 gene expression.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	development	development	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	bronchiolitis	bronchiolitis	NOUN	NN	Number=Sing	_	_	_	_
11	obliterans	obliteran	NOUN	NNS	Number=Plur	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	whether	whether	SCONJ	IN	_	_	_	_	_
18	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
19	induces	induce	PROPN	NNPS	Number=Plur	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3792
# text = We demonstrated that CMV infection increased both IL-6 protein and mRNA in peripheral blood mononuclear cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	both	both	CCONJ	CC	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3793
# text = We also demonstrated that the CMV immediate early 1 gene product increased expression of the IL-6 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CMV	Cmv	NOUN	NN	Number=Sing	_	_	_	_
7	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
8	early	early	ADV	RB	Degree=Pos	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	product	product	NOUN	NN	Number=Sing	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3794
# text = This effect of the CMV immediate early 1 gene product was dependent upon the presence of specific transcription factor binding sites in the IL-6 promoter.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
6	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
7	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	product	product	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	upon	upon	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3795
# text = These studies demonstrate that CMV may be an important cofactor in the development of rejection and infection after transplantation through its effects on IL-6.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3796
# text = Document 003003585 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003585	003003585	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3797
# text = Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators: comparative study with normal human neutrophils or transformed cells and the putative roles in functionality and cell biology.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	comparative	comparative	ADJ	JJ	Degree=Pos	_	_	_	_
15	study	study	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
26	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	functionality	functionality	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	biology	biology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3798
# text = Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL) -3 induced tyrosine phosphorylation of 92-kDa protein in normal human monocytes.
1	Granulocyte	Granulocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-stimulating	-stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	3	3	X	LS	_	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3799
# text = We identified this 92-kDa protein as STAT5, but not as STATs1, 3, and 6 nor c-fes and vav protooncogene products, and demonstrated its translocation to the nucleus, enhancement of specific DNA binding capacity, and potentiation of trancriptional activity by GM-CSF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	STATs1	STATs1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	nor	nor	CCONJ	CC	_	_	_	_	_
21	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	fes	fe	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	vav	vave	NOUN	NN	Number=Sing	_	_	_	_
26	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
27	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
41	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
42	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	trancriptional	trancriptional	ADJ	JJ	Degree=Pos	_	_	_	_
48	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3800
# text = N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) induced tyrosine phosphorylation of 42- and 44-kDa proteins, which were identified as extracellular signal-regulated kinase (ERK), in human monocytes.
1	N-formyl-methionyl-leucyl-phenylalanine	N-formyl-methionyl-leucyl-phenylalanine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	FMLP	FMLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
7	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
8	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	42	42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	44	44	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3801
# text = In marked contrast to neutrophils and MO7e cells, GM-CSF did not induce tyrosine phosphorylation and activation of ERK in monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	MO7e	MO7e	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3802
# text = Among upstream signaling molecules of ERK, Shc was constitutively associated with Grb2 and was not tyrosine-phosphorylated by GM-CSF and FMLP, and Sos1 and c-Raf-1 were not phosphorylated by GM-CSF, IL-3, TNF, and FMLP in monocytes, whereas all these signaling molecules were affected and/or utilized by GM-CSF in MO7e cells.
1	Among	among	ADP	IN	_	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Shc	Shc	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	constitutively	constitutively	ADV	RB	_	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	Grb2	Grb2	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	FMLP	FMLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Sos1	Sos1	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	FMLP	FMLP	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	monocytes	monocytes	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	whereas	whereas	SCONJ	IN	_	_	_	_	_
54	all	all	DET	DT	_	_	_	_	_
55	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
56	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
57	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
58	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
59	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
61	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
62	or	or	CCONJ	CC	_	_	_	_	_
63	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
64	by	by	ADP	IN	_	_	_	_	_
65	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
68	in	in	ADP	IN	_	_	_	_	_
69	MO7e	MO7e	PROPN	NNP	Number=Sing	_	_	_	_
70	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3803
# text = In contrast to neutrophils, p38 was constitutively phosphorylated and agonist-dependent phosphorylation and activation was not detected in human monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	p38	p38	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	phosphorylated	phosphorylate	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3804
# text = Superoxide release stimulated by FMLP was inhibited partially by PD98059 or SB203580, a specific inhibitor of ERK or p38 pathway, and was almost completely inhibited by the combination of both inhibitors, whereas PMA-induced superoxide release was resistant to these two inhibitors in monocytes.
1	Superoxide	Superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
2	release	release	NOUN	NN	Number=Sing	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	FMLP	FMLP	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	partially	partially	ADV	RB	_	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	SB	Sb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	203580	203580	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	p38	p38	NUM	CD	NumType=Card	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	almost	almost	ADV	RB	_	_	_	_	_
27	completely	completely	ADV	RB	_	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	both	both	DET	DT	_	_	_	_	_
34	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	whereas	whereas	SCONJ	IN	_	_	_	_	_
37	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	superoxide	superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
40	release	release	NOUN	NN	Number=Sing	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
45	two	two	NUM	CD	NumType=Card	_	_	_	_
46	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3805
# text = PD98059 inhibited GM-CSF-dependent proliferation of MO7e cells.
1	PD98059	Pd98059	NOUN	NN	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	GM-	GM-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MO7e	MO7e	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3806
# text = Present results indicate trancriptional roles of STAT5 and functional roles of ERK and/or p38 in normal human monocytes stimulated by physiological receptor-mediated agonists GM-CSF and FMLP.
1	Present	present	ADJ	JJ	Degree=Pos	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	trancriptional	trancriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	or	or	CCONJ	CC	_	_	_	_	_
16	p38	p38	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	FMLP	FMLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3807
# text = Possible roles of ERK in proliferation of transformed cells were also suggested.
1	Possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
2	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transformed	transformed	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3808
# text = Document 003003587 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003587	003003587	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3809
# text = Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.
1	Elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
3	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	kappaB-	kappaB-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3810
# text = The NF-kappaB/Rel family of transcription factors regulates the inducible expression of many genes in activated human monocytes and endothelial cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3811
# text = In this study, we examined the molecular mechanism by which agents that elevate intracellular cAMP inhibit the expression of the tumor necrosis factor alpha (TNFalpha), tissue factor, endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1 genes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	which	which	DET	WDT	PronType=Int	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	elevate	elevate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	_
17	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
23	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	tissue	tissue	ADP	IN	_	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
34	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
44	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3812
# text = Both forskolin and dibutyryl cAMP, which elevate intracellular cAMP by independent mechanisms, inhibited TNFalpha and tissue factor expression at the level of transcription.
1	Both	both	DET	DT	_	_	_	_	_
2	forskolin	forskolin	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	dibutyryl	dibutyryl	NOUN	NN	Number=Sing	_	_	_	_
5	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	elevate	elevate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3813
# text = Induction of NF-kappaB-dependent gene expression in transiently transfected human monocytic THP-1 cells and human umbilical vein endothelial cells was inhibited by elevated cAMP and by overexpression of the catalytic subunit of protein kinase A (PKA).
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF-kappaB	Nf-kappab	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	transiently	transiently	ADV	RB	_	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
20	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
34	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
38	A	A	PROPN	NNP	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3814
# text = Elevated cAMP did not prevent nuclear translocation of p50/p65 and c-Rel/p65 heterodimers, decrease nuclear translocation of p65, or significantly modify TNFalpha-induced phosphorylation of p65.
1	Elevated	elevated	PROPN	NNP	Number=Sing	_	_	_	_
2	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	p50/	p50/	SYM	SYM	_	_	_	_	SpaceAfter=No
10	p65	p65	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	modify	modify	VERB	VB	VerbForm=Inf	_	_	_	_
27	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3815
# text = Functional studies demonstrated that transcriptional activation of a plasmid containing multimerized kappaB sites by p65 was inhibited by agents that elevate cAMP and by overexpression of the catalytic subunit of PKA.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	elevate	elevate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3816
# text = This study indicates that activation of PKA reduces the induction of a distinct set of genes in monocytes and endothelial cells by inhibiting NF-kappaB-mediated transcription.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	_
8	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	set	set	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3817
# text = Document 003003588 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003588	003003588	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3818
# text = The Epstein-Barr virus (EBV) BMRF1 promoter for early antigen (EA-D) is regulated by the EBV transactivators, BRLF1 and BZLF1, in a cell-specific manner.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	BMRF1	BMRF1	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EA	Ea	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
24	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	BRLF1	BRLF1	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3819
# text = The Epstein-Barr virus early antigen diffuse component (EA-D) is essential for Epstein-Barr virus DNA polymerase activity, and its activity is suppressed during latent infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
8	diffuse	diffuse	NOUN	NN	Number=Sing	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EA	Ea	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
28	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	during	during	ADP	IN	_	_	_	_	_
33	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
34	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3820
# text = We investigated the regulation of the promoter (BMRF1) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators, BZLF1 (Z) and BRLF1 (R), focusing on the differences in response in lymphoid cells and epithelial cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	BMRF1	BMRF1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	BZLF	BZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Z	Z	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	BRLF1	BRLF1	PROPN	NNP	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	focusing	focus	VERB	VBG	VerbForm=Ger	_	_	_	_
41	on	on	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	response	response	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3821
# text = In lymphoid cells, Z or R alone produced only small increases in EA-D promoter activity, whereas both transactivators together produced a large stimulatory effect.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	R	be	PROPN	NNP	Number=Sing	_	_	_	_
8	alone	alone	ADV	RB	_	_	_	_	_
9	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
12	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EA	EA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	D	D	PROPN	NNP	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	whereas	whereas	SCONJ	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
23	together	together	ADV	RB	_	_	_	_	_
24	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
27	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3822
# text = In epithelial cells, the Z transactivator alone produced maximal stimulation of the EA-D promoter; the effect of R and Z together was no greater than that of Z alone.
1	In	in	ADP	IN	_	_	_	_	_
2	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
8	alone	alone	ADV	RB	_	_	_	_	_
9	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	EA	EA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	D	D	PROPN	NNP	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	R	R	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
25	together	together	ADV	RB	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	no	no	ADV	RB	_	_	_	_	_
28	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
33	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3823
# text = Deletional analysis and site-directed mutagenesis of the EA-D promoter demonstrated that in epithelial cells the potential AP-1 binding site plays an essential role in Z responsiveness, although sequences further upstream are also important.
1	Deletional	Deletional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	EA	Ea	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	D	d	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
32	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	although	although	SCONJ	IN	_	_	_	_	_
35	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
36	further	further	ADV	RB	_	_	_	_	_
37	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	also	also	ADV	RB	_	_	_	_	_
40	important	important	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3824
# text = In lymphoid cells, only the upstream sequences are required for transactivation by the Z/R combination, and the AP-1 site is dispensable.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Z/R	Z/R	PROPN	NNP	Number=Sing	_	_	_	_
16	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3825
# text = These data suggest that EA-D (BMRF1) promoter regulation by Z and R is cell type specific and appears to involve different mechanisms in each cell type.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	EA	Ea	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	D	d	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	BMRF1	BMRF1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	R	R	PROPN	NNP	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	each	each	DET	DT	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3826
# text = Document 003003589 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003589	003003589	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3827
# text = Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma.
1	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-6	-6	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
6	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
7	hyperplasia	hyperplasia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	angioimmunoblastic	angioimmunoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	hyperplastic	hyperplastic	ADJ	JJ	Degree=Pos	_	_	_	_
19	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
20	centers	center	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	heterogeneity	heterogeneity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	altered	alter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	angioimmunoblastic	angioimmunoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3828
# text = BACKGROUND: The Bcl-6 gene product, a nuclear phosphoprotein, is expressed independently of Bcl-6 gene rearrangement.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	independently	independently	ADV	RB	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3829
# text = In lymph nodes, expression of Bcl-6 protein is restricted to germinal center (GC) B-cells and 10% to 15% of CD3/CD4+ intrafollicular
1	In	in	ADP	IN	_	_	_	_	_
2	lymph	lymph	ADJ	JJ	Degree=Pos	_	_	_	_
3	nodes	node	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	germinal	germinal	VERB	VB	VerbForm=Inf	_	_	_	_
15	center	center	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	GC	GC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	%	%	SYM	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	%	%	SYM	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	CD3/CD4	CD3/CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	+	+	SYM	SYM	_	_	_	_	_
31	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3830
# text = T cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3831
# text = Interfollicular cells are negative for Bcl-6 protein, except for rare CD3+/CD4+ T cells.
1	Interfollicular	Interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	except	except	ADP	IN	_	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
14	CD3+/CD4	CD3+/CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3832
# text = Recently, we reported cases of angioimmunoblastic T-cell lymphoma (AITL) with hyperplastic GCs (AITL/GC), and observed that borders of enlarged GCs were ill defined, with features suggestive of an outward migration of GC cells to surrounding interfollicular zones.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	cases	casis	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	angioimmunoblastic	angioimmunoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
8	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	AITL	AITL	INTJ	UH	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	hyperplastic	hyperplastic	ADJ	JJ	Degree=Pos	_	_	_	_
16	GCs	GC	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	AITL/	AITL/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	GC	GC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	borders	border	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	enlarged	enlarge	ADJ	JJ	Degree=Pos	_	_	_	_
28	GCs	Gcs	NOUN	NNS	Number=Plur	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	ill	ill	ADV	RB	_	_	_	_	_
31	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	with	with	SCONJ	IN	_	_	_	_	_
34	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
35	suggestive	suggestive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	outward	outward	ADJ	JJ	Degree=Pos	_	_	_	_
39	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
43	to	to	SCONJ	IN	_	_	_	_	_
44	surrounding	surround	VERB	VBG	VerbForm=Ger	_	_	_	_
45	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
46	zones	zone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3833
# text = This prompted a study of follicular borders with Bcl-6 staining in reactive follicular hyperplasias and follicular lymphomas to compare with AITL/GC.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	prompted	prompt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
7	borders	border	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
15	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
16	hyperplasias	hyperplasia	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	compare	compare	VERB	VB	VerbForm=Inf	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3834
# text = MATERIALS AND METHODS: Formalin-fixed paraffin sections were used for immunostaining of Bcl-6.
1	MATERIALS	material	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Formalin	Formalin	ADP	IN	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	paraffin	paraffin	NOUN	NN	Number=Sing	_	_	_	_
9	sections	section	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	immunostaining	immunostaining	VERB	VBG	VerbForm=Ger	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3835
# text = Six cases of AITL/GC, 12 nonspecific reactive follicular hyperplasia (FH), 7 HIV adenopathy, 10 follicular lymphoma (FL), and 8 typical AITL (ie, AITL without GC) were studied.
1	Six	six	NUM	CD	NumType=Card	_	_	_	_
2	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AITL/GC	AITL/GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	12	12	NUM	CD	NumType=Card	_	_	_	_
7	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
8	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
9	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
10	hyperplasia	hyperplasia	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	FH	FH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	7	7	NUM	CD	NumType=Card	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
17	adenopathy	adenopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	10	10	NUM	CD	NumType=Card	_	_	_	_
20	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	FL	FL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	8	8	NUM	CD	NumType=Card	_	_	_	_
28	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
29	AITL	Aitl	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	AITL	AITL	ADV	RB	_	_	_	_	_
34	without	without	ADP	IN	_	_	_	_	_
35	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3836
# text = Double staining for Bcl-6/CD20, Bcl-6/CD3, and Bcl-6/CD57 was performed in selected cases.
1	Double	double	ADJ	JJ	Degree=Pos	_	_	_	_
2	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	Bcl-6/CD20	Bcl-6/CD20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Bcl-6/CD3	Bcl-6/CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Bcl-6/CD57	Bcl-6/CD57	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cases	casis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3837
# text = RESULTS: In FH and HIV adenopathy, staining for Bcl-6 revealed densely populated GCs with well-defined and regular GC borders, whereas Bcl-6+ cells were rare in the interfollicular areas.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	FH	FH	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
7	adenopathy	adenopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	densely	densely	ADV	RB	_	_	_	_	_
16	populated	populate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	GCs	GC	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	regular	regular	ADJ	JJ	Degree=Pos	_	_	_	_
24	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
25	borders	border	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	whereas	whereas	SCONJ	IN	_	_	_	_	_
28	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	+	+	SYM	SYM	_	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
38	areas	area	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3838
# text = An occasional GC with an ill-defined border was invariably surrounded by a broad mantle zone; those with indistinct mantle zones had well-defined, regular borders.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	occasional	occasional	ADJ	JJ	Degree=Pos	_	_	_	_
3	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	ill	ill	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	border	border	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	invariably	invariably	ADV	RB	_	_	_	_	_
12	surrounded	surround	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	broad	broad	ADJ	JJ	Degree=Pos	_	_	_	_
16	mantle	mantle	NOUN	NN	Number=Sing	_	_	_	_
17	zone	zone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	indistinct	indistinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	mantle	mantle	NOUN	NN	Number=Sing	_	_	_	_
23	zones	zone	NOUN	NNS	Number=Plur	_	_	_	_
24	had	have	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	regular	regular	ADJ	JJ	Degree=Pos	_	_	_	_
30	borders	border	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3839
# text = In FL, follicles were densely populated, and their borders were irregular, with some Bcl-6+ cells in the interfollicular zones.
1	In	in	ADP	IN	_	_	_	_	_
2	FL	FL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	follicles	follicle	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	densely	densely	ADV	RB	_	_	_	_	_
7	populated	populate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	borders	border	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	irregular	irregular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	some	some	DET	DT	_	_	_	_	_
17	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
25	zones	zone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3840
# text = In AITL/GC, GCs were less dense, GC borders were ill defined and irregular, and the number of interfollicular Bcl-6+ cells was markedly increased.
1	In	in	ADP	IN	_	_	_	_	_
2	AITL/GC	AITL/GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	GCs	Gcs	PROPN	NNP	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
7	dense	dense	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	GC	Gc	ADJ	JJ	Degree=Pos	_	_	_	_
10	borders	border	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	ill	ill	AUX	MD	VerbForm=Fin	_	_	_	_
13	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	irregular	irregular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	number	number	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
22	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	markedly	markedly	ADV	RB	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3841
# text = Double staining revealed that these interfollicular Bcl-6+ cells in AITL/GC were Bcl6+/CD3+/CD20-/CD57-
1	Double	double	ADJ	JJ	Degree=Pos	_	_	_	_
2	staining	stai	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
7	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	AITL/	AITLith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	Bcl6+/CD3+/CD20-/CD57-	Bcl6+/CD3+/CD20-/CD57-	SYM	NFP	_	_	_	_	_

# sent_id = 3842
# text = T cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3843
# text = Moreover, CD3+ intrafollicular
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	_
5	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3844
# text = T cells were depleted in AITL/GC, whereas they were abundant in FH.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	AITL/GC	AITL/GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	whereas	whereas	SCONJ	IN	_	_	_	_	_
9	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	abundant	abundant	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	FH	FH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3845
# text = Intrafollicular CD57+ cells did not stain for Bcl-6, and were also depleted in AITL/GC.
1	Intrafollicular	Intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
2	CD57	CD57	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	+	+	SYM	SYM	_	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	stain	stain	VERB	VB	VerbForm=Inf	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/GC	/GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3846
# text = In typical AITL, some neoplastic cells were positive for Bcl-6, showing variable degrees of staining.
1	In	in	ADP	IN	_	_	_	_	_
2	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
3	AITL	Aitl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	some	some	DET	DT	_	_	_	_	_
6	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
15	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
16	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	staining	staining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3847
# text = CONCLUSIONS: (1) GCs of AITL/GC differed from those of other reactive follicular hyperplasias and follicular lymphomas, and staining for Bcl-6 was useful to discern them.
1	CONCLUSIONS	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	1	1	X	LS	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	GCs	Gcs	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
11	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
18	hyperplasias	hyperplasia	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	discern	discern	VERB	VB	VerbForm=Inf	_	_	_	_
33	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3848
# text = (2)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	2	2	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 3849
# text = Intrafollicular CD3+ T cells, many of which were also positive for Bcl-6, were markedly depleted in AITL/GC, with increased interfollicular Bcl-6+/CD3+ cells, suggesting an outward migration of intrafollicular
1	Intrafollicular	Intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
2	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	+	+	SYM	SYM	_	_	_	_	_
4	T	t	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Int	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	markedly	markedly	ADV	RB	_	_	_	_	_
19	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
28	Bcl-6+/CD3	Bcl-6+/CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	outward	outward	ADJ	JJ	Degree=Pos	_	_	_	_
35	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3850
# text = T cells in this condition.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	condition	condition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3851
# text = (3) Interfollicular Bcl-6+/CD3+ cells in AITL/GC were too numerous to be accounted for by migration alone, suggesting local proliferation.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	3	3	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Interfollicular	Interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
5	Bcl-6+/CD3	Bcl-6+/CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	too	too	ADV	RB	_	_	_	_	_
14	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	accounted	account	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
21	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	local	local	ADJ	JJ	Degree=Pos	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3852
# text = (4) Intrafollicular CD57+ cells were negative for Bcl-6, indicating heterogeneity of the intrafollicular T-cell population.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	4	4	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Intrafollicular	Intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
5	CD57	CD57	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	heterogeneity	heterogeneity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3853
# text = (5) Some neoplastic cells in AITL stained for Bcl-6, suggesting up-regulation of Bcl-6 expression in this tumor.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	5	5	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Some	some	DET	DT	_	_	_	_	_
5	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	_
9	stained	stain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	tumor.	tumor.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3854
# text = Document 003003593 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003593	003003593	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3855
# text = Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription
1	Staphylococcal	Staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
2	enterotoxins	enterotoxin	NOUN	NNS	Number=Plur	_	_	_	_
3	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
27	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3856
# text = (Stat proteins).
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Stat	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3857
# text = Staphylococcal enterotoxins (SE) stimulate T cells expressing the appropriate variable region beta chain of (V beta) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases.
1	Staphylococcal	Staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
2	enterotoxins	enterotoxin	NOUN	NNS	Number=Plur	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	SE	SE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
12	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	V	V	PROPN	NNP	Number=Sing	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
33	autoimmune	autoimmune	NOUN	NN	Number=Sing	_	_	_	_
34	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3858
# text = Depending on costimulatory signals, SE induce either proliferation or anergy in T cells.
1	Depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	SE	Se	PROPN	NNP	Number=Sing	_	_	_	_
7	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
8	either	either	CCONJ	CC	_	_	_	_	_
9	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3859
# text = In addition, SE can induce an interleukin-2 (IL-2) nonresponsive state and apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	SE	SE	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	nonresponsive	nonresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
17	state	state	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3860
# text = Here, we show that SE induce dynamic changes in the expression of and signal transduction through the IL-2 receptor (IL-2R) beta and gamma chains (IL-2R beta and IL-2R gamma) in human antigen-specific CD4+ T-cell lines.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	SE	SE	PROPN	NNP	Number=Sing	_	_	_	_
7	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dynamic	dynamic	ADJ	JJ	Degree=Pos	_	_	_	_
9	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2R	2r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
36	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
41	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
45	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
47	CD4	Cd4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	+	+	SYM	SYM	_	_	_	_	_
49	T-	t-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3861
# text = Thus, after 4 hr of exposure to SEA and SEB, the expression of IL-2R beta was down-regulated, IL-2R gamma was slightly up-regulated, while IL-2R alpha remained largely unaffected.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	after	after	ADP	IN	_	_	_	_	_
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	SEA	sea	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	SEB	SEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
19	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	R	r	PROPN	NNP	Number=Sing	_	_	_	_
29	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	slightly	slightly	ADV	RB	_	_	_	_	_
32	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	while	while	SCONJ	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
41	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	largely	largely	ADV	RB	_	_	_	_	_
43	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3862
# text = The changes in the composition of IL-2Rs were accompanied by inhibition of IL-2-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription called Stat3 and Stat5.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	Rs	R	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
36	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3863
# text = In parallel experiments, IL-2-driven proliferation was inhibited significantly.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3864
# text = After 16 hr of exposure to SE, the expression of IL-2R beta remained low, while that of IL2R alpha and IL2R gamma was further up-regulated, and ligand-induced tyrosine phosphorylation of Jak3 and Stat proteins was partly normalized.
1	After	after	ADP	IN	_	_	_	_	_
2	16	16	NUM	CD	NumType=Card	_	_	_	_
3	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	SE	SE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL2R	IL2R	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL2R	IL2R	PROPN	NNP	Number=Sing	_	_	_	_
26	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	further	further	ADV	RB	_	_	_	_	_
29	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
38	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
43	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	partly	partly	ADV	RB	_	_	_	_	_
46	normalized	normalize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3865
# text = Yet, IL-2-driven proliferation remained profoundly inhibited, suggesting that signaling events other than Jak3/Stat activation had also been changed following SE stimulation.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
9	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	profoundly	profoundly	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
16	events	event	NOUN	NNS	Number=Plur	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	changed	change	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	SE	Se	ADJ	JJ	Degree=Pos	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3866
# text = In conclusion, our data suggest that SE can modulate IL-2R expression and signal transduction involving the Jak/Stat pathway in CD4+ T-cell lines.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	SE	SE	PROPN	NNP	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
18	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
23	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3867
# text = Document 003003595 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003595	003003595	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3868
# text = The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	56	56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-kilodalton	-kilodalton	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	untransformed	untransformed	ADJ	JJ	Degree=Pos	_	_	_	_
10	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kilodalton	kilodalton	NOUN	NN	Number=Sing	_	_	_	_
33	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
34	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
35	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3869
# text = It has previously been shown that 9S, untransformed progestin, estrogen, androgen, and glucocorticoid receptor complexes in rabbit uterine and liver cytosols contain a 59-kDa protein [Tai, P.K., Maeda, Y., Nakao, K., Wakim, N.G., Duhring, J.L., & Faber, L.E.(1986) Biochemistry 25, 5269-5275].
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	S	s	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	untransformed	untransformed	ADJ	JJ	Degree=Pos	_	_	_	_
11	progestin	progestin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	glucocorticoid	glucocorticoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
23	uterine	uterine	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
26	cytosols	cytosol	NOUN	NNS	Number=Plur	_	_	_	_
27	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	Tai	Tai	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	P.K.	P.K.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	Maeda	Maeda	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	Y.	Y.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	Nakao	Nakao	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	K.	K.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	Wakim	Wakim	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	N.G.	N.G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	Duhring	Duhr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	J.L.	J.L.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	&	&	CCONJ	CC	_	_	_	_	_
55	Faber	Faber	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	L.E.	L.E.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	1986	1986	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	Biochemistry	Biochemistry	NOUN	NN	Number=Sing	_	_	_	_
62	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	5269	5269	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
66	5275	5275	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3870
# text = In this work we show that the monoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with 9S, untransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
10	KN	KN	NOUN	NN	Number=Sing	_	_	_	_
11	382/	382/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
12	EC1	Ec1	PROPN	NNP	Number=Sing	_	_	_	_
13	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	against	against	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
17	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	reacts	react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	S	s	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	untransformed	untransformed	ADJ	JJ	Degree=Pos	_	_	_	_
27	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
32	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	IM	Im	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	9	9	NUM	CD	NumType=Card	_	_	_	_
38	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	S	S	PROPN	NNP	Number=Sing	_	_	_	_
44	salt	salt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3871
# text = The human protein recognized by the EC1 antibody is a 56-kDa protein (p56) of moderate abundance located predominantly in the cytoplasm by indirect immunofluorescence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	EC1	EC1	PROPN	NNP	Number=Sing	_	_	_	_
8	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	56	56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
20	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
21	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	predominantly	predominantly	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
28	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3872
# text = There are at least six isomorphs of p56 by two-dimensional gel analysis.
1	There	there	PRON	EX	_	_	_	_	_
2	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	at	at	ADV	RB	_	_	_	_	_
4	least	least	ADV	RBS	Degree=Sup	_	_	_	_
5	six	six	NUM	CD	NumType=Card	_	_	_	_
6	isomorphs	isomorph	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p56	p56	NUM	CD	NumType=Card	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dimensional	dimensional	ADJ	JJ	Degree=Pos	_	_	_	_
13	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
14	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3873
# text = N-Terminal sequencing (20 amino acids) shows that p56 is a unique human protein.
1	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	Terminal	Terminal	NOUN	NN	Number=Sing	_	_	_	_
3	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	20	20	NUM	CD	NumType=Card	_	_	_	_
6	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
7	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	p56	p56	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3874
# text = When p56 is immunoadsorbed from IM-9 cell cytosol, both the 70- and 90-kDa heat shock proteins are coadsorbed in an immune-specific manner.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	p56	p56	NUM	CD	NumType=Card	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	immunoadsorbed	immunoadsor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	IM	Im	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	9	9	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
20	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
21	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	coadsorbed	coadsor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	immune-specific	immune-specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3875
# text = Neither heat shock protein reacts directly with the EC1 antibody.
1	Neither	neither	DET	DT	_	_	_	_	_
2	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
3	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	reacts	react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	EC1	ec1	PROPN	NNP	Number=Sing	_	_	_	_
10	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3876
# text = We conclude that p56 exists in cytosol in a higher order complex containing hsp70 and hsp90, both of which in turn have been found to be associated with untransformed steroid receptors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	p56	p56	NOUN	NN	Number=Sing	_	_	_	_
5	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	order	order	NOUN	NN	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	hsp70	hsp70	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	hsp90	hsp90	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
23	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	untransformed	untransform	ADJ	JJ	Degree=Pos	_	_	_	_
31	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
32	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3877
# text = Document 003003596 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003596	003003596	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3878
# text = Oncogenicity of human papillomavirus- or adenovirus-transformed cells correlates with resistance to lysis by natural killer cells.
1	Oncogenicity	Oncogenicity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	papillomavirus	papillomavirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	lysis	lysis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
18	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3879
# text = The reasons for the dissimilar oncogenicities of human adenoviruses and human papillomaviruses (HPV) in humans are unknown but may relate to differences in the capacities of the E1A and E7 proteins to target cells for rejection by the host natural killer (NK) cell response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	reasons	reason	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	dissimilar	dissimilar	ADJ	JJ	Degree=Pos	_	_	_	_
6	oncogenicities	oncogenicity	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	adenoviruses	adenoviruse	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	papillomaviruses	papillomaviruse	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	HPV	HPV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	relate	relate	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	capacities	capacity	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	E1A	E1a	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	E7	E7	NUM	CD	NumType=Card	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	host	host	ADV	RBS	_	_	_	_	_
42	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
43	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3880
# text = As one test of this hypothesis, we compared the abilities of E1A- and E7-expressing human fibroblastic or keratinocyte-derived human cells to be selectively killed by either unstimulated or interferon (IFN)-activated NK cells.
1	As	as	SCONJ	IN	_	_	_	_	_
2	one	one	NUM	CD	NumType=Card	_	_	_	_
3	test	test	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	abilities	abilitie	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	E7	E7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-expressing	-expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	fibroblastic	fibroblastic	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	keratinocyte	keratinocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	selectively	selectively	ADV	RB	_	_	_	_	_
29	killed	kill	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	either	either	CCONJ	CC	_	_	_	_	_
32	unstimulated	unstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3881
# text = Cells expressing the E1A oncoprotein were selectively killed by unstimulated NK cells, while the same parental cells but expressing the HPV type 16 (HPV-16) or HPV-18 E7 oncoprotein were resistant to NK cell lysis.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	E1A	E1a	NOUN	NN	Number=Sing	_	_	_	_
5	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	selectively	selectively	ADV	RB	_	_	_	_	_
8	killed	kill	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	unstimulated	unstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
11	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	while	while	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HPV	HPV	PROPN	NNP	Number=Sing	_	_	_	_
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	16	16	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	HPV	Hpv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	HPV	HPV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	18	18	NUM	CD	NumType=Card	_	_	_	_
34	E7	E7	NUM	CD	NumType=Card	_	_	_	_
35	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
40	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
41	lysis	lysis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3882
# text = The ability of IFN-activated NK cells to selectively kill virally transformed cells depends on IFN's ability to induce resistance to NK cell lysis in normal (i.e., non-viral oncogene-expressing) but not virally transformed cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	kill	kill	VERB	VB	VerbForm=Inf	_	_	_	_
12	virally	virally	ADV	RB	_	_	_	_	_
13	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	's	's	PART	POS	_	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	non-viral	non-viral	ADJ	JJ	Degree=Pos	_	_	_	_
33	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	expressing	expressing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	virally	virally	ADV	RB	_	_	_	_	_
40	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3883
# text = E1A blocked IFN's induction of cytolytic resistance, resulting in the selective lysis of adenovirus-transformed cells by IFN-activated NK cells.
1	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	_
2	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	's	's	PART	POS	_	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
14	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3884
# text = The extent of IFN-induced NK cell killing of E1A-expressing cells was proportional to the level of E1A expression and correlated with the ability of E1A to block IFN-stimulated gene expression in target cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	killing	killing	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	proportional	proportional	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	E1	E1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
33	IFN	Ifn	ADV	RB	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	target	target	NOUN	NN	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3885
# text = In contrast, E7 blocked neither IFN-stimulated gene expression nor IFN's induction of cytolytic resistance, thereby precluding the selective lysis of HPV-transformed cells by IFN-activated NK cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	E7	E7	NUM	CD	NumType=Card	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	neither	neither	DET	DT	_	_	_	_	_
7	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	nor	nor	CCONJ	CC	_	_	_	_	_
13	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	's	's	PART	POS	_	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	thereby	thereby	ADV	RB	_	_	_	_	_
21	precluding	preclud	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
24	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	HPV	HPV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3886
# text = In conclusion, E1A expression marks cells for destruction by the host NK cell response, whereas the E7 oncoprotein lacks this activity.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	E1	E1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	marks	mark	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	destruction	destruction	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	host	host	NOUN	NN	Number=Sing	_	_	_	_
14	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	E7	E7	NOUN	NN	Number=Sing	_	_	_	_
21	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	_
22	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3887
# text = Document 003003597 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003597	003003597	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3888
# text = Cloning a cDNA from human NK/T cells which codes for a protein with high proline content.
1	Cloning	Clon	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	NK/T	Nk/t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	codes	code	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	proline	proline	NOUN	NN	Number=Sing	_	_	_	_
16	content	content	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3889
# text = A cDNA clone, B4-2, was isolated from a natural killer (NK) minus T cell subtractive library.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	B4	B4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	minus	minus	CCONJ	CC	_	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	subtractive	subtractive	ADJ	JJ	Degree=Pos	_	_	_	_
22	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3890
# text = The B4-2 clone coded for an mRNA of 2061 bp in length.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B4	B4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
6	coded	cod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	2061	2061	NUM	CD	NumType=Card	_	_	_	_
12	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	length	length	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3891
# text = It encodes a deduced 327 aa protein with a calculated molecular mass of 35.2 kDa.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	deduced	deduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	327	327	NUM	CD	NumType=Card	_	_	_	_
6	aa	a	DET	DT	Typo=Yes	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	calculated	calculate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
12	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	35.2	35.2	NUM	CD	NumType=Card	_	_	_	_
15	kDa.	kDa.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3892
# text = Searching of B4-2 DNA and protein sequences against various databases revealed no high homology to other sequences.
1	Searching	searching	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	B4	B4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	against	against	ADP	IN	_	_	_	_	_
11	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
12	databases	database	NOUN	NNS	Number=Plur	_	_	_	_
13	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
16	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3893
# text = However, B4-2 has an unusually high proline content (13%), contains a putative nuclear targeting sequence, and has several SPXX motifs which are frequently found in gene regulatory proteins.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	B4	B4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	unusually	unusually	ADV	RB	_	_	_	_	_
9	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
10	proline	proline	NOUN	NN	Number=Sing	_	_	_	_
11	content	content	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
27	SPXX	Spxx	NOUN	NN	Number=Sing	_	_	_	_
28	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	frequently	frequently	ADV	RB	_	_	_	_	_
32	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3894
# text = One of the stretches of prolines in B4-2 closely resembles the ligand for proteins with SH3 domains.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	stretches	stretch	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	prolines	proline	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	B4	B4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	closely	closely	ADV	RB	_	_	_	_	_
12	resembles	resemble	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	SH3	SH3	NOUN	NN	Number=Sing	_	_	_	_
19	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3895
# text = Northern hybridization data showed that B4-2 is not a lymphoid specific gene and is expressed in a hepatoma cell line and also weakly transcribed or absent in a variety of other cells.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	B4	B4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	hepatoma	hepatoma	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	weakly	weakly	ADV	RB	_	_	_	_	_
26	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3896
# text = A polyclonal antiserum raised against recombinant B4-2 recognizes a 32-34 kDa protein in lymphocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
3	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
4	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	against	against	ADP	IN	_	_	_	_	_
6	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
7	B4	B4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	recognizes	recognize	NOUN	NNS	Number=Plur	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	34	34	NUM	CD	NumType=Card	_	_	_	_
15	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3897
# text = Document 003003598 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003598	003003598	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3898
# text = Visualization of the endogenous NF-kappa B p50 subunit in the nucleus of follicular dendritic cells in germinal centers.
1	Visualization	visualization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	p50	p50	NUM	CD	NumType=Card	_	_	_	_
10	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
16	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
20	centers	center	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3899
# text = NF-kappa B, a 50 kDa/65 kDa (p50/p65) heterodimer, is a ubiquitous transcription factor involved in the positive regulation of various immune genes.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
4	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	50	50	NUM	CD	NumType=Card	_	_	_	_
8	kDa/65	kDa/65	NOUN	NN	Number=Sing	_	_	_	_
9	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
13	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
29	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3900
# text = The aim of this study was to determine whether NF-kappa B is related to a particular cell type and/or differentiation step during immunopoiesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
9	whether	whether	SCONJ	IN	_	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	or	or	CCONJ	CC	_	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	step	step	NOUN	NN	Number=Sing	_	_	_	_
26	during	during	ADP	IN	_	_	_	_	_
27	immunopoiesis	immunopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3901
# text = Using in situ hybridization on sections from non HIV hyperplastic lymph nodes, we found that the gene of the 105 kDa precursor of p50 was overexpressed in the light zone of germinal centers, with a network aspect, which suggested the involvement of follicular dendritic cells (FDC).
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
4	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	sections	section	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	non	non	PROPN	NNP	Number=Sing	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
10	hyperplastic	hyperplastic	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
12	nodes	node	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	105	105	NUM	CD	NumType=Card	_	_	_	_
22	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
23	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	light	light	NOUN	NN	Number=Sing	_	_	_	_
31	zone	zone	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
34	centers	center	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	network	network	NOUN	NN	Number=Sing	_	_	_	_
39	aspect	aspect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	which	which	PRON	WDT	PronType=Rel	_	_	_	_
42	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
47	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3902
# text = By immunohistochemistry, p50 protein was detected in the cytoplasm and nucleus of FDC, confirming the involvement of FDC.
1	By	by	ADP	IN	_	_	_	_	_
2	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	confirming	confirm	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3903
# text = Furthermore, p50 protein was detected in the cytoplasm of all lymphocytes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	p50	p50	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3904
# text = Thus, we focused our study on isolated FDC clusters from normal tonsils.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	focused	focus	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	FDC	Fdc	NOUN	NN	Number=Sing	_	_	_	_
10	clusters	cluster	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	tonsils	tonsil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3905
# text = As showed on tissue sections, we detected the p50 in both cytoplasm and nucleus of FDC.
1	As	as	SCONJ	IN	_	_	_	_	_
2	showed	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	sections	section	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3906
# text = Nuclei of lymphocytes from FDC clusters were negative.
1	Nuclei	Nuclei	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	_
6	clusters	cluster	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3907
# text = We next studied p65 and c-Rel protein expression in FDC clusters.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	next	next	ADV	RB	_	_	_	_	_
3	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	p65	p65	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	FDC	FDC	ADJ	JJ	Degree=Pos	_	_	_	_
13	clusters	cluster	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3908
# text = p65 was detected in the cytoplasm of FDC, whereas nuclei were negative.
1	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	whereas	whereas	SCONJ	IN	_	_	_	_	_
11	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3909
# text = Furthermore, p65 was detected in the nuclei of some lymphocytes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	some	some	DET	DT	_	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3910
# text = c-Rel protein was detected only in the cytoplasm of lymphocytes and not in the nucleus and cytoplasm of FDC.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3911
# text = Our results indicated that, in the context of T cell-dependent B cell immunopoiesis occurring in FDC clusters, p50 is mainly related to FDC with a massive overexpression in the nuclei, whereas p65 is expressed in a scattered manner in the nuclei of lymphocytes and c-Rel protein exclusively in the cytoplasm of lymphocytes from FDC clusters.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	context	context	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	immunopoiesis	immunopoiesis	NOUN	NN	Number=Sing	_	_	_	_
17	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	_
20	clusters	cluster	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	mainly	mainly	ADV	RB	_	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	massive	massive	ADJ	JJ	Degree=Pos	_	_	_	_
31	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	whereas	whereas	SCONJ	IN	_	_	_	_	_
37	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	scattered	scatter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
53	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
54	exclusively	exclusively	ADV	RB	_	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
60	from	from	ADP	IN	_	_	_	_	_
61	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	_
62	clusters	cluster	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3912
# text = These results suggested that the two subunits of NF-kappa B and the c-Rel protein have different roles in different cell types during B cell immunopoiesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	types	type	NOUN	NNS	Number=Plur	_	_	_	_
26	during	during	ADP	IN	_	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	immunopoiesis	immunopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3913
# text = Document 003003607 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003607	003003607	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3914
# text = Sp1 functions in a chromatin-dependent manner to augment human alpha-globin promoter activity.
1	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3915
# text = The 5' flanking region of the human alpha-globin gene is highly G + C rich and contains multiple copies of the consensus sequence for the Sp1 binding site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	PUNCT	``	_	_	_	_	_
4	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	highly	highly	ADV	RB	_	_	_	_	_
15	G	G	ADJ	JJ	Degree=Pos	_	_	_	_
16	+	+	SYM	SYM	_	_	_	_	_
17	C	C	PROPN	NNP	Number=Sing	_	_	_	_
18	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
22	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3916
# text = We investigated the role of this G + C-rich region in augmenting alpha-globin promoter activity in the presence of the far-upstream alpha-globin enhancer, HS-40.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	G	g	NOUN	NN	Number=Sing	_	_	_	_
8	+	+	SYM	SYM	_	_	_	_	_
9	C-	C-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
14	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	far-	far-	X	AFX	_	_	_	_	SpaceAfter=No
25	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3917
# text = We show that in transiently transfected erythroid cells, deletion of the alpha-globin G + C-rich 5' flanking region has no effect on alpha-globin promoter activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	transiently	transiently	ADV	RB	_	_	_	_	_
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
16	G	g	NOUN	NN	Number=Sing	_	_	_	_
17	+	+	SYM	SYM	_	_	_	_	_
18	C-	C-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	``	_	_	_	_	_
22	flanking	flanking	NOUN	NN	Number=Sing	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	no	no	DET	DT	_	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3918
# text = However, upon stable integration into chromatin, deletion of this region causes a nearly 90% decrease in promoter activity compared with expression from an alpha-globin promoter retaining this region.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	upon	upon	ADP	IN	_	_	_	_	_
4	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
5	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	nearly	nearly	ADV	RB	_	_	_	_	_
16	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	%	%	SYM	NN	Number=Sing	_	_	_	_
18	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	retaining	retain	VERB	VBG	VerbForm=Ger	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3919
# text = These results suggest that the alpha-globin G + C-rich 5' flanking region augments alpha-globin promoter activity in a chromatin-dependent manner.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
9	G	g	NOUN	NN	Number=Sing	_	_	_	_
10	+	+	SYM	SYM	_	_	_	_	_
11	C-	C-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3920
# text = We further show that this G + C-rich region is required for the activation of alpha-globin gene expression during erythroid differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	G	g	NOUN	NN	Number=Sing	_	_	_	_
7	+	+	SYM	SYM	_	_	_	_	_
8	C-	C-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3921
# text = Finally, we show by both footprint analysis and functional assays that the ability of the G + C-rich region to increase alpha-globin promoter activity from a stably integrated alpha-globin gene is mediated by its multiple binding sites for the transcription factor Sp1.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	G	g	PROPN	NNP	Number=Sing	_	_	_	_
18	+	+	SYM	SYM	_	_	_	_	_
19	C-	C-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
24	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	stably	stably	ADV	RB	_	_	_	_	_
32	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
41	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
42	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
43	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
48	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3922
# text = Document 003003608 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003608	003003608	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3923
# text = A central role for a single c-Myb binding site in a thymic locus control region.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
15	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3924
# text = Locus control regions (LCRs) are powerful assemblies of cis elements that organize the actions of cell-type-specific trans-acting factors.
1	Locus	Locus	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	LCRs	LCR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
9	assemblies	assembly	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	organize	organize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3925
# text = A 2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron, which controls expression in thymocytes, is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	2.3	2.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
5	LCR	Lcr	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
10	deaminase	deaminase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ADA	ada	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	gene	gene	PRON	NN	Number=Sing	_	_	_	_
15	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	200	200	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	extended	extend	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
36	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
37	that	that	PRON	WDT	PronType=Rel	_	_	_	_
38	facilitate	facilitate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	within	within	ADP	IN	_	_	_	_	_
42	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3926
# text = Prior analyses have demonstrated that the enhancer contains a 28-bp core region and local adjacent augmentative cis elements.
1	Prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	28	28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
13	core	core	NOUN	NN	Number=Sing	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	local	local	ADJ	JJ	Degree=Pos	_	_	_	_
17	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
18	augmentative	augmentative	ADJ	JJ	Degree=Pos	_	_	_	_
19	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3927
# text = We now show that the core contains a single critical c-Myb binding site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	core	core	NOUN	NN	Number=Sing	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
10	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3928
# text = In both transiently cotransfected human cells and stable chromatin-integrated yeast cells, c-Myb strongly transactivated reporter constructs that contained polymerized core sequences.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	transiently	transiently	ADV	RB	_	_	_	_	_
4	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
9	chromatin-	chromatin-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	integrated	integrate	ADJ	JJ	Degree=Pos	_	_	_	_
11	yeast	yeast	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
16	strongly	strongly	ADV	RB	_	_	_	_	_
17	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	polymerized	polymerize	ADJ	JJ	Degree=Pos	_	_	_	_
23	core	core	NOUN	NN	Number=Sing	_	_	_	_
24	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3929
# text = c-Myb protein was strongly evident in T lymphoblasts in which the enhancer was active and was localized within discrete nuclear structures.
1	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	strongly	strongly	ADV	RB	_	_	_	_	_
6	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphoblasts	lymphoblast	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=1|Tense=Past|VerbForm=Fin	_	_	_	_
18	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	structures	structure	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3930
# text = Fetal murine thymus exhibited a striking concordance of endogenous c-myb expression with that of mouse ADA and human ADA LCR-directed transgene expression.
1	Fetal	Fetal	ADJ	JJ	Degree=Pos	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
4	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	striking	strik	NOUN	NN	Number=Sing	_	_	_	_
7	concordance	concordance	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
10	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
17	ADA	ada	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	ADA	Ada	PROPN	NNP	Number=Sing	_	_	_	_
21	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transgene	transgene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3931
# text = Point mutation of the c-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in transgenic thymocytes.
1	Point	point	NOUN	NN	Number=Sing	_	_	_	_
2	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
12	2.3	2.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
15	LCR	LCR	X	GW	_	_	_	_	_
16	severely	severely	ADV	RB	_	_	_	_	_
17	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	transfections	transfection	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	LCR	Lcr	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
27	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3932
# text = Within the context of a complex enhancer and LCR, c-Myb can act as an organizer of thymocyte-specific gene expression via a single binding site.
1	Within	within	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	context	context	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	LCR	Lcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	organizer	organizer	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thymocyte	thymocyte	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
27	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3933
# text = Document 003003609 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003609	003003609	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3934
# text = [Hormonal metabolic status in breast cancer patients after conservative surgery: comparison with known prognostic criteria]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Hormonal	Hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
3	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
4	status	status	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
7	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	conservative	conservative	ADJ	JJ	Degree=Pos	_	_	_	_
11	surgery	surgery	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	prognostic	prognostic	ADJ	JJ	Degree=Pos	_	_	_	_
17	criteria	criteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3935
# text = Body weight, body mass index, body fat, lean body mass, blood-glucose, cholesterol, HDL-cholesterol, triglyceride, beta-lipoproteins, insulin, gonadotropin, estradiol, testosterone, SHBG, T3, T4 and TSH levels as well as estradiol and progesterone receptor levels in excised tumor were studied in 40 patients with breast cancer prior to conservative treatment.
1	Body	Body	NOUN	NN	Number=Sing	_	_	_	_
2	weight	weight	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	body	body	NOUN	NN	Number=Sing	_	_	_	_
5	mass	mass	ADJ	JJ	Degree=Pos	_	_	_	_
6	index	index	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	body	body	NOUN	NN	Number=Sing	_	_	_	_
9	fat	fat	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	lean	lean	ADJ	JJ	Degree=Pos	_	_	_	_
12	body	body	NOUN	NN	Number=Sing	_	_	_	_
13	mass	mass	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	glucose	glucose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	HDL	Hdl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	triglyceride	triglyceride	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	insulin	insulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	gonadotropin	gonadotropin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	testosterone	testosterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	SHBG	SHBG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	T3	T3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	T4	T4	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	TSH	Tsh	NOUN	NN	Number=Sing	_	_	_	_
46	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
47	as	as	ADV	RB	_	_	_	_	_
48	well	well	ADV	RB	Degree=Pos	_	_	_	_
49	as	as	ADP	IN	_	_	_	_	_
50	estradiol	estradiol	ADJ	JJ	Degree=Pos	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
53	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
54	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	excised	excised	ADJ	JJ	Degree=Pos	_	_	_	_
57	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
58	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
59	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
60	in	in	ADP	IN	_	_	_	_	_
61	40	40	NUM	CD	NumType=Card	_	_	_	_
62	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
63	with	with	ADP	IN	_	_	_	_	_
64	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
65	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
66	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
67	to	to	ADP	IN	_	_	_	_	_
68	conservative	conservative	ADJ	JJ	Degree=Pos	_	_	_	_
69	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3936
# text = Said anthropometric, metabolic and hormonal parameters were compared with the index of lymphocytic infiltration of tumor selected as a prognostic factor.
1	Said	say	ADJ	JJ	Degree=Pos	_	_	_	_
2	anthropometric	anthropometric	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
7	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	index	index	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	prognostic	prognostic	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3937
# text = A significant correlation between high lymphocytic infiltration (2.5 points), low body mass and fat was identified.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	2.5	2.5	NUM	CD	NumType=Card	_	_	_	_
10	points	point	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	body	body	NOUN	NN	Number=Sing	_	_	_	_
15	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	fat	fat	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3938
# text = Also, smoking contributed to loss of body mass and fat; however, it caused lymphocytic infiltration to rise.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	smoking	smok	NOUN	NN	Number=Sing	_	_	_	_
4	contributed	contribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	loss	loss	VERB	VB	VerbForm=Inf	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	body	body	NOUN	NN	Number=Sing	_	_	_	_
9	mass	mass	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	fat	fat	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	rise	rise	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3939
# text = Moderate body mass, relatively low fat level and positive receptor status are among factors of good prognosis in breast cancer of early stages.
1	Moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
2	body	body	NOUN	NN	Number=Sing	_	_	_	_
3	mass	mass	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	relatively	relatively	ADV	RB	_	_	_	_	_
6	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
7	fat	fat	ADJ	JJ	Degree=Pos	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	status	status	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	among	among	ADP	IN	_	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	good	good	ADJ	JJ	Degree=Pos	_	_	_	_
18	prognosis	prognosis	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
21	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
24	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3940
# text = Document 003003610 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003610	003003610	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3941
# text = FK506 and ciclosporin: molecular probes for studying intracellular signal transduction.
1	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	ciclosporin	ciclosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3942
# text = The immunosuppressants ciclosporin and FK506 block the Ca(2+)-dependent signal-transduction pathway emanating from the T-cell receptor, thereby inhibiting the activation of helper T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
3	ciclosporin	ciclosporin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
6	block	block	NOUN	NN	Number=Sing	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
18	emanating	emanat	VERB	VBG	VerbForm=Ger	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	thereby	thereby	ADV	RB	_	_	_	_	_
26	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3943
# text = Using these drugs as probes, chemists and biologists have uncovered several intracellular signalling molecules bridging the generation of second-messenger Ca2+ ions and the transcriptional activation of IL-2, among which are calmodulin, calcineurin and the nuclear factor of activated T cells (NF-AT).
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	probes	probe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	chemists	chemist	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	biologists	biologist	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	uncovered	uncover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
16	bridging	bridge	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
23	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	+	+	SYM	SYM	_	_	_	_	_
25	ions	ion	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	among	among	ADP	IN	_	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	calmodulin	calmodulin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3944
# text = Hence, Ca2+ binds to calmodulin, leading to the binding of calmodulin to calcineurin; the activated calcineurin, in turn, may dephosphorylate the cytoplasmic subunit of NF-AT, resulting in its translocation from the cytoplasm into the nucleus to form a competent transcriptional activator.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	_
5	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	calmodulin	calmodulin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	calmodulin	calmodulin	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	calcineurin	calcineurin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	dephosphorylate	dephosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
29	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
42	into	into	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
47	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	competent	competent	ADJ	JJ	Degree=Pos	_	_	_	_
49	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
50	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3945
# text = As described by Jun Liu, these drugs manifest their effects in an unprecedented fashion.
1	As	as	SCONJ	IN	_	_	_	_	_
2	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
5	Liu	Liu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
9	manifest	manifest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	unprecedented	unprecedented	ADJ	JJ	Degree=Pos	_	_	_	_
15	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3946
# text = They do not directly intercept intracellular signalling molecules.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	directly	directly	ADV	RB	_	_	_	_	_
5	intercept	intercept	VERB	VB	VerbForm=Inf	_	_	_	_
6	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
7	signalling	signall	NOUN	NN	Number=Sing	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3947
# text = Instead, they form tight complexes with two different classes of abundant cytosolic receptors called immunophilins upon entering the cell, and consequently inhibit their peptidyl prolyl cis-trans isomerase activities.
1	Instead	instead	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
4	form	form	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
6	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
15	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	immunophilins	immunophilin	NOUN	NNS	Number=Plur	_	_	_	_
17	upon	upon	SCONJ	IN	_	_	_	_	_
18	entering	enter	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	consequently	consequently	ADV	RB	_	_	_	_	_
24	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	peptidyl	peptidyl	NOUN	NN	Number=Sing	_	_	_	_
27	prolyl	prolyl	NOUN	NN	Number=Sing	_	_	_	_
28	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
31	isomerase	isomerase	NOUN	NN	Number=Sing	_	_	_	_
32	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3948
# text = The two structurally distinct immunophilin-drug complexes bind to, and inhibit, the phosphatase activity of calcineurin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	structurally	structurally	ADV	RB	_	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunophilin	immunophilin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
8	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
9	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3949
# text = Document 003003613 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003613	003003613	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3950
# text = Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates
1	Latent	Latent	ADJ	JJ	Degree=Pos	_	_	_	_
2	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_

# sent_id = 3951
# text = STAT proteins.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3952
# text = Latent membrane protein 1 (LMP1) acts like a permanently activated receptor of the tumor necrosis factor (TNF)-receptor superfamily and is absolutely required for B cell immortalization by Epstein-Barr virus.
1	Latent	Latent	ADJ	JJ	Degree=Pos	_	_	_	_
2	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	like	like	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	permanently	permanently	ADV	RB	_	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
17	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	superfamily	superfamily	ADV	RB	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	absolutely	absolutely	ADV	RB	_	_	_	_	_
28	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
37	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3953
# text = Molecular and biochemical approaches demonstrated that LMP1 usurps cellular signaling pathways resulting in the induction of NF-kappaB and AP-1 via two C-terminal activating regions.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
4	approaches	approach	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
8	usurps	usurp	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
10	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
11	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
12	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
28	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3954
# text = We demonstrate here that a third region encompassing a proline rich sequence within the 33 bp repetitive stretch of LMP1's C-terminus is required for the activation of Janus kinase 3 (JAK3).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	proline	proline	NOUN	NN	Number=Sing	_	_	_	_
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	33	33	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	repetitive	repetitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	stretch	stretch	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	1's	1'	PART	POS	_	_	_	_	_
22	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	3	3	NUM	CD	NumType=Card	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3955
# text = The interaction of LMP1 and JAK3
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 3956
# text = leads to the enhanced tyrosine auto/transphosphorylation of JAK3 within minutes after crosslinking of a conditional NGF-R:LMP1 chimera and is a prerequisite for the activation of STAT transcription factors.
1	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	auto	auto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	transphosphorylation	transphosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
13	after	after	SCONJ	IN	_	_	_	_	_
14	crosslinking	crosslinking	VERB	VBG	VerbForm=Ger	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
18	NGF	NGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-R:LMP1	-R:LMP1	NUM	CD	NumType=Card	_	_	_	_
20	chimera	chimera	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	prerequisite	prerequisite	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3957
# text = These results reveal a novel activating region in the LMP1 C-terminus and identify the JAK/STAT pathway as a target of this viral integral membrane protein in B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
11	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	target	target	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	integral	integral	ADJ	JJ	Degree=Pos	_	_	_	_
28	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3958
# text = Document 003003614 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003614	003003614	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3959
# text = Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	SCID	Scid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
16	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3960
# text = Males with X-linked severe combined immunodeficiency (XSCID) have defects in the common cytokine receptor gamma chain (gamma c) gene that encodes a shared, essential component of the receptors of interleukin-2 (IL-2), IL-4, IL-7, IL-9, and IL-15.
1	Males	male	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
7	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	XSCID	XSCID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
32	component	component	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
61	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3961
# text = The Janus family tyrosine kinase Jak3 is the only signaling molecule known to be associated with gamma c, so it was hypothesized that defects in Jak3 might cause an XSCID-like phenotype.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
12	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	so	so	ADV	RB	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	hypothesized	hypothesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
28	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
29	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	XSCID	XSCID	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
34	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3962
# text = A girl with immunological features indistinguishable from those of XSCID was therefore selected for analysis.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	girl	girl	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
5	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
6	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	XSCID	XSCID	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	therefore	therefore	ADV	RB	_	_	_	_	_
13	selected	select	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3963
# text = An Epstein-Barr virus (EBV)-transformed cell line derived from her lymphocytes had normal gamma c expression but lacked Jak3 protein and had greatly diminished Jak3 messenger RNA.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	her	she	PRON	PRP$	Gender=Fem|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	greatly	greatly	ADV	RB	_	_	_	_	_
29	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
31	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
32	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3964
# text = Sequencing revealed a different mutation on each allele: a single nucleotide insertion resulting in a frame shift and premature termination in the Jak3 JH4 domain and a nonsense mutation in the Jak3 JH2 domain.
1	Sequencing	Sequencing	PROPN	NNP	Number=Sing	_	_	_	_
2	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	each	each	DET	DT	_	_	_	_	_
8	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
12	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
13	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
14	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
18	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	premature	premature	ADJ	JJ	Degree=Pos	_	_	_	_
21	termination	termination	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
25	JH4	JH4	NUM	CD	NumType=Card	_	_	_	_
26	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	nonsense	nonsense	NOUN	NN	Number=Sing	_	_	_	_
30	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
34	JH2	JH2	NUM	CD	NumType=Card	_	_	_	_
35	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3965
# text = The lack of Jak3 expression correlated with impaired B cell signaling, as demonstrated by the inability of IL-4 to activate Stat6 in the EBV-transformed cell line from the patient.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
24	Stat6	stat6	NUM	CD	NumType=Card	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3966
# text = These observations indicate that the functions of gamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	development	development	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3967
# text = Document 003003618 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003618	003003618	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3968
# text = Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate.
1	Minimally	Minimally	ADV	RB	_	_	_	_	_
2	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
4	density	density	NOUN	NN	Number=Sing	_	_	_	_
5	lipoprotein-induced	lipoprotein-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
15	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
16	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3969
# text = We have previously shown that minimally oxidized LDL (MM-LDL) activated endothelial cells to increase their interaction with monocytes but not neutrophils, inducing monocyte but not neutrophil binding and synthesis of monocyte chemotactic protein-1 and monocyte colony-stimulating factor (M-CSF).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	minimally	minimally	ADV	RB	_	_	_	_	_
7	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
28	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	ADV	RB	_	_	_	_	_
31	neutrophil	neutrophil	SCONJ	IN	_	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
37	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
43	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
46	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3970
# text = In the present studies we have examined the signaling pathways by which this monocyte-specific response is induced.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3971
# text = Both induction of monocyte binding and mRNA levels for M-CSF by MM-LDL were not inhibited in protein kinase C-depleted endothelial cells.
1	Both	both	DET	DT	_	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	mRNA	mRNa	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3972
# text = A number of our studies indicate that cAMP is the second messenger for the effects of MM-LDL cited above.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
12	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
20	cited	cite	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	above	above	ADV	RB	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3973
# text = Incubation of endothelial cells with MM-LDL caused a 173% increase in intracellular cAMP levels.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
9	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	173	173	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	%	%	SYM	NN	Number=Sing	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3974
# text = Agents which increased cAMP levels, including cholera toxin, pertussis toxin, dibutyryl cAMP, and isoproterenol mimicked the actions of MM-LDL. Agents which elevated cAMP were also shown to activate NF kappa B, suggesting a role for this transcription factor in activation of monocyte-endothelial interactions.
1	Agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
2	which	which	PRON	WDT	PronType=Rel	_	_	_	_
3	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
8	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
9	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	pertussis	pertussis	NOUN	NN	Number=Sing	_	_	_	_
12	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	dibutyryl	dibutyryl	NOUN	NN	Number=Sing	_	_	_	_
15	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	isoproterenol	isoproterenol	ADV	RB	_	_	_	_	_
19	mimicked	mimick	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	LDL.	LDL.	PROPN	NNP	Number=Sing	_	_	_	_
26	Agents	Agents	PROPN	NNPS	Number=Plur	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	elevated	elevate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	also	also	ADV	RB	_	_	_	_	_
32	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
35	NF	NF	ADP	RP	_	_	_	_	_
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	role	role	NOUN	NN	Number=Sing	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
52	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3975
# text = Although endothelial leukocyte adhesion molecule (ELAM) mRNA synthesis can be regulated by NF kappa B, ELAM was not expressed and ELAM mRNA was only slightly elevated in response to MM-LDL. We present evidence that induction of neutrophil binding by LPS is actually suppressed by agents that elevated cAMP levels.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ELAM	ELAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	ELAM	ELAM	PROPN	NNP	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	ELAM	ELAM	PROPN	NNP	Number=Sing	_	_	_	_
25	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	slightly	slightly	ADV	RB	_	_	_	_	_
29	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_
37	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
38	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
39	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
40	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
41	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	neutrophil	neutrophil	SCONJ	IN	_	_	_	_	_
44	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
47	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	actually	actually	ADV	RB	_	_	_	_	_
49	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
52	that	that	PRON	WDT	PronType=Rel	_	_	_	_
53	elevated	elevate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
54	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
55	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3976
# text = Document 003003620 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003620	003003620	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3977
# text = The role of shared receptor motifs and common
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	common	common	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3978
# text = Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.
1	Stat	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	pleiotropy	pleiotropy	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	redundancy	redundancy	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-7	-7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3979
# text = To understand the molecular bases for cytokine redundancy and pleiotropy, we have compared the Stat proteins activated in peripheral blood lymphocytes (PBLs) by cytokines with shared and distinct actions.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	bases	basis	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	redundancy	redundancy	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	pleiotropy	pleiotropy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
21	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	PBLs	PBL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	shared	share	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
32	actions	action	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3980
# text = Interleukin-2 (IL-2) rapidly activated Stat5 in fresh PBL, and Stat3 and Stat5 in preactivated PBL.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	rapidly	rapidly	ADV	RB	_	_	_	_	_
10	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
14	PBL	PBL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	preactivated	preactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3981
# text = IL-7 and IL-15 induced the same complexes as IL-2, a feature explained by the existence of similar tyrosine-phosphorylated motifs in the cytoplasmic domains of IL-2R beta and IL-7R that can serve as docking sites for
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	15	15	NUM	CD	NumType=Card	_	_	_	_
8	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
11	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
19	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
32	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
37	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	7R	7r	PROPN	NNP	Number=Sing	_	_	_	_
42	that	that	PRON	WDT	PronType=Rel	_	_	_	_
43	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
44	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
45	as	as	SCONJ	IN	_	_	_	_	_
46	docking	docke	VERB	VBG	VerbForm=Ger	_	_	_	_
47	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
48	for	for	ADP	IN	_	_	_	_	_

# sent_id = 3982
# text = Stat proteins.
1	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3983
# text = IL-13
1	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-13	-13	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 3984
# text = Induced the same complexes as IL-4, a finding explained by our studies implicating IL-4R as a shared component of the receptors.
1	Induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
4	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
12	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
15	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
16	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4R	4R	PROPN	NNP	Number=Sing	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	component	component	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3985
# text = These studies demonstrate that a single cytokine can activate different combinations of Stat proteins under different physiological conditions, and also indicate two mechanisms by which distinct cytokines can activate the same Stat protein.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	under	under	ADP	IN	_	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
18	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	two	two	NUM	CD	NumType=Card	_	_	_	_
24	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
28	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
33	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3986
# text = Document 003003622 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003622	003003622	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3987
# text = Identification of essential GATA and Ets binding motifs within the promoter of the platelet glycoprotein
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
15	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3988
# text = Ib alpha gene.
1	Ib	Ib	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	alpha	alpha	ADP	IN	_	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3989
# text = Platelet glycoprotein (GP) Ib-IX-V is a multisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	_
2	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	GP	GP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	Ib	Ib	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	IX	IX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	V	V	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	multisubunit	multisubunit	NOUN	NN	Number=Sing	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
19	attachment	attachment	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	thrombogenic	thrombogenic	ADJ	JJ	Degree=Pos	_	_	_	_
22	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
27	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3990
# text = The congenital absence of the receptor results in a bleeding disorder associated with "giant" platelets, a condition linking the expression of the complex to platelet morphogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	congenital	congenital	ADJ	JJ	Degree=Pos	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	bleeding	bleeding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
15	giant	giant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	"	"	PUNCT	''	_	_	_	_	_
17	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	condition	condition	NOUN	NN	Number=Sing	_	_	_	_
21	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	platelet	platelet	VERB	VB	VerbForm=Inf	_	_	_	_
29	morphogenesis	morphogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3991
# text = To understand better the expression of the GP
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	better	better	ADV	RBR	Degree=Cmp	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	GP	GP	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3992
# text = Ib-IX-V complex, studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex (GP Ib alpha).
1	Ib	Ib	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	IX	IX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	V	V	PROPN	NNP	Number=Sing	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
15	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
16	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
17	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	GP	GP	PROPN	NNP	Number=Sing	_	_	_	_
30	Ib	Ib	PROPN	NNP	Number=Sing	_	_	_	_
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3993
# text = GP
1	GP	Gp	SYM	NFP	_	_	_	_	_

# sent_id = 3994
# text = Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme, luciferase.
1	Ib	Ib	X	LS	_	_	_	_	_
2	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
3	promoter	promoter	X	GW	_	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
16	coding	cod	VERB	VBG	VerbForm=Ger	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3995
# text = Studies were initiated with a fragment extending 2,738 nucleotides 5' to the transcription start site and lead to the identification of 253 nucleotides retaining full promoter activity in human erythroleukemia cells.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
7	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
8	2,738	2,738	NUM	CD	NumType=Card	_	_	_	_
9	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	start	start	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	253	253	NUM	CD	NumType=Card	_	_	_	_
24	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
25	retaining	retain	VERB	VBG	VerbForm=Ger	_	_	_	_
26	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3996
# text = In cells of nonhematopoietic lineage, human endothelial and HeLa cells, the GP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs.
1	In	in	ADP	IN	_	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nonhematopoietic	nonhematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	GP	GP	PROPN	NNP	Number=Sing	_	_	_	_
15	Ib	Ib	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	no	no	ADV	RB	_	_	_	_	_
21	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	background	background	NOUN	NN	Number=Sing	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	promoterless	promoterless	ADJ	JJ	Degree=Pos	_	_	_	_
28	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3997
# text = Gel shift assays and site-directed mutagenesis studies defined essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site, a finding which further substantiates these elements as important determinants of megakaryocytic gene expression.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
9	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
10	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
12	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
17	93	93	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	150	150	NUM	CD	NumType=Card	_	_	_	_
20	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
21	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	start	start	NOUN	NN	Number=Sing	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	further	further	ADV	RB	_	_	_	_	_
32	substantiates	substantiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
37	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3998
# text = The results define essential cis-acting elements responsible for the expression of GP Ib alpha and provide insights into molecular events coinciding with the release of normal platelets into the bloodstream.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
5	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GP	GP	PROPN	NNP	Number=Sing	_	_	_	_
14	Ib	Ib	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
18	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
19	into	into	ADP	IN	_	_	_	_	_
20	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
21	events	event	NOUN	NNS	Number=Plur	_	_	_	_
22	coinciding	coincide	VERB	VBG	VerbForm=Ger	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	release	release	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
28	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	bloodstream	bloodstream	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3999
# text = Document 003003623 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003623	003003623	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4000
# text = Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	interleukin	interleukin	ADV	RB	_	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NFkappaB	Nfkappab	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	NFkappaB	Nfkappab	ADV	RB	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4001
# text = In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene.
1	In	in	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
12	state	state	NOUN	NN	Number=Sing	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	predominantly	predominantly	ADV	RB	_	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	result	result	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4002
# text = Expression of interleukin 1beta and other cytokines, such as interleukin 6 and tumor necrosis factor alpha, has been shown to be dependent on the activation of the transcription factor, NFkappaB.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
16	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4003
# text = Since recent studies have shown that lipopolysaccharide-induced tyrosine kinase activation is not required for NFkappaB nuclear translocation, we sought to determine whether NFkappaB translocated in the absence of tyrosine kinase activity was active in stimulating transcription.
1	Since	since	ADP	IN	_	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
25	whether	whether	SCONJ	IN	_	_	_	_	_
26	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
27	translocated	translocate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
33	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
37	in	in	SCONJ	IN	_	_	_	_	_
38	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4004
# text = We have found that, in the human pro-monocytic cell line, THP-1, the lipopolysaccharide-induced expression of interleukin 1beta is dependent on tyrosine kinase activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	pro-monocytic	pro-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4005
# text = Tyrosine kinases are not required for lipopolysaccharide-mediated nuclear translocation of NFkappaB.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4006
# text = However, in the absence of tyrosine kinase activity, the ability of NFkappaB to stimulate transcription is impaired.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4007
# text = This inhibition of transcription is specific for NFkappaB; in the absence of tyrosine kinase activity, AP-1-dependent transcription is enhanced.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	;	;	PUNCT	,	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4008
# text = These results suggest that, while lipopolysaccharide-induced expression of inflammatory mediators requires tyrosine kinase activity, tyrosine kinase activity is not obligatory for lipopolysaccharide signal transduction.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	while	while	SCONJ	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
14	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	obligatory	obligatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
27	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
28	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4009
# text = Document 003003626 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003626	003003626	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4010
# text = Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.
1	Cleavage	Cleavage	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	SP1	Sp1	NUM	CD	NumType=Card	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	caspases	caspase	NOUN	NNS	Number=Plur	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	anti-IgM	anti-IgM	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4011
# text = Apoptosis is instrumental in the processes generating the diversity of the B-cell repertoire.
1	Apoptosis	Apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	instrumental	instrumental	ADJ	JJ	Degree=Pos	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	processes	processe	NOUN	NNS	Number=Plur	_	_	_	_
7	generating	generate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	diversity	diversity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	repertoire	repertoire	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4012
# text = Autoreactive B-cells are eliminated by anti-IgM crosslinking after encountering self-antigens, but precise mechanisms leading to B-cell apoptosis are still not well understood.
1	Autoreactive	Autoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	eliminated	eliminate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
9	-IgM	-Igm	ADJ	JJ	Degree=Pos	_	_	_	_
10	crosslinking	crosslink	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	SCONJ	IN	_	_	_	_	_
12	encountering	encounter	VERB	VBG	VerbForm=Ger	_	_	_	_
13	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
20	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	still	still	ADV	RB	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4013
# text = We report here the cleavage of the transcription factor SP1 in the human Burkitt lymphoma cell line BL60 during anti-IgM-induced apoptosis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	BL60	BL60	NUM	CD	NumType=Card	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	anti-IgM	anti-IgM	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	ADJ	JJ	Degree=Pos	_	_	_	_
23	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4014
# text = Western blot analysis revealed two cleavage products of approximately 68 kDa and 45 kDa after induction of apoptosis.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	approximately	approximately	ADV	RB	_	_	_	_	_
10	68	68	NUM	CD	NumType=Card	_	_	_	_
11	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	45	45	NUM	CD	NumType=Card	_	_	_	_
14	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4015
# text = Cleavage could be completely inhibited by zDEVD-fmk, an inhibitor specific for caspase 3-like proteases.
1	Cleavage	Cleavage	NOUN	NN	Number=Sing	_	_	_	_
2	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	completely	completely	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	zDEVD	zdevd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	like	like	ADP	IN	_	_	_	_	_
19	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4016
# text = In-vitro cleavage of recombinant SP1 by recombinant caspase 3 (CPP32) or caspase 7 (Mch 3) results in similar cleavage products as those observed in vivo.
1	In	in	ADP	IN	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
4	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
7	SP1	Sp1	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
10	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CPP32	Cpp32	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
17	7	7	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	Mch	Mch	NOUN	NN	Number=Sing	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	results	result	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
25	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
26	products	product	NOUN	NNS	Number=Plur	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
29	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4017
# text = Recombinant caspase 6 (Mch 2) primarily generates a 68-kDa cleavage product, as observed after calcium ionophore (CaI) induced B-cell apoptosis.
1	Recombinant	Recombinant	NOUN	NN	Number=Sing	_	_	_	_
2	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	Mch	Mch	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	primarily	primarily	ADV	RB	_	_	_	_	_
9	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	68	68	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
14	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
15	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
21	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CaI	CaI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4018
# text = In contrast, caspase 1 (ICE) did not cleave SP1 in vitro.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ICE	ice	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	cleave	cleave	VERB	VB	VerbForm=Inf	_	_	_	_
12	SP1	Sp1	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4019
# text = The time course of SP1 cleavage during anti-IgM-induced apoptosis is paralleled by an increase of caspase activity measured by DEVD-p-nitroanilide (DEVD-pNA) cleavage.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	time	time	NOUN	NN	Number=Sing	_	_	_	_
3	course	course	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
6	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	anti-IgM	anti-IgM	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	DEVD	DEVD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	p-nitroanilide	p-nitroanilide	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	DEVD	Devd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	pNA	pNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4020
# text = DNA band-shift assays revealed a decrease in the intensity of the full length SP1/DNA complex and an increase in the intensity of a smaller complex due to the binding of one SP1 cleavage product.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	band	band	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
15	length	length	NOUN	NN	Number=Sing	_	_	_	_
16	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	smaller	smaller	ADJ	JJR	Degree=Cmp	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
30	due	due	ADP	IN	_	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	one	one	NUM	CD	NumType=Card	_	_	_	_
36	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
37	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
38	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4021
# text = By Edman sequencing we could identify a caspase 3 cleavage site after Asp584 (D584AQPQAGR), generating a 22-kDa C-terminal SP1 protein fragment which still contains the DNA binding site.
1	By	by	ADP	IN	_	_	_	_	_
2	Edman	Edman	PROPN	NNP	Number=Sing	_	_	_	_
3	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	Asp584	Asp584	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	D584AQPQAGR	D584AQPQAGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	generating	generate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	22	22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
23	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
25	SP1	Sp1	NUM	CD	NumType=Card	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	still	still	ADV	RB	_	_	_	_	_
30	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4022
# text = Our results show the cleavage of the human transcription factor SP1 in vivo and in vitro, underlining the central role of caspase 3-like proteases during the process of anti-IgM-induced apoptosis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	SP1	Sp1	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	underlining	underlin	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	like	like	SCONJ	IN	_	_	_	_	_
27	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
28	during	during	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	process	process	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	anti-IgM	anti-IgM	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4023
# text = Document 003003640 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003640	003003640	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4024
# text = [Effect of the regimen of kidney-tonifying and qi-invigorating on aging changes of glucocorticoid receptor]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Effect	effect	PROPN	NNP	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regimen	regiman	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	tonifying	tonifying	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	qi	qi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-invigorating	-invigorat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	on	on	SCONJ	IN	_	_	_	_	_
14	aging	ag	VERB	VBG	VerbForm=Ger	_	_	_	_
15	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4025
# text = The plasma cortisol concentration and the sites of glucocorticoid receptor (GCR) in the peripheral lymphocytes were measured in 32 healthy aged persons and 13 young adults.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
3	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
4	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	32	32	NUM	CD	NumType=Card	_	_	_	_
22	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
23	aged	age	ADJ	JJ	Degree=Pos	_	_	_	_
24	persons	person	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	13	13	NUM	CD	NumType=Card	_	_	_	_
27	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
28	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4026
# text = In animal experiment, GCR of spleen lymphocytic cell was also measured in 18 aged rats and 9 young rats.
1	In	in	ADP	IN	_	_	_	_	_
2	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
3	experiment	experiment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	GCR	Gcr	ADP	IN	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	spleen	spleen	NUM	CD	NumType=Card	_	_	_	_
8	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	18	18	NUM	CD	NumType=Card	_	_	_	_
15	aged	aged	ADJ	JJ	Degree=Pos	_	_	_	_
16	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	9	9	NUM	CD	NumType=Card	_	_	_	_
19	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
20	rats	rat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4027
# text = The results showed that GCR was significantly lower in the aged persons or rats than that in the young while the plasma cortisol level didn't change with aging.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	significantly	significantly	ADV	RB	_	_	_	_	_
8	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	aged	aged	ADJ	JJ	Degree=Pos	_	_	_	_
12	persons	person	NOUN	NNS	Number=Plur	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
15	than	than	ADP	IN	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	young	young	NOUN	NNS	Number=Plur	_	_	_	_
20	while	while	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
23	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
26	n't	not	PART	RB	_	_	_	_	_
27	change	change	VERB	VB	VerbForm=Inf	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4028
# text = So we think that GCR is more sensitive than the plasma cortisol level to reflect the aging change of the adrenal cortex function.
1	So	so	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	think	think	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
9	than	than	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
12	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	reflect	reflect	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	aging	ag	VERB	VBG	VerbForm=Ger	_	_	_	_
18	change	change	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
22	cortex	cortex	NOUN	NN	Number=Sing	_	_	_	_
23	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4029
# text = After the treatment with the regimen of Kidney-tonifying and Qi-invigorating, the GCR of the aged persons and rats was enhanced, and in this way, the function of the aged adrenal cortex was improved.
1	After	after	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	regimen	regimen	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Kidney	kidney	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	tonifying	tonify	VERB	VBG	VerbForm=Ger	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Qi-invigorating	Qi-invigorat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GCR	Gcr	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	aged	aged	ADJ	JJ	Degree=Pos	_	_	_	_
19	persons	person	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	way	way	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	function	function	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	aged	age	ADJ	JJ	Degree=Pos	_	_	_	_
35	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
36	cortex	cortex	NOUN	NN	Number=Sing	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	improved	improve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4030
# text = Document 003003645 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003645	003003645	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4031
# text = Immune functions, clinical parameters and hormone receptor status in breast cancer patients.
1	Immune	Immune	ADJ	JJ	Degree=Pos	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
5	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	status	status	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
12	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4032
# text = We have carried out a detailed analysis of the cellular immune functions of breast cancer patients in comparison with healthy controls.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	out	out	ADP	RP	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	detailed	detailed	ADJ	JJ	Degree=Pos	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
15	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
21	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4033
# text = A possible correlation between immune and clinical parameters was analysed in 50 breast cancer patients.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
8	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	50	50	NUM	CD	NumType=Card	_	_	_	_
13	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
14	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4034
# text = Immune parameters, natural killer cell and T lymphocyte functions and the numbers of circulating T lymphocytes were analysed against the clinical parameters comprising the tumour burden, the stage of the disease and the expression of hormone receptors on the tumour.
1	Immune	Immune	ADJ	JJ	Degree=Pos	_	_	_	_
2	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
5	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	T	t	NUM	CD	NumType=Card	_	_	_	_
9	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
10	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	SCONJ	IN	_	_	_	_	_
15	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	against	against	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
23	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
24	comprising	comprise	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
27	burden	burden	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	hormone	hormone	ADJ	JJ	Degree=Pos	_	_	_	_
39	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4035
# text = In order to analyse the immune function data effectively, low responders were identified with stringent cut-off values.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	analyse	analyse	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	data	data	NOUN	NN	Number=Sing	_	_	_	_
9	effectively	effectively	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	responders	responder	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	stringent	stringent	NOUN	NN	Number=Sing	_	_	_	_
17	cut	cut	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	off	off	ADP	RP	_	_	_	_	_
20	values	value	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4036
# text = Considerably higher proportions of low responders were found among the patient population.
1	Considerably	considerably	ADV	RB	_	_	_	_	_
2	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
3	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	responders	responder	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	among	among	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
12	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4037
# text = Elevated numbers of circulating T lymphocytes and CD3-directed cytolysis correlated with the expression of oestrogen receptors independently of the clinical/histological parameters.
1	Elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	SCONJ	IN	_	_	_	_	_
4	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cytolysis	cytolysis	NOUN	NN	Number=Sing	_	_	_	_
12	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	oestrogen	oestrogen	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
19	independently	independently	ADV	RB	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	histological	histological	ADJ	JJ	Degree=Pos	_	_	_	_
25	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4038
# text = Document 003003647 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003647	003003647	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4039
# text = Charybdotoxin-sensitive, Ca(2+)-dependent membrane potential changes are not involved in human T or B cell activation and proliferation.
1	Charybdotoxin	Charybdotoxin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
13	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
14	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4040
# text = The involvement of ion channels in B and T lymphocyte activation is supported by many reports of changes in ion fluxes and membrane potential after mitogen binding.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ion	ion	NOUN	NN	Number=Sing	_	_	_	_
5	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	supported	support	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
16	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	ion	ion	NOUN	NN	Number=Sing	_	_	_	_
21	fluxes	flux	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
24	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
25	after	after	ADP	IN	_	_	_	_	_
26	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4041
# text = Human T and B lymphocytes demonstrate an early and transient hyperpolarization after ligand binding.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
11	hyperpolarization	hyperpolarization	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4042
# text = Inasmuch as the change in membrane potential is dependent on elevation of free cytosolic calcium, the hyperpolarization is presumably through opening of Ca(2+)-stimulated K+ channels.
1	Inasmuch	Inasmuch	ADV	RB	_	_	_	_	_
2	as	as	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	change	change	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
7	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
15	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	hyperpolarization	hyperpolarization	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	presumably	presumably	ADV	RB	_	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	opening	opening	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	+	+	SYM	SYM	_	_	_	_	_
32	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4043
# text = We have used charybdotoxin, a known inhibitor of Ca(2+)-dependent K+ channels, to study the role of these channels in lymphocyte activation and mitogenesis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	charybdotoxin	charybdotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	K	k	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4044
# text = We demonstrate that charybdotoxin inhibits the ligand-induced transient membrane hyperpolarization in B and T cells in a dose-dependent fashion, without affecting changes in cytosolic Ca2+.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	charybdotoxin	charybdotoxin	NOUN	NN	Number=Sing	_	_	_	_
5	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
11	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
12	hyperpolarization	hyperpolarization	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	without	without	SCONJ	IN	_	_	_	_	_
26	affecting	affecte	VERB	VBG	VerbForm=Ger	_	_	_	_
27	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
30	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	+.	+.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4045
# text = However, blockade of the Ca(2+)-activated K+ channel is not associated with changes in cell-cycle gene activation, IL-2 production, IL-2R expression or B and T cell mitogenesis.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	channel	channel	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2R	2R	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	T	t	NUM	CD	NumType=Card	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4046
# text = These results imply that membrane potential changes secondary to the ligand-dependent opening of Ca(2+)-activated K+ channels are not involved in B and T lymphocyte activation and mitogenesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	membrane	membrane	ADJ	JJ	Degree=Pos	_	_	_	_
6	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	opening	opening	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+	+	SYM	SYM	_	_	_	_	_
24	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4047
# text = Document 003003650 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003650	003003650	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4048
# text = Epstein-Barr virus nuclear antigen 2 and latent membrane protein independently transactivate p53 through induction of NF-kappaB activity.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
12	independently	independently	ADV	RB	_	_	_	_	_
13	transactivate	transactivate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	p53	p53	NUM	CD	NumType=Card	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4049
# text = B-cell immortalization by Epstein-Barr virus (EBV) is dependent on permanent control of the cellular processes which normally regulate cell division and apoptosis, functions possessed by p53 in a number of normal cell types.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
17	control	control	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	processes	processe	NOUN	NNS	Number=Plur	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	normally	normally	ADV	RB	_	_	_	_	_
24	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	division	division	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
31	possessed	possess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	number	number	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4050
# text = In studies initiated to evaluate relationships between EBV latent genes and p53, p53 levels were found to increase approximately 10-fold 4 to 5 days after EBV infection of purified resting human B cells; the induced p53 was transcriptionally active.
1	In	in	ADP	IN	_	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
6	relationships	relationship	NOUN	NNS	Number=Plur	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
9	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	p53	p53	NUM	CD	NumType=Card	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
20	approximately	approximately	ADV	RB	_	_	_	_	_
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	_
27	days	day	NOUN	NNS	Number=Plur	_	_	_	_
28	after	after	ADP	IN	_	_	_	_	_
29	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
30	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
43	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4051
# text = Latent membrane protein 1 and, to a lesser extent, EBV nuclear antigen 2 mediated the increase in p53 levels via activation of the NF-kappaB transcription factor.
1	Latent	Latent	ADJ	JJ	Degree=Pos	_	_	_	_
2	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
10	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	p53	p53	NUM	CD	NumType=Card	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4052
# text = Document 003003651 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003651	003003651	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4053
# text = Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.
1	Grf40	Grf40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	Grb2	Grb2	NUM	CD	NumType=Card	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
14	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	76	76	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	LAT	LAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4054
# text = We molecularly cloned a new Grb2 family member, named Grf40, containing the common SH3-SH2-SH3 motif.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	molecularly	molecularly	ADV	RB	_	_	_	_	_
3	cloned	clon	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	Grb2	grb2	NOUN	NN	Number=Sing	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	named	nam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	Grf40	Grf40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
16	SH3-SH2	Sh3-sh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	SH3	SH3	NOUN	NN	Number=Sing	_	_	_	_
19	motif.	motif.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4055
# text = Expression of Grf40 is predominant in hematopoietic cells, particularly T cells.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Grf40	Grf40	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	particularly	particularly	ADV	RB	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4056
# text = Grf40 binds to the SH2 domain-containing leukocyte protein of 76 kD (SLP-76) via its SH3 domain more tightly than Grb2.
1	Grf40	Grf40	NUM	CD	NumType=Card	_	_	_	_
2	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	76	76	NUM	CD	NumType=Card	_	_	_	_
13	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	76	76	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	SH3	SH3	NOUN	NN	Number=Sing	_	_	_	_
22	domain	domain	ADV	RB	_	_	_	_	_
23	more	more	ADV	RBR	_	_	_	_	_
24	tightly	tightly	ADV	RB	_	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	Grb2	Grb2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4057
# text = Incidentally, Grf40 binds to linker for activation of T cells (LAT) possibly via its SH2 domain.
1	Incidentally	Incidentally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Grf40	Grf40	PROPN	NNP	Number=Sing	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	linker	linker	VERB	VB	VerbForm=Inf	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LAT	LAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	possibly	possibly	ADV	RB	_	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4058
# text = Overexpression of wild-type Grf40 in Jurkat cells induced a significant increase of SLP-76-dependent interleukin (IL)-2 promoter and nuclear factor of activated T cell (NF-AT) activation upon T cell receptor (TCR) stimulation, whereas the COOH-terminal SH3-deleted Grf40 mutant lacked any recognizable increase in IL-2 promoter activity.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	Grf40	Grf40	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	SLP-76	SLP-76	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	upon	upon	ADP	IN	_	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	whereas	whereas	SCONJ	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	COOH	COOh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
51	SH3	SH3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	Grf40	Grf40	PROPN	NNP	Number=Sing	_	_	_	_
55	mutant	mutant	ADV	RB	_	_	_	_	_
56	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
57	any	any	DET	DT	_	_	_	_	_
58	recognizable	recognizable	ADJ	JJ	Degree=Pos	_	_	_	_
59	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
60	in	in	ADP	IN	_	_	_	_	_
61	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	2	2	NUM	CD	NumType=Card	_	_	_	_
64	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
65	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4059
# text = Furthermore, the SH2-deleted Grf40 mutant led to a marked inhibition of these regulatory activities, the effect of which is apparently stronger than that of the SH2-deleted Grb2 mutant.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Grf40	Grf40	PROPN	NNP	Number=Sing	_	_	_	_
8	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
9	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	apparently	apparently	ADV	RB	_	_	_	_	_
25	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	Grb2	grb2	NOUN	NN	Number=Sing	_	_	_	_
34	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4060
# text = Our data suggest that Grf40 is an adaptor molecule involved in TCR-mediated signaling through a more efficient interaction than Grb2 with SLP-76 and LAT.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Grf40	Grf40	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	more	more	ADV	RBR	_	_	_	_	_
19	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	than	than	ADP	IN	_	_	_	_	_
22	Grb2	grb2	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	76	76	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	LAT	Lat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4061
# text = Document 003003655 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003655	003003655	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4062
# text = Regulation of the human interleukin-2 gene by the alpha and beta isoforms of the glucocorticoid receptor.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4063
# text = The immunosuppressive effects of glucocorticoids are largely due to transcriptional inhibition of immunologically relevant genes, such as the interleukin-2 (IL-2) gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	largely	largely	ADV	RB	_	_	_	_	_
8	due	due	ADP	IN	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	immunologically	immunologically	ADV	RB	_	_	_	_	_
14	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4064
# text = These effects are mediated by the intracellular glucocorticoid receptor (GR).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4065
# text = In humans, alternative splicing of the GR precursor mRNA gives rise to two receptor isoforms, termed GRalpha and GRbeta.
1	In	in	ADP	IN	_	_	_	_	_
2	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
5	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
9	precursor	precursor	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	gives	give	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	GRalpha	GRalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	GRbeta	GRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4066
# text = We previously demonstrated that GRbeta could antagonize GRalpha-mediated transactivation of a glucocorticoid-responsive element (GRE)-driven reporter gene in COS-7 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GRbeta	GRbeta	PROPN	NNP	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	antagonize	antagonize	VERB	VB	VerbForm=Inf	_	_	_	_
8	GRalpha	GRalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	7	7	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4067
# text = The present study was designed to analyze the roles of the two GR isoforms on glucocorticoid-mediated transrepression of the IL-2 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	GR	Gr	ADJ	JJ	Degree=Pos	_	_	_	_
14	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	glucocorticoid	glucocorticoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	transrepression	transrepression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4068
# text = Using a recently developed transfection technique, we demonstrate that in primary human lymphocytes, stimulation of a 548 bp IL-2 promoter-luciferase reporter construct by phorbol ester and calcium ionophore is reversed by dexamethasone to a similar extent as in Jurkat T lymphoma cells transfected with a GRalpha expression vector.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
6	technique	technique	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	548	548	NUM	CD	NumType=Card	_	_	_	_
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
31	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
34	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
42	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
43	as	as	ADP	IN	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
46	T	t	PROPN	NNP	Number=Sing	_	_	_	_
47	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	with	with	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	GRalpha	GRalpha	PROPN	NNP	Number=Sing	_	_	_	_
53	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
54	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4069
# text = Transfection of a GRbeta expression vector alone did not result in IL-2 promoter repression in response to glucocorticoids.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	GRbeta	GRbeta	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
7	alone	alone	ADV	RB	_	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4070
# text = Furthermore, GRbeta did not antagonize the repressive effects of GRalpha on IL-2 promoter activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	GRbeta	GRbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	antagonize	antagonize	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	GRalpha	GRalpha	PROPN	NNP	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4071
# text = Surprisingly, overexpression of GRbeta in Jurkat cells did not cause significant inhibition of GRalpha-induced transactivation of a GRE-dependent luciferase reporter gene either.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GRbeta	GRbeta	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
12	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	GRalpha	GRalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	GRE	GRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	either	either	ADV	RB	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4072
# text = We conclude that the transrepressive effect of glucocorticoids on IL-2 gene transcription is exclusively mediated by GRalpha.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transrepressive	transrepressive	ADJ	JJ	Degree=Pos	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	exclusively	exclusively	ADV	RB	_	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	GRalpha	GRalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4073
# text = GRbeta can neither antagonize GRalpha-mediated transactivation nor transrepression in Jurkat cells, indicating a cell type-specific pattern of GRbeta-mediated antiglucocorticoid activity.
1	GRbeta	GRbeta	PROPN	NNP	Number=Sing	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	neither	neither	ADV	RB	_	_	_	_	_
4	antagonize	antagonize	VERB	VB	VerbForm=Inf	_	_	_	_
5	GRalpha	GRalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
9	nor	nor	CCONJ	CC	_	_	_	_	_
10	transrepression	transrepression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	GRbeta	GRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	antiglucocorticoid	antiglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4074
# text = Document 003003662 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003662	003003662	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4075
# text = HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3 [see comments]
1	HLA-DR	Hla-dr	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD33+	Cd33+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	CD56+	Cd56+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	CD16	CD16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
13	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	previously	previously	ADV	RB	_	_	_	_	_
20	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
21	form	form	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
25	potentially	potentially	ADV	RB	_	_	_	_	_
26	misdiagnosed	misdiagnose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	French	french	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	American-	American-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	British	british	ADJ	JJ	Degree=Pos	_	_	_	_
32	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
33	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
34	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	M3	M3	NOUN	NN	Number=Sing	_	_	_	_
37	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	see	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4076
# text = We have identified and characterized a previously unrecognized form of acute leukemia that shares features of both myeloid and natural killer (NK) cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	previously	previously	ADV	RB	_	_	_	_	_
8	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
9	form	form	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	shares	share	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
21	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4077
# text = From a consecutive series of 350 cases of adult de novo acute myeloid leukemia (AML), we identified 20 cases (6%) with a unique immunophenotype: CD33+, CD56+, CD11a+, CD13lo, CD15lo, CD34+/-, HLA-DR-, CD16-.
1	From	from	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	consecutive	consecutive	ADJ	JJ	Degree=Pos	_	_	_	_
4	series	series	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	350	350	NUM	CD	NumType=Card	_	_	_	_
7	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
10	de	de	X	FW	Foreign=Yes	_	_	_	_
11	novo	novo	ADV	RB	_	_	_	_	_
12	acute	acute	VERB	VB	VerbForm=Inf	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	AML	AML	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	20	20	NUM	CD	NumType=Card	_	_	_	_
22	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
30	immunophenotype	immunophenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	:	:	PUNCT	:	_	_	_	_	_
32	CD33+	Cd33+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	CD56+	Cd56+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	CD11a	CD11a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	CD13	CD13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	lo	lo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	CD15	CD15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	lo	lo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	CD34+/-,	Cd34+/-,	NOUN	NN	Number=Sing	_	_	_	_
46	HLA-	HLA-	PUNCT	:	_	_	_	_	SpaceAfter=No
47	DR	dr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	16-.	16-.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4078
# text = Multicolor flow cytometric assays confirmed the coexpression of myeloid (CD33, CD13, CD15) and NK cell-associated (CD56) antigens in each case, whereas reverse transcription polymerase chain reaction (RT-PCR) assays confirmed the identity of CD56 (neural cell adhesion molecule) in leukemic blasts.
1	Multicolor	Multicolor	PROPN	NNP	Number=Sing	_	_	_	_
2	flow	flow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cytometric	cytometric	ADJ	JJ	Degree=Pos	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	confirmed	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	CD33	CD33	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	CD13	CD13	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	CD15	CD15	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CD56	Cd56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	each	each	DET	DT	_	_	_	_	_
28	case	case	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	whereas	whereas	SCONJ	IN	_	_	_	_	_
31	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
34	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
35	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	RT-PCR	Rt-pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
40	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	CD56	Cd56	PROPN	NNP	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	neural	neural	ADJ	JJ	Degree=Pos	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
49	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
53	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4079
# text = Although two cases expressed CD4, no case expressed CD2, CD3, or CD8 and no case showed clonal rearrangement of genes encoding the T-cell receptor (TCR beta, gamma, delta).
1	Although	although	SCONJ	IN	_	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	case	case	NOUN	NN	Number=Sing	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	no	no	DET	DT	_	_	_	_	_
18	case	case	NOUN	NN	Number=Sing	_	_	_	_
19	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
21	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	delta	delta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4080
# text = Leukemic blasts in the majority of cases shared unique morphologic features (deeply invaginated nuclear membranes, scant cytoplasm with fine azurophilic granularity, and finely granular Sudan black B and myeloperoxidase cytochemical reactivity) that were remarkably similar to those of acute promyelocytic leukemia (APL); particularly the microgranular variant (FAB AML-M3v).
1	Leukemic	Leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
2	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
8	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
10	morphologic	morphologic	NOUN	NN	Number=Sing	_	_	_	_
11	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	deeply	deeply	ADV	RB	_	_	_	_	_
14	invaginated	invaginate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	scant	scant	ADJ	JJ	Degree=Pos	_	_	_	_
19	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	fine	fine	ADJ	JJ	Degree=Pos	_	_	_	_
22	azurophilic	azurophilic	ADJ	JJ	Degree=Pos	_	_	_	_
23	granularity	granularity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	finely	finely	ADV	RB	_	_	_	_	_
27	granular	granular	ADJ	JJ	Degree=Pos	_	_	_	_
28	Sudan	Sudan	PROPN	NNP	Number=Sing	_	_	_	_
29	black	black	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	myeloperoxidase	myeloperoxidase	ADJ	JJ	Degree=Pos	_	_	_	_
33	cytochemical	cytochemical	ADJ	JJ	Degree=Pos	_	_	_	_
34	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	that	that	PRON	WDT	PronType=Rel	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	remarkably	remarkably	ADV	RB	_	_	_	_	_
39	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
44	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
45	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	APL	Apl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	;	;	PUNCT	,	_	_	_	_	_
50	particularly	particularly	ADV	RB	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	microgranular	microgranular	ADJ	JJ	Degree=Pos	_	_	_	_
53	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	FAB	FAB	PROPN	NNP	Number=Sing	_	_	_	_
56	AML	aml	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	M3	M3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4081
# text = However, all 20 cases lacked the t(15;17) and 17 cases tested lacked the promyelocytic/retinoic acid receptor alpha (RAR alpha) fusion transcript in RT-PCR assays; 12 cases had 46,XX or 46,XY karyotypes, whereas 2 cases had abnormalities of chromosome 17q: 1 with del(17)(q25) and the other with t(11;17)(q23;q21) and the promyelocytic leukemia zinc finger/RAR alpha fusion transcript.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	20	20	NUM	CD	NumType=Card	_	_	_	_
5	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
6	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	15;17	15;17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	17	17	NUM	CD	NumType=Card	_	_	_	_
14	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
15	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
29	transcript	transcriep	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	_
34	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	12	12	NUM	CD	NumType=Card	_	_	_	_
37	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
38	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	46	46	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
41	XX	XX	PROPN	NNP	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	46	46	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
45	XY	Xy	NOUN	NN	Number=Sing	_	_	_	_
46	karyotypes	karyotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	whereas	wherea	SCONJ	IN	_	_	_	_	_
49	2	2	NUM	CD	NumType=Card	_	_	_	_
50	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
51	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
52	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
55	17q	17q	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	:	:	PUNCT	:	_	_	_	_	_
57	1	1	NUM	CD	NumType=Card	_	_	_	_
58	with	with	ADP	IN	_	_	_	_	_
59	del	del	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	q25	q25	X	LS	_	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
69	with	with	ADP	IN	_	_	_	_	_
70	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
71	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
72	11;17	11;17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
73	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
74	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
75	q23;q21	q23;q21	X	LS	_	_	_	_	SpaceAfter=No
76	)	)	PUNCT	-RRB-	_	_	_	_	_
77	and	and	CCONJ	CC	_	_	_	_	_
78	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
79	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
80	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
81	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
82	finger	finger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
84	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
85	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
86	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
87	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4082
# text = All cases tested (6/20), including the case with t(11;17), failed to differentiate in vitro in response to all-trans retinoic acid (ATRA), suggesting that these cases may account for some APLs that have not shown a clinical response to ATRA.
1	All	all	DET	DT	_	_	_	_	_
2	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	6/20	6/20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	case	case	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	11;17	11;17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	all	all	DET	DT	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
28	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
29	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	ATRA	Atra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	some	some	DET	DT	_	_	_	_	_
42	APLs	APL	NOUN	NNS	Number=Plur	_	_	_	_
43	that	that	PRON	WDT	PronType=Rel	_	_	_	_
44	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
49	response	response	NOUN	NN	Number=Sing	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4083
# text = Four of 6 cases tested showed functional NK cell-mediated cytotoxicity, suggesting a relationship between these unique CD33+, CD56+, CD16- acute leukemias and normal CD56+, CD16- NK precursor cells.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
5	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	showed	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
20	CD33+	Cd33+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	CD56+	Cd56+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CD16	CD16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
27	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
30	CD56+	Cd56+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	_
35	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
36	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4084
# text = Using a combination of panning and multiparameter flow cytometric sorting, we identified a normal CD56+, CD33+, CD16- counterpart cell at a frequency of 1% to 2% in the peripheral blood of healthy individuals.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	panning	panning	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	multiparameter	multiparameter	NOUN	NN	Number=Sing	_	_	_	_
8	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
9	cytometric	cytometric	NOUN	NN	Number=Sing	_	_	_	_
10	sorting	sorting	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	CD56+	Cd56+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	CD33+	Cd33+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	CD16	CD16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	_
22	counterpart	counterpart	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	%	%	SYM	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	%	%	SYM	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
36	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
39	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4085
# text = Our studies suggest that this form of acute leukemia may arise from transformation of a precursor cell common to both the myeloid and NK cell lineages; thus we propose the designation myeloid/NK acute leukemia.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
9	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	arise	arise	VERB	VB	VerbForm=Inf	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	thus	thus	ADV	RB	_	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	designation	designation	NOUN	NN	Number=Sing	_	_	_	_
33	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
36	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
37	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4086
# text = Recognition of this new leukemic entity will be important in distinguishing these ATRA-nonresponsive cases from ATRA-responsive true APL.
1	Recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
6	entity	entity	NOUN	NN	Number=Sing	_	_	_	_
7	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	distinguishing	distinguish	VERB	VBG	VerbForm=Ger	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	ATRA	Atra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	nonresponsive	nonresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
16	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
21	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
22	APL	Apl	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4087
# text = Document 003003667 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003667	003003667	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4088
# text = Single point estimation of glucocorticoid receptors in lymphocytes of normal subjects and of children under long term glucocorticoid treatment.
1	Single	single	ADJ	JJ	Degree=Pos	_	_	_	_
2	point	point	NOUN	NN	Number=Sing	_	_	_	_
3	estimation	estimation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	children	child	NOUN	NNS	Number=Plur	_	_	_	_
15	under	under	ADP	IN	_	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
17	term	term	NOUN	NN	Number=Sing	_	_	_	_
18	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4089
# text = A single point assay of glucocorticoid receptors (GR) in human lymphocytes based on the measurement of specific dexamethasone binding has been developed and compared with a common multi-point Scatchard analysis.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
3	point	point	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	measurement	measurement	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
30	multi-point	multi-point	ADJ	JJ	Degree=Pos	_	_	_	_
31	Scatchard	Scatchard	PROPN	NNP	Number=Sing	_	_	_	_
32	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4090
# text = The assay conditions-concentration of the ligand 20 nmol/l, incubation time 2 h and the cell count 2-6 mil.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
9	20	20	NUM	CD	NumType=Card	_	_	_	_
10	nmol	nmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	l	l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
15	time	time	NOUN	NN	Number=Sing	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	h	h	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	count	count	NOUN	NN	Number=Sing	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	_
25	mil.	mil.	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 4091
# text = cells/tube in the assay volume 0.25 ml were found to be optimal.
1	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	tube	tube	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
7	volume	volume	NOUN	NN	Number=Sing	_	_	_	_
8	0.25	0.25	NUM	CD	NumType=Card	_	_	_	_
9	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4092
# text = An attempt was also undertaken to use a cell harvester for the separation of cells from unbound ligand.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	attempt	attempt	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	use	use	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	harvester	harvester	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	separation	separation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	unbound	unbound	ADJ	JJ	Degree=Pos	_	_	_	_
18	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4093
# text = Though specifically bound dexamethasone measured by whole-cell assay and that using cell harvester correlated well, almost by one order lower values obtained with the latter method render it non-applicable for receptor quantitation.
1	Though	though	SCONJ	IN	_	_	_	_	_
2	specifically	specifically	ADV	RB	_	_	_	_	_
3	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
4	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
5	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	harvester	harvester	NOUN	NN	Number=Sing	_	_	_	_
16	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	almost	almost	ADV	RB	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	one	one	NUM	CD	NumType=Card	_	_	_	_
22	order	order	NOUN	NN	Number=Sing	_	_	_	_
23	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
24	values	value	NOUN	NNS	Number=Plur	_	_	_	_
25	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
29	method	method	NOUN	NN	Number=Sing	_	_	_	_
30	render	render	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
32	non-applicable	non-applicable	ADJ	JJ	Degree=Pos	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	quantitation	quantitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4094
# text = The results from 9 healthy volunteers (average GR concentration 7131 +/- 1256 sites/cell) correlated excellently with those obtained by the Scatchard analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	9	9	NUM	CD	NumType=Card	_	_	_	_
5	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
6	volunteers	volunteer	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	average	average	ADJ	JJ	Degree=Pos	_	_	_	_
9	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
10	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
11	7131	7131	NUM	CD	NumType=Card	_	_	_	_
12	+/-	+/-	SYM	SYM	_	_	_	_	_
13	1256	1256	NUM	CD	NumType=Card	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	/cell	/cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	excellently	excellently	ADV	RB	_	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
21	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Scatchard	Scatchard	PROPN	NNP	Number=Sing	_	_	_	_
25	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4095
# text = The single point assay has been also applied for determination of GH in 10 children treated with large doses of prednisone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
3	point	point	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	GH	GH	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	children	child	NOUN	NNS	Number=Plur	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
19	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	prednisone	prednisone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4096
# text = The average values from healthy volunteers did not differ significantly from those found in these children, though much broader range was found in patients.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	average	average	ADJ	JJ	Degree=Pos	_	_	_	_
3	values	value	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
6	volunteers	volunteer	NOUN	NNS	Number=Plur	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	children	child	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	though	though	ADV	RB	_	_	_	_	_
19	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
20	broader	broader	NOUN	NN	Number=Sing	_	_	_	_
21	range	range	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4097
# text = Document 003003670 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003670	003003670	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4098
# text = Interleukin 2 signaling involves the phosphorylation of Stat proteins.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
4	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4099
# text = One of the most important cytokines involved in immune response regulation is interleukin 2 (IL-2), a potent activator of the proliferation and function of T lymphocytes and natural killer cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	most	most	ADV	RBS	_	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	interleukin	interleukin	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
23	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
34	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4100
# text = The mechanisms by which the effects of IL-2 are propagated within cells are not understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	propagated	propagate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4101
# text = While the binding of IL-2 to its receptor was recently shown to lead to the activation of two kinases, Jak-1 and Jak-3, subsequent steps in the signaling pathway to the nucleus that lead to the activation of specific genes had not been characterized.
1	While	while	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
32	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
36	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
40	that	that	PRON	WDT	PronType=Rel	_	_	_	_
41	lead	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
48	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	not	not	PART	RB	_	_	_	_	_
50	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4102
# text = Since many cytokines that activate Jak kinases also lead to the tyrosine phosphorylation and activation of members of the Stat family of transcription factors, the ability of IL-2 to trigger
1	Since	since	SCONJ	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	members	member	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
21	family	family	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	trigger	trigger	ADJ	JJR	Degree=Cmp	_	_	_	_

# sent_id = 4103
# text = Stat phosphorylation was examined.
1	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4104
# text = Exposure of activated human T lymphocytes or of a natural killer cell line (NKL) to IL-2 leads to the phosphorylation of Stat1 alpha, Stat1 beta, and Stat3, as well as of two Stat-related proteins, p94 and p95. p94 and p95 share homology with Stat1 at the phosphorylation site and in the Src homology 2 (SH2) domain, but otherwise are immunologically distinct from Stat1.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
11	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NKL	NKL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
30	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	as	as	ADV	RB	_	_	_	_	_
36	well	well	ADV	RB	Degree=Pos	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	two	two	NUM	CD	NumType=Card	_	_	_	_
40	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
43	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	p94	p94	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	p95.	p95.	NOUN	NN	Number=Sing	_	_	_	_
48	p94	p94	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	p95	p95	NUM	CD	NumType=Card	_	_	_	_
51	share	share	NOUN	NN	Number=Sing	_	_	_	_
52	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
55	at	at	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
58	site	site	NOUN	NN	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	in	in	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	Src	Src	PROPN	NNP	Number=Sing	_	_	_	_
63	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
64	2	2	NUM	CD	NumType=Card	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	_
68	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	but	but	CCONJ	CC	_	_	_	_	_
71	otherwise	otherwise	ADV	RB	_	_	_	_	_
72	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
73	immunologically	immunologically	ADV	RB	_	_	_	_	_
74	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
75	from	from	ADP	IN	_	_	_	_	_
76	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4105
# text = These
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_

# sent_id = 4106
# text = Stat proteins were found to translocate to the nucleus and to bind to a specific DNA sequence.
1	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	translocate	translocate	VERB	VB	VerbForm=Inf	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4107
# text = These findings suggest a mechanism by which IL-2 binding to its receptor may activate specific genes involved in immune cell function.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4108
# text = Document 003003671 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003671	003003671	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4109
# text = Nuclear factor-90 of activated T-cells:
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-90	-90	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4110
# text = A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-stranded	-stranded	ADJ	JJ	Degree=Pos	_	_	_	_
15	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	PKR	PKR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4111
# text = NFAT transcription factors play a central role in initiating T-cell activation through the induction of immediate-early T-cell specific genes including interleukin-2 (IL-2).
1	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	initiating	initiat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4112
# text = NFAT transcription factors bind to a sequence in the IL-2 enhancer known as the antigen receptor response element 2 (ARRE-2).
1	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ARRE	Arre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4113
# text = Multiple proteins exhibiting ARRE-2 binding activity have been isolated, including a heterodimer from stimulated T-cell nuclear extracts consisting of Mr = 90 000 (NF90) and Mr = 45 000 (NF45) subunits.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	exhibiting	exhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
4	ARRE	Arre	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
22	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Mr	mr	PROPN	NNP	Number=Sing	_	_	_	_
25	=	=	SYM	SYM	_	_	_	_	_
26	90	90	NUM	CD	NumType=Card	_	_	_	_
27	000	000	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF90	NF90	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Mr	mr	PROPN	NNP	Number=Sing	_	_	_	_
33	=	=	SYM	SYM	_	_	_	_	_
34	45	45	NUM	CD	NumType=Card	_	_	_	_
35	000	000	NUM	CD	NumType=Card	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	NF45	Nf45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4114
# text = The subunits of this heterodimer have been cloned, and NF90 was found to encode a protein containing two domains that are predicted to form motifs capable of binding to double-stranded RNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NF90	NF90	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	encode	encode	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
26	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
27	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
28	of	of	SCONJ	IN	_	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4115
# text = Using in vitro translated polypeptides, we have demonstrated that NF90 specifically binds to double-stranded RNA.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
4	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	NF90	NF90	PROPN	NNP	Number=Sing	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	double	double	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4116
# text = Furthermore, NF90 was phosphorylated in a double-stranded RNA-dependent manner likely by the interferon-induced, double-stranded RNA-dependent protein kinase, PKR.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF90	NF90	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
15	likely	likely	ADV	RB	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	PKR	PKR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4117
# text = The NF90 protein was found to be expressed not only in T-cells, but also in nonimmune HeLa cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF90	NF90	NUM	CD	NumType=Card	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	nonimmune	nonimmune	ADJ	JJ	Degree=Pos	_	_	_	_
19	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4118
# text = In HeLa cells, the protein was almost exclusively localized to the ribosome salt wash fraction of cell lysates.
1	In	in	ADP	IN	_	_	_	_	_
2	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	almost	almost	ADV	RB	_	_	_	_	_
9	exclusively	exclusively	ADV	RB	_	_	_	_	_
10	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ribosome	ribosome	ADJ	JJ	Degree=Pos	_	_	_	_
14	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
15	wash	wash	NOUN	NN	Number=Sing	_	_	_	_
16	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4119
# text = Document 003003674 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003674	003003674	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4120
# text = Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor.
1	Prolactin	Prolactin	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	MGF	MGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4121
# text = The cell surface receptors for PRL and interleukin-2 (IL-2) are structurally distinct, but share regulatory tasks in T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
4	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	structurally	structurally	ADV	RB	_	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	tasks	task	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4122
# text = They can stimulate proliferation and activate transcription of over-lapping sets of genes of T cells.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
4	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	over	over	SCONJ	IN	_	_	_	_	SpaceAfter=No
10	-lapping	-lapp	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4123
# text = PRL and IL-2 receptor activation are both linked to the Jak/Stat (signal transducer and activator of transcription) pathway.
1	PRL	pRl	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	both	both	ADV	RB	_	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4124
# text = We investigated the ability of PRL and IL-2 to activate
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	PRL	pRl	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 4125
# text = Stat proteins in different T cell lines.
1	Stat	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4126
# text = The DNA binding specificities, the reactivities toward Stat-specific antisera, and the mol wt of IL-2- and PRL-induced DNA-binding proteins in Nb2 and C196 T cell lines were investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	reactivities	reactivity	NOUN	NNS	Number=Plur	_	_	_	_
8	toward	toward	ADP	IN	_	_	_	_	_
9	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	mol	mol	NOUN	NN	Number=Sing	_	_	_	_
17	wt	wt	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	Nb2	nb2	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	C196	C196	PROPN	NNP	Number=Sing	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4127
# text = A comparison with the Stat proteins induced by interferon-gamma, PRL, and IL-6 in T47D mammary tumor cells was made.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PRL	PRL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T47D	T47d	ADJ	JJ	Degree=Pos	_	_	_	_
21	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
22	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	made	make	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4128
# text = We found that these parameters were indistinguishable for one of the PRL- and IL-2-induced factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	one	one	NUM	CD	NumType=Card	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	PRL	pRl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4129
# text = A transcription factor closely related to mammary gland factor-Stat5 is rapidly activated upon interaction of IL-2 and PRL with their respective receptors.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	closely	closely	ADV	RB	_	_	_	_	_
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
8	gland	gland	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	rapidly	rapidly	ADV	RB	_	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	upon	upon	ADP	IN	_	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4130
# text = Activation of a second protein related to Stat1 was also observed.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4131
# text = Our results emphasize the role of PRL as a regulator of the immune response and indicate that the Stat factors mammary gland factor-Stat5 and Stat1 play a role in the regulation of gene expression during T cell development.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	emphasize	emphasize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
22	gland	gland	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
28	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	role	role	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	during	during	ADP	IN	_	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4132
# text = Document 003003682 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003682	003003682	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4133
# text = Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	children	child	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	_
13	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
14	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4134
# text = Pit-1 is a pituitary-specific transcription factor that binds to and transactivates promoters of growth hormone and prolactin genes.
1	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
19	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	prolactin	prolactin	NOUN	NN	Number=Sing	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4135
# text = In three unrelated Japanese children with combined pituitary hormone deficiency, we identified three point mutations in the Pit-1 gene, Pro24Leu, Arg143Gln, and Arg271Trp, located on the major transactivation region, POU-specific domain, and POU-homeodomain, respectively.
1	In	in	ADP	IN	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	unrelated	unrelated	ADJ	JJ	Degree=Pos	_	_	_	_
4	Japanese	japanese	ADJ	JJ	Degree=Pos	_	_	_	_
5	children	child	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	_
9	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
10	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	three	three	NUM	CD	NumType=Card	_	_	_	_
15	point	point	NOUN	NN	Number=Sing	_	_	_	_
16	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Pro24Leu	Pro24Leu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Arg143Gln	Arg143Gln	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Arg271	Arg271	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	Trp	Trp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	on	on	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
36	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	POU	POU	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
42	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	POU-	Pou-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4136
# text = Document 003003691 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003691	003003691	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4137
# text = Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	LEF	LEF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	nucleosome	nucleosome	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	assembled	assemble	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4138
# text = Lymphoid enhancer-binding factor 1 (LEF-1) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha (TCR alpha) enhancer in a context-restricted manner in T cells.
1	Lymphoid	Lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	LEF	Lef	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
16	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
17	group	group	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HMG	HMG	INTJ	UH	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	T	t	PROPN	NNP	Number=Sing	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4139
# text = In this paper we demonstrate that the distal region of the human immunodeficiency virus-1 (HIV-1) enhancer, which contains DNA-binding sites for LEF-1 and Ets-1, also provides a functional context for activation by LEF-1.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	also	also	ADV	RB	_	_	_	_	_
40	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
43	context	context	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4140
# text = First, we show that mutations in the LEF-1-binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells, and that LEF-1/GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo.
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	LEF	LEF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
29	T	T	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
37	GAL4	GAL4	PROPN	NNP	Number=Sing	_	_	_	_
38	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
39	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	GAL4	Gal4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	substituted	substitute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
48	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4141
# text = Second, recombinant LEF-1 is shown to activate HIV-1 transcription on chromatin-assembled DNA in vitro.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
4	LEF	LEF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	chromatin-	chromatin-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	assembled	assembled	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4142
# text = By using a nucleosome-assembly system derived from Drosophila embryos, we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or LEF-1 and Ets-1) supplemented with fractions containing the promoter-binding protein, Sp1.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	nucleosome	nucleosome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
7	system	system	NOUN	NN	Number=Sing	_	_	_	_
8	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
11	embryos	embryo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	packaging	packaging	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	into	into	ADP	IN	_	_	_	_	_
21	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
24	strongly	strongly	ADV	RB	_	_	_	_	_
25	represses	repress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	counteracted	counteract	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	efficiently	efficiently	ADV	RB	_	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	or	or	CCONJ	CC	_	_	_	_	_
48	LEF	LEF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	1	1	NUM	CD	NumType=Card	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	1	1	X	LS	_	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	_
56	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	with	with	ADP	IN	_	_	_	_	_
58	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
59	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
64	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	,	,	PUNCT	,	_	_	_	_	_
66	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4143
# text = Addition of TFE-3, which binds to an E-box motif upstream of the LEF-1 and Ets-1 sites, further augments transcription in this system.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TFE	TFE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	box	box	NOUN	NN	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
27	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4144
# text = Individually or collectively, none of the three enhancer-binding proteins (LEF-1, Ets-1, and TFE-3) could activate transcription in the absence of Sp1.
1	Individually	individually	ADV	RB	_	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	none	none	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	TFE	TFE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	3	3	X	LS	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
26	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4145
# text = A truncation mutant of LEF-1 (HMG-88), which contains the HMG box but lacks the trans-activation domain, did not activate transcription from nucleosomal DNA, indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
3	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	88	88	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	_
18	box	box	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	nucleosomal	nucleosomal	ADJ	JJ	Degree=Pos	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	bending	bend	VERB	VBG	VerbForm=Ger	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
43	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
47	to	to	PART	TO	_	_	_	_	_
48	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
49	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4146
# text = We conclude that transcription activation by LEF-1 in vitro is a chromatin-dependent process that requires a functional trans-activation domain in addition to the HMG domain.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	process	process	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
22	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
30	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4147
# text = Document 003003692 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003692	003003692	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4148
# text = Lymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the 1 alpha,25-dihydroxyvitamin D3 receptor.
1	Lymphocyte	Lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
6	D-	D-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	rickets	ricket	NOUN	NNS	Number=Plur	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	II	II	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
13	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-dihydroxyvitamin	-dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
19	D3	D3	NUM	CD	NumType=Card	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4149
# text = Lymphocyte cell lines were established from five patients with vitamin D-dependent rickets, type II (VDDR-II).
1	Lymphocyte	Lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	five	five	NUM	CD	NumType=Card	_	_	_	_
8	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
11	D-	D-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	rickets	ricket	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	II	ii	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	VDDR	Vddr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4150
# text = These lines were established by infection with human T-lymphotrophic virus type I (HTLV-I).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	lymphotrophic	lymphotrophic	ADJ	JJ	Degree=Pos	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4151
# text = Binding of [3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) to its receptor in these cell lines was compared to binding studies using a T-lymphocyte cell line (S-LB1) from a normal individual.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	3H	3H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
8	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
28	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	S	s	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	LB1	Lb1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
42	individual	individual	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4152
# text = The 1,25(OH)2D3 receptor of S-LB1 was comparable to the well-characterized chick intestinal 1,25(OH)2D3 receptor in terms of its ligand binding affinity and capacity, its mobility on 5-20% sucrose gradients, and its adsorption to and elution properties from DNA-cellulose.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	S	S	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	LB1	LB1	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	chick	chick	NOUN	NN	Number=Sing	_	_	_	_
20	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
21	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	%	%	SYM	NN	Number=Sing	_	_	_	_
44	sucrose	sucrose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
45	gradients	gradient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
49	adsorption	adsorption	NOUN	NN	Number=Sing	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	elution	elution	NOUN	NN	Number=Sing	_	_	_	_
53	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
54	from	from	ADP	IN	_	_	_	_	_
55	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	cellulose	cellulose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4153
# text = Three cell lines established from patients with VDDR-II (Rh-VDR, Sh-VDR, and Ab-VDR) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 (24,25(OH)2D3), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	VDDR	VDDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	II	II	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Rh-	Rh-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Sh	Sh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	no	no	DET	DT	_	_	_	_	_
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
49	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
50	not	not	PART	RB	_	_	_	_	_
51	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
52	production	production	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	24,25	24,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	-dihydroxy-	-dihydroxy-	PUNCT	:	_	_	_	_	SpaceAfter=No
56	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
57	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	24,25	24,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
65	,	,	PUNCT	,	_	_	_	_	_
66	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
67	response	response	NOUN	NN	Number=Sing	_	_	_	_
68	which	which	PRON	WDT	PronType=Rel	_	_	_	_
69	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
70	diagnostic	diagnostic	ADJ	JJ	Degree=Pos	_	_	_	_
71	of	of	ADP	IN	_	_	_	_	_
72	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
73	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
74	of	of	ADP	IN	_	_	_	_	_
75	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
76	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
77	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
78	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
79	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
80	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
81	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
82	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4154
# text = In a fourth cell line, A1-VDR, the receptor for 1,25(OH)2D3 had a low binding capacity and 25(OH)D3-24-hydroxylase activity was not detectable.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	fourth	fourth	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	A1	A1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
19	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
23	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	D	d	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	3-	3-	PUNCT	:	_	_	_	_	SpaceAfter=No
31	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4155
# text = Induction of 24,25-(OH)2D3 synthesis by 1,25(OH)2D3 was observed in the fifth cell line, designated Ro-VDR, although the sensitivity to hormone treatment was lower than in the control cell line from a normal donor.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	24,25	24,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
5	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
8	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	fifth	fifth	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Ro	Ro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	although	although	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	hormone	hormone	VERB	VB	VerbForm=Inf	_	_	_	_
33	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
36	than	than	ADP	IN	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	control	control	NOUN	NN	Number=Sing	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	line	line	NOUN	NN	Number=Sing	_	_	_	_
42	from	from	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
45	donor	donor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4156
# text = The capacity of the receptor for 1,25(OH)2D3 was low in Ro-VDR.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	Ro	Ro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4157
# text = In all cell lines where 1,25(OH)2D3 binding to a receptor was detectable, the receptor had the typical sedimentation coefficient of 3.7 S on sucrose density gradient analysis.
1	In	in	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	where	where	ADV	WRB	PronType=Int	_	_	_	_
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
23	sedimentation	sedimentation	NOUN	NN	Number=Sing	_	_	_	_
24	coefficient	coefficient	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	3.7	3.7	NUM	CD	NumType=Card	_	_	_	_
27	S	s	NOUN	NN	Number=Sing	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	sucrose	sucrose	NOUN	NN	Number=Sing	_	_	_	_
30	density	density	NOUN	NN	Number=Sing	_	_	_	_
31	gradient	gradient	NOUN	NN	Number=Sing	_	_	_	_
32	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4158
# text = Binding and elution properties to DNA-cellulose, however, differed from normal in both Ro-VDR and A1-VDR cells where elution from DNA-cellulose occurred at a lower salt concentration than is typical of the 1,25(OH)2D3 receptor.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	elution	elution	NOUN	NN	Number=Sing	_	_	_	_
4	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	cellulose	cellulose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	Ro	Ro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-VDR	-VDR	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	A1	A1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	where	where	ADV	WRB	PronType=Rel	_	_	_	_
25	elution	elution	NOUN	NN	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	cellulose	cellulose	NOUN	NN	Number=Sing	_	_	_	_
30	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
34	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
35	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
36	than	than	ADP	IN	_	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
46	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4159
# text = While Ro-VDR cells showed typical nuclear localization of the unoccupied 1,25(OH)2D3 receptor, neither the unoccupied nor the occupied receptor from A1-VDR cells was completely localized in the nucleus.
1	While	while	SCONJ	IN	_	_	_	_	_
2	Ro	Ro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	unoccupied	unoccupied	ADJ	JJ	Degree=Pos	_	_	_	_
13	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	neither	neither	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	unoccupied	unoccupied	ADJ	JJ	Degree=Pos	_	_	_	_
23	nor	nor	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	A1	A1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	completely	completely	ADV	RB	_	_	_	_	_
34	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4160
# text = In a series of functional studies we found that modulation of the level of the mRNAs coding for both the c-myc oncogene and the growth factor known as granulocyte-monocyte colony stimulating activity by 1,25(OH)2D3 correlated with the 1,25(OH)2D3 receptor status of these cells.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	series	series	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	_
17	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
23	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
33	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
34	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
42	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
50	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
51	status	status	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4161
# text = Use of these cell lines will facilitate further study of the molecular defect(s) in the receptor for 1,25(OH)2D3 in vitamin D-dependent rickets type II and will allow a correlation with impairment of cellular functions.
1	Use	use	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
7	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
8	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
9	study	study	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	defect	defect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	s	s	X	AFX	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
28	D-	D-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	rickets	ricket	NOUN	NNS	Number=Plur	_	_	_	_
31	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
35	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	impairment	impairment	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
42	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4162
# text = Document 003003693 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003693	003003693	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4163
# text = Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	Treponema	Treponema	PROPN	NNP	Number=Sing	_	_	_	_
8	pallidum	pallidum	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Borrelia	Borrelia	PROPN	NNP	Number=Sing	_	_	_	_
11	burgdorferi	burgdorferi	ADJ	JJ	Degree=Pos	_	_	_	_
12	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
15	lipopeptides	lipopeptide	NOUN	NNS	Number=Plur	_	_	_	_
16	proceeds	proceed	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4164
# text = There is increasing evidence that lipoproteins of Treponema pallidum and Borrelia burgdorferi are key inflammatory mediators during syphilis and Lyme disease.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Treponema	Treponema	PROPN	NNP	Number=Sing	_	_	_	_
9	pallidum	pallidum	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Borrelia	Borrelia	PROPN	NNP	Number=Sing	_	_	_	_
12	burgdorferi	burgdorferus	PRON	PRP	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	syphilis	syphilis	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Lyme	Lyme	ADJ	JJ	Degree=Pos	_	_	_	_
21	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4165
# text = A principal objective of the present study was to identify more precisely similarities and divergences among lipopolysaccharide (LPS)- and lipoprotein-lipopeptide-induced immune cell signaling events.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	principal	principal	ADJ	JJ	Degree=Pos	_	_	_	_
3	objective	objective	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	study	study	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
11	more	more	ADV	RBR	_	_	_	_	_
12	precisely	precisely	ADV	RB	_	_	_	_	_
13	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	divergences	divergence	NOUN	NNS	Number=Plur	_	_	_	_
16	among	among	ADP	IN	_	_	_	_	_
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	lipoprotein-lipopeptide	lipoprotein-lipopeptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	immune	immune	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
29	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4166
# text = Like LPS, purified native B. burgdorferi OspA and synthetic analogs of OspA, OspB, and two T. pallidum lipoproteins (Tpp47 and Tpp17) all induced NF-kappa B translocation in THP-1 human monocytoid cells.
1	Like	like	ADP	IN	_	_	_	_	_
2	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	purified	purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
6	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
7	burgdorferi	burgdorferi	PROPN	NNP	Number=Sing	_	_	_	_
8	OspA	OspA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
11	analogs	analog	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	OspA	OspA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	OspB	OspB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	T.	T.	NOUN	NN	Number=Sing	_	_	_	_
20	pallidum	pallidum	NOUN	NN	Number=Sing	_	_	_	_
21	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Tpp47	Tpp47	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Tpp17	Tpp17	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	all	all	DET	DT	_	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	THP	THP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	monocytoid	monocytoid	NOUN	NN	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4167
# text = Acylation of OspA and the synthetic peptides was requisite for cell activation.
1	Acylation	Acylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	OspA	OspA	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	requisite	requisite	VERB	VB	VerbForm=Inf	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4168
# text = Polymyxin B abrogated only the response to LPS.
1	Polymyxin	Polymyxin	PROPN	NNP	Number=Sing	_	_	_	_
2	B	B	PROPN	NNP	Number=Sing	_	_	_	_
3	abrogated	abrogate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4169
# text = By using 70Z/3-derived pre-B-cell lines either lacking or expressing human CD14 (the LPS receptor), it was observed that expression of human CD14 imparted responsiveness to LPS but not to OspA or spirochetal lipopeptides (assessed by induction of NF-kappa B and expression of surface immunoglobulin M).
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	70Z/3	70Z/3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
7	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	lacking	lack	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	14	14	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	14	14	NUM	CD	NumType=Card	_	_	_	_
33	imparted	impart	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	OspA	OspA	PROPN	NNP	Number=Sing	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	spirochetal	spirochetal	ADJ	JJ	Degree=Pos	_	_	_	_
43	lipopeptides	lipopeptide	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
52	B	b	NOUN	NN	Number=Sing	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
57	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
58	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4170
# text = Finally, the biological relevance of the observation that T. pallidum lipoproteins-lipopeptides induce both NF-kappa B and cytokine production in monocytes was supported by the ability of the synthetic analogs to promote human immunodeficiency virus replication in chronically infected U1 monocytoid cells; these observations also suggest a potential mechanism whereby a syphilitic chancre can serve as a cofactor for human immunodeficiency virus transmission.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
5	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_
11	pallidum	pallidum	NOUN	NN	Number=Sing	_	_	_	_
12	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	lipopeptides	lipopeptide	NOUN	NNS	Number=Plur	_	_	_	_
15	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	supported	support	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
34	analogs	analog	NOUN	NNS	Number=Plur	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
39	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
40	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	chronically	chronically	ADV	RB	_	_	_	_	_
43	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	U1	u1	NUM	CD	NumType=Card	_	_	_	_
45	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
49	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
50	also	also	ADV	RB	_	_	_	_	_
51	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
54	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
55	whereby	whereby	ADP	IN	_	_	_	_	_
56	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
57	syphilitic	syphilitic	ADJ	JJ	Degree=Pos	_	_	_	_
58	chancre	chancre	NOUN	NN	Number=Sing	_	_	_	_
59	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
60	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
61	as	as	ADP	IN	_	_	_	_	_
62	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
63	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
64	for	for	ADP	IN	_	_	_	_	_
65	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
66	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
67	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
68	transmission	transmission	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4171
# text = The combined data lend additional support to the proposal that spirochetal lipoproteins and LPS initiate monocyte activation via different cell surface events but that the signaling pathways ultimately converge to produce qualitatively similar cellular responses.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	lend	lend	NOUN	NN	Number=Sing	_	_	_	_
5	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
6	support	support	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	proposal	proposal	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	spirochetal	spirochetal	ADJ	JJ	Degree=Pos	_	_	_	_
12	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
15	initiate	initiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	events	event	NOUN	NNS	Number=Plur	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
27	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
28	ultimately	ultimately	ADV	RB	_	_	_	_	_
29	converge	converge	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
32	qualitatively	qualitatively	ADV	RB	_	_	_	_	_
33	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
34	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
35	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4172
# text = Document 003003702 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003702	003003702	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4173
# text = The Epstein-Barr virus latency BamHI-Q promoter is positively regulated by STATs and Zta interference with JAK/STAT activation leads to loss of BamHI-Q promoter activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
7	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Q	q	PROPN	NNP	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	positively	positively	ADV	RB	_	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	STATs	STATs	PROPN	NNPS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Zta	Zta	PROPN	NNP	Number=Sing	_	_	_	_
18	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	loss	loss	VERB	VB	VerbForm=Inf	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	Q	q	PROPN	NNP	Number=Sing	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4174
# text = In Epstein-Barr virus (EBV)-associated tumors in nonimmunocompromised patients, EBV gene expression is highly restricted.
1	In	in	ADP	IN	_	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	nonimmunocompromised	nonimmunocompromise	ADJ	JJ	Degree=Pos	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	highly	highly	ADV	RB	_	_	_	_	_
21	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4175
# text = EBV-encoded nuclear antigen (EBNA)-1 is expressed, whereas the immunogenic and proliferative EBNAs are not.
1	EBV	haEbve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	encoded	encod	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whereas	whereas	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
19	EBNAs	EBNA	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4176
# text = This pattern of EBNA expression is generated by usage of the BamHI-Q promoter (Qp).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	usage	usage	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Q	q	PROPN	NNP	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	Qp	Qp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4177
# text = We have determined that the JAK/STAT pathway positively regulates Qp activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	positively	positively	ADV	RB	_	_	_	_	_
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	Qp	Qp	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4178
# text = In transient-transfection assays, a Qp-CAT reporter was activated by cotransfected JAK-1 and by treatment of cells with the cytokine IL-6.
1	In	in	ADP	IN	_	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	Qp	Qp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4179
# text = The ability of Qp to bind signal transducer and activator of transcription (STAT) proteins was directly demonstrated by electrophoretic mobility-shift assay, and mutation of potential STAT-binding sites reduced Qp responsiveness to Janus kinase (JAK)-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Qp	Qp	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
8	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	directly	directly	ADV	RB	_	_	_	_	_
19	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
22	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
25	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
31	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	Qp	Qp	PROPN	NNP	Number=Sing	_	_	_	_
37	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4180
# text = Consistent with a role for STATs in Qp function, Qp using Burkitt's lymphoma Rael cells and cultured nasopharyngeal carcinoma (NPC) cells contained nuclear
1	Consistent	consistent	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	STATs	STATs	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	Qp	Qp	NOUN	NN	Number=Sing	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Qp	Qp	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
13	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	's	's	PART	POS	_	_	_	_	_
15	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
16	Rael	Rael	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
21	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NPC	NPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 4181
# text = STAT protein.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4182
# text = We investigated whether the inability to maintain EBV-positive NPC cell lines in culture was related to Qp activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
8	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	NPC	Npc	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	Qp	Qp	VERB	VB	VerbForm=Inf	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4183
# text = Passaging of the NPC cell line HK666 led to activation of expression of BZLF1, which encodes Zta and loss of Qp function.
1	Passaging	Passaging	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NPC	NPC	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	HK666	HK666	PROPN	NNP	Number=Sing	_	_	_	_
8	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	Zta	Zta	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	loss	lose	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Qp	Qp	NOUN	NN	Number=Sing	_	_	_	_
23	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4184
# text = Transient expression assays linked Zta expression to the down-regulation of Qp.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
4	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	Zta	Zta	PROPN	NNP	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Qp.	Qp.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4185
# text = Cotransfection of Zta reduced Qp activity in reporter assays.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Zta	Zta	PROPN	NNP	Number=Sing	_	_	_	_
4	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Qp	Qp	PROPN	NNP	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4186
# text = This negative regulation required Zta DNA-binding activity.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Zta	Zta	PROPN	NNP	Number=Sing	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4187
# text = We provide evidence that Zta up-regulation of p53 leads to p53-mediated interference with JAK/STAT activation of Qp.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	Zta	Zta	PROPN	NNP	Number=Sing	_	_	_	_
6	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p53	p53	NUM	CD	NumType=Card	_	_	_	_
11	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	p53	p53	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
15	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Qp	Qp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4188
# text = The data imply that JAK/STAT signaling has a role in EBV-associated malignancies.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	associated	associated	ADJ	JJ	Degree=Pos	_	_	_	_
16	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4189
# text = Document 003003706 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003706	003003706	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4190
# text = Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.
1	Lipopolysaccharide	Lipopolysaccharide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	MAD3	MAD3	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
14	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4191
# text = Many effects of lipopolysaccharide (LPS) on gene expression, including that of human immunodeficiency virus (HIV), in monocytic cells are mediated by activation of kappa B DNA-binding proteins.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4192
# text = However, the specific members of the NF-kappa B/Rel transcription factor family involved in the LPS response, and the mechanisms through which LPS-generated signals are transduced remain unclear.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	members	member	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4193
# text = Here we show that LPS induces nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	p50	p50	NUM	CD	NumType=Card	_	_	_	_
14	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
20	p65	p65	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4194
# text = Nuclear localization of these proteins occurred concomitantly with a rapid decrease in their cytosolic levels and was independent of phorbol ester-sensitive protein kinase C. Within 24 h following LPS stimulation there was a striking increase in the levels of c-Rel, p105, and p50 in the cytosol.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	concomitantly	concomitantly	ADV	RB	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
11	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
21	ester-sensitive	ester-sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_
26	Within	within	ADP	IN	_	_	_	_	_
27	24	24	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	_
29	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
30	LPS	Lp	ADJ	JJ	Degree=Pos	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
32	there	there	ADV	RB	PronType=Dem	_	_	_	_
33	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	striking	striking	VERB	VBG	VerbForm=Ger	_	_	_	_
36	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	p50	p50	NUM	CD	NumType=Card	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4195
# text = The increased levels of these proteins correlated with increases in the amounts of their mRNAs during LPS activation of THP-1 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4196
# text = LPS activation of THP-1 cells resulted in phosphorylation of MAD3 (an I kappa B-like protein), a rapid increase in MAD3 mRNA, and an increase in MAD3 protein by 2 h.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	MAD3	MAD3	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
25	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	MAD3	MAD3	NUM	CD	NumType=Card	_	_	_	_
28	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	MAD3	MAD3	NUM	CD	NumType=Card	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4197
# text = Thus, LPS activation of human monocytic cells results in nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B) and induces phosphorylation of MAD3.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	Rel/p50	Rel/p50	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
19	p65	p65	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
28	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	MAD3	MAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4198
# text = Document 003003707 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003707	003003707	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4199
# text = The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
7	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4200
# text = The tumor necrosis factor-alpha (TNF alpha) gene is an immediate early gene in activated T cells, in that it is rapidly induced without a requirement for protein synthesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
3	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	rapidly	rapidly	ADV	RB	_	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	without	without	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4201
# text = Maximal induction of TNF alpha mRNA can be induced by treatment of T cells with calcium ionophores alone, via a calcineurin-dependent process that is blocked by cyclosporin A.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
5	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
17	ionophores	ionophore	NOUN	NNS	Number=Plur	_	_	_	_
18	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	via	via	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	process	process	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
31	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4202
# text = We have previously identified a promoter element, kappa 3, that is required for calcium-stimulated, cyclosporin A-sensitive induction of the TNF alpha gene in activated T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	calcium-	calcium-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
20	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4203
# text = Here, we demonstrate that the kappa 3 binding factor contains NFATp, a cyclosporin-sensitive DNA-binding protein required for interleukin-2 gene transcription.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	cyclosporin-	cyclosporin-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4204
# text = NFATp binds to two sites within the kappa 3 element, and occupancy of both sites is required for TNF alpha gene induction.
1	NFATp	NFATp	ADJ	JJ	Degree=Pos	_	_	_	_
2	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	ADV	RB	_	_	_	_	_
22	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4205
# text = Thus, although the kappa 3 element has little sequence similarity to other NFATp-binding sites, it appears to function as a cyclosporin-sensitive promoter element in T cells by virtue of its ability to bind NFATp.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	cyclosporin-	cyclosporin-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	virtue	virtue	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
39	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4206
# text = The involvement of NFATp in transcriptional activation of both the interleukin-2 and TNF alpha genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes, starting at the earliest stages of T cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
17	genes	gene	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	starting	start	VERB	VBG	VerbForm=Ger	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
39	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	T	t	PROPN	NNP	Number=Sing	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4207
# text = Document 003003710 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003710	003003710	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4208
# text = Comparison of retinoic acid and phorbol myristate acetate as inducers of monocytic differentiation.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
4	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
7	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
8	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4209
# text = Several human myeloid leukemia cell lines growing in vitro can be induced to differentiate to more mature monocyte/macrophage-like cells by treatment with protein kinase C-activating phorbol esters, such as PMA.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	macrophage-like	macrophage-like	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
30	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4210
# text = In addition to PMA, cells of the THP-1 myeloid leukemia cell line acquire macrophage-like characteristics after treatment with all-trans retinoic acid (RA).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	acquire	acquire	NOUN	NN	Number=Sing	_	_	_	_
17	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
20	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	all	all	DET	DT	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
27	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
28	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4211
# text = To analyze the signal transduction mechanisms induced by RA, we first compared the effects of PMA and RA on the expression of genes which are known to be regulated during monocytic differentiation.
1	To	to	PART	TO	_	_	_	_	_
2	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	first	first	ADV	RB	_	_	_	_	_
13	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	during	during	ADP	IN	_	_	_	_	_
32	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4212
# text = Both RA and PMA effectively down-regulated c-myc expression, while c-myb expression decreased only after PMA treatment.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
5	effectively	effectively	ADV	RB	_	_	_	_	_
6	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	while	while	SCONJ	IN	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	only	only	ADV	RB	_	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
21	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4213
# text = Expression of the beta 2-integrin genes, CD11a and CD11b, was clearly increased after both of these treatments.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	CD11	CD11	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD11	Cd11	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	clearly	clearly	ADV	RB	_	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	treatments	treatment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4214
# text = Their effects on the src-family tyrosine kinase genes were different: hck expression was similarly induced by these agents but lyn expression was stronger and more rapid after RA treatment.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	src-	src-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	hck	hck	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	similarly	similarly	ADV	RB	_	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	lyn	lyn	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	more	more	ADV	RBR	_	_	_	_	_
28	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
31	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4215
# text = RA also enhanced lyn mRNA production rapidly in HL-60, indicating that the activation of lyn gene expression is common in monocytic and granulocytic maturation of myeloid leukemia cells.
1	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	lyn	lyn	ADJ	JJ	Degree=Pos	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	rapidly	rapidly	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	lyn	lyn	ADJ	JJ	Degree=Pos	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4216
# text = To examine whether the AP-1 enhancer activity is involved in RA-induced monocytic differentiation, THP-1 cells were transiently transfected with a chloramphenicol acetyl transferase (CAT)-reporter gene containing 5 copies of the AP-1 binding sites.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	transiently	transiently	ADV	RB	_	_	_	_	_
25	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
29	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
30	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	CAT	Cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
38	5	5	NUM	CD	NumType=Card	_	_	_	_
39	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
46	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4217
# text = In contrast to PMA, RA did not induce any CAT activity in these cells, thus suggesting that the RA-induced changes in the expression of those genes described above were not dependent on the AP-1 enhancer activity.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	any	any	DET	DT	_	_	_	_	_
11	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	thus	thus	ADV	RB	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	above	above	ADV	RB	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	on	on	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4218
# text = Document 003003718 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003718	003003718	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4219
# text = Modulation of E2F complexes during G0 to S phase transition in human primary B-lymphocytes.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	F	F	PROPN	NNP	Number=Sing	_	_	_	_
5	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	G0	G0	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	S	S	PROPN	NNP	Number=Sing	_	_	_	_
10	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
11	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4220
# text = The pocket protein-E2F complexes are convergence points for cell cycle signaling.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pocket	pocket	NOUN	NN	Number=Sing	_	_	_	_
3	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	F	f	NOUN	NN	Number=Sing	_	_	_	_
6	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	convergence	convergence	NOUN	NN	Number=Sing	_	_	_	_
9	points	point	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4221
# text = In the present report, we identified and monitored the pocket protein-E2F complexes in human primary B-lymphocytes after activation by phorbol 12-myristate 13-acetate.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	monitored	monitor	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	pocket	pocket	NOUN	NN	Number=Sing	_	_	_	_
12	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	F	f	PROPN	NNP	Number=Sing	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	after	after	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
26	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
29	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
31	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4222
# text = Consistent with previous data from human and mouse fibroblasts and T-lymphocytes, E2F4 and DP1 form the predominant E2F heterodimers both in G0 and G1 phases of the human B-lymphocyte cell cycle, whereas E2F1 and -3 are first detected in late G1, and their expression levels increase towards S phase.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	human	human	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	E2F4	E2F4	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	DP1	DP1	PROPN	NNP	Number=Sing	_	_	_	_
17	form	form	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
20	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	_
21	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	G0	G0	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	G1	G1	NUM	CD	NumType=Card	_	_	_	_
27	phases	phasis	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	whereas	whereas	SCONJ	IN	_	_	_	_	_
38	E2F1	E2F1	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	3	3	NUM	CD	NumType=Card	_	_	_	_
42	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
43	first	first	ADV	RB	_	_	_	_	_
44	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
47	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
51	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
53	increase	increase	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
54	towards	toward	ADP	IN	_	_	_	_	_
55	S	's	NOUN	NN	Number=Sing	_	_	_	_
56	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4223
# text = Intriguingly, the major E2F complex that we detected in quiescent human B-lymphocytes is consisted of pRB, E2F4, and DP1.
1	Intriguingly	Intriguingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	E2	e2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	F	f	PROPN	NNP	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	pRB	pRB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	E2F4	E2F4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	DP1	DP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4224
# text = Though the levels of DP1 and -2 increase when cells progress from G0 to S, the proportion of DP1 to DP2 remains relatively constant during the cell cycle.
1	Though	though	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	DP1	DP1	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	progress	progress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	G0	G0	PROPN	NNP	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	S	s	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	DP1	DP1	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	DP2	DP2	NUM	CD	NumType=Card	_	_	_	_
24	remains	remains	NOUN	NNS	Number=Plur	_	_	_	_
25	relatively	relatively	ADV	RB	_	_	_	_	_
26	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4225
# text = We also observed an increase in electrophoretic mobility of the predominant E2F components, DP1 and E2F4, as B-lymphocytes progressed from G0 into early G1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
8	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
12	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	_
13	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	DP1	DP1	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	E2F4	E2F4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	progressed	progress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	G0	G0	PROPN	NNP	Number=Sing	_	_	_	_
26	into	into	ADP	IN	_	_	_	_	_
27	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
28	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4226
# text = This increase in mobility was attributable to dephosphorylation, as lambda phosphatase treatment could convert the slower migrating forms into the corresponding faster mobility forms.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_
12	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
13	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	convert	convert	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	slower	slower	NOUN	NN	Number=Sing	_	_	_	_
18	migrating	migrat	VERB	VBG	VerbForm=Ger	_	_	_	_
19	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
20	into	into	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
23	faster	faster	NOUN	NN	Number=Sing	_	_	_	_
24	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
25	forms	form	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4227
# text = We further demonstrated that this change in phosphorylation status correlates with a decrease in DNA binding activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	change	change	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	status	status	NOUN	NN	Number=Sing	_	_	_	_
10	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4228
# text = This modulation of DNA binding activity mediated through the dephosphorylation of DP1 and E2F4 could help to explain the lack of in vivo DNA footprinting in late G1 and S phases of gene promoters negatively regulated through E2F sites and suggests a novel mechanism for controlling E2F transcriptional activity during the transition from quiescence to proliferation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	DP1	DP1	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	E2F4	E2F4	PROPN	NNP	Number=Sing	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	help	help	VERB	VB	VerbForm=Inf	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	footprinting	footprinting	VERB	VBG	VerbForm=Ger	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
28	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	S	s	NOUN	NN	Number=Sing	_	_	_	_
31	phases	phasis	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
35	negatively	negatively	ADV	RB	_	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	through	through	ADP	IN	_	_	_	_	_
38	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	F	F	PROPN	NNP	Number=Sing	_	_	_	_
40	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
45	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
46	for	for	SCONJ	IN	_	_	_	_	_
47	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
48	E2F	E2F	ADP	RP	_	_	_	_	_
49	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
50	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
51	during	during	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
54	from	from	ADP	IN	_	_	_	_	_
55	quiescence	quiescence	NOUN	NN	Number=Sing	_	_	_	_
56	to	to	ADP	IN	_	_	_	_	_
57	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4229
# text = Document 003003719 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003719	003003719	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4230
# text = SCL and related hemopoietic helix-loop-helix transcription factors.
1	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4231
# text = The helix-loop-helix (HLH) proteins are a family of transcription factors that include proteins critical to differentiation and development in species ranging from plants to mammals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HLH	HLH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	species	species	NOUN	NNS	Number=Plur	_	_	_	_
25	ranging	range	VERB	VBG	VerbForm=Ger	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	plants	plant	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	mammals	mammal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4232
# text = Five members of this family (MYC, SCL, TAL-2, LYL-1 and E2A) are implicated in oncogenic events in human lymphoid tumors because of their consistent involvement in chromosomal translocations.
1	Five	five	NUM	CD	NumType=Card	_	_	_	_
2	members	member	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	family	family	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	MYC	MYC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TAL	TAL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	LYL	LYL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	E2A	E2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	events	event	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
29	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
30	because	because	ADP	IN	_	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
34	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
37	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4233
# text = Although activated in T cell leukemias, expression of SCL and LYL-1 is low or undetectable in normal T cell populations.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	LYL	LYL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4234
# text = SCL is expressed in erythroid, megakaryocyte and mast cell populations (the same cell lineages as GATA-1, a zinc-finger transcription factor).
1	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	megakaryocyte	megakaryocyte	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	mast	mast	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4235
# text = In addition, both SCL and GATA-1 undergo coordinate modulation during chemically induced erythroid differentiation of mouse erythroleukemia cells and are down-modulated during myeloid differentiation of human K562 cells, thus implying a role for SCL in erythroid differentiation events.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	undergo	undergo	NOUN	NN	Number=Sing	_	_	_	_
11	coordinate	coordinate	NOUN	NN	Number=Sing	_	_	_	_
12	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	chemically	chemically	ADV	RB	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
20	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	K562	K562	NOUN	NN	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	thus	thus	ADV	RB	_	_	_	_	_
36	implying	imply	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	role	role	NOUN	NN	Number=Sing	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
43	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
44	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4236
# text = However, in contrast to GATA-1, SCL is expressed in the developing brain.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
16	brain	brain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4237
# text = Studies of the function of SCL suggest it is also important in proliferation and self-renewal events in erythroid cells.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
7	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	renewal	renewal	NOUN	NN	Number=Sing	_	_	_	_
18	events	event	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4238
# text = Document 003003722 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003722	003003722	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4239
# text = Tumor necrosis factor-alpha mRNA accumulation in human myelomonocytic cell lines.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4240
# text = Role of transcriptional regulation by DNA sequence motifs and mRNA stabilization.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4241
# text = The cytokine TNF mediates many of the pathologic signs of cachexia, inflammation, and sepsis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
3	TNF	TNF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
4	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	pathologic	pathologic	NOUN	NN	Number=Sing	_	_	_	_
9	signs	sign	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cachexia	cachexia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	sepsis	sepsis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4242
# text = The current work describes the regulation of TNF in human myelomonocytic cell lines after PMA stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	describes	describe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4243
# text = The cell lines exhibit a low level of constitutive TNF mRNA expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	exhibit	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4244
# text = Within 2 to 4 h of PMA exposure, steady state levels of TNF mRNA are markedly elevated in all myelomonocytic cell lines studied.
1	Within	within	ADP	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	h	h	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
8	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
11	state	state	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
15	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	markedly	markedly	ADV	RB	_	_	_	_	_
18	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	all	all	DET	DT	_	_	_	_	_
21	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4245
# text = This rise is due to increased mRNA stability, which increased by almost twofold, and to an overall increase in transcription, which rises by more than sixfold.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	due	due	ADP	IN	_	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
8	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	almost	almost	ADV	RB	_	_	_	_	_
14	twofold	twofold	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
20	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	rises	rise	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	sixfold	sixfold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4246
# text = At the level of the genomic TNF gene, a DNase I hypersensitive site is detected within the TNF promoter between -200 to -100 bp relative to the transcription initiation site.
1	At	at	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	level	level	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
7	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	-200	-200	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	100	100	NUM	CD	NumType=Card	_	_	_	_
26	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
27	relative	relative	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4247
# text = Although absent in nonexpressing erythroleukemia cell lines, the DNase I site is present in uninduced myelomonocytic cell lines and is not changed after PMA induction.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	nonexpressing	nonexpresse	ADJ	JJ	Degree=Pos	_	_	_	_
5	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
17	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	changed	change	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4248
# text = The PMA induction of c-fos mRNA correlated well with TNF gene induction; expression of genes encoding other proteins in the AP-1 complex (junB and junD) were also induced by PMA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	well	well	ADV	RB	Degree=Pos	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
13	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	junB	junb	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	junD	jund	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4249
# text = The nuclear extracts from resting and induced ML-1 cells contain proteins binding specifically to the AP-1, AP-2, and NF kappa B sequence located within the TNF promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	SCONJ	IN	_	_	_	_	_
5	resting	resting	VERB	VBG	VerbForm=Ger	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	ML	ML	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	specifically	specifically	ADV	RB	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	within	within	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4250
# text = PMA induction increases the level of a number of specific binding complexes relative to the resting cells.
1	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	level	level	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	relative	relative	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	resting	resting	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4251
# text = The regulatory mechanisms of the human and murine TNF genes are discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4252
# text = Document 003003724 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003724	003003724	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4253
# text = Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
8	target	target	NOUN	NN	Number=Sing	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4254
# text = The type I human T-cell leukemia virus (HTLV-I) induces abnormal growth and subsequent transformation of T cells, which is associated with the development of an acute T-cell malignancy termed adult T-cell leukemia.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	human	human	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
33	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	_
36	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
38	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4255
# text = A characteristic of HTLV-I-transformed
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 4256
# text = T cells is the constitutive nuclear expression of NF-kappaB/Rel family of transcription factors, which appears to be essential for the growth of these transformed cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	transformed	transformed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4257
# text = Although NF-kappaB/Rel factors are known to induce the expression of T-cell growth factor interleukin (IL)-2, it is unclear how they participate in the IL-2-independent growth of HTLV-I-transformed cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	how	how	ADV	WRB	PronType=Int	_	_	_	_
30	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
31	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
39	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4258
# text = In this study, we show that certain NF-kappaB/Rel members, predominantly c-Rel, interact with enhancer sequences for STAT5, a key transcription factor mediating IL-2-induced T-cell proliferation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
14	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	predominantly	predominantly	ADV	RB	_	_	_	_	_
17	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4259
# text = Reporter gene assays reveal that the binding of c-Rel to the STAT5 site present in the Fc gammaR1 gene leads to potent transactivation of this enhancer.
1	Reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Fc	Fc	ADJ	JJ	Degree=Pos	_	_	_	_
20	gammaR1	gammar1	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	potent	potent	VERB	VB	VerbForm=Inf	_	_	_	_
25	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4260
# text = Binding of c-Rel to the Fc gammaR1
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
9	gammaR1	gammaR1	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4261
# text = STAT site also occurs in human peripheral blood T cells immortalized with HTLV-I in vitro and is correlated with enhanced levels of proliferation of these cells.
1	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4262
# text = These results raise the possibility that NF-kappaB/Rel may participate in the growth control of HTLV-I-transformed T cells by regulating genes driven by both kappaB and certain
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	raise	raise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	control	control	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	by	by	SCONJ	IN	_	_	_	_	_
27	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
29	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	both	both	CCONJ	CC	_	_	_	_	_
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 4263
# text = STAT enhancers.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4264
# text = Document 003003727 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003727	003003727	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4265
# text = Erythropoietin stimulates transcription of the TAL1/SCL gene and phosphorylation of its protein products.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
2	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TAL1/	Tal1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4266
# text = Activation of the TAL1 (or SCL) gene, originally identified through its involvement by a recurrent chromosomal translocation, is the most frequent molecular lesion recognized in T-cell acute lymphoblastic leukemia.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	or	or	CCONJ	CC	_	_	_	_	_
7	SCL	SCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	originally	originally	ADV	RB	_	_	_	_	_
12	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	recurrent	recurrent	ADJ	JJ	Degree=Pos	_	_	_	_
19	chromosomal	chromosomal	NOUN	NN	Number=Sing	_	_	_	_
20	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	most	most	ADV	RBS	_	_	_	_	_
25	frequent	frequent	ADJ	JJ	Degree=Pos	_	_	_	_
26	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
27	lesion	lesion	NOUN	NN	Number=Sing	_	_	_	_
28	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
33	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
34	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4267
# text = The protein products of this gene contain the basic-helix-loop-helix motif characteristic of a large family of transcription factors that bind to the canonical DNA sequence CANNTG as protein heterodimers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	products	product	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	basic-helix-loop	basic-helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-helix	-helix	NOUN	NN	Number=Sing	_	_	_	_
11	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
12	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	canonical	canonical	ADJ	JJ	Degree=Pos	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	CANNTG	Canntg	NOUN	NN	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4268
# text = TAL1 expression by erythroid cells in vivo and in chemical-induced erythroleukemia cell lines in vivo suggested the gene might regulate aspects of erythroid differentiation.
1	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	chemical	chemical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
18	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
22	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4269
# text = Since the terminal events of erythropoiesis are controlled by the glycoprotein hormone erythropoietin (Epo), we investigated whether the expression or activity of the TAL1 gene and its protein products were affected by Epo in splenic erythroblasts from mice infected with an anemia-inducing strain of Friend virus (FVA cells).
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	erythropoiesis	erythropoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
12	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
13	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	whether	whether	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	products	product	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
39	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
42	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	anemia	anemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
48	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	Friend	Friend	NOUN	NN	Number=Sing	_	_	_	_
51	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	FVA	FVa	ADJ	JJ	Degree=Pos	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4270
# text = Epo elicited a rapid, dose-related increase in TAL1 mRNA by increasing transcription of the gene and stabilizing one of its mRNAs.
1	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
2	elicited	elicit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	TAL1	TAL1	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	stabilizing	stabilize	VERB	VBG	VerbForm=Ger	_	_	_	_
21	one	one	NUM	CD	NumType=Card	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4271
# text = An Epo-inducible TAL1 DNA binding activity was identified in FVA cell nuclear extracts that subsequently decayed despite accumulating mRNA and protein.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	Epo-inducible	Epo-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
3	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	FVA	FVA	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	subsequently	subsequently	ADV	RB	_	_	_	_	_
16	decayed	decay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	despite	despite	SCONJ	IN	_	_	_	_	_
18	accumulating	accumulat	VERB	VBG	VerbForm=Ger	_	_	_	_
19	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4272
# text = Induction of DNA binding activity was associated temporally with Epo-induced phosphorylation of nuclear TAL1 protein.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	temporally	temporally	ADV	RB	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	Epo-induced	Epo-induce	ADJ	JJ	Degree=Pos	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	TAL1	tAL1	NUM	CD	NumType=Card	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4273
# text = These results indicate that Epo acts at both transcriptional and posttranscriptional levels on the TAL1 locus in Friend virus-induced erythroblasts and establish a link between Epo signaling mechanisms and a member of a family of transcription factors involved in the differentiation of diverse cell lineages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
6	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TAL1	tAL1	NUM	CD	NumType=Card	_	_	_	_
16	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Friend	Friend	PROPN	NNP	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	link	link	NOUN	NN	Number=Sing	_	_	_	_
27	between	between	ADP	IN	_	_	_	_	_
28	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
29	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
30	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	member	member	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	family	family	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
40	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4274
# text = Document 003003731 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003731	003003731	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4275
# text = C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes.
1	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
4	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
15	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
16	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4276
# text = Three binding sites for C/EBP proteins are found in the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) (V.M.
1	Three	three	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	EBP	Ebp	PROPN	NNP	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
24	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
25	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	V.M.	V.M.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4277
# text = Tesmer, A.Rajadhyaksha, J.Babin, and M.Bina, Proc.Natl.Acad.Sci. USA 90:7298-7302, 1993).
1	Tesmer	Tesmer	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	A.Rajadhyaksha	A.Rajadhyaksha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	J.Babin	J.Babin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	M.Bina	M.Bina	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Proc.Natl.Acad.Sci	Proc.Natl.Acad.Sci	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_
12	USA	USA	PROPN	NNP	Number=Sing	_	_	_	_
13	90:7298-7302	90:7298-7302	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	1993	1993	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4278
# text = We have determined the functional role of C/EBP proteins and C/EBP sites in regulating transcription from the HIV- 1 LTR in monocytes/macrophages.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	SCONJ	IN	_	_	_	_	_
18	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4279
# text = Inhibition of endogenous C/EBP proteins, using either an excess of C/EBP binding sites or a trans- dominant negative inhibitor, demonstrated that C/EBP proteins are required for basal and activated levels of HIV-1 LTR transcription in the promonocytic cell line U937.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	excess	excess	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	trans	tran	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	_
23	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	EBP	Ebp	PROPN	NNP	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
45	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	line	line	NOUN	NN	Number=Sing	_	_	_	_
51	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4280
# text = Northern (RNA) blots and binding assays showed that NF-IL6 is the only known C/EBP family member which is increased when U937 cells are activated.
1	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
21	family	family	NOUN	NN	Number=Sing	_	_	_	_
22	member	member	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	when	when	ADV	WRB	PronType=Int	_	_	_	_
27	U937	U937	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4281
# text = Mutational analyses of the HIV-1 LTR showed that one C/EBP site is required for normal LTR transcription both before and after cellular activation and that the two 3' C/EBP sites are functionally equivalent.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	before	before	ADV	RB	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	after	after	ADP	IN	_	_	_	_	_
26	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	'	'	PUNCT	``	_	_	_	_	_
34	C/	C/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	functionally	functionally	ADV	RB	_	_	_	_	_
39	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4282
# text = However, transcription from crippled HIV-1 LTRs lacking C/EBP sites can still be induced following activation of U937 cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	crippled	crippl	ADJ	JJ	Degree=Pos	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
10	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
11	C/	C/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
12	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	still	still	ADV	RB	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	U937	U937	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4283
# text = Several models are suggested for how elevated NF-IL6 may participate in an autostimulatory loop involving HIV infection, macrophage activation, cytokine expression, and HIV replication.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	models	model	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	for	for	SCONJ	IN	_	_	_	_	_
6	how	how	ADV	WRB	PronType=Int	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	autostimulatory	autostimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
17	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
19	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
29	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4284
# text = Document 003003732 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003732	003003732	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4285
# text = Effects of diesel organic extracts on chemokine production by peripheral blood mononuclear cells.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	diesel	diesel	ADJ	JJ	Degree=Pos	_	_	_	_
4	organic	organic	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4286
# text = BACKGROUND: Polyaromatic hydrocarbons (PAHs) associated with diesel exhaust particles (DEPs) are found in the atmospheric urban pollution.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Polyaromatic	Polyaromatic	ADJ	JJ	Degree=Pos	_	_	_	_
4	hydrocarbons	hydrocarbon	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PAHs	PAH	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	diesel	diesel	NOUN	NN	Number=Sing	_	_	_	_
11	exhaust	exhaust	NOUN	NN	Number=Sing	_	_	_	_
12	particles	particle	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	DEPs	DEP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	atmospheric	atmospheric	ADJ	JJ	Degree=Pos	_	_	_	_
21	urban	urban	ADJ	JJ	Degree=Pos	_	_	_	_
22	pollution	pollution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4287
# text = Such compounds have been shown to favor IgE production, bronchial hyperresponsiveness, and airway inflammation.
1	Such	such	ADJ	JJ	Degree=Pos	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	favor	favor	VERB	VB	VerbForm=Inf	_	_	_	_
8	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
12	hyperresponsiveness	hyperresponsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
16	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4288
# text = Chemokines are a group of chemotactic cytokines involved in the recruitment of inflammatory cells.
1	Chemokines	Chemokine	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	group	group	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4289
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4290
# text = We investigated the effect of DEP-PAHs on the release and mRNA expression of IL-8, MCP-1, and RANTES by PBMCs obtained from healthy subjects.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	DEP	DEP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	PAHs	PAHs	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	release	release	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	RANTES	RANTES	PROPN	NNP	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	PBMCs	Pbmcs	PROPN	NNPS	Number=Plur	_	_	_	_
28	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
31	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4291
# text = METHODS: Protein production in supernatants was assessed by ELISA, and mRNA expression was evaluated by semiquantitative RT-PCR.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Protein	protein	PROPN	NNP	Number=Sing	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
19	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4292
# text = RESULTS: Secretion of IL-8 and RANTES increased in a dose-dependent manner with increasing concentrations of DEP-PAHs (range, 0.5 ng to 50 ng/mL).
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Secretion	Secretion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	8	8	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	RANTES	RANTES	PROPN	NNP	Number=Sing	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	SCONJ	IN	_	_	_	_	_
18	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
19	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	DEP	DEP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	PAHs	PAHs	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	range	range	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
28	ng	ng	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	50	50	NUM	CD	NumType=Card	_	_	_	_
31	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	mL	mL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4293
# text = On the contrary, the release of MCP-1 was significantly inhibited, also in a dose-dependent manner.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	release	release	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	significantly	significantly	ADV	RB	_	_	_	_	_
13	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4294
# text = Messenger RNA production coding for IL-8, RANTES, and MCP-1 showed parallel variations to the production of the correspondent proteins.
1	Messenger	Messenger	PROPN	NNP	Number=Sing	_	_	_	_
2	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
3	production	production	NOUN	NN	Number=Sing	_	_	_	_
4	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	RANTES	RANTES	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
18	variations	variation	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	correspondent	correspondent	ADJ	JJ	Degree=Pos	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4295
# text = Effects of DEP-PAHs became significant at 7 hours and up to 48 hours time culture for MCP-1, and up to 24 hours time culture for IL-8 and RANTES.
1	Effects	Effects	PROPN	NNPS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DEP	DEP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	PAHs	PAHs	PROPN	NNPS	Number=Plur	_	_	_	_
6	became	become	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	7	7	NUM	CD	NumType=Card	_	_	_	_
10	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	up	up	ADV	RB	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	48	48	NUM	CD	NumType=Card	_	_	_	_
15	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
16	time	time	NOUN	NN	Number=Sing	_	_	_	_
17	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	up	up	ADP	IN	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	24	24	NUM	CD	NumType=Card	_	_	_	_
27	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
28	time	time	NOUN	NN	Number=Sing	_	_	_	_
29	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	8	8	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	RANTES	RANTES	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4296
# text = Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	DEP	DEP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	PAH	PAH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	significantly	significantly	ADV	RB	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	significantly	significantly	ADV	RB	_	_	_	_	_
32	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	anti-IL	anti-il	SYM	$	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	8	8	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	anti-RANTES	anti-RANTES	NOUN	NNS	Number=Plur	_	_	_	_
41	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_
42	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4297
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4298
# text = These findings suggest that the chemokine pathways are modulated by DEP-PAHs at the transcriptional level, reinforcing the idea that the development of inflammatory reactions might be affected by diesel exhaust emission.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
7	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	DEP	DEP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	PAHs	PAHs	PROPN	NNPS	Number=Plur	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	reinforcing	reinforce	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	idea	idea	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	development	development	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	_
28	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	diesel	diesel	NOUN	NN	Number=Sing	_	_	_	_
33	exhaust	exhaust	NOUN	NN	Number=Sing	_	_	_	_
34	emission	emission	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4299
# text = Document 003003736 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003736	003003736	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4300
# text = Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-kappa B/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alfa (TNF-alpha) in human monocytes.
1	Acetylsalicylic	Acetylsalicylic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
5	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
6	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/c	/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
30	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	alfa	alfa	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
40	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4301
# text = We have investigated the effects of acetylsalicylic acid and sodium salicylate on the LPS-induced synthesis of the pro-coagulant protein tissue factor (TF) and the pro-inflammatory protein tumor necrosis factor-alpha (TNF-alpha), as well as the prostaglandin PGE2 in human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	acetylsalicylic	acetylsalicylic	ADJ	JJ	Degree=Pos	_	_	_	_
8	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
11	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	pro-coagulant	pro-coagulant	ADJ	JJ	Degree=Pos	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
32	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	as	as	ADV	RB	_	_	_	_	_
42	well	well	ADV	RB	Degree=Pos	_	_	_	_
43	as	as	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	prostaglandin	prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
46	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
49	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4302
# text = Both drugs dose-dependently inhibited LPS-induced TF and TNF-alpha synthesis at the mRNA and the protein level, and reduced PGE2 production.
1	Both	both	DET	DT	_	_	_	_	_
2	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
3	dose	dose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	dependently	dependently	ADV	RB	_	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	PGE2	Pge2	NUM	CD	NumType=Card	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4303
# text = As evidenced by electro mobility shift assay (EMSA) and the use of a NF-kappa B prototypic probe, these drugs probably exert their inhibitory effects by interference with the nuclear translocation of NF-kappa B/c-Rel proteins.
1	As	as	SCONJ	IN	_	_	_	_	_
2	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	electro	electro	NUM	CD	NumType=Card	_	_	_	_
5	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
6	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
7	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	use	use	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	prototypic	prototypic	ADJ	JJ	Degree=Pos	_	_	_	_
21	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
25	probably	probably	ADV	RB	_	_	_	_	_
26	exert	exert	ADP	IN	Typo=Yes	_	_	_	_
27	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
29	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	/c	/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
44	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4304
# text = These data may expand the understanding of the anti-thrombotic and anti-inflammatory effects of these drugs when activation of monocytes occurs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	expand	expand	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	anti-thrombotic	anti-thrombotic	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4305
# text = Document 003003741 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003741	003003741	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4306
# text = HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity.
1	HLA	Hla	ADJ	JJ	Degree=Pos	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
10	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
11	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
12	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	F	F	PROPN	NNP	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4307
# text = Chronic rejection of transplanted organs is manifested as atherosclerosis of the blood vessels of the allograft.
1	Chronic	Chronic	ADJ	JJ	Degree=Pos	_	_	_	_
2	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transplanted	transplant	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	organs	organ	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	manifested	manifested	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	vessels	vessel	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	allograft	allograft	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4308
# text = HLA class I Ags have been implicated to play a major role in this process, since signaling via HLA class I molecules can induce the proliferation of aortic endothelial as well as smooth muscle cells.
1	HLA	Hla	ADJ	JJ	Degree=Pos	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	Ags	ag	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	since	since	SCONJ	IN	_	_	_	_	_
18	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
21	class	class	NOUN	NN	Number=Sing	_	_	_	_
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
30	endothelial	endothelial	NOUN	NN	Number=Sing	_	_	_	_
31	as	as	ADV	RB	_	_	_	_	_
32	well	well	ADV	RB	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	smooth	smooth	ADJ	JJ	Degree=Pos	_	_	_	_
35	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4309
# text = In this study, we show that HLA class I-mediated induction of cell proliferation correlates with inactivation of the Rb protein in the T cell line Jurkat as well as human aortic endothelial cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
17	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	as	as	ADV	RB	_	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
35	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4310
# text = HLA class I-mediated inactivation of Rb can be inhibited specifically by neutralizing
1	HLA	Hla	ADJ	JJ	Degree=Pos	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 4311
# text = Abs to basic fibroblast growth factor (bFGF), suggesting a role for FGF receptors in the signaling process.
1	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
4	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	bFGF	bFGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	FGF	Fgf	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
20	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4312
# text = Signaling through HLA class I molecules induced cyclin E-associated kinase activity within 4 h in quiescent endothelial cells, and appeared to mediate the inactivation of Rb.
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
9	E-	E-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	h	h	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
18	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4313
# text = A cdk2 inhibitor, Olomoucine, as well as a dominant-negative cdk2 construct prevented HLA class I-mediated inactivation of Rb; in contrast, dominant-negative cdk4 and cdk6 constructs had no effect.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cdk2	cdk2	NOUN	NN	Number=Sing	_	_	_	_
3	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Olomoucine	Olomoucine	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dominant	dominant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	cdk2	cdk2	NOUN	NN	Number=Sing	_	_	_	_
15	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
16	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	HLA	Hla	PROPN	NNP	Number=Sing	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	;	;	PUNCT	,	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
32	cdk4	cdk4	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	cdk6	cdk6	NOUN	NN	Number=Sing	_	_	_	_
35	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
36	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	no	no	DET	DT	_	_	_	_	_
38	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4314
# text = Furthermore, there was no increase in cyclin D-associated kinase activity upon HLA class I ligation, suggesting that cyclin E-dependent kinase activity mediates
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	there	there	PRON	EX	_	_	_	_	_
4	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
9	D-	D-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	upon	upon	ADP	IN	_	_	_	_	_
14	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
15	class	class	NOUN	NN	Number=Sing	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
22	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 4315
# text = Rb inactivation, leading to E2F activation and cell proliferation.
1	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
2	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	F	F	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4316
# text = Document 003003746 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003746	003003746	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4317
# text = A conserved motif in the promoters of several cytokines expressed by human Th2-type lymphocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	conserved	conserve	ADJ	JJ	Degree=Pos	_	_	_	_
3	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	Th2	th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4318
# text = We have recently found a novel conserved motif in the promoters of several T-cell-expressed cytokines [human interleukin-2, -4, -5 and -13 and human and mouse granulocyte/macrophage-colony stimulating factor (GM-CSF)].
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	5	5	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	13	13	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	human	human	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
37	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
42	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4319
# text = It contains a core sequence CTTGG ... CCAAG which is present as part of larger palindromic sequences in each gene.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	core	core	NOUN	NN	Number=Sing	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	CTTGG	Cttgg	PROPN	NNP	Number=Sing	_	_	_	_
7	...	...	PUNCT	,	_	_	_	_	_
8	CCAAG	Ccaag	PROPN	NNP	Number=Sing	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	part	part	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	larger	larger	ADJ	JJR	Degree=Cmp	_	_	_	_
16	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
17	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	each	each	DET	DT	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4320
# text = This suggest that they may interact with a new family of trans-acting factors.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4321
# text = In transfection assays, the human GM-CSF element has a strong positive effect on the expression of a reporter gene by the human T cell line Jurkat J6 upon stimulation.
1	In	in	ADP	IN	_	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	Jurk	Jurk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	at	at	ADP	IN	_	_	_	_	_
31	J6	J6	PROPN	NNP	Number=Sing	_	_	_	_
32	upon	upon	ADP	IN	_	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4322
# text = In DNA mobility shift assays, this sequence can give either six different specific bands which are competed out by different parts of the sequence or one specific band which is competed out by each of the inverted repeats, depending on the reconstitution conditions.
1	In	in	ADP	IN	_	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	give	give	VERB	VB	VerbForm=Inf	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	six	six	NUM	CD	NumType=Card	_	_	_	_
13	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	competed	compet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	out	out	ADP	RP	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	parts	part	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	one	one	NUM	CD	NumType=Card	_	_	_	_
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	band	band	NOUN	NN	Number=Sing	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	competed	compet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	out	out	ADP	RP	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	each	each	DET	DT	_	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	inverted	invert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	_
45	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4323
# text = In different genes, the core sequences are separated by integer numbers of helical turns.
1	In	in	ADP	IN	_	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	core	core	NOUN	NN	Number=Sing	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	integer	integer	NOUN	NN	Number=Sing	_	_	_	_
12	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	helical	helical	ADJ	JJ	Degree=Pos	_	_	_	_
15	turns	turn	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4324
# text = Considering the strong positive regulatory effect of this element and its presence in several T-cell-expressed cytokine genes, it may be crucial to the coordinated expression of these cytokines in T helper cells.
1	Considering	consider	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
12	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	T	T	PROPN	NNP	Number=Sing	_	_	_	_
36	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4325
# text = Document 003003751 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003751	003003751	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4326
# text = Human immunodeficiency viruses containing heterologous enhancer/promoters are replication competent and exhibit different lymphocyte tropisms.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
11	competent	competent	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	exhibit	exhibit	ADJ	JJ	Degree=Pos	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
16	tropisms	tropism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4327
# text = The human immunodeficiency virus (HIV) type 1 long terminal repeat (LTR) contains binding sites for nuclear factor kappa B (NF-kappa B) and the constitutively expressed transcription factor Sp1, both of which are highly conserved in HIV and simian immunodeficiency virus isolates.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	constitutively	constitutively	ADV	RB	_	_	_	_	_
33	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	both	both	DET	DT	_	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	which	which	PRON	WDT	PronType=Rel	_	_	_	_
41	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
42	highly	highly	ADV	RB	_	_	_	_	_
43	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
48	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
49	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
50	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4328
# text = To delineate the effects of these motifs on the replicative capacity of HIV and to explore the possibility of extending the virus host range, known heterologous enhancer/promoters were inserted into the HIV-1 LTR in place of the NF-kappa B and Sp1 binding sites.
1	To	to	PART	TO	_	_	_	_	_
2	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
11	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
23	host	host	NOUN	NN	Number=Sing	_	_	_	_
24	range	range	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	inserted	insert	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	into	into	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	place	place	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
46	B	b	PROPN	NNP	Number=Sing	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
49	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
50	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4329
# text = The effects of these substitutions on viral replication in transfected HeLa cells and on HIV infection of human peripheral blood lymphocytes or continuous T-leukemia cell lines were evaluated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
16	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
28	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4330
# text = HIVs in which the NF-kappa B/Sp1 enhancer plus the downstream TATA element were replaced with heterologous enhancer/promoters were also constructed.
1	HIVs	HIV	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	plus	plus	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
15	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4331
# text = Viruses containing the human cytomegalovirus immediate-early enhancer exhibited infectious kinetics similar to that of wild-type HIV in activated human peripheral blood lymphocytes and AA2 cells but replicated less efficiently in H9 and CEM cells.
1	Viruses	Viruse	NOUN	NNS	Number=Plur	_	_	_	_
2	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
6	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
12	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
13	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	HIV	Hiv	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	in	in	ADV	RB	_	_	_	_	_
22	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	AA2	AA2	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	replicated	replicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
33	efficiently	efficiently	ADV	RB	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	H9	H9	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4332
# text = These studies indicate that heterologous enhancer elements are capable of restoring
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	restoring	restore	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 4333
# text = Tat responsiveness to the HIV LTR in the context of directing reporter gene expression as well as in the production of infectious progeny virions.
1	Tat	Tat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
6	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	context	context	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
23	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
24	virions	virion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4334
# text = Document 003003752 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003752	003003752	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4335
# text = Naive (CD45RA+)
1	Naive	naive	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CD45RA	CD45RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	+)	+)	SYM	NFP	_	_	_	_	_

# sent_id = 4336
# text = T lymphocytes are more sensitive to oxidative stress-induced signals than memory (CD45RO+) cells.
1	T	t	NOUN	NN	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	more	more	ADV	RBR	_	_	_	_	_
5	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
8	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
12	than	than	ADP	IN	_	_	_	_	_
13	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CD45RO	Cd45ro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4337
# text = Formation of reactive oxygen intermediates (ROI) after oxidative stress has been shown to be an activation signal for T lymphocytes, e.g., expression of IL-2 and its receptor are induced.
1	Formation	Formation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
4	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
5	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ROI	ROI	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
11	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4338
# text = These ROI-induced effects can, to a large extent, be attributed to the activation of the transcription factor NF-kappaB.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	ROI	Roi	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
11	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4339
# text = Now we have examined whether naive and memory T lymphocytes differ in their sensitivity to ROI-mediated signals.
1	Now	now	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	memory	memory	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4340
# text = When CD45RA+ (naive) and CD45RO+ (memory)
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	CD45RA	CD45RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	+	+	SYM	SYM	_	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CD45RO	CD45RO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	memory	memory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 4341
# text = T lymphocytes were directly stimulated with H2O2, NF-kappaB nuclear translocation was stronger in naive cells than in memory cells and it could be induced with lower doses.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	directly	directly	ADV	RB	_	_	_	_	_
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	H2O2	H2O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
30	doses	dos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4342
# text = The composition of the induced nuclear NF-kappaB (levels of p50 and RelA proteins) was similar in these cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4343
# text = The magnitude and kinetics of intracellular
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 4344
# text = ROI were similar, suggesting that there were no differences in ROI-forming mechanisms or antioxidative capacities.
1	ROI	ROI	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	there	there	PRON	EX	_	_	_	_	_
8	were	be	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
15	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	antioxidative	antioxidative	ADJ	JJ	Degree=Pos	_	_	_	_
18	capacities	capacitie	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4345
# text = The probable regulatory point was the cytoplasmic IkappaB inhibitor: in CD45RA+ cells, H2O2 caused a more profound depression in the levels of IkappaB alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	probable	probable	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	point	point	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
8	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	CD45RA	CD45RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
17	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	more	more	ADV	RBR	_	_	_	_	_
20	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
21	depression	depression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4346
# text = These findings indicate that T cells representing different activation and/or differentiation stages can be differentially responsive to ROI-mediated signals.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	or	or	CCONJ	CC	_	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	differentially	differentially	ADV	RB	_	_	_	_	_
18	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4347
# text = Document 003003755 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003755	003003755	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4348
# text = Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	mediate	mediate	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
12	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4349
# text = Cells from the human monocytic leukemia cell line THP-1 differentiate towards a macrophage-like phenotype when stimulated with phorbol 12-myristate -13- acetate (PMA), 1,25-dihydroxy-vitamin D3, and various other agents.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	differentiate	differentiate	NOUN	NN	Number=Sing	_	_	_	_
13	towards	towards	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
18	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
26	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	_
28	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-dihydroxy-vitamin	-dihydroxy-vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
35	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
39	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
40	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4350
# text = We demonstrate here that the expression of the lysosomal enzyme acid sphingomyelinase (ASM; E.C.3.1.4.12) is induced during this process and is strongly elevated in differentiated THP-1 cells, as well as in differentiated human mononuclear phagocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
10	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
11	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
12	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	ASM	ASm	INTJ	UH	_	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	E.C.3.1.4.12	E.C.3.1.4.12	X	LS	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	process	process	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	strongly	strongly	ADV	RB	_	_	_	_	_
26	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	as	as	ADV	RB	_	_	_	_	_
35	well	well	ADV	RB	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	differentiated	differentiated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
40	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
41	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4351
# text = Using Northern blotting,
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
3	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 4352
# text = RNase protection assay, and nuclear run-on analyses, we show that the up-regulation of ASM expression is regulated mainly at the level of transcription and that new protein synthesis is required for enhanced ASM activity.
1	RNase	RNase	NOUN	NN	Number=Sing	_	_	_	_
2	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
3	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	on	on	ADP	IN	_	_	_	_	_
10	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	ASM	ASm	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	mainly	mainly	ADV	RB	_	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	level	level	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	ASM	ASm	ADJ	JJ	Degree=Pos	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4353
# text = This cell-type specific induction by PMA treatment was further investigated with respect to transcriptional control.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	further	further	ADV	RB	_	_	_	_	_
12	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4354
# text = A series of 5' deletion derivatives of the upstream regulatory region were used in transient transfection assays to identify promoter elements required for basal and inducible gene expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	series	series	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	'	'	PUNCT	``	_	_	_	_	_
6	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
7	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
18	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4355
# text = A PMA responsive element was localized to a region between -319 and -219 bp upstream of the initiation codon and co-transfections with transcription factor expression plasmids for AP-2 and Sp1 resulted in augmented ASM promoter activity, which was abolished when the binding sites for these two factors were deleted.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
3	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	319	319	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	219	219	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
21	codon	codon	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	co-transfections	co-transfection	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
35	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	ASM	ASm	NOUN	NN	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	which	which	PRON	WDT	PronType=Rel	_	_	_	_
43	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
44	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	when	when	ADV	WRB	PronType=Int	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
48	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
49	for	for	ADP	IN	_	_	_	_	_
50	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
51	two	two	NUM	CD	NumType=Card	_	_	_	_
52	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
53	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
54	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4356
# text = Using electrophoretic mobility shift assays and supershift assays we demonstrate that this region is specifically bound by Sp1 and AP-2.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
8	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	specifically	specifically	ADV	RB	_	_	_	_	_
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4357
# text = These factors are present in nuclear extracts prepared from both induced and uninduced THP-1 cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	uninduced	uninduced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4358
# text = However, the intensity of the complex formed appeared to increase when nuclear extracts from PMA-treated cells were used.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4359
# text = From these studies, we conclude that a concerted action of the transcription factors AP-2 and Sp1 is essential for the up -regulation of ASM expression during the process of macrophage differentiation.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	concerted	concerted	ADJ	JJ	Degree=Pos	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	up	up	NOUN	NN	Number=Sing	_	_	_	_
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ASM	ASm	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	during	during	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	process	process	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4360
# text = Document 003003757 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003757	003003757	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4361
# text = Glucocorticoid hormone suppression of human neutrophil-mediated tumor cell cytostasis.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
3	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	cytostasis	cytostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4362
# text = In the present study, we have investigated the effect of glucocorticoid hormones on neutrophil-mediated tumor cell cytostasis and found that hydrocortisone and a synthetic hormone, dexamethasone (Dex), inhibited cytostasis in the presence or absence of tumor necrosis factor-alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	cytostasis	cytostasis	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	hydrocortisone	hydrocortisone	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
28	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Dex	Dex	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	cytostasis	cytostasis	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
44	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4363
# text = The effect of Dex was completely reversed by a glucocorticoid receptor antagonist, RU38486.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Dex	Dex	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	completely	completely	ADV	RB	_	_	_	_	_
7	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	RU38486	RU38486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4364
# text = To clarify the underlying mechanisms, we examined effects of Dex on the binding avidity of beta2 integrin on the neutrophil surface and how these might in turn affect neutrophil-to-tumor cell binding.
1	To	to	PART	TO	_	_	_	_	_
2	clarify	clarify	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Dex	Dex	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	avidity	avidity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
18	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	how	how	ADV	WRB	PronType=Int	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	might	might	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
29	affect	affect	NOUN	NN	Number=Sing	_	_	_	_
30	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4365
# text = Dex was found to inhibit these neutrophil properties, and RU38486 completely suppressed both forms of Dex inhibition.
1	Dex	Dex	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
8	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RU38486	RU38486	PROPN	NNP	Number=Sing	_	_	_	_
12	completely	completely	ADV	RB	_	_	_	_	_
13	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Dex	Dex	NOUN	NN	Number=Sing	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4366
# text = Taken together, our findings suggest that glucocorticoid hormone inhibition of neutrophil-mediated tumor cell cytostasis is at least partially due to a lowering of the ligand binding avidity of beta2 integrin on the neutrophil surface.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	cytostasis	cytostasis	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	at	at	ADV	RB	_	_	_	_	_
20	least	least	ADV	RBS	Degree=Sup	_	_	_	_
21	partially	partially	ADV	RB	_	_	_	_	_
22	due	due	ADP	IN	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	lowering	lowering	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	avidity	avidity	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
33	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
37	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4367
# text = Document 003003759 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003759	003003759	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4368
# text = Induction of vascular cell adhesion molecule-1 by low-density lipoprotein.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	density	density	NOUN	NN	Number=Sing	_	_	_	_
13	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4369
# text = Low-density lipoprotein (LDL) is a well-established risk factor for atherosclerosis.
1	Low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	density	density	NOUN	NN	Number=Sing	_	_	_	_
4	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4370
# text = When endothelial cells are incubated with this lipoprotein in pathophysiologic amounts, the cells are activated.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	pathophysiologic	pathophysiologic	ADJ	JJ	Degree=Pos	_	_	_	_
11	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4371
# text = Among the documented cellular responses to LDL is increased recruitment of monocytes, which are believed to play a major role in promoting intimal plaque formation.
1	Among	among	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
24	intimal	intimal	ADJ	JJ	Degree=Pos	_	_	_	_
25	plaque	plaque	NOUN	NN	Number=Sing	_	_	_	_
26	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4372
# text = The findings presented here link an atheogenic lipoprotein, LDL, with the induction of an adhesion molecule important in atherogenesis Human LDL induces the vascular cell adhesion molecule-1 (VCAM-1) transcriptionally with an increase in mRNA levels through activation of the VCAM promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	link	link	NOUN	NN	Number=Sing	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	atheogenic	atheogenic	ADJ	JJ	Degree=Pos	_	_	_	_
8	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	LDL	LDL	INTJ	UH	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	atherogenesis	atherogenesis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	Human	Human	PROPN	NNP	Number=Sing	_	_	_	_
23	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
24	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
29	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
43	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
44	through	through	ADP	IN	_	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	VCAM	VCAm	PROPN	NNP	Number=Sing	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4373
# text = This effect is blocked by anti-VCAM antibodies.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	anti-VCAM	anti-vcam	ADJ	JJ	Degree=Pos	_	_	_	_
7	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4374
# text = After a 2-day incubation in LDL, the binding of NF-kappa B, which is believed to be a key oxidative-stress sensor for VCAM regulation, remains at basal level.
1	After	after	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	day	day	NOUN	NN	Number=Sing	_	_	_	_
6	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
25	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
28	sensor	sensor	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	VCAM	Vcam	PROPN	NNP	Number=Sing	_	_	_	_
31	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
36	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4375
# text = In contrast, the binding activities of AP-1 and GATA, on the other hand, are increased by LDL.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4376
# text = Thus, a component of LDL-enhanced endothelial recruitment of monocytes is attributed to VCAM-1 expression, which appears to be mediated through AP-1 and GATA.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	component	component	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4377
# text = These data identify LDL as a VCAM-inducer possibly distinct from cytokines and endotoxin.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	identify	identify	NOUN	NN	Number=Sing	_	_	_	_
4	LDL	LDL	NOUN	NN	Number=Sing	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
10	possibly	possibly	ADV	RB	_	_	_	_	_
11	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4378
# text = Document 003003760 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003760	003003760	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4379
# text = p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells.
1	p38	p38	NUM	CD	NumType=Card	_	_	_	_
2	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
9	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TCR/CD28	TCR/CD28	NUM	CD	NumType=Card	_	_	_	_
12	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4380
# text = Optimal T cell activation requires two signals, one generated by TCR and another by the CD28 costimulatory receptor.
1	Optimal	optimal	PROPN	NNP	Number=Sing	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	one	one	NUM	CD	NumType=Card	_	_	_	_
10	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	another	another	DET	DT	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
18	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4381
# text = In this study, we investigated the regulation of costimulation-induced mitogen-activated protein kinase (MAPK) activation in primary mouse T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4382
# text = In contrast to that reported for human Jurkat T cells, we found that p38 MAPK, but not Jun NH2-terminal kinase (JNK), is weakly activated upon stimulation with either anti-CD3 or anti-CD28 in murine thymocytes and splenic T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	p38	p38	PROPN	NNP	Number=Sing	_	_	_	_
16	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
21	NH2	NH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	weakly	weakly	ADV	RB	_	_	_	_	_
31	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	upon	upon	ADP	IN	_	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	either	either	CCONJ	CC	_	_	_	_	_
36	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
41	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4383
# text = However, p38 MAPK is activated strongly and synergistically by either CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28-mediated signaling.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	p38	p38	NUM	CD	NumType=Card	_	_	_	_
4	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	strongly	strongly	ADV	RB	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	synergistically	synergistically	ADV	RB	_	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	either	either	DET	DT	_	_	_	_	_
12	CD3/CD28	CD3/CD28	NOUN	NN	Number=Sing	_	_	_	_
13	coligation	coligation	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	+	+	SYM	SYM	_	_	_	_	_
19	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	_
20	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	mimics	mimics	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	TCR-CD3/CD28-mediated	TCR-CD3/CD28-mediate	ADJ	JJ	Degree=Pos	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4384
# text = Activation of p38 MAPK correlates closely with the stimulation of T cell proliferation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	p38	p38	NUM	CD	NumType=Card	_	_	_	_
4	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
5	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	closely	closely	ADV	RB	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4385
# text = In contrast, PMA-induced JNK activation is inhibited by Ca2+ ionophore.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	ionophore	ionophore	ADV	RB	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4386
# text = T cell proliferation and production of IL-2, IL-4, and IFN-gamma induced by both CD3 and CD3/CD28 ligation and the nuclear expression of the c-Jun and ATF-2 proteins are each blocked by the p38 MAPK inhibitor SB203580.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IFN	IFN	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	CD3/CD28	Cd3/cd28	NOUN	NN	Number=Sing	_	_	_	_
25	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
40	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	each	each	DET	DT	_	_	_	_	_
42	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	p38	p38	PROPN	NNP	Number=Sing	_	_	_	_
46	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
47	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
48	SB	Sb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	203580	203580	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4387
# text = Our findings demonstrate that p38 MAPK
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	p38	p38	NUM	CD	NumType=Card	_	_	_	_
6	MAPK	Mapk	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4388
# text = 1) plays an important role in signal integration during costimulation of primary mouse T cells, 2) may be involved in the induction of c-Jun activation and augmentation of AP-1 transcriptional activity, and 3) regulates whether T cells enter a state of functional unresponsiveness.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
9	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
14	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	2	2	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	augmentation	augmentation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	3	3	X	LS	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	whether	whether	SCONJ	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
47	enter	enter	VERB	VB	VerbForm=Inf	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	state	state	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
52	unresponsiveness	unresponsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4389
# text = Document 003003761 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003761	003003761	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4390
# text = The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	p65	p65	NUM	CD	NumType=Card	_	_	_	_
3	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4391
# text = Transcription factor NF-kappa B (p50/p65) is generally localized to the cytoplasm by its inhibitor
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
10	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	generally	generally	ADV	RB	_	_	_	_	_
14	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
20	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4392
# text = I kappa B.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4393
# text = Overproduced I kappa B, free from NF-kappa B, is rapidly degraded.
1	Overproduced	Overproduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
4	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	rapidly	rapidly	ADV	RB	_	_	_	_	_
15	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4394
# text = Overexpression of p65 increases endogenous I kappa B protein in both carcinoma and lymphoid cells by two mechanisms: protein stabilization and increased transcription of I kappa B mRNA.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	p65	p65	NUM	CD	NumType=Card	_	_	_	_
4	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
5	endogenous	endogenous	CCONJ	CC	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	B	PROPN	NNP	Number=Sing	_	_	_	_
29	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4395
# text = In contrast, p65 delta, a naturally occurring splice variant, fails to markedly augment I kappa B protein levels.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	p65	p65	NUM	CD	NumType=Card	_	_	_	_
5	delta	delta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	naturally	naturally	ADV	RB	_	_	_	_	_
9	occurring	occurre	ADJ	JJ	Degree=Pos	_	_	_	_
10	splice	splice	NOUN	NN	Number=Sing	_	_	_	_
11	variant	variant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	markedly	markedly	ADV	RB	_	_	_	_	_
16	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4396
# text = Both overexpressed p65 and coexpressed p50 are cytoplasmic, whereas p65 delta is partly nuclear, indicating that the I kappa B induced by p65 can maintain NF-kappa B in the cytoplasm.
1	Both	both	DET	DT	_	_	_	_	_
2	overexpressed	overexpressed	ADJ	JJ	Degree=Pos	_	_	_	_
3	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	whereas	whereas	SCONJ	IN	_	_	_	_	_
11	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
12	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	partly	partly	ADV	RB	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
26	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
27	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4397
# text = Thus, p65 and I kappa B are linked in an autoregulatory loop, ensuring that NF-kappa B is held in the cytoplasm until cells are specifically induced to translocate it to the nucleus.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	p65	p65	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	ensuring	ensure	VERB	VBG	VerbForm=Ger	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	held	hold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
26	until	until	SCONJ	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	specifically	specifically	ADV	RB	_	_	_	_	_
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	translocate	translocate	VERB	VB	VerbForm=Inf	_	_	_	_
33	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4398
# text = Document 003003763 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003763	003003763	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4399
# text = Mononuclear leukocyte glucocorticoid receptor binding characteristics and down-regulation in major depression.
1	Mononuclear	Mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
3	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
13	depression	depression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4400
# text = Some patients with major depressive disorder (MDD) have elevated plasma cortisol concentrations and show failure to suppress cortisol secretion upon administration of dexamethasone (DEX), yet they do not have Cushingoid features.
1	Some	some	DET	DT	_	_	_	_	_
2	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	depressive	depressive	ADJ	JJ	Degree=Pos	_	_	_	_
6	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MDD	MDD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
13	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
14	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
17	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
20	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
21	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
22	upon	upon	ADP	IN	_	_	_	_	_
23	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	yet	yet	CCONJ	CC	_	_	_	_	_
31	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
32	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
35	Cushingoid	Cushingoid	ADJ	JJ	Degree=Pos	_	_	_	_
36	features	feature	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4401
# text = To study whether this represents glucocorticoid (GC) resistance, [3H]-DEX-binding assays were used to measure, in vitro, the GC receptor affinity (1/Kd) and number (Bmax) in mononuclear leukocytes of 11 MDD patients and 15 control subjects.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	glucocorticoid	glucocorticoid	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	3H	3H	INTJ	UH	_	_	_	_	SpaceAfter=No
14	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DEX	Dex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	measure	measure	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	1/	1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
34	Kd	kd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	number	number	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	Bmax	Bmax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
43	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	11	11	NUM	CD	NumType=Card	_	_	_	_
46	MDD	mdd	NOUN	NN	Number=Sing	_	_	_	_
47	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	15	15	NUM	CD	NumType=Card	_	_	_	_
50	control	control	NOUN	NN	Number=Sing	_	_	_	_
51	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4402
# text = No receptor abnormalities were detected in the MDD group; thus any cellular defect leading to a lack of responsiveness to GC in the MDD patients, if present, probably lies beyond the initial receptor binding.
1	No	no	DET	DT	_	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	MDD	mdd	PROPN	NNP	Number=Sing	_	_	_	_
9	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	thus	thus	ADV	RB	_	_	_	_	_
12	any	any	DET	DT	_	_	_	_	_
13	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
15	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	MDD	mdd	PROPN	NNP	Number=Sing	_	_	_	_
26	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	if	if	SCONJ	IN	_	_	_	_	_
29	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	probably	probably	ADV	RB	_	_	_	_	_
32	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	beyond	beyond	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4403
# text = DEX (1.0 mg orally) was administered to study in vivo GC receptor down-regulation.
1	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	1.0	1.0	NUM	CD	NumType=Card	_	_	_	_
4	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
5	orally	orally	ADV	RB	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	administered	administer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	GC	GC	NOUN	NN	Number=Sing	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4404
# text = Compared to the control group, fewer depressed subjects down-regulated Bmax after DEX.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	control	control	NOUN	NN	Number=Sing	_	_	_	_
5	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	fewer	fewer	NOUN	NN	Number=Sing	_	_	_	_
8	depressed	depress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
10	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	Bmax	Bmax	PROPN	NNP	Number=Sing	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4405
# text = By paired t-test, Bmax decreased significantly in the control group but not in the depressed group.
1	By	by	ADP	IN	_	_	_	_	_
2	paired	paire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	t-	t-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	test	test	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Bmax	Bmax	PROPN	NNP	Number=Sing	_	_	_	_
7	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	control	control	NOUN	NN	Number=Sing	_	_	_	_
12	group	group	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	depressed	depress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4406
# text = Receptor number on the control day did not correlate significantly with the degree of receptor down-regulation, severity of depression or cortisol concentrations across all the subjects.
1	Receptor	Receptor	NOUN	NN	Number=Sing	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	control	control	NOUN	NN	Number=Sing	_	_	_	_
6	day	day	NOUN	NN	Number=Sing	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	severity	severity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	depression	depression	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
25	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
26	across	across	ADP	IN	_	_	_	_	_
27	all	all	DET	PDT	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4407
# text = These results do not lend support to previous reports suggesting that GC resistance in MDD results from a GC receptor-binding abnormality, and they emphasize the importance of considering receptor studies in the context of GC-mediated cell processes in order to identify the exact cellular defect(s) leading to GC resistance.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	lend	lend	VERB	VB	VerbForm=Inf	_	_	_	_
6	support	support	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
9	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
10	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
13	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	MDD	MDD	ADJ	JJ	Degree=Pos	_	_	_	_
16	results	result	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	abnormality	abnormality	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
27	emphasize	emphasize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	considering	consider	VERB	VBG	VerbForm=Ger	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
33	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	context	context	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	order	order	NOUN	NN	Number=Sing	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
49	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
50	defect	defect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	s	s	X	AFX	_	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
55	to	to	ADP	IN	_	_	_	_	_
56	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
57	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4408
# text = Document 003003765 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003765	003003765	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4409
# text = Cutting edge: expression of the NF of activated T cells in eosinophils: regulation by IL-4 and IL-5.
1	Cutting	cut	NOUN	NN	Number=Sing	_	_	_	_
2	edge	edge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4410
# text = We report that NF-AT1 and NF-AT4 are expressed cytoplasmically in resting eosinophils, whereas NF-AT2 and NF-AT3 have not been seen.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	AT1	AT1	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AT4	At4	PROPN	NNP	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	cytoplasmically	cytoplasmically	ADV	RB	_	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT2	At2	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	AT3	AT3	NOUN	NN	Number=Sing	_	_	_	_
26	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4411
# text = Likewise, NF-AT1 mRNA and NF-AT4 mRNA have been detected in resting eosinophils, and their levels can be significantly up-regulated by the Th2-associated cytokines IL-4 and IL-5.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	AT1	AT1	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AT4	AT4	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	significantly	significantly	ADV	RB	_	_	_	_	_
25	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	Th2	th2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
33	IL	IL	ADV	RB	_	_	_	_	SpaceAfter=No
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	4	4	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4412
# text = There is no detectable NF-AT protein expression in the nuclei of resting eosinophils.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	SCONJ	IN	_	_	_	_	_
14	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4413
# text = However NF-ATs appear in the nuclei of IL-4-, IL-5-, or ionomycin-stimulated eosinophils.
1	However	however	ADV	RB	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	ATs	ATs	PROPN	NNPS	Number=Plur	_	_	_	_
5	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	ionomycin-	ionomycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4414
# text = Only NF-AT1 and NF-AT4, but not NF-AT2 and NF-AT3, have translocated into the nuclei in IL-4- or IL-5-stimulated eosinophils.
1	Only	only	ADV	RB	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	AT1	AT1	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT4	AT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AT2	At2	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	AT3	AT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	into	into	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4415
# text = These findings delineate a novel pathway in the cytokine network in which Th2 lymphocytes "control" eosinophils via the release of IL-4 and IL-5, and activation of NF-AT in eosinophils.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	delineate	delineate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	network	network	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
16	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	"	"	PUNCT	''	_	_	_	_	_
18	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	release	release	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	AT	AT	ADP	IN	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4416
# text = The findings also suggest that a later feedback "talking" may exist between eosinophils and Th2 lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	later	later	ADV	RB	_	_	_	_	_
8	feedback	feedback	ADJ	JJ	Degree=Pos	_	_	_	_
9	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
10	talking	talk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	"	"	PUNCT	''	_	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4417
# text = Document 003003767 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003767	003003767	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4418
# text = Osteoclast markers accumulate on cells developing from human peripheral blood mononuclear precursors.
1	Osteoclast	Osteoclast	ADJ	JJ	Degree=Pos	_	_	_	_
2	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
3	accumulate	accumulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4419
# text = Recent studies show that human osteoclasts develop in vitro from hematopoietic cells; however, special cultures conditions and/or cytokine mobilized peripheral blood are apparently required.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	osteoclasts	osteoclast	NOUN	NNS	Number=Plur	_	_	_	_
7	develop	develop	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	special	special	ADJ	JJ	Degree=Pos	_	_	_	_
17	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
18	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	or	or	CCONJ	CC	_	_	_	_	_
22	cytokine	cytokine	PRON	PRP	_	_	_	_	_
23	mobilized	mobilize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	apparently	apparently	ADV	RB	_	_	_	_	_
28	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4420
# text = Here, we report that cells expressing osteoclast markers differentiate from precursors present in nonmobilized peripheral blood mononuclear cells (PBMC), without the addition of stromal cells, growth factors, cytokines or steroids; and characterize their phenotype.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
8	osteoclast	osteoclast	ADJ	JJ	Degree=Pos	_	_	_	_
9	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
10	differentiate	differentiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	nonmobilized	nonmobilize	ADJ	JJ	Degree=Pos	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	without	without	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	steroids	steroid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	characterize	characterize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
41	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4421
# text = Three days after establishing high-density PBMC cultures (1.5 x 10(6) cells/cm2), in serum-containing medium, small adherent colonies of tartrate resistant acid phosphatase positive (TRAP+) cells emerge, amidst massive monocyte cell death.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	days	day	NOUN	NNS	Number=Plur	_	_	_	_
3	after	after	SCONJ	IN	_	_	_	_	_
4	establishing	establish	VERB	VBG	VerbForm=Ger	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	density	density	NOUN	NN	Number=Sing	_	_	_	_
8	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
9	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	1.5	1.5	NUM	CD	NumType=Card	_	_	_	_
12	x	x	SYM	SYM	_	_	_	_	_
13	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	cm2	cm2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	serum-	serum-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
25	medium	medium	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
28	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
29	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	tartrate	tartrate	ADJ	JJ	Degree=Pos	_	_	_	_
32	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
33	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
34	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
35	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TRAP	trap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	emerge	emerge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	amidst	amidst	ADJ	JJS	Degree=Sup	_	_	_	_
44	massive	massive	ADJ	JJ	Degree=Pos	_	_	_	_
45	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4422
# text = These adherent cells have an eccentrically placed, round nucleus, and express low levels of TRAP and sodium fluoride-resistant- alpha-naphthyl-acetate-esterase (NaF-R-NSE).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	eccentrically	eccentrically	ADV	RB	_	_	_	_	_
7	placed	placed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	round	round	ADJ	JJ	Degree=Pos	_	_	_	_
10	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
14	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TRAP	trap	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
20	fluoride	fluoride	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	naphthyl-acetate-esterase	naphthyl-acetate-esterase	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NaF	NaF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	NSE	NSE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4423
# text = Over the next week, this cell population accumulates phenotypic markers of osteoclasts (vitronectin receptor [VR], calcitonin receptor, TRAP, cathepsin K protein, and mRNA) with increased nuclearity, covering the entire surface by 15 days.
1	Over	over	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	next	next	ADJ	JJ	Degree=Pos	_	_	_	_
4	week	week	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	population	population	NOUN	NN	Number=Sing	_	_	_	_
9	accumulates	accumulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
11	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	osteoclasts	osteoclast	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	vitronectin	vitronectin	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	VR	VR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	calcitonin	calcitonin	ADP	IN	_	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	TRAP	trap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	cathepsin	cathepsin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
27	K	k	NUM	CD	NumType=Card	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	mRNA	mRNA	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	nuclearity	nuclearity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	covering	cover	VERB	VBG	VerbForm=Ger	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
40	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	15	15	NUM	CD	NumType=Card	_	_	_	_
43	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4424
# text = When cultured on bone, VR+, TRAP+ cells of low multinuclearity appear and cover up to 50% of the surface.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	bone	bone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	VR	VR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	TRAP	trap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	multinuclearity	multinuclearity	NOUN	NN	Number=Sing	_	_	_	_
15	appear	appear	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	cover	cover	VERB	VB	VerbForm=Inf	_	_	_	_
18	up	up	ADP	RP	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4425
# text = Resorption lacunae can be observed by day 22.
1	Resorption	Resorption	NOUN	NN	Number=Sing	_	_	_	_
2	lacunae	lacuna	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	day	day	NOUN	NN	Number=Sing	_	_	_	_
8	22	22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4426
# text = Although these pits are not nearly as numerous as the cells of preosteoclast phenotype, they do represent the activity of a subset of osteoclast-like cells that has achieved osteoclastic maturity under these culture conditions.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	pits	pit	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	nearly	nearly	ADV	RB	_	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	preosteoclast	preosteoclast	ADJ	JJ	Degree=Pos	_	_	_	_
14	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	osteoclast	osteoclast	ADV	RB	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	osteoclastic	osteoclastic	ADJ	JJ	Degree=Pos	_	_	_	_
33	maturity	maturity	NOUN	NN	Number=Sing	_	_	_	_
34	under	under	ADP	IN	_	_	_	_	_
35	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
36	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
37	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4427
# text = Transcripts for osteoprotegerin ligand (OPGL), an osteoclast differentiation factor (also known as RANKL and TRANCE) are expressed, likely by adherent cells.
1	Transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	osteoprotegerin	osteoprotegerin	ADJ	JJ	Degree=Pos	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	OPGL	OPGL	INTJ	UH	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	osteoclast	osteoclast	ADJ	JJ	Degree=Pos	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	also	also	ADV	RB	_	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	RANKL	Rankl	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	TRANCE	Trance	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	expressed	express	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4428
# text = Thus, an adherent population of cells, with preosteoclast/osteoclast phenotypic properties, arises selectively under simple culture conditions from normal PBMC.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
5	population	population	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	preosteoclast	preosteoclast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	osteoclast	osteoclast	ADJ	JJ	Degree=Pos	_	_	_	_
13	phenotypic	phenotypic	NOUN	NN	Number=Sing	_	_	_	_
14	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	arises	arise	NOUN	NNS	Number=Plur	_	_	_	_
17	selectively	selectively	ADV	RB	_	_	_	_	_
18	under	under	ADP	IN	_	_	_	_	_
19	simple	simple	ADJ	JJ	Degree=Pos	_	_	_	_
20	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
21	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4429
# text = Further characterization of these cells should identify factors involved in the growth, terminal differentiation and activation of osteoclasts.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
7	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	osteoclasts	osteoclast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4430
# text = Document 003003768 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003768	003003768	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4431
# text = Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.
1	Mutual	mutual	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
17	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
18	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4432
# text = The NK-kappa B transcription factor complex is sequestered in the cytoplasm by the inhibitory protein I kappa B-alpha (MAD-3).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	X	GW	_	_	_	_	_
20	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
21	alpha	alpha	X	GW	_	_	_	_	_
22	(	(	X	GW	_	_	_	_	SpaceAfter=No
23	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4433
# text = Various cellular stimuli relieve this inhibition by mechanisms largely unknown, leading to NF-kappa B nuclear localization and transactivation of its target genes.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
4	relieve	relieve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
9	largely	largely	ADV	RB	_	_	_	_	_
10	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4434
# text = It is demonstrated here with human T lymphocytes and monocytes that different stimuli, including tumor necrosis factor alpha and phorbol 12-myristate 13-acetate, cause rapid degradation of I kappa B-alpha, with concomitant activation of NF-kappa B, followed by a dramatic increase in
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
17	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
22	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
24	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
25	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
27	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	cause	cause	SCONJ	IN	_	_	_	_	_
30	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
31	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
51	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_

# sent_id = 4435
# text = I kappa B-alpha mRNA and protein synthesis.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
4	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4436
# text = Transfection studies reveal that the I kappa B-alpha mRNA and the encoded protein are potently induced by NF-kappa B and by homodimers of p65 and of c-Rel.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	encoded	encod	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	potently	potently	ADV	RB	_	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4437
# text = We propose a model in which NF-kappa B and I kappa B-alpha mutually regulate each other in a cycle: saturating amounts of the inhibitory I kappa B-alpha protein are destroyed upon stimulation, allowing rapid activation of NF-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	X	GW	_	_	_	_	_
14	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
15	alpha	alpha	X	GW	_	_	_	_	_
16	mutually	mutually	ADV	RB	_	_	_	_	_
17	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
18	each	each	DET	DT	_	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	saturating	saturat	VERB	VBG	VerbForm=Ger	_	_	_	_
25	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	kappa	kappa	X	GW	_	_	_	_	_
31	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
32	alpha	alpha	X	GW	_	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	destroyed	destroy	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	upon	upon	ADP	IN	_	_	_	_	_
37	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
40	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
46	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4438
# text = Subsequently, I kappa B-alpha mRNA and protein levels are quickly induced by the activated NF-kappa B.
1	Subsequently	subsequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
5	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
6	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
7	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	quickly	quickly	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4439
# text = This resurgence of I kappa B-alpha protein acts to restore an equilibrium in which NF-kappa B is again inhibited.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	resurgence	resurgence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
6	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	equilibrium	equilibrium	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	again	again	ADV	RB	_	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4440
# text = Document 003003773 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003773	003003773	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4441
# text = Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
5	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Duffy	Duffy	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Duffy	Duffy	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
19	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4442
# text = The mRNA for the Duffy blood group antigen, the erythrocyte receptor for the Plasmodium vivax malaria parasite, has recently been cloned and shown to encode a widely expressed chemokine receptor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Duffy	Duffy	PROPN	NNP	Number=Sing	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	group	group	NOUN	NN	Number=Sing	_	_	_	_
8	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	erythrocyte	erythrocyte	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Plasmodium	Plasmodium	PROPN	NNP	Number=Sing	_	_	_	_
16	vivax	vivax	NOUN	NN	Number=Sing	_	_	_	_
17	malaria	malaria	NOUN	NN	Number=Sing	_	_	_	_
18	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	recently	recently	ADV	RB	_	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	encode	encode	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	widely	widely	ADV	RB	_	_	_	_	_
30	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4443
# text = Here, we show that the Duffy antigen/chemokine receptor gene (DARC) is composed of a single exon and that most Duffy-negative blacks carry a silent FY*B allele with a single T to C substitution at nucleotide -46.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Duffy	Duffy	PROPN	NNP	Number=Sing	_	_	_	_
8	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	DARC	DARC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
21	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	most	most	ADV	RBS	_	_	_	_	_
25	Duffy	Duffy	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	blacks	black	NOUN	NNS	Number=Plur	_	_	_	_
29	carry	carry	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
32	FY	Fy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	*B	*b	NOUN	NN	Number=Sing	_	_	_	_
34	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	C	C	PROPN	NNP	Number=Sing	_	_	_	_
41	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
42	at	at	ADP	IN	_	_	_	_	_
43	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	46	46	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4444
# text = This mutation impairs the promoter activity in erythroid cells by disrupting a binding site for the GATA1 erythroid transcription factor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
3	impairs	impair	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	disrupting	disrupt	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	GATA1	GATA1	PROPN	NNP	Number=Sing	_	_	_	_
18	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4445
# text = With the recent characterization of the FY*A and FY*B alleles, these findings provide the molecular basis of the Duffy blood group system and an explanation for the erythroid-specific repression of the DARC gene in Duffy-negative individuals.
1	With	with	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
4	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	FY	FY	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	*A	*A	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	FY	FY	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	*B	*B	PROPN	NNP	Number=Sing	_	_	_	_
12	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
16	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
19	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Duffy	Duffy	PROPN	NNP	Number=Sing	_	_	_	_
23	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
24	group	group	NOUN	NN	Number=Sing	_	_	_	_
25	system	system	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	DARC	Darc	PROPN	NNP	Number=Sing	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	Duffy	Duffy	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
42	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4446
# text = Document 003003776 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003776	003003776	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4447
# text = The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
4	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
5	product	product	NOUN	NN	Number=Sing	_	_	_	_
6	represses	represse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-mediated	-mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4448
# text = The long terminal repeat (LTR) of the type 1 human immunodeficiency virus (HIV-1) and the 5' regulatory region of the gene encoding the interleukin 2 receptor alpha subunit (IL-2R alpha) share functional kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
3	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
4	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	'	'	PUNCT	``	_	_	_	_	_
24	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
35	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	share	share	NOUN	NN	Number=Sing	_	_	_	_
43	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4449
# text = B enhancer elements involved in the regulation of these inducible transcription units during T-cell activation.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	units	unit	NOUN	NNS	Number=Plur	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4450
# text = These kappa B enhancer elements are recognized by a structurally related family of interactive proteins that includes p50, p65, and the product of the c-rel protooncogene (c-Rel).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	structurally	structurally	ADV	RB	_	_	_	_	_
11	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	interactive	interactive	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	product	product	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
29	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4451
# text = Recent biochemical studies have shown that p65 and p50 form the prototypical NF-kappa B complex, which is rapidly translocated from the cytoplasm to the nucleus during T-cell activation.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	p50	p50	NUM	CD	NumType=Card	_	_	_	_
10	form	from	NOUN	NN	Number=Sing	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	prototypical	prototypical	ADJ	JJ	Degree=Pos	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	rapidly	rapidly	ADV	RB	_	_	_	_	_
22	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4452
# text = This intracellular signaling complex potently stimulates kappa B-directed transcription from either the HIV-1 LTR or the IL-2R alpha promoter via the strong transactivation domain present in p65.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
5	potently	potently	ADV	RB	_	_	_	_	_
6	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	via	via	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
29	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
30	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
31	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4453
# text = We now demonstrate that nuclear expression of human c-Rel, which is induced by either phorbol ester or tumor necrosis factor alpha with delayed kinetics relative to p65, markedly represses p65-mediated activation of these transcription units.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	either	either	DET	DT	_	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
26	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
27	relative	relative	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	markedly	markedly	ADV	RB	_	_	_	_	_
32	represses	repress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	units	unit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4454
# text = These inhibitory effects of c-Rel correlate with its DNA-binding activity but not with its ability to heterodimerize with p50, suggesting that c-Rel inhibition involves competition with p50/p65 for occupancy of the kappa B enhancer element.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
8	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	heterodimerize	heterodimerize	VERB	VB	VerbForm=Inf	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
30	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
31	involves	involves	NOUN	NNS	Number=Plur	_	_	_	_
32	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
44	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4455
# text = Together, these findings suggest that one function of c-Rel is as a physiologic repressor of the HIV-1 LTR and IL-2R alpha promoters, serving to efficiently counter the strong transcriptional activating effects of p65.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	function	function	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	serving	serve	VERB	VBG	VerbForm=Ger	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	efficiently	efficiently	ADV	RB	_	_	_	_	_
34	counter	counter	X	AFX	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
38	activating	activat	NOUN	NN	Number=Sing	_	_	_	_
39	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4456
# text = Document 003003779 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003779	003003779	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4457
# text = Activation of human immunodeficiency virus type 1 expression by Gardnerella vaginalis.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	Gardnerella	Gardnerella	PROPN	NNP	Number=Sing	_	_	_	_
11	vaginalis	vaginalis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4458
# text = Bacterial vaginosis (BV) is associated with an increased rate of sexual transmission of human immunodeficiency virus (HIV) type 1, and Gardnerella vaginalis is frequently isolated from the genital tracts of women with BV.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	vaginosis	vaginosis	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	BV	BV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	sexual	sexual	ADJ	JJ	Degree=Pos	_	_	_	_
14	transmission	transmission	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Gardnerella	Gardnerella	PROPN	NNP	Number=Sing	_	_	_	_
27	vaginalis	vaginalis	PROPN	NNP	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	frequently	frequently	ADV	RB	_	_	_	_	_
30	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	genital	genital	ADJ	JJ	Degree=Pos	_	_	_	_
34	tracts	tract	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	BV	BV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4459
# text = G. vaginalis lysates were found to significantly stimulate HIV expression in monocytoid cells.
1	G.	g.	PROPN	NNP	Number=Sing	_	_	_	_
2	vaginalis	vaginalis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	significantly	significantly	ADV	RB	_	_	_	_	_
8	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4460
# text = Stimulation was significantly higher when lysates were heated at 100 degrees C for 5 min but was reduced by treatment with lysozyme or protease.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	significantly	significantly	ADV	RB	_	_	_	_	_
4	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	heated	heat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	100	100	NUM	CD	NumType=Card	_	_	_	_
11	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
12	C	C	PROPN	NNP	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	_
15	min	min	NOUN	NNS	Number=Plur	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	lysozyme	lysozyme	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	protease	protease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4461
# text = G. vaginalis lysates also activated HIV expression in certain T cell lines.
1	G.	g.	PROPN	NNP	Number=Sing	_	_	_	_
2	vaginalis	vaginalis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4462
# text = G. vaginalis lysates activated HIV long-terminal repeat transcription in HIV-infected cells and increased NF-kappaB binding activity, indicating an effect by G. vaginalis on HIV transcription.
1	G.	G.	PROPN	NNP	Number=Sing	_	_	_	_
2	vaginalis	vaginalis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
6	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
9	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	G.	G.	PROPN	NNP	Number=Sing	_	_	_	_
28	vaginalis	vaginalis	PROPN	NNP	Number=Sing	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4463
# text = The activation of HIV production by G.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	G.	G.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4464
# text = vaginalis suggests that genital tract infection with G. vaginalis increases the risk of HIV transmission by increasing HIV expression in the genital tract.
1	vaginalis	vaginalis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	genital	genital	ADJ	JJ	Degree=Pos	_	_	_	_
5	tract	tract	NOUN	NN	Number=Sing	_	_	_	_
6	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	G.	G.	PROPN	NNP	Number=Sing	_	_	_	_
9	vaginalis	vaginalis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
15	transmission	transmission	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
18	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	genital	genital	ADJ	JJ	Degree=Pos	_	_	_	_
23	tract	tract	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4465
# text = This may explain, at least in part, the increased rate of HIV transmission in women with BV.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	at	at	ADV	RB	_	_	_	_	_
6	least	least	ADV	RBS	Degree=Sup	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
15	transmission	transmission	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	BV	BV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4466
# text = Document 0030013 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013	0030013	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4467
# text = Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	retroviral	retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
5	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	erythroblastic	erythroblastic	ADJ	JJ	Degree=Pos	_	_	_	_
9	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
13	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4468
# text = Targeted expression to specific tissues or cell lineages is a necessary feature of a gene therapy vector for many clinical applications, such as correction of hemoglobinopathies or thalassemias by transplantation of genetically modified hematopoietic stem cells.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
12	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
17	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
20	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
21	applications	application	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	correction	correction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	hemoglobinopathies	hemoglobinopathy	NOUN	NNS	Number=Plur	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	thalassemias	thalassemia	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	genetically	genetically	ADV	RB	_	_	_	_	_
34	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
36	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4469
# text = We developed retroviral vectors in which the constitutive viral enhancer in the U3 region of the 3' LTR is replaced by an autoregulatory enhancer of the erythroid-specific GATA-1 transcription factor gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	retroviral	retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
4	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	U3	U3	NUM	CD	NumType=Card	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	'	'	PUNCT	``	_	_	_	_	_
19	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4470
# text = The replaced enhancer is propagated to the 5' LTR upon integration into the target cell genome.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	propagated	propagate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	_
10	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	target	target	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4471
# text = The modified vectors were used to transduce human hematopoietic cell lines, cord blood-derived CD34(+) stem/progenitor cells, and murine bone marrow repopulating stem cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	modified	modified	ADJ	JJ	Degree=Pos	_	_	_	_
3	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	CD34	Cd34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	+)	+)	SYM	NFP	_	_	_	_	_
20	stem	stem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
27	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
28	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
29	repopulating	repopulat	VERB	VBG	VerbForm=Ger	_	_	_	_
30	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4472
# text = The expression of appropriate reporter genes (triangle upLNGFR, EGFP) was analyzed in the differentiated progeny of transduced stem cells in vitro, in liquid culture as well as in clonogenic assay, and in vivo, after bone marrow transplantation in lethally irradiated mice.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	triangle	triangle	NOUN	NN	Number=Sing	_	_	_	_
9	upLNGFR	upLNGFR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	EGFP	EGFP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	liquid	liquid	ADJ	JJ	Degree=Pos	_	_	_	_
28	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
29	as	as	ADV	RB	_	_	_	_	_
30	well	well	ADV	RB	Degree=Pos	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	clonogenic	clonogenic	ADJ	JJ	Degree=Pos	_	_	_	_
34	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	after	after	ADP	IN	_	_	_	_	_
41	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
42	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
43	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	lethally	lethally	ADV	RB	_	_	_	_	_
46	irradiated	irradiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4473
# text = The GATA-1 autoregulatory enhancer effectively restricts the expression of the LTR-driven proviral transcription unit to the erythroblastic progeny of both human progenitors and mouse-repopulating stem cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	autoregulatory	autoregulatory	NOUN	NN	Number=Sing	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	effectively	effectively	ADV	RB	_	_	_	_	_
8	restricts	restrict	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	unit	unit	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	erythroblastic	erythroblastic	ADJ	JJ	Degree=Pos	_	_	_	_
22	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	repopulating	repopulating	VERB	VBG	VerbForm=Ger	_	_	_	_
31	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4474
# text = Packaging of viral particles, integration into the target genome, and stability of the integrated provirus are not affected by the LTR modification.
1	Packaging	Packaging	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
4	particles	particle	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	target	target	NOUN	NN	Number=Sing	_	_	_	_
10	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	integrated	integrate	ADJ	JJ	Degree=Pos	_	_	_	_
17	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	_
24	modification	modification	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4475
# text = Enhancer replacement is therefore an effective strategy to target expression of a retroviral transgene to a specific progeny of transduced hematopoietic stem cells.
1	Enhancer	Enhancer	NOUN	NN	Number=Sing	_	_	_	_
2	replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	therefore	therefore	ADV	RB	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
7	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	retroviral	retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
14	transgene	transgene	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
22	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4476
# text = Document 00300110 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300110	00300110	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4477
# text = Four P-like elements are required for optimal transcription of the mouse IL-4 gene: involvement of a distinct set of nuclear factor of activated T cells and activator protein-1 family proteins.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	like	like	ADP	IN	_	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	set	set	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4478
# text = We previously identified the P sequence as a critical regulatory element of the human IL-4 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	P	p	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4479
# text = In the mouse IL-4 promoter, there are five elements homologous to the human P sequence designated conserved lymphokine element 0 (CLE0), P, P2, P3 and P4.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	there	there	PRON	EX	_	_	_	_	_
10	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	five	five	NUM	CD	NumType=Card	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	0	0	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	P	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	P2	p2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	P3	P3	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	P4	p4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4480
# text = To characterize the role of these P-like elements and their binding factors in the native promoter, we did transient transfection and electrophoretic mobility shift assays (EMSA).
1	To	to	PART	TO	_	_	_	_	_
2	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	like	like	ADP	IN	_	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
22	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4481
# text = Transfection of EL-4 cells with the IL-4 promoter-reporter constructs carrying mutated P-like elements showed that four P-like elements, CLE0, P, P2 and P4, but not P3, were required for optimal activation of the IL-4 promoter.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	EL	EL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
16	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
17	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	like	like	ADP	IN	_	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	four	four	NUM	CD	NumType=Card	_	_	_	_
24	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	P	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	P2	P2	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	P4	P4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	P3	P3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	4	4	NUM	CD	NumType=Card	_	_	_	_
51	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4482
# text = EMSA showed that both constitutive and inducible complexes bound to CLE0, P, P2 and P4, whereas only a constitutive complex bound to P3.
1	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
2	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	P	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	P2	P2	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	P4	P4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	P3	P3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4483
# text = In competition and antibody supershift assays in EMSA, complexes formed with P or P2 proved to contain nuclear factor of activated T cells (NFAT) family proteins as major components.
1	In	in	ADP	IN	_	_	_	_	_
2	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
5	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
6	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
11	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	P	p	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	P2	p2	NOUN	NN	Number=Sing	_	_	_	_
16	proved	prove	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
32	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4484
# text = Activator protein (AP)-1 family proteins interacted with CLE0, P, P2 and P4. NFAT
1	Activator	Activator	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	interacted	interact	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	P2	p2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	P4	p4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 4485
# text = /AP-1 complex formed only with P and P2.
1	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	P	p	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	P2	p2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4486
# text = Cross-competition assays among the P-like elements revealed element-specific and common complexes.
1	Cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-competition	-competition	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	among	among	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	like	like	ADP	IN	_	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4487
# text = Six tandem repeats of the P element linked to the SV40 promoter responded to phorbol 12-myristate 13-acetate, while that of other elements did not.
1	Six	six	NUM	CD	NumType=Card	_	_	_	_
2	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
3	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	P	P	PROPN	NNP	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	while	while	SCONJ	IN	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4488
# text = It would thus appear that components of each P-like element-binding complexes are not identical and may coordinately contribute to transcriptional activity.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	components	component	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	each	each	DET	DT	_	_	_	_	_
9	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	like	like	ADP	IN	_	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	coordinately	coordinately	ADV	RB	_	_	_	_	_
21	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4489
# text = Document 00300116 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300116	00300116	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4490
# text = HIV enhancer activity perpetuated by NF-kappa B induction on infection of monocytes [see comments]
1	HIV	haHive	NOUN	NN	Number=Sing	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	perpetuated	perpetuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	see	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4491
# text = Permissiveness to replication of human immunodeficiency virus (HIV) differs in T lymphocytes and macrophages.
1	Permissiveness	Permissiveness	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4492
# text = In T cells, HIV transcription is poorly detected in vivo.
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	poorly	poorly	ADV	RB	_	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4493
# text = Cloned, normal T lymphocytes show very little, if any, basal activity of the HIV enhancer and low nuclear expression of NF-kappa B, a potent transcriptional activator of the HIV enhancer.
1	Cloned	Cloned	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	little	little	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	if	if	SCONJ	IN	_	_	_	_	_
11	any	any	DET	DT	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
31	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4494
# text = In contrast, fixed tissue macrophages express detectable HIV proteins, indicating permanent virus transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
6	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
7	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4495
# text = One explanation for the perpetuation of virus infection in macrophages could be sustained nuclear NF-kappa B expression.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	perpetuation	perpetuation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4496
# text = However, the U937 monocytic cell line, which is fully permissive to HIV replication, is known to express only low levels of nuclear NF-kappa B.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	fully	fully	ADV	RB	_	_	_	_	_
12	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4497
# text = We show here that chronic HIV infection results in both induction of a nuclear factor with antigenic properties indistinguishable from those of NF-kappa B and permanently increased HIV enhancer activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
19	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	permanently	permanently	ADV	RB	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4498
# text = This phenomenon, which is independent of tumour necrosis factor, is associated with HIV replication, and is thus likely to explain at least in part the perpetuation of HIV infection in monocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tumour	tumour	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
9	necrosis	necrosis	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	thus	thus	ADV	RB	_	_	_	_	_
21	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
24	at	at	ADV	RB	_	_	_	_	_
25	least	least	ADV	RBS	Degree=Sup	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	part	part	NOUN	NN	Number=Sing	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	perpetuation	perpetuation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
32	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4499
# text = Document 00300121 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300121	00300121	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4500
# text = Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	Oct-2	Oct-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
13	group	group	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
15	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4501
# text = The class II major histocompatibility complex gene HLA-DRA is expressed in B cells, activated T lymphocytes, and in antigen-presenting cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	presenting	presenting	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4502
# text = In addition, HLA-DRA gene expression is inducible in a variety of cell types by interferon-gamma (IFN-gamma).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	types	type	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4503
# text = Here we show that the lymphoid-specific transcription factor Oct-2A plays a critical role in HLA-DRA gene expression in class II-positive B cell lines, and that the high mobility group protein (HMG) I/Y binds to multiple sites within the DRA promoter, including the Oct-2A binding site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	A	a	NOUN	NN	Number=Sing	_	_	_	_
15	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	class	class	NOUN	NN	Number=Sing	_	_	_	_
27	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
38	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
39	group	group	NOUN	NN	Number=Sing	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	I/Y	I/y	DET	DT	_	_	_	_	_
45	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
48	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
49	within	within	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
60	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
61	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4504
# text = Coexpression of HMG I/Y and Oct-2 in cell lines lacking Oct-2 results in high levels of HLA-DRA gene expression, and in vitro DNA-binding studies reveal that HMG I/Y stimulates Oct-2A binding to the HLA-DRA promoter.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
4	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
13	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	results	result	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
34	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
37	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
38	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	A	a	NOUN	NN	Number=Sing	_	_	_	_
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	HLA	HLa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4505
# text = Thus, Oct-2A and HMG I/Y may synergize to activate HLA-DRA expression in B cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Oct-2A	Oct-2A	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
6	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	synergize	synergize	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	HLA	HLa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4506
# text = By contrast, Oct-2A is not involved in the IFN-gamma induction of the HLA-DRA gene in HeLa cells, but antisense HMG I/Y dramatically decreases the level of induction.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	A	a	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
29	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
30	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
31	dramatically	dramatically	ADV	RB	_	_	_	_	_
32	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4507
# text = We conclude that distinct sets of transcription factors are involved in the two modes of HLA-DRA expression, and that HMG I/Y may be important for B cell-specific expression, and is essential for IFN-gamma induction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	modes	mode	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
24	I/Y	I/Y	PROPN	NNP	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
42	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4508
# text = Document 00300130 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300130	00300130	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4509
# text = Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. B cell-specific transcriptional promoter activity mediated by the octamer motif requires the Oct1 or Oct2 protein and additional B cell-restricted cofactors.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
6	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
14	BOB.1/OBF.1	Bob.1/obf.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
27	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
28	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	Oct1	Oct1	NUM	CD	NumType=Card	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	cofactors	cofactor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4510
# text = One such cofactor, BOB.1/OBF.1, was recently isolated from human B cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	BOB.1/OBF.1	BOB.1/OBF.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	recently	recently	ADV	RB	_	_	_	_	_
9	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4511
# text = Here, we describe the isolation and detailed characterization of the murine homolog.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	detailed	detailed	ADJ	JJ	Degree=Pos	_	_	_	_
9	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
13	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4512
# text = Full-length cDNAs and genomic clones were isolated, and the gene structure was determined.
1	Full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	length	length	NOUN	NN	Number=Sing	_	_	_	_
4	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
7	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	determined	determin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4513
# text = Comparison of the deduced amino acids shows 88% sequence identity between mouse and human BOB.1/OBF.1. The NH2-terminal 126 amino acids of BOB.1/OBF.1 are both essential and sufficient for interaction with the POU domains of either Oct1 or Oct2.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	deduced	deduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
6	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
7	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	88	88	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	%	%	SYM	NN	Number=Sing	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	BOB.1/OBF.1	Bob.1/obf.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_
18	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NH2	Nh2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	126	126	NUM	CD	NumType=Card	_	_	_	_
23	amino	amino	DET	DT	_	_	_	_	_
24	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	BOB.1/OBF.1	Bob.1/obf.1	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	both	both	CCONJ	CC	_	_	_	_	_
29	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	POU	pou	NOUN	NN	Number=Sing	_	_	_	_
37	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	either	either	CCONJ	CC	_	_	_	_	_
40	Oct1	Oct1	NUM	CD	NumType=Card	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4514
# text = This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the Oct-DNA interaction reveals that binding of BOB.1/OBF.1 to Oct1 or Oct2 does not alter the interaction with DNA.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
10	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
20	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
27	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	BOB.1/OBF	BOB.1/OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.1	.1	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	Oct1	Oct1	NUM	CD	NumType=Card	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
37	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4515
# text = BOB.1/OBF.1 can efficiently activate octamer-dependent promoters in fibroblasts; however, it fails to stimulate octamer-dependent enhancer activity.
1	BOB.1/OBF	BOB.1/OBF	ADP	IN	_	_	_	_	SpaceAfter=No
2	.1	.1	NUM	CD	NumType=Card	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	efficiently	efficiently	ADV	RB	_	_	_	_	_
5	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
6	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
19	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4516
# text = Fusion of subdomains of BOB.1/OBF.1 with the GAL4 DNA binding domain reveals that both NH2- and COOH-terminal domains of BOB.1/OBF.1 contribute to full transactivation function, the COOH-terminal domain is more efficient in this transactivation assay.
1	Fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	subdomains	subdomain	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	BOB.1/OBF.1	BOB.1/OBF.1	PROPN	NNP	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	GAL4	Gal4	NOUN	NN	Number=Sing	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	COOH	COOh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
21	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	BOB.1/OBF	BOB.1/OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.1	.1	NUM	CD	NumType=Card	_	_	_	_
25	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
28	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
29	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	COOH	COOh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
35	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	more	more	ADV	RBR	_	_	_	_	_
38	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
41	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
42	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4517
# text = Consistent with the failure of full-length BOB.1/OBF.1 to stimulate octamer-dependent enhancer elements in non B cells, the GAL4 fusions likewise only stimulate from a promoter-proximal position.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	length	length	NOUN	NN	Number=Sing	_	_	_	_
9	BOB.1/OBF	Bob.1/obf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.1	.1	NUM	CD	NumType=Card	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	non	non	X	AFX	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	GAL4	GAL4	NOUN	NN	Number=Sing	_	_	_	_
25	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	_
26	likewise	likewise	ADV	RB	_	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	stimulate	stimulate	ADV	RB	Degree=Pos	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
34	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4518
# text = Document 00300132 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300132	00300132	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4519
# text = Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
16	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	INK4	INK4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
25	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4520
# text = The human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	causative	causative	ADJ	JJ	Degree=Pos	_	_	_	_
17	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
20	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4521
# text = Although the exact mechanism by which HTLV-I contributes to leukemogenesis is still unclear, the Tax protein is thought to play a major role in this process.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	leukemogenesis	leukemogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	still	still	ADV	RB	_	_	_	_	_
15	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4522
# text = This 40-kDa polypeptide is able to interact with the tumor suppressor p16(INK4A).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
5	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
13	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
14	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	INK4	INK4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4523
# text = Consequently, Tax can activate the signaling pathway that lead to the release of E2F that in turn induces expression of factors required for cell cycle progression.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	lead	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	release	release	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	F	F	PROPN	NNP	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
20	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
28	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4524
# text = In this paper, we demonstrate that Tax can also activate E2F-mediated transcription independently of p16(INK4A).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	E2F	E2f	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	independently	independently	ADV	RB	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	INK4	INK4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4525
# text = Indeed, when Tax is coexpressed with the E2F-1 transcription factor in CEM T-cells, which lack expression of p16(INK4A), it strongly potentiates the E2F-dependent activation of a reporter construct driven by a promoter containing E2F binding sites.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
16	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	INK4	INK4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
30	strongly	strongly	ADV	RB	_	_	_	_	_
31	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	E2F	E2f	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
41	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
45	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
46	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	F	F	SCONJ	IN	_	_	_	_	_
48	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
49	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4526
# text = This stimulation is abrogated by mutations affecting the E2F-binding sites.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
7	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4527
# text = In addition, Tax also stimulates the transcription of the E2F-1 gene itself.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4528
# text = Using Tax mutants that fail to activate either ATF- or NF-kappaB-dependent promoters and different 5' truncation mutants of the E2F-1 promoter, we show that the Tax-dependent transcriptional control of the E2F1 gene involves, at least in part, the ATF binding site located in the E2F-1 promoter.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	either	either	CCONJ	CC	_	_	_	_	_
9	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	''	_	_	_	_	_
22	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
23	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
39	control	control	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	E2F1	E2F1	PROPN	NNP	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	involves	involve	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	at	at	ADV	RB	_	_	_	_	_
47	least	least	ADV	RBS	Degree=Sup	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	ATF	Atf	SCONJ	IN	_	_	_	_	_
53	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
54	site	site	NOUN	NN	Number=Sing	_	_	_	_
55	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	E2F	E2F	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	1	1	NUM	CD	NumType=Card	_	_	_	_
61	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4529
# text = Document 00300138 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300138	00300138	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4530
# text = Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
10	promoter	promoter	ADV	RB	_	_	_	_	_
11	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	p65	p65	NUM	CD	NumType=Card	_	_	_	_
18	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4531
# text = Fas (CD95) and Fas ligand (CD95L) are an interacting receptor-ligand pair required for immune homeostasis.
1	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
7	ligand	ligand	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	CD95L	Cd95l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	interacting	interact	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
17	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4532
# text = Lymphocyte activation results in the upregulation of Fas expression and the acquisition of sensitivity to FasL-mediated apoptosis.
1	Lymphocyte	Lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	acquisition	acquisition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	FasL	FasL	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4533
# text = Although Fas upregulation is central to the preservation of immunologic tolerance, little is known about the molecular machinery underlying this process.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
3	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	preservation	preservation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
11	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	about	about	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
19	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	_
20	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4534
# text = To investigate the events involved in activation-induced Fas upregulation, we have examined mRNA accumulation, fas promoter activity, and protein expression in the Jurkat T-cell line treated with phorbol myristate acetate and ionomycin (P/I), pharmacological mimics of T-cell receptor activation.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	_
11	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
17	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	fas	fa	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
35	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
36	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	P/	Pith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
45	mimics	mimics	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4535
# text = Although resting Jurkat cells express Fas, Fas mRNA was induced approximately 10-fold in 2 h upon P/I stimulation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	_
19	upon	upon	ADP	IN	_	_	_	_	_
20	P/I	P/I	PROPN	NNP	Number=Sing	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4536
# text = Using sequential deletion mutants of the human fas promoter in transient transfection assays, we identified a 47-bp sequence (positions -306 to -260 relative to the ATG) required for activation-driven fas upregulation.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	sequential	sequential	ADJ	JJ	Degree=Pos	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	fas	fas	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
12	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
13	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	306	306	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	260	260	NUM	CD	NumType=Card	_	_	_	_
29	relative	relative	ADV	RB	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	ATG	ATG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	fas	fas	NOUN	NNS	Number=Plur	_	_	_	_
40	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4537
# text = Sequence analysis revealed the presence of a previously unrecognized composite binding site for both the Sp1 and NF-kappaB transcription factors at positions -295 to -286.
1	Sequence	Sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	previously	previously	ADV	RB	_	_	_	_	_
9	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
10	composite	composite	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	295	295	NUM	CD	NumType=Card	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	286	286	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4538
# text = Electrophoretic mobility shift assay (EMSA) and supershift analyses of this region documented constitutive binding of Sp1 in unactivated nuclear extracts and inducible binding of p50-p65 NF-kappaB heterodimers after P/I activation.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	supershift	supershift	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
10	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
16	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
25	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
34	after	after	ADP	IN	_	_	_	_	_
35	P/	p/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
37	activation	activation	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4539
# text = Sp1 and NF-kappaB transcription factor binding was shown to be mutually exclusive by EMSA displacement studies with purified recombinant Sp1 and recombinant p50.
1	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	mutually	mutually	ADV	RB	_	_	_	_	_
14	exclusive	exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
17	displacement	displacement	NOUN	NN	Number=Sing	_	_	_	_
18	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
22	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
25	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4540
# text = The functional contribution of the kappaB-Sp1 composite site in P/I-inducible fas promoter activation was verified by using kappaB-Sp1 concatamers (-295 to -286) in a thymidine kinase promoter-driven reporter construct and native promoter constructs in Jurkat cells overexpressing IkappaB-alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
9	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	P/I	P/I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	fas	fas	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	verified	verify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
24	concatamers	concatamer	NOUN	NNS	Number=Plur	_	_	_	_
25	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
26	295	295	NUM	CD	NumType=Card	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	286	286	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
34	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
39	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
47	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
48	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4541
# text = Site-directed mutagenesis of the critical guanine nucleotides in the kappaB-Sp1 element documented the essential role of this site in activation-dependent fas promoter induction.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
8	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
9	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	role	role	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	fas	fas	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4542
# text = Document 00300143 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300143	00300143	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4543
# text = HIV type 1 protease activation of NF-kappa B within T lymphoid cells.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4544
# text = NF-kappa B is a nuclear protein of the rel oncogene family capable of enhancing transcription of several cellular genes, including IL-2 and the IL-2 receptor, and viral genes transcribed from the HIV-1 LTR.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
12	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	SCONJ	IN	_	_	_	_	_
16	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
37	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4545
# text = It has been reported that HIV-1 protease may cleave the NF-kappa B precursor to its active form in vitro.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	cleave	cleave	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	form	form	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4546
# text = In this study the effects of HIV protease on NF-kappa B precursor activation were examined in Jurkat T cells by introducing a protease expression vector into the cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
8	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	introducing	introduce	VERB	VBG	VerbForm=Ger	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
28	into	into	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4547
# text = Increased NF-kappa B activity was observed and this increased activity was blocked by a specific inhibitor of the viral protease.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
22	protease	protease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4548
# text = Viral transcription, as measured using LTR-CAT assays, was only slightly enhanced in the HIV-protease expressing cells, while secretion of IL-2 and expression of the IL-2 receptor were not affected.
1	Viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	as	as	SCONJ	IN	_	_	_	_	_
5	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
10	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	slightly	slightly	ADV	RB	_	_	_	_	_
15	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV-	Hiv-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	while	while	SCONJ	IN	_	_	_	_	_
24	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4549
# text = The limited activation of NF-kappa B by HIV protease appears unlikely to have a significant effect on virus expression or T cell function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
11	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	unlikely	unlikely	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4550
# text = Document 00300144 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300144	00300144	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4551
# text = Nitric oxide decreases cytokine-induced endothelial activation.
1	Nitric	Nitric	PROPN	NNP	Number=Sing	_	_	_	_
2	oxide	oxide	ADV	RB	_	_	_	_	_
3	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4552
# text = Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.
1	Nitric	Nitric	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
3	selectively	selectively	ADV	RB	_	_	_	_	_
4	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4553
# text = To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated human saphenous vein endothelial cells with several NO donors and assessed their effects on the inducible expression of vascular cell adhesion molecule-1 (VCAM-1).
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
7	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NO	no	INTJ	UH	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	limits	limits	NOUN	NNS	Number=Plur	_	_	_	_
12	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	saphenous	saphenous	ADJ	JJ	Degree=Pos	_	_	_	_
22	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
23	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
27	NO	no	ADJ	JJ	Degree=Pos	_	_	_	_
28	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	assessed	assess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
33	on	on	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
41	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4554
# text = In a concentration-dependent manner, NO inhibited interleukin (IL)-1 alpha-stimulated VCAM-1 expression by 35-55% as determined by cell surface enzyme immunoassays and flow cytometry.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	NO	no	DET	DT	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	55	55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	as	as	SCONJ	IN	_	_	_	_	_
28	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
32	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
33	immunoassays	immunoassay	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	flow	flow	VERB	VB	VerbForm=Inf	_	_	_	_
36	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4555
# text = This inhibition was paralleled by reduced monocyte adhesion to endothelial monolayers in nonstatic assays, was unaffected by cGMP analogues, and was quantitatively similar after stimulation by either IL-1 alpha, IL-1 beta, IL-4, tumor necrosis factor (TNF alpha), or bacterial lipopolysaccharide.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	nonstatic	nonstatic	ADJ	JJ	Degree=Pos	_	_	_	_
14	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	cGMP	cgmp	NOUN	NN	Number=Sing	_	_	_	_
20	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	quantitatively	quantitatively	ADV	RB	_	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	either	either	CCONJ	CC	_	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
45	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
46	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
49	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	or	or	CCONJ	CC	_	_	_	_	_
53	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
54	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4556
# text = NO also decreased the endothelial expression of other leukocyte adhesion molecules (E-selectin and to a lesser extent, intercellular adhesion molecule-1) and secretable cytokines (IL-6 and IL-8).
1	NO	no	INTJ	UH	_	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
11	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
19	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
23	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	X	LS	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	secretable	secretable	ADJ	JJ	Degree=Pos	_	_	_	_
29	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	6	6	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4557
# text = Inhibition of endogenous NO production by L-N-monomethyl-arginine also induced the expression of VCAM-1, but did not augment cytokine-induced VCAM-1 expression.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	NO	no	DET	DT	_	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	L	L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	N-monomethyl	N-monomethyl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4558
# text = Nuclear run-on assays, transfection studies using various VCAM-1 promoter reporter gene constructs, and electrophoretic mobility shift assays indicated that NO represses VCAM-1 gene transcription, in part, by inhibiting NF-kappa B.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
8	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
9	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
10	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
11	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
21	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
22	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
23	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
24	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	NO	no	DET	DT	_	_	_	_	_
27	represses	repress	NOUN	NNS	Number=Plur	_	_	_	_
28	VCAM	VCAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	by	by	SCONJ	IN	_	_	_	_	_
38	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4559
# text = We propose that NO's ability to limit endothelial activation and inhibit monocyte adhesion may contribute to some of its antiatherogenic and antiinflammatory properties within the vessel wall.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NO	no	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	's	's	PART	POS	_	_	_	_	_
6	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	limit	limit	VERB	VB	VerbForm=Inf	_	_	_	_
9	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	some	some	DET	DT	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	antiatherogenic	antiatherogenic	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	vessel	vessel	NOUN	NN	Number=Sing	_	_	_	_
28	wall	wall	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4560
# text = Document 00300148 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300148	00300148	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4561
# text = Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells [see comments] BACKGROUND: Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis.
1	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
3	induce	induce	ADV	RB	_	_	_	_	_
4	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
5	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
16	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	see	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
26	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	:	:	PUNCT	:	_	_	_	_	_
28	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
31	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
32	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
35	role	role	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4562
# text = The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
7	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
23	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	X	LS	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4563
# text = METHODS AND RESULTS: Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM-1 were determined by ELISA and flow cytometry, respectively.
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Monolayers	Monolayer	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
9	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	nonstimulated	nonstimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	ADP	Adp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	flow	flow	VERB	VB	VerbForm=Inf	_	_	_	_
44	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4564
# text = In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P<0.02).
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	ADP	ADP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	significantly	significantly	ADV	RB	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	nonstimulated	nonstimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	0.02	0.02	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4565
# text = Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) determined by electrophoretic mobility shift assay and kappaB-dependent transcriptional activity was enhanced in the presence of activated platelets.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
17	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
18	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4566
# text = In addition, ADP-activated platelets induced MCP-1 and ICAM-1 promoter-dependent transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	ADP	Adp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	MCP	MCP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4567
# text = Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05).
1	Liposomal	Liposomal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
9	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
10	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4568
# text = CONCLUSIONS: The present study indicates that activated platelets modulate chemotactic (MCP-1) and adhesive (ICAM-1) properties of endothelial cells via an NF-kappaB-dependent mechanism.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	indicates	indicate	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
10	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	adhesive	adhesive	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	via	via	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4569
# text = Platelet-induced activation of the NF-kappaB system might contribute to early inflammatory events in atherogenesis.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	system	system	NOUN	NN	Number=Sing	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	events	event	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4570
# text = Document 00300151 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300151	00300151	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4571
# text = Decreased proteasome-mediated degradation in T cells from the elderly:
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	proteasome	proteasome	ADV	RB	_	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4572
# text = A role in immune senescence.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
5	senescence	senescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4573
# text = Induction of NFkappaB is a highly regulated process requiring phosphorylation, ubiquitination, and proteasome-mediated degradation of the cytosolic inhibitor IkappaBalpha.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	process	process	NOUN	NN	Number=Sing	_	_	_	_
9	requiring	require	VERB	VBG	VerbForm=Ger	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	ubiquitination	ubiquitination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	proteasome	proteasome	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
23	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4574
# text = Analyses of the regulation of IkappaBalpha in TNF-alpha-treated
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-alpha-treated	-alpha-treated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 4575
# text = T lymphocytes from young and elderly donors revealed severely compromised degradation of IkappaBalpha in T cells from the elderly.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
7	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
8	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	severely	severely	ADV	RB	_	_	_	_	_
10	compromised	compromise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	elderly	elderly	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4576
# text = Examination of activation-induced phosphorylation and ubiquitination of IkappaBalpha did not demonstrate any significant age-related alterations.
1	Examination	examination	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	ubiquitination	ubiquitination	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
14	any	any	DET	DT	_	_	_	_	_
15	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
16	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
19	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4577
# text = However, examination of proteasome activity in these T cells using fluorogenic peptide assays revealed a significant age-related decline in chymotryptic activity.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	examination	examination	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	fluorogenic	fluorogenic	ADJ	JJ	Degree=Pos	_	_	_	_
13	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
14	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
15	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
18	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
21	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	chymotryptic	chymotryptic	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4578
# text = These results suggest that a decline in proteasome activity results in a failure to fully degrade IkappaBalpha in the elderly.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	fully	fully	ADV	RB	_	_	_	_	_
16	degrade	degrade	VERB	VB	VerbForm=Inf	_	_	_	_
17	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	elderly	elderly	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4579
# text = This failure to degrade IkappaBalpha may underlie both the observed decrease in NFkappaB induction and the IL-2 receptor expression in TNF-treated T cells during aging.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	degrade	degrade	VERB	VB	VerbForm=Inf	_	_	_	_
5	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
11	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	during	during	ADP	IN	_	_	_	_	_
29	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4580
# text = Thus, decreased proteasome-mediated degradation may be central to immune dysfunction that accompanies aging.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	proteasome	proteasome	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
7	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	immune	immune	VERB	VB	VerbForm=Inf	_	_	_	_
13	dysfunction	dysfunction	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	accompanies	accompany	NOUN	NNS	Number=Plur	_	_	_	_
16	aging	age	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4581
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4582
# text = Document 00300152 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300152	00300152	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4583
# text = The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
8	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4584
# text = OBJECTIVES:
1	OBJECTIVES	objective	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4585
# text = To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines.
1	To	to	PART	TO	_	_	_	_	_
2	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4586
# text = DESIGN AND METHODS:
1	DESIGN	Design	NOUN	NN	Number=Sing	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4587
# text = The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	all	all	DET	DT	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
11	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	H9	H9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	monocytoid	monocytoid	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
30	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	during	during	ADP	IN	_	_	_	_	_
39	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
42	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4588
# text = The expression levels of human RAR alpha (hRAR alpha, receptor for all-trans RA) and the human retinoid-X receptor alpha (hRXR alpha receptor for 9-cis RA) were determined by Northern blot analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	RAR	RAR	NOUN	NN	Number=Sing	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	hRAR	hrar	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	all	all	DET	DT	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
17	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	X	x	NOUN	NN	Number=Sing	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	hRXR	hrxr	X	GW	_	_	_	_	_
29	alpha	alpha	X	GW	_	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
35	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
41	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
42	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4589
# text = RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells, in the presence and absence of the co-stimulatory agent phorbol myristate acetate (PMA).
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Both	both	DET	DT	_	_	_	_	_
4	all	all	DET	DT	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
11	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	IIIB	Iiib	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	monocytoid	monocytoid	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	co-stimulatory	co-stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
34	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
35	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
36	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4590
# text = The retinoids had weak or no stimulatory effects on HIV production by T-cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4591
# text = HIV production by PMA-stimulated T-cell lines was inhibited by these retinoids.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4592
# text = The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
5	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	generally	generally	ADV	RB	_	_	_	_	_
8	more	more	ADV	RBR	_	_	_	_	_
9	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
10	than	than	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
14	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
22	generally	generally	ADV	RB	_	_	_	_	_
23	more	more	ADV	RBR	_	_	_	_	_
24	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
28	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
29	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4593
# text = Human RAR alpha was expressed in H9, U937 and THP-1 cells, but almost undetectable in CEM cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	H9	H9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	U937	U937	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	almost	almost	ADV	RB	_	_	_	_	_
18	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4594
# text = Human RXR alpha was significantly expressed in U937 and THP-1 cells, weakly expressed in H9 cells and not detectable in CEM cells.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	RXR	Rxr	PROPN	NNP	Number=Sing	_	_	_	_
3	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	significantly	significantly	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	U937	U937	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	weakly	weakly	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	H9	H9	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4595
# text = After stimulation by PMA, RXR alpha expression increased in H9 and U937 cells but not in CEM cells.
1	After	after	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	RXR	RXR	X	GW	_	_	_	_	_
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	H9	H9	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	U937	U937	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4596
# text = Human RAR alpha expression was unchanged in H9 and CEM cells, and elevated in U937 cells, after PMA stimulation.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	unchanged	unchange	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	H9	H9	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	U937	U937	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4597
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 4598
# text = The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	partially	partially	ADV	RB	_	_	_	_	_
18	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4599
# text = Endogenous or exogenously administered RA may have a significant role in HIV regulation.
1	Endogenous	Endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	exogenously	exogenously	ADV	RB	_	_	_	_	_
4	administered	administer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4600
# text = Document 00300154 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300154	00300154	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4601
# text = The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	state	state	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
9	determines	determine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	13	13	NUM	CD	NumType=Card	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4602
# text = The molecular mechanisms of the effects of IL-4 and IL-13 on HIV infection in human monocytes as they matured into monocyte-derived macrophages over 7 days were investigated using HIV-1(BaL), and low passage clinical strains.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	13	13	NUM	CD	NumType=Card	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
23	matured	mature	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
29	over	over	ADP	IN	_	_	_	_	_
30	7	7	NUM	CD	NumType=Card	_	_	_	_
31	days	day	NOUN	NNS	Number=Plur	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
35	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	BaL	BaL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
44	passage	passage	NOUN	NN	Number=Sing	_	_	_	_
45	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
46	strains	strains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4603
# text = IL-4 and IL-13 up-regulated the expression of both genomic and spliced HIV mRNA in monocytes cultured on Teflon, as determined by Northern analysis and p24
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	13	13	NUM	CD	NumType=Card	_	_	_	_
8	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	spliced	spliced	ADJ	JJ	Degree=Pos	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
19	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
30	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	p24	p24	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4604
# text = Ag assay.
1	Ag	ag	ADJ	JJ	Degree=Pos	_	_	_	_
2	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4605
# text = Using a nuclear run-on assay, IL-4 stimulation was shown to enhance transcription by two- to threefold.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	on	on	ADP	IN	_	_	_	_	_
7	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	threefold	threefold	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4606
# text = IL-4 stimulated nuclear factor-kappaB nuclear translocation and binding before enhancement of HIV RNA expression.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	before	before	ADP	IN	_	_	_	_	_
14	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
17	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4607
# text = Conversely, IL-4 and IL-13 markedly and significantly inhibited HIV replication at the transcriptional level in monocyte-derived macrophages, and this occurred whether these cytokines were added before or after HIV infection.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	markedly	markedly	ADV	RB	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	significantly	significantly	ADV	RB	_	_	_	_	_
13	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	whether	whether	SCONJ	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	before	before	ADP	IN	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	after	after	ADP	IN	_	_	_	_	_
37	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
38	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4608
# text = The reversal from stimulation to inhibition occurred after 3 to 5 days of adherence to plastic.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	reversal	reversal	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	5	5	NUM	CD	NumType=Card	_	_	_	_
12	days	day	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4609
# text = IL-4 had no significant effect on HIV reverse transcription.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4610
# text = The effect of both cytokines on the monocyte maturation/differentiation (CD11b, CD13, and CD26) and other macrophage markers (CD14 and CD68) was examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
9	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CD11	CD11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	CD13	CD13	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CD26	CD26	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	CD68	CD68	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4611
# text = IL-4 enhanced CD11b, but inhibited CD26 expression and delayed CD13 loss.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	CD11	CD11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CD26	CD26	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
14	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	13	13	NUM	CD	NumType=Card	_	_	_	_
16	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4612
# text = IL-13 had similar effects on CD11b and CD13, but no effect on CD26.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	13	13	NUM	CD	NumType=Card	_	_	_	_
4	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	b	b	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	CD13	CD13	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	CD26	Cd26	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4613
# text = Hence, these cytokines do not simply enhance monocyte differentiation, but have complex and slightly divergent effects that impact on HIV replication probably through cell signaling pathways and nuclear factor-kappaB translocation.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
5	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	simply	simply	ADV	RB	_	_	_	_	_
8	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	slightly	slightly	ADV	RB	_	_	_	_	_
17	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
18	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	impact	impact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
23	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
24	probably	probably	ADV	RB	_	_	_	_	_
25	through	through	ADP	IN	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
28	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
34	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4614
# text = Document 00300155 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300155	00300155	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4615
# text = Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1. Elf-1 is a lymphoid-specific transcription factor that belongs to the ETS protein family.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ETS	ets	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
11	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n
14	Elf	Elf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	belongs	belong	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4616
# text = It can bind to DNA target sequences within a variety of cytokine genes.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	target	target	NOUN	NN	Number=Sing	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4617
# text = We demonstrate that Elf-1 is constitutively localized in the nucleus which is dependent on the presence of amino acids 86-265.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	amino	amino	DET	DT	_	_	_	_	_
21	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
22	86	86	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	265	265	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4618
# text = Analysis of Gal4-Elf-1 fusion proteins revealed that the N-terminal 86 amino acids of Elf-1 contain a transcriptional activation domain, the activity of which is attenuated by an internal repression domain.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Gal4-	Gal4-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
14	86	86	NUM	CD	NumType=Card	_	_	_	_
15	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
16	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	contain	contain	NOUN	NN	Number=Sing	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
36	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
37	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4619
# text = Furthermore, Elf-1 interacts specifically with the E74 target sequence and can stimulate transcription driven by the E74 site independent of mitogenic signaling.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	E74	E74	PROPN	NNP	Number=Sing	_	_	_	_
11	target	target	NOUN	NN	Number=Sing	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	E74	E74	PROPN	NNP	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4620
# text = Thus, Elf-1 is able to stimulate gene transcription which may be required for the development and activity of lymphocytes.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	development	development	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4621
# text = Document 00300156 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300156	00300156	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4622
# text = Reactive oxygen intermediate-release of fibre-exposed monocytes increases inflammatory cytokine-mRNA level, protein tyrosine kinase and NF-kappaB activity in co-cultured bronchial epithelial cells (BEAS-2B).
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
3	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	release	release	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	fibre	fibre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	co-cultured	co-cultured	ADJ	JJ	Degree=Pos	_	_	_	_
28	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
29	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	BEAS	beas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4623
# text = Some pulmonary diseases like bronchitis or asthma bronchiale are mediated by inflammatory mechanisms in bronchial epithelial cells.
1	Some	some	DET	DT	_	_	_	_	_
2	pulmonary	pulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
3	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
4	like	like	ADP	IN	_	_	_	_	_
5	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
8	bronchiale	bronchiale	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
16	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4624
# text = Alveolar macrophages are located directly in the surrounding of these cells, so that we suppose an interaction between epithelial cells and macrophages regarding to the release of inflammatory mediators.
1	Alveolar	Alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
2	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	directly	directly	ADV	RB	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	surrounding	surrounding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	so	so	SCONJ	IN	_	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	suppose	suppose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
24	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	release	release	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4625
# text = For measuring the contribution of macrophages to the release of inflammatory mediators by bronchial epithelial cells, we established an in vitro model of co-cultured blood monocytes (BM) and BEAS-2B cells in a transwell system (Costar).
1	For	for	SCONJ	IN	_	_	_	_	_
2	measuring	measure	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	release	release	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
15	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	established	establish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
23	model	model	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	co-cultured	co-cultured	ADJ	JJ	Degree=Pos	_	_	_	_
26	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	BM	BM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	BEAS	BEAS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2B	2B	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	transwell	transwell	NOUN	NN	Number=Sing	_	_	_	_
39	system	system	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	Costar	Costar	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4626
# text = BM were exposed to Chrysotile B and soot particle FR 101 in a concentration of 100 microg/10(6) cells.
1	BM	Bm	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	Chrysotile	Chrysotile	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	soot	soot	ADJ	JJ	Degree=Pos	_	_	_	_
9	particle	particle	NOUN	NN	Number=Sing	_	_	_	_
10	FR	Fr	ADP	IN	_	_	_	_	_
11	101	101	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	100	100	NUM	CD	NumType=Card	_	_	_	_
17	microg/10	microg/10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4627
# text = After up to 90 min exposure time ELISA, EMSA (electromobility shift assay) and RT-PCR were used to measure protein tyrosine kinase activity, protein activity of NF-kappaB and cytokine (IL-1beta, IL-6, TNF-alpha) specific mRNA levels in BEAS-2B cells.
1	After	after	ADV	RB	_	_	_	_	_
2	up	up	ADV	RB	_	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	90	90	NUM	CD	NumType=Card	_	_	_	_
5	min	min	ADJ	JJ	Degree=Pos	_	_	_	_
6	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
7	time	time	NOUN	NN	Number=Sing	_	_	_	_
8	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	electromobility	electromobility	NOUN	NN	Number=Sing	_	_	_	_
13	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
14	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	measure	measure	VERB	VB	VerbForm=Inf	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
52	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
53	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	BEAS	BEAS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	2B	2b	PROPN	NNP	Number=Sing	_	_	_	_
58	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4628
# text = We observed an increase in protein tyrosine kinase activity (up to 1.8 +/- 0.5-fold) and NF-kappaB protein activity in BEAS-2B cells after particle or fibre exposure of co-cultured BM.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	up	up	ADP	IN	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	1.8	1.8	NUM	CD	NumType=Card	_	_	_	_
14	+/-	+/-	SYM	SYM	_	_	_	_	_
15	0.5	0.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	BEAS	BEAS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	particle	particle	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	fibre	fibre	NOUN	NN	Number=Sing	_	_	_	_
35	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	co-cultured	co-cultured	ADJ	JJ	Degree=Pos	_	_	_	_
38	BM	BM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4629
# text = Consecutive IL-1beta-, IL-6- and TNF-alpha-mRNA were elevated (up to 1.9 +/- 0.58-fold).
1	Consecutive	Consecutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	up	up	ADP	IN	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	1.9	1.9	NUM	CD	NumType=Card	_	_	_	_
23	+/-	+/-	SYM	SYM	_	_	_	_	_
24	0.58	0.58	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4630
# text = Protein tyrosine kinase activity, NF-kappaB activity, and the synthesis of cytokine-specific mRNA were inhibited by antioxidants.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4631
# text = These data suggest a ROI-dependent NF-kappaB mediated transcription of inflammatory cytokines in bronchial epithelial cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	ROI	Roi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
18	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4632
# text = Document 00300158 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300158	00300158	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4633
# text = Characterization of the human myeloid cell nuclear differentiation antigen gene promoter.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4634
# text = MNDA (myeloid cell nuclear differentiation antigen) is an interferon alpha regulated nuclear protein expressed only in cells of the human myelomonocytic lineage.
1	MNDA	MNDA	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	only	only	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4635
# text = To identify mechanisms responsible for this lineage-specific and interferon-regulated expression, the 5' flanking sequence of the gene has been characterized.
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	interferon	interferon	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	'	'	PUNCT	``	_	_	_	_	_
19	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
20	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4636
# text = Two interferon-stimulated response elements (ISRE) flank a multiple transcription start site region identifying MNDA as a TATA-less interferon-regulated gene.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	ISRE	ISRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	flank	flank	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	start	start	NOUN	NN	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	identifying	identify	VERB	VBG	VerbForm=Ger	_	_	_	_
18	MNDA	MNDa	PROPN	NNP	Number=Sing	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
24	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4637
# text = Other DNA elements present include a cluster of Myb sites, several Ets, an Ets related PU.1 site and an Sp1 site located within 600 bp of the transcription start sites.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	600	600	NUM	CD	NumType=Card	_	_	_	_
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	start	start	NOUN	NN	Number=Sing	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4638
# text = In addition, DNA methylation was revealed as one of the possible factors in establishing MNDA expression.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	one	one	NUM	CD	NumType=Card	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	establishing	establish	VERB	VBG	VerbForm=Ger	_	_	_	_
16	MNDA	MNDA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4639
# text = The 5' flanking sequence has promoter activity which is elevated by interferon alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	PUNCT	``	_	_	_	_	_
4	flanking	flanking	NOUN	NN	Number=Sing	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4640
# text = The findings indicate that MNDA expression is regulated by mechanisms similar to other myelomonocytic cell specific genes and genes up-regulated by interferon alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	MNDA	MNDA	PROPN	NNP	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4641
# text = Document 00300160 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300160	00300160	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4642
# text = Mycobacterium tuberculosis mannose-capped lipoarabinomannan can induce NF-kappaB-dependent activation of human immunodeficiency virus type 1 long terminal repeat in T cells.
1	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
2	tuberculosis	tuberculosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	mannose	mannose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	capped	cap	ADJ	JJ	Degree=Pos	_	_	_	_
6	lipoarabinomannan	lipoarabinomannan	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
22	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
23	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4643
# text = Tuberculosis has emerged as an epidemic, extended by the large number of individuals infected with human immunodeficiency virus type 1 (HIV-1).
1	Tuberculosis	Tuberculosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	emerged	emerge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	epidemic	epidemic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	extended	extend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
12	number	number	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4644
# text = The major goal of this study was to determine whether the mycobacterial cell wall component mannose-capped lipoarabinomannan (ManLAM) of Mycobacterium tuberculosis (M.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	goal	goal	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
10	whether	whether	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	mannose	mannose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	capped	cap	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	lipoarabinomannan	lipoarabinomannan	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
25	tuberculosis	tuberculosis	PROPN	NNPS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4645
# text = tuberculosis) could activate transcription of HIV-1 in T cells with the use of an in vitro cell culture system.
1	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
4	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	use	use	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4646
# text = These experiments are of prime importance considering that CD4-expressing T lymphocytes represent the major virus reservoir in the peripheral blood of infected individuals.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	prime	prime	ADJ	JJ	Degree=Pos	_	_	_	_
6	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
7	considering	consider	VERB	VBG	VerbForm=Ger	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-expressing	-expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
21	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4647
# text = Using the 1G5 cell line harbouring the luciferase reporter gene under the control of the HIV-1 LTR, it was first found that culture protein filtrates (CFP) from M. tuberculosis or purified ManLAM could activate HIV-1 LTR-dependent gene expression unlike similarly prepared CFP extracts devoid of ManLAM.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	1G5	1G5	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	line	line	NOUN	NN	Number=Sing	_	_	_	_
6	harbouring	harbour	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	under	under	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	first	first	ADV	RB	_	_	_	_	_
24	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	culture	culture	ADJ	JJ	Degree=Pos	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	filtrates	filtrate	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	CFP	CFP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
34	tuberculosis	tuberculosis	PROPN	NNPS	Number=Plur	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
37	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	_
38	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
39	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
40	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	X	LS	_	_	_	_	_
43	LTR-	LTR-	X	AFX	_	_	_	_	SpaceAfter=No
44	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	unlike	unlike	ADP	IN	_	_	_	_	_
48	similarly	similarly	ADV	RB	_	_	_	_	_
49	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	CFP	Cfp	NOUN	NN	Number=Sing	_	_	_	_
51	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
52	devoid	devoid	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4648
# text = The implication of protein tyrosine kinase(s), protein kinase A and/or protein kinase C was highlighted by the abrogation of the ManLAM-mediated activation of HIV-1 LTR-driven gene expression using herbimycin A and H7.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	implication	implication	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	A	a	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	or	or	CCONJ	CC	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	C	c	PROPN	NNP	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	highlighted	highlight	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	abrogation	abrogation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
40	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
41	A	a	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	H7	H7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4649
# text = It was also determined, using electrophoresis mobility shift assays, that M. tuberculosis ManLAM led to the nuclear translocation of the transcription factor NF-kappaB.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	electrophoresis	electrophoresis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
9	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
10	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
14	tuberculosis	tuberculosis	PROPN	NNP	Number=Sing	_	_	_	_
15	ManLAM	ManLAm	PROPN	NNP	Number=Sing	_	_	_	_
16	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4650
# text = M. tuberculosis ManLAM resulted in clear induction of the luciferase gene placed under the control of the wild-type, but not the kappaB-mutated, HIV-1 LTR region.
1	M.	m.	PROPN	NNP	Number=Sing	_	_	_	_
2	tuberculosis	tuberculosis	PROPN	NNP	Number=Sing	_	_	_	_
3	ManLAM	ManLAm	PROPN	NNP	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	placed	place	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	under	under	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	ADV	RB	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	kappaB-	kappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
32	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4651
# text = Finally, the ManLAM-mediated activation of HIV-1 LTR transcription was found to be independent of the autocrine or paracrine action of endogenous TNF-alpha.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ManLAM	ManLAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	paracrine	paracrine	NOUN	NN	Number=Sing	_	_	_	_
24	action	action	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
27	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4652
# text = The results suggest that M. tuberculosis can upregulate HIV-1 expression in T cells and could thus have the potential to influence the pathogenesis of HIV-1 infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
6	tuberculosis	tuberculosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	upregulate	upregulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	thus	thus	ADV	RB	_	_	_	_	_
19	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4653
# text = Document 00300166 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300166	00300166	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4654
# text = [Corticoids and allergy]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Corticoids	Corticoid	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	allergy	allergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4655
# text = Inflammation is constantly observed in allergic reactions.
1	Inflammation	Inflammation	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	constantly	constantly	ADV	RB	_	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
7	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4656
# text = Corticosteroids are most effective in preventing the late phase of allergic reaction.
1	Corticosteroids	Corticosteroid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	most	most	ADV	RBS	_	_	_	_	_
4	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
9	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
12	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4657
# text = The action of glucocorticosteroids is mediated through glucocorticoid receptors present in the cellular cytoplasm.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	action	action	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticosteroids	glucocorticosteroid	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	glucocorticoid	glucocorticoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4658
# text = When activated, glucocorticoid receptors form a dimer and bind to DNA after migration into the nucleus.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	glucocorticoid	glucocorticoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	form	from	ADP	IN	Typo=Yes	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4659
# text = Interaction to DNA induces changes in the transcription rate, leading to either gene induction or gene repression.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	either	either	DET	DT	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4660
# text = Glucocorticoid receptors are also able to interact with transcriptional factors such as AP-1 (activator protein-1) of NF-kappa B (nuclear factor-kappa B).
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4661
# text = Through these actions glucocorticosteroids are susceptible to modify functions of cells involved in the allergic inflammatory response.
1	Through	through	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
4	glucocorticosteroids	glucocorticosteroid	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	modify	modify	VERB	VB	VerbForm=Inf	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4662
# text = They are in particular able to inhibit most of the pro-inflammatory functions of the eosinophils.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
8	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4663
# text = Document 00300167 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300167	00300167	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4664
# text = Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells.
1	Alpha	Alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
4	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4665
# text = Acquired immunodeficiency syndrome (AIDS) results from infection with a human immunodeficiency virus (HIV).
1	Acquired	acquire	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4666
# text = The long terminal repeat (LTR) region of HIV proviral DNA contains binding sites for nuclear factor kappa B (NF-kappa B), and this transcriptional activator appears to regulate HIV activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
3	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
4	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
11	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
32	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
35	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4667
# text = Recent findings suggest an involvement of reactive oxygen species (ROS) in signal transduction pathways leading to NF-kappa B activation.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
8	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
9	species	species	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	ROS	Ros	X	ADD	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
15	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4668
# text = The present study was based on reports that antioxidants which eliminate ROS should block the activation of NF-kappa B and subsequently HIV transcription, and thus antioxidants can be used as therapeutic agents for AIDS.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	based	base	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	antioxidants	antioxidant	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	which	which	PRON	WDT	PronType=Int	_	_	_	_
11	eliminate	eliminate	ADJ	JJ	Degree=Pos	_	_	_	_
12	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	_
13	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
14	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	subsequently	subsequently	ADV	RB	_	_	_	_	_
24	HIV	Hiv	VERB	VBP	Abbr=Yes|Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	thus	thus	ADV	RB	_	_	_	_	_
29	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
30	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
31	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
32	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
35	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4669
# text = Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml).
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	x	x	SYM	SYM	_	_	_	_	_
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
20	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	_
21	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
26	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
38	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	NOUN	NN	Number=Sing	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
46	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	25	25	NUM	CD	NumType=Card	_	_	_	_
52	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
54	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	_
56	or	or	CCONJ	CC	_	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
59	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
62	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	50	50	NUM	CD	NumType=Card	_	_	_	_
67	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4670
# text = The inhibitory action of alpha-lipoic acid was found to be very potent as only 4 mM was needed for a complete inhibition, whereas 20 mM was required for N-acetylcysteine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	action	action	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
8	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	very	very	ADV	RB	_	_	_	_	_
14	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	mM	mm	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
24	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	wherea	SCONJ	IN	_	_	_	_	_
27	20	20	NUM	CD	NumType=Card	_	_	_	_
28	mM	mm	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	N-	n-	X	GW	_	_	_	_	SpaceAfter=No
33	acetylcysteine	acetylcysteine	PRON	PRP	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4671
# text = These results indicate that alpha-lipoic acid may be effective in AIDS therapeutics.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
8	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
14	therapeutics	therapeutic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4672
# text = Document 00300168 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300168	00300168	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4673
# text = Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4674
# text = Glucocorticoids have an inhibitory effect on inflammatory and immune responses, and this may be through the modulation of transcription factor binding to DNA.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4675
# text = The interaction of the transcription factors, activator protein-1 (AP-1), nuclear factor kappa B (NF kappa B), and cAMP-responsive element binding protein (CREB) with DNA and glucocorticoid receptors (GR) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
32	element	element	NOUN	NN	Number=Sing	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
42	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
50	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
51	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
52	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	by	by	ADP	IN	_	_	_	_	_
55	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
56	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
57	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
58	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4676
# text = TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
12	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	_
25	DNA	Dna	PROPN	NNP	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	up	up	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	200	200	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	38	38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	over	over	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	min	min	NOUN	NN	Number=Sing	_	_	_	_
45	time	time	NOUN	NN	Number=Sing	_	_	_	_
46	course	course	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4677
# text = Dexamethasone produced a rapid and sustained increase in glucocorticoid response element binding and a concomitant 40-50% decrease in AP-1, NF kappa B, and CREB DNA binding that was blocked by combined dexamethasone and cytokine or PMA treatment.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	sustained	sustain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	concomitant	concomitant	NOUN	NN	Number=Sing	_	_	_	_
16	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	%	%	SYM	NN	Number=Sing	_	_	_	_
20	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	_
32	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4678
# text = These latter effects were due to increases in the nuclear localization of GR, not to reduced amounts of the other transcription factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	due	due	ADP	IN	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	reduced	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
18	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4679
# text = This suggests that in these cells GR within the nucleus interacts with cytokine-stimulated transcription factors by the process of cross coupling.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	GR	Gr	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nucleus	nucleus	ADJ	JJ	Degree=Pos	_	_	_	_
11	interacts	interacts	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	process	process	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cross	cross	NOUN	NN	Number=Sing	_	_	_	_
23	coupling	coupling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4680
# text = This may be an important molecular site of steroid action.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4681
# text = Document 00300178 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300178	00300178	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4682
# text = Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB [see comments]
1	Helenalin	Helenalin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	sesquiterpene	sesquiterpene	NOUN	NN	Number=Sing	_	_	_	_
6	lactone	lactone	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	Arnica	Arnica	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	see	see	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4683
# text = Alcoholic extracts prepared form Arnicae flos, the collective name for flowerheads from Arnica montana and A.
1	Alcoholic	Alcoholic	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	form	from	NOUN	NN	Number=Sing	_	_	_	_
5	Arnicae	Arnicae	NOUN	NN	Number=Sing	_	_	_	_
6	flos	flo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	collective	collective	ADJ	JJ	Degree=Pos	_	_	_	_
10	name	name	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	flowerheads	flowerhead	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	Arnica	Arnica	PROPN	NNP	Number=Sing	_	_	_	_
15	montana	montana	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4684
# text = chamissonis ssp. foliosa, are used therapeutically as anti-inflammatory remedies.
1	chamissonis	chamissonis	NOUN	NN	Number=Sing	_	_	_	_
2	ssp.	ssp.	NOUN	NN	Number=Sing	_	_	_	_
3	foliosa	foliosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	therapeutically	therapeutically	ADV	RB	_	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	remedies	remedy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4685
# text = The active ingredients mediating the pharmacological effect are mainly sesquiterpene lactones, such as helenalin, 11alpha,13-dihydrohelenalin, chamissonolid and their ester derivatives.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	ingredients	ingredient	NOUN	NNS	Number=Plur	_	_	_	_
4	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	mainly	mainly	ADV	RB	_	_	_	_	_
10	sesquiterpene	sesquiterpene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	lactones	lactone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	helenalin	helenalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	11alpha,13	11alpha,13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dihydrohelenalin	dihydrohelenalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	chamissonolid	chamissonolid	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
25	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4686
# text = While these compounds affect various cellular processes, current data do not fully explain how sesquiterpene lactones exert their anti-inflammatory effect.
1	While	while	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
4	affect	affect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
6	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_
7	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
10	data	data	NOUN	NN	Number=Sing	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	fully	fully	ADV	RB	_	_	_	_	_
14	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
15	how	how	ADV	WRB	PronType=Int	_	_	_	_
16	sesquiterpene	sesquiterpene	NOUN	NN	Number=Sing	_	_	_	_
17	lactones	lactone	NOUN	NNS	Number=Plur	_	_	_	_
18	exert	exert	ADP	IN	Typo=Yes	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4687
# text = We show here that helenalin, and, to a much lesser degree, 11alpha,13-dihydrohelenalin and chamissonolid, inhibit activation of transcription factor NF-kappaB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	helenalin	helenalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
12	lesser	lesser	NOUN	NN	Number=Sing	_	_	_	_
13	degree	degree	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	11alpha,13	11alpha,13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-dihydrohelenalin	-dihydrohelenalin	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	chamissonolid	chamissonolid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4688
# text = This difference in efficacy, which correlates with the compounds' anti-inflammatory potency in vivo, may be explained by differences in structure and conformation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	'	's	PART	POS	_	_	_	_	_
12	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	conformation	conformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4689
# text = NF-kappaB, which resides in an inactive, cytoplasmic complex in unstimulated cells, is activated by phosphorylation and degradation of its inhibitory subunit, IkappaB.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	resides	reside	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
26	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4690
# text = Helenalin inhibits NF-kappaB activation in response to four different stimuli in T-cells, B-cells and epithelial cells and abrogates kappaB-driven gene expression.
1	Helenalin	Helenalin	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	four	four	NUM	CD	NumType=Card	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
12	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4691
# text = This inhibition is selective, as the activity of four other transcription factors, Oct-1, TBP, Sp1 and STAT 5 was not affected.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	as	as	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	four	four	NUM	CD	NumType=Card	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	TBP	TBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4692
# text = We show that inhibition is not due to a direct modification of the active NF-kappaB heterodimer.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	due	due	ADP	IN	_	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
11	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4693
# text = Rather, helenalin modifies the NF-kappaB/IkappaB complex, preventing the release of IkappaB.
1	Rather	Rather	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	helenalin	helenalin	ADP	IN	_	_	_	_	_
4	modifies	modify	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	release	release	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4694
# text = These data suggest a molecular mechanism for the anti-inflammatory effect of sesquiterpene lactones, which differs from that of other nonsteroidal anti-inflammatory drugs (NSAIDs), indomethacin and acetyl salicylic acid.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	sesquiterpene	sesquiterpene	NOUN	NN	Number=Sing	_	_	_	_
13	lactones	lactone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	differs	differ	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	nonsteroidal	nonsteroidal	ADJ	JJ	Degree=Pos	_	_	_	_
22	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NSAIDs	NSAid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indomethacin	indomethacin	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	_
31	salicylic	salicylic	ADJ	JJ	Degree=Pos	_	_	_	_
32	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4695
# text = Document 00300181 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300181	00300181	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4696
# text = Competent transcription initiation by RNA polymerase II in cell-free extracts from xeroderma pigmentosum groups B and D in an optimized RNA transcription assay.
1	Competent	Competent	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
6	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	xeroderma	xeroderma	NOUN	NN	Number=Sing	_	_	_	_
15	pigmentosum	pigmentosum	NOUN	NN	Number=Sing	_	_	_	_
16	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	D	d	PROPN	NNP	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	optimized	optimized	ADJ	JJ	Degree=Pos	_	_	_	_
23	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4697
# text = The human autosomal recessive disease, xeroderma pigmentosum (XP), can result from mutations in any one of seven genes, designated XPA through XPG.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	autosomal	autosomal	ADJ	JJ	Degree=Pos	_	_	_	_
4	recessive	recessive	ADJ	JJ	Degree=Pos	_	_	_	_
5	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	xeroderma	xeroderma	NOUN	NN	Number=Sing	_	_	_	_
8	pigmentosum	pigmentosum	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	any	any	DET	DT	_	_	_	_	_
19	one	one	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	seven	seven	NUM	CD	NumType=Card	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	XPA	XPA	PROPN	NNP	Number=Sing	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	XPG	XPG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4698
# text = Of these, the XPB and XPD genes encode proteins that are subunits of a general transcription factor, TFIIH, involved in both nucleotide excision repair (NER) and initiation of mRNA transcription by RNA polymerase II.
1	Of	of	ADP	IN	_	_	_	_	_
2	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	XPB	XPB	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	XPD	XPD	PROPN	NNP	Number=Sing	_	_	_	_
8	genes	gene	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	TFIIH	TFIIh	INTJ	UH	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
26	excision	excision	NOUN	NN	Number=Sing	_	_	_	_
27	repair	repair	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NER	NER	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
38	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
39	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4699
# text = In humans, mutation of the XPB or XPD gene impairs NER, resulting in hyper-sensitivity to sunlight and greatly increased skin tumor formation.
1	In	in	ADP	IN	_	_	_	_	_
2	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	XPB	XPB	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	XPD	XPD	AUX	MD	VerbForm=Fin	_	_	_	_
10	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
11	impairs	impairs	ADV	RB	_	_	_	_	_
12	NER	ner	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	hyper	hyper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	sunlight	sunlight	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	greatly	greatly	ADV	RB	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4700
# text = However, no transcription deficiency has been demonstrated in either XP-B or XP-D.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	either	either	DET	DT	_	_	_	_	_
11	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	B	B	PROPN	NNP	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4701
# text = We have employed an optimized cell-free RNA transcription assay to analyze transcription activity of XP-B and XP-D.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	employed	employ	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	optimized	optimized	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
9	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4702
# text = Although the growth rate was normal, the XP-B and XP-D cells contained reduced amounts of TFIIH.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	XP	Xp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	XP	Xp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	D	d	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	TFIIH	TFIIH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4703
# text = Extracts prepared from XP-B and XP-D lymphoblastoid cells exhibited similar transcription activity from the adenovirus major late promoter when compared to that in extracts from normal cells.
1	Extracts	Extract	NOUN	NNS	Number=Plur	_	_	_	_
2	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	XP	Xp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	D	d	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	when	when	ADV	WRB	PronType=Int	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4704
# text = Thus, we conclude that the XP-B and XP-D lymphoblastoid cells do not have impaired RNA transcription activity.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	XP	Xp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	XP	Xp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	D	d	NOUN	NN	Number=Sing	_	_	_	_
14	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	have	have	AUX	VB	VerbForm=Inf	_	_	_	_
19	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4705
# text = We consider the possible consequences of the reduced cellular content of TFIIH for the clinical symptoms in XP-B or XP-D patients, and discuss a 'conditional phenotype' that may involve an impairment of cellular function only under certain growth conditions.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	consider	consider	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
5	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	content	content	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TFIIH	TFIIh	PROPN	NNP	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
16	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	XP	XP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	XP	Xp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	D	d	PROPN	NNP	Number=Sing	_	_	_	_
25	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	discuss	discuss	VERB	VB	VerbForm=Inf	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
31	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
32	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	'	'	PUNCT	''	_	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	impairment	impairment	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
41	function	function	NOUN	NN	Number=Sing	_	_	_	_
42	only	only	ADV	RB	_	_	_	_	_
43	under	under	ADP	IN	_	_	_	_	_
44	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
45	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
46	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4706
# text = Document 00300187 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300187	00300187	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4707
# text = Targeted remodeling of human beta-globin promoter chromatin structure produces increased expression and decreased silencing.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
10	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
11	produces	produce	NOUN	NNS	Number=Plur	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	silencing	silencing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4708
# text = The chromatin structure of the human beta-globin gene locus assumes a transcriptionally-active conformation in erythroid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
3	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
12	assumes	assume	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	conformation	conformation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4709
# text = One feature of this chromatin reorganization is the formation of DNase 1 hypersensitive sites in the regions of active globin gene promoters.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
6	reorganization	reorganization	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
20	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4710
# text = This reorganization requires the globin locus control region and is associated with normal expression of the beta-like globin genes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	reorganization	reorganization	NOUN	NN	Number=Sing	_	_	_	_
3	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
6	locus	locus	CCONJ	CC	_	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	like	like	SCONJ	IN	_	_	_	_	_
20	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4711
# text = To determine whether it is possible to artificially enhance the opening of the chromatin structure of a minimal beta-globin promoter, we placed a 101bp, erythroid-specific DNase 1 hypersensitive site-forming element (HSFE) immediately upstream of the beta-globin promoter and gene.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	artificially	artificially	ADV	RB	_	_	_	_	_
9	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	opening	opening	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
15	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	placed	place	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	101	101	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
39	element	element	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	HSFE	HSFE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	immediately	immediately	ADV	RB	_	_	_	_	_
44	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
50	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4712
# text = This element includes binding sites for NF-E2, AP-1, GATA-1 and Sp-1.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Sp	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4713
# text = Constructs were stably transfected into murine erythroleukemia cells and promoter chromatin structure and gene expression were analyzed.
1	Constructs	Construct	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	murine	murine	PRON	PRP	_	_	_	_	_
7	erythroleukemia	erythroleukemia	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
11	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
12	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4714
# text = The HSFE induced an area of enhanced DNase 1 hypersensitivity extending from the transcriptional start site to -300bp of the artificial promoter and significantly increased the proportion of beta-globin promoters in an open chromatin configuration.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HSFE	HSFE	PROPN	NNP	Number=Sing	_	_	_	_
3	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	area	area	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	hypersensitivity	hypersensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	start	start	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	300	300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	artificial	artificial	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	significantly	significantly	ADV	RB	_	_	_	_	_
27	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
34	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
38	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
39	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4715
# text = This remodeling of promoter chromatin structure resulted in 3-fold increases in beta-globin gene transcription and induction, and inhibited long-term beta-globin gene silencing.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
6	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
7	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
12	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	term	term	NOUN	NN	Number=Sing	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	silencing	silencing	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4716
# text = These results indicate that a relatively small cis-acting element is able to enhance remodeling of promoter chromatin structure resulting in increased beta-globin gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	relatively	relatively	ADV	RB	_	_	_	_	_
7	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
8	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-acting	-acting	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
15	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
19	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
20	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4717
# text = Document 00300191 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300191	00300191	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4718
# text = Transcriptional control of steroid-regulated apoptosis in murine thymoma cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
10	thymoma	thymoma	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4719
# text = Early studies in murine T cell lines indicated that transcriptional transactivation functions encoded in the glucocorticoid receptor (GR)
1	Early	Early	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
12	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
13	encoded	encod	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 4720
# text = N-terminal domain are required for glucocorticoid-mediated apoptosis.
1	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	glucocorticoid	glucocorticoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4721
# text = However, more recent studies in human T cell lines have suggested that the N-terminal domain is not necessary for steroid-regulated apoptosis and that GR-mediated transrepression may be the more critical mechanism.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	more	more	ADV	RBR	_	_	_	_	_
4	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	transrepression	transrepression	NOUN	NN	Number=Sing	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	more	more	ADV	RBR	_	_	_	_	_
36	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
37	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4722
# text = To better understand the contribution of the GR N-terminal transactivation domain in mediating murine thymocyte apoptosis, we stably transfected GR, GR variants, and the androgen receptor (AR) into receptor-negative S49 murine thymoma cells.
1	To	to	ADV	RB	_	_	_	_	_
2	better	better	ADV	RBR	Degree=Cmp	_	_	_	_
3	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
9	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	murine	murine	PRON	PRP	_	_	_	_	_
16	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
17	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	stably	stably	ADV	RB	_	_	_	_	_
21	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
25	variants	variant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	AR	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	into	into	ADP	IN	_	_	_	_	_
35	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
38	S49	s49	NOUN	NN	Number=Sing	_	_	_	_
39	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
40	thymoma	thymoma	ADP	IN	_	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4723
# text = GR expression levels were shown to be rate-limiting for initiating the apoptotic pathway, and a positive correlation between steroid sensitivity and GR-mediated induction of an integrated mouse mammary tumor virus (MMTV) LTR reporter gene was observed.
1	GR	Gr	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	limiting	limit	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	SCONJ	IN	_	_	_	_	_
12	initiating	initiat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
20	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	GR	Gr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
33	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
34	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
35	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	LTR	Ltr	ADJ	JJ	Degree=Pos	_	_	_	_
40	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4724
# text = Analysis of GR chimeric receptors containing the potent VP16 and E1A viral transactivation domains in place of the GR N terminus revealed that even low level expression of these receptors resulted in both enhanced steroid sensitivity and MMTV induction, thus supporting a role for transactivation in apoptosis.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	GR	Gr	ADJ	JJ	Degree=Pos	_	_	_	_
4	chimeric	chimeric	NOUN	NN	Number=Sing	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
9	VP16	VP16	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	place	place	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
21	N	N	PROPN	NNP	Number=Sing	_	_	_	_
22	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
23	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	even	even	ADV	RB	_	_	_	_	_
26	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
27	level	level	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
32	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	both	both	CCONJ	CC	_	_	_	_	_
35	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
37	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	MMTV	Mmtv	NOUN	NN	Number=Sing	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	thus	thus	ADV	RB	_	_	_	_	_
43	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	role	role	NOUN	NN	Number=Sing	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4725
# text = In contrast, we found that AR can initiate apoptosis in S49 cells after treatment with 5 alpha-dihydrotestosterone, despite its relative inability to induce high level expression of MMTV.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	AR	ar	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	S49	S49	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dihydrotestosterone	dihydrotestosterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	despite	despite	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
25	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4726
# text = To investigate this further, we examined the steroid-regulated expression of an endogenous thymocyte-specific gene called GIG18.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	GIG18	GIG18	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4727
# text = We found that GIG18 was rapidly induced to comparable levels by both AR and GR, demonstrating that AR can indeed function as a transcriptional activator in S49 cells and, moreover, that GIG18 induction may be a marker of early apoptotic events in steroid-treated cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	GIG18	GIG18	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	rapidly	rapidly	ADV	RB	_	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	AR	be	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	AR	be	PROPN	NNP	Number=Sing	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	indeed	indeed	ADV	RB	_	_	_	_	_
22	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	S49	S49	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	GIG18	Gig18	NOUN	NN	Number=Sing	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
37	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
38	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
43	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
44	events	event	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4728
# text = Taken together, these results support our conclusion that transcriptional transactivation is a necessary signaling component of S49 cell apoptosis, although an additional role for GR-mediated transrepression cannot be excluded.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
8	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	component	component	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	S49	S49	NUM	CD	NumType=Card	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	although	although	SCONJ	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	mediated	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
30	transrepression	transrepression	NOUN	NN	Number=Sing	_	_	_	_
31	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
32	not	not	PART	RB	_	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	excluded	exclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4729
# text = Document 00300192 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300192	00300192	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4730
# text = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.
1	RFLAT	Rflat	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
7	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
8	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	RANTES	Rante	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4731
# text = RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a chemoattractant cytokine (chemokine) important in the generation of inflammatory infiltrate and human immunodeficiency virus entry into immune cells.
1	RANTES	RANTES	INTJ	UH	_	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	upon	upon	ADP	IN	_	_	_	_	_
5	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Normal	normal	PROPN	NNP	Number=Sing	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
10	Expressed	express	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Secreted	Secret	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	infiltrate	infiltrate	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
31	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
32	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
33	into	into	ADP	IN	_	_	_	_	_
34	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4732
# text = RANTES is expressed late (3-5 days) after activation in T lymphocytes.
1	RANTES	RANTES	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4733
# text = Using expression cloning, we identified the first "late" T lymphocyte associated transcription factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1).
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
10	late	late	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	"	"	PUNCT	''	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	named	nam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
21	RANTES	rantes	PROPN	NNP	Number=Sing	_	_	_	_
22	Factor	factor	PROPN	NNP	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Late	Late	PROPN	NNP	Number=Sing	_	_	_	_
25	Activated	activate	PROPN	NNP	Number=Sing	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	Lymphocytes	Lymphocyte	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	"	"	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	RFLAT	RFLAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4734
# text = RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is expressed in T cells 3 days after activation, coincident with RANTES expression.
1	RFLAT	Rflat	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
11	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	days	day	NOUN	NNS	Number=Plur	_	_	_	_
22	after	after	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	coincident	coincident	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	RANTES	rantes	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4735
# text = While Rel proteins play the dominant role in RANTES gene expression in fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.
1	While	while	SCONJ	IN	_	_	_	_	_
2	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	RANTES	RANTES	PROPN	NNP	Number=Sing	_	_	_	_
10	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	RFLAT	RFLAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
21	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	RANTES	Rante	PROPN	NNP	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4736
# text = Document 00300194 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300194	00300194	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4737
# text = Infection and replication of Tat- human immunodeficiency viruses: genetic analyses of LTR and tat mutations in primary and long-term human lymphoid cells.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
9	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
12	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
17	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	term	term	NOUN	NN	Number=Sing	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4738
# text = Tat is an essential regulatory protein for the replication of human immunodeficiency virus (HIV).
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4739
# text = Mutations in the tat gene have been shown to block HIV replication in human T cells.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4740
# text = Several studies have established that Tat releases an elongation block to the transcription of HIV long terminal repeat (LTR); however, it is not known whether this mechanism alone is sufficient to explain the block to HIV replication in human T cells when Tat is absent.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
7	releases	release	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	_
10	block	block	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
17	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
18	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	whether	whether	SCONJ	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
32	alone	alone	ADV	RB	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	block	block	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
41	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	when	when	ADV	WRB	PronType=Int	_	_	_	_
47	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4741
# text = It is possible that Tat is also needed for other functions during HIV replication.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4742
# text = To test these hypotheses, we studied several tat mutants, including two stop codon mutants and one deletion mutant using replication-competent HIV-1 constructs carrying wild-type or mutant LTRs with modifications in the NF-kappa B and/or Sp1 binding sites.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	hypotheses	hypothese	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
10	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	stop	stop	NOUN	NN	Number=Sing	_	_	_	_
15	codon	codon	NOUN	NN	Number=Sing	_	_	_	_
16	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	one	one	NUM	CD	NumType=Card	_	_	_	_
19	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
20	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	competent	competent	NOUN	NN	Number=Sing	_	_	_	_
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
29	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
30	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
35	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
45	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
46	or	or	CCONJ	CC	_	_	_	_	_
47	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
48	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
49	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4743
# text = In this study, we show that Tat- HIV-1 with wild-type LTRs can replicate in HeLa cells, and the virus produced from HeLa cells can infect primary peripheral blood lymphocytes and macrophages.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
32	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
33	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
34	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
35	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
36	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4744
# text = It was found that the propagation of the Tat mutants containing wild-type LTRs was less efficient than that of the LTR-modified Tat mutants.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	propagation	propagation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
10	mutants	mutant	PROPN	NNPS	Number=Plur	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	LTRs	LTR	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
18	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR-	ltr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
26	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4745
# text = Large amounts of viral RNA and particles were synthesized in infections established using the tat mutants that contain modified LTRs.
1	Large	large	ADJ	JJ	Degree=Pos	_	_	_	_
2	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	particles	particle	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
12	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
16	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4746
# text = However, this efficient propagation of the LTR-modified tat mutants was restricted to some lymphoid cell lines that have been transformed with other viruses.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
5	propagation	propagation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
11	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	some	some	DET	DT	_	_	_	_	_
16	lymphoid	lymphoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	viruses	virus	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4747
# text = Thus, despite its essential role for releasing an elongation block, Tat is not otherwise absolutely required for synthesis of full-length HIV transcripts and assembly of virus particles.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	despite	despite	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	releasing	release	VERB	VBG	VerbForm=Ger	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	_
11	block	block	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	otherwise	otherwise	ADV	RB	_	_	_	_	_
17	absolutely	absolutely	ADV	RB	_	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	length	length	NOUN	NN	Number=Sing	_	_	_	_
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
26	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	particles	particle	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4748
# text = Direct sequencing of the viral genomes and reinfection kinetics showed no evidence of wild-type reversion even after prolonged infection with the Tat- virus.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
6	genomes	genome	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	reinfection	reinfection	NOUN	NN	Number=Sing	_	_	_	_
9	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	reversion	reversion	NOUN	NN	Number=Sing	_	_	_	_
18	even	even	ADV	RB	_	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4749
# text = The implications for in vivo HIV-1 replication and potential application of this system to the study of alternative Tat function are discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
12	application	application	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	system	system	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	study	study	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
21	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
22	function	function	NOUN	NN	Number=Sing	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4750
# text = Document 00300195 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300195	00300195	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4751
# text = The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	prointerleukin	prointerleukin	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	start	start	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4752
# text = In these studies, we have identified DNA sequences and specific protein interactions necessary for transcriptional regulation of the human prointerleukin 1 beta (proIL-1 beta) gene.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	prointerleukin	prointerleukin	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4753
# text = A cell-type-independent lipopolysaccharide (LPS)-responsive enhancer element located between -3757 and -2729 bp upstream from the transcription start site (cap site) consisted of at least six discrete subregions which were essential to the maximal induction by LPS in transfected monocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	-3757	-3757	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	2729	2729	NUM	CD	NumType=Card	_	_	_	_
21	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
22	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	start	start	NOUN	NN	Number=Sing	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	at	at	ADV	RB	_	_	_	_	_
35	least	least	ADV	RBS	Degree=Sup	_	_	_	_
36	six	six	NUM	CD	NumType=Card	_	_	_	_
37	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
38	subregions	subregion	NOUN	NNS	Number=Plur	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4754
# text = The enhancer also appeared to mediate phorbol myristate acetate induction in monocytes and IL-1 responsiveness in fibroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4755
# text = Deletion and base substitution mutations along with DNA binding studies demonstrated that the enhancer contained a minimum of three functional protein binding sequences, two of which appeared to be important for gene induction.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	base	base	NOUN	NN	Number=Sing	_	_	_	_
4	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
5	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
6	along	along	ADP	IN	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
11	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	minimum	minimum	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	three	three	NUM	CD	NumType=Card	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4756
# text = One of the essential proteins which bound to the enhancer was similar or identical to members of the C/EBP family of transcription factors required for both IL-1- and LPS-specific induction of the IL-6 gene (i.e., the NF-IL6 proteins).
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	members	member	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	6	6	NUM	CD	NumType=Card	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
50	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4757
# text = When ligated to the proIL-1 beta cap site-proximal region (located between -131 to +12), both the proIL-1 beta and the simian virus 40 enhancer elements functioned more efficiently in monocytes than in HeLa cells, which are not normally competent for IL-1 beta expression.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	ligated	ligate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	131	131	NUM	CD	NumType=Card	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	+12	+12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
32	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
33	40	40	NUM	CD	NumType=Card	_	_	_	_
34	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
35	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
36	functioned	function	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	more	more	ADV	RBR	_	_	_	_	_
38	efficiently	efficiently	ADV	RB	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
41	than	than	ADP	IN	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	which	which	PRON	WDT	PronType=Rel	_	_	_	_
47	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	normally	normally	ADV	RB	_	_	_	_	_
50	competent	competent	ADJ	JJ	Degree=Pos	_	_	_	_
51	for	for	ADP	IN	_	_	_	_	_
52	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	1	1	NUM	CD	NumType=Card	_	_	_	_
55	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4758
# text = When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	ligated	ligate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
23	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
24	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
42	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
45	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4759
# text = Document 00300197 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300197	00300197	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4760
# text = Interaction of HTLV-I Tax with the human proteasome: implications for NF-kappa B induction.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4761
# text = The human T-cell leukemia virus type I (HTLV-I) has been etiologically associated with the development of the adult T-cell leukemia (ATL) as well as degenerative neurologic syndrome termed tropical spastic paraparesis (TSP).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	etiologically	etiologically	ADV	RB	_	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	development	development	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
24	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	ATL	ATL	INTJ	UH	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	as	as	ADV	RB	_	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	degenerative	degenerative	ADJ	JJ	Degree=Pos	_	_	_	_
34	neurologic	neurologic	ADJ	JJ	Degree=Pos	_	_	_	_
35	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
36	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	tropical	tropical	ADJ	JJ	Degree=Pos	_	_	_	_
38	spastic	spastic	ADJ	JJ	Degree=Pos	_	_	_	_
39	paraparesis	paraparesis	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TSP	TSP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4762
# text = HTLV-I encodes a potent transactivator protein termed Tax that appears to play an important role in the process of T-cell immortalization.
1	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
9	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	process	process	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4763
# text = Even though the mechanisms by which Tax induces transformation are still unknown, it seems likely that the ability of Tax to alter the expression of many cellular genes plays an important part in this process.
1	Even	even	ADV	RB	_	_	_	_	_
2	though	though	SCONJ	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	DET	WDT	PronType=Int	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	still	still	ADV	RB	_	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
28	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
33	part	part	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
36	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4764
# text = Tax does not bind directly to DNA but rather deregulates the activity of cellular transcription factors.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
5	directly	directly	ADV	RB	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	rather	rather	ADV	RB	_	_	_	_	_
10	deregulates	deregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4765
# text = One family of host transcription factors whose activity is altered by Tax includes NF-kappa B/Rel.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	host	host	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
13	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4766
# text = These transcription factors are post-transcriptionally regulated by their assembly with a second family of inhibitory proteins termed I kappa B that serve to sequester the NF-kappa B/Rel complexes in the cytoplasm.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	post	post	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	-transcriptionally	-transcriptionally	ADV	RB	_	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	serve	serve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	sequester	sequester	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
33	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4767
# text = Upon cellular activation, I kappa B alpha is phosphorylated, polyubiquitinated, and degraded in the proteasome.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	polyubiquitinated	polyubiquitinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4768
# text = This proteolytic event liberates NF-kappa B, permitting its rapid translocation into the nucleus where it binds to its cognate enhancer elements.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	_
4	liberates	liberate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	permitting	permitt	VERB	VBG	VerbForm=Ger	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	into	into	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
17	where	where	ADV	WRB	PronType=Rel	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4769
# text = Similarly, the p105 precursor of the NF-kappa B p50 subunit is also post-translationally processed in the proteasome.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
5	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	p50	p50	NUM	CD	NumType=Card	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	post	post	X	AFX	_	_	_	_	SpaceAfter=No
17	-translationally	-translationally	ADV	RB	_	_	_	_	_
18	processed	process	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4770
# text = The mechanisms by which Tax activates NF-kappa B remain unclear, and findings presented in the literature are often controversial.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
16	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	literature	literature	NOUN	NN	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	often	often	ADV	RB	_	_	_	_	_
22	controversial	controversial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4771
# text = We identified a physical interaction between Tax and the HsN3 subunit of the human proteasome.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HsN3	HsN3	NOUN	NN	Number=Sing	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4772
# text = This raises the intriguing possibility that physical association of the HsN3 proteasome subunit with HTLV-I Tax coupled with the independent interaction of Tax with either p100 or p65-I kappa B alpha targets these cytoplasmic NF-kappa B/Rel complexes to the proteasome for processing.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	raises	rais	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	intriguing	intrigue	VERB	VBG	VerbForm=Ger	_	_	_	_
5	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
8	association	association	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HsN3	HsN3	NUM	CD	NumType=Card	_	_	_	_
12	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
19	coupled	couple	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
23	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	either	either	CCONJ	CC	_	_	_	_	_
28	p100	p100	NUM	CD	NumType=Card	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-I	-i	ADJ	JJ	Degree=Pos	_	_	_	_
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	alpha	alpha	ADP	IN	_	_	_	_	_
35	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
38	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
44	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	_
48	for	for	ADP	IN	_	_	_	_	_
49	processing	processing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4773
# text = Document 003001103 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001103	003001103	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4774
# text = Angiotensin II activates the proinflammatory transcription factor nuclear factor-kappaB in human monocytes.
1	Angiotensin	Angiotensin	PROPN	NNP	Number=Sing	_	_	_	_
2	II	II	PROPN	NNP	Number=Sing	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4775
# text = The renin-angiotensin system may contribute to the pathogenesis of atherosclerosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	renin-	renin-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	angiotensin	angiotensin	ADJ	JJ	Degree=Pos	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4776
# text = A common feature of all stages of atherosclerosis is inflammation of the vessel wall.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
3	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	all	all	DET	DT	_	_	_	_	_
6	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	vessel	vessel	NOUN	NN	Number=Sing	_	_	_	_
14	wall	wall	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4777
# text = The transcription factor nuclear factor-kappaB (NF-kappaB) participates in most signaling pathways involved in inflammation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	participates	participate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
15	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4778
# text = This study therefore examined the effect of angiotensin (ANG) II on NF-kappaB activation in monocytic cells, a major cellular component of human atheroma, by electrophoretic mobility shift assay.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	angiotensin	angiotensin	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	ANG	ANG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
24	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	component	component	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	atheroma	atheroma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
33	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
34	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4779
# text = ANG
1	ANG	ang	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4780
# text = II, like TNFalpha, caused rapid activation of NF-kappaB in human mononuclear cells isolated from peripheral blood by Ficoll density gradient.
1	II	ii	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	like	like	ADP	IN	_	_	_	_	_
4	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	Ficoll	Ficoll	ADJ	JJ	Degree=Pos	_	_	_	_
23	density	density	NOUN	NN	Number=Sing	_	_	_	_
24	gradient	gradient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4781
# text = This ANG II effect was blocked by the angiotensin AT1 receptor antagonist losartan.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	ANG	Ang	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	angiotensin	angiotensin	NOUN	NN	Number=Sing	_	_	_	_
10	AT1	AT1	NUM	CD	NumType=Card	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
13	losartan	losartan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4782
# text = Specificity of ANG II-induced NF-kappaB activation was ascertained by supershift and competition experiments.
1	Specificity	Specificity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ANG	ANG	PROPN	NNP	Number=Sing	_	_	_	_
4	II	II	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	ascertained	ascertain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
17	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4783
# text = Moreover, ANG II stimulated NF-kappaB activation in human monocytes, but not in lymphocytes from the same preparation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ANG	ang	PRON	NN	Number=Sing	_	_	_	_
4	II	ii	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
21	preparation	preparation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4784
# text = Together, the data demonstrate the ability of the vasoactive peptide ANG II to activate inflammatory pathways in human monocytes.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	vasoactive	vasoactive	ADJ	JJ	Degree=Pos	_	_	_	_
11	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
12	ANG	Ang	PROPN	NNP	Number=Sing	_	_	_	_
13	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4785
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press	Press	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4786
# text = Document 003001108 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001108	003001108	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4787
# text = X-rays-induced secretion of cellular factor(s) that enhance(s) HIV-1 promoter transcription in various non-irradiated transfected cell lines.
1	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	rays	ray	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	s	s	X	AFX	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	s	s	X	AFX	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
25	non-irradiated	non-irradiated	ADJ	JJ	Degree=Pos	_	_	_	_
26	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4788
# text = Various cellular stress agents like ionizing radiation exposure could activate human immunodeficiency virus type 1 (HIV- 1) replication or reporter gene expression.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
4	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
5	like	like	SCONJ	IN	_	_	_	_	_
6	ionizing	ionize	VERB	VBG	VerbForm=Ger	_	_	_	_
7	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	_
8	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4789
# text = In addition, extracellular factor(s) released by X-ray-treated human colonic carcinoma cell line (HT29) might activate the long terminal repeat (LTR) of HIV-1 in non-irradiated HT29 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	extracellular	extracelular	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	s	s	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	ray	ray	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	colonic	colonic	NOUN	NN	Number=Sing	_	_	_	_
18	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HT29	HT29	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
25	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	non-irradiated	non-irradiated	ADJ	JJ	Degree=Pos	_	_	_	_
39	HT29	HT29	NUM	CD	NumType=Card	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4790
# text = In the present report we show that in various transiently or stably transfected cell lines, X-ray irradiation up-regulates HIV-1 LTR transcription through the kappaB regulatory elements.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	report	report	NOUN	NN	Number=Sing	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
10	transiently	transiently	ADV	RB	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	stably	stably	ADV	RB	_	_	_	_	_
13	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	X	x	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	ray	ray	NOUN	NN	Number=Sing	_	_	_	_
20	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
21	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	through	through	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
32	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4791
# text = A factor(s), which is processed by and acts upon a variety of cell types, was detected by addition to non-irradiated cells of either X-ray-treated cells or a conditioned medium taken from irradiated cultures.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	processed	process	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	upon	upon	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	non-irradiated	non-irradiate	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	either	either	CCONJ	CC	_	_	_	_	_
29	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	ray	ray	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
39	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	irradiated	irradiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4792
# text = The magnitude of responsiveness is cell type dependent.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4793
# text = In addition, X-ray activation of HIV-1 LTR in transiently or stably transfected cell lines is inhibited by a potent antioxidant drug, pyrrolidine dithiocarbamate and by another drug, known for its role in the trapping of growth factors, suramin.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	ray	ray	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transiently	transiently	ADV	RB	_	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	stably	stably	ADV	RB	_	_	_	_	_
17	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
25	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
26	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	pyrrolidine	pyrrolidine	PRON	PRP	_	_	_	_	_
29	dithiocarbamate	dithiocarbamate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	another	another	DET	DT	_	_	_	_	_
33	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	role	role	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	trapping	trapping	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
44	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	suramin	suramin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4794
# text = The importance of these observations in the pathophysiology of patients with AIDS-related cancers treated by radiotherapy remains to be established.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
15	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	radiotherapy	radiotherapy	NOUN	NN	Number=Sing	_	_	_	_
19	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4795
# text = Document 003001111 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001111	003001111	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4796
# text = Novel therapies for inflammatory bowel disease.
1	Novel	novel	PROPN	NNP	Number=Sing	_	_	_	_
2	therapies	therapy	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
6	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4797
# text = Looking back at successes and failures in newer approaches to treating IBD, it is tempting--although still difficult--to draw conclusions about pathogenesis.
1	Looking	look	VERB	VBG	VerbForm=Ger	_	_	_	_
2	back	back	ADV	RB	_	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	successes	success	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	failures	failure	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	newer	newer	ADJ	JJR	Degree=Cmp	_	_	_	_
9	approaches	approach	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	SCONJ	IN	_	_	_	_	_
11	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
12	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	tempting	tempt	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
17	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
18	although	although	SCONJ	IN	_	_	_	_	_
19	still	still	ADV	RB	_	_	_	_	_
20	difficult	difficult	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
22	to	to	PART	TO	_	_	_	_	_
23	draw	draw	VERB	VB	VerbForm=Inf	_	_	_	_
24	conclusions	conclusion	NOUN	NNS	Number=Plur	_	_	_	_
25	about	about	ADP	IN	_	_	_	_	_
26	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4798
# text = When a therapy proves effective, do clinicians truly know how it works?
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
4	proves	prove	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	clinicians	clinician	NOUN	NNS	Number=Plur	_	_	_	_
9	truly	truly	ADV	RB	_	_	_	_	_
10	know	know	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	how	how	ADV	WRB	PronType=Int	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	works	work	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
14	?	?	PUNCT	.	_	_	_	_	_

# sent_id = 4799
# text = Even with a therapy as specific as anti-TNF antibody, it is not clear if the benefit is attributable to simple binding and clearance of TNF-alpha or to binding on the cell surface and subsequent deletion of the activated macrophage.
1	Even	even	ADV	RB	_	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
9	-TNF	-tnf	ADJ	JJ	Degree=Pos	_	_	_	_
10	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
16	if	if	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	benefit	benefit	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	simple	simple	VERB	VB	VerbForm=Inf	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	to	to	SCONJ	IN	_	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	on	on	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
39	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4800
# text = When a drug appears to be less effective than preclinical models suggest, can failures in effectiveness from delivery or dosing be differentiated?
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
8	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
9	than	than	ADP	IN	_	_	_	_	_
10	preclinical	preclinical	ADJ	JJ	Degree=Pos	_	_	_	_
11	models	model	NOUN	NNS	Number=Plur	_	_	_	_
12	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	failures	failure	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	effectiveness	effectiveness	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	delivery	delivery	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	dosing	dosing	NOUN	NN	Number=Sing	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	?	?	PUNCT	.	_	_	_	_	_

# sent_id = 4801
# text = The disappointing results of clinical trials with IL-10--so at odds with the prediction of benefit from animal models--bring into question the validity of those models as well as the soundness of design of the clinical trials on which efficacy of IL-10 is judged.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	disappointing	disappointing	NOUN	NN	Number=Sing	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
6	trials	trial	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
12	so	so	ADV	RB	_	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	odds	odd	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	prediction	prediction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	benefit	benefit	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
22	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
24	bring	br	VERB	VBG	VerbForm=Ger	_	_	_	_
25	into	into	ADP	IN	_	_	_	_	_
26	question	question	NOUN	NN	Number=Sing	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	validity	validity	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	models	model	NOUN	NNS	Number=Plur	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	soundness	soundness	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	design	design	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
42	trials	trial	NOUN	NNS	Number=Plur	_	_	_	_
43	on	on	ADP	IN	_	_	_	_	_
44	which	which	DET	WDT	PronType=Int	_	_	_	_
45	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
49	10	10	NUM	CD	NumType=Card	_	_	_	_
50	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
51	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4802
# text = The variability of response even to the most narrowly targeted agents suggests that these diseases are far more heterogeneous in humans than in their murine counterparts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	variability	variability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	even	even	ADV	RB	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	most	most	ADV	RBS	_	_	_	_	_
9	narrowly	narrowly	ADV	RB	_	_	_	_	_
10	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
12	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	far	far	ADV	RB	Degree=Pos	_	_	_	_
18	more	more	ADV	RBR	_	_	_	_	_
19	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
26	counterparts	counterpart	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4803
# text = Clinicians are only just beginning to recognize subclinical markers of response, and it may soon be possible to predict response on the basis of genetic composition.
1	Clinicians	Clinician	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	just	just	ADV	RB	_	_	_	_	_
5	beginning	begin	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	recognize	recognize	VERB	VB	VerbForm=Inf	_	_	_	_
8	subclinical	subclinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	soon	soon	ADV	RB	Degree=Pos	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	predict	predict	VERB	VB	VerbForm=Inf	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
27	composition	composition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4804
# text = For the moment, however, the field of pharmacogenetics is embryonic.
1	For	for	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	moment	moment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	field	field	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	pharmacogenetics	pharmacogenetic	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4805
# text = Challenges in developing new therapeutic strategies include not only identifying novel agents, but also improving the definitions of clinical endpoints and defining efficacy at the biologic level.
1	Challenges	challenge	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	SCONJ	IN	_	_	_	_	_
3	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
6	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
7	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	identifying	identify	VERB	VBG	VerbForm=Ger	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	improving	improve	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	definitions	definition	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
21	endpoints	endpoint	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	defining	define	VERB	VBG	VerbForm=Ger	_	_	_	_
24	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
28	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4806
# text = Only through considered evaluation of clinical evidence may clinicians determine which therapies should remain novelties and which should become an accepted part of the armamentarium.
1	Only	only	ADV	RB	_	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	evaluation	evaluation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	clinicians	clinician	NOUN	NNS	Number=Plur	_	_	_	_
10	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
11	which	which	DET	WDT	PronType=Int	_	_	_	_
12	therapies	therapy	NOUN	NNS	Number=Plur	_	_	_	_
13	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
14	remain	remain	VERB	VB	VerbForm=Inf	_	_	_	_
15	novelties	novelty	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Int	_	_	_	_
18	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
19	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	accepted	accept	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	part	part	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	armamentarium	armamentarium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4807
# text = Document 003001112 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001112	003001112	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4808
# text = TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).
1	TRAMP	TRAMP	SYM	NFP	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediating	mediating	VERB	VBG	VerbForm=Ger	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	Apo-1/CD95	Apo-1/CD95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4809
# text = A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	member	member	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	TRAMP	Tramp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4810
# text = The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
3	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	393	393	NUM	CD	NumType=Card	_	_	_	_
7	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
8	acid	acid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	long	long	ADV	RB	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	TRAMP	Tramp	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	most	most	ADV	RBS	_	_	_	_	_
14	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4811
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4812
# text = TRAMP is abundantly expressed on thymocytes and lymphocytes.
1	TRAMP	Tramp	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	abundantly	abundantly	ADV	RB	_	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4813
# text = Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
2	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	four	four	NUM	CD	NumType=Card	_	_	_	_
9	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	death	death	NOUN	NN	Number=Sing	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
25	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4814
# text = Overexpression of TRAMP leads to two major responses, NF-kappaB activation and apoptosis.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TRAMP	TRAMP	NOUN	NN	Number=Sing	_	_	_	_
4	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
8	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4815
# text = TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2.
1	TRAMP	TRAMp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	death	death	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ICE	ice	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	like	like	ADP	IN	_	_	_	_	_
15	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4816
# text = In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TRAMP	TRAMP	NOUN	NN	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	any	any	DET	DT	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4817
# text = Document 003001115 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001115	003001115	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4818
# text = Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils.
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p38alpha	p38alpha	NOUN	NN	Number=Sing	_	_	_	_
8	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-activated	-activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4819
# text = Activation of leukocytes by proinflammatory stimuli selectively initiates intracellular signal transduction via sequential phosphorylation of kinases.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
7	selectively	selectively	ADV	RB	_	_	_	_	_
8	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	sequential	sequential	ADJ	JJ	Degree=Pos	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4820
# text = Lipopolysaccharide (LPS) stimulation of human neutrophils is known to result in activation of p38 mitogen-activated protein kinase (MAPk); however, the upstream activator(s) of p38 MAPk is unknown, and consequences of p38 MAPk activation remain largely undefined.
1	Lipopolysaccharide	Lipopolysaccharide	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	p38	p38	NUM	CD	NumType=Card	_	_	_	_
17	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	;	;	PUNCT	,	_	_	_	_	_
26	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
30	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	s	s	X	AFX	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	p38	p38	NUM	CD	NumType=Card	_	_	_	_
36	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	consequences	consequences	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	p38	p38	NUM	CD	NumType=Card	_	_	_	_
44	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	largely	largely	ADV	RB	_	_	_	_	_
48	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4821
# text = We investigated the MAPk kinase (MKK) that activates p38 MAPk in response to LPS, the p38 MAPk isoforms that are activated as part of this pathway, and the functional responses affected by p38 MAPk activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	MKK	MKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	p38	p38	NUM	CD	NumType=Card	_	_	_	_
12	MAPk	MAPk	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	p38	p38	NUM	CD	NumType=Card	_	_	_	_
20	MAPk	MAPk	NOUN	NN	Number=Sing	_	_	_	_
21	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	part	part	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
34	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
35	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	p38	p38	NUM	CD	NumType=Card	_	_	_	_
38	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4822
# text = Although MKK3, MKK4, and MKK6 all activated p38 MAPk in experimental models, only MKK3 was found to activate recombinant p38 MAPk in LPS-treated neutrophils.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	MKK3	MKK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	MKK4	MKK4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	MKK6	MKK6	PROPN	NNP	Number=Sing	_	_	_	_
8	all	all	ADV	RB	_	_	_	_	_
9	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	p38	p38	NUM	CD	NumType=Card	_	_	_	_
11	MAPk	MAPk	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
14	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	MKK3	MKK3	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
22	recombinant	recombinant	ADV	RB	_	_	_	_	_
23	p38	p38	NUM	CD	NumType=Card	_	_	_	_
24	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4823
# text = Of p38 MAPk isoforms studied, only p38alpha and p38delta were detected in neutrophils.
1	Of	of	ADP	IN	_	_	_	_	_
2	p38	p38	NUM	CD	NumType=Card	_	_	_	_
3	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	_
4	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
5	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	p38alpha	p38alpha	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	p38delta	p38delta	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4824
# text = LPS stimulation selectively activated p38alpha.
1	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	selectively	selectively	ADV	RB	_	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	p38alpha	p38alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4825
# text = Specific inhibitors of p38alpha MAPk blocked LPS-induced adhesion, nuclear factor-kappa B (NF-kappaB) activation, and synthesis of tumor necrosis factor-alpha (TNF-alpha).
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p38alpha	p38alpha	PROPN	NNP	Number=Sing	_	_	_	_
5	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	_
6	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
28	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4826
# text = Inhibition of p38alpha MAPk resulted in a transient decrease in TNF-alpha mRNA accumulation but persistent loss of TNF-alpha synthesis.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	p38alpha	p38alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
15	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
18	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4827
# text = These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3, which in turn activates p38alpha MAPk, ultimately regulating adhesion, NF-kappaB activation, enhanced gene expression of TNF-alpha, and regulation of TNF-alpha synthesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
12	results	result	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	MKK3	MKK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
21	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
22	p38alpha	p38alpha	ADP	IN	_	_	_	_	_
23	MAPk	MAPk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	ultimately	ultimately	ADV	RB	_	_	_	_	_
26	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
48	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4828
# text = Document 003001117 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001117	003001117	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4829
# text = Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.
1	Thrombin	Thrombin	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	thrombin	thrombin	ADP	IN	_	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
6	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
7	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
18	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	CD69	CD69	PROPN	NNP	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4830
# text = Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i.
1	Thrombin	Thrombin	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4831
# text = Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i.
1	Proteolytic	Proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	since	since	ADP	IN	_	_	_	_	_
12	diisopropyl	diisopropyl	ADJ	JJ	Degree=Pos	_	_	_	_
13	fluorophosphate	fluorophosphate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
16	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
22	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4832
# text = Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	hirudin	hirudin	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	anti-thrombin	anti-thrombin	ADJ	JJ	Degree=Pos	_	_	_	_
6	III	III	PROPN	NNP	Number=Sing	_	_	_	_
7	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	thrombin-	thrombin-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
14	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	rise	rise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4833
# text = A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for [Ca2+]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
3	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
6	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TRP	TRP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	7	7	NUM	CD	NumType=Card	_	_	_	_
12	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	SFLLRNP	SFLLRNP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	as	as	ADV	RB	_	_	_	_	_
21	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	thrombin	thrombin	ADP	IN	_	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
28	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	both	both	DET	DT	_	_	_	_	_
34	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	Ca2	ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	+	+	SYM	SYM	_	_	_	_	_
38	release	release	NOUN	NN	Number=Sing	_	_	_	_
39	exclusively	exclusively	ADV	RB	_	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
42	stores	store	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4834
# text = Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40, 42, 70, 120, and 130 kDa.
1	Thrombin	Thrombin	ADP	IN	_	_	_	_	_
2	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
10	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
11	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	42	42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	120	120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	130	130	NUM	CD	NumType=Card	_	_	_	_
21	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4835
# text = There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	good	good	ADJ	JJ	Degree=Pos	_	_	_	_
5	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	thrombin	thrombin	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
15	three	three	NUM	CD	NumType=Card	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4836
# text = Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane.
1	Thrombin	Thrombin	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	TRP	TRP	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	C	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4837
# text = As a likely consequence of these events, thrombin activated the nuclear factor NF-kB.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
4	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	thrombin	thrombin	ADV	RB	_	_	_	_	_
10	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kB.	kB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 4838
# text = Several cell lines of hematopoietic origin including the leukemic
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
6	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
7	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	leukemic	leukemic	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4839
# text = T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin, whereas others such as THP1, a myelomonocytic cell line, and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	line	line	NOUN	NN	Number=Sing	_	_	_	_
4	HPB.ALL	Hpb.all	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroleukemic	erythroleukemic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	K562	K562	NUM	CD	NumType=Card	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	thrombin	thrombin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	others	other	NOUN	NNS	Number=Plur	_	_	_	_
18	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	THP1	tHP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	BL2	Bl2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	refractory	refractory	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	thrombin	thrombin	VERB	VB	VerbForm=Inf	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	TRP	Trp	VERB	VB	VerbForm=Inf	_	_	_	_
39	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4840
# text = The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	thrombin	thrombin	ADJ	JJ	Degree=Pos	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	types	type	NOUN	NNS	Number=Plur	_	_	_	_
12	paralleled	parallel	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4841
# text = We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
22	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
36	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	thrombin	thrombin	ADJ	JJ	Degree=Pos	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4842
# text = Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	TRP	Trp	NOUN	NN	Number=Sing	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CD69	Cd69	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4843
# text = These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	highlight	highlight	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4844
# text = Document 003001118 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001118	003001118	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4845
# text = The Oct-2 transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4846
# text = The Oct-2 transcription factor is a member of the POU (Pit-Oct-Unc) family of transcription factors and is expressed only in B lymphocytes and in neuronal cells but not in other cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	member	member	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	POU	POU	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Pit	pit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Unc	Unc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	neuronal	neuronal	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4847
# text = The primary RNA transcript of the gene is subject to alternative splicing to yield different variants which can either activate or repress gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
4	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
12	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	yield	yield	VERB	VB	VerbForm=Inf	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	either	either	ADV	RB	_	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
23	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4848
# text = The forms produced in B lymphocytes have a predominantly activating effect on gene expression whereas those produced in neuronal cells have a predominantly inhibitory effect and can repress the expression of both the herpes simplex virus immediate-early genes and the cellular tyrosine hydroxylase gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
3	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	predominantly	predominantly	ADV	RB	_	_	_	_	_
10	activating	activat	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	neuronal	neuronal	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	predominantly	predominantly	ADV	RB	_	_	_	_	_
24	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
25	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
28	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	both	both	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	herpes	herpe	NOUN	NN	Number=Sing	_	_	_	_
35	simplex	simplex	NOUN	NN	Number=Sing	_	_	_	_
36	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
37	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
44	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
45	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4849
# text = Thus Oct-2 plays an important role in the regulation of cellular gene expression in both B cells and neuronal cells as well as in the control of viral latency.
1	Thus	thus	PROPN	NNP	Number=Sing	_	_	_	_
2	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	neuronal	neuronal	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	as	as	ADV	RB	_	_	_	_	_
24	well	well	ADV	RB	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	control	control	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
31	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4850
# text = Document 003001119 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001119	003001119	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4851
# text = Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes.
1	Interactions	Interaction	NOUN	NNS	Number=Plur	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	class	class	NOUN	NN	Number=Sing	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4852
# text = Class II major histocompatibility (class II) genes are regulated in a B-cell-specific and gamma interferon-inducible fashion.
1	Class	class	NOUN	NN	Number=Sing	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	_
3	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
4	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
23	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4853
# text = The master switch for the expression of these genes is the class II transactivator (CIITA).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	master	master	NOUN	NN	Number=Sing	_	_	_	_
3	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4854
# text = In this report, we demonstrate that one of the functions of CIITA is to recruit the CREB binding protein (CBP) to class II promoters.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	recruit	recruit	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	class	class	VERB	VB	VerbForm=Inf	_	_	_	_
26	II	ii	NUM	CD	NumType=Card	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4855
# text = Not only functional but also specific binding interactions between CIITA and CBP were demonstrated.
1	Not	not	ADV	RB	_	_	_	_	_
2	only	only	ADV	RB	_	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4856
# text = Moreover, a dominant negative form of CBP decreased the activity of class II promoters and levels of class II determinants on the surface of cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	_
9	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	class	class	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	_
15	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4857
# text = Finally, the inhibition of class II gene expression by the glucocorticoid hormone could be attributed to the squelching of CBP by the glucocorticoid receptor.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	squelching	squelching	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4858
# text = We conclude that CBP, a histone acetyltransferase, plays an important role in the transcription of class II genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	CBP	CBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
8	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4859
# text = Document 003001123 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001123	003001123	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4860
# text = The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
3	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
4	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD34	Cd34	PROPN	NNP	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4861
# text = MZF-1 is a C2H2 zinc finger gene encoding a putative transcriptional regulator of myeloid differentiation.
1	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	C2	c2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	H2	H2	NOUN	NN	Number=Sing	_	_	_	_
8	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
9	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4862
# text = The MZF-1 protein contains 13 C2H2 zinc fingers arranged in bipartite DNA binding domains containing zinc fingers through 4 and, in the carboxy-terminus, 5 through 13.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	MZF	Mzf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	13	13	NUM	CD	NumType=Card	_	_	_	_
8	C2	C2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	H2	H2	NUM	CD	NumType=Card	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
11	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
12	arranged	arrange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	bipartite	bipartite	NOUN	NN	Number=Sing	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
20	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	5	5	NUM	CD	NumType=Card	_	_	_	_
32	through	through	ADP	IN	_	_	_	_	_
33	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4863
# text = We previously identified the DNA consensus binding site recognized by the two DNA binding domains.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4864
# text = To assess the transcription regulatory function of MZF-1, the full-length MZF-1 coding region was fused to the DNA binding domain of the yeast transactivator GAL4.
1	To	to	PART	TO	_	_	_	_	_
2	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	length	length	NOUN	NN	Number=Sing	_	_	_	_
16	MZF	Mzf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
31	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
32	GAL4	Gal4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4865
# text = The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3, 293, K562, and Jurkat cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
9	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
10	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	GAL4	GAL4	NUM	CD	NumType=Card	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	into	into	ADP	IN	_	_	_	_	_
28	NIH	NIh	DET	DT	_	_	_	_	_
29	3T3	3T3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	293	293	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	K562	k562	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4866
# text = MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293.
1	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	represses	represse	NOUN	NNS	Number=Plur	_	_	_	_
5	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
6	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	via	via	ADP	IN	_	_	_	_	_
10	GAL4	GAL4	NUM	CD	NumType=Card	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nonhematopoietic	nonhematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	NIH	NIH	PROPN	NNP	Number=Sing	_	_	_	_
19	3T3	3T3	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	293	293	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4867
# text = In contrast, MZF-1 activates CAT reporter gene expression in the hematopoietic cell lines K562 and Jurkat.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
8	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
17	K562	K562	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4868
# text = The MZF-1 binding sites are present in the promoters of several genes expressed during myeloid differentiation, including the CD34 promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	MZF	MZF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4869
# text = MZF-1 transcriptional regulation of this physiologically relevant promoter was assessed in both hematopoietic and nonhematopoietic cell lines.
1	MZF	Mzf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	physiologically	physiologically	ADV	RB	_	_	_	_	_
9	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	nonhematopoietic	nonhematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4870
# text = Recombinant MZF-1 protein specifically binds to the consensus binding sites in the CD34 promoter in mobility shift assays.
1	Recombinant	Recombinant	PROPN	NNP	Number=Sing	_	_	_	_
2	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	specifically	specifically	ADV	RB	_	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
19	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
20	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4871
# text = MZF-1 expression vectors were cotransfected with the luciferase reporter plasmids regulated by the CD34 promoter into both nonhematopoietic and hematopoietic cell lines.
1	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	luciferase	luciferase	ADJ	JJ	Degree=Pos	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	nonhematopoietic	nonhematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4872
# text = As with the heterologous DNA binding domain, MZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines.
1	As	as	ADP	IN	_	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	represses	represse	NOUN	NNS	Number=Plur	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	nonhematopoietic	nonhematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4873
# text = Activation of CD34 expression in hematopoietic cell lines is dependent on the presence of intact MZF-1 binding sites.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD34	CD34	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
16	MZF	MZF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4874
# text = The cell type-specific regulation of the CD34 promoter by MZF-1 suggests the presence of tissue-specific regulators/adapters or differential MZF-1 modifications that determine MZF-1 transcriptional regulatory function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	adapters	adapter	NOUN	NNS	Number=Plur	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
27	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	determine	determine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	MZF	MZF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
38	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4875
# text = Document 003001126 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001126	003001126	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4876
# text = A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p [see comments]
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
3	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
4	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
11	Rpd3	Rpd3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	p	p	NOUN	NN	Number=Sing	_	_	_	_
13	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
15	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4877
# text = Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle.
1	Trapoxin	Trapoxin	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	microbially	microbially	ADV	RB	_	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cyclotetrapeptide	cyclotetrapeptide	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
10	deacetylation	deacetylation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	arrest	arrest	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4878
# text = A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	trapoxin	trapoxin	NOUN	NN	Number=Sing	_	_	_	_
3	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
4	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	copurified	copurify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
16	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4879
# text = Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library.
1	Both	both	DET	DT	_	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
7	microsequencing	microsequencing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
16	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
17	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HD1	Hd1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4880
# text = As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.
1	As	as	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	very	very	ADV	RB	_	_	_	_	_
7	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
13	Rpd3	Rpd3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	results	result	NOUN	NNS	Number=Plur	_	_	_	_
18	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
23	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
27	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4881
# text = Document 003001130 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001130	003001130	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4882
# text = BCL-6 expression during B-cell activation.
1	BCL	Bcl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4883
# text = Translocations involving the BCL-6 gene are common in the diffuse large cell subtype of non-Hodgkin's lymphoma.
1	Translocations	Translocation	NOUN	NNS	Number=Plur	_	_	_	_
2	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	diffuse	diffuse	NOUN	NN	Number=Sing	_	_	_	_
13	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	subtype	subtype	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	non-Hodgkin	non-Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	's	's	PART	POS	_	_	_	_	_
19	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4884
# text = Invariably, the BCL-6 coding region is intact, but its 5' untranslated region is replaced with sequences from the translocation partner.
1	Invariably	Invariably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
14	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	``	_	_	_	_	_
17	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
26	partner	partner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4885
# text = The present study shows that BCL-6 expression is regulated in lymphocytes during mitogenic stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	shows	show	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	BCL	Bcl	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4886
# text = Resting B and T lymphocytes contain high levels of BCL-6 mRNA.
1	Resting	rest	PROPN	NNP	Number=Sing	_	_	_	_
2	B	b	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	mRNA.	mRNA.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4887
# text = Stimulation of mouse B cells with anti-IgM or IgD antibodies, bacterial lipopolysaccharide, phorbol 12-myristate 13-acetate plus ionomycin, or CD40 ligand led to a five-fold to 35-fold decrease in BCL-6 mRNA levels.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	anti-IgM	anti-Igm	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IgD	igd	NOUN	NN	Number=Sing	_	_	_	_
10	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
13	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
22	plus	plus	CCONJ	CC	_	_	_	_	_
23	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
27	ligand	ligand	PROPN	NNP	Number=Sing	_	_	_	_
28	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	five	five	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
38	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	6	6	NUM	CD	NumType=Card	_	_	_	_
43	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
44	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4888
# text = Similar downregulation of BCL-6 mRNA was seen in human B cells stimulated with Staphylococcus aureus plus interleukin-2 or anti-IgM antibodies and in human T lymphocytes stimulated with phytohemagglutinin.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	Staphylococcus	Staphylococcus	PROPN	NNP	Number=Sing	_	_	_	_
17	aureus	aureus	NOUN	NN	Number=Sing	_	_	_	_
18	plus	plus	CCONJ	CC	_	_	_	_	_
19	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	anti-IgM	anti-Igm	ADJ	JJ	Degree=Pos	_	_	_	_
24	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4889
# text = BCL-6 mRNA levels began to decrease 8 to 16 hours after stimulation, before cells entered S phase.
1	BCL	Bcl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	began	begin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	16	16	NUM	CD	NumType=Card	_	_	_	_
12	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	before	before	SCONJ	IN	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	entered	enter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	S	s	PROPN	NNP	Number=Sing	_	_	_	_
20	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4890
# text = Although polyclonal activation of B cells in vitro invariably decreased BCL-6 MRNA expression, activated B cells from human germinal centers expressed BCL-6 mRNA at levels comparable to the levels in resting B cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
9	invariably	invariably	ADV	RB	_	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	MRNA	MRNa	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
23	centers	center	NOUN	NNS	Number=Plur	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	6	6	NUM	CD	NumType=Card	_	_	_	_
28	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	SCONJ	IN	_	_	_	_	_
36	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4891
# text = Despite these similar mRNA levels, BCL-6 protein expression was threefold to 34-fold higher in germinal center B cells than in resting B cells, suggesting that BCL-6 protein levels are controlled by translational or posttranslational mechanisms.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	threefold	threefold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	34	34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
21	center	center	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	than	than	ADP	IN	_	_	_	_	_
25	in	in	SCONJ	IN	_	_	_	_	_
26	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	posttranslational	posttranslational	ADJ	JJ	Degree=Pos	_	_	_	_
43	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4892
# text = These observations suggest that the germinal center reaction provides unique activation signals to B cells that allow for continued, high-level BCL-6 expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
7	center	center	NOUN	NN	Number=Sing	_	_	_	_
8	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
9	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	allow	allow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	continued	continue	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	BCL	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4893
# text = Document 003001134 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001134	003001134	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4894
# text = Involvement of an SAF-like transcription factor in the activation of serum amyloid A gene in monocyte/macrophage cells by lipopolysaccharide.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	SAF	SAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
14	amyloid	amyloid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4895
# text = Serum amyloid A (SAA) has been linked to atherosclerosis because of its ability to remodel high-density lipoprotein by the depletion of apolipoprotein A1, its ability to bind cholesterol, and its presence in the atherosclerotic plaques of coronary and carotid arteries.
1	Serum	Serum	NOUN	NN	Number=Sing	_	_	_	_
2	amyloid	amyloid	NOUN	NN	Number=Sing	_	_	_	_
3	A	a	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	SAA	SAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	because	because	ADP	IN	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	remodel	remodel	VERB	VB	VerbForm=Inf	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	density	density	NOUN	NN	Number=Sing	_	_	_	_
21	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	apolipoprotein	apolipoprotein	NOUN	NN	Number=Sing	_	_	_	_
27	A1	A1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
33	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
37	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
42	plaques	plaque	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	coronary	coronary	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	carotid	carotid	NOUN	NN	Number=Sing	_	_	_	_
47	arteries	artery	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4896
# text = In the present study, we investigated the induction mechanism of SAA gene in THP-1 monocyte/macrophage cells which play a critical role in the development of atherosclerotic fatty streak and plaque formation.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	SAA	SAA	PROPN	NNP	Number=Sing	_	_	_	_
13	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	THP	THP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
32	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
33	streak	streak	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	plaque	plaque	NOUN	NN	Number=Sing	_	_	_	_
36	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4897
# text = We and others have shown that SAA gene is induced in monocyte/macrophage cells by lipopolysaccharide (LPS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	others	other	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	SAA	SAa	PROPN	NNP	Number=Sing	_	_	_	_
8	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4898
# text = By promoter function analysis, we show that the SAA promoter sequence between -280 and -226 can confer LPS responsiveness.
1	By	by	ADP	IN	_	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	SAA	SAA	NOUN	NN	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	280	280	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	226	226	NUM	CD	NumType=Card	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
22	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4899
# text = Gel electrophoretic mobility shift assay detected an induced DNA-binding activity in these cells in response to LPS.
1	Gel	gel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4900
# text = Characterization of the DNA-binding protein by UV cross-linking, Southwestern blot, and antibody ablation/supershift assays revealed that it is similar to a recently reported nuclear factor designated SAF.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
10	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Southwestern	southwestern	ADJ	JJ	Degree=Pos	_	_	_	_
14	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
18	ablation	ablation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
21	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
22	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	recently	recently	ADV	RB	_	_	_	_	_
30	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	SAF	SAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4901
# text = These results demonstrated that LPS-mediated SAA gene induction in monocyte/macrophage cells is primarily due to the induction of SAF activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	SAA	SAa	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	primarily	primarily	ADV	RB	_	_	_	_	_
18	due	due	ADP	IN	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	SAF	SAF	PROPN	NNP	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4902
# text = Document 003001143 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001143	003001143	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4903
# text = Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
17	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_

# sent_id = 4904
# text = I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	b	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	RelA	Rela	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4905
# text = The tax gene product of human T-cell leukemia virus type I (HTLV-I) is a potent transcriptional activator that both stimulates viral gene expression and activates an array of cellular genes involved in T-cell growth.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	both	both	ADV	RB	_	_	_	_	_
25	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	array	array	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4906
# text = Tax acts indirectly by inducing or modifying the action of various host transcription factors, including members of the NF-kappa B/Rel family of enhancer-binding proteins.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	indirectly	indirectly	ADV	RB	_	_	_	_	_
4	by	by	SCONJ	IN	_	_	_	_	_
5	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	modifying	modify	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
12	host	host	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	members	member	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4907
# text = In resting T cells, many of these NF-kappa B/Rel factors are sequestered in the cytoplasm by various ankyrin-rich inhibitory proteins, including I kappa B alpha.
1	In	in	SCONJ	IN	_	_	_	_	_
2	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	ankyrin-	ankyrin-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
25	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4908
# text = HTLV-I Tax expression leads to the constitutive nuclear expression of biologically active NF-kappa B and c-Rel complexes; however, the biochemical mechanism(s) underlying this response remains poorly understood.
1	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	biologically	biologically	ADV	RB	_	_	_	_	_
14	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	;	;	PUNCT	,	_	_	_	_	_
25	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
29	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	s	s	X	AFX	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	poorly	poorly	ADJ	JJ	Degree=Pos	_	_	_	_
38	understood	understand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4909
# text = In this study, we demonstrate that Tax-stimulated nuclear expression of NF-kappa B in both HTLV-I-infected and Tax-transfected human T cells is associated with the phosphorylation and rapid proteolytic degradation of I kappa B alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
39	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
40	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
43	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
44	B	B	PROPN	NNP	Number=Sing	_	_	_	_
45	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4910
# text = In contrast to prior in vitro studies, at least a fraction of the phosphorylated form of I kappa B alpha remains physically associated with the NF-kappa B complex in vivo but is subject to rapid degradation, thereby promoting the nuclear translocation of the active NF-kappa B complex.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	prior	prior	VERB	VB	VerbForm=Inf	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
7	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	at	at	ADV	RB	_	_	_	_	_
10	least	least	ADV	RBS	Degree=Sup	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	ADV	RB	_	_	_	_	_
22	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	physically	physically	ADV	RB	_	_	_	_	_
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
39	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	thereby	thereby	ADV	RB	_	_	_	_	_
42	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
45	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
49	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
52	B	b	NOUN	NN	Number=Sing	_	_	_	_
53	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4911
# text = We further demonstrate that Tax induction of nuclear c-Rel expression is activated by the RelA (p65) subunit of NF-kappa B, which activates transcription of the c-rel gene through an intrinsic kappa B enhancer element.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
34	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	through	through	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
42	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4912
# text = In normal cells, the subsequent accumulation of nuclear c-Rel acts to inhibit its own continued production, indicating the presence of an autoregulatory loop.
1	In	in	ADP	IN	_	_	_	_	_
2	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
7	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
13	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
18	continued	continue	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4913
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4914
# text = Document 003001145 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001145	003001145	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4915
# text = Nitric oxide-stimulated guanine nucleotide exchange on p21ras.
1	Nitric	Nitric	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
6	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
7	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4916
# text = The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
3	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	monomeric	monomeric	ADJ	JJ	Degree=Pos	_	_	_	_
7	G	g	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	converting	converte	VERB	VBG	VerbForm=Ger	_	_	_	_
18	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
20	into	into	ADP	IN	_	_	_	_	_
21	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
23	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4917
# text = Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
7	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NO	no	INTJ	UH	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
26	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4918
# text = In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	pure	pure	ADJ	JJ	Degree=Pos	_	_	_	_
6	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
7	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
8	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4919
# text = Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange.
1	Circular	circular	ADJ	JJ	Degree=Pos	_	_	_	_
2	dichroism	dichroism	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	reveals	reveal	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	NO	no	DET	DT	_	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
10	conformational	conformational	ADJ	JJ	Degree=Pos	_	_	_	_
11	change	change	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	association	association	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	GDP	gdp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/GTP	/gtp	PROPN	NNP	Number=Sing	_	_	_	_
19	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4920
# text = The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	due	due	ADP	IN	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	S-	S-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	nitrosylation	nitrosylation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
13	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
14	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	guanine	guanine	NUM	CD	NumType=Card	_	_	_	_
18	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
19	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4921
# text = Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	p21ras	p21ras	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	NO	no	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
27	NO	no	NOUN	NN	Number=Sing	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
30	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4922
# text = These studies identify p21ras as a target of the same cell.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	target	target	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4923
# text = These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	target	target	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NO	no	DET	DT	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	NO	no	DET	DT	_	_	_	_	_
17	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
18	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	action	action	NOUN	NN	Number=Sing	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	mimics	mimics	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	guanine	guanine	NUM	CD	NumType=Card	_	_	_	_
27	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
28	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4924
# text = Document 003001147 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001147	003001147	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4925
# text = The spatial distribution of human immunoglobulin genes within the nucleus: evidence for gene topography independent of cell type and transcriptional activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	spatial	spatial	ADJ	JJ	Degree=Pos	_	_	_	_
3	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	topography	topography	NOUN	NN	Number=Sing	_	_	_	_
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4926
# text = The three-dimensional positioning of immunoglobulin
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dimensional	dimensional	ADJ	JJ	Degree=Pos	_	_	_	_
5	positioning	positioning	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4927
# text = (Ig) genes within the nucleus of human cells was investigated using in situ hybridization and confocal microscopy.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	X	ADD	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
16	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	confocal	confocal	ADJ	JJ	Degree=Pos	_	_	_	_
19	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4928
# text = The visualization of heavy and light chain genes in B-lymphoid cells showed that the three Ig genes are differentially and nonrandomly distributed in different nuclear subvolumes: the kappa genes were found to be preferentially confined to an outer nuclear volume, whereas the gamma and lambda genes consistently occupied more central positions within the nucleus, the lambda genes being more interior when compared with the gamma genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	visualization	visualization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	light	light	ADJ	JJ	Degree=Pos	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	three	three	NUM	CD	NumType=Card	_	_	_	_
18	Ig	ig	NOUN	NN	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	differentially	differentially	ADV	RB	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	nonrandomly	nonrandomly	ADV	RB	_	_	_	_	_
24	distributed	distribute	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	subvolumes	subvolume	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	preferentially	preferentially	ADV	RB	_	_	_	_	_
38	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	outer	outer	ADJ	JJ	Degree=Pos	_	_	_	_
42	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
43	volume	volume	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	whereas	whereas	SCONJ	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_
50	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
51	consistently	consistently	ADV	RB	_	_	_	_	_
52	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	more	more	ADV	RBR	_	_	_	_	_
54	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
55	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
56	within	within	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_
62	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
63	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
64	more	more	ADV	RBR	_	_	_	_	_
65	interior	interior	ADJ	JJ	Degree=Pos	_	_	_	_
66	when	when	ADV	WRB	PronType=Int	_	_	_	_
67	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
68	with	with	ADP	IN	_	_	_	_	_
69	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
70	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
71	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4929
# text = The data further show that these overall topographical distributions are independent of gene transcriptional activity and are conserved in different cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
8	topographical	topographical	ADJ	JJ	Degree=Pos	_	_	_	_
9	distributions	distribution	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	PRON	NN	Number=Sing	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4930
# text = Although subtle gene movements within those defined topographical regions cannot be excluded by this study, the results indicate that tissue specificity of gene expression is not accompanied by drastic changes in gene nuclear topography, rather suggesting that gene organization within the nucleus may be primarily dependent on structural constraints imposed on the respective chromosomes.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	movements	movement	NOUN	NNS	Number=Plur	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
7	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	topographical	topographical	ADJ	JJ	Degree=Pos	_	_	_	_
9	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
11	not	not	PART	RB	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	excluded	exclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
23	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	drastic	drastic	ADJ	JJ	Degree=Pos	_	_	_	_
32	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
35	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	topography	topography	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	rather	rather	ADV	RB	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
42	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
43	within	within	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
46	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
47	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
48	primarily	primarily	ADV	RB	_	_	_	_	_
49	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
50	on	on	ADP	IN	_	_	_	_	_
51	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
52	constraints	constraint	NOUN	NNS	Number=Plur	_	_	_	_
53	imposed	impose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	on	on	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
57	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4931
# text = Document 003001153 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001153	003001153	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4932
# text = V3 loop of human immunodeficiency virus type 1 suppresses interleukin 2-induced T cell growth [published erratum appears in AIDS Res Hum Retroviruses 1997 May 1;13(7):633]
1	V3	V3	NUM	CD	NumType=Card	_	_	_	_
2	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	_
10	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
20	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
23	Res	res	NOUN	NNS	Number=Plur	_	_	_	_
24	Hum	Hum	PROPN	NNP	Number=Sing	_	_	_	_
25	Retroviruses	Retroviruse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	1997	1997	NUM	CD	NumType=Card	_	_	_	_
27	May	May	PROPN	NNP	Number=Sing	_	_	_	_
28	1;13	1;13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	:633	:633	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4933
# text = We tested the effect of three linear or two loop peptides derived from the V3 region of the HTLV-III BH10 clone or the SF2 strain of human immunodeficiency virus type 1 on IL-2-driven T cell proliferation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	three	three	NUM	CD	NumType=Card	_	_	_	_
7	linear	linear	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	loop	loop	ADJ	JJ	Degree=Pos	_	_	_	_
11	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
12	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	V3	V3	NUM	CD	NumType=Card	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	III	iii	NUM	CD	NumType=Card	_	_	_	_
22	BH10	BH10	NUM	CD	NumType=Card	_	_	_	_
23	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	SF2	Sf2	NOUN	NN	Number=Sing	_	_	_	_
27	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
31	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4934
# text = V3-BH10, which consists of 42 amino acids and has a loop structure, suppressed IL-2-driven proliferation of all IL-2-dependent cells [Kit225, ED-40515(+), KT-3, 7-day PHA-blasts, and fresh peripheral blood mononuclear cells] tested, whereas it did not suppress the cell growth of IL-2-independent cell lines (Hut102, Molt-4, and Jurkat).
1	V3	V3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-BH10	-BH10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	42	42	NUM	CD	NumType=Card	_	_	_	_
8	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
9	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
14	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	all	all	DET	DT	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Kit	Kit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	225	225	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	ED-40515	ED-40515	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	(+)	(+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	KT	KT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	day	day	NOUN	NN	Number=Sing	_	_	_	_
44	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
50	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
51	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
52	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	]	]	PUNCT	-RRB-	_	_	_	_	_
55	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	whereas	whereas	SCONJ	IN	_	_	_	_	_
58	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
59	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
60	not	not	PART	RB	_	_	_	_	_
61	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
64	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
65	of	of	ADP	IN	_	_	_	_	_
66	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
71	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
72	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
73	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
74	Hut	Hut	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	102	102	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
76	,	,	PUNCT	,	_	_	_	_	_
77	Molt	Molt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
78	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
79	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
80	,	,	PUNCT	,	_	_	_	_	_
81	and	and	CCONJ	CC	_	_	_	_	_
82	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
83	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
84	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4935
# text = This suppressive effect was also seen in IL-2-driven cell growth of CD8-positive lymphocytes purified from 7-day PHA-blasts, indicating that CD4 molecules were not required for the suppression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	day	day	NOUN	NN	Number=Sing	_	_	_	_
25	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	_
32	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4936
# text = The treatment with anti-V3 loop monoclonal antibody (902 antibody) completely abolished the suppressive effect of V3-BH10.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
5	-V3	-V3	NUM	CD	NumType=Card	_	_	_	_
6	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
7	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
8	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	902	902	NUM	CD	NumType=Card	_	_	_	_
11	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	V3-	v3-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	BH10	BH10	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4937
# text = In addition, V3-BH10 generated the arrest of Kit225 cells and also purified CD8-positive lymphocytes in G1 phase in the presence of IL-2.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	V3	V3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	BH	Bh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Kit225	Kit225	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	CD8	CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	G1	g1	PROPN	NNP	Number=Sing	_	_	_	_
23	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4938
# text = Neither chromatin condensation nor DNA fragmentation was detected in Kit225 cells cultured with V3-BH10 and IL-2.
1	Neither	neither	DET	DT	_	_	_	_	_
2	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
3	condensation	condensation	NOUN	NN	Number=Sing	_	_	_	_
4	nor	nor	CCONJ	CC	_	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Kit	Kit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	225	225	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	V3-	v3-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	BH10	BH10	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4939
# text = V3-BH10 neither blocked radiolabeled IL-2 binding to IL-2 receptors nor affected tyrosyl phosphorylation of several cellular proteins (p120, p98, p96, p54, and p38), which is immediately induced by IL-2 stimulation.
1	V3	V3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	BH	Bh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	neither	neither	NOUN	NN	Number=Sing	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	radiolabeled	radiolabel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
17	nor	nor	CCONJ	CC	_	_	_	_	_
18	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	tyrosyl	tyrosyl	NOUN	NN	Number=Sing	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
23	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	p120	p120	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	p98	p98	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	p96	p96	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	p54	p54	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	p38	p38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	immediately	immediately	ADV	RB	_	_	_	_	_
41	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4940
# text = However, V3-BH10 enhanced IL-2-induced mRNA expression of c-fos but not c-myc or junB.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	V3	V3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	BH	Bh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	junB	junb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4941
# text = Thus, the binding of V3 loop of gp120 to the cell surface molecule(s) appears to affect intracellular IL-2 signaling, which leads to the suppression of IL-2-induced T cell growth.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	V3	V3	NUM	CD	NumType=Card	_	_	_	_
7	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	gp120	gp120	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	s	s	X	AFX	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
21	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4942
# text = Document 003001156 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001156	003001156	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4943
# text = T cell-specific negative regulation of transcription of the human cytokine IL-4.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4944
# text = IL-4 secreted by activated T cells is a pleiotropic cytokine affecting growth and differentiation of diverse cell types such as T cells, B cells, and mast cells.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	types	type	NOUN	NNS	Number=Plur	_	_	_	_
21	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	mast	mast	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4945
# text = We investigated the upstream regulatory elements of the human IL-4 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4946
# text = A novel T cell-specific negative regulatory element (NRE) composed of two protein-binding sites were mapped in the 5' flanking region of the IL-4 gene: -311CTCCCTTCT-303 (NRE-I) and -288CTTTTTGCTT-TGC-300 (NRE-II).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	composed	compose	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	protein-	protein-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	'	'	PUNCT	``	_	_	_	_	_
25	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	:	:	PUNCT	:	_	_	_	_	_
34	-311CTCCCTTCT-303	-311CTCCCTTCT-303	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	NRE	Nre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	-288CTTTTTGCTT-TGC	-288ctttttgctt-tgc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	300	300	NUM	CD	NumType=Card	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	NRE	Nre	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4947
# text = A T cell-specific protein Neg-1 and a ubiquitous protein Neg-2 binding to NRE-I and NRE-II, respectively, were identified.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	Neg	Neg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	Neg	Neg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4948
# text = Furthermore, a positive regulatory element was found 45 bp downstream of the NRE.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	45	45	NUM	CD	NumType=Card	_	_	_	_
10	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
11	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	NRE	Nre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4949
# text = The enhancer activity of the PRE was completely suppressed when the NRE was present.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PRE	pre	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NRE	Nre	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4950
# text = These data suggest that IL-4 promoter activity is normally down-regulated by an NRE via repression of the enhancer positive regulatory element.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	normally	normally	ADV	RB	_	_	_	_	_
12	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	NRE	Nre	PROPN	NNP	Number=Sing	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4951
# text = These data may have implications for the stringent control of IL-4 expression in T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
5	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	stringent	stringent	ADJ	JJ	Degree=Pos	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4952
# text = Document 003001157 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001157	003001157	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4953
# text = A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	T	t	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
15	without	without	ADP	IN	_	_	_	_	_
16	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
17	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4954
# text = Stimulation of resting human T cells with the CD28-specific mAb BW 828 induces proliferation and cytokine synthesis without further requirement for TCR coengagement.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	SCONJ	IN	_	_	_	_	_
3	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
13	BW	BW	PROPN	NNP	Number=Sing	_	_	_	_
14	828	828	NUM	CD	NumType=Card	_	_	_	_
15	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
20	without	without	ADP	IN	_	_	_	_	_
21	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
22	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	TCR	Tcr	ADJ	JJR	Degree=Cmp	_	_	_	_
25	coengagement	coengagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4955
# text = This observation prompted us to postulate that signal 2 (costimulatory signal) alone without signal 1 (TCR signal) can activate T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	prompted	prompt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	postulate	postulate	VERB	VB	VerbForm=Inf	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	alone	alone	ADV	RB	_	_	_	_	_
15	without	without	ADP	IN	_	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
20	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4956
# text = To test whether this putative function of CD28 is mediated via a particular signaling pathway, we compared early signaling events initiated in resting T cells by the stimulatory mAb BW 828 with signals triggered by the nonstimulating CD28 mAb 9.3. Stimulation of T cells with BW 828 induced an increase in intracellular Ca2+, but did not lead to detectable activation of the protein kinases p56(lck) and c-Raf-1.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	via	via	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	early	early	ADV	RB	Degree=Pos	_	_	_	_
20	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
21	events	event	NOUN	NNS	Number=Plur	_	_	_	_
22	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	SCONJ	IN	_	_	_	_	_
24	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
31	BW	BW	PROPN	NNP	Number=Sing	_	_	_	_
32	828	828	NUM	CD	NumType=Card	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
35	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	nonstimulating	nonstimulating	NOUN	NN	Number=Sing	_	_	_	_
39	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
40	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
41	9.3	9.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_
43	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
47	with	with	ADP	IN	_	_	_	_	_
48	BW	BW	PROPN	NNP	Number=Sing	_	_	_	_
49	828	828	NUM	CD	NumType=Card	_	_	_	_
50	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
55	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	but	but	CCONJ	CC	_	_	_	_	_
59	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
60	not	not	PART	RB	_	_	_	_	_
61	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
62	to	to	ADP	IN	_	_	_	_	_
63	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
64	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
65	of	of	ADP	IN	_	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
68	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
69	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
71	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	)	)	PUNCT	-RRB-	_	_	_	_	_
73	and	and	CCONJ	CC	_	_	_	_	_
74	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
75	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
76	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
77	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4957
# text = This pathway resulted in the induction of the transcription factors NF-kappa B, NF-AT, and proteins binding to the CD28 response element of the IL-2 promoter.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
3	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	element	element	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4958
# text = On the other hand, stimulation of T cells with mAb 9.3 increased the level of intracellular Ca2+ and triggered the activation of p56(lck) and c-Raf-1, but was unable to induce the binding of transcription factors to the IL-2 promoter.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
12	9.3	9.3	NUM	CD	NumType=Card	_	_	_	_
13	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	triggered	trigger	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	2	2	NUM	CD	NumType=Card	_	_	_	_
51	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4959
# text = In contrast to the differential signaling of BW 828 and 9.3 in resting
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	BW	BW	PROPN	NNP	Number=Sing	_	_	_	_
9	828	828	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	9.3	9.3	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	resting	rest	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 4960
# text = T cells, the two mAbs exhibited a similar pattern of early signaling events in activated T cells and Jurkat cells (p56(lck) activation, association of phosphatidylinositol 3-kinase with CD28), indicating that the signaling capacity of CD28 changes with activation.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	mAbs	mAbs	NOUN	NNS	Number=Plur	_	_	_	_
7	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
10	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	association	association	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
43	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
46	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
47	with	with	ADP	IN	_	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4961
# text = These data support the view that stimulation through CD28 can induce some effector functions in T cells and suggest that this capacity is associated with a particular pattern of early signaling events.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	view	view	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
12	some	some	DET	DT	_	_	_	_	_
13	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
14	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
28	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
31	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
32	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4962
# text = Document 003001159 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001159	003001159	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4963
# text = Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C-independent mechanism.
1	Thapsigargin	Thapsigargin	PROPN	NNP	Number=Sing	_	_	_	_
2	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	alpha-	alpha-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	peripheral	peripheral	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4964
# text = Thapsigargin (TG), an inhibitor of Ca(2+)-ATPase, depletes intracellular Ca2+ stores and induces a sustained Ca2+ influx without altering phosphatidyl inositol levels.
1	Thapsigargin	Thapsigargin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TG	TG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	2+)	2+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	ATPase	ATPase	INTJ	UH	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	depletes	deplete	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
17	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	+	+	SYM	SYM	_	_	_	_	_
19	stores	store	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	influx	influx	NOUN	NN	Number=Sing	_	_	_	_
27	without	without	SCONJ	IN	_	_	_	_	_
28	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
29	phosphatidyl	phosphatidyl	NOUN	NN	Number=Sing	_	_	_	_
30	inositol	inositol	NOUN	NN	Number=Sing	_	_	_	_
31	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4965
# text = TG plus phorbol myristate acetate (PMA) but not TG alone induced IL-2 in Jurkat T cells, suggesting that TG had no effect on protein kinase C (PKC).
1	TG	TG	NOUN	NN	Number=Sing	_	_	_	_
2	plus	plus	CCONJ	CC	_	_	_	_	_
3	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
4	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
5	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	TG	TG	VERB	VB	VerbForm=Inf	_	_	_	_
12	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	TG	TG	PROPN	NNP	Number=Sing	_	_	_	_
25	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	no	no	DET	DT	_	_	_	_	_
27	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	C	C	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4966
# text = However, TG induced increases in IL-2R alpha protein as well as IL-2R alpha mRNA in Jurkat T cells in a dose-dependent manner.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TG	TG	VERB	VBG	VerbForm=Ger	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	X	LS	_	_	_	_	SpaceAfter=No
10	R	r	X	GW	_	_	_	_	_
11	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
19	alpha	alpha	ADP	IN	_	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4967
# text = A similar increase in IL-2R alpha by TG was also observed in human peripheral T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	2	2	X	LS	_	_	_	_	SpaceAfter=No
8	R	r	X	GW	_	_	_	_	_
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	TG	TG	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4968
# text = Further, like PMA, TG markedly induced NF kappa B in Jurkat T cells.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	like	like	ADP	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	TG	TG	PROPN	NNP	Number=Sing	_	_	_	_
7	markedly	markedly	ADV	RB	_	_	_	_	_
8	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4969
# text = However, TG and PMA exhibited a synergistic action on IL-2R alpha expression, suggesting that TG and PMA induce IL-2R alpha through distinct pathways.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TG	TG	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
6	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	TG	TG	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
22	induce	induce	PROPN	NNP	Number=Sing	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	X	LS	_	_	_	_	SpaceAfter=No
26	R	r	X	GW	_	_	_	_	_
27	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
30	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4970
# text = PMA- but not TG-induced IL-2R alpha is inhibited by the PKC inhibitor H7, whereas TG- but not PMA-induced IL-2R alpha was inhibited by cholera toxin, forskolin and 1,9-dideoxy forskolin.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	_
3	but	but	CCONJ	CC	_	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	TG-	TG-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
10	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	H7	H7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	TG	TG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
30	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
35	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	forskolin	forskolin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
41	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	dideoxy	dideoxy	NOUN	NN	Number=Sing	_	_	_	_
44	forskolin	forskolin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4971
# text = In toto, these results suggest that TG induces IL-2R alpha in human T cells through a PKC-independent pathway.
1	In	in	ADP	IN	_	_	_	_	_
2	toto	toto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	TG	TG	PRON	NN	Number=Sing	_	_	_	_
9	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	X	LS	_	_	_	_	SpaceAfter=No
13	R	r	X	GW	_	_	_	_	_
14	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
24	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4972
# text = Document 003001163 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001163	003001163	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4973
# text = Functions of glutathione and glutathione disulfide in immunology and immunopathology.
1	Functions	function	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
6	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	immunology	immunology	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	immunopathology	immunopathology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4974
# text = Even a moderate increase in the cellular cysteine supply elevates the intracellular glutathione (GSH) and glutathione disulfide (GSSG) levels and potentiates immunological functions of lymphocytes in vitro.
1	Even	even	ADV	RB	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
9	supply	supply	NOUN	NN	Number=Sing	_	_	_	_
10	elevates	elevate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
19	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	GSSG	GSSG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	potentiates	potentiate	NOUN	NNS	Number=Plur	_	_	_	_
26	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
27	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4975
# text = At low GSSG levels, T cells cannot optimally activate the immunologically important transcription factor NF kappa B, whereas high GSSG levels inhibit the DNA binding activity of NF kappa B.
1	At	at	ADP	IN	_	_	_	_	_
2	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
3	GSSG	GSSG	NOUN	NN	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
9	not	not	PART	RB	_	_	_	_	_
10	optimally	optimally	ADV	RB	_	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immunologically	immunologically	ADV	RB	_	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
23	GSSG	Gssg	NOUN	NN	Number=Sing	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4976
# text = The effects of GSSG are antagonized by reduced thioredoxin (TRX).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GSSG	GSSG	PRON	NN	Number=Sing	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	antagonized	antagonize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	thioredoxin	thioredoxin	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TRX	TRX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4977
# text = As the protein tyrosine kinase activities p56lck and p59fyn are activated in intact cells by hydrogen peroxide, they are likely targets for GSSG action.
1	As	as	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
7	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	lck	lck	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	p59fyn	p59fyn	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	hydrogen	hydrogen	NOUN	NN	Number=Sing	_	_	_	_
18	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
23	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	GSSG	GSSG	ADJ	JJ	Degree=Pos	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4978
# text = These redox-regulated enzymes trigger signal cascades for NF kappa B activation and transduce signals from the T cell antigen receptor, from CD4 and CD8 molecules, and from the IL-2 receptor beta-chain.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	redox	redox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
6	trigger	trigger	ADV	RBR	_	_	_	_	_
7	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
8	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	transduce	transduce	NOUN	NN	Number=Sing	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
21	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	_
28	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4979
# text = The effector phase of cytotoxic T cell responses and IL-2-dependent functions are inhibited even by a partial depletion of the intracellular GSH pool.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
3	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	T	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	even	even	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
22	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	GSH	Gsh	NOUN	NN	Number=Sing	_	_	_	_
27	pool	pool	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4980
# text = As signal transduction is facilitated by prooxidant conditions, we propose that the well-known immunological consequences of GSH depletion ultimately may be results of the accompanying GSSG deficiency.
1	As	as	ADP	IN	_	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	facilitated	facilitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	prooxidant	prooxidant	ADJ	JJ	Degree=Pos	_	_	_	_
8	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
18	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	GSH	Gsh	PROPN	NNP	Number=Sing	_	_	_	_
21	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
22	ultimately	ultimately	ADV	RB	_	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	results	result	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	accompanying	accompanying	PROPN	NNP	Number=Sing	_	_	_	_
29	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	_
30	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4981
# text = As HIV-infected patients and SIV-infected rhesus macaques have, on the average, significantly decreased plasma cyst(e)ine and intracellular GSH levels, we also hypothesize that AIDS may be the consequence of a GSSG deficiency as well.
1	As	as	ADP	IN	_	_	_	_	_
2	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	SIV-	SIV-	X	GW	_	_	_	_	SpaceAfter=No
7	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
8	rhesus	rhesus	NOUN	NN	Number=Sing	_	_	_	_
9	macaques	macaque	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	average	average	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
19	cyst	cyst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	e	e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	ine	ine	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	GSH	Gsh	NOUN	NN	Number=Sing	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	also	also	ADV	RB	_	_	_	_	_
31	hypothesize	hypothesize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
34	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	_
41	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
42	as	as	ADV	RB	_	_	_	_	_
43	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4982
# text = Document 003001170 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001170	003001170	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4983
# text = Interleukin 6-induced differentiation of a human B cell line into IgM-secreting plasma cells is mediated by c-fos.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	IgM	Igm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	secreting	secreting	ADJ	JJ	Degree=Pos	_	_	_	_
16	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4984
# text = The role of the protooncogene c-fos in interleukin (IL) 6-induced B cell differentiation was assessed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protooncogene	protooncogene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4985
# text = Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c-fos sense mRNA expression.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	SKW	SKW	PROPN	NNP	Number=Sing	_	_	_	_
4	6.4	6.4	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	_
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
19	sense	sense	NOUN	NN	Number=Sing	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4986
# text = The effect appeared within 30 min and returned to basal levels after 2 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	within	within	ADP	IN	_	_	_	_	_
5	30	30	NUM	CD	NumType=Card	_	_	_	_
6	min	min	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	returned	return	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4987
# text = The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p less than 0.001), whereas control oligonucleotides had no inhibitory effect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
5	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IgM	Igm	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	SKW	SKW	PROPN	NNP	Number=Sing	_	_	_	_
20	6.4	6.4	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	p	p	NOUN	NN	Number=Sing	_	_	_	_
24	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	whereas	whereas	SCONJ	IN	_	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
32	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
35	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4988
# text = These results indicate that activation of c-fos is involved in IL 6-induced differentiation of SKW 6.4 cells into IgM-secreting cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	_
14	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	SKW	SKW	PROPN	NNP	Number=Sing	_	_	_	_
20	6.4	6.4	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	into	into	ADP	IN	_	_	_	_	_
23	IgM	Igm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	secreting	secreting	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 4989
# text = Document 003001174 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001174	003001174	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 4990
# text = Dopamine stimulates expression of the human immunodeficiency virus type 1 via NF-kappaB in cells of the immune system.
1	Dopamine	Dopamine	PRON	PRP	_	_	_	_	_
2	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	via	via	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 4991
# text = Recent studies have reported that lymphocytes produce, transport and bind dopamine present in plasma.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	produce	produce	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	transport	transport	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
12	dopamine	dopamine	PRON	PRP	_	_	_	_	_
13	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4992
# text = However, the action of dopamine on HIV-1 gene expression in cells of the immune system has not yet been examined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	system	system	NOUN	NN	Number=Sing	_	_	_	_
19	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	yet	yet	ADV	RB	_	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4993
# text = Here, we have investigated the regulation of HIV-1 expression by dopamine in Jurkat T cells and in primary blood mononuclear cells (PBMC).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4994
# text = HIV-1 replication was increased by dopamine, which correlated with the increased levels of HIV-1 transactivation.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4995
# text = Our transient expression data revealed that dopamine stimulated transcription through the NF-kappaB element present in the long terminal repeat.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	dopamine	dopamine	PRON	PRP	_	_	_	_	_
8	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
20	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
21	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4996
# text = The importance of NF-kappaB sites was confirmed by using vectors containing wild-type or mutant kappaB sites in a heterologous promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4997
# text = Consistent with the role of NF-kappaB in mediating dopamine responsiveness, the proteasome inhibitor MG132 abolished dopamine-induced transcriptional activation.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	_
12	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	MG132	Mg132	PART	TO	Abbr=Yes	_	_	_	_
18	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4998
# text = We further explored the effect of dopamine in the presence of phorbol esters or tumor necrosis factor-alpha (TNF-alpha) known to activate NF-kappaB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	explored	explore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
16	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4999
# text = The combination of dopamine and TNF-alpha led to a stimulation of HIV-1 transcription and replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5000
# text = However, in contrast with TNF-alpha, dopamine treatment did not affect NF-kappaB DNA binding activity nor the concentrations of p50, p65 and IkappaB-alpha proteins, which suggests a distinct NF-kappaB activation mechanism.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	_
11	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	nor	nor	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	p65	p65	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5001
# text = These results reveal a new link between the dopamine system, cytokine signaling pathway and regulation of gene expression via the involvement of NF-kappaB in T cells and PBMC.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	link	link	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	dopamine	dopamine	NOUN	NN	Number=Sing	_	_	_	_
10	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	via	via	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	T	T	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5002
# text = Document 003001178 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001178	003001178	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5003
# text = Association of alterations in NF-kappa B moieties with HIV type 1 proviral latency in certain monocytic cells.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	moieties	moiety	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
15	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5004
# text = Human immunodeficiency virus type 1 (HIV-1) replication is controlled by a complex array of virally encoded and cellular proteins.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
17	array	array	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	virally	virally	ADV	RB	_	_	_	_	_
20	encoded	encod	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5005
# text = A wide spectrum of levels of HIV-1 expression have been demonstrated in various cells, both in cell culture and in vivo.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
3	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5006
# text = Molecular mechanisms leading to restricted HIV-1 replication may differ between certain cell types.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5007
# text = It is now demonstrated that HIV-1 proviral latency in the monocytic cell line U1, in which only extremely low levels of HIV-1 expression are detected in the baseline unstimulated state, is associated with alterations in nuclear factor-kappa B (NF-kappa B) moieties demonstrated in these cells by electrophoretic mobility shift assays (EMSAs) and in situ UV cross-linking studies.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
10	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	U1	U1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	extremely	extremely	ADV	RB	_	_	_	_	_
22	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	_
34	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
35	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
46	B	b	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
51	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	_
53	moieties	moiety	NOUN	NNS	Number=Plur	_	_	_	_
54	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
58	by	by	ADP	IN	_	_	_	_	_
59	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
60	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
61	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
62	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	in	in	ADP	IN	_	_	_	_	_
68	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
69	UV	UV	NOUN	NN	Number=Sing	_	_	_	_
70	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
71	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
72	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
73	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5008
# text = A predominance of p50 NF-kappa B moieties and possibly p50 homodimers or closely related species, rather than the p50-p56 heterodimer of NF-kappa B that is the predominant NF-kappa B species in most T lymphocytic and monocytic cells, is demonstrated in the nuclei of U1 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	predominance	predominance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	moieties	moiety	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	possibly	possibly	ADV	RB	_	_	_	_	_
12	p50	p50	NUM	CD	NumType=Card	_	_	_	_
13	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	closely	closely	ADV	RB	_	_	_	_	_
16	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
17	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	rather	rather	ADV	RB	_	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	p56	p56	NOUN	NN	Number=Sing	_	_	_	_
25	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
35	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	species	species	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
42	T	T	PROPN	NNP	Number=Sing	_	_	_	_
43	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5009
# text = This pattern of NF-kappa B-related moieties differs from the latently infected T lymphocytic cell line ACH-2, and from the U937 monocytic line, the parental cell line of the U1 cellular clone.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	moieties	moiety	NOUN	NNS	Number=Plur	_	_	_	_
10	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	latently	latently	ADV	RB	Degree=Pos	_	_	_	_
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	U937	U937	NUM	CD	NumType=Card	_	_	_	_
27	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
37	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
38	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5010
# text = As such, these data suggest that different proximal mechanisms may lead to restricted HIV-1 replication in various cell types.
1	As	as	ADP	IN	_	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5011
# text = Document 003001180 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001180	003001180	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5012
# text = Differential induction of DNA-binding activities following CD19 cross-linking in human B lineage cells.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	19	19	NUM	CD	NumType=Card	_	_	_	_
11	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5013
# text = The B cell-specific cell surface molecule CD19 is expressed at all stages of B cell development, including normal plasma cells, and mediates signal transduction via interaction with cytoplasmic effector proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B	B	NOUN	NN	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
9	CD19	CD19	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	all	all	DET	DT	_	_	_	_	_
14	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
28	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
29	via	via	ADP	IN	_	_	_	_	_
30	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
33	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5014
# text = Cross-linking CD19 on early human B lineage cells induces the formation of a CD19/Vav/phosphatidylinositol-3
1	Cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	CD19	Cd19	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	CD19/	Cd19/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	Vav/phosphatidylinositol	Vav/phosphatidylinositol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-3	-3	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 5015
# text = kinase complex, tyrosine phosphorylation of CD19 and Vav, and activation of the Ras pathway.
1	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
2	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD19	CD19	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5016
# text = To further explore the ramifications of CD19 signaling, the current study examined whether phosphorylation of Elk-1, activation of activator protein-1 (AP-1), or activation of nuclear factor-kappaB (NF-kappaB) transcription factors occurred following CD19 cross-linking.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ramifications	ramification	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	19	19	NUM	CD	NumType=Card	_	_	_	_
9	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
13	study	study	NOUN	NN	Number=Sing	_	_	_	_
14	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	whether	whether	SCONJ	IN	_	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Elk	elk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
46	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
48	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	19	19	NUM	CD	NumType=Card	_	_	_	_
50	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5017
# text = The cells used were the BLIN-1 pre-B cell line expressing low levels of cell surface mu heavy chain associated with surrogate light chain and the 1E8 immature B cell line expressing cell surface mu/kappa.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	BLIN	BLIN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
10	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
20	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
21	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
22	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	surrogate	surrogate	NOUN	NN	Number=Sing	_	_	_	_
25	light	light	NOUN	NN	Number=Sing	_	_	_	_
26	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	1E8	1E8	NUM	CD	NumType=Card	_	_	_	_
30	immature	immature	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	_
34	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
37	mu/	muith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5018
# text = Lysates from CD19 cross-linked 1E8 cells induced robust phosphorylation of an Elk-1 fusion protein in vitro, whereas no phosphorylation of Elk-1 fusion protein occurred using lysates from CD19 cross-linked BLIN-1 cells.
1	Lysates	Lysate	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	19	19	NUM	CD	NumType=Card	_	_	_	_
5	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-linked	-link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	1E8	1E8	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	robust	robust	ADJ	JJ	Degree=Pos	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	Elk	elk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	whereas	SCONJ	IN	_	_	_	_	_
23	no	no	DET	DT	_	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Elk	elk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
33	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	19	19	NUM	CD	NumType=Card	_	_	_	_
37	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	BLIN	Blin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5019
# text = An electrophoretic mobility shift assay employing AP-1 and NF-kappaB consensus oligonucleotides was used to demonstrate that AP-1 -binding activity increased, while constitutive NF-kappaB-binding activity was not enhanced, following 2 h of CD19 cross-linking in 1E8 cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	employing	employ	VERB	VBG	VerbForm=Ger	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
15	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
31	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	kappaB-	kappab-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	h	h	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	19	19	NUM	CD	NumType=Card	_	_	_	_
46	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	1E8	1E8	NUM	CD	NumType=Card	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5020
# text = Supershift experiments revealed that JunD and c-Fos proteins mediated anti-CD19 induced AP-1-binding activity in 1E8 cells.
1	Supershift	Supershift	PROPN	NNP	Number=Sing	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	anti-CD19	anti-CD19	NUM	CD	NumType=Card	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	1E8	1E8	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5021
# text = In contrast, CD19 cross-linking in BLIN-1 cells resulted in the induction of NF-kappaB, but had no apparent effect on AP-1-binding activity.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	19	19	NUM	CD	NumType=Card	_	_	_	_
6	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	BLIN	BLIN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	no	no	DET	DT	_	_	_	_	_
25	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5022
# text = These data suggest that CD19-mediated signal transduction activates different transcription factors at juxtaposed stages of B cell development that may culminate in the activation or suppression of distinct sets of genes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD19	CD19	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-mediated	-mediated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	juxtaposed	juxtapose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	culminate	culminate	VERB	VB	VerbForm=Inf	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
30	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5023
# text = Document 003001182 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001182	003001182	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5024
# text = [Regulation of transcription of the interleukin-2 gene in B-lymphocytes]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5025
# text = Since most B cell clones immortalized with EBV virus can be induced to produce interleukin-2, a typical T cell cytokine, we studied the role of different elements of the IL-2 promoter in such clones by transfection.
1	Since	since	ADP	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
6	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	EBV	EBV	NOUN	NN	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	t	NOUN	NN	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
40	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5026
# text = It was found, in particular, that the element TCEd, which binds the transcription factor NF-kB, is very active in all three B clones tested.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	very	very	ADV	RB	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	all	all	DET	DT	_	_	_	_	_
27	three	three	NUM	CD	NumType=Card	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
30	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5027
# text = This element has no activity in T cells of the Jurkat line.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5028
# text = The NFATd element, which binds the transcription factor NFAT-1 and is very active in T cells, is only weakly active in one B clone and not at all in another.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NFATd	Nfatd	PROPN	NNP	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	very	very	ADV	RB	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	only	only	ADV	RB	_	_	_	_	_
23	weakly	weakly	ADV	RB	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	one	one	NUM	CD	NumType=Card	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	at	at	ADV	RB	_	_	_	_	_
32	all	all	ADV	RB	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	another	another	DET	DT	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5029
# text = Different elements thus contribute to IL-2 promoter activity in different cells.
1	Different	different	ADJ	JJ	Degree=Pos	_	_	_	_
2	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5030
# text = Document 003001183 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001183	003001183	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5031
# text = Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo.
1	Altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
6	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
11	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
23	control	control	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5032
# text = The locus control region of the beta-globin cluster contains five DNase I hypersensitive sites (5'HS1-5) required for locus activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	locus	locus	ADJ	JJ	Degree=Pos	_	_	_	_
3	control	control	NOUN	NN	Number=Sing	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
11	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	five	five	NUM	CD	NumType=Card	_	_	_	_
13	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	hypersensitive	hypersensitive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'HS	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	locus	locus	ADJ	JJ	Degree=Pos	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5033
# text = 5'HS3 contains six G-rich motifs that are essential for its activity.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'HS3	'HS3	NUM	CD	NumType=Card	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	six	six	NUM	CD	NumType=Card	_	_	_	_
5	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
7	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5034
# text = Members of a protein family, characterized by three zinc fingers highly homologous to those found in transcription factor Sp1, interact with these motifs.
1	Members	member	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
11	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
12	highly	highly	ADV	RB	_	_	_	_	_
13	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5035
# text = Because point mutagenesis cannot distinguish between family members, it is not known which protein activates 5'HS3.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	point	point	NOUN	NN	Number=Sing	_	_	_	_
3	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
5	not	not	PART	RB	_	_	_	_	_
6	distinguish	distinguish	VERB	VB	VerbForm=Inf	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	which	which	DET	WDT	PronType=Int	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
20	HS3	HS3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5036
# text = We show that the function of such closely related proteins can be distinguished in vivo by matching point mutations in 5'HS3 with amino acid changes in the zinc fingers of Sp1 and EKLF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	closely	closely	ADV	RB	_	_	_	_	_
9	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	distinguished	distinguish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	matching	match	VERB	VBG	VerbForm=Ger	_	_	_	_
18	point	point	NOUN	NN	Number=Sing	_	_	_	_
19	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	's	PUNCT	``	_	_	_	_	SpaceAfter=No
23	HS3	HS3	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	amino	amino	DET	DT	_	_	_	_	_
26	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
27	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
31	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5037
# text = Testing their activity in transgenic mice shows that EKLF is a direct activator of 5'HS3.
1	Testing	testing	VERB	VBG	VerbForm=Ger	_	_	_	_
2	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
7	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'HS3	'HS3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5038
# text = Document 003001190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001190	003001190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5039
# text = Stimulation of the human immunodeficiency virus type 2 (HIV-2) gene expression by the cytomegalovirus and HIV-2 transactivator gene.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5040
# text = Human immunodeficiency virus (HIV) often causes latent infection.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	often	often	ADV	RB	_	_	_	_	_
8	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
10	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5041
# text = Transactivation by some DNA viruses has been implicated in inducing HIV-1 replication and pathogenesis.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	some	some	DET	DT	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5042
# text = The transactivator (IE-2) gene of the human cytomegalovirus (CMV) can enhance HIV-2 as well as HIV-1 gene expression in vitro.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IE	ie	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5043
# text = This inducer can act in concert with the HIV-2 tat gene and T-cell activation in enhancing gene expression in human CD4+ lymphocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
20	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5044
# text = While the HIV-2 and HIV-1 tat genes and T-cell activators apparently employ independent modes of action, the CMV transactivator in combination with the HIV-2 tat or T-cell activators may employ a gene activation pathway with some common and some distinct components.
1	While	while	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
16	apparently	apparently	ADV	RB	_	_	_	_	_
17	employ	employ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	modes	mode	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	CMV	Cmv	PROPN	NNP	Number=Sing	_	_	_	_
25	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	employ	employ	VERB	VB	VerbForm=Inf	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	some	some	DET	DT	_	_	_	_	_
46	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	some	some	DET	DT	_	_	_	_	_
49	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
50	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5045
# text = Both HIV-2 and CMV transactivators enhance HIV-2 gene expression by transcriptional activation involving transcript initiation as well as elongation, with CMV transactivator affecting elongation more than the initiation.
1	Both	both	DET	DT	_	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	CMV	Cmv	NOUN	NN	Number=Sing	_	_	_	_
7	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
8	enhance	enhance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
18	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
19	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
20	as	as	ADV	RB	_	_	_	_	_
21	well	well	ADV	RB	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	CMV	Cmv	NOUN	NN	Number=Sing	_	_	_	_
27	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
28	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
29	elongation	elongation	NOUN	NN	Number=Sing|Typo=Yes	_	_	_	_
30	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
31	than	than	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5046
# text = A significant proportion of transcripts appear to terminate prematurely in the absence of transactivators.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	terminate	terminate	VERB	VB	VerbForm=Inf	_	_	_	_
9	prematurely	prematurely	ADV	RB	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5047
# text = Deletion mutation analysis of the HIV-2 long terminal repeat (LTR) suggests that the element that responds to CMV transactivation in human CD4+ lymphocytes is either a diffuse one or located downstream of the HIV-2 enhancer element.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	responds	respond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
23	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	+	+	SYM	SYM	_	_	_	_	_
28	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	either	either	CCONJ	CC	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	diffuse	diffuse	NOUN	NN	Number=Sing	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
43	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5048
# text = Document 003001192 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001192	003001192	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5049
# text = Tissue-specific expression of the platelet GPIIb gene.
1	Tissue	Tissue	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
8	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5050
# text = One of the major objectives in the study of thrombogenesis is to determine the mechanisms by which a hematopoietic progenitor is activated and committed to the megakaryocytic lineage.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	objectives	objective	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	study	study	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	thrombogenesis	thrombogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
11	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	which	which	DET	WDT	PronType=Int	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	committed	committed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5051
# text = Recent development of primary cultures of human megakaryocytes and the molecular cloning of genes that are specific to this lineage offer the possibility of getting some insights into the genetic mechanisms that control megakaryocytopoiesis.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
12	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
21	offer	offer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	SCONJ	IN	_	_	_	_	_
25	getting	get	VERB	VBG	VerbForm=Ger	_	_	_	_
26	some	some	DET	DT	_	_	_	_	_
27	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
28	into	into	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
31	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	megakaryocytopoiesis	megakaryocytopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5052
# text = One gene of interest is the glycoprotein IIb (GPIIb) gene; GPIIb, the alpha subunit of the platelet cytoadhesin GPIIb-IIIa, is produced in megakaryocytes at an early stage of the differentiation, whereas the other subunit of this complex, GPIIIa, is expressed in other cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interest	interest	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
8	IIb	IIb	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
22	cytoadhesin	cytoadhesin	ADP	IN	_	_	_	_	_
23	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	IIIa	IIIa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
34	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	whereas	whereas	SCONJ	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
42	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
45	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	GPIIIa	GPIIIa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5053
# text = For these reasons, the 5'-flanking region of the GPIIb gene was used to identify the regions that interact with DNA-binding nuclear factors.
1	For	for	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	reasons	reason	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5054
# text = A fragment extending from -643 to +33 is capable of controlling the tissue-specific expression of the CAT gene in transfection experiments.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
3	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	643	643	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	+33	+33	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	SCONJ	IN	_	_	_	_	_
12	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
24	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5055
# text = Within this region, we have identified several sequences that are implicated in DNA protein interactions as shown in DNAse I footprints and gel mobility shift assays.
1	Within	within	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	DNAse	DNAse	NOUN	NN	Number=Sing	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5056
# text = One region, centered at -54, is similar to a nuclear factor E1-binding site, and a region located at position -233 contains a CCAAT motif.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	54	54	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	E1	e1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	position	position	NOUN	NN	Number=Sing	_	_	_	_
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	233	233	NUM	CD	NumType=Card	_	_	_	_
28	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
31	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5057
# text = Two domains centered at positions -345 and -540, respectively, bind proteins that are present in megakaryocytic cells and nonrelated cells as well.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
3	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	345	345	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	540	540	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	bind	bind	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	nonrelated	nonrelate	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	as	as	ADV	RB	_	_	_	_	_
26	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5058
# text = Finally, two other domains, located at positions -460 and -510, interact with proteins that are only present in megakaryocytic cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	460	460	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	510	510	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5059
# text = In addition, deletion of the region containing these two domains results in a significant decrease of the promoter activity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
12	results	result	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
16	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5060
# text = It is very likely that these domains bind megakaryocyte-specific nuclear proteins acting as positive transcription factors.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	very	very	ADV	RB	_	_	_	_	_
4	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
8	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	megakaryocyte	megakaryocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5061
# text = Document 003001196 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001196	003001196	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5062
# text = HIV-1
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 5063
# text = Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells.
1	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5064
# text = The human immunodeficiency virus type 1 long terminal repeat, HIV-1-LTR, contains binding sites for several cellular transcription factors which contribute to HIV-1 gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5065
# text = Our previous studies on the function of the HIV-1-encoded Nef protein suggested that Nef may be an inhibitor HIV-1 transcription.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
15	protein	protein	PROPN	NNP	Number=Sing	_	_	_	_
16	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	inhibitor	inhibitor	ADJ	JJ	Degree=Pos	_	_	_	_
23	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5066
# text = To determine whether Nef affects the binding of cellular factors implicated in HIV-1 regulation, 32P-labeled oligonucleotides corresponding to the binding sites were incubated with nuclear extracts prepared from Nef-expressing T-cell lines that were not stimulated or were stimulated with T-cell mitogens.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
5	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	32P	32p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
22	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
32	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	expressing	expresse	ADJ	JJ	Degree=Pos	_	_	_	_
37	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
40	that	that	PRON	WDT	PronType=Rel	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	not	not	PART	RB	_	_	_	_	_
43	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	with	with	ADP	IN	_	_	_	_	_
48	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5067
# text = We found that Nef inhibited the recruitment of AP-1 DNA-binding activity in mitogen-stimulated human T-cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5068
# text = Additionally,
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 5069
# text = Nef expressing cells were transiently transfected with a plasmid in which HIV-1 AP-1 DNA recognition sequences were cloned downstream of the chloramphenicol acetyltransferase (CAT) gene.
1	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
2	expressing	expressing	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	transiently	transiently	ADV	RB	_	_	_	_	_
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
20	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
27	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5070
# text = Mitogen-mediated transcriptional activation of the CAT gene in this construct was inhibited in Nef-expressing cells but not in control cells.
1	Mitogen	Mitogen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	control	control	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5071
# text = These studies suggest that, by inhibiting AP-1 activation, Nef may play a role in regulating HIV-1 gene expression in infected T-cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	inhibiting	inhibiting	VERB	VBG	VerbForm=Ger	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5072
# text = Document 003001200 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001200	003001200	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5073
# text = Cyclosporin
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5074
# text = A inhibits early mRNA expression of G0/G1 switch gene 2 (G0S2) in cultured human blood mononuclear cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	G0/G1	G0/G1	NUM	CD	NumType=Card	_	_	_	_
8	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	G0S2	G0s2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5075
# text = Cyclosporin A (CsA) may achieve its immunosuppressive effects by inhibiting the calcium- and calmodulin-dependent phosphatase calcineurin which is required for activation of target genes by members of the NFAT (nuclear factor of activated T cells) transcription factor family.
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
2	A	A	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	achieve	achieve	VERB	VB	VerbForm=Inf	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	calmodulin	calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
21	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	target	target	NOUN	NN	Number=Sing	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5076
# text = Among these target genes is the gene encoding interleukin-2 (IL2), a cytokine facilitating progression through the G1 phase of the cell cycle.
1	Among	among	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	target	target	NOUN	NN	Number=Sing	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL2	IL2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	facilitating	facilitate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	G1	G1	PROPN	NNP	Number=Sing	_	_	_	_
23	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5077
# text = However, IL2 does not reverse CsA inhibition, suggesting that at least one other NFAT-sensitive gene may be involved.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL2	IL2	NUM	CD	NumType=Card	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	reverse	reverse	VERB	VB	VerbForm=Inf	_	_	_	_
7	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5078
# text = The human G0/G1 switch gene, G0S2, has potential NFAT-binding sites in the 5' flank and encodes a small basic potential phosphoprotein of unknown function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	G0/G1	G0/g1	NOUN	NN	Number=Sing	_	_	_	_
4	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	G0S2	G0s2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
11	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	'	's	PUNCT	''	_	_	_	_	_
19	flank	flank	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
24	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
25	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
26	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
29	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5079
# text = Using a sensitive, reverse transcription-polymerase chain reaction (RT-PCR) assay, G0S2 mRNA levels were assayed in cultured blood mononuclear cells.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	reverse	reverse	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	RT-PCR	RT-PCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	G0S2	G0S2	NUM	CD	NumType=Card	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
24	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5080
# text = Freshly isolated cells contain high levels of G0S2 mRNA which rapidly decline.
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	G0S2	G0s2	NUM	CD	NumType=Card	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	rapidly	rapidly	ADV	RB	_	_	_	_	_
12	decline	decline	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5081
# text = This "spontaneous stimulation" is also noted with some other G0S genes and has been attributed to some aspect of the isolation procedure.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
3	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
4	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	"	"	PUNCT	''	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	some	some	DET	DT	_	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	G0S	g0s	NOUN	NNS	Number=Plur	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	_
20	aspect	aspect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
24	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5082
# text = In cells that have been preincubated to lower mRNA levels, there is a transient increase in G0S2 mRNA, peaking between 1-2 h, in response to Concanavalin-A (ConA), or to the combination of phorbol ester (TPA), and the calcium ionophore, ionomycin.
1	In	in	ADP	IN	_	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	lower	lower	VERB	VB	VerbForm=Inf	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	there	there	PRON	EX	_	_	_	_	_
13	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	G0S2	G0S2	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	Concanavalin	Concanavalin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	A	A	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	ConA	ConA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
44	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
52	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5083
# text = Both these responses are inhibited by CsA.
1	Both	both	DET	DT	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5084
# text = Our results suggest that G0S2 expression is required to commit cells to enter the G1 phase of the cell cycle, and that, while not excluding other possible targets, early inhibition of G0S2 expression by CsA may be important in achieving immunosuppression.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	G0S2	G0s2	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	commit	commit	VERB	VB	VerbForm=Inf	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	enter	enter	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	G1	G1	PROPN	NNP	Number=Sing	_	_	_	_
16	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	while	while	SCONJ	IN	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	excluding	exclude	VERB	VBG	VerbForm=Ger	_	_	_	_
28	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
29	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
30	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
33	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	G0S2	G0S2	NUM	CD	NumType=Card	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
42	in	in	SCONJ	IN	_	_	_	_	_
43	achieving	achieve	VERB	VBG	VerbForm=Ger	_	_	_	_
44	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5085
# text = G0S2 may be of value as a reporter gene for analyzing the mechanism of action of CsA and its influence on the positive and negative selection of lymphocytes in response to self and not-self antigens.
1	G0S2	G0s2	NOUN	NN	Number=Sing	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	value	value	NOUN	NN	Number=Sing	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	SCONJ	IN	_	_	_	_	_
11	analyzing	analyze	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	action	action	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
26	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	self	self	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	self	self	NOUN	NN	Number=Sing	_	_	_	_
37	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5086
# text = Document 003001202 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001202	003001202	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5087
# text = ETS1, NFkappaB and AP1 synergistically transactivate the human GM-CSF promoter.
1	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	_
6	synergistically	synergistically	ADV	RB	_	_	_	_	_
7	transactivate	transactivate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5088
# text = Activation of helper T cells results in coordinate expression of a number of cytokines involved in differentiation, proliferation and activation of the haematopoietic system.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	number	number	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	haematopoietic	haematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5089
# text = Granulocyte-macrophage colony stimulating factor (GM-CSF) is one such cytokine, whose increased expression results mostly from increases in transcription.
1	Granulocyte	Granulocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
5	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	mostly	mostly	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5090
# text = Cis-acting elements with NFkappaB, AP1 and ETS-like binding motifs have been identified in the promoter region of the GM-CSF gene, and are important or essential for transcriptional activity following T cell activation.
1	Cis	Cis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	ETS	Ets	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	like	like	SCONJ	IN	_	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
37	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5091
# text = ETS1 is a transcription factor of the ETS family that is expressed in T cells.
1	ETS1	Ets1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5092
# text = We have previously shown that ETS1 can transactivate GM-CSF in Jurkat T cells, but only after the cells have been stimulated by treatment with PMA and ionomycin, agents that mimic T cell activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	only	only	ADV	RB	_	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5093
# text = Thus we proposed that ETS1, which is expressed constitutively in Jurkat cells, may act in concert with PMA/ionomycin inducible factors.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	proposed	propose	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	ADP	IN	Typo=Yes	_	_	_	_
5	ETS1	Ets1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	constitutively	constitutively	ADV	RB	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	ionomycin	ionomycin	ADP	IN	_	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5094
# text = Here we show that ETS1 can transactivate a GM-CSF reporter construct in unstimulated Jurkat cells, providing that either NFkappaB or AP1 transcription factors are supplied by co-transfection.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	either	either	CCONJ	CC	_	_	_	_	_
22	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	supplied	supply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5095
# text = We confirm that binding of endogenous NFkappaB and AP1 is induced following PMA/ionomycin treatment of T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	confirm	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5096
# text = Transactivation by ETS1, NFkappaB and AP1 is synergistic, and mutation of the individual binding sites reveals that the transcriptional activities of these factors are interdependent.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	individual	individual	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	interdependent	interdependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5097
# text = Our results suggest that constitutive ETS1, and inducible NFkappaB and AP1, cooperate as part of a higher order transcriptional complex in activated T cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	ETS1	Ets1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP1	Ap1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	cooperate	cooperate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	part	part	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
20	order	order	NOUN	NN	Number=Sing	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5098
# text = Document 003001205 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001205	003001205	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5099
# text = Synergism between two distinct elements of the HTLV-I enhancer during activation by the trans-activator of HTLV-I.
1	Synergism	Synergism	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5100
# text = We have conducted functional studies of the enhancer elements of human T-cell leukemia virus type I (HTLV-I) using the human T-cell lines Jurkat and MOLT 4, which are negative for HTLV-I, and MT-2 and TL-Mor, which carry the proviral genome of HTLV-I.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	MOLT	MOLT	PROPN	NNP	Number=Sing	_	_	_	_
32	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	MT	Mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	TL	Tl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	Mor	Mor	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	which	which	PRON	WDT	PronType=Rel	_	_	_	_
52	carry	carry	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
55	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	I	I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5101
# text = Two distinct elements have been implicated in function of the HTLV-I enhancer.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	function	function	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5102
# text = One is the 21-base-pair (bp) core element that is responsible for trans-activation by the HTLV-I trans-activator p40tax and that has the ability to bind to cyclic-AMP responsive element binding factor (CREB)-like factor(s).
1	One	one	PRON	PRP	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	core	core	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	-activation	-activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
28	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
40	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
41	element	element	NOUN	NN	Number=Sing	_	_	_	_
42	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	like	like	ADP	IN	_	_	_	_	_
49	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	s	s	X	AFX	_	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5103
# text = The other is a region interposed between the 21-bp elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	interposed	interpose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5104
# text = In this study we demonstrate that a subfragment (C26) in the region between the 21-bp elements is involved in trans-activation by p40tax, possibly through binding to an NF-kappa B-like nuclear factor or factors.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	subfragment	subfragment	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	C26	c26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-activation	-activation	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	possibly	possibly	ADV	RB	_	_	_	_	_
30	through	through	SCONJ	IN	_	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	like	like	ADP	IN	_	_	_	_	_
40	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5105
# text = Formation of the protein-DNA complex with the C26 subfragment was positively affected by p40tax.
1	Formation	Formation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	C26	c26	NOUN	NN	Number=Sing	_	_	_	_
11	subfragment	subfragment	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	positively	positively	ADV	RB	_	_	_	_	_
14	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5106
# text = The C26 element conferred partial responsiveness to p40tax when linked to one copy of the 21-bp element that, by itself, showed little activation in response to p40tax.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	C26	c26	PROPN	NNP	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
6	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	p40tax	p40tax	VERB	VB	VerbForm=Inf	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5107
# text = However, the C26 element alone, even when repeated, could not be activated by p40tax, unlike other NF-kappa B-binding elements.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	C26	c26	PROPN	NNP	Number=Sing	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	even	even	ADV	RB	_	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	repeated	repeate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	unlike	unlike	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5108
# text = In contrast, the C26 element itself was profoundly activated upon stimulation with 12-O-tetradecanoylphorbol-13-acetate.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	C26	c26	PROPN	NNP	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	profoundly	profoundly	ADV	RB	_	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5109
# text = These findings therefore suggest that the HTLV-I enhancer contains multiple functional elements, including binding sites for at least CREB- and NF-kappa B-like factors, which synergistically cooperate in activation of the HTLV-I enhancer in response to p40tax.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	at	at	ADV	RB	_	_	_	_	_
21	least	least	ADV	RBS	Degree=Sup	_	_	_	_
22	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	like	like	ADP	IN	_	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	synergistically	synergistically	ADV	RB	_	_	_	_	_
35	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
43	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	response	response	NOUN	NN	Number=Sing	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	p40tax	p40tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5110
# text = Our results also demonstrate that TPA-dependent activation of the HTLV-I enhancer may be mediated through the C26 element.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	C26	c26	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5111
# text = Document 003001208 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001208	003001208	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5112
# text = Regulation of sialoadhesin expression on rat macrophages.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	sialoadhesin	sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5113
# text = Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5114
# text = Sialoadhesin is a macrophage-restricted member of the Ig superfamily that mediates adhesion with lymphoid and myeloid cells.
1	Sialoadhesin	Sialoadhesin	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	member	member	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
11	superfamily	superfamily	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5115
# text = It is expressed on a subpopulation of macrophages in lymphoid tissues and in chronic inflammation (e.g., during autoimmune diseases).
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	subpopulation	subpopulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
21	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5116
# text = We have studied the regulation of sialoadhesin expression in vitro and show that glucocorticoids (GC) induce sialoadhesin expression on freshly isolated rat macrophages and the rat macrophage cell line R2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	sialoadhesin	sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
19	sialoadhesin	sialoadhesin	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	freshly	freshly	ADV	RB	_	_	_	_	_
23	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
25	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
29	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	R2	r2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5117
# text = The cytokines IFN-beta, IFN-gamma, IL-4, and LPS, although unable to induce sialoadhesin expression by themselves, were able to enhance GC-mediated induction of sialoadhesin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	sialoadhesin	sialoadhesin	ADP	IN	_	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	themselves	themself	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
31	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	sialoadhesin	sialoadhesin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5118
# text = Sialoadhesin expression was functional as shown by cell adhesion assays with human RBCs.
1	Sialoadhesin	Sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	RBCs	RBC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5119
# text = Northern blotting experiments indicated that regulation predominantly occurred at the mRNA level.
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	predominantly	predominantly	ADV	RB	_	_	_	_	_
8	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5120
# text = Comparison of the different combinations of GC and cytokines/LPS revealed differences in the level of GC-dependent enhancement of sialoadhesin expression, with IFN-beta and IL-4 being more potent than IFN-gamma and LPS.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
12	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	sialoadhesin	sialoadhesin	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
35	more	more	ADV	RBR	_	_	_	_	_
36	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
37	than	than	ADP	IN	_	_	_	_	_
38	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5121
# text = Moreover, the effects of IFN-gamma and LPS could be reproduced by priming, whereas IFN-beta and IL-4 were required simultaneously with GC.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	reproduced	reproduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	priming	priming	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5122
# text = The regulation of sialoadhesin expression was mediated by the GC receptor, and not by mineralocorticoid receptor, as shown by inhibition experiments with specific antagonists.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	sialoadhesin	sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	mineralocorticoid	mineralocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5123
# text = Finally, it is demonstrated that macrophages in the adrenal gland, the major site of endogenous GC production, express sialoadhesin.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
11	gland	gland	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
18	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
22	sialoadhesin	sialoadhesin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5124
# text = This study demonstrates that GC act as a primary inducer of sialoadhesin expression on rat macrophages, and that the response can be enhanced by IFN-beta, T cell-derived cytokines, or LPS.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	_
6	act	act	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	sialoadhesin	sialoadhesin	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5125
# text = Document 003001209 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001209	003001209	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5126
# text = Transcription factor activation in lymphokine activated killer cells and lymphocytes from patients receiving IL-2 immunotherapy.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	receiving	receive	VERB	VBG	VerbForm=Ger	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	immunotherapy	immunotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5127
# text = Administration of the cytokine interleukin-2 (IL-2) can result in therapeutic benefits for individuals with renal cell carcinoma and melanoma.
1	Administration	Administration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
17	benefits	benefit	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	melanoma	melanoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5128
# text = Here we report an analysis of the transcription factor families AP-1, Sp1, NF-kappaB, and signal transducers and activators of transcription (STAT) in cancer patients' lymphocytes before and after IL-2 immunotherapy, as assessed by a gel-shift assay.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	families	family	NOUN	NNS	Number=Plur	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Sp1	Sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
23	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
33	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	'	's	PUNCT	''	_	_	_	_	_
35	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	before	before	ADP	IN	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	after	after	ADP	IN	_	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	immunotherapy	immunotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	as	as	SCONJ	IN	_	_	_	_	_
45	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
51	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5129
# text = An in vitro surrogate of IL-2 immunotherapy is the incubation of fresh peripheral blood mononuclear cells (PBMC) from healthy individuals in IL-2 for several days, resulting in the production of lymphokine-activated killer (LAK) activity in these cultures.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
4	surrogate	surrogate	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	immunotherapy	immunotherapy	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
31	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	LAK	LAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
48	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5130
# text = One purpose of this study was to describe the profile of transcription factor activation in these different populations, and assess whether the patterns observed correlated with functional differences in these cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	describe	describe	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	assess	assess	NOUN	NN	Number=Sing	_	_	_	_
22	whether	whether	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
25	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
29	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5131
# text = Prior to in vivo IL-2 administration, the typical binding pattern of transcription factors in PBMC from patients resembled that seen in fresh PBMC from healthy individuals.
1	Prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	administration	administration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
21	resembled	resemble	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
26	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
29	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5132
# text = Over a 3-week course of IL-2 therapy, in most patients the binding patterns of AP-1 , Sp1, and NF-kappaB proteins changed to resemble those seen in PBMC activated by IL-2 in vitro.
1	Over	over	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	week	week	NOUN	NN	Number=Sing	_	_	_	_
6	course	course	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	,	,	PUNCT	,	_	_	_	_	_
24	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	changed	chang	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	resemble	resemble	VERB	VB	VerbForm=Inf	_	_	_	_
34	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
35	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5133
# text = However, the cells obtained from IL-2-treated patients did not have low-level constitutive expression of STAT binding factors as did LAK cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	STAT	Stat	SCONJ	IN	_	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	LAK	LAK	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5134
# text = When these patient cells were further stimulated by IL-2 in vitro, additional differences in STAT induction patterns were noted.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	further	further	ADV	RB	_	_	_	_	_
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
16	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5135
# text = These data provide further information on the molecular events occurring in immune cells generated through in vivo and in vitro administration of IL-2, and further document that there is not a precise congruence between PBMC activated in vivo and in vitro by IL-2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
5	information	information	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
21	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
29	document	document	NOUN	NN	Number=Sing	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	there	there	PRON	EX	_	_	_	_	_
32	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
36	congruence	congruence	NOUN	NN	Number=Sing	_	_	_	_
37	between	between	ADP	IN	_	_	_	_	_
38	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
39	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5136
# text = Document 003001214 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001214	003001214	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5137
# text = Positive and negative regulation of immunoglobulin gene expression by a novel B-cell-specific enhancer element.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5138
# text = A new B-cell-specific enhancer element has been identified 3' of E4 and the octamerlike motifs in the human immunoglobulin heavy-chain gene enhancer.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
3	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	cell-specific	cell-specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	E4	E4	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	octamerlike	octamerlike	ADJ	JJ	Degree=Pos	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
22	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5139
# text = Tandem copies of this 67-bp MnlI-AluI fragment, when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter, stimulated transcription in B cells but not in Jurkat T cells or HeLa cells.
1	Tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
2	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	67	67	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
8	MnlI	MnlI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AluI	AluI	PROPN	NNP	Number=Sing	_	_	_	_
11	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	when	when	ADV	WRB	PronType=Int	_	_	_	_
14	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
18	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	conalbumin	conalbumin	NOUN	NN	Number=Sing	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
35	T	T	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5140
# text = Footprinting analysis revealed that the identical sequence CCGAAACTGAAAAGG, designated E6, was protected by nuclear extracts from B cells, T cells, or HeLa cells.
1	Footprinting	Footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
2	analysis	analysis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	CCGAAACTGAAAAGG	Ccgaaactgaaaagg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	designated	designate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	E6	e6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5141
# text = Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
8	E6	e6	PROPN	NNP	Number=Sing	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
22	band	band	NOUN	NN	Number=Sing	_	_	_	_
23	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5142
# text = In agreement with the results of gel retardation assays, tandem copies of the E6 motif stimulated transcription in ARH77 and Raji cells but not in Jurkat or HeLa cells.
1	In	in	ADP	IN	_	_	_	_	_
2	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
8	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
9	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
12	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	E6	e6	PROPN	NNP	Number=Sing	_	_	_	_
16	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
17	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	ARH77	ARH77	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5143
# text = Furthermore, a mutant E6 motif lost both in vitro binding activity and in vivo enhancer activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
5	E6	e6	PROPN	NNP	Number=Sing	_	_	_	_
6	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
7	lost	lose	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5144
# text = In striking contrast to the mouse
1	In	in	ADP	IN	_	_	_	_	_
2	striking	strik	ADJ	JJ	Degree=Pos	_	_	_	_
3	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5145
# text = Ig heavy-chain enhancer, in which the octamer motif acts as a B-cell-specific enhancer element, the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
11	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
12	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
25	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	octamerlike	octamerlike	ADJ	JJ	Degree=Pos	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	one	one	NUM	CD	NumType=Card	_	_	_	_
31	base	base	NOUN	NN	Number=Sing	_	_	_	_
32	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	only	only	ADV	RB	_	_	_	_	_
41	very	very	ADV	RB	_	_	_	_	_
42	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
43	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	no	no	DET	DT	_	_	_	_	_
47	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
48	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
51	own	own	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5146
# text = Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both Jurkat and HeLa cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	MnlI	MnlI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	AluI	AluI	PROPN	NNP	Number=Sing	_	_	_	_
7	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	conalbumin	conalbumin	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5147
# text = Moreover, simian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in HeLa cells but not in B cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	40	40	NUM	CD	NumType=Card	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	MnlI	MnlI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AluI	AluI	PROPN	NNP	Number=Sing	_	_	_	_
15	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5148
# text = Thus, the novel enhancer element identified in this study is probably a target site for both positive and negative factors.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	study	study	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	probably	probably	ADV	RB	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	target	target	NOUN	NN	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5149
# text = Document 003001215 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001215	003001215	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5150
# text = A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
5	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	exclusively	exclusively	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	myelo	myelo	X	AFX	_	_	_	_	SpaceAfter=No
10	-monocytic	-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	processes	process	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
21	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	impair	impair	VERB	VB	VerbForm=Inf	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
29	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5151
# text = Two groups of U937 promonocytic cells were obtained by limiting dilution cloning which differed strikingly in their ability to support human immunodeficiency virus 1 (HIV-1) replication.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	limiting	limite	VERB	VBG	VerbForm=Ger	_	_	_	_
11	dilution	dilution	NOUN	NN	Number=Sing	_	_	_	_
12	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	strikingly	strikingly	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	support	support	VERB	VB	VerbForm=Inf	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5152
# text = "Plus" clones replicated the virus efficiently, whereas "minus" clones did not.
1	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
2	Plus	plus	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	"	"	PUNCT	''	_	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	replicated	replicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	efficiently	efficiently	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	whereas	whereas	SCONJ	IN	_	_	_	_	_
11	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
12	minus	minus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	"	"	PUNCT	''	_	_	_	_	_
14	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
15	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5153
# text = We examined these clones for differences in nuclear factor (NF)-kappa B activity which might account for the observed phenomenon.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
19	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
23	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5154
# text = Stimulation of plus clones liberated the classical p50-p65 complex from cytoplasmic pools, whereas minus clones produced an apparently novel, faster-migrating complex, as judged by electrophoretic mobility shift assays.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	plus	plus	CCONJ	CC	_	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	liberated	liberate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
8	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	pools	pool	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	wherea	SCONJ	IN	_	_	_	_	_
17	minus	minus	ADJ	JJ	Degree=Pos	_	_	_	_
18	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
19	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	apparently	apparently	ADV	RB	_	_	_	_	_
22	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	faster	faster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
33	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
34	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
35	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5155
# text = It is surprising that the faster-migrating complex was composed also of p50 and p65.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	surprising	surprising	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	faster	faster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5156
# text = However, the p65 subunit was COOH-terminally truncated, as shown by immunoprecipitation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
5	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	COOH	COOH	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	terminally	terminally	ADV	RB	_	_	_	_	_
10	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5157
# text = The truncation resulted from limited proteolysis of p65 during cellular extraction which released particular lysosomal serine proteases, such as elastase, cathepsin G, and proteinase 3.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
3	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
6	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p65	p65	NUM	CD	NumType=Card	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	extraction	extraction	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	released	release	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
15	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
17	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	cathepsin	cathepsin	NOUN	NN	Number=Sing	_	_	_	_
24	G	G	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	proteinase	proteinase	NOUN	NN	Number=Sing	_	_	_	_
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5158
# text = These specific proteases are coordinately expressed and were present exclusively in the minus U937 clones, but not in the plus clones, as demonstrated in the case of cathepsin G.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	coordinately	coordinately	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
10	exclusively	exclusively	ADV	RB	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	minus	minus	ADJ	JJ	Degree=Pos	_	_	_	_
14	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
15	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	plus	plus	ADJ	JJ	Degree=Pos	_	_	_	_
22	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	case	case	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cathepsin	cathepsin	NOUN	NN	Number=Sing	_	_	_	_
31	G	G	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5159
# text = In addition, these proteases were detected in certain subclones of THP-1 and HL-60 cells and in primary monocytes, in each case correlating with the truncated from of p65.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
10	subclones	subclone	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	60	60	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	each	each	DET	DT	_	_	_	_	_
27	case	case	NOUN	NN	Number=Sing	_	_	_	_
28	correlating	correlat	VERB	VBG	VerbForm=Ger	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5160
# text = We demonstrate in vitro cleavage of p65 by purified elastase and cathepsin G.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p65	p65	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	cathepsin	cathepsin	NOUN	NN	Number=Sing	_	_	_	_
13	G	g	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5161
# text = It is possible that particular serine proteases may have inhibiting effects on the replication of HIV-1 in myelo-monocytic cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
6	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
7	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
10	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	myelo	myelo	X	AFX	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5162
# text = The data also demonstrate that special precautions must be taken when making extracts from myelo-monocytic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	special	special	ADJ	JJ	Degree=Pos	_	_	_	_
7	precautions	precaution	NOUN	NNS	Number=Plur	_	_	_	_
8	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	taken	take	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	when	when	ADV	WRB	PronType=Int	_	_	_	_
12	making	make	VERB	VBG	VerbForm=Ger	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	myelo	myelo	X	AFX	_	_	_	_	SpaceAfter=No
16	-monocytic	-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5163
# text = Document 003001217 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001217	003001217	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5164
# text = Nuclear factor-kappaB activation in human monocytes stimulated with lipopolysaccharide is inhibited by fibroblast conditioned medium and exogenous PGE2.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	fibroblast	fibroblast	ADV	RB	_	_	_	_	_
15	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	medium	medium	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
19	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5165
# text = The nuclear factor kappaB (NF-kappaB) is thought to be crucially involved in the gene activation of several cytokines, including tumor necrosis factor alpha (TNF).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	crucially	crucially	ADV	RB	_	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5166
# text = Previously, we showed that fibroblast conditioned medium (FCM) is able to inhibit both TNF mRNA accumulation and protein release in peripheral blood-derived human monocytes (PBM) stimulated with lipopolysaccharide (LPS).
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	fibroblast	fibroblast	ADV	RB	_	_	_	_	_
7	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FCM	FCM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
18	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
19	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	release	release	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PBM	PBM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5167
# text = In this study we have investigated the effect of FCM on the LPS-induced DNA-binding activity of NF-kappaB, by means of electrophoretic shift assay (EMSA).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FCM	FCM	PROPN	NNP	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	means	means	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
29	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
30	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5168
# text = We provide evidence that FCM strongly inhibits the LPS-induced NF-kappaB activation in PBM.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	FCM	FCM	PROPN	NNP	Number=Sing	_	_	_	_
6	strongly	strongly	ADV	RB	_	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	PBM	PBM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5169
# text = Furthermore, we show that exogenous PGE2 mimics the NF-kappaB inhibitory effect of FCM.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	PGE2	PGE2	NOUN	NN	Number=Sing	_	_	_	_
8	mimics	mimics	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	FCM	FCM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5170
# text = On the other hand, FCM produced in the presence of indomethacin does not inhibit NF-kappaB activation by LPS.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	FCM	FCm	PROPN	NNP	Number=Sing	_	_	_	_
7	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	indomethacin	indomethacin	NOUN	NN	Number=Sing	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5171
# text = Our results lend further support to the hypothesis that inflammatory and immune responses of monocytes/macrophages may be modulated at the molecular level by signals originating from tissue structural cells such as fibroblasts.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	lend	lend	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
5	support	support	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
27	originating	originate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
30	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5172
# text = Document 003001224 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001224	003001224	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5173
# text = Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity.
1	Mitogen	Mitogen	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
7	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5174
# text = We have analysed the effect of mitogenic lectins on c-Fos and c-Jun protein levels as well as on activator protein-1 (AP-1) binding and enhancer activity in Jurkat T-cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
8	lectins	lectin	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADV	RB	_	_	_	_	_
20	well	well	ADV	RB	Degree=Pos	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
38	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5175
# text = Both c-Fos and c-Jun protein levels were increased after Con A and PHA stimulation.
1	Both	both	DET	DT	_	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	Con	con	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	PHA	PHa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5176
# text = Since T-cell stimulation increases both intracellular Ca2+ and cAMP levels and activates protein kinase C (PKC), the possible involvement of these intracellular messengers in c-Fos and c-Jun induction was tested.
1	Since	since	ADP	IN	_	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
5	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
15	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	C	C	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
24	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
37	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5177
# text = PMA, which directly activates PKC, mimicked the effect of the lectins on c-Fos and c-Jun, but elevation of either intracellular Ca2+ or cAMP levels had little or no effect.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	directly	directly	ADV	RB	_	_	_	_	_
5	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	mimicked	mimick	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	lectins	lectin	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	either	either	CCONJ	CC	_	_	_	_	_
27	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
32	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
33	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	no	no	DET	DT	_	_	_	_	_
37	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5178
# text = The mitogen-induced increase of c-Fos and c-Jun immunoreactivity was inhibited by H-7, a kinase inhibitor with relatively high specificity for PKC, and less efficiently by H-8, a structurally related kinase inhibitor less active on PKC, but more active on cyclic nucleotide-dependent kinases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
14	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	relatively	relatively	ADV	RB	_	_	_	_	_
27	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
28	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
34	efficiently	efficiently	ADV	RB	_	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	H	H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	structurally	structurally	ADV	RB	_	_	_	_	_
42	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
43	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
44	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
45	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
46	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
47	on	on	ADP	IN	_	_	_	_	_
48	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	but	but	CCONJ	CC	_	_	_	_	_
51	more	more	ADV	RBR	_	_	_	_	_
52	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
53	on	on	ADP	IN	_	_	_	_	_
54	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
55	nucleotide	nucleotide	ADV	RB	_	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
58	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5179
# text = Con A stimulation was found to increase both binding of AP-1 to the AP-1 consensus sequence, TRE, and AP-1 enhancer activity, in Jurkat cells.
1	Con	con	NOUN	NN	Number=Sing	_	_	_	_
2	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
20	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	TRE	tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5180
# text = PMA was also found to increase the AP-1 enhancer activity, whereas elevation of Ca2+ or cAMP had only minor effects.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whereas	whereas	SCONJ	IN	_	_	_	_	_
15	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	+	+	SYM	SYM	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
21	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	only	only	ADV	RB	_	_	_	_	_
23	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
24	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5181
# text = We conclude that stimulation with mitogenic lectins is sufficient to increase both c-Fos and c-Jun protein levels, AP-1 binding and AP-1 enhancer activity in Jurkat cells and that they act via mechanisms that could involve the activation of PKC.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
7	lectins	lectin	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
38	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	via	via	ADP	IN	_	_	_	_	_
40	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
41	that	that	PRON	WDT	PronType=Rel	_	_	_	_
42	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
43	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5182
# text = Document 003001229 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001229	003001229	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5183
# text = The human myelomonocytic cell line U-937 as a model for studying alterations in steroid-induced monokine gene expression: marked enhancement of lipopolysaccharide-stimulated interleukin-1 beta messenger RNA levels by 1,25-dihydroxyvitamin D3.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	line	line	NOUN	NN	Number=Sing	_	_	_	_
6	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	937	937	NUM	CD	NumType=Card	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
14	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	monokine	monokine	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	:	:	PUNCT	:	_	_	_	_	_
23	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
33	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
34	RNA	RNA	NOUN	NN	Number=Sing	_	_	_	_
35	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
40	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5184
# text = The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], is a potent regulator of human monocyte/macrophage function in vitro.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
6	D	d	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
11	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
12	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
15	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
23	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
29	function	function	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5185
# text = To establish a model for 1,25-(OH)2D3 regulation of human monocyte monokine synthesis, three human cell lines (U-937, THP-1, and HL-60) were examined for: 1) the presence of functional 1,25-(OH)2D3 receptors; 2) the accumulation of interleukin-1 beta (IL-1 beta) mRNA and IL-1 beta protein in response to lipopolysaccharide (LPS); and 3) the regulation of this response by 1,25-(OH)2D3.
1	To	to	PART	TO	_	_	_	_	_
2	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
8	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
15	monokine	monokine	NOUN	NN	Number=Sing	_	_	_	_
16	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	three	three	NUM	CD	NumType=Card	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	HL	Hl	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	SpaceAfter=No
39	:	:	PUNCT	:	_	_	_	_	_
40	1	1	X	LS	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
46	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
48	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
51	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	;	;	PUNCT	,	_	_	_	_	_
53	2	2	X	LS	_	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
60	1	1	NUM	CD	NumType=Card	_	_	_	_
61	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
62	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
63	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	1	1	NUM	CD	NumType=Card	_	_	_	_
66	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	_
68	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
69	and	and	CCONJ	CC	_	_	_	_	_
70	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
72	1	1	NUM	CD	NumType=Card	_	_	_	_
73	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
74	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
75	in	in	ADP	IN	_	_	_	_	_
76	response	response	NOUN	NN	Number=Sing	_	_	_	_
77	to	to	ADP	IN	_	_	_	_	_
78	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
79	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
80	LPS	Lp	INTJ	UH	_	_	_	_	SpaceAfter=No
81	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
82	;	;	PUNCT	,	_	_	_	_	_
83	and	and	CCONJ	CC	_	_	_	_	_
84	3	3	X	LS	_	_	_	_	SpaceAfter=No
85	)	)	PUNCT	-RRB-	_	_	_	_	_
86	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
87	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
88	of	of	ADP	IN	_	_	_	_	_
89	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
90	response	response	NOUN	NN	Number=Sing	_	_	_	_
91	by	by	ADP	IN	_	_	_	_	_
92	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
93	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
94	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
95	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
96	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
97	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
98	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5186
# text = All three cell lines expressed vitamin D receptor and had increased levels of IL-1 beta mRNA in response to LPS.
1	All	all	DET	DT	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
7	D	would	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5187
# text = Preincubation of cells with 1,25-(OH)2D3 augmented IL-1 beta mRNA levels only in U-937 and HL-60 cells.
1	Preincubation	Preincubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
7	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
10	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	only	only	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	937	937	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	60	60	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5188
# text = From these data, and taking into consideration their state of differentiation and relative ease of culture, U-937 was chosen over HL-60 and THP-1 as the cell line we further characterized.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	taking	take	VERB	VBG	VerbForm=Ger	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	consideration	consideration	NOUN	NN	Number=Sing	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	state	state	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
15	ease	ease	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	937	937	NUM	CD	NumType=Card	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	chosen	chosen	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	over	over	ADP	IN	_	_	_	_	_
25	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	60	60	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	line	line	NOUN	NN	Number=Sing	_	_	_	_
36	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
37	further	further	ADV	RB	_	_	_	_	_
38	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5189
# text = In U-937 cells, optimum time and dose of pretreatment with 1,25-(OH)2D3 were determined to be 12-24 h at a receptor saturating concentration of 1,25-(OH)2D3 (10 nM).
1	In	in	ADP	IN	_	_	_	_	_
2	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	937	937	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	optimum	optimum	ADJ	JJ	Degree=Pos	_	_	_	_
8	time	time	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
16	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	determined	determine	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	24	24	NUM	CD	NumType=Card	_	_	_	_
26	h	h	NOUN	NN	Number=Sing	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	saturating	saturat	VERB	VBG	VerbForm=Ger	_	_	_	_
31	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
35	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	10	10	NUM	CD	NumType=Card	_	_	_	_
40	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5190
# text = Preincubation of cells with 1,25-(OH)2D3 had no effect on the time course of IL-1 beta mRNA appearance in response to LPS.
1	Preincubation	Preincubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
7	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	time	time	NOUN	NN	Number=Sing	_	_	_	_
16	course	course	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5191
# text = However, exposure of U-937 cells to 1,25-(OH)2D3 increased by 200% the level of IL-1 beta mRNA detected and decreased by three orders of magnitude the concentration of LPS required to achieve steady state mRNA levels equivalent to those observed in U-937 cells not preincubated with the hormone.2+o
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	937	937	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
12	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	200	200	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
26	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
27	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	three	three	NUM	CD	NumType=Card	_	_	_	_
32	orders	order	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
39	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	achieve	achieve	VERB	VB	VerbForm=Inf	_	_	_	_
42	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
43	state	state	NOUN	NN	Number=Sing	_	_	_	_
44	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
46	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
47	to	to	ADP	IN	_	_	_	_	_
48	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
49	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	937	937	NUM	CD	NumType=Card	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
55	not	not	PART	RB	_	_	_	_	_
56	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	with	with	ADP	IN	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	hormone.2+	hormone.2+	SYM	SYM	_	_	_	_	SpaceAfter=No
60	o	of	ADP	IN	Abbr=Yes	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5192
# text = Document 003001230 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001230	003001230	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5193
# text = Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
4	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	U937	U937	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5194
# text = Binding of type I interferon (IFN-alpha/beta) to specific receptors results in the rapid transcriptional activation, independent of protein synthesis, of IFN-alpha-stimulated genes (ISGs) in human fibroblasts and HeLa and Daudi cell lines.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	interferon	interferon	X	FW	Foreign=Yes	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-alpha/beta	-alpha/beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	results	result	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	ISGs	ISGs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5195
# text = The binding of ISGF3 (IFN-stimulated gene factor 3) to the conserved IFN-stimulated response element (ISRE) results in transcriptional activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	3	3	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	ISRE	ISRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	results	result	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5196
# text = This factor is composed of a DNA-binding protein (ISGF3 gamma), which normally is present in the cytoplasm, and other IFN-alpha-activated proteins which preexist as latent cytoplasmic precursors (ISGF3 alpha).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	normally	normally	ADV	RB	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	preexist	preexist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
36	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
37	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5197
# text = We have found that ISG expression in the monocytic U937 cell line differs from most cell lines previously examined.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ISG	ISG	VERB	VBG	VerbForm=Ger	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	previously	previously	ADV	RB	_	_	_	_	_
19	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5198
# text = U937 cells express both type I and type II IFN receptors, but only IFN-alpha is capable of inducing antiviral protection in these cells.
1	U937	U937	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	II	ii	NUM	CD	NumType=Card	_	_	_	_
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	IFN	Ifn	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	SCONJ	IN	_	_	_	_	_
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
23	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5199
# text = Pretreatment with IFN-gamma potentiates the IFN-alpha-induced protection, but IFN-gamma alone does not have any antiviral activity.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
6	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	protection	protection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
19	alone	alone	ADV	RB	_	_	_	_	_
20	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
23	any	any	DET	DT	_	_	_	_	_
24	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5200
# text = ISG15 mRNA accumulation in U937 cells is not detectable before 6 h of IFN-alpha treatment, peaks at 24 h, and requires protein synthesis.
1	ISG15	ISG15	NUM	CD	NumType=Card	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	U937	U937	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
10	before	before	ADP	IN	_	_	_	_	_
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	peaks	peak	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	24	24	NUM	CD	NumType=Card	_	_	_	_
22	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5201
# text = Although IFN-gamma alone does not induce ISG expression, IFN-gamma pretreatment markedly increases and hastens ISG expression and transcriptional induction.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
5	alone	alone	NOUN	NN	Number=Sing	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
9	ISG	ISG	PROPN	NNP	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
15	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
16	markedly	markedly	ADV	RB	_	_	_	_	_
17	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	hastens	hasten	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	ISG	ISG	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5202
# text = Nuclear extracts assayed for the presence of ISRE binding factors by electrophoretic mobility shift assays show that ISGF3 is induced by IFN-alpha within 6
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ISRE	Isre	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
13	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
14	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
15	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
16	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	alpha	alpha	ADV	RB	_	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	6	6	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 5203
# text = h from undetectable basal levels in untreated U937 cells.
1	h	h	INTJ	UH	_	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
4	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
8	U937	U937	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5204
# text = Activation of ISGF3 alpha, the latent component of ISGF3, occurs rapidly.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
8	component	component	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	occurs	occurs	ADV	RB	_	_	_	_	_
13	rapidly	rapidly	ADV	RB	_	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5205
# text = However, the increase in ISGF3 activity ultimately correlates with the accumulation of ISGF3 gamma induced by IFN-alpha or IFN-gamma.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	ultimately	ultimately	ADV	RB	_	_	_	_	_
9	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	ISGF3	ISGF3	NUM	CD	NumType=Card	_	_	_	_
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5206
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5207
# text = Document 003001242 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001242	003001242	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5208
# text = Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains.
1	Clone	Clone	PROPN	NNP	Number=Sing	_	_	_	_
2	pAT	pAT	PROPN	NNP	Number=Sing	_	_	_	_
3	133	133	NUM	CD	NumType=Card	_	_	_	_
4	identifies	identify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	another	another	DET	DT	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	member	member	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-induced	-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	almost	almost	ADV	RB	_	_	_	_	_
22	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
23	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
26	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5209
# text = We report the structure and regulation of a gene represented by clone pAT 133, which is induced upon transition from a resting state (G0) through the early phase of the cell cycle (G1).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
13	pAT	pat	NOUN	NN	Number=Sing	_	_	_	_
14	133	133	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	upon	upon	ADP	IN	_	_	_	_	_
20	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	resting	resting	VERB	VBG	VerbForm=Ger	_	_	_	_
24	state	state	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	G0	G0	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
31	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	G1	G1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5210
# text = The pAT 133 gene is immediately induced, with FOS-like kinetics, in human T cells and in fibroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pAT	pat	NOUN	NN	Number=Sing	_	_	_	_
3	133	133	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	immediately	immediately	ADV	RB	_	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5211
# text = Primary structure analysis showed that the encoded protein contains three tandem zinc-finger sequences of the type Cys2-Xaa12-His2.
1	Primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
2	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
12	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
15	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	Cys2-Xaa12	Cys2-Xaa12	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	His2	His2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5212
# text = This zinc-finger region, which is thought to bind DNA in a sequence-specific manner, is similar (greater than 80% on the amino acid level) to two previously described transcription factors pAT 225/EGR1 and pAT 591/EGR2.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
24	than	than	ADP	IN	_	_	_	_	_
25	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	amino	amino	DET	DT	_	_	_	_	_
30	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
31	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	two	two	NUM	CD	NumType=Card	_	_	_	_
35	previously	previously	ADV	RB	_	_	_	_	_
36	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
39	pAT	pAT	NOUN	NN	Number=Sing	_	_	_	_
40	225/	225/	SYM	SYM	_	_	_	_	SpaceAfter=No
41	EGR1	EGR1	NUM	CD	NumType=Card	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	pAT	pAT	NOUN	NN	Number=Sing	_	_	_	_
44	591/	591ith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5213
# text = Except for the conserved zinc-finger domains, the amino acid sequences of the three proteins are distinct.
1	Except	except	ADP	IN	_	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
8	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5214
# text = This structural similarity suggests that the pAT 133 gene encodes a transcription factor with a specific biological function.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
3	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
4	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	pAT	pat	NOUN	NN	Number=Sing	_	_	_	_
8	133	133	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5215
# text = Comparing the regulation of these related zinc-finger-encoding genes showed coordinate induction upon mitogenic stimulation of resting T lymphocytes and of resting fibroblasts.
1	Comparing	compare	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
7	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	finger	finger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-encoding	-encoding	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	upon	upon	ADP	IN	_	_	_	_	_
16	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	SCONJ	IN	_	_	_	_	_
19	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	of	of	SCONJ	IN	_	_	_	_	_
24	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5216
# text = However, upon transition from a proliferating (G1) to a resting state of the cell cycle the three genes were differently regulated.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	upon	upon	ADP	IN	_	_	_	_	_
4	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	proliferating	proliferating	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	G1	G1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
14	state	state	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	three	three	NUM	CD	NumType=Card	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	differently	differently	ADV	RB	_	_	_	_	_
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5217
# text = In human histiocytic U937 cells mRNA of clone pAT 133 was constitutively expressed, whereas mRNA of pAT 225/EGR1 was induced upon induction of terminal differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	histiocytic	histiocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	mRNA	mRNa	ADP	IN	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	pAT	pat	NOUN	NN	Number=Sing	_	_	_	_
10	133	133	NUM	CD	NumType=Card	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	constitutively	constitutively	ADV	RB	_	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	pAT	pAT	PROPN	NNP	Number=Sing	_	_	_	_
19	225/	225/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	EGR1	EGR1	PROPN	NNP	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	upon	upon	ADP	IN	_	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5218
# text = In contrast mRNA representing pAT 591/EGR2 was not expressed in these cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
3	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
4	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
5	pAT	pat	NOUN	NN	Number=Sing	_	_	_	_
6	591/	591/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5219
# text = This difference in gene regulation suggests distinct biological roles in the control of cell proliferation for the respective proteins.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
8	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
9	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5220
# text = Document 003001243 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001243	003001243	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5221
# text = Interferon-alpha activates multiple
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 5222
# text = STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	upregulates	upregulate	NOUN	NNS	Number=Plur	_	_	_	_
5	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	myc	myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	pim	pim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	T	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5223
# text = Interferon-alpha (IFN-alpha) is a pleiotropic cytokine that has antiviral, antiproliferative, and immunoregulatory functions.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5224
# text = There is increasing evidence that IFN-alpha has an important role in T-cell biology.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	biology	biology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5225
# text = We have analyzed the expression of IL-2Ralpha, c-myc, and pim-1 genes in anti-CD3-activated human T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	pim	pim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-activated	-activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5226
# text = The induction of these genes is associated with interleukin-2 (IL-2)-induced T-cell proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5227
# text = Treatment of T lymphocytes with IFN-alpha, IL-2, IL-12, and IL-15 upregulated IL-2Ralpha, c-myc, and pim-1 gene expression.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-12	-12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	15	15	NUM	CD	NumType=Card	_	_	_	_
21	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	pim	pim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5228
# text = IFN-alpha also sensitized T cells to IL-2-induced proliferation, further suggesting that IFN-alpha may be involved in the regulation of T-cell mitogenesis.
1	IFN-	IFN-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	sensitized	sensitize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	T	t	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	further	further	ADV	RB	_	_	_	_	_
16	suggesting	suggesting	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5229
# text = When we analyzed the nature of STAT proteins capable of binding to IL-2Ralpha, pim-1, and IRF-1 GAS elements after cytokine stimulation, we observed IFN-alpha-induced binding of STAT1, STAT3, and STAT4, but not STAT5 to all of these elements.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	Ralpha	Ralpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	pim	pim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
26	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	observed	observe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	STAT4	STAT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	but	but	CCONJ	CC	_	_	_	_	_
48	not	not	ADV	RB	_	_	_	_	_
49	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	all	all	DET	DT	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5230
# text = Yet, IFN-alpha was able to activate binding of STAT5 to the high-affinity IFP53 GAS site.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
18	IFP53	IFP53	NUM	CD	NumType=Card	_	_	_	_
19	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5231
# text = IFN-alpha enhanced tyrosine phosphorylation of STAT1, STAT3, STAT4, STAT5a, and STAT5b.
1	IFN	Ifn	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	STAT4	STAT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	STAT5a	STAT5a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5232
# text = IL-12 induced STAT4 and IL-2 and IL-15 induced STAT5 binding to the GAS elements.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	STAT4	Stat4	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	15	15	NUM	CD	NumType=Card	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5233
# text = Taken together, our results suggest that IFN-alpha, IL-2, IL-12, and IL-15 have overlapping activities on human T cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-12	-12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	15	15	NUM	CD	NumType=Card	_	_	_	_
23	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	overlapping	overlapp	ADJ	JJ	Degree=Pos	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5234
# text = These findings thus emphasize the importance of IFN-alpha as a T-cell regulatory cytokine.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	emphasize	emphasize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5235
# text = Document 003001246 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001246	003001246	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5236
# text = An alternatively spliced isoform of the Spi-B transcription factor.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	alternatively	alternatively	ADV	RB	_	_	_	_	_
3	spliced	spliced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5237
# text = Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-B	-B	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
12	Spi-1/	spi-1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	highly	highly	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5238
# text = The Ets proteins share a conserved Ets domain that mediates specific DNA binding.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5239
# text = Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-B	-B	PROPN	NNP	Number=Sing	_	_	_	_
3	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	GGAA	GGAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5240
# text = Up to date, the biological function of Spi-B remains unknown.
1	Up	up	ADP	IN	_	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	date	date	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5241
# text = Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	alternatively	alternatively	ADV	RB	_	_	_	_	_
10	spliced	spliced	ADJ	JJ	Degree=Pos	_	_	_	_
11	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	named	name	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	deltaSpi	deltaSpi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-B	-B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Ets	Et	PROPN	NNPS	Number=Plur	_	_	_	_
26	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5242
# text = In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%.
1	In	in	ADP	IN	_	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	deltaspi	deltaspi	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-B	-b	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	spi	spi	X	AFX	_	_	_	_	SpaceAfter=No
10	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
11	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	around	around	ADV	RB	_	_	_	_	_
20	10%	10%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5243
# text = DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts.
1	DeltaSpi	DeltaSpi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-B	-b	PROPN	NNP	Number=Sing	_	_	_	_
3	product	product	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	recovered	recover	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5244
# text = We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	raise	raise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
7	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
11	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
12	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	recruiting	recruite	VERB	VBG	VerbForm=Ger	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5245
# text = Document 003001250 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001250	003001250	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5246
# text = ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.
1	ZAP	Zap	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	70	70	NUM	CD	NumType=Card	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	UV	UV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5247
# text = Several mammalian responses to UV irradiation, including the activation of NF-kappa B, are believed to involve tyrosine phosphorylation.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
3	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
6	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
21	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5248
# text = UV irradiation and H2O2 treatment of T lymphocytes induce protein tyrosine phosphorylation and Ca2+ signals similar to those observed following biological stimulation.
1	UV	UV	NOUN	NN	Number=Sing	_	_	_	_
2	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
22	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5249
# text = We have examined the role of cell surface molecules in these responses.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5250
# text = Normal T lymphocytes whose surface expression of CD3 was depleted showed impaired UV-induced tyrosine phosphorylation and Ca2+ signals.
1	Normal	normal	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
5	surface	surface	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	showed	show	ADJ	JJ	Degree=Pos	_	_	_	_
12	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	UV	UV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5251
# text = Similarly, Jurkat T cell lines deficient in CD3 or CD45 expression also gave impaired UV responses.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	CD45	CD45	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	gave	give	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
16	UV	uv	NOUN	NN	Number=Sing	_	_	_	_
17	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5252
# text = However, all these cell types still gave strong Ca2+ and tyrosine phosphorylation responses to H2O2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	all	all	DET	PDT	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	types	type	NOUN	NNS	Number=Plur	_	_	_	_
7	still	still	ADV	RB	_	_	_	_	_
8	gave	give	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
10	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	+	+	SYM	SYM	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5253
# text = The T cell tyrosine kinase ZAP-70 was found to be highly responsive to UV and H2O2 treatment.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	ZAP	Zap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	70	70	NUM	CD	NumType=Card	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5254
# text = ZAP-70 responsiveness to UV required expression of both CD3 and CD45, whereas only CD3 was required for the response to H2O2.
1	ZAP	Zap	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	70	70	NUM	CD	NumType=Card	_	_	_	_
4	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD45	Cd45	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5255
# text = UV-induced activation of NF-kappa B was blocked by CD3 depletion, indicating the importance of such cell surface molecules in biological responses to UV.
1	UV	haUve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
14	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
26	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	UV	UV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5256
# text = In nonlymphoid cells, the epidermal growth factor receptor displayed increased tyrosine phosphorylation within seconds of UV irradiation.
1	In	in	ADP	IN	_	_	_	_	_
2	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	epidermal	epidermal	ADJ	JJ	Degree=Pos	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	seconds	seconds	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
18	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5257
# text = These results suggest that UV-induced signal transduction is mediated via cell surface receptors that normally respond to biological stimulation, whereas
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	UV	uv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	normally	normally	ADV	RB	_	_	_	_	_
18	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	wherea	SCONJ	IN	_	_	_	_	_

# sent_id = 5258
# text = H2O2 is able to partially bypass this requirement.
1	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	partially	partially	ADV	RB	_	_	_	_	_
6	bypass	bypass	VERB	VB	VerbForm=Inf	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5259
# text = Document 003001256 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001256	003001256	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5260
# text = Bcl-2 protein inhibits bufalin-induced apoptosis through inhibition of mitogen-activated protein kinase activation in human leukemia U937 cells.
1	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
6	bufalin-	bufalin-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	leukemia	leukemion	NOUN	NN	Number=Sing	_	_	_	_
21	U937	U937	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5261
# text = In a previous study, we demonstrated that bufalin, which is an active principle of Chinese medicine, chan'su, caused apoptosis in human leukemia U937 cells by anomalous activation of mitogen-activated protein kinase (MAPK) via the signaling pathway of Ras, Raf-1, and MAPK kinase-1.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
15	principle	principle	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
18	medicine	medicine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	chan	chan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	'su	'su	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	leukemia	leukemion	NOUN	NN	Number=Sing	_	_	_	_
28	U937	U937	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	anomalous	anomalous	ADJ	JJ	Degree=Pos	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
36	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	via	via	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
45	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
55	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5262
# text = Here, we report the effect of overexpression of bcl-2 in U937 cells on the signaling pathway of apoptosis that is induced by bufalin.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5263
# text = The results indicated that the apoptosis induced by bufalin in U937 cells was significantly inhibited by overexpression of the Bcl-2 protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	significantly	significantly	ADV	RB	_	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5264
# text = No significant difference was detected in the activation of MAPK kinase-1 that is induced by bufalin in wild-type or Bcl-2-overexpressed
1	No	no	DET	DT	_	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 5265
# text = U937 cells; however, the activation of MAPK by bufalin was significantly attenuated in the cells overexpressing Bcl-2.
1	U937	U937	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	;	;	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	bufalin	bufalin	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5266
# text = Bufalin treatment activated activator protein-1 transcriptional activity; however, this activation was decreased to 40% in bcl-2-overexpressed U937 cells.
1	Bufalin	Bufalin	PROPN	NNP	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	%	%	SYM	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	U937	U937	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5267
# text = These results indicate that Bcl-2 acts downstream of MAPK kinase-1 but upstream of MAPK and suggest that, in the signaling pathway of the apoptotic process induced by bufalin, the transcriptional activity of activator protein-1 may be down-regulated through the inhibition of MAPK activity by Bcl-2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
9	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
21	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
30	process	process	NOUN	NN	Number=Sing	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	bufalin	bufalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
44	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
45	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	through	through	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
53	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
54	by	by	ADP	IN	_	_	_	_	_
55	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5268
# text = Document 003001257 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001257	003001257	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5269
# text = Activation of NF-kappaB in Mycobacterium tuberculosis- induced interleukin-2 receptor expression in mononuclear phagocytes.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
8	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5270
# text = Soluble interleukin-2 receptor-alpha (IL-2Ralpha) has been reported to be increased in the sera of patients with advanced tuberculosis, and levels decline after therapy in accordance with improvement of radiologic findings.
1	Soluble	Soluble	ADJ	JJ	Degree=Pos	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	sera	sera	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
27	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	decline	decline	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	after	after	ADP	IN	_	_	_	_	_
33	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	accordance	accordance	NOUN	NN	Number=Sing	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	improvement	improvement	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	radiologic	radiologic	ADJ	JJ	Degree=Pos	_	_	_	_
40	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5271
# text = We investigated expression of the IL-2Ralpha in bronchoalveolar lavage (BAL) cells in active pulmonary tuberculosis, and evaluated the mechanism Mycobacterium tuberculosis induces in the IL-2Ralpha using the THP-1 mononuclear phagocyte cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	bronchoalveolar	bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
12	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	BAL	Bal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
19	pulmonary	pulmonary	NOUN	NN	Number=Sing	_	_	_	_
20	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
26	Mycobacterium	Mycobacterium	NOUN	NN	Number=Sing	_	_	_	_
27	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
28	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
35	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
41	phagocyte	phagocyte	NOUN	NN	Number=Sing	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5272
# text = We found IL-2Ralpha expression to be increased in BAL cells from involved sites of active pulmonary tuberculosis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	BAL	Bal	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
19	pulmonary	pulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
20	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5273
# text = Expression of the alpha-chain of IL-2Ralpha on peripheral blood monocytes (PBM) was induced by M. tuberculosis by flow cytometry evaluation.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	Ralpha	Ralpha	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	PBM	PBm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
22	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
25	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
26	evaluation	evaluation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5274
# text = Northern analysis demonstrated increased IL-2Ralpha gene expression after stimulation with M.
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5275
# text = tuberculosis which was further induced by interferon-gamma (IFN-gamma).
1	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
2	which	which	PRON	WDT	PronType=Rel	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5276
# text = The IL-2Ralpha promoter containing the nuclear factor kappa B (NF-kappaB) site was transcriptionally induced by M.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5277
# text = tuberculosis and this NF-kappaB site could confer inducibility to a heterologous herpes thymidine kinase (TK) promoter by M.
1	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
10	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
14	herpes	herpes	NOUN	NN	Number=Sing	_	_	_	_
15	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TK	TK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5278
# text = tuberculosis.
1	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5279
# text = Electrophoretic mobility shift assays (EMSAs) revealed specific binding of nuclear protein to the NF-kappaB site upon induction with M. tuberculosis.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	upon	upon	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
24	tuberculosis	tuberculosis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5280
# text = Using antibodies against the p50 and p65 subunits of NF-kappaB in EMSAs, the involvement of both p50 and p65 proteins was further demonstrated.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
3	against	against	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
8	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	p50	p50	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p65	p65	NUM	CD	NumType=Card	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	further	further	ADV	RB	_	_	_	_	_
26	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5281
# text = Functional expression of the IL-2Ralpha on mononuclear phagocytes in M. tuberculosis infection may play an important immunomodulatory role in the host response.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	Ralpha	Ralpha	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
14	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
15	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	host	host	NOUN	NN	Number=Sing	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5282
# text = Document 003001258 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001258	003001258	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5283
# text = Regulation of the beta-globin locus.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
7	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5284
# text = Transcription of the human beta-globin gene cluster depends upon upstream regulatory sequences, which are collectively termed the locus control region.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
10	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	collectively	collectively	ADV	RB	_	_	_	_	_
19	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	locus	locus	ADJ	JJ	Degree=Pos	_	_	_	_
22	control	control	NOUN	NN	Number=Sing	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5285
# text = Recent studies have provided new insights into how the individual genes of the cluster are regulated through development.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
7	into	into	SCONJ	IN	_	_	_	_	_
8	how	how	ADV	WRB	PronType=Int	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5286
# text = The crux of transcriptional activation is how the locus control region communicates with the gene-proximal regulatory elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	crux	crux	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	how	how	ADV	WRB	PronType=Int	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	locus	locus	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	communicates	communicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	gene-	gene-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5287
# text = Document 003001268 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001268	003001268	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5288
# text = Induction of NF-KB during monocyte differentiation by HIV type 1 infection.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5289
# text = The production of human immunodeficiency virus type 1 (HIV-1) progeny was followed in the U937 promonocytic cell line after stimulation either with retinoic acid or PMA, and in purified human monocytes and macrophages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	U937	U937	NUM	CD	NumType=Card	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	_
23	after	after	ADP	IN	_	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	either	either	CCONJ	CC	_	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
28	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5290
# text = Electrophoretic mobility shift assays and Southwestern blotting experiments were used to detect the binding of cellular transactivation factor NF-KB to the double repeat-KB enhancer sequence located in the long terminal repeat.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Southwestern	southwestern	ADJ	JJ	Degree=Pos	_	_	_	_
7	blotting	blotting	ADJ	JJ	Degree=Pos	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	double	double	ADJ	JJ	Degree=Pos	_	_	_	_
25	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
30	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
34	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
35	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5291
# text = PMA treatment, and not retinoic acid treatment of the U937 cells acts in inducing NF-KB expression in the nuclei.
1	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5292
# text = In nuclear extracts from monocytes or macrophages, induction of NF-KB occurred only if the cells were previously infected with HIV-1.
1	In	in	ADP	IN	_	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
14	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	if	if	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5293
# text = When U937 cells were infected with HIV-1, no induction of NF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	U937	U937	NUM	CD	NumType=Card	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
26	virions	virion	NOUN	NNS	Number=Plur	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
39	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5294
# text = These results indicate that in monocytic cell lineage, HIV-1 could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
14	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
15	some	some	DET	DT	_	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
20	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5295
# text = Document 003001281 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001281	003001281	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5296
# text = STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules.
1	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	during	during	ADP	IN	_	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
7	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5297
# text = Human monocytes isolated from peripheral blood of healthy donors show a time-dependent differentiation into macrophages upon in vitro cultivation, closely mimicking their in vivo migration and maturation into extravascular tissues.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
9	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
10	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	into	into	ADP	IN	_	_	_	_	_
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	upon	upon	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
21	cultivation	cultivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	closely	closely	ADV	RB	_	_	_	_	_
24	mimicking	mimick	VERB	VBG	VerbForm=Ger	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
28	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
31	into	into	ADP	IN	_	_	_	_	_
32	extravascular	extravascular	ADJ	JJ	Degree=Pos	_	_	_	_
33	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5298
# text = The mediator(s) of this maturation process has not been yet defined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
9	process	process	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	yet	yet	ADV	RB	_	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5299
# text = We investigated the involvement of signal transducers and activators of transcription (STAT) factors in this phenomenon and reported the specific, time-dependent, activation of STAT1 protein starting at day 0/1 of cultivation and maximally expressed at day 5.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
7	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	starting	start	VERB	VBG	VerbForm=Ger	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	day	day	NOUN	NN	Number=Sing	_	_	_	_
35	0/1	0/1	NUM	CD	NumType=Card	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	cultivation	cultivation	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	maximally	maximally	ADV	RB	_	_	_	_	_
40	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	at	at	ADP	IN	_	_	_	_	_
42	day	day	NOUN	NN	Number=Sing	_	_	_	_
43	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5300
# text = STAT1 activity was evident on the STAT binding sequences (SBE) present in the promoters of genes which are up-regulated during monocyte to macrophage maturation such as FcgammaRI and ICAM-1, and in the promoter of the transcription factor IFN regulatory factor-1.
1	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	SBE	SBE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	macrophage	macrophage	VERB	VB	VerbForm=Inf	_	_	_	_
28	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
29	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	FcgammaRI	Fcgammari	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	IFN	Ifn	ADP	IN	_	_	_	_	_
46	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5301
# text = Moreover, the effect of cell adhesion to fibronectin or laminin was studied to investigate mechanisms involved in STAT1 activation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	laminin	laminin	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
16	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5302
# text = Compared with monocytes adherent on plastic surfaces, freshly isolated cells allowed to adhere either to fibronectin- or laminin-coated flasks exhibited an increased STAT1 binding activity both in control and in IFN-gamma-treated cells.
1	Compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
7	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	freshly	freshly	ADV	RB	_	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	adhere	adhere	VERB	VB	VerbForm=Inf	_	_	_	_
15	either	either	ADV	RB	_	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	fibronectin	fibronectin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	laminin	laminin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	coated	coate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	flasks	flask	NOUN	NNS	Number=Plur	_	_	_	_
24	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	STAT1	stat1	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5303
# text = The molecular events leading to enhanced STAT1 activation and cytokine responsiveness concerned both Y701 and S727 STAT1 phosphorylation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
7	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
12	concerned	concern	ADJ	JJ	Degree=Pos	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	Y701	Y701	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	S727	S727	NUM	CD	NumType=Card	_	_	_	_
17	STAT1	STAT1	NOUN	NN	Number=Sing	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5304
# text = Exogenous addition of transforming growth factor-beta, which exerts an inhibitory effect on some monocytic differentiation markers, inhibited macrophage maturation, integrin expression and STAT1 binding activity.
1	Exogenous	Exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	SCONJ	IN	_	_	_	_	_
4	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	some	some	DET	DT	_	_	_	_	_
17	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
23	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
29	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5305
# text = Taken together these results indicate that STAT1 plays a pivotal role in the differentiation/maturation process of monocytes as an early transcription factor initially activated by adherence and then able to modulate the expression of functional genes, such as ICAM-1 and FcgammaRI.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
17	process	process	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	initially	initially	ADV	RB	_	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	then	then	ADV	RB	PronType=Dem	_	_	_	_
31	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	FcgammaRI	FcgammaRI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5306
# text = Document 003001285 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001285	003001285	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5307
# text = Quantification of vitamin D receptor mRNA by competitive polymerase chain reaction in PBMC: lack of correspondence with common allelic variants.
1	Quantification	Quantification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
4	D	would	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
9	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
10	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
11	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	correspondence	correspondence	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
20	allelic	allelic	ADJ	JJ	Degree=Pos	_	_	_	_
21	variants	variant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5308
# text = It has been recently claimed that polymorphism for the vitamin D receptor (VDR) influences several aspects of calcium and bone metabolism.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	recently	recently	ADV	RB	_	_	_	_	_
5	claimed	claim	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
11	D	d	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
18	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
23	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5309
# text = To evaluate the physiologic plausibility of these claims, we compared the abundance of the VDR mRNA in peripheral blood mononuclear cells (PBMCs) between different VDR genotypes using a quantitative reverse transcribed polymerase chain reaction-based method.
1	To	to	PART	TO	_	_	_	_	_
2	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
5	plausibility	plausibility	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	claims	claim	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	PBMCs	Pbmcs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
29	genotypes	genotype	NOUN	NNS	Number=Plur	_	_	_	_
30	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
33	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
34	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
36	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
37	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	method	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5310
# text = The method is based on the coamplification of VDR cDNA and an internal standard consisting of known concentrations of a human VDR CDNA mutated at a BglII restriction site; the interassay coefficient of variation is 11%.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	method	method	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	coamplification	coamplification	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
10	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
14	standard	standard	NOUN	NN	Number=Sing	_	_	_	_
15	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
23	CDNA	CDNA	PROPN	NNP	Number=Sing	_	_	_	_
24	mutated	mutate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	BglII	Bglii	PROPN	NNP	Number=Sing	_	_	_	_
28	restriction	restriction	NOUN	NN	Number=Sing	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	;	;	PUNCT	,	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	interassay	interassay	ADJ	JJ	Degree=Pos	_	_	_	_
33	coefficient	coefficient	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	11%	11%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5311
# text = To validate the method, we made use of earlier receptor binding studies indicating that normal human monocytes and activated, but not resting, lymphocytes expressed the VDR.
1	To	to	PART	TO	_	_	_	_	_
2	validate	validate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	method	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	made	make	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	use	use	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	ADV	RB	_	_	_	_	_
24	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
27	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5312
# text = The concentration of the VDR mRNA was 10(-8) to 10(-7) g/g of total RNA in cell-sorted monocytes and in in vitro activated lymphocytes, but only 10(-12) g/g of total mRNA in resting lymphocytes, establishing that the VDR mRNA determined by our method in PBMCs is due to constitutive expression in monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
10	8	8	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
15	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	g/g	g/g	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
20	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	cell	cell	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	sorted	sort	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
30	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	only	only	ADV	RB	_	_	_	_	_
35	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
37	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	g/g	g/g	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
42	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	SCONJ	IN	_	_	_	_	_
44	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
45	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	establishing	establish	VERB	VBG	VerbForm=Ger	_	_	_	_
48	that	that	SCONJ	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
51	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
52	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	by	by	ADP	IN	_	_	_	_	_
54	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
55	method	method	NOUN	NN	Number=Sing	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	PBMCs	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
58	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
59	due	due	ADP	IN	_	_	_	_	_
60	to	to	ADP	IN	_	_	_	_	_
61	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
62	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5313
# text = Following an initial genotype screening of 85 normal volunteers by polymerase chain reaction or restriction fragment length polymorphism analysis, 14 individuals with the Bb genotype, 12 with the bb genotype, and 12 with the BB genotype were selected.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
4	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	_
5	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	85	85	NUM	CD	NumType=Card	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	volunteers	volunteer	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
12	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
13	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	restriction	restriction	NOUN	NN	Number=Sing	_	_	_	_
16	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
17	length	length	NOUN	NN	Number=Sing	_	_	_	_
18	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	14	14	NUM	CD	NumType=Card	_	_	_	_
22	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Bb	Bb	PROPN	NNP	Number=Sing	_	_	_	_
26	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	12	12	NUM	CD	NumType=Card	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	bb	bb	NOUN	NN	Number=Sing	_	_	_	_
32	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	12	12	NUM	CD	NumType=Card	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	BB	BB	PROPN	NNP	Number=Sing	_	_	_	_
39	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	selected	select	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5314
# text = The concentration of the VDR mRNA, corrected for the number of monocytes, was similar among the three genotype groups, as were the other variables examined: serum calcitriol, serum osteocalcin, and vertebral and hip bone density.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	corrected	correct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	number	number	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
17	among	among	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	three	three	NUM	CD	NumType=Card	_	_	_	_
20	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	_
21	groups	group	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
27	variables	variable	NOUN	NNS	Number=Plur	_	_	_	_
28	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
31	calcitriol	calcitriol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
34	osteocalcin	osteocalcin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	vertebral	vertebral	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	hip	hip	ADJ	JJ	Degree=Pos	_	_	_	_
40	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
41	density	density	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5315
# text = We conclude that VDR polymorphism does not affect the abundance of the VDR mRNA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
5	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
14	mRNA.	mRNA.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5316
# text = Document 003001286 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001286	003001286	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5317
# text = Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	beta-catenin	beta-catenin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5318
# text = In response to activation of the Wnt signaling pathway, beta-catenin accumulates in the nucleus, where it cooperates with LEF/TCF (for lymphoid enhancer factor and T-cell factor) transcription factors to activate gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Wnt	Wnt	PROPN	NNP	Number=Sing	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
14	accumulates	accumulate	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	where	where	ADV	WRB	PronType=Rel	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	for	for	ADP	IN	_	_	_	_	_
28	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5319
# text = The mechanisms by which beta-catenin undergoes this shift in location and participates in activation of gene transcription are unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	DET	WDT	PronType=Int	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
8	undergoes	undergo	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	location	location	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5320
# text = We demonstrate here that beta-catenin can be imported into the nucleus independently of LEF/TCF binding, and it may also be exported from nuclei.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	imported	import	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
14	independently	independently	ADV	RB	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	exported	export	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5321
# text = We have introduced a small deletion within beta-catenin (Delta19) that disrupts binding to LEF-1, E-cadherin, and APC but not axin.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Delta19	Delta19	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	disrupts	disrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cadherin	cadherin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	APC	APC	PROPN	NNP	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	axin	axin	ADV	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5322
# text = This Delta19 beta-catenin mutant localizes to the nucleus because it may not be efficiently sequestered in the cytoplasm.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	Delta19	Delta19	PROPN	NNP	Number=Sing	_	_	_	_
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	localizes	localize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
11	because	because	SCONJ	IN	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	efficiently	efficiently	ADV	RB	_	_	_	_	_
17	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5323
# text = The nuclear localization of Delta19 definitively demonstrates that the mechanisms by which beta-catenin localizes in the nucleus are completely independent of LEF/TCF factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Delta19	Delta19	PROPN	NNP	Number=Sing	_	_	_	_
6	definitively	definitively	ADV	RB	_	_	_	_	_
7	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
16	localizes	localize	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	completely	completely	ADV	RB	_	_	_	_	_
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5324
# text = beta-Catenin and LEF-1 complexes can activate reporter gene expression in a transformed T-lymphocyte cell line (Jurkat) but not in normal T lymphocytes, even though both factors are nuclear.
1	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Catenin	Catenin	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	T	PROPN	NNP	Number=Sing	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	even	even	ADV	RB	_	_	_	_	_
32	though	though	SCONJ	IN	_	_	_	_	_
33	both	both	DET	DT	_	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5325
# text = Thus, localization of both factors to the nucleus is not sufficient for activation of gene expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5326
# text = Excess beta-catenin can squelch reporter gene activation by LEF-1-beta-catenin complexes but not activation by the transcription factor VP16.
1	Excess	Excess	NOUN	NN	Number=Sing	_	_	_	_
2	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	squelch	squelch	VERB	VB	VerbForm=Inf	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	LEF	LEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1-beta	1-beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	VP	vp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5327
# text = Taken together, these data suggest that a third component is necessary for gene activation and that this third component may vary with cell type.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
20	component	component	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	vary	vary	VERB	VB	VerbForm=Inf	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5328
# text = Document 003001287 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001287	003001287	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5329
# text = Every enhancer works with every promoter for all the combinations tested: could new regulatory pathways evolve by enhancer shuffling?
1	Every	every	DET	DT	_	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	works	work	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	every	every	DET	DT	_	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	all	all	DET	PDT	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
11	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
14	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	evolve	evolve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	shuffling	shuffling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	?	?	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5330
# text = The promoters and enhancers of cell type-specific genes are often conserved in evolution, and hence one might expect that a given enhancer has evolved to work best with its own promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	often	often	ADV	RB	_	_	_	_	_
13	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	evolution	evolution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	hence	hence	ADV	RB	_	_	_	_	_
19	one	one	PRON	PRP	_	_	_	_	_
20	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
21	expect	expect	VERB	VB	VerbForm=Inf	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	evolved	evolve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	work	work	VERB	VB	VerbForm=Inf	_	_	_	_
30	best	best	ADV	RBS	Degree=Sup	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5331
# text = While this expectation may be realized in some cases, we have not found evidence for it.
1	While	while	SCONJ	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	expectation	expectation	NOUN	NN	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	realized	realize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	some	some	DET	DT	_	_	_	_	_
9	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5332
# text = A total of 27 combinations of different promoters and enhancers were tested by transfection into cultured cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	total	total	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	27	27	NUM	CD	NumType=Card	_	_	_	_
5	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5333
# text = We found that the relative efficiency of the enhancers is approximately the same, irrespective of the type of promoter used, i.e., there was no strong preference for any given enhancer/promoter combination.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
6	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	approximately	approximately	ADV	RB	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	same	same	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	irrespective	irrespective	ADJ	JJ	Degree=Pos	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	there	there	PRON	EX	_	_	_	_	_
26	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	no	no	DET	DT	_	_	_	_	_
28	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
29	preference	preference	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	any	any	DET	DT	_	_	_	_	_
32	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
36	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5334
# text = Notably, we do not see particularly strong transcription when the immunoglobulin kappa enhancer (or the immunoglobulin heavy chain enhancer) is used to activate a kappa gene promoter.
1	Notably	notably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	see	see	VERB	VB	VerbForm=Inf	_	_	_	_
7	particularly	particularly	ADV	RB	_	_	_	_	_
8	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	or	or	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
19	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
20	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5335
# text = We propose that a generally permissive enhancer/promoter interaction is of evolutionary benefit for higher eukaryotes:
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	generally	generally	ADV	RB	_	_	_	_	_
6	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	evolutionary	evolutionary	ADJ	JJ	Degree=Pos	_	_	_	_
14	benefit	benefit	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
17	eukaryotes	eukaryote	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 5336
# text = by enhancer shuffling, genes could be easily brought under a new type of inducibility/cell type specificity.
1	by	by	ADP	IN	_	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	shuffling	shuffling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	easily	easily	ADV	RB	_	_	_	_	_
9	brought	bring	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	under	under	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5337
# text = Document 003001291 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001291	003001291	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5338
# text = Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.
1	Single	single	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	reveals	reveal	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	threshold	threshold	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	emanating	emanat	VERB	VBG	VerbForm=Ger	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5339
# text = Stimulation of T lymphocytes through their antigen receptor leads to the appearance of several transcription factors, including NF-AT and NF-kappa B, which are involved in regulating genes required for immunologic activation.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	SCONJ	IN	_	_	_	_	_
32	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
34	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5340
# text = To investigate the activity of a single transcription factor in individual viable cells, we have applied an assay that uses the fluorescence-activated cell sorter to quantitate beta-galactosidase (beta-gal).
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
12	viable	viable	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	sorter	sorter	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	quantitate	quantitate	VERB	VB	VerbForm=Inf	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	galactosidase	galactosidase	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	gal	gal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5341
# text = We have analyzed the distribution of NF-AT transcriptional activity among T cells undergoing activation by using a construct in which three tandem copies of the NF-AT-binding site directs transcription of the lacZ gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	among	among	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	undergoing	undergoing	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	three	three	NUM	CD	NumType=Card	_	_	_	_
24	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
25	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	directs	direct	NOUN	NNS	Number=Plur	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	lacZ	lacZ	PROPN	NNP	Number=Sing	_	_	_	_
39	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5342
# text = Unexpectedly, stimulation of cloned stably transfected Jurkat T cells leads to a bimodal pattern of beta-gal expression in which some cells express no beta-gal and others express high levels.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	stably	stably	ADV	RB	Degree=Pos	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	bimodal	bimodal	ADJ	JJ	Degree=Pos	_	_	_	_
15	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gal	gal	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	some	some	DET	DT	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	no	no	DET	DT	_	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	gal	gal	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	others	other	NOUN	NNS	Number=Plur	_	_	_	_
32	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5343
# text = This expression pattern cannot be accounted for by cell-cycle position or heritable variation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
5	not	not	PART	RB	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	accounted	account	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
13	position	position	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	heritable	heritable	ADJ	JJ	Degree=Pos	_	_	_	_
16	variation	variation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5344
# text = Further results, in which beta-gal activity is correlated with NF-AT-binding activity, indicate that the concentration of NF-AT must exceed a critical threshold before transcription initiates.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gal	gal	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	AT	at	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	indicate	indicate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	at	PRON	WDT	PronType=Rel	_	_	_	_
28	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
29	exceed	exceed	VERB	VB	VerbForm=Inf	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
32	threshold	threshold	NOUN	NN	Number=Sing	_	_	_	_
33	before	before	ADP	IN	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	initiates	initiate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5345
# text = This threshold likely reflects the NF-AT concentration-dependent assembly of transcription complexes at the promoter.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	threshold	threshold	NOUN	NN	Number=Sing	_	_	_	_
3	likely	likely	ADV	RB	_	_	_	_	_
4	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
9	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5346
# text = Similar constructs controlled by NF-kappa B or the entire interleukin-2 enhancer show bimodal expression patterns during induction, suggesting that thresholds set by the concentration of transcription factors may be a common property of inducible genes.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
3	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	bimodal	bimodal	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	thresholds	threshold	NOUN	NNS	Number=Plur	_	_	_	_
26	set	set	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
37	property	property	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5347
# text = Document 003001294 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001294	003001294	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5348
# text = One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjogrens' syndrome.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
12	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	autoantigen	autoantigen	ADJ	JJ	Degree=Pos	_	_	_	_
16	La/SS	La/ss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
22	library	library	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
28	Sjogrens	Sjogrens	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
29	'	'	PART	POS	_	_	_	_	_
30	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5349
# text = A cDNA library was prepared from peripheral blood lymphocytes of an autoimmune patient with primary Sjogrens' syndrome.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	library	library	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
13	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	Sjogrens	sjogrens	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
17	'	'	PUNCT	''	_	_	_	_	_
18	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5350
# text = The cDNA library was screened with the patients own autoimmune serum being monospecific for the nuclear autoantigen La/SS-B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	library	library	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	screened	screen	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	own	own	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	monospecific	monospecific	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	autoantigen	autoantigen	NOUN	NN	Number=Sing	_	_	_	_
18	La/SS	La/ss	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5351
# text = Thereby an alternative type of La mRNA was identified that differed from the known La mRNA due to an exchange of the exon 1.
1	Thereby	thereby	ADV	RB	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	La	La	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	differed	differ	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	La	La	PROPN	NNP	Number=Sing	_	_	_	_
16	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
17	due	due	ADP	IN	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5352
# text = Sequencing of the genomic region between the exons 1 and 2 showed that the alternative 5'-end is a part of the intron.
1	Sequencing	Sequencing	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	end	end	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	part	part	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5353
# text = In addition, the presence of an alternative promoter site, which exists within the intron downstream of the exon 1, became evident.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
17	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	became	become	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5354
# text = In consequence, the alternative La mRNA is the result of a promoter switching combined with an alternative splicing mechanism.
1	In	in	ADP	IN	_	_	_	_	_
2	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
6	La	La	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	result	result	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	_
15	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
19	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
20	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5355
# text = In the intron, further transcription factor binding sites, including a NF-kappa B element, were identified leading to the suggestion that the expression of the gene encoding for the nuclear autoantigen La/SS-B alters in dependence on disease conditions.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	suggestion	suggestion	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	autoantigen	autoantigen	NOUN	NN	Number=Sing	_	_	_	_
36	La/SS	La/ss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
44	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5356
# text = Document 003001295 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001295	003001295	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5357
# text = The promoter and 5' flanking sequences controlling human B29 gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	'	'	PUNCT	``	_	_	_	_	_
6	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B29	b29	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5358
# text = The product of the B-cell-specific B29 gene (B29, Ig beta, CD79b) is essential for Ig-mediated B-cell activation via the B-cell antigen receptor complex (BCR) on human and murine B lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	product	product	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	B29	B29	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	B29	B29	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	CD79	CD79	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	Ig-	Ig-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	via	via	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	BCR	BCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	_
44	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5359
# text = To better understand the regulation of this pivotal gene, we have analyzed the human genomic DNA sequence upstream of the B29 ATG start codon for transcriptional control activity.
1	To	to	ADV	RB	_	_	_	_	_
2	better	better	ADV	RBR	Degree=Cmp	_	_	_	_
3	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	pivotal	pivotal	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	B29	B29	PROPN	NNP	Number=Sing	_	_	_	_
23	ATG	ATG	PROPN	NNP	Number=Sing	_	_	_	_
24	start	start	NOUN	NN	Number=Sing	_	_	_	_
25	codon	codon	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	control	control	NOUN	NN	Number=Sing	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5360
# text = The human B29 gene lacks either a TATA or a CAAT box and transcription is initiated at multiple sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	B29	b29	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	lacks	lack	NOUN	NNS	Number=Plur	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	CAAT	Caat	NOUN	NN	Number=Sing	_	_	_	_
12	box	box	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5361
# text = The minimal promoter of the human B29 gene is contained within a 193-bp region 5' of these multiple start sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	B29	b29	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	193	193	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	'	'	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
22	start	start	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5362
# text = This minimal promoter exhibits B-cell-specific activity and contains SP1, ETS, OCT, and IKAROS/LYF-1 transcription factor motifs.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	exhibits	exhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	SP1	SP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	ETS	Ets	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	OCT	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	IKAROS	IKAROS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	LYF	LYF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5363
# text = All these motifs are strikingly conserved in sequence and placement relative to the previously characterized murine B29 promoter.
1	All	all	DET	PDT	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	strikingly	strikingly	ADV	RB	_	_	_	_	_
6	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	placement	placement	NOUN	NN	Number=Sing	_	_	_	_
11	relative	relative	ADV	RB	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	previously	previously	ADV	RB	_	_	_	_	_
15	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
17	B29	B29	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5364
# text = Additional upstream gene segments dramatically affected B29 minimal promoter activity.
1	Additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
5	dramatically	dramatically	ADV	RB	_	_	_	_	_
6	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	B29	B29	NUM	CD	NumType=Card	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5365
# text = A newly identified motif called the B29 conserved sequence (BCS), found upstream of both human and murine B29 promoters, appears to stimulate B29 transcription through a novel mechanism.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	newly	newly	ADV	RB	_	_	_	_	_
3	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
4	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
5	called	call	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	B29	b29	PROPN	NNP	Number=Sing	_	_	_	_
8	conserved	conserve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	BCS	BCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
21	B29	B29	NUM	CD	NumType=Card	_	_	_	_
22	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	B29	B29	NUM	CD	NumType=Card	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	through	through	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
32	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5366
# text = A single BCS had little effect either on the minimal B29 promoter or on a heterologous promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
3	BCS	Bcs	PROPN	NNP	Number=Sing	_	_	_	_
4	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	either	either	CCONJ	CC	_	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
11	B29	b29	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5367
# text = Instead, the BCS stimulated transcription by counteracting 5' negative regulatory DNA sequences that block the activity of the B29 minimal promoter in its absence.
1	Instead	instead	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BCS	BCS	PROPN	NNPS	Number=Plur	_	_	_	_
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	counteracting	counteract	VERB	VBG	VerbForm=Ger	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	block	block	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	B29	B29	PROPN	NNP	Number=Sing	_	_	_	_
22	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	absence	absence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5368
# text = These findings indicate that B29 gene expression is controlled by the complex interplay of positive and negative regulatory elements.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	B29	B29	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
13	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5369
# text = Document 003001299 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001299	003001299	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5370
# text = Regulation of the tissue factor gene in human monocytic cells.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5371
# text = Role of AP-1, NF-kappa B/Rel, and Sp1 proteins in uninduced and lipopolysaccharide-induced expression.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5372
# text = Tissue factor (TF) expression by peripheral blood monocytes during sepsis initiates intravascular thrombosis.
1	Tissue	Tissue	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	sepsis	sepsis	ADJ	JJ	Degree=Pos	_	_	_	_
13	initiates	initiate	NOUN	NNS	Number=Plur	_	_	_	_
14	intravascular	intravascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	thrombosis	thrombosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5373
# text = Bacterial lipopolysaccharide (LPS) rapidly induces TF gene transcription in monocytes.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	rapidly	rapidly	ADV	RB	_	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	TF	Tf	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5374
# text = The human TF promoter contains binding sites for the transcription factors AP-1, c-Rel/p65, Egr-1, and Sp1. NF-kappa B/Rel proteins have been shown to physically interact with both AP-1 and Sp1 proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	Rel/p65	Rel/p65	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	physically	physically	ADV	RB	_	_	_	_	_
37	interact	interact	ADV	RB	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	both	both	DET	DT	_	_	_	_	_
40	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
45	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5375
# text = In this study, we investigated the role of these transcription factors in uninduced and LPS-induced TF gene expression in human monocytic THP-1 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5376
# text = Deletional analysis indicated that five Sp1 sites mediated basal expression in uninduced cells.
1	Deletional	Deletional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	five	five	NUM	CD	NumType=Card	_	_	_	_
6	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5377
# text = The two AP-1 sites bound c-Fos/c-Jun heterodimers in both unstimulated and LPS-stimulated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	bound	bound	ADP	IN	_	_	_	_	_
8	c-Fos/c	c-Fos/c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-Jun	-Jun	ADJ	JJ	Degree=Pos	_	_	_	_
10	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5378
# text = Maximal LPS induction of the TF promoter required the two AP-1 sites and the kappa B site within the LPS response element.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5379
# text = Disruption of the conserved spacing between the proximal AP-1 site and the kappa B site abolished LPS induction.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	spacing	spacing	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5380
# text = Replacement of the two AP-1 sites with intrinsically bent DNA partially restored LPS induction, suggesting an additional structural role for the AP-1 sites.
1	Replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	intrinsically	intrinsically	ADV	RB	_	_	_	_	_
11	bent	bent	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	partially	partially	ADV	RB	_	_	_	_	_
14	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
21	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5381
# text = Synergistic transactivation of the LPS response element in Drosophila Schneider cells by coexpression of c-Fos, c-Jun, c-Rel, and p65 or c-Jun and p65 required the transactivation domains of c-Jun and p65.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
10	Schneider	Schneider	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	p65	p65	NUM	CD	NumType=Card	_	_	_	_
33	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
36	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5382
# text = These data indicated that c-Fos/c-Jun, c-Rel/p65, and Sp1 regulate TF gene expression in human monocytic cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-Jun	-Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	c-Rel/p65	c-Rel/p65	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
12	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5383
# text = Document 003001303 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001303	003001303	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5384
# text = Nuclear factor-IL6 activates the human IL-4 promoter in T cells.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
5	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5385
# text = Positive regulatory element I (PRE-I) is a strong enhancer element essential for expression of the human IL-4 gene.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PRE	pre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5386
# text = To identify transcription factors binding to PRE-I, we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta).
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	PRE	pre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	screened	screen	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	cDNA	cDNA	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	library	library	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
25	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	also	also	ADV	RB	_	_	_	_	_
35	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
40	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5387
# text = NF-IL6 mRNA was found in human Jurkat T cells and in the mouse Th2 clone D10, but not in Th1 clone 29.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
16	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
17	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
18	D10	D10	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
24	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
25	29	29	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5388
# text = rNF-IL6 expressed in bacteria was shown to specifically bind to PRE-I.
1	rNF	rNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	specifically	specifically	ADV	RB	_	_	_	_	_
11	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	PRE	pre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5389
# text = PRE-I forms multiple DNA-protein complexes with nuclear extracts from Jurkat cells.
1	PRE	pre	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5390
# text = Some of these complexes were demonstrated to contain NF-IL6 by using anti-C/EBP beta Abs.
1	Some	some	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	anti-C	anti-C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
17	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
18	Abs	Abs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5391
# text = Overexpression of NF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the PRE-I-thymidine kinase or the human IL-4 promoter more than 10-fold in Jurkat cells.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
6	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
12	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
32	than	than	ADP	IN	_	_	_	_	_
33	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5392
# text = Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions -44 to -36 (C/EBP proximal) and -87 to -79 (C/EBP medial), respectively.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
15	-44	-44	NUM	CD	NumType=Card	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	-36	-36	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	_
21	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	87	87	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	-79	-79	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	C/	C/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
31	medial	medial	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5393
# text = Our results demonstrate that NF-IL6 is involved in transcriptional activation of the human IL-4 promoter in T cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5394
# text = Document 003001311 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001311	003001311	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5395
# text = An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	apparently	apparently	ADV	RB	_	_	_	_	_
11	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
18	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
19	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5396
# text = We have identified a DNA segment that confers responsiveness to antigen stimulation signals on the human interleukin (IL) 4 gene in Jurkat cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	confers	confer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	antigen	antigen	VERB	VB	VerbForm=Inf	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5397
# text = The human IL-4 gene, of 10 kilobases, is composed of four exons and three introns.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	four	four	NUM	CD	NumType=Card	_	_	_	_
16	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	three	three	NUM	CD	NumType=Card	_	_	_	_
19	introns	intron	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5398
# text = A cis-acting element (P sequence) resides in the 5' upstream region; no additional DNA segments with enhancer activity were identified in the human IL-4 gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	P	p	NOUN	NN	Number=Sing	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	resides	reside	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5399
# text = For further mapping purposes, a fusion promoter was constructed with the granulocyte/macrophage colony-stimulating factor basic promoter containing 60 base pairs of sequence upstream from the cap site of the mouse granulocyte/macrophage colony-stimulating factor gene and various lengths of the 5' upstream sequence of the IL-4 gene.
1	For	for	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
4	purposes	purpose	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
16	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	60	60	NUM	CD	NumType=Card	_	_	_	_
24	base	base	NOUN	NN	Number=Sing	_	_	_	_
25	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
28	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
36	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
39	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
46	lengths	length	NOUN	NNS	Number=Plur	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	'	's	PUNCT	``	_	_	_	_	_
51	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
52	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	4	4	NUM	CD	NumType=Card	_	_	_	_
58	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5400
# text = The P sequence was located between positions -79 and -69 relative to the transcription start site of the human IL-4 gene, and this location was confirmed by base-substitution mutations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	P	p	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	79	79	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	69	69	NUM	CD	NumType=Card	_	_	_	_
13	relative	relative	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	start	start	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	location	location	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
36	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5401
# text = The plasmids carrying multiple copies of the P sequence showed higher responsiveness to the stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
3	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	P	P	PROPN	NNP	Number=Sing	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
12	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5402
# text = The binding protein(s) that recognize the P sequence of the IL-4 gene were identified by DNA-mobility-shift assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	s	s	X	AFX	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	P	P	NOUN	NN	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5403
# text = The binding of NF(P) (a DNA binding protein that specifically recognizes the P sequence) to the P sequence was abolished when oligonucleotides carrying base substitutions were used, indicating that the NF(P) interaction is sequence-specific and that binding specificity of the protein paralleled the sequence requirements for IL-4 expression in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	specifically	specifically	ADV	RB	_	_	_	_	_
15	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	P	p	NOUN	NN	Number=Sing	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	when	when	ADV	WRB	PronType=Int	_	_	_	_
27	oligonucleotides	oligonucleotides	SCONJ	IN	_	_	_	_	_
28	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
29	base	base	NOUN	NN	Number=Sing	_	_	_	_
30	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	P	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	that	that	SCONJ	IN	_	_	_	_	_
48	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
49	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
53	paralleled	parallel	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
56	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
60	4	4	NUM	CD	NumType=Card	_	_	_	_
61	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5404
# text = The P sequence does not share homology with the 5' upstream sequence of the IL-2 gene, even though surrounding sequences of the IL-4 gene share high homology with the IL-2 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	P	p	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	share	share	VERB	VB	VerbForm=Inf	_	_	_	_
7	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	``	_	_	_	_	_
12	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	even	even	ADV	RB	_	_	_	_	_
22	though	though	SCONJ	IN	_	_	_	_	_
23	surrounding	surround	VERB	VBG	VerbForm=Ger	_	_	_	_
24	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	share	share	NOUN	NN	Number=Sing	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
33	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5405
# text = We conclude that a different set of proteins recognize IL-2 and IL-4 genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	set	set	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5406
# text = Document 003001312 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001312	003001312	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5407
# text = PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells.
1	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
3	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5408
# text = BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions.
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
4	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
18	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5409
# text = Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation.
1	Better	better	ADJ	JJ	Degree=Pos	_	_	_	_
2	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	ECs	EC	PROPN	NNP	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	plaque	plaque	NOUN	NN	Number=Sing	_	_	_	_
17	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5410
# text = Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives.
1	Peroxisome	Peroxisome	DET	DT	_	_	_	_	_
2	proliferator	proliferator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	member	member	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
27	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
28	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	fibric	fibric	ADJ	JJ	Degree=Pos	_	_	_	_
31	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
32	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5411
# text = The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5412
# text = METHODS AND RESULTS:
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 5413
# text = Immunohistochemistry revealed that human carotid artery ECs express PPARalpha.
1	Immunohistochemistry	Immunohistochemistry	PROPN	NNP	Number=Sing	_	_	_	_
2	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	carotid	carotid	NOUN	NN	Number=Sing	_	_	_	_
6	artery	artery	NOUN	NN	Number=Sing	_	_	_	_
7	ECs	Ecs	PROPN	NNP	Number=Sing	_	_	_	_
8	express	express	PROPN	NNP	Number=Sing	_	_	_	_
9	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5414
# text = Pretreatment of cultured human ECs with the PPARalpha activators fenofibrate or WY14643 inhibited TNF-alpha-induced VCAM-1 in a time- and concentration-dependent manner, an effect not seen with PPARgamma activators.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	_
9	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
10	fenofibrate	fenofibrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	WY	WY	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	14643	14643	NUM	CD	NumType=Card	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	_
39	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5415
# text = Both PPARalpha activators decreased cytokine-induced VCAM-1 mRNA expression without altering its mRNA half-life.
1	Both	both	DET	DT	_	_	_	_	_
2	PPARalpha	PPARalpha	NOUN	NN	Number=Sing	_	_	_	_
3	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
4	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	without	without	SCONJ	IN	_	_	_	_	_
14	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
16	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	life	life	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5416
# text = Transient transfection of deletional VCAM-1 promoter constructs and electrophoretic mobility shift assays suggest that fenofibrate inhibits VCAM-1 transcription in part by inhibiting NF-kappaB.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	deletional	deletional	ADJ	JJ	Degree=Pos	_	_	_	_
5	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
13	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
14	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
15	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	fenofibrate	fenofibrate	ADJ	JJ	Degree=Pos	_	_	_	_
18	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
19	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	part	part	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	SCONJ	IN	_	_	_	_	_
26	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5417
# text = Finally, PPARalpha activators significantly reduced adhesion of U937 cells to cultured human ECs.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
5	significantly	significantly	ADV	RB	_	_	_	_	_
6	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	U937	U937	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	ECs	EC	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5418
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 5419
# text = Human ECs express PPARalpha, a potentially important regulator of atherogenesis through its transcriptional control of VCAM-1 gene expression.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	potentially	potentially	ADV	RB	_	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5420
# text = Such findings also have implications regarding the clinical use of lipid-lowering agents, like fibric acids, which can activate PPARalpha.
1	Such	such	ADJ	JJ	Degree=Pos	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
6	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	use	use	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	lipid	lipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	lowering	lowering	VERB	VBG	VerbForm=Ger	_	_	_	_
14	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	like	like	ADP	IN	_	_	_	_	_
17	fibric	fibric	ADJ	JJ	Degree=Pos	_	_	_	_
18	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
23	PPARalpha	PPARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5421
# text = Document 003001318 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001318	003001318	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5422
# text = S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells.
1	S-	S-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	allyl	allyl	NOUN	NN	Number=Sing	_	_	_	_
3	cysteine	cysteine	PRON	PRP	_	_	_	_	_
4	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5423
# text = Reactive oxygen species are involved in signal transduction pathways leading to nuclear factor kappa B (NF-kappa B) activation which has been implicated in the regulation of gene transcription.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
3	species	species	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5424
# text = We recently reported that a garlic compound, S-allyl cysteine (SAC), protects bovine pulmonary artery endothelial cells from oxidant injury induced by hydrogen peroxide (H2O2).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	recently	recently	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	garlic	garlic	ADJ	JJ	Degree=Pos	_	_	_	_
7	compound	compound	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	S-	S-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	allyl	allyl	NOUN	NN	Number=Sing	_	_	_	_
11	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	SAC	SAC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	protects	protect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	bovine	bovine	PRON	PRP	_	_	_	_	_
18	pulmonary	pulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
19	artery	artery	NOUN	NN	Number=Sing	_	_	_	_
20	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
24	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	hydrogen	hydrogen	NOUN	NN	Number=Sing	_	_	_	_
28	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5425
# text = In this study we determined the effects of SAC on NF-kappa B activation in human T lymphocytes (Jurkat cells) induced by tumor necrosis factor alpha (TNF- alpha) and H2O2.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	SAC	SAC	PROPN	NNP	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
27	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5426
# text = Activated NF-kappa B in nuclear extracts was measured by an electrophoretic mobility shift assay using 32P-labeled probe.
1	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
14	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
15	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
16	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
17	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
18	32P	32p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5427
# text = SAC consistently exhibited a dose-dependent inhibition of NF-kappa B activation induced by both TNF-alpha and H2O2.
1	SAC	SAC	PROPN	NNP	Number=Sing	_	_	_	_
2	consistently	consistently	ADV	RB	_	_	_	_	_
3	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5428
# text = Supershift with specific antibodies to NF-kappa B subunits confirmed that the inducible retarded bands observed in the EMSA and p65-p50 heterodimer of the NF-kappa B/Rel protein.
1	Supershift	Supershift	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
15	retarded	retarded	ADJ	JJ	Degree=Pos	_	_	_	_
16	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
17	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
25	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5429
# text = Our data suggest that SAC may act via antioxidant mechanisms to block NF-kappa B activation in Jurkat cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	SAC	SAC	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
8	via	via	ADP	IN	_	_	_	_	_
9	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5430
# text = Document 003001332 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001332	003001332	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5431
# text = Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells [see comments] BOB.1/OBF.1 is a transcriptional coactivator that is constitutively expressed in B cells and interacts with the Oct1 and Oct2 transcription factors.
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
7	BOB.1/OBF	BOB.1/OBF	ADP	IN	_	_	_	_	SpaceAfter=No
8	.1	.1	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
14	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
16	BOB.1/OBF	BOB.1/OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.1	.1	NUM	CD	NumType=Card	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Oct1	oct1	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5432
# text = Upon activation of Jurkat T cells and primary murine thymocytes with phorbol esters and ionomycin, BOB.1/OBF.1 expression and transactivation function were induced.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	BOB.1/OBF	BOB.1/OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.1	.1	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
22	function	function	NOUN	NN	Number=Sing	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5433
# text = BOB.1/OBF.1 was phosphorylated at Ser184 both in vivo and in vitro, and this modification was required for inducible activation.
1	BOB.1/OBF	BOB.1/OBF	ADP	IN	_	_	_	_	SpaceAfter=No
2	.1	.1	NUM	CD	NumType=Card	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	Ser184	Ser184	PROPN	NNP	Number=Sing	_	_	_	_
7	both	both	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5434
# text = Mutation of Ser184 also diminished transactivation function in B cells, suggesting that the activating phosphorylation that is inducible in T cells is constitutively present in B cells.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Ser184	Ser184	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5435
# text = Thus, BOB.1/OBF.1 is a transcriptional coactivator that is critically regulated by posttranslational modifications to mediate cell type-specific gene expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	BOB.1/OBF	BOB.1/OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	.1	.1	NUM	CD	NumType=Card	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	critically	critically	ADV	RB	_	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	posttranslational	posttranslational	ADJ	JJ	Degree=Pos	_	_	_	_
15	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5436
# text = Document 003001341 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001341	003001341	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5437
# text = Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
7	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
13	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5438
# text = We have previously reported that the T lymphocytes of a child with severe combined immunodeficiency are defective in the transcription of several lymphokine genes that include IL2, IL3, IL4, and IL5, which encode interleukins 2, 3, 4, and 5 (IL-2, -3, -4, and -5).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	child	child	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
14	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
23	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	IL2	IL2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	IL4	IL4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	IL5	IL5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	encode	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	interleukins	interleukin	NOUN	NNS	Number=Plur	_	_	_	_
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	5	5	NUM	CD	NumType=Card	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
53	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
56	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
60	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5439
# text = To determine whether the defect in the patient's T lymphocytes involved a trans-acting factor common to the affected lymphokine genes, we examined the ability of nuclear factors from the patient's T lymphocytes to bind response elements present in the regulatory region of IL2.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	's	's	PART	POS	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	trans	trans	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	's	's	PART	POS	_	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	_
41	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
42	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
46	region	region	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	IL2	IL2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5440
# text = Nuclear factor NF-kB, activation protein 1 (AP-1), OCT-1, and NF-IL-2B binding activity were normal.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	OCT	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2B	2B	PROPN	NNP	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5441
# text = In contrast, the binding of the nuclear factor of activated T cells (NF-AT) to its response element in the IL2 enhancer and to an NF-AT-like response element present in the IL4 enhancer was abnormal.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL2	Il2	NOUN	NN	Number=Sing	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	element	element	NOUN	NN	Number=Sing	_	_	_	_
37	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	IL4	IL4	PROPN	NNP	Number=Sing	_	_	_	_
41	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5442
# text = To ascertain whether the abnormal NF-AT binding activity was related to an impaired function, we transfected patient and control T lymphocytes with constructs containing the reporter gene encoding chloramphenicol acetyl transferase (CAT) under the control of the entire IL2 regulatory region or of multimers of individual enhancer sequences.
1	To	to	PART	TO	_	_	_	_	_
2	ascertain	ascertain	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	AT	at	SCONJ	IN	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	impaired	impaired	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	control	control	NOUN	NN	Number=Sing	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
27	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
32	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
33	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
34	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	under	under	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	control	control	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
44	IL2	Il2	NUM	CD	NumType=Card	_	_	_	_
45	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
46	region	region	NOUN	NN	Number=Sing	_	_	_	_
47	or	or	CCONJ	CC	_	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	multimers	multimer	NOUN	NNS	Number=Plur	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
52	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
53	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5443
# text = CAT expression directed by the IL2 regulatory region or by a multimer of the NF-AT-binding site was markedly lower in the patient relative to controls.
1	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL2	Il2	NUM	CD	NumType=Card	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	multimer	multimer	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	AT	at	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	markedly	markedly	ADV	RB	_	_	_	_	_
23	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
27	relative	relative	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5444
# text = In contrast, CAT gene expression directed by a multimer of the OCT-1 proximal (OCT-1p)-binding site was equivalent in patient and controls.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	multimer	multimer	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	OCT	Oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	OCT	Oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5445
# text = These results indicate that an abnormality of/or influencing NF-AT may underlie the multiple lymphokine deficiency in this patient.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	abnormality	abnormality	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	or	or	CCONJ	CC	_	_	_	_	_
10	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
19	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5446
# text = Document 003001342 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001342	003001342	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5447
# text = Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
1	Oncogenic	Oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
2	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NOTCH1	Notch1	PROPN	NNP	Number=Sing	_	_	_	_
5	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	retain	retain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5448
# text = Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice.
1	Truncated	Truncated	ADJ	JJ	Degree=Pos	_	_	_	_
2	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NOTCH1	Notch1	PROPN	NNP	Number=Sing	_	_	_	_
6	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	engineered	engineer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	resemble	resemble	VERB	VB	VerbForm=Inf	_	_	_	_
11	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
12	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NOTCH1	Notch1	PROPN	NNP	Number=Sing	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
18	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	leukemia/	leukemiaith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	ALL	All	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	efficiently	efficiently	ADV	RB	_	_	_	_	_
31	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	ALL	all	ADV	RB	_	_	_	_	_
35	when	when	ADV	WRB	PronType=Int	_	_	_	_
36	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
40	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5449
# text = Unlike full-sized NOTCH1, two such truncated forms of the protein either lacking a major portion of the extracellular domain (DeltaE) or consisting only of the intracellular domain (ICN) were found to activate transcription in cultured cells, presumably through RBP-Jkappa response elements within DNA.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	sized	size	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NOTCH1	Notch1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
9	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
18	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	DeltaE	DeltaE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	consisting	consist	VERB	VBG	VerbForm=Ger	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	ICN	ICN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	presumably	presumably	ADV	RB	_	_	_	_	_
46	through	through	ADP	IN	_	_	_	_	_
47	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
50	response	response	NOUN	NN	Number=Sing	_	_	_	_
51	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
52	within	within	ADP	IN	_	_	_	_	_
53	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5450
# text = Both truncated forms also bound to the transcription factor RBP-Jkappa in extracts prepared from human and murine T-ALL cell lines.
1	Both	both	DET	DT	_	_	_	_	_
2	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
15	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	human	human	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	ALL	all	DET	DT	_	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5451
# text = Transcriptional activation required the presence of a weak RBP-Jkappa-binding site within the NOTCH1 ankyrin repeat region of the intracellular domain.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
9	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NOTCH1	Notch1	NOUN	NN	Number=Sing	_	_	_	_
18	ankyrin	ankyrin	ADP	IN	_	_	_	_	_
19	repeat	repeat	ADJ	JJ	Degree=Pos	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5452
# text = Unexpectedly, a second, stronger RBP-Jkappa-binding site, which lies within the intracellular domain close to the transmembrane region and significantly augments association with RBP-Jkappa, was not needed for oncogenesis or for transcriptional activation.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
7	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	significantly	significantly	ADV	RB	_	_	_	_	_
27	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
28	association	association	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	oncogenesis	oncogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5453
# text = While ICN appeared primarily in the nucleus, DeltaE localized to cytoplasmic and nuclear membranes, suggesting that intranuclear localization is not essential for oncogenesis or transcriptional activation.
1	While	while	SCONJ	IN	_	_	_	_	_
2	ICN	ICN	PROPN	NNP	Number=Sing	_	_	_	_
3	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	primarily	primarily	ADV	RB	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	DeltaE	DeltaE	PROPN	NNP	Number=Sing	_	_	_	_
10	localized	localize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	intranuclear	intranuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	oncogenesis	oncogenesis	ADJ	JJ	Degree=Pos	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5454
# text = In support of this interpretation, mutation of putative nuclear localization sequences decreased nuclear localization and increased transcriptional activation by membrane-bound DeltaE.
1	In	in	ADP	IN	_	_	_	_	_
2	support	support	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interpretation	interpretation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
12	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
24	DeltaE	Delta	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5455
# text = Transcriptional activation by this mutant form of membrane-bound DeltaE was approximately equivalent to that produced by intranuclear ICN.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
11	DeltaE	DeltaE	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	approximately	approximately	ADV	RB	_	_	_	_	_
14	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
17	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	intranuclear	intranuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	ICN	Icn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5456
# text = These data are most consistent with NOTCH1 oncogenesis and transcriptional activation being independent of association with RBP-Jkappa at promoter sites.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	most	most	ADV	RBS	_	_	_	_	_
5	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	NOTCH1	Notch1	PROPN	NNP	Number=Sing	_	_	_	_
8	oncogenesis	oncogenesis	PROPN	NNPS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	association	association	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Jkappa	Jkappa	PROPN	NNP	Number=Sing	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5457
# text = Document 003001344 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001344	003001344	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5458
# text = Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging.
1	Impaired	Impaired	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	fos/c-jun	fos/c-jun	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	c-fos/c-jun	c-fos/c-jun	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5459
# text = The activation of transcriptional factor c-Fos/c-Jun AP-1 is essential for normal T cell responsiveness and is often impaired in T cells during aging.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-Jun	-Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	often	often	ADV	RB	_	_	_	_	_
21	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5460
# text = In the present study, we investigated whether aberrancies in the regulation of c-fos/c-jun at the mRNA or protein level might underlie the age-associated impairments of AP-1 in human T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	whether	whether	SCONJ	IN	_	_	_	_	_
9	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	fos/c-jun	fos/c-jun	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
23	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	age-	age-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	T	T	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5461
# text = Whereas T cells from young subjects stimulated with cross-linked anti-CD3epsilon mAb OKT3 plus PMA or with the lectin PHA plus PMA demonstrated considerable increases in c-Fos protein expression, the expression of c-Fos but not c-Jun was markedly reduced in stimulated T cells from certain elderly subjects.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
6	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
13	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
14	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	_
15	plus	plus	CCONJ	CC	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lectin	lectin	PROPN	NNP	Number=Sing	_	_	_	_
21	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
22	plus	plus	CCONJ	CC	_	_	_	_	_
23	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
24	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
26	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	not	not	ADV	RB	_	_	_	_	_
42	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
43	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	markedly	markedly	ADV	RB	_	_	_	_	_
46	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	from	from	ADP	IN	_	_	_	_	_
52	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
53	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
54	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5462
# text = In addition,
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 5463
# text = RNase protection assays revealed that anti-CD3/PMA-stimulated T cells from a substantial proportion of elderly subjects exhibited decreased levels of c-fos and/or c-jun mRNA compared to T cells from young subjects.
1	RNase	RNase	NOUN	NN	Number=Sing	_	_	_	_
2	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	anti-CD3/PMA	anti-CD3/PMa	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
14	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
17	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
18	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	or	or	CCONJ	CC	_	_	_	_	_
28	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
30	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
31	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
37	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5464
# text = Using electrophoretic mobility shift assays, the levels of nuclear regulatory proteins recognizing the AP-1 consensus TRE motif, the proximal c-jun TRE-like promoter element, and the c-fos serum response element (SRE) were determined in resting and stimulated T cells.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	recognizing	recognize	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
20	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
24	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	jun	jun	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	TRE	Tre	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
37	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
38	response	response	NOUN	NN	Number=Sing	_	_	_	_
39	element	element	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5465
# text = Although the stimulation of T cells from young subjects resulted in coordinated increases of nuclear protein complexes binding the AP-1 TRE, c-jun TRE, and c-fos SRE DNA sequence motifs, age-related reductions in the activation of AP-1 were accompanied by decreased levels of c-jun TRE and c-fos SRE binding complexes.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
9	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
10	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
27	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
32	SRE	Sre	ADJ	JJ	Degree=Pos	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
35	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
40	reductions	reduction	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
55	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
56	TRE	tre	NOUN	NN	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
59	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
60	SRE	Sre	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
61	binding	binding	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
62	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5466
# text = Furthermore, the nuclear protein complexes binding the SRE motif induced in activated T cells of young and elderly subjects contained serum response factor and Elk-1 pointing toward age-related defects in the activation of transcriptional regulatory proteins distinct from c-jun/AP-1.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
20	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
21	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Elk	elk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	pointing	point	VERB	VBG	VerbForm=Ger	_	_	_	_
30	toward	toward	ADP	IN	_	_	_	_	_
31	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
34	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
40	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
41	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
42	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
43	from	from	ADP	IN	_	_	_	_	_
44	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
45	jun/AP	jun/AP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5467
# text = These results suggest that underlying aberrancies in the induction of c-fos/c-jun as well as their nuclear regulatory proteins may contribute to the age-related impairments of AP-1 activation in human T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
6	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	fos/c-jun	fos/c-jun	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
27	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5468
# text = Document 003001359 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001359	003001359	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5469
# text = Effects of alpha-lipoic acid and dihydrolipoic acid on expression of proto-oncogene c-fos.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
6	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	dihydrolipoic	dihydrolipoic	ADJ	JJ	Degree=Pos	_	_	_	_
9	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
16	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5470
# text = The transcription factor AP-1 is an important human mediator of the cellular response to serum, growth factors, and phorbol esters such as 12-O-tetradecanoyl-phorbol-13 acetate (TPA).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
24	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
30	-tetradecanoyl-phorbol-13	-tetradecanoyl-phorbol-13	NUM	CD	NumType=Card	_	_	_	_
31	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5471
# text = The AP-1 complex consists of distinct protein heterodimers encoded by the proto-oncogene c-fos and c-jun mRNA whose gene expression can be induced by TPA, cyclic AMP and growth factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
11	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
16	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
32	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5472
# text = Recent findings suggest an involvement of reactive oxygen species in the pathway of TPA and protein kinase C leading to expression of c-fos and c-jun mRNA.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
8	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
9	species	species	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	C	c	PROPN	NNP	Number=Sing	_	_	_	_
19	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
29	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5473
# text = To investigate the role of reactive oxygen species we studied the effects of alpha-lipoic acid and dihydrolipoic acid (natural thiol antioxidants) on the expression of c-fos mRNA in human Jurkat T cells.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
7	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
8	species	species	NOUN	NNS	Number=Plur	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
17	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	dihydrolipoic	dihydrolipoic	ADJ	JJ	Degree=Pos	_	_	_	_
20	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
23	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	_
24	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
33	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5474
# text = When cells were preincubated with dihydrolipoic acid (0.2 mM) the expression of c-fos mRNA was suppressed at 30 min after stimulation of TPA (0.5 microM) whereas in the case of preincubation of alpha-lipoic acid (0.2 microM), the expression was enhanced at 30 min.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	dihydrolipoic	dihydrolipoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
10	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
18	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	30	30	NUM	CD	NumType=Card	_	_	_	_
23	min	min	NOUN	NNS	Number=Plur	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
30	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	case	case	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
42	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
45	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
50	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
51	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	at	at	ADP	IN	_	_	_	_	_
53	30	30	NUM	CD	NumType=Card	_	_	_	_
54	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5475
# text = These studies support the idea that superoxide anion radical plays a role in the expression of c-fos mRNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	idea	idea	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	superoxide	superoxide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	anion	anion	NOUN	NN	Number=Sing	_	_	_	_
9	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
10	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
20	mRNA.	mRNA.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5476
# text = Document 003001363 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001363	003001363	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5477
# text = SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity.
1	SLP	Slp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-76	-76	NUM	CD	NumType=Card	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	overlapping	overlapp	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	augment	augment	NOUN	NN	Number=Sing	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5478
# text = SLP-76 and Vav, two hematopoietic cell specific molecules, are critical for T cell development and activation.
1	SLP	Slp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-76	-76	NUM	CD	NumType=Card	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	development	development	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5479
# text = Following
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 5480
# text = T cell antigen receptor stimulation, SLP-76 and Vav both undergo tyrosine phosphorylation and associate with each other via the SH2 domain of Vav and phosphorylated tyrosines of SLP-76.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	76	76	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	undergo	undergo	ADJ	JJ	Degree=Pos	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	associate	associate	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	each	each	DET	DT	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	tyrosines	tyrosine	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	76	76	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5481
# text = Furthermore, SLP-76 and Vav have a synergistic effect on interleukin (IL)-2 promoter activity in T cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	76	76	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
8	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5482
# text = In this report, we show that two tyrosines, Tyr-113 and Tyr-128, of SLP-76 are required for its binding to Vav, both in vitro and in intact cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	tyrosines	tyrosine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Tyr	Tyr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	113	113	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Tyr	Tyr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-128	-128	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	SLP	sLp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	76	76	NUM	CD	NumType=Card	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	for	for	SCONJ	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5483
# text = Surprisingly, we find also that the interaction between SLP-76 and Vav is not required for their cooperation in augmenting IL-2 promoter activity, as the two molecules appear to function in different signaling pathways upstream of IL-2 gene expression.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	76	76	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
33	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
38	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
39	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
40	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5484
# text = Overexpression of SLP-76 in the Jurkat T cell line potentiates the activities of both nuclear factor of activated T cells and AP-1 transcription factors.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	76	76	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5485
# text = In contrast, overexpression of Vav leads to enhanced nuclear factor of activated T cells activity without affecting AP-1.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
7	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	without	without	SCONJ	IN	_	_	_	_	_
18	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5486
# text = Additionally, overexpression of Vav, but not SLP-76, augments CD28-induced IL-2 promoter activity.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	SLP	sLp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	76	76	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
14	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5487
# text = These findings suggest that the synergy between SLP-76 and Vav in regulating IL-2 gene expression reflects the cooperation between different signaling pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	76	76	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
26	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5488
# text = Document 003001365 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001365	003001365	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5489
# text = Human immunodeficiency virus type-2 gene expression: two enhancers and their activation by T-cell activators.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5490
# text = The human immunodeficiency viruses (HIVs) may include a spectrum of retroviruses with varying potential to infect their host, undergo long periods of latent infection, and induce pathology.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HIVs	HIV	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	varying	vary	NOUN	NN	Number=Sing	_	_	_	_
16	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	undergo	undergo	ADV	RB	_	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
24	periods	periods	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
31	pathology	pathology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5491
# text = Since expression of the viruses is in large part regulated by the sequence elements in their long terminal repeats (LTRs), this study was directed to an analysis of the regulatory elements in the HIV-2 LTR.
1	Since	since	ADP	IN	_	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
9	part	part	NOUN	NN	Number=Sing	_	_	_	_
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	study	study	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
34	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5492
# text = The HIV-2 LTR was found to contain two enhancers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5493
# text = One of these enhancers is, in part, identical to the HIV-1 enhancer.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5494
# text = This enhancer in HIV-1 is the T-cell activation response element; in HIV-2, however, it is the second enhancer that is mainly responsible for activation in response to T-cell activators.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	mainly	mainly	ADV	RB	_	_	_	_	_
30	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5495
# text = The second enhancer interacts with two nuclear binding proteins (85 kD and 27 kD mobility) that appear to be required for optimal enhancer function and activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	85	85	NUM	CD	NumType=Card	_	_	_	_
12	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	27	27	NUM	CD	NumType=Card	_	_	_	_
15	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
16	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5496
# text = Observations such as these encourage the speculation that there may be subtle differences in the regulation of HIV-1 and HIV-2 expression that may be relevant to the possible longer latency and reduced pathogenicity of HIV-2.
1	Observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	as	as	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	encourage	encourage	NOUN	NN	Number=Sing	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	speculation	speculation	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	there	there	PRON	EX	_	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	VERB	VB	VerbForm=Inf	_	_	_	_
12	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
33	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
34	latency	latency	ADV	RB	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	pathogenicity	pathogenicity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5497
# text = Document 003001371 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001371	003001371	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5498
# text = Engagement of the Lewis X antigen (CD15) results in monocyte activation.
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Lewis	Lewis	PROPN	NNP	Number=Sing	_	_	_	_
5	X	X	PROPN	NNP	Number=Sing	_	_	_	_
6	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CD15	CD15	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5499
# text = We previously reported that monocyte adhesion to tumor necrosis factor-alpha (TNF-alpha)-treated endothelial cells increased expression of tissue factor and CD36 on monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5500
# text = Using immunological cross-linking to mimic receptor engagement by natural ligands, we now show that CD15 (Lewis X), a monocyte counter-receptor for endothelial selectins may participate in this response.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
3	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
11	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	now	now	ADV	RB	_	_	_	_	_
15	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	15	15	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	Lewis	Lewis	PROPN	NNP	Number=Sing	_	_	_	_
21	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
26	counter	counter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
31	selectins	selectin	NOUN	NNS	Number=Plur	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
36	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5501
# text = We used cytokine production as a readout for monocyte activation and found that CD15 cross-linking induced TNF-alpha release from peripheral blood monocytes and cells from the monocytic cell line MM6.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	readout	readout	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	15	15	NUM	CD	NumType=Card	_	_	_	_
16	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	release	release	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	_
34	MM6	Mm6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5502
# text = Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed an increase in steady-state TNF-alpha mRNA after 3 to 4 hours of cross-linking.
1	Quantitative	Quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
2	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
3	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
6	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
7	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RT-PCR	RT-PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	state	state	NOUN	NN	Number=Sing	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	after	after	ADP	IN	_	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5503
# text = CD15 cross-linking also concomitantly increased interleukin-1 beta (IL-1 beta) mRNA, while no apparent change was observed in the levels of beta-actin mRNA, indicating specificity.
1	CD15	CD15	NOUN	NN	Number=Sing	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	concomitantly	concomitantly	ADV	RB	_	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	no	no	DET	DT	_	_	_	_	_
21	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
22	change	change	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	actin	actin	NOUN	NN	Number=Sing	_	_	_	_
32	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
35	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5504
# text = To examine transcriptional regulation of cytokine genes by CD15 engagement, a CAT plasmid reporter construct containing IL-1 beta promoter/enhancer sequences was introduced into MM6.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	15	15	NUM	CD	NumType=Card	_	_	_	_
11	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
15	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	MM6	Mm6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5505
# text = Subsequent cross-linking of CD15 increased CAT activity.
1	Subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CD15	CD15	PROPN	NNP	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5506
# text = CD15 engagement by monoclonal antibody also attenuated IL-1 beta transcript degradation, demonstrating that signaling via CD15 also had posttranscriptional effects.
1	CD15	CD15	NUM	CD	NumType=Card	_	_	_	_
2	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
13	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	15	15	NUM	CD	NumType=Card	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5507
# text = Nuclear extracts of anti-CD15 cross-linked cells demonstrated enhanced levels of the transcriptional factor activator protein-1, minimally changed nuclear factor-kappa B, and did not affect SV40 promoter specific protein-1.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anti-CD15	anti-CD15	NUM	CD	NumType=Card	_	_	_	_
5	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	minimally	minimally	ADV	RB	_	_	_	_	_
21	changed	change	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
32	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5508
# text = We conclude that engagement of CD15 on monocytes results in monocyte activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CD15	CD15	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5509
# text = In addition to its well-recognized adhesive role, CD15 may function as an important signaling molecule capable of initiating proinflammatory events in monocytes that come into contact with activated endothelium.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	15	15	NUM	CD	NumType=Card	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
20	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
21	of	of	SCONJ	IN	_	_	_	_	_
22	initiating	initiat	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	come	come	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5510
# text = Document 003001372 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001372	003001372	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5511
# text = Vitamin
1	Vitamin	Vitamin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5512
# text = E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding.
1	E	e	NOUN	NN	Number=Sing	_	_	_	_
2	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
5	CCl4	CCl4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	hepatic	hepatic	ADJ	JJ	Degree=Pos	_	_	_	_
9	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5513
# text = Oxidative stress, with reactive oxygen intermediate formation, may represent a common mechanism by which liver injury is induced by diverse etiologies.
1	Oxidative	Oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
2	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
7	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
8	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
14	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	which	which	DET	WDT	PronType=Int	_	_	_	_
17	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
18	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
23	etiologies	etiology	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5514
# text = Oxidative stress enhances nuclear factor kappa B (NF-kappa B) activity, and NF-kappa B activity has been shown to enhance the expression of cytotoxic cytokines.
1	Oxidative	Oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
2	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
3	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5515
# text = Acute hepatic injury caused by reactive oxygen intermediate production was induced by an intraperitoneal injection of CCl4 in mice.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	hepatic	hepatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
4	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
7	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
8	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	intraperitoneal	intraperitoneal	ADJ	JJ	Degree=Pos	_	_	_	_
15	injection	injection	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CCl4	Ccl4	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5516
# text = This injury was significantly inhibited by intravenous pretreatment of the mice with a water-soluble emulsion of alpha-tocopherol.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	intravenous	intravenous	ADJ	JJ	Degree=Pos	_	_	_	_
8	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	water	water	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
17	emulsion	emulsion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5517
# text = Alpha-tocopherol treatment of the mice given the CCl4 also reduced the NF-kappa B binding to levels approaching those found in normal mice.
1	Alpha	Alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CCl4	CCl4	PROPN	NNP	Number=Sing	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	approaching	approach	VERB	VBG	VerbForm=Ger	_	_	_	_
22	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5518
# text = In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced NF-kappa B binding and an increase in tumor necrosis factor-alpha (TNF-alpha) messenger RNA levels.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CCl4	CCl4	PROPN	NNP	Number=Sing	_	_	_	_
13	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
36	RNA	RNA	ADP	IN	_	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5519
# text = Liver specimens taken from patients with acute fulminant hepatitis had markedly increased NF-kappa B binding activity in comparison with the binding of normal livers.
1	Liver	liver	PROPN	NNP	Number=Sing	_	_	_	_
2	specimens	specimen	NOUN	NNS	Number=Plur	_	_	_	_
3	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
8	fulminant	fulminant	ADJ	JJ	Degree=Pos	_	_	_	_
9	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
10	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	markedly	markedly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	livers	liver	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5520
# text = These data demonstrate that abolishing acute hepatic injury with alpha-tocopherol, a free radical scavenger, also eliminated increased NF-kappa B binding.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	abolishing	abolish	VERB	VBG	VerbForm=Ger	_	_	_	_
6	acute	acute	ADV	RB	_	_	_	_	_
7	hepatic	hepatic	ADJ	JJ	Degree=Pos	_	_	_	_
8	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
16	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
17	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	eliminated	eliminate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5521
# text = It is tempting to speculate that enhanced NF-kappa B expression caused by free radical production/oxidative stress may modulate liver injury, perhaps through an effect on cytotoxic cytokine synthesis.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	tempting	tempt	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	speculate	speculate	VERB	VB	VerbForm=Inf	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
16	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
20	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
24	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	perhaps	perhaps	ADV	RB	_	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5522
# text = Document 003001380 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001380	003001380	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5523
# text = Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.
1	Fludarabine	Fludarabine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5524
# text = Fludarabine is a nucleoside analog used in the treatment of hematologic malignancies that can induce severe and prolonged immunosuppression.
1	Fludarabine	Fludarabine	PRON	PRP	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	nucleoside	nucleoside	ADJ	JJ	Degree=Pos	_	_	_	_
5	analog	analog	NOUN	NN	Number=Sing	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	hematologic	hematologic	ADJ	JJ	Degree=Pos	_	_	_	_
12	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
16	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5525
# text = Although it can be incorporated into the DNA of dividing cells, fludarabine is also a potent inhibitor of cells with a low growth fraction, thus it must have other mechanisms of action.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	incorporated	incorporate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	dividing	dividing	VERB	VBG	VerbForm=Ger	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	fludarabine	fludarabine	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
24	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
25	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	thus	thus	ADV	RB	_	_	_	_	_
28	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
29	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
30	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
31	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
32	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5526
# text = STAT1, which is activated in response to many lymphocyte-activating cytokines including the interferons, is essential for cell-mediated immunity, as the absence of this protein is associated with prominent defects in the ability to control viral infections.
1	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
36	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
42	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
43	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5527
# text = Here we show that fludarabine, but not the immunosuppressant cyclosporine A, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	fludarabine	fludarabine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
11	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
30	resting	resting	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5528
# text = Fludarabine caused a specific depletion of STAT1 protein (and mRNA) but not of other STATs.
1	Fludarabine	Fludarabine	PROPN	NNP	Number=Sing	_	_	_	_
2	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	and	and	CCONJ	CC	_	_	_	_	_
11	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	STATs	STAT	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5529
# text = This loss of STAT1 was also seen in cells from patients treated with fludarabine in vivo.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	fludarabine	fludarabine	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5530
# text = Brief exposure to fludarabine led to a sustained loss of STAT1, analogous to the prolonged period of immunosuppression induced by exposure to the drug in vivo.
1	Brief	brief	ADJ	JJ	Degree=Pos	_	_	_	_
2	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	fludarabine	fludarabine	VERB	VB	VerbForm=Inf	_	_	_	_
5	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	analogous	analogous	CCONJ	CC	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	period	period	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5531
# text = Thus, STAT1 may be a useful target in the development of new immunosuppressive and antineoplastic agents.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
8	target	target	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	development	development	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
14	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	antineoplastic	antineoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
17	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5532
# text = Document 003001385 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001385	003001385	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5533
# text = Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	rheumatic	rheumatic	ADJ	JJ	Degree=Pos	_	_	_	_
14	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	preliminary	preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
18	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5534
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 5535
# text = The NF-kappa B/Rel family of transcription factors regulates the expression of many genes involved in the immune or inflammatory response at the transcriptional level.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5536
# text = The aim of this study was to determine whether distinctive patterns of NF-kappa B activation are seen in different forms of joint disease.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
9	whether	whether	SCONJ	IN	_	_	_	_	_
10	distinctive	distinctive	ADJ	JJ	Degree=Pos	_	_	_	_
11	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	joint	joint	ADJ	JJ	Degree=Pos	_	_	_	_
25	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5537
# text = METHODS: The DNA binding activity of these nucleoproteins was examined in purified synovial and peripheral T cells from patients with various chronic rheumatic diseases (12: four with rheumatoid arthritis; five with spondyloarthropathies; and three with osteoarthritis).
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	nucleoproteins	nucleoprotein	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
24	rheumatic	rheumatic	ADJ	JJ	Degree=Pos	_	_	_	_
25	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	:	:	PUNCT	:	_	_	_	_	_
29	four	four	NUM	CD	NumType=Card	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	;	;	PUNCT	,	_	_	_	_	_
34	five	five	NUM	CD	NumType=Card	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	spondyloarthropathies	spondyloarthropathy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	three	three	NUM	CD	NumType=Card	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	osteoarthritis	osteoarthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5538
# text = RESULTS: Electrophoretic mobility shift assays disclosed two specific complexes bound to a NF-kappa B specific 32P-labelled oligonucleotide in nucleoproteins extracted from purified T cells isolated from synovial fluid and peripheral blood of patients with rheumatoid arthritis.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assays	ADV	RB	_	_	_	_	_
7	disclosed	disclose	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
11	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	32P-	32p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	labelled	label	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	nucleoproteins	nucleoprotein	NOUN	NNS	Number=Plur	_	_	_	_
24	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
32	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
35	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
40	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5539
# text = The complexes consisted of p50/p50 homodimers and p50/p65 heterodimers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	consisted	consist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
7	p50	p50	NUM	CD	NumType=Card	_	_	_	_
8	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	p65	p65	NUM	CD	NumType=Card	_	_	_	_
13	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5540
# text = Increased NF-kappa B binding to DNA in synovial T cells was observed relative to peripheral T cells.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	b	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	relative	relative	ADV	RB	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5541
# text = In non-rheumatoid arthritis, binding of NF-kappa B in synovial T cells was exclusively mediated by p50/p50 homodimers.
1	In	in	ADP	IN	_	_	_	_	_
2	non-rheumatoid	non-rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	exclusively	exclusively	ADV	RB	_	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
21	p50	p50	NUM	CD	NumType=Card	_	_	_	_
22	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5542
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 5543
# text = Overall, the results suggest that NF-kappa B may play a central part in the activation of infiltrating T cells in chronic rheumatoid arthritis.
1	Overall	overall	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
15	part	part	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	infiltrating	infiltrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
25	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5544
# text = The activation of this nuclear factor is qualitatively different in rheumatoid synovial T cells to that in other forms of non-rheumatoid arthritis (for example, osteoarthritis, spondyloarthropathies).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	qualitatively	qualitatively	ADV	RB	_	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	non-rheumatoid	non-rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	for	for	ADP	IN	_	_	_	_	_
25	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	osteoarthritis	osteoarthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	spondyloarthropathies	spondyloarthropathy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5545
# text = Document 003001386 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001386	003001386	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5546
# text = Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-gamma activation site-like sequence upstream of the I epsilon exon in a human B cell line.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
6	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
31	epsilon	epsilon	X	FW	Foreign=Yes	_	_	_	_
32	exon	exon	X	FW	Foreign=Yes	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5547
# text = Evidence for the involvement of Janus kinase 3 and interleukin-4 Stat.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5548
# text = Germ line C transcripts can be induced by IL-4 in the human B cell line, BL-2.
1	Germ	Germ	ADJ	JJ	Degree=Pos	_	_	_	_
2	line	line	NOUN	NN	Number=Sing	_	_	_	_
3	C	c	NOUN	NN	Number=Sing	_	_	_	_
4	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	BL	BL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5549
# text = Utilizing a IFN-gamma activation site-like DNA sequence element located upstream of the I epsilon exon, we demonstrated by gel mobility shift assays that IL-4 induced a binding activity in the cytosol and nucleus of BL-2 cells.
1	Utilizing	Utilize	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	I	I	PROPN	NNP	Number=Sing	_	_	_	_
18	epsilon	epsilon	ADP	IN	_	_	_	_	_
19	exon	exon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	_
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5550
# text = This factor was designated IL-4 NAF (IL-4-induced nuclear-activating factors) and was identified as a tyrosine phosphoprotein, which translocates from the cytosol to the nucleus upon IL-4 treatment.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	NAF	Naf	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
26	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	translocates	translocate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
36	upon	upon	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	4	4	NUM	CD	NumType=Card	_	_	_	_
40	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5551
# text = Because these are the characteristics of a signal transducer and activator of transcription (Stat) protein, we determined whether antibodies to Stat proteins will interfere with gel mobility shift and found that antibodies to IL-4 Stat, also known as Stat6, but not antibodies to other Stat proteins, interfere with the formation of the IL-4 NAF complex.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	whether	whether	SCONJ	IN	_	_	_	_	_
22	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
27	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
30	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
31	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	4	4	NUM	CD	NumType=Card	_	_	_	_
40	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	also	also	ADV	RB	_	_	_	_	_
43	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	as	as	ADP	IN	_	_	_	_	_
45	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	but	but	CCONJ	CC	_	_	_	_	_
48	not	not	ADV	RB	_	_	_	_	_
49	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
52	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
53	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	interfere	interfere	ADV	RB	PronType=Dem	_	_	_	_
56	with	with	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
59	of	of	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	4	4	NUM	CD	NumType=Card	_	_	_	_
64	NAF	Naf	PROPN	NNP	Number=Sing	_	_	_	_
65	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5552
# text = Congruous with the involvement of a Stat protein, IL-4 induced robust Janus kinase 3 (JAK3) activity in BL-2 cells.
1	Congruous	Congruous	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	robust	robust	ADJ	JJ	Degree=Pos	_	_	_	_
15	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	3	3	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5553
# text = Cotransfection of JAK3 with IL-4
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 5554
# text = Stat into COS-7 cells produced an intracellular activity which bound the same IFN-gamma activation site-like sequence and comigrated with IL-4 NAF in electrophoretic mobility shift assay.
1	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
2	into	into	ADP	IN	_	_	_	_	_
3	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	7	7	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
15	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	comigrated	comigrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	4	4	NUM	CD	NumType=Card	_	_	_	_
29	NAF	Naf	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
33	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
34	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5555
# text = These results show that IL-4 NAF is IL-4 Stat, which is activated by JAK3 in response to IL-4 receptor engagement.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	NAF	Naf	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5556
# text = Document 003001387 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001387	003001387	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5557
# text = Limited proteolysis for assaying ligand binding affinities of nuclear receptors.
1	Limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	SCONJ	IN	_	_	_	_	_
4	assaying	assay	VERB	VBG	VerbForm=Ger	_	_	_	_
5	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5558
# text = The binding of natural or synthetic ligands to nuclear receptors is the triggering event leading to gene transcription activation or repression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
14	event	event	NOUN	NN	Number=Sing	_	_	_	_
15	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5559
# text = Ligand binding to the ligand binding domain of these receptors induces conformational changes that are evidenced by an increased resistance of this domain to proteases.
1	Ligand	Ligand	PROPN	NNP	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
12	conformational	conformational	ADJ	JJ	Degree=Pos	_	_	_	_
13	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5560
# text = In vitro labeled receptors were incubated with various synthetic or natural agonists or antagonists and submitted to trypsin digestion.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
3	labeled	label	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
12	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	submitted	submit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	trypsin	trypsin	VERB	VB	VerbForm=Inf	_	_	_	_
19	digestion	digestion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5561
# text = Proteolysis products were separated by SDS-PAGE and quantified.
1	Proteolysis	Proteolysis	PROPN	NNP	Number=Sing	_	_	_	_
2	products	product	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	SDS	SDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	PAGE	page	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	quantified	quantify	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5562
# text = The amount of trypsin-resistant fragments was proportional to receptor occupancy by the ligand, and allowed the determination of dissociation constants (kDa).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	trypsin-	trypsin-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
6	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	proportional	proportional	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	receptor	receptor	VERB	VB	VerbForm=Inf	_	_	_	_
11	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
22	constants	constant	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5563
# text = Using the wild-type or mutated human retinoic acid receptor alpha as a model, kDa values determined by classical competition binding assays using tritiated ligands are in agreement with those measured by the proteolytic assay.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
18	values	value	NOUN	NNS	Number=Plur	_	_	_	_
19	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
22	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	tritiated	tritiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
33	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5564
# text = This method was successfully extended to human retinoic X receptor alpha, glucocorticoid receptor, and progesterone receptor, thus providing a basis for a new, faster assay to determine simultaneously the affinity and conformation of receptors when bound to a given ligand.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	method	method	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	successfully	successfully	ADV	RB	_	_	_	_	_
5	extended	extend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	retinoic	retinoic	NOUN	NN	Number=Sing	_	_	_	_
9	X	x	SYM	SYM	_	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	thus	thus	ADV	RB	_	_	_	_	_
21	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	faster	faster	ADJ	JJR	Degree=Cmp	_	_	_	_
29	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
32	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	conformation	conformation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
39	when	when	ADV	WRB	PronType=Int	_	_	_	_
40	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5565
# text = Document 003001393 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001393	003001393	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5566
# text = Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa
1	Isolation	Isolation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
5	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	YY	YY	INTJ	UH	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	delta	delta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5567
# text = 3' enhancer and the immunoglobulin heavy-chain mu E1 site.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	'	'	PUNCT	``	_	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
7	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
11	E1	E1	NUM	CD	NumType=Card	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5568
# text = We have determined that the developmental control of immunoglobulin kappa 3' enhancer (kappa E3') activity is the result of the combined influence of positive- and negative-acting elements.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	'	'	PUNCT	``	_	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	result	result	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
34	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5569
# text = We show that a central core in the kappa E3' enhancer is active at the pre-B-cell stage but is repressed by flanking negative-acting elements.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
6	core	core	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	'	'	PUNCT	''	_	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
18	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	SCONJ	IN	_	_	_	_	_
26	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
30	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5570
# text = The negative-acting sequences repress enhancer activity in a position- and orientation-independent manner at the pre-B-cell stage.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	repress	repress	NOUN	NN	Number=Sing	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	orientation	orientation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
21	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5571
# text = We have isolated a human cDNA clone encoding a zinc finger protein (NF-E1) that binds to the negative-acting segment of the kappa E3' enhancer.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
7	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
8	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
11	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
25	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	'	'	PUNCT	''	_	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5572
# text = This protein also binds to the immunoglobulin heavy-chain enhancer mu E1 site.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
8	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
13	E1	E1	NUM	CD	NumType=Card	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5573
# text = NF-E1 is encoded by the same gene as the YY-1 protein, which binds to the adeno-associated virus P5 promoter.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	YY	YY	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	adeno	adeno	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	P5	p5	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5574
# text = NF-E1 is also the human homologue of the mouse delta protein, which binds to ribosomal protein gene promoters.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	ribosomal	ribosomal	VERB	VB	VerbForm=Inf	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5575
# text = The predicted amino acid sequence of this protein contains features characteristic of transcriptional activators as well as transcriptional repressors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	amino	amino	DET	DT	_	_	_	_	_
4	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
11	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5576
# text = Cotransfection studies with this cDNA indicate that it can repress basal promoter activity.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
11	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5577
# text = The apparent dual function of this protein is discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
3	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5578
# text = Document 003001403 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001403	003001403	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5579
# text = Cyclosporin
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5580
# text = A interferes with the inducible degradation of NF-kappa B inhibitors, but not with the processing of p105/NF-kappa B1 in T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	interferes	interfere	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5581
# text = The transcription factor NF-kappa B controls the induction of numerous cytokine promoters during the activation of T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5582
# text = Inhibition of T cell activation by the immunosuppressants cyclosporin A (CsA) and FK506 exerts a suppressive effect on the induction of these NF-kappa B-controlled cytokine promoters.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
9	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
10	A	A	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
16	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5583
# text = We show for human Jurkat T leukemia cells, as well as human and mouse primary T lymphocytes, that this inhibitory effect is accompanied by an impaired nuclear translocation of the Rel proteins c-Rel, RelA/p65 and NF-kappa B1/p50, whereas the nuclear appearance of RelB remains unaffected.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	mouse	mouse	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	NOUN	NN	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
30	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
34	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
46	B1/	b1/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	whereas	whereas	SCONJ	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
52	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
55	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
56	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5584
# text = CsA does not interfere with the synthesis of Rel proteins, but prevents the inducible degradation of cytosolic NF-kappa B inhibitors I kappa B alpha and I kappa B beta upon T cell activation.
1	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
2	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	inhibitors	inhibitor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
33	upon	upon	ADP	IN	_	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5585
# text = CsA neither inhibits the processing of the NF-kappa B1 precursor p105 to p50, nor does it "stabilize" the C-terminal portion of p105, I kappa
1	CsA	csa	ADP	IN	_	_	_	_	_
2	neither	neither	DET	DT	_	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	p105	p105	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	nor	nor	CCONJ	CC	_	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
21	stabilize	stabilize	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
22	"	"	PUNCT	''	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
26	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5586
# text = B gamma, which is degraded during p105 processing to mature p50.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	p105	p105	NUM	CD	NumType=Card	_	_	_	_
9	processing	process	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
12	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5587
# text = These results indicate that CsA interferes with a specific event in the signal-induced degradation of I kappa B alpha and I kappa B beta, but does not affect the processing of NF-kappa B1/p105 to p50.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
6	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	event	event	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	B	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B1/p105	b1/p105	PROPN	NNP	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5588
# text = Document 003001406 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001406	003001406	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5589
# text = Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	myricetin	myricetin	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	flavonoids	flavonoid	NOUN	NNS	Number=Plur	_	_	_	_
13	through	through	SCONJ	IN	_	_	_	_	_
14	downregulating	downregulat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	ECV	ECV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	304	304	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5590
# text = Flavonoids are a group of naturally-occurring phenolic compounds in the plant kingdom, and many flavonoids are found with vascular protective properties.
1	Flavonoids	Flavonoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	group	group	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	naturally	naturally	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
9	phenolic	phenolic	ADJ	JJ	Degree=Pos	_	_	_	_
10	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	plant	plant	NOUN	NN	Number=Sing	_	_	_	_
14	kingdom	kingdom	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
18	flavonoids	flavonoid	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
23	protective	protective	ADJ	JJ	Degree=Pos	_	_	_	_
24	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5591
# text = Nevertheless how the protective response is exerted by flavonoids is not well characterized.
1	Nevertheless	nevertheless	SCONJ	IN	_	_	_	_	_
2	how	how	ADV	WRB	PronType=Int	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protective	protective	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	flavonoids	flavonoid	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	well	well	ADV	RB	Degree=Pos	_	_	_	_
13	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5592
# text = In view of the nuclear factor-kappaB (NFkappaB) may play a central role in the initiation of atherosclerosis, prevention of the activation of NFkappaB represents an important role in protecting vascular injury.
1	In	in	ADP	IN	_	_	_	_	_
2	view	view	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	SCONJ	IN	_	_	_	_	_
34	protecting	protect	VERB	VBG	VerbForm=Ger	_	_	_	_
35	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
36	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5593
# text = In this study, the effects of flavonoids on NFkappaB/inhibitor-kappaB (IkappaB) system in ECV304 cells activated with tumor necrosis factor-alpha (TNFalpha) were examined.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	flavonoids	flavonoid	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	system	system	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	ECV304	ECV304	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5594
# text = We investigated the inhibitory action of six flavonoids on IkappaB kinase (IKK) activity, an enzyme recently found to phosphorylate critical serine residues of IkappaB for degradation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
5	action	action	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	six	six	NUM	CD	NumType=Card	_	_	_	_
8	flavonoids	flavonoid	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
19	recently	recently	ADV	RB	_	_	_	_	_
20	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
23	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
24	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
25	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5595
# text = Of six flavonoids tested, myricetin was found to strongly inhibit IKK kinase activity, and prevent the degradation of IkappaBalpha and IkappaBbeta in activated endothelial cells.
1	Of	of	ADP	IN	_	_	_	_	_
2	six	six	NUM	CD	NumType=Card	_	_	_	_
3	flavonoids	flavonoid	NOUN	NNS	Number=Plur	_	_	_	_
4	tested	tested	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	myricetin	myricetin	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	strongly	strongly	ADV	RB	_	_	_	_	_
11	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
12	IKK	IKK	NUM	CD	NumType=Card	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
24	in	in	ADV	RB	_	_	_	_	_
25	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5596
# text = Furthermore, myricetin was also found to inhibit NFkappaB activity correlated with suppression of monocyte adhesion to ECV304 cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	myricetin	myricetin	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
9	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	ECV	ECV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	304	304	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5597
# text = Therefore we conclude that flavonoids may be of therapeutic value for vascular disease through down regulation of NFkappaB/IkappaB system.
1	Therefore	therefore	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	flavonoids	flavonoid	NOUN	NNS	Number=Plur	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
10	value	value	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
13	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	down	down	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	_
21	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5598
# text = Copyright 1999 Wiley-Liss, Inc.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Wiley	Wiley	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	Liss	Liss	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Inc.	Inc.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5599
# text = Document 003001407 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001407	003001407	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5600
# text = Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.
1	Structural	Structural	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5601
# text = CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and erythrocytes parasitized with Plasmodium falciparum.
1	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
7	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
11	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
12	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	thrombospondin	thrombospondin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	collagens	collagen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IV	iv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	oxidized	oxidize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
27	density	density	NOUN	NN	Number=Sing	_	_	_	_
28	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
31	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	anionic	anionic	ADJ	JJ	Degree=Pos	_	_	_	_
34	phospholipids	phospholipid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	parasitized	parasitize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	Plasmodium	Plasmodium	NOUN	NN	Number=Sing	_	_	_	_
41	falciparum	falciparum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5602
# text = Its expression is restricted to a few cell types, including monocyte/macrophages.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
2	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5603
# text = In these cells, CD36 is involved in phagocytosis of apoptotic cells, and foam cell formation by uptake of oxidized low density lipoprotein.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	foam	foam	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	oxidized	oxidized	ADJ	JJ	Degree=Pos	_	_	_	_
22	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
23	density	density	NOUN	NN	Number=Sing	_	_	_	_
24	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5604
# text = To study the molecular mechanisms that control the transcription of the CD36 gene in monocytic cells we have isolated and analyzed the CD36 promoter.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	36	36	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5605
# text = Transient expression experiments of 5'-deletion fragments of the CD36 promoter coupled to luciferase demonstrated that as few as 158 base pairs upstream from the transcription initiation site were sufficient to direct the monocyte-specific transcription of the reporter gene.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	36	36	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
18	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	158	158	NUM	CD	NumType=Card	_	_	_	_
24	base	base	NOUN	NN	Number=Sing	_	_	_	_
25	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
26	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	direct	direct	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5606
# text = Within the above region, the fragment spanning nucleotides -158 to -90 was required for optimal transcription in monocytic cells.
1	Within	within	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	above	above	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
8	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
9	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	158	158	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	90	90	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5607
# text = Biochemical analysis of the region -158/-90 revealed a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103.
1	Biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	158/-90	158/-90	NUM	CD	NumType=Card	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	polyomavirus	polyomavirus	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	core-binding	core-binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	PEBP2/	PEBP2ith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	position	position	NOUN	NN	Number=Sing	_	_	_	_
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	103	103	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5608
# text = Disruption of the PEBP2/CBF site markedly diminished the role of the PEBP2/CBF factors in the constitutive transcription of the CD36 gene.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	markedly	markedly	ADV	RB	_	_	_	_	_
8	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	CBF	Cbf	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	36	36	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5609
# text = The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	members	member	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	chromosome	chromosome	ADJ	JJ	Degree=Pos	_	_	_	_
12	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
16	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	myeloperoxidase	myeloperoxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	highlights	highlight	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	_
53	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
54	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
58	by	by	ADP	IN	_	_	_	_	_
59	members	member	NOUN	NNS	Number=Plur	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	PEBP2/	Pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
64	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5610
# text = Document 003001412 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001412	003001412	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5611
# text = Transcription factor activation and functional stimulation of human monocytes.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5612
# text = Activation of expression of genes encoding transcription factors:
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 5613
# text = c-fos and c-jun and formation of AP1 transcriptional complex in human monocytes was investigated.
1	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	investigated	investigated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5614
# text = It was found that lipopolysaccharide induced strongly both c-fos and c-jun expression as well as AP1 formation.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	lipopolysaccharide	lipopolysaccharide	ADV	RB	_	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	strongly	strongly	ADV	RB	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
19	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5615
# text = Interferon gamma activated strongly c-fos and weakly c-jun and AP1.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	_
2	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
3	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	weakly	weakly	ADV	RB	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5616
# text = Tumor necrosis factor induced slightly c-fos and had almost no effect on c-jun and AP1.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	slightly	slightly	ADV	RB	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	almost	almost	ADV	RB	_	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5617
# text = The data suggest that differences in functional responses elicited in monocytes by all three factors may be dependent on different routes on nuclear signalling employed by the factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
9	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	all	all	DET	DT	_	_	_	_	_
14	three	three	NUM	CD	NumType=Card	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	routes	route	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
25	employed	employ	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5618
# text = Document 003001416 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001416	003001416	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5619
# text = Interferon-gamma modulates the lipopolysaccharide-induced expression of AP-1 and NF-kappa B at the mRNA and protein level in human monocytes.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
4	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5620
# text = Interferon-gamma (IFN-gamma) modulates the expression of several cytokines by human monocytes at the transcriptional level.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5621
# text = In view of these findings, we analyzed the effects of IFN-gamma on the expression of different transcription factors in activated human monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	view	view	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IFN	IFN	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5622
# text = Priming of human monocytes with IFN-gamma resulted in the down regulation of c-fos and c-jun mRNA in response to stimulation with lipopolysaccharide (LPS) compared to the effects of LPS alone.
1	Priming	Priming	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	down	down	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
37	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5623
# text = Not only was this effect observed at the mRNA level, but activator protein-1 (AP-1) DNA binding capacity was affected as well, A strong reduction was observed in the LPS-induced DNA-binding activity of AP-1 in the presence of IFN-gamma.
1	Not	not	ADV	RB	_	_	_	_	_
2	only	only	ADV	RB	_	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	as	as	ADV	RB	_	_	_	_	_
28	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
32	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
43	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5624
# text = LPS-stimulated monocytes showed an increased expression of p105 mRNA, the precursor of the p50 subunit of the transcription factor nuclear factor-kappa B (NF-kappa B), while no effect was noticed on the expression of p65 mRNA.
1	LPS	Lp	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	while	while	SCONJ	IN	_	_	_	_	_
36	no	no	DET	DT	_	_	_	_	_
37	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	noticed	notice	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	p65	p65	NUM	CD	NumType=Card	_	_	_	_
45	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5625
# text = In contrast, IFN-gamma priming did not affect the expression of p105 transcripts but enhanced the expression of p65 mRNA (two-fold).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	priming	priming	NOUN	NN	Number=Sing	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p105	p105	NUM	CD	NumType=Card	_	_	_	_
15	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	p65	p65	NUM	CD	NumType=Card	_	_	_	_
22	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5626
# text = Priming with IFN-gamma followed by LPS stimulation resulted in a further increase in the expression of p65 mRNA.
1	Priming	Prime	VERB	VBG	VerbForm=Ger	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
14	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	p65	p65	NUM	CD	NumType=Card	_	_	_	_
20	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5627
# text = This was due to an increase in the half-life of p65 mRNA (75 vs 150 minutes).
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	life	life	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	75	75	NUM	CD	NumType=Card	_	_	_	_
17	vs	v	NOUN	NNS	Number=Plur	_	_	_	_
18	150	150	NUM	CD	NumType=Card	_	_	_	_
19	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5628
# text = Electrophoretic mobility shift assays (EMSAs) demonstrated that unstimulated monocytes predominantly expressed p50 NF-kappa B. Stimulation with LPS or IFN-gamma resulted in the expression of p50 and p65 subunits, while the combination of IFN-gamma plus LPS caused a further increase in the expression of NF-kappa B.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	predominantly	predominantly	ADV	RB	_	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
19	Stimulation	Stimulation	PROPN	NNP	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
26	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	p50	p50	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	p65	p65	NUM	CD	NumType=Card	_	_	_	_
34	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	while	while	SCONJ	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
43	plus	plus	CCONJ	CC	_	_	_	_	_
44	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
45	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
48	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
56	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5629
# text = With Western blotting, it was shown that nuclear extracts from monocytes contained p50 and p65 protein in response to LPS and IFN-gamma stimulation.
1	With	with	ADP	IN	_	_	_	_	_
2	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
3	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	p65	p65	NUM	CD	NumType=Card	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
26	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5630
# text = However, the combined stimulation did not result in enhanced p50 and p65 protein expression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	result	result	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5631
# text = The effects of IFN-gamma on the transcription factors were specific, since no change was observed in the expression of NF-IL-6 or I kappa B alpha, the inhibitor of NF-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFN	IFN	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	since	since	SCONJ	IN	_	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	change	change	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	6	6	NUM	CD	NumType=Card	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5632
# text = We conclude that the effects of IFN-gamma on the expression of the transcription factors AP-1 and NF-kappa B may be important for the modulatory effects of IFN-gamma on the cytokine expression in activated human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IFN	IFN	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	AP	ap	ADV	RB	_	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	modulatory	modulatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IFN	IFN	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
36	on	on	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5633
# text = Document 003001420 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001420	003001420	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5634
# text = Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development.
1	Potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
4	attenuation	attenuation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	live	live	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	gain	gain	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IkappaB-	IkappaB-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	alphaS32/	alphas32/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	36A	36A	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	vaccine	vaccine	NOUN	NN	Number=Sing	_	_	_	_
33	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5635
# text = Live-attenuated human immunodeficiency viruses (HIVs) are candidates for Acquired Immunodeficiency Syndrome (AIDS) vaccine.
1	Live	Live	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIVs	HIV	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	candidates	candidate	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	Acquired	acquired	PROPN	NNP	Number=Sing	_	_	_	_
14	Immunodeficiency	Immunodeficiency	PROPN	NNP	Number=Sing	_	_	_	_
15	Syndrome	Syndrome	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	vaccine	vaccine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5636
# text = Based on the simian immunodeficiency virus (SIV) model for AIDS, loss-of-function (e.g. deletion of accessory genes such as nef) has been forwarded as a primary approach for creating enfeebled, but replication-competent, HIV-1/SIV.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	SIV	SIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	model	model	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	e.g.	e.g.	X	FW	_	_	_	_	_
21	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	nef	nef	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	forwarded	forward	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
35	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
36	for	for	SCONJ	IN	_	_	_	_	_
37	creating	create	VERB	VBG	VerbForm=Ger	_	_	_	_
38	enfeebled	enfeebled	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	competent	competent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
48	SIV	Siv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5637
# text = Regrettably, recent evidence suggests that loss-of-function alone is not always sufficient to prevent the emergence of virulent mutants.
1	Regrettably	Regrettably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	loss	lose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	function	function	NOUN	NN	Number=Sing	_	_	_	_
12	alone	alone	ADV	RB	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	always	always	ADV	RB	_	_	_	_	_
16	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	virulent	virulent	ADJ	JJ	Degree=Pos	_	_	_	_
23	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5638
# text = New strategies that attenuate via mechanisms distinct from loss-of-function are needed for enhancing the safety phenotype of viral genome.
1	New	new	ADJ	JJ	Degree=Pos	_	_	_	_
2	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	attenuate	attenuate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	via	via	ADP	IN	_	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	for	for	SCONJ	IN	_	_	_	_	_
17	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	safety	safety	NOUN	NN	Number=Sing	_	_	_	_
20	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5639
# text = Here, we propose gain-of-function to be used simultaneously with loss-of-function as a novel approach for attenuating HIV-1.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	gain	gain	ADV	RB	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	function	function	NOUN	NN	Number=Sing	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
23	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	SCONJ	IN	_	_	_	_	_
25	attenuating	attenuating	VERB	VBG	VerbForm=Ger	_	_	_	_
26	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5640
# text = We have constructed an HIV-1 genome carrying the cDNA of a proteolysis-resistant nuclear factor-kappaB inhibitor (IkappaB-alphaS32/36A) in the nef region.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
9	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	IkappaB-alphaS32/	Ikappab-alphas32/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	36A	36a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5641
# text = HIV-1 expressing IkappaB-alphaS32/36A down-regulates viral expression and is highly attenuated in both Jurkat and peripheral blood mononuclear cells.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	expressing	expressing	NOUN	NN	Number=Sing	_	_	_	_
5	IkappaB-	IkappaB-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
6	alphaS32/36A	alphaS32/36a	X	GW	_	_	_	_	_
7	down	down	X	GW	_	_	_	_	SpaceAfter=No
8	-regulates	-regulate	X	GW	_	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5642
# text = We provide formal proof that the phenotypic and attenuating characteristics of IkappaB-alphaS32/36A permit its stable maintenance in a live, replicating HIV-1 despite 180 days of forced ex vivo passaging in tissue culture.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	formal	formal	ADJ	JJ	Degree=Pos	_	_	_	_
4	proof	proof	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	phenotypic	phenotypic	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	attenuating	attenuating	VERB	VBG	VerbForm=Ger	_	_	_	_
10	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IkappaB-	Ikappab-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	alphaS32/	alphas32/	SYM	SYM	_	_	_	_	SpaceAfter=No
14	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	permit	permit	NOUN	NN	Number=Sing	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
18	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
20	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	live	live	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	replicating	replicating	VERB	VBG	VerbForm=Ger	_	_	_	_
26	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	despite	despite	ADP	IN	_	_	_	_	_
30	180	180	NUM	CD	NumType=Card	_	_	_	_
31	days	day	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	forced	force	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	ex	ex	NOUN	NN	Number=Sing	_	_	_	_
35	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
36	passaging	passaging	VERB	VBG	VerbForm=Ger	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
39	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5643
# text = As compared with other open-reading frames embedded into HIV/SIV genome, this degree of stability is unprecedented.
1	As	as	SCONJ	IN	_	_	_	_	_
2	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	open	open	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
8	frames	frame	NOUN	NNS	Number=Plur	_	_	_	_
9	embedded	embed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	SIV	SIV	PROPN	NNP	Number=Sing	_	_	_	_
14	genome	genome	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unprecedented	unprecedented	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5644
# text = Thus, IkappaB-alphaS32/36A offers proof-of-principle that artifactually gained functions, when used to attenuate the replication of live HIV-1, can be stable.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IkappaB-	IkappaB-	X	GW	_	_	_	_	SpaceAfter=No
4	alphaS32/36A	alphaS32/36a	X	FW	Foreign=Yes	_	_	_	_
5	offers	offer	X	GW	_	_	_	_	_
6	proof	proof	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	principle	principle	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	artifactually	artifactually	ADV	RB	_	_	_	_	_
13	gained	gain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	attenuate	attenuate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	live	live	ADJ	JJ	Degree=Pos	_	_	_	_
24	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5645
# text = These findings illustrate gain-of-function as a feasible strategy for developing safer live-attenuated HIVs to be tested as candidates for AIDS vaccine.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	illustrate	illustrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	gain	gain	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	function	function	NOUN	NN	Number=Sing	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	feasible	feasible	ADJ	JJ	Degree=Pos	_	_	_	_
12	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	SCONJ	IN	_	_	_	_	_
14	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
15	safer	safer	ADJ	JJR	Degree=Cmp	_	_	_	_
16	live	live	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	HIVs	HIV	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	candidates	candidate	NOUN	NNS	Number=Plur	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
27	vaccine	vaccine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5646
# text = Document 003001421 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001421	003001421	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5647
# text = Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation.
1	Control	Control	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	X	GW	_	_	_	_	_
5	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
6	alpha	alpha	X	GW	_	_	_	_	_
7	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5648
# text = I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	GW	_	_	_	_	_
3	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
4	alpha	alpha	X	GW	_	_	_	_	_
5	inhibits	inhibits	X	ADD	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	retaining	retain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5649
# text = Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	typically	typically	ADV	RB	_	_	_	_	_
5	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	rapidly	rapidly	ADV	RB	_	_	_	_	_
13	inactivate	inactivate	ADJ	JJ	Degree=Pos	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	X	GW	_	_	_	_	_
16	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5650
# text = This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes important for the defense of the organism.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	liberates	liberate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	translocate	translocate	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	initiate	initiate	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	organism	organism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5651
# text = Activation of NF-kappa B correlates with phosphorylation of I kappa B-alpha and requires the proteolysis of this inhibitor.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5652
# text = When either serine-32 or serine-36 of I kappa B-alpha was mutated, the protein did not undergo signal-induced phosphorylation or degradation, and NF-kappa B could not be activated.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	either	either	CCONJ	CC	_	_	_	_	_
3	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	32	32	NUM	CD	NumType=Card	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	36	36	NUM	CD	NumType=Card	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	undergo	undergo	ADV	RB	_	_	_	_	_
23	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5653
# text = These results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5654
# text = Document 003001426 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001426	003001426	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5655
# text = TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation.
1	TAR	Tar	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CNS	Cn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5656
# text = The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for productive infection and is a potential target for antiviral therapy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	X	LS	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
19	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
27	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5657
# text = Tat, a potent activator of HIV-1 gene expression, serves to greatly increase the rate of transcription directed by the viral promoter.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
5	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	greatly	greatly	ADV	RB	_	_	_	_	_
16	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5658
# text = This induction, which seems to be an important component in the progression of acquired immune deficiency syndrome (AIDS), may be due to increased transcriptional initiation, increased transcriptional elongation, or a combination of these processes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	acquired	acquire	ADJ	JJ	Degree=Pos	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
18	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	due	due	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
40	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5659
# text = Much attention has been focused on the interaction of Tat with a specific RNA target termed TAR (transactivation responsive) which is present in the leader sequence of all HIV-1 mRNAs.
1	Much	much	ADJ	JJ	Degree=Pos	_	_	_	_
2	attention	attention	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
15	target	target	AUX	VB	VerbForm=Inf	_	_	_	_
16	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	TAR	Tar	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	all	all	DET	DT	_	_	_	_	_
31	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5660
# text = This interaction is believed to be an important component of the mechanism of transactivation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5661
# text = In this report we demonstrate that in certain CNS-derived cells
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
9	CNS	CNS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 5662
# text = Tat is capable of activating HIV-1 through a TAR-independent pathway.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
4	of	of	SCONJ	IN	_	_	_	_	_
5	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	TAR	Tar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5663
# text = A Tat-responsive element is found upstream within the viral promoter that in glial-derived cell lines allows transactivation in the absence of TAR.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	TAR	TAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5664
# text = Deletion mapping and hybrid promoter constructs demonstrate that the newly identified Tat-responsive element corresponds to a sequence within the viral long terminal repeat (LTR) previously identified as the HIV-1 enhancer, or NF-kappa B domain.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	newly	newly	ADV	RB	_	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	corresponds	correspond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
24	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
25	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	previously	previously	ADV	RB	_	_	_	_	_
30	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5665
# text = DNA band-shift analysis reveals NF-kappa B binding activity in glial cells that differs from that present in T lymphoid cells.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	band	band	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	differs	differ	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	present	present	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5666
# text = Further, we observe that TAR-deleted mutants of HIV-1 demonstrate normal late gene expression in glial cells as evidenced by syncytia formation and production of viral p24 antigen.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	observe	observe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	TAR	Tar	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	_
26	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
31	p24	p24	NOUN	NN	Number=Sing	_	_	_	_
32	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5667
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5668
# text = Document 003001427 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001427	003001427	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5669
# text = Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex: role of tumor necrosis factor alpha.
1	Biphasic	Biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5670
# text = The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex in primary human T cells has been studied at various times after activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	/CD3	/CD3	NUM	CD	NumType=Card	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
33	times	time	NOUN	NNS	Number=Plur	_	_	_	_
34	after	after	ADP	IN	_	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5671
# text = Only p50 NF-kappa B protein bound the kappa B element of interleukin-2 receptor (IL-2R) alpha chain promoter on resting T cells.
1	Only	only	ADV	RB	_	_	_	_	_
2	p50	p50	NUM	CD	NumType=Card	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	bound	bound	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2R	2r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	SCONJ	IN	_	_	_	_	_
27	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5672
# text = However, immediately after TcR/CD3 cross-linking (after approximately 1 h; immediate) binding of p50.p65 heterodimers was observed.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	immediately	immediately	ADV	RB	_	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	TcR/	TcR/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
7	cross-linking	cross-linking	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	after	after	ADP	IN	_	_	_	_	_
10	approximately	approximately	ADV	RB	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	p50.p65	p50.p65	NOUN	NN	Number=Sing	_	_	_	_
19	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	observed	observed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5673
# text = p50.c-rel heterodimers were also detected bound to this sequence at early time points (7-16 h; early), and both remained active at later time points (40 h; late) after activation.
1	p50.c	p50.c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-rel	-rel	ADJ	JJ	Degree=Pos	_	_	_	_
3	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	time	time	NOUN	NN	Number=Sing	_	_	_	_
14	points	point	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	16	16	NUM	CD	NumType=Card	_	_	_	_
19	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	early	early	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	both	both	ADV	RB	_	_	_	_	_
26	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
30	time	time	NOUN	NN	Number=Sing	_	_	_	_
31	points	point	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	40	40	NUM	CD	NumType=Card	_	_	_	_
34	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	late	late	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	after	after	ADP	IN	_	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5674
# text = This regulation takes place mainly at the level of nuclear translocation of p65 and c-rel, at immediate and early time points.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	takes	take	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	place	place	NOUN	NN	Number=Sing	_	_	_	_
5	mainly	mainly	ADV	RB	_	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
22	time	time	NOUN	NN	Number=Sing	_	_	_	_
23	points	point	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5675
# text = Activation also induced c-rel and p105/p50 mRNA synthesis, but not p65 mRNA whose expression was constitutive.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	p50	p50	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	p65	p65	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
17	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5676
# text = Interestingly, all those early and late events, but not the immediate ones, were inhibited by a neutralizing anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
14	ones	one	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	neutralizing	neutralize	NOUN	NN	Number=Sing	_	_	_	_
21	anti-tumor	anti-tumor	ADP	IN	_	_	_	_	_
22	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
31	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5677
# text = Similarly, cycloheximide prevented the p65 and c-rel translocation and consequent formation of active binding heterodimers, at early and late times.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
4	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
13	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
23	times	time	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5678
# text = Cyclosporin
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5679
# text = A impaired not only early and late, but also immediate events; however, addition of TNF-alpha prevented all inhibition.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
3	not	not	ADV	RB	_	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	late	late	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
12	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
21	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	all	all	DET	DT	_	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5680
# text = These results indicate that the regulation of NF-kappa B activation during T cell activation by TcR/CD3 signals is biphasic: TcR/CD3 triggers its immediate translocation, which is transient if no TNF-alpha is present.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TcR/CD3	TcR/CD3	NUM	CD	NumType=Card	_	_	_	_
19	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	biphasic	biphasic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	:	:	PUNCT	:	_	_	_	_	_
23	TcR/CD3	TcR/CD3	NUM	CD	NumType=Card	_	_	_	_
24	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
27	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	transient	transient	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	if	if	SCONJ	IN	_	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5681
# text = TNF-alpha, therefore, emerges as the main factor responsible for a second phase of NF-kappa B regulation, controlling both translocation of p65 and c-rel, and new mRNA synthesis for c-rel and p105/p50.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	emerges	emerge	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	p65	p65	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
35	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
36	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
39	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5682
# text = Document 003001429 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001429	003001429	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5683
# text = ATF1 and CREB trans-activate a cell cycle regulated histone
1	ATF1	Atf1	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	CREB	Creb	PROPN	NNP	Number=Sing	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	histone	histone	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5684
# text = H4 gene at a distal nuclear matrix associated promoter element.
1	H4	H4	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5685
# text = Proteins of the ATF/CREB class of transcription factors stimulate gene expression of several cell growth-related genes through protein kinase A-related cAMP response elements.
1	Proteins	Protein	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ATF/CREB	ATF/CREB	PROPN	NNP	Number=Sing	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
25	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5686
# text = The promoter activity of cell cycle regulated histone
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	histone	histone	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5687
# text = H4 genes is regulated by at least four principal cis-acting elements which mediate G1/S phase control and/or enhancement of transcription during the cell cycle.
1	H4	H4	NUM	CD	NumType=Card	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	at	at	ADV	RB	_	_	_	_	_
7	least	least	ADV	RBS	Degree=Sup	_	_	_	_
8	four	four	NUM	CD	NumType=Card	_	_	_	_
9	principal	principal	NOUN	NN	Number=Sing	_	_	_	_
10	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	G1/	G1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	S	's	PROPN	NNP	Number=Sing	_	_	_	_
17	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	or	or	CCONJ	CC	_	_	_	_	_
22	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5688
# text = Using protein-DNA interaction assays we show that the H4 promoter contains two ATF/CREB recognition motifs which interact with CREB, ATF1, and ATF2 but not with ATF4/CREB2.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	H4	H4	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	ATF/CREB	Atf/creb	ADJ	JJ	Degree=Pos	_	_	_	_
16	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	ATF1	ATF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	ATF2	ATF2	NOUN	NN	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	ATF4/	Atf4/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	CREB2	Creb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5689
# text = One ATF/CRE motif is located in the distal promoter at the nuclear matrix-associated Site IV, and the second motif is present in the proximal promoter at Site I.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	ATF/CRE	Atf/cre	NOUN	NN	Number=Sing	_	_	_	_
3	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	Site	site	NOUN	NN	Number=Sing	_	_	_	_
17	IV	iv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
22	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	Site	site	PROPN	NNP	Number=Sing	_	_	_	_
31	I	I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5690
# text = Both ATF
1	Both	both	DET	DT	_	_	_	_	_
2	ATF	Atf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 5691
# text = /CRE motifs overlap binding sequences for the multifunctional YY1 transcription factor, which has previously been shown to be nuclear matrix associated.
1	/CRE	/cre	ADJ	JJ	Degree=Pos	_	_	_	_
2	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
3	overlap	overlap	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	multifunctional	multifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
9	YY1	yy1	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	previously	previously	ADV	RB	_	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
22	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5692
# text = Subnuclear fractionation reveals that there are two ATF1 isoforms which appear to differ with respect to DNA binding activity and partition selectively between nuclear matrix and nonmatrix compartments, consistent with the role of the nuclear matrix in regulating gene expression.
1	Subnuclear	Subnuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	fractionation	fractionation	NOUN	NN	Number=Sing	_	_	_	_
3	reveals	reveal	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	there	there	PRON	EX	_	_	_	_	_
6	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	ATF1	ATF1	NUM	CD	NumType=Card	_	_	_	_
9	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	partition	partition	NOUN	NN	Number=Sing	_	_	_	_
22	selectively	selectively	ADV	RB	_	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	nonmatrix	nonmatrix	NOUN	NN	Number=Sing	_	_	_	_
28	compartments	compartment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	role	role	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	SCONJ	IN	_	_	_	_	_
39	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
40	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5693
# text = Site-directed mutational studies demonstrate that Site I and Site IV together support ATF1- and CREB-induced trans-activation of the H4 promoter.
1	Site-	Site-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	mutational	mutational	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	studie	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Site	site	PROPN	NNP	Number=Sing	_	_	_	_
8	I	I	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Site	site	PROPN	NNP	Number=Sing	_	_	_	_
11	IV	iv	PROPN	NNP	Number=Sing	_	_	_	_
12	together	together	ADV	RB	_	_	_	_	_
13	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	ATF1	Atf1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	H4	H4	PROPN	NNP	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5694
# text = Thus, our data establish that ATF/CREB factors functionally modulate histone
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	ATF/CREB	Atf/creb	PROPN	NNP	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	functionally	functionally	ADV	RB	_	_	_	_	_
10	modulate	modulate	ADJ	JJ	Degree=Pos	_	_	_	_
11	histone	histone	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5695
# text = H4 gene transcription at distal and proximal promoter elements.
1	H4	H4	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5696
# text = Document 003001432 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001432	003001432	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5697
# text = Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	post	post	X	AFX	_	_	_	_	SpaceAfter=No
4	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5698
# text = AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA).
1	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
7	product	product	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
27	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
31	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
32	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	O	of	INTJ	UH	_	_	_	_	SpaceAfter=No
37	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
38	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5699
# text = We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	60	60	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5700
# text = Low levels of c-jun transcripts were detectable in untreated HL-60 leukemic cells, increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA.
1	Low	low	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
11	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	significantly	significantly	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	6	6	NUM	CD	NumType=Card	_	_	_	_
21	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	reached	reach	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	near	near	ADP	IN	_	_	_	_	_
26	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	24	24	NUM	CD	NumType=Card	_	_	_	_
30	h	h	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	32	32	NUM	CD	NumType=Card	_	_	_	_
35	nM	nM	PROPN	NNP	Number=Sing	_	_	_	_
36	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5701
# text = Similar kinetics of c-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	937	937	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5702
# text = Similar findings were obtained with bryostatin 1 (10 nM), another activator of protein kinase C and inducer of monocytic differentiation.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	bryostatin	bryostatin	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	nM	nm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	another	another	DET	DT	_	_	_	_	_
14	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	C	c	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5703
# text = Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces HL-60 monocytic differentiation, increased c-jun expression.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
6	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
9	microM	microm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	structurally	structurally	ADV	RB	_	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	60	60	NUM	CD	NumType=Card	_	_	_	_
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5704
# text = TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts.
1	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	60	60	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	superinduction	superinduction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5705
# text = Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated HL-60 cells, and that exposure to TPA increases this rate 3.3-fold.
1	Run	run	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	on	on	ADP	IN	_	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
15	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	60	60	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
25	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
28	3.3	3.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5706
# text = Treatment of HL-60 cells with both TPA and cycloheximide had no effect on the rates of c-jun transcription.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	rates	rate	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5707
# text = The half-life of c-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	life	life	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
8	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
9	as	as	ADV	RB	_	_	_	_	_
10	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	60	60	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	actinomycin	actinomycin	PROPN	NNP	Number=Sing	_	_	_	_
21	D	d	PROPN	NNP	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	30	30	NUM	CD	NumType=Card	_	_	_	_
24	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5708
# text = In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	life	life	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
11	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	60	60	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	cycloheximide	cycloheximide	VERB	VB	VerbForm=Inf	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	actinomycin	actinomycin	VERB	VB	VerbForm=Inf	_	_	_	_
25	D	d	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5709
# text = These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
10	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
11	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	post	post	X	AFX	_	_	_	_	SpaceAfter=No
25	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5710
# text = Document 003001433 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001433	003001433	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5711
# text = Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-beta site.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	differentiated	differentiated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-like	-like	ADJ	JJ	Degree=Pos	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
24	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	EBP-	EBP-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	beta	beof	NOUN	NN	Number=Sing	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5712
# text = In this report, we demonstrate that the AP-1 site and a distal promoter element regulate transcriptional induction of collagenase-1 during monocytic differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5713
# text = Chloramphenicol acetyltransferase expression constructs containing regions of the human collagenase-1 promoter were stably or transiently transfected into U937 cells, and reporter activity was assessed at various times after the onset of phorbol 12-myristate 13-acetate (PMA)-mediated differentiation.
1	Chloramphenicol	Chloramphenicol	PROPN	NNP	Number=Sing	_	_	_	_
2	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	stably	stably	ADV	RB	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	transiently	transiently	ADV	RB	_	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	into	into	ADP	IN	_	_	_	_	_
20	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
30	times	time	NOUN	NNS	Number=Plur	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
36	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
38	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
39	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5714
# text = Rapid and strong induction of promoter activity was lost in constructs with a mutant AP-1 element; however, at 16-96
1	Rapid	rapid	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	96	96	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 5715
# text = h post-PMA, the mutant collagenase-1 promoter displayed AP-1 independent PMA-mediated transactivation.
1	h	h	INTJ	UH	_	_	_	_	_
2	post	post	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
8	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5716
# text = The AP-1 mutant constructs also showed delayed transcriptional activation in PMA-treated fibroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5717
# text = Western and supershift analyses indicated that functional Jun and Fos proteins were present in nuclear extracts of PMA-differentiated U937 cells.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
4	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
5	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	differentiated	differentiate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	U937	U937	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5718
# text = Promoter deletion constructs demonstrated the potential role of distal promoter sequences in regulating collagenase-1 transcription.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5719
# text = In particular, Western, supershift, and promoter deletion analyses suggested a role for CCAAT/enhancer-binding protein-beta (C/EBP-beta) binding site between -2010 and -1954 in regulating transcription of collagenase-1 in monocytic cells.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Western	western	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
10	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
11	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
12	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	CCAAT	CCAAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	C/	Cith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	2010	2010	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
36	1954	1954	NUM	CD	NumType=Card	_	_	_	_
37	in	in	SCONJ	IN	_	_	_	_	_
38	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5720
# text = Our findings suggest that distinct regulatory elements, acting somewhat independently of each other, control expression of collagenase-1.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
10	somewhat	somewhat	ADV	RB	_	_	_	_	_
11	independently	independently	ADV	RB	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	each	each	DET	DT	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5721
# text = In addition, our data suggests that the rapid PMA-mediated induction of collagenase-1 transcription is controlled by a mechanism distinct from that regulating the sustained expression of this proteinase in activated macrophages.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
10	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
24	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	proteinase	proteinase	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5722
# text = Document 003001436 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001436	003001436	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5723
# text = Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.
1	Cloning	Cloning	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
21	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
27	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5724
# text = We have cloned and characterized a mitogen-inducible gene isolated from human T cells that predicts a protein of 968 amino acids.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	predicts	predict	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	968	968	NUM	CD	NumType=Card	_	_	_	_
22	amino	amino	DET	DT	_	_	_	_	_
23	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5725
# text = The amino-terminal domain has regions homologous to the oncogene rel and to the developmentally important gene dorsal of Drosophila.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
8	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
12	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	developmentally	developmentally	ADV	RB	_	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	dorsal	dorsal	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5726
# text = The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans, as well as in the putative human oncogene bcl-3 and in the ankyrin protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	repeat	repeat	ADJ	JJ	Degree=Pos	_	_	_	_
8	structures	structure	NOUN	NNS	Number=Plur	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
22	control	control	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Ceanorhabditis	Ceanorhabditis	PROPN	NNP	Number=Sing	_	_	_	_
33	elegans	elegan	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	as	as	ADV	RB	_	_	_	_	_
36	well	well	ADV	RB	Degree=Pos	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
43	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	3	3	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	ankyrin	ankyrin	ADJ	JJ	Degree=Pos	_	_	_	_
50	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5727
# text = A truncated form of the product of this gene translated in vitro is a DNA-binding protein which interacts specifically with the kappa B binding site found in many inducible genes, including the enhancer in human immunodeficiency virus.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	truncated	truncated	ADJ	JJ	Degree=Pos	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	product	product	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	specifically	specifically	ADV	RB	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
40	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5728
# text = This gene is yet another in a growing list of important regulatory molecules whose expression is transcriptionally induced upon cellular activation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	yet	yet	ADV	RB	_	_	_	_	_
5	another	another	DET	DT	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	list	list	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
14	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	upon	upon	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5729
# text = Document 003001437 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001437	003001437	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5730
# text = NF-kappa
1	NF	NF	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5731
# text = B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells.
1	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	ADJ	JJ	Degree=Pos	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	members	member	NOUN	NNS	Number=Plur	_	_	_	_
6	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5732
# text = A kappa B-site was identified in the promoter of the intercellular adhesion molecule-1 (ICAM-1) gene, which is involved in regulation of ICAM-1 expression by tumor necrosis factor alpha (TNF-alpha) and glucocorticoids.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	ICAM	ICAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5733
# text = We now report on the transcription factors which bind and transactivate this enhancer sequence.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	transactivate	transactivate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5734
# text = In vitro, the ICAM-1 kappa B site appeared to bind RelA and c-Rel homodimers as well as heterodimers with NF-kappa B1, but weakly NF-kappa B1 homodimers.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
14	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
19	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADV	RB	_	_	_	_	_
21	well	well	ADV	RB	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B1	B1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	weakly	weakly	ADV	RB	_	_	_	_	_
32	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B1	B1	NOUN	NN	Number=Sing	_	_	_	_
36	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5735
# text = In addition, both RelA and c-Rel, but not NF-kappa B1, were shown to transactivate an ICAM-1 kappa B-reporter construct.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B1	b1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5736
# text = In monocytic THP-1 cells TNF-alpha induced two nuclear complexes which in vitro bound to the ICAM-1 kappa B site.
1	In	in	ADP	IN	_	_	_	_	_
2	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
17	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5737
# text = Using antibodies in an electrophoretic mobility supershift assay, one of these complexes was shown to contain NF-kappa B1 and RelA, and to bind with higher affinity to the consensus kappa B site in the HIV long terminal repeat.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
6	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
7	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
8	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	one	one	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
30	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
40	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
41	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
42	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5738
# text = The second complex contained RelA, and exhibited higher affinity towards the ICAM-1 kappa B than to the HIV kappa B site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	RelA	Rela	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	towards	towards	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5739
# text = The glucocorticoid receptor was shown to repress activity of both the RelA homodimer and the NF-kappa B1/RelA heterodimer.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
13	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B1	b1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	RelA	Rela	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5740
# text = We argue that in vivo RelA homodimers are likely to play a dominant role in TNF-alpha-induced ICAM-1 transcription in monocytic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	argue	argue	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
6	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
7	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5741
# text = Document 003001441 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001441	003001441	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5742
# text = Activity of the kappa B enhancer of the interleukin-2 receptor alpha chain in somatic cell hybrids is accompanied by the nuclear localization of NF-kappa B.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5743
# text = The two nuclear proteins NF-kappa B (consisting of subunits p50 and p65) and the DNA-binding subunit of NF-kappa B (p50) by itself, also called KBF1, are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	B	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	KBF1	Kbf1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	constitutively	constitutively	ADV	RB	_	_	_	_	_
40	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
49	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	line	line	NOUN	NN	Number=Sing	_	_	_	_
52	IARC	Iarc	NOUN	NN	Number=Sing	_	_	_	_
53	301.5	301.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5744
# text = In order to define the roles of these two factors, which bind to the same kappa B enhancers, in transcription activation we have prepared somatic cell hybrids between IARC 301.5 and a murine myeloma.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	IARC	IARC	PROPN	NNP	Number=Sing	_	_	_	_
32	301.5	301.5	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
36	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5745
# text = Most hybrids express both KBF1 and NF-kappa B in their nuclei, but one hybrid expresses only KBF1.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
18	expresses	express	NOUN	NNS	Number=Plur	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5746
# text = The kappa B enhancer of the gene encoding the interleukin-2 (IL-2) receptor alpha chain (IL-2R alpha) is functional only in the hybrids expressing nuclear NF-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
29	only	only	ADV	RB	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
33	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5747
# text = These findings show that nuclear NF-kappa B is necessary to activate the kappa B enhancer, while KBF1 by itself is not sufficient.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	KBF1	KBF1	NUM	CD	NumType=Card	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5748
# text = We propose that KBF1 is a competitive inhibitor of NF-kappa B and discuss how these factors may be involved in the transient expression of IL-2 and IL-2R alpha genes during the immune response.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	how	how	ADV	WRB	PronType=Int	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
34	alpha	alpha	ADP	IN	_	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	during	during	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5749
# text = Document 003001444 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001444	003001444	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5750
# text = Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
7	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5751
# text = The T cell surface molecule CD28 binds to ligands on accessory cells and APCs, playing an important costimulatory role in the response of T cells to Ags.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
5	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
6	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
7	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	APCs	APC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	playing	play	VERB	VBG	VerbForm=Ger	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
19	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	Ags	ag	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5752
# text = Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	knowledge	knowledge	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
8	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	incomplete	incomplete	ADV	RB	_	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5753
# text = In addition to activation of phospholipase C gamma 1, ligation of this receptor also seems to activate a calcium-independent, CD28-specific pathway.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5754
# text = In this paper, we report that cross-linking of CD28 (but not CD2, CD5, LFA-1, or CD7) leads to an elevation of c-jun mRNA, with only minimal activation of c-fos expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-linking	-link	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	CD5	CD5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	CD7	CD7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
32	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
33	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	only	only	ADV	RB	_	_	_	_	_
37	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5755
# text = CD28-dependent induction of c-jun expression requires protein tyrosine kinase activity, but does not depend on activation of a phorbol ester-responsive protein kinase C or elevation of cytosolic calcium.
1	CD28	CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
23	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	C	c	NOUN	NN	Number=Sing	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
33	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5756
# text = Furthermore, CD28-dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
9	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5757
# text = A mechanism is suggested whereby expression of c-jun and junB, in the absence of members of the fos family, can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	whereby	whereby	ADP	IN	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	junB	junb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	members	member	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
21	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
25	inappropriate	inappropriate	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
41	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
42	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5758
# text = Document 003001449 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001449	003001449	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5759
# text = Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.
1	Antioxidants	Antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
2	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	SCONJ	IN	_	_	_	_	_
6	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
28	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5760
# text = Cell adhesion to endothelial cells stimulated by tumor necrosis factor-alpha (TNF) is due to induction of surface receptors, such as vascular cell adhesion molecule-1 (VCAM-1).
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	due	due	ADP	IN	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
29	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5761
# text = The antioxidant pyrrolidine dithiocarbamate (PDTC) specifically inhibits activation of nuclear factor-kappa B (NF-kappa B).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
3	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
4	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5762
# text = Since kappa B motifs are present in VCAM-1 and intercellular adhesion molecule-1 (ICAM-1) promoters, we used PDTC to study the regulatory mechanisms of VCAM-1 and ICAM-1 induction and subsequent monocyte adhesion in TNF-treated human umbilical vein endothelial cells (HUVECs).
1	Since	since	ADP	IN	_	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
43	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
44	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
50	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
51	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
52	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5763
# text = PDTC or N-acetylcysteine dose dependently reduced TNF-induced VCAM-1 but not ICAM-1 surface protein (also in human umbilical arterial endothelial cells) and mRNA expression (by 70% at 100 mumol/L PDTC) in HUVECs as assessed by flow cytometry and polymerase chain reaction.
1	PDTC	Pdtc	NOUN	NN	Number=Sing	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	acetylcysteine	acetylcysteine	PRON	PRP	_	_	_	_	_
5	dose	dose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	dependently	dependently	ADV	RB	_	_	_	_	_
7	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	also	also	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
26	arterial	arterial	NOUN	NN	Number=Sing	_	_	_	_
27	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	by	by	ADP	IN	_	_	_	_	_
35	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	%	%	SYM	NN	Number=Sing	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	100	100	NUM	CD	NumType=Card	_	_	_	_
39	mumol/L	mumol/L	PROPN	NNP	Number=Sing	_	_	_	_
40	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	HUVECs	Huvecs	PROPN	NNP	Number=Sing	_	_	_	_
44	as	as	SCONJ	IN	_	_	_	_	_
45	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
48	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
51	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
52	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5764
# text = Gel-shift analysis in HUVECs demonstrated that PDTC prevented NF-kappa B mobilization by TNF, suggesting that only VCAM-1 induction was controlled by NF-kappa B.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
7	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
10	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5765
# text = Since HUVECs released superoxide anions in response to TNF, and H2O2 induces VCAM-1, PDTC may act as a radical scavenger.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
3	released	release	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	superoxide	superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
5	anions	anion	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
13	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
14	VCAM	VCAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
24	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5766
# text = Although ICAM-1 induction was unaffected, inhibitors of NADPH oxidase (apocynin) or cytochrome P-450 (SKF525a) suppressed VCAM-1 induction by TNF, revealing that several radical-generating systems are involved in its regulation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NADPH	NADPH	DET	DT	_	_	_	_	_
12	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	apocynin	apocynin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	cytochrome	cytochrome	NOUN	NN	Number=Sing	_	_	_	_
18	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	450	450	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	SKF	SKF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	525	525	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	VCAM	VCAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	revealing	reveal	VERB	VBG	VerbForm=Ger	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
36	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	generating	generating	NOUN	NN	Number=Sing	_	_	_	_
39	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
40	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
44	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5767
# text = PDTC, apocynin, or SKF525a decreased adhesion of monocytic U937 cells to TNF-treated HUVECs (by 75% at 100 mumol/L PDTC).
1	PDTC	Pdtc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	apocynin	apocynin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	SKF	SKF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	52	52	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	by	by	ADP	IN	_	_	_	_	_
23	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	%	%	SYM	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	100	100	NUM	CD	NumType=Card	_	_	_	_
27	mumol	mumol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/L	/L	PROPN	NNP	Number=Sing	_	_	_	_
29	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5768
# text = Inhibition by anti-VCAM-1 monoclonal antibody 1G11 indicated that U937 adhesion was VCAM-1 dependent and suppression by antioxidants was due to reduced VCAM-1 induction.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	anti-VCAM	anti-vcam	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
7	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
8	1G11	1G11	PROPN	NNP	Number=Sing	_	_	_	_
9	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	VCAM	Vcam	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	dependent	dependent	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	due	due	ADP	IN	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5769
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5770
# text = Document 003001450 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001450	003001450	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5771
# text = Reduction of tumour necrosis factor alpha expression and signalling in peripheral blood mononuclear cells from patients with thalassaemia or sickle cell anaemia upon treatment with desferrioxamine.
1	Reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	signalling	signalling	VERB	VBG	VerbForm=Ger	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	thalassaemia	thalassaemia	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	sickle	sickle	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	anaemia	anaemia	NOUN	NN	Number=Sing	_	_	_	_
23	upon	upon	ADP	IN	_	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	desferrioxamine	desferrioxamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5772
# text = Recent evidence indicates that the rate of progression of the HIV-1 disease is significantly reduced in thalassaemia major patients upon treatment with high doses of desferrioxamine (DFX).
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	thalassaemia	thalassaemia	NOUN	NN	Number=Sing	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	upon	upon	ADP	IN	_	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
26	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	desferrioxamine	desferrioxamine	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	DFX	DFX	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5773
# text = The authors have previously demonstrated that in vitro exposure of mononuclear cells to DFX decreases the bioavailability of tumour necrosis factor alpha (TNF-alpha) which has a stimulatory effect on HIV-1 replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	authors	author	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	previously	previously	ADV	RB	_	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
9	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	DFX	DFX	PROPN	NNP	Number=Sing	_	_	_	_
15	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	bioavailability	bioavailability	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
33	on	on	ADP	IN	_	_	_	_	_
34	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5774
# text = In this study, therefore, TNF-alpha bioavailability from mononuclear cells isolated from 10 patients with thalassaemia or sickle cell anaemia given DFX as compared to 10 untreated subjects has been evaluated.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	bioavailability	bioavailability	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	thalassaemia	thalassaemia	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	anaemia	anaemia	ADP	IN	_	_	_	_	_
24	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	DFX	Dfx	NOUN	NN	Number=Sing	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	10	10	NUM	CD	NumType=Card	_	_	_	_
30	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
31	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
32	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5775
# text = Evidence is presented showing that DFX treatment reduces TNF-alpha bioavailability (P<0.05) by inhibiting its steady state (P<0.05) and by enhancing its inactivation through binding to soluble TNF-alpha receptor type II (P<0.05).
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	DFX	DFX	PROPN	NNP	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	bioavailability	bioavailability	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
22	state	state	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
33	through	through	SCONJ	IN	_	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	soluble	soluble	VERB	VB	VerbForm=Inf	_	_	_	_
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
40	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
41	type	type	NOUN	NN	Number=Sing	_	_	_	_
42	II	ii	NUM	CD	NumType=Card	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5776
# text = We also show that DFX treatment limits the in vivo activation of NF-kappaB, a transcription factor involved in both TNF-alpha gene transcription and TNF-alpha signalling (P<0.005).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DFX	DFX	PROPN	NNP	Number=Sing	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	limits	limit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
32	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	0.005	0.005	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5777
# text = We conclude that TNF-alpha bioavailability and signalling are impaired in patients upon DFX treatment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	bioavailability	bioavailability	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	upon	upon	ADP	IN	_	_	_	_	_
15	DFX	Dfx	ADJ	JJ	Degree=Pos	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5778
# text = This mechanism may contribute to delayed progression of the HIV-1 infection in vivo.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	delayed	delayed	VERB	VB	VerbForm=Inf	_	_	_	_
7	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5779
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5780
# text = Document 003001463 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001463	003001463	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5781
# text = Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins.
1	Heterodimerization	Heterodimerization	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5782
# text = The NF-kappa B family of transcription proteins represents multiple DNA binding, rel related polypeptides that contribute to regulation of genes involved in immune responsiveness and inflammation, as well as activation of the HIV long terminal repeat.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	rel	rel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
16	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
17	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
27	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	as	as	ADV	RB	_	_	_	_	_
32	well	well	ADV	RB	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
38	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
39	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
40	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5783
# text = In this study multiple NF-kappa B related polypeptides ranging from 85 to 45 kDa were examined for their capacity to interact with the PRDII regulatory element of interferon beta and were shown to possess distinct intrinsic DNA binding affinities for this NF-kappa B site and form multiple DNA binding homo- and heterodimer complexes in co-renaturation experiments.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
10	polypeptides	polypeptides	NOUN	NNS	Number=Plur	_	_	_	_
11	ranging	range	VERB	VBG	VerbForm=Ger	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	85	85	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	45	45	NUM	CD	NumType=Card	_	_	_	_
16	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	PRDII	pRDIi	X	AFX	_	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	possess	possess	VERB	VB	VerbForm=Inf	_	_	_	_
37	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
38	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
47	B	b	NOUN	NN	Number=Sing	_	_	_	_
48	site	site	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	form	form	ADJ	JJ	Degree=Pos	_	_	_	_
51	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
52	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
53	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
54	homo	homo	ADV	RB	_	_	_	_	SpaceAfter=No
55	-	-	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
58	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	co-renaturation	co-renaturation	NOUN	NN	Number=Sing	_	_	_	_
61	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5784
# text = Furthermore, using DNA templates containing two copies of the PRDII domain linked to the rabbit beta globin gene, the purified polypeptides specifically stimulated NF-kappa B dependent transcription in an in vitro reconstitution assay as heterodimers but not as p50 homodimers.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	templates	template	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	PRDII	PRDII	PROPN	NNP	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	globin	globin	ADP	IN	_	_	_	_	_
19	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
24	specifically	specifically	ADV	RB	_	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
36	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	_
37	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	not	not	ADV	RB	_	_	_	_	_
42	as	as	ADV	RB	_	_	_	_	_
43	p50	p50	NUM	CD	NumType=Card	_	_	_	_
44	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5785
# text = These experiments emphasize the role of NF-kappa B dimerization as a distinct level of transcriptional control that may permit functional diversification of a limited number of regulatory proteins.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	emphasize	emphasize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	permit	permit	VERB	VB	VerbForm=Inf	_	_	_	_
22	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
23	diversification	diversification	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
27	number	number	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5786
# text = Document 003001467 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001467	003001467	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5787
# text = A nuclear factor NF-GM2 that interacts with a regulatory region of the GM-CSF gene essential for its induction in responses to T-cell activation: purification from human T-cell leukemia line Jurkat cells and similarity to NF-kappa B. Activation of T cells by antigen, lectin, or a combination of phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) leads to the induction of genes for a set of lymphokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	purification	purification	NOUN	NN	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
36	line	line	NOUN	NN	Number=Sing	_	_	_	_
37	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
45	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
46	Activation	Activation	PROPN	NNP	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	T	t	PROPN	NNP	Number=Sing	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	or	or	CCONJ	CC	_	_	_	_	_
56	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
57	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
64	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	_
68	and	and	CCONJ	CC	_	_	_	_	_
69	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
70	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
71	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
72	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
73	)	)	PUNCT	-RRB-	_	_	_	_	_
74	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
75	to	to	ADP	IN	_	_	_	_	_
76	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
77	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
78	of	of	ADP	IN	_	_	_	_	_
79	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
80	for	for	ADP	IN	_	_	_	_	_
81	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
82	set	set	NOUN	NN	Number=Sing	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	lymphokines	lymphokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
87	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
89	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
90	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
91	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
92	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
93	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
94	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
95	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
96	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
97	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
98	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
99	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5788
# text = We demonstrated in earlier studies that the upstream region of the mouse GM-CSF promoter at positions between -95 and -73 is essential for transcriptional activation in response to PMA/A23187.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
13	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	-95	-95	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	73	73	NUM	CD	NumType=Card	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	PMA/A	PMA/A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	23187	23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5789
# text = This region contains two DNA-binding motifs, GM2 and GC-box.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	GM2	GM2	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	GC	Gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5790
# text = The GM2 sequence (GGTAGTTCCC) is recognized by an inducible factor NF-GM2; the other (CCGCCC) by constitutive factors A1, A2, and B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM2	Gm2	NUM	CD	NumType=Card	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	GGTAGTTCCC	GGTAGTTCCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	CCGCCC	CCGCCC	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	A1	A1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	A2	A2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5791
# text = To elucidate the mechanism of GM-CSF gene activation, we have purified the inducible factor NF-GM2 from the nuclear extract of stimulated Jurkat cells on the basis of specific DNA-binding activity.
1	To	to	PART	TO	_	_	_	_	_
2	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5792
# text = The purified NF-GM2 consists of 50 (p50) and 65 kDa (p65) polypeptides and has a binding activity specific for both the GM-CSF and immunoglobulin kappa (GGAAAGTCCC) enhancers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
6	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	50	50	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	65	65	NUM	CD	NumType=Card	_	_	_	_
14	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	both	both	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	GM	gm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CSF	Csf	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	immunoglobulin	immunoglobulin	PROPN	NNP	Number=Sing	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	GGAAAGTCCC	Ggaaagtccc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5793
# text = Electrophoretically purified p50 alone can form a protein-DNA complex, but in the mixture, p50 associates preferentially with p65 to form the NF-GM2 complex.
1	Electrophoretically	Electrophoretically	ADV	RB	_	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
4	alone	alone	ADV	RB	_	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	p50	p50	NUM	CD	NumType=Card	_	_	_	_
19	associates	associate	NOUN	NNS	Number=Plur	_	_	_	_
20	preferentially	preferentially	ADV	RB	_	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5794
# text = In addition, p65 gave per se, with low affinity, a protein-DNA complex that migrated more slowly than native NF-GM2 complex.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	p65	p65	NUM	CD	NumType=Card	_	_	_	_
5	gave	give	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	per	per	ADP	IN	_	_	_	_	_
7	se	se	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
11	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	migrated	migrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	slowly	slowly	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	GM2	Gm2	NUM	CD	NumType=Card	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5795
# text = Furthermore, an antiserum against KBF1 (identical to 50 kDa NF-kappa B protein) reacted with the p50 of NF-GM2, indicating that the NF-GM2 polypeptide cannot be immunologically differentiated from the 50 kDa subunit of NF-kappa B.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
5	against	against	ADP	IN	_	_	_	_	_
6	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	50	50	NUM	CD	NumType=Card	_	_	_	_
11	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
15	B	b	X	GW	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	reacted	react	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
33	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
35	not	not	PART	RB	_	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	immunologically	immunologically	ADV	RB	_	_	_	_	_
38	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	50	50	NUM	CD	NumType=Card	_	_	_	_
42	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
43	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
48	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5796
# text = The purified NF-GM2 activated in vitro transcription from the kappa B enhancer, while it failed to stimulate transcription from the GM-CSF promoter harboring the GM2 sequence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	harboring	harbor	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
31	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5797
# text = This suggests that the activation mechanism of the GM-CSF gene through the GM2/GC-box sequence is different from that of genes carrying the kappa B enhancer alone.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
12	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM2/GC	Gm2/gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5798
# text = Document 003001482 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001482	003001482	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5799
# text = Retinoic acid-induced modulation of IL-2 mRNA production and IL-2 receptor expression on T cells.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-induced	-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5800
# text = BACKGROUND: Retinoic acid (RA) has important immune-modulating effects on both T and B cell function.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
4	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-modulating	-modulating	NOUN	NN	Number=Sing	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	T	t	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5801
# text = Our laboratory has shown that RA can enhance in vitro polyclonal B cell immunoglobulin
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
11	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5802
# text = (Ig) response.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5803
# text = Investigating cytokines known to affect B cell differentiation, we have recently shown that IL-6 production is augmented by RA.
1	Investigating	investigate	VERB	VBG	VerbForm=Ger	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	affect	affect	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5804
# text = In the present study we have examined the immune modulating effects of RA on IL-2 mRNA, another important cytokine for B cell immunoglobulin production, the expression of IL-2 receptors on T cells, and the RA nuclear receptors.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	modulating	modulating	NOUN	NN	Number=Sing	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	another	another	DET	DT	_	_	_	_	_
21	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
36	on	on	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5805
# text = METHODS: Purified T cells were obtained from adenoidal tissues, and incubated with RA (10(-7) M) or DMSO solvent/media control for 0, 6-8, and 24 h.
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Purified	Purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	adenoidal	adenoidal	ADJ	JJ	Degree=Pos	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
19	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	DMSO	Dmso	PROPN	NNP	Number=Sing	_	_	_	_
25	solvent	solvent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	media	media	NOUN	NN	Number=Sing	_	_	_	_
28	control	control	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	0	0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	24	24	NUM	CD	NumType=Card	_	_	_	_
38	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5806
# text = Total mRNA was extracted from T cells, and using RT-PCR, changes in the production of IL-2 and RA receptors (RAR)-alpha,beta,gamma mRNA were determined.
1	Total	total	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
11	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	PCR	Pcr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
34	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
35	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	determined	determine	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5807
# text = The effects of RA on IL-2-alpha receptor expression was determined by flow cytometry on T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
17	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5808
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 5809
# text = These studies suggest that RA can augment IL-2 mRNA production by T cells with a possible paracrine effect on IL-2R-alpha expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
19	paracrine	paracrine	NOUN	NN	Number=Sing	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	IL-	IL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	2R	2r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5810
# text = These changes appear to be mediated by RAR-alpha.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
3	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	RAR-	rar-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5811
# text = Thus, IL-2 may be another important cytokine modulated by RA in the immune response.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	another	another	DET	DT	_	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5812
# text = Document 003001483 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001483	003001483	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5813
# text = Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	involves	involves	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein.	protein.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 5814
# text = Interleukin-3 (IL-3) is exclusively expressed by activated T and natural killer cells, a function that is tightly controlled both in a lineage-specific and in a stimulation-dependent manner.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	exclusively	exclusively	ADV	RB	_	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
17	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	tightly	tightly	ADV	RB	_	_	_	_	_
25	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	both	both	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5815
# text = We have investigated the protein binding characteristics and functional importance of the ACT-1-activating region of the IL-3 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ACT	act	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5816
# text = This region binds an inducible, T-cell-specific factor over its 5' end, a site that is necessary for the expression of IL-3 in the absence of other upstream elements.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	over	over	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	_
16	end	end	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	3	3	NUM	CD	NumType=Card	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
35	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
36	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5817
# text = Over its 3' end, it binds a factor that is ubiquitously and constitutively expressed.
1	Over	over	ADP	IN	_	_	_	_	_
2	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	``	_	_	_	_	_
5	end	end	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	constitutively	constitutively	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5818
# text = This factor is Oct-1 or an immunologically related octamer-binding protein, and it plays a role in coordinating the activity of several regulatory elements.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	immunologically	immunologically	ADV	RB	_	_	_	_	_
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	octamer-binding	octamer-binding	ADJ	JJ	Degree=Pos	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	coordinating	coordinate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5819
# text = These characteristics make the ACT-1 site analogous to the activating ARRE-1 site in the IL-2 promoter.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
3	make	make	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ACT	act	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
13	ARRE	Arre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5820
# text = Furthermore, and despite a lack of sequence homology, the promoters of IL-3 and IL-2 share an organizational pattern of regulatory elements that is likely to be important for the T-cell-specific expression of these genes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	despite	despite	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	homology	homology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	share	share	NOUN	NN	Number=Sing	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	organizational	organizational	ADJ	JJ	Degree=Pos	_	_	_	_
24	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5821
# text = Document 003001485 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001485	003001485	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5822
# text = IL-1 receptor and TCR signals synergize to activate NF-kappa B-mediated gene transcription.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5823
# text = Previous studies have demonstrated that IL-1 receptor (IL-1R)- and TCR-initiated signals can interact synergistically to increase the rate of transcription of several lymphokine and lymphokine receptor genes during the competence phase of the activation program in T helper lymphocytes.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL-1R	Il-1r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
21	synergistically	synergistically	ADV	RB	_	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
30	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
35	during	during	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	competence	competence	NOUN	NN	Number=Sing	_	_	_	_
38	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	program	program	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
46	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5824
# text = In this report we describe how signals initiated through the type I IL-1R interact with signals from the antigen receptor to synergistically augment the transactivating properties of NF-kappa B.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	how	how	ADV	WRB	PronType=Int	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1R	1r	PROPN	NNP	Number=Sing	_	_	_	_
16	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	synergistically	synergistically	ADV	RB	_	_	_	_	_
25	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5825
# text = The synergistic antigen receptor initiated signals are mediated through protein kinase C because they can be mimicked by the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, but not with calcium ionophores; and are staurosporine sensitive but cyclosporine resistant.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
3	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	C	care	NOUN	NN	Number=Sing	_	_	_	_
13	because	because	SCONJ	IN	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
21	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
24	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-acetate	-acetate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
31	ionophores	ionophore	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	;	;	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	staurosporine	staurosporine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	cyclosporine	cyclosporine	ADJ	JJ	Degree=Pos	_	_	_	_
39	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5826
# text = Gel shift analyses demonstrate that NF-kappa B nuclear translocation is stimulated primarily by IL-1 rather than by antigen receptor signals.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	primarily	primarily	ADV	RB	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	rather	rather	ADV	RB	_	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	antigen	antigen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5827
# text = Western blot and phosphorylation analyses demonstrate that the synergistic effect on NF-kappa B functional activity is independent of I kappa B alpha (MAD3)-NF-kappa B dissociation in the cytosol and is not associated with I kappa B nuclear translocation.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MAD3	MAD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	not	not	PART	RB	_	_	_	_	_
40	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
43	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
44	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
45	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
46	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5828
# text = The IL-1-induced NF-kappa B DNA nuclear localization is transient and can be prolonged either by an antigen receptor-initiated signal or by inhibiting protein synthesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	DNA	dna	PROPN	NNP	Number=Sing	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	either	either	CCONJ	CC	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-initiated	-initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	by	by	SCONJ	IN	_	_	_	_	_
29	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5829
# text = These results suggest that IL-1 induces both NF-kappa B nuclear translocation and the synthesis of a protein(s) responsible for terminating NF-kappa B-DNA interaction in the nucleus.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	s	s	X	AFX	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	terminating	terminating	VERB	VBG	VerbForm=Ger	_	_	_	_
28	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5830
# text = Antigen receptor signals prolong NF-kappa B-DNA interaction, probably by functionally antagonizing the IL-1-induced synthesis of a protein(s) responsible for the transient NF-kappa B-DNA interaction and consequently synergistically enhance IL-1-induced NF-kappa B-dependent gene transcription.
1	Antigen	Antigen	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
4	prolong	prolong	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	probably	probably	ADV	RB	_	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	functionally	functionally	ADV	RB	_	_	_	_	_
16	antagonizing	antagonize	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	s	s	X	AFX	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	consequently	consequently	ADV	RB	_	_	_	_	_
43	synergistically	synergistically	ADV	RB	_	_	_	_	_
44	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	_
45	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
53	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
56	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
57	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5831
# text = Document 003001490 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001490	003001490	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5832
# text = The DNA binding domain of the A-MYB transcription factor is responsible for its B cell-specific activity and binds to a B cell 110-kDa nuclear protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	MYB	Myb	PROPN	NNP	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	110	110	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5833
# text = Expression studies as well as the use of transgenic animals have demonstrated that the A-MYB transcription factor plays central and specific role in the regulation of mature B cell proliferation and/or differentiation.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	as	as	ADV	RB	_	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	use	use	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
10	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	MYB	Myb	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	role	role	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	or	or	CCONJ	CC	_	_	_	_	_
36	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5834
# text = Furthermore, it is highly expressed in Burkitt's lymphoma cells and may participate in the pathogenesis of this disease.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	highly	highly	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	's	's	PART	POS	_	_	_	_	_
10	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5835
# text = We have therefore investigated the transcriptional activity of A-MYB and its regulation in several human lymphoid cell lines using co-transfection assays and show that A-MYB is transcriptionally active in all the B cell lines studied, but not in T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	MYB	MYB	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
23	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	MYB	MYB	PROPN	NNP	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
32	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	all	all	DET	PDT	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
39	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	not	not	ADV	RB	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5836
# text = In particular the best responder cell line was the Burkitt's cell line Namalwa.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
5	responder	responder	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	's	's	PART	POS	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	_
14	Namalwa	Namalwa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5837
# text = The activity of A-MYB in B and not T cells was observed when either an artificial construct or the c-MYC promoter was used as a reporter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	MYB	MYB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	artificial	artificial	ADJ	JJ	Degree=Pos	_	_	_	_
19	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	MYC	Myc	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5838
# text = Furthermore, the functional domains responsible for DNA binding, transactivation, and negative regulation, previously characterized in a fibroblast context, were found to have similar activity in B cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
6	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	previously	previously	ADV	RB	_	_	_	_	_
18	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
22	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
28	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5839
# text = The region of A-MYB responsible for the B cell specific activity was defined to be the N-terminal 218 amino acids containing the DNA binding domain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	MYB	MYB	PROPN	NNP	Number=Sing	_	_	_	_
7	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
21	218	218	NUM	CD	NumType=Card	_	_	_	_
22	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
23	acids	acid	SCONJ	IN	_	_	_	_	_
24	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
28	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5840
# text = Finally, a 110-kDa protein has been identified in the nuclei of all the B, but not T, cell lines that specifically binds to this A-MYB N-terminal domain.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	110	110	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	all	all	DET	PDT	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	specifically	specifically	ADV	RB	_	_	_	_	_
27	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	MYB	Myb	NOUN	NN	Number=Sing	_	_	_	_
33	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
35	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5841
# text = We hypothesize that this 110-kDa protein may be a functionally important B cell-specific co-activator of A-MYB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesize	hypothesize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	110	110	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	functionally	functionally	ADV	RB	_	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	co-activator	co-activator	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	MYB	MYB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5842
# text = Document 003001494 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001494	003001494	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5843
# text = The normal cell cycle activation program is exploited during the infection of quiescent B lymphocytes by Epstein-Barr virus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	program	program	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	exploited	exploit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5844
# text = B lymphocytes in the peripheral circulation are maintained in a non-proliferative state.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	circulation	circulation	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	non-proliferative	non-proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5845
# text = Antigen recognition stimulates limited proliferation, whereas infection with Epstein-Barr virus (EBV) results in continual proliferation and the outgrowth of immortal cell lines.
1	Antigen	Antigen	ADJ	JJ	Degree=Pos	_	_	_	_
2	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
3	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
5	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	whereas	whereas	SCONJ	IN	_	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	results	result	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	continual	continual	ADJ	JJ	Degree=Pos	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	immortal	immortal	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5846
# text = Because it is not clear at which point in cell cycle the peripheral B lymphocytes are arrested, we characterized the expression of several cell cycle-associated genes in quiescent and stimulated cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	which	which	DET	WDT	PronType=Int	_	_	_	_
8	point	point	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	arrested	arrest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5847
# text = We show that the expression of four cell genes, cdc-2, cyclin E, CD23, and cyclin D2, are up-regulated approximately 100-fold as a result of EBV-mediated immortalization.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	four	four	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	cdc	cdc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
16	E	e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
22	D2	d2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	approximately	approximately	ADV	RB	_	_	_	_	_
29	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	result	result	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5848
# text = Because these genes play a positive role in cell proliferation, we suggest that this regulatory switch contributes to controlling entry into the cell cycle.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
18	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	controlling	controlle	VERB	VB	VerbForm=Inf	_	_	_	_
21	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
22	into	into	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5849
# text = Transient stimulation of quiescent B lymphocytes with either a cocktail of anti-CD40, anti-IgM, and IL4, or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of B-lymphocyte cell cycle activation.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	either	either	CCONJ	CC	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cocktail	cocktail	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	anti-IgM	anti-Igm	INTJ	UH	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	IL4	IL4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
21	results	result	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
29	four	four	NUM	CD	NumType=Card	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
39	exploits	exploit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
42	program	program	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
49	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5850
# text = Document 003001496 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001496	003001496	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5851
# text = Anti-Ehrlichia chaffeensis antibody complexed with E.
1	Anti-Ehrlichia	Anti-Ehrlichia	PROPN	NNP	Number=Sing	_	_	_	_
2	chaffeensis	chaffeensis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
4	complexed	complex	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5852
# text = chaffeensis induces potent proinflammatory cytokine mRNA expression in human monocytes through sustained reduction of IkappaB-alpha and activation of NF-kappaB.
1	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
2	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
3	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
4	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
6	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5853
# text = Ehrlichia chaffeensis is an obligatory intracellular bacterium that infects monocytes and macrophages and is the etiologic agent of human ehrlichiosis in the United States.
1	Ehrlichia	Ehrlichia	PROPN	NNP	Number=Sing	_	_	_	_
2	chaffeensis	chaffeensis	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	obligatory	obligatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	bacterium	bacterium	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
17	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	ehrlichiosis	ehrlichiosis	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	United	United	PROPN	NNP	Number=Sing	_	_	_	_
24	States	States	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5854
# text = Our previous studies showed that the exposure of human monocytes to E.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5855
# text = chaffeensis induces the expression of interleukin-1beta (IL-1beta), IL-8, and IL-10 genes in vitro but not the expression of tumor necrosis factor alpha (TNF-alpha) and IL-6 mRNAs.
1	chaffeensis	chaffeensis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	10	10	NUM	CD	NumType=Card	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
33	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
44	6	6	NUM	CD	NumType=Card	_	_	_	_
45	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5856
# text = In this study, the effect of anti-E. chaffeensis antibody complexed with E. chaffeensis on the expression of major proinflammatory cytokines in human monocytes was examined.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	anti-E.	anti-E.	ADJ	JJ	Degree=Pos	_	_	_	_
9	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
10	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
11	complexed	complex	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_
14	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
20	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5857
# text = Human monocytic cell line THP-1 was treated with E.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	line	line	NOUN	NN	Number=Sing	_	_	_	_
5	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5858
# text = chaffeensis which had been preincubated with human anti-E. chaffeensis serum for 2 h, and the levels of cytokine mRNAs were evaluated by competitive reverse transcription-PCR.
1	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
2	which	which	PRON	WDT	PronType=Rel	_	_	_	_
3	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	anti-E.	anti-E.	ADJ	JJ	Degree=Pos	_	_	_	_
9	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
10	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
25	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5859
# text = Anti-E. chaffeensis antibody complexed with E. chaffeensis significantly enhanced mRNA expression of IL-1beta in THP-1 cells.
1	Anti-E.	Anti-e.	ADJ	JJ	Degree=Pos	_	_	_	_
2	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
3	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
4	complexed	complex	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_
7	chaffeensis	chaffeensis	PROPN	NNPS	Number=Plur	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5860
# text = The expression of TNF-alpha and IL-6 mRNAs was also induced.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5861
# text = The levels of secreted IL-1beta, TNF-alpha, and IL-6 during 24 h of stimulation were comparable to those induced by Escherichia coli lipopolysaccharide at 1 microg/ml.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	_
20	h	h	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
30	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
31	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	microg	microg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5862
# text = Fab fragment of anti-E. chaffeensis immunoglobulin
1	Fab	Fab	ADJ	JJ	Degree=Pos	_	_	_	_
2	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anti-E.	anti-E.	ADJ	JJ	Degree=Pos	_	_	_	_
5	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
6	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5863
# text = G complexed with E.
1	G	g	NOUN	NN	Number=Sing	_	_	_	_
2	complexed	complex	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5864
# text = chaffeensis did not induce any of these three cytokines, indicating that ehrlichial binding is required for IL-1beta mRNA expression and that binding of the immune complex to the Fc gamma receptor is required for TNF-alpha and IL-6 mRNA expression and enhanced IL-1beta mRNA expression.
1	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
2	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
5	any	any	DET	DT	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	ehrlichial	ehrlichial	ADJ	JJ	Degree=Pos	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	bet	bet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
31	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
35	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	6	6	NUM	CD	NumType=Card	_	_	_	_
47	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
55	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5865
# text = Furthermore, prolonged degradation of IkappaB-alpha and activation of NF-kappaB were demonstrated in THP-1 cells exposed to anti-E. chaffeensis serum and E. chaffeensis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	prolonged	prolong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	anti-E.	anti-E.	ADJ	JJ	Degree=Pos	_	_	_	_
25	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
26	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	E.	e.	PROPN	NNP	Number=Sing	_	_	_	_
29	chaffeensis	chaffeensis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5866
# text = This result implies that development of anti-E. chaffeensis antibody in patients can result in the production of major proinflammatory cytokines, which may play an important role in the pathophysiology of ehrlichiosis and immune responses to it.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	implies	imply	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	development	development	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	anti-E.	anti-E.	ADJ	JJ	Degree=Pos	_	_	_	_
8	chaffeensis	chaffeensis	NOUN	NN	Number=Sing	_	_	_	_
9	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	ehrlichiosis	ehrlichiosis	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
35	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5867
# text = Document 003001497 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001497	003001497	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5868
# text = Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	AT	AT	ADV	RB	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5869
# text = Activation of individual CD4+ T cells results in differential lymphokine expression: interleukin 2 (IL-2) is preferentially produced by T helper type 1 (TH1) cells, which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells, which are essential for humoral immunity.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	preferentially	preferentially	ADV	RB	_	_	_	_	_
23	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
27	type	type	NOUN	NN	Number=Sing	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TH1	TH1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	immune	immune	NOUN	NN	Number=Sing	_	_	_	_
42	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	whereas	whereas	SCONJ	IN	_	_	_	_	_
45	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	4	4	NUM	CD	NumType=Card	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	TH2	TH2	NUM	CD	NumType=Card	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	which	which	PRON	WDT	PronType=Rel	_	_	_	_
55	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	humoral	humoral	ADJ	JJ	Degree=Pos	_	_	_	_
59	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5870
# text = The Ca(2+)-dependent factor NF-ATp plays a key role in the inducible transcription of both these lymphokine genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5871
# text = However, while IL2 expression requires the contribution of Ca(2+)- and protein kinase C-dependent signals, we report that activation of human IL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in Jurkat T cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	IL2	IL2	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+)	+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	IL4	IL4	NUM	CD	NumType=Card	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	through	through	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
44	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
45	C	c	NOUN	NN	Number=Sing	_	_	_	_
46	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5872
# text = This phenomenon is due to mutually exclusive binding of NF-ATp and NF-kappa B to the P sequence, an element located 69 bp upstream of the IL4 transcription initiation site.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	due	due	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	mutually	mutually	ADV	RB	_	_	_	_	_
7	exclusive	exclusive	VERB	VB	VerbForm=Inf	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	P	P	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	69	69	NUM	CD	NumType=Card	_	_	_	_
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL4	IL4	PROPN	NNP	Number=Sing	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5873
# text = Human IL4 promoter-mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B-activating cytokine tumor necrosis factor alpha and suppressed in RelA-overexpressing cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	IL4	IL4	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	overexpressing	overexpresse	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5874
# text = In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence, which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	C	C	NOUN	NN	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
10	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	IL4	Il4	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	P	p	NOUN	NN	Number=Sing	_	_	_	_
25	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
43	site	site	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5875
# text = Thus, competition between two general transcriptional activators, RelA and NF-ATp, mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	C	c	NOUN	NN	Number=Sing	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	IL4	IL4	NUM	CD	NumType=Card	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	differential	differential	VERB	VB	VerbForm=Inf	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	TH	th	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5876
# text = Document 003001505 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001505	003001505	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5877
# text = Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB-inducing	kappaB-inducing	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
32	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
33	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5878
# text = The Epstein-Barr virus oncoprotein latent infection membrane protein 1 (LMP1) is a constitutively aggregated pseudo-tumor necrosis factor receptor (TNFR) that activates transcription factor NF-kappaB through two sites in its C-terminal cytoplasmic domain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	_
7	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	constitutively	constitutively	ADV	RB	_	_	_	_	_
18	aggregated	aggregate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	pseudo	pseudo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	through	through	ADP	IN	_	_	_	_	_
36	two	two	NUM	CD	NumType=Card	_	_	_	_
37	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
42	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
43	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5879
# text = One site is similar to activated TNFRII in associating with TNFR-associated factors TRAF1 and TRAF2, and the second site is similar to TNFRI in associating with the TNFRI death domain interacting protein TRADD.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	TNFRII	TNFRII	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	associating	associat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	TRAF1	TRAF1	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	TNFRI	TNFRI	PROPN	NNP	Number=Sing	_	_	_	_
27	in	in	SCONJ	IN	_	_	_	_	_
28	associating	associate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	TNFRI	TNFRI	PROPN	NNP	Number=Sing	_	_	_	_
32	death	death	NOUN	NN	Number=Sing	_	_	_	_
33	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
34	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5880
# text = TNFRI has been recently shown to activate NF-kappaB through association with TRADD, RIP, and TRAF2; activation of the NF-kappaB-inducing kinase (NIK); activation of the IkappaB alpha kinases (IKKalpha and IKKbeta); and phosphorylation of IkappaB alpha.
1	TNFRI	TNFRI	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	recently	recently	ADV	RB	_	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	association	association	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	RIP	rip	INTJ	UH	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	TRAF2	TRAF2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	;	;	PUNCT	,	_	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	;	;	PUNCT	,	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
50	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5881
# text = IkappaB alpha phosphorylation on Ser-32 and Ser-36 is followed by its degradation and NF-kappaB activation.
1	IkappaB	Ikappab	X	LS	_	_	_	_	_
2	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	Ser	Ser	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-32	-32	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Ser	Ser	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-36	-36	NUM	CD	NumType=Card	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5882
# text = In this report, we show that NF-kappaB activation by LMP1 or by each of its effector sites is mediated by a pathway that includes NIK, IKKalpha, and IKKbeta.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	each	each	DET	DT	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5883
# text = Dominant negative mutants of NIK, IKKalpha, or IKKbeta substantially inhibited NF-kappaB activation by LMP1 or by each of its effector sites.
1	Dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
3	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
11	substantially	substantially	ADV	RB	_	_	_	_	_
12	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	each	each	DET	DT	_	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5884
# text = Document 003001507 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001507	003001507	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5885
# text = Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	S	S	NOUN	NN	Number=Sing	_	_	_	_
18	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5886
# text = It is becoming increasingly apparent that NF-kappa B plays a critical role in regulating the inflammatory response.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	becoming	become	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	increasingly	increasingly	ADV	RB	_	_	_	_	_
5	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5887
# text = Data obtained from studies in our laboratories demonstrate that the proteasome plays an important role in the inflammatory cascade by regulating the activation of NF-kappa B.
1	Data	data	PROPN	NNP	Number=Sing	_	_	_	_
2	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
7	laboratories	laboratory	NOUN	NNS	Number=Plur	_	_	_	_
8	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5888
# text = Indeed, the availability of selective and orally active proteasome inhibitors should prove useful in delineating the roles of the proteasome and NF-kappa B in other pathophysiological conditions such as cancer and heart disease.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	orally	orally	ADV	RB	_	_	_	_	_
9	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
12	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
13	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
14	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	delineating	delineat	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
29	pathophysiological	pathophysiological	ADJ	JJ	Degree=Pos	_	_	_	_
30	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
31	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	heart	heart	NOUN	NN	Number=Sing	_	_	_	_
36	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5889
# text = Document 003001511 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001511	003001511	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5890
# text = Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	bare	bear	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
10	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
23	box	box	NOUN	NN	Number=Sing	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5891
# text = CIITA is a positive regulator of class II major histocompatibility complex gene transcription that has been found to be defective in one of the five complementation groups of class II major histocompatibility complex-negative cell lines.
1	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	five	five	NUM	CD	NumType=Card	_	_	_	_
26	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
27	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	class	class	NOUN	NN	Number=Sing	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
32	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
33	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5892
# text = Its N-terminal region is capable of activating transcription from a reporter gene when fused to a DNA binding domain.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
2	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
8	of	of	SCONJ	IN	_	_	_	_	_
9	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	fused	fuse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5893
# text = We have investigated the mechanism of transactivation mediated by the CIITA activation domain by studying its role in the process of transcription initiation and elongation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
17	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	process	process	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5894
# text = Specifically the altered specificity TBP (TATA box binding protein) assay has been used to analyze the response of the CIITA activation domain to mutations in TBP known to disrupt its interaction with its associated general factors.
1	Specifically	specifically	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	altered	alter	ADJ	JJ	Degree=Pos	_	_	_	_
4	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
5	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	TBP	TBP	PROPN	NNP	Number=Sing	_	_	_	_
29	known	known	PROPN	NNP	Number=Sing	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
32	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
38	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5895
# text = Transactivation by CIITA was extremely sensitive to a mutation in TBP that in yeast is known to abolish VP16-mediated transcription but leaves basal transcription unaffected.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	extremely	extremely	ADV	RB	_	_	_	_	_
6	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	TBP	TBP	PROPN	NNP	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	abolish	abolish	VERB	VB	VerbForm=Inf	_	_	_	_
19	VP	VP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	leaves	leave	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5896
# text = A TBP mutant defective in interaction with TBP-associated factor TAFII250 also failed to mediate transactivation through the CIITA activation domain.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	TBP	TBP	NOUN	NN	Number=Sing	_	_	_	_
3	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
4	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	TBP	TBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	TAFII250	TAFII250	NUM	CD	NumType=Card	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
17	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5897
# text = Certain interactions between TBP and general factors that are specifically required for acidic activation domains were also required for CIITA-mediated transactivation to reach its full potential.
1	Certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
2	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	specifically	specifically	ADV	RB	_	_	_	_	_
11	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	reach	reach	VERB	VB	VerbForm=Inf	_	_	_	_
26	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
27	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
29	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5898
# text = Finally, like VP16, CIITA was able to stimulate elongation of transcription.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	like	like	ADP	IN	_	_	_	_	_
4	VP16	VP16	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5899
# text = Overall the mechanism of transactivation by the human B-cell-specific CIITA is very similar to that mediated by the herpes virus transactivator VP16 in the ways that have been tested.
1	Overall	overall	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	very	very	ADV	RB	_	_	_	_	_
16	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	herpes	herpe	NOUN	NN	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
25	VP	vp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	16	16	NUM	CD	NumType=Card	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	ways	way	NOUN	NNS	Number=Plur	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5900
# text = Document 003001513 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001513	003001513	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5901
# text = Transactivation of the human immunodeficiency virus promoter by human herpesvirus 6 (HHV-6) strains GS and Z-29 in primary human T lymphocytes and identification of transactivating HHV-6(GS) gene fragments.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	HHV	Hhv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	strains	strain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	GS	GS	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Z	Z	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	29	29	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
32	HHV	HHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	GS	GS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5902
# text = Human herpesvirus 6 (HHV-6) can activate the human immunodeficiency virus (HIV) promoter and accelerate cytopathic effects in HIV-infected human T cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	HHV	Hhv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	accelerate	accelerate	VERB	VB	VerbForm=Inf	_	_	_	_
21	cytopathic	cytopathic	ADJ	JJ	Degree=Pos	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5903
# text = This study examines the regions of the HIV promoter required for HHV-6 transactivation in a heterogeneous population of primary human T lymphocytes with or without antigenic stimulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	examines	examine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	HHV	HHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
19	population	population	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	T	PROPN	NNP	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	without	without	ADP	IN	_	_	_	_	_
28	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5904
# text = Two different strains of HHV-6, GS and Z29, transactivated the HIV promoter.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	strains	strains	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HHV	HHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	GS	GS	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Z29	Z29	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	transactivated	transactivate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5905
# text = The GS strain transactivated the promoter in both stimulated and resting T cells, while the Z29 strain increased HIV promoter activity only in stimulated T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GS	GS	PROPN	NNP	Number=Sing	_	_	_	_
3	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
4	transactivated	transactivate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	Z29	Z29	PROPN	NNP	Number=Sing	_	_	_	_
18	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	only	only	ADV	RB	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	stimulated	stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5906
# text = Three DNA clones containing HHV-6(GS) genomic fragments transactivated the HIV promoter in cotransfected T cells.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	HHV	HHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	GS	GS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
12	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
13	transactivated	transactivate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5907
# text = A 21.4-kb DNA clone, pZVB70, showed the highest transactivating ability, while two other DNA fragments, pZVB10 (6.2 kb) and pZVH14 (8.7 kb), showed lower activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	21.4	21.4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	pZVB70	pZVB70	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
13	transactivating	transactivating	NOUN	NN	Number=Sing	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	pZVB	pzvb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	10	10	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	6.2	6.2	NUM	CD	NumType=Card	_	_	_	_
26	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	pZVH14	pZVH14	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	8.7	8.7	NUM	CD	NumType=Card	_	_	_	_
32	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5908
# text = One of these clones, pZVH14, activated the HIV promoter construct containing a mutation in the NF kappa B site.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	pZVH14	pZVH14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	B	PROPN	NNP	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5909
# text = However, this mutated NF kappa B promoter was not transactivated during HHV-6(GS) infection or after cotransfection with pZVB70 or pZVB10.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	mutated	mutate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	HHV	HHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	GS	GS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	pZVB70	pZVB70	NUM	CD	NumType=Card	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	pZVB	pzvb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5910
# text = These data indicate that the NF kappa B sites of the HIV promoter are essential for its transactivation during HHV-6(GS) infection.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	HHV	HHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	GS	GS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5911
# text = By increasing HIV promoter activity in primary T lymphocytes, HHV-6 may consequently increase HIV replication, leading to an increase in the cytopathic effect on coinfected human T cells.
1	By	by	SCONJ	IN	_	_	_	_	_
2	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	HHV	HHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	consequently	consequently	ADV	RB	_	_	_	_	_
16	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
18	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	cytopathic	cytopathic	ADJ	JJ	Degree=Pos	_	_	_	_
27	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	coinfected	coinfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5912
# text = Document 003001514 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001514	003001514	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5913
# text = HIV1 infection of human monocytes and macrophages promotes induction or translocation of NF-KB-related factors.
1	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	KB	KB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5914
# text = In 1991, we demonstrated, using electrophoretic mobility shift assays, that 3 different factors (termed B1, B2 and B3) with affinity for the KB-enhancer target sequence were specifically detected in nuclear extracts from HIV1-infected monocytes and macrophages.
1	In	in	ADP	IN	_	_	_	_	_
2	1991	1991	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
9	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
10	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
11	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	B1	b1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	B2	b2	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	B3	B3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	KB	KB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	target	target	NOUN	NN	Number=Sing	_	_	_	_
33	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	specifically	specifically	ADV	RB	_	_	_	_	_
36	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5915
# text = The B2 factor was induced in the nuclei of these cells only upon HIV1 infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B2	b2	NUM	CD	NumType=Card	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	upon	upon	ADP	IN	_	_	_	_	_
14	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	_
15	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5916
# text = The B3 factor was only slightly evident in nuclei of uninfected cells but was readily detectable in nuclei of infected monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B3	B3	NUM	CD	NumType=Card	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	_
6	slightly	slightly	ADV	RB	_	_	_	_	_
7	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	readily	readily	ADV	RB	_	_	_	_	_
16	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5917
# text = Its expression remained very low in nuclei of HIV1-infected macrophages.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	very	very	ADV	RB	_	_	_	_	_
5	low	low	ADV	RB	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5918
# text = In this paper, we demonstrate that the B2 factor is expressed in the cytosol of monocytes and macrophages as a DNA-binding protein, indicating that it is not associated with an inhibitor (IKB).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	IKB	IKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5919
# text = This factor remained clustered in the cytosol and was translocated to the nuclei only after HIV1 infection.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	clustered	cluster	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5920
# text = The B3 factor is detected in the cytosol only when cells are HIV1-infected.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B3	B3	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5921
# text = The role of HIV1 infection in the expression and the translocation of these factors is discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV1	HIV1	NUM	CD	NumType=Card	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5922
# text = Document 003001522 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001522	003001522	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5923
# text = The intracellular parasite Theileria parva protects infected T cells from apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	_
4	Theileria	Theileria	NOUN	NN	Number=Sing	_	_	_	_
5	parva	parva	NOUN	NN	Number=Sing	_	_	_	_
6	protects	protect	NOUN	NNS	Number=Plur	_	_	_	_
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5924
# text = Parasites have evolved a plethora of strategies to ensure their survival.
1	Parasites	Parasite	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evolved	evolve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	plethora	plethora	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	ensure	ensure	VERB	VB	VerbForm=Inf	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5925
# text = The intracellular parasite Theileria parva secures its propagation and spreads through the infected animal by infecting and transforming T cells, inducing their continuous proliferation and rendering them metastatic.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	_
4	Theileria	Theileria	NOUN	NN	Number=Sing	_	_	_	_
5	parva	parva	NOUN	NN	Number=Sing	_	_	_	_
6	secures	secure	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	propagation	propagation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	spreads	spread	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	infecting	infecte	VERB	VBG	VerbForm=Ger	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	rendering	render	VERB	VBG	VerbForm=Ger	_	_	_	_
28	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
29	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5926
# text = In previous work, we have shown that the parasite induces constitutive activation of the transcription factor NF-kappaB, by inducing the constitutive degradation of its cytoplasmic inhibitors.
1	In	in	ADP	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	_
11	induces	induces	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
30	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5927
# text = The biological significance of NF-kappaB activation in T.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
3	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 5928
# text = parva-infected cells, however, has not yet been defined.
1	parva-infected	parva-infected	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	yet	yet	ADV	RB	_	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5929
# text = Cells that have been transformed by viruses or oncogenes can persist only if they manage to avoid destruction by the apoptotic mechanisms that are activated on transformation and that contribute to maintain cellular homeostasis.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	viruses	virus	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	persist	persist	VERB	VB	VerbForm=Inf	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	if	if	SCONJ	IN	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	manage	manage	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	avoid	avoid	VERB	VB	VerbForm=Inf	_	_	_	_
18	destruction	destruction	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
33	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
34	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5930
# text = We now demonstrate that parasite-induced NF-kappaB activation plays a crucial role in the survival of T. parva-transformed
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_
21	parva	parva	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 5931
# text = T cells by conveying protection against an apoptotic signal that accompanies parasite-mediated transformation.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	conveying	convey	VERB	VBG	VerbForm=Ger	_	_	_	_
5	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	accompanies	accompany	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5932
# text = Consequently, inhibition of NF-kappaB nuclear translocation and the expression of dominant negative mutant forms of components of the NF-kappaB activation pathway, such as IkappaBalpha or p65, prompt rapid apoptosis of T. parva-transformed
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
15	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
16	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
17	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	components	component	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	prompt	prompt	ADJ	JJ	Degree=Pos	_	_	_	_
35	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
36	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_
39	parva	parva	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 5933
# text = T cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5934
# text = Our findings offer important insights into parasite survival strategies and demonstrate that parasite-induced constitutive NF-kappaB activation is an essential step in maintaining the transformed phenotype of the infected cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	offer	offer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	_
8	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
9	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
24	step	step	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	SCONJ	IN	_	_	_	_	_
26	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5935
# text = Document 003001525 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001525	003001525	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5936
# text = TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.
1	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	only	only	ADV	RB	_	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	synergistically	synergistically	ADV	RB	_	_	_	_	_
8	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
9	retinaldehyde	retinaldehyde	NOUN	NN	Number=Sing	_	_	_	_
10	dehydrogenase	dehydrogenase	NOUN	NN	Number=Sing	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
18	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	cofactors	cofactor	NOUN	NNS	Number=Plur	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5937
# text = Previously, we have shown that TAL1 and the LIM-only protein gene (LMO) are regularly coactivated in T-cell acute lymphoblastic leukemia (T-ALL).
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	only	only	ADV	RB	_	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	LMO	LMO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	regularly	regularly	ADV	RB	_	_	_	_	_
20	coactivated	coactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	acute	acute	ADV	RB	_	_	_	_	_
25	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	T	T	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	ALL	All	ADV	RB	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5938
# text = This observation is likely to relate to the findings that TAL1 and LMO are highly synergistic in T-cell tumorigenesis in double-transgenic mice.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	relate	relate	VERB	VB	VerbForm=Inf	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	TAL1	TAL1	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	LMO	LMO	PROPN	NNP	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	highly	highly	ADV	RB	_	_	_	_	_
16	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	tumorigenesis	tumorigenesis	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5939
# text = To understand the molecular mechanisms of functional synergy between TAL1 and LMO in tumorigenesis and transcriptional regulation, we tried to identify downstream target genes regulated by TAL1 and LMO by a subtractive PCR method.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	LMO	Lmo	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	tumorigenesis	tumorigenesis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	tried	try	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
23	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	TAL1	TAL1	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	LMO	LMO	PROPN	NNP	Number=Sing	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	subtractive	subtractive	ADJ	JJ	Degree=Pos	_	_	_	_
34	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
35	method	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5940
# text = One of the isolated genes, that for retinaldehyde dehydrogenase 2 (RALDH2), was regularly expressed in most of the T-ALL cell lines that coexpressed TAL1 and LMO.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	retinaldehyde	retinaldehyde	NOUN	NN	Number=Sing	_	_	_	_
10	dehydrogenase	dehydrogenase	NOUN	NN	Number=Sing	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	RALDH2	Raldh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	regularly	regularly	ADV	RB	_	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	ALL	all	DET	DT	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	coexpressed	coexpress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	TAL1	tAL1	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	LMO	LMO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5941
# text = Exogenously transfected TAL1 and LMO, but not either alone, induced RALDH2 expression in a T-ALL cell line, HPB-ALL, not expressing endogeneous TAL1 or LMO.
1	Exogenously	Exogenously	ADV	RB	_	_	_	_	_
2	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	TAL1	tAL1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	LMO	LMO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	either	either	ADV	RB	_	_	_	_	_
10	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	RALDH2	Raldh2	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	ALL	All	DET	DT	_	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	HPB	HPB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	ALL	All	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	not	not	ADV	RB	_	_	_	_	_
28	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
29	endogeneous	endogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
30	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	LMO	LMO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5942
# text = The RALDH2 transcripts in T-ALL were, however, mostly initiated within the second intron.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	RALDH2	RALDH2	NUM	CD	NumType=Card	_	_	_	_
3	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	ALL	all	ADV	RB	_	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	mostly	mostly	ADV	RB	_	_	_	_	_
12	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5943
# text = Promoter analysis revealed that a GATA site in a cryptic promoter in the second intron was essential and sufficient for the TAL1- and LMO-dependent transcriptional activation, and GATA3 binds to this site.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cryptic	cryptic	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
15	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TAL	Tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	LMO	Lmo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	GATA3	GATA3	NUM	CD	NumType=Card	_	_	_	_
34	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5944
# text = In addition, forced expression of GATA3 potentiated the induction of RALDH2 by TAL1 and LMO, and these three factors formed a complex in vivo.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	forced	force	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GATA3	GATA3	NUM	CD	NumType=Card	_	_	_	_
8	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	RALDH2	RALDH2	NUM	CD	NumType=Card	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	TAL1	TAL1	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	LMO	LMO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	three	three	NUM	CD	NumType=Card	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 5945
# text = Furthermore, a TAL1 mutant not binding to DNA also activated the transcription of RALDH2 in the presence of LMO and GATA3.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	DNA	Dna	PROPN	NNP	Number=Sing	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	RALDH2	RALDH2	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	LMO	LMO	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5946
# text = Collectively, we have identified the RALDH2 gene as a first example of direct transcriptional target genes regulated by TAL1 and LMO in T-ALL.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	RALDH2	Raldh2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
12	example	example	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	target	target	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	TAL1	TAL1	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	LMO	LMO	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5947
# text = In this case, TAL1 and LMO act as cofactors for GATA3 to activate the transcription of RALDH2.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	case	case	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	LMO	Lmo	NOUN	NN	Number=Sing	_	_	_	_
8	act	act	NOUN	NN	Number=Sing	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	cofactors	cofactor	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	RALDH2	Raldh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5948
# text = Document 003001534 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001534	003001534	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5949
# text = Posttranscriptional regulation of macrophage tissue factor expression by antioxidants.
1	Posttranscriptional	Posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5950
# text = Tissue factor (TF) expression by cells of monocyte/macrophage lineage represents an important mechanism underlying the initiation of fibrin deposition at sites of extravascular inflammation.
1	Tissue	Tissue	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
13	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
14	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	fibrin	fibrin	NOUN	NN	Number=Sing	_	_	_	_
23	deposition	deposition	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	extravascular	extravascular	ADJ	JJ	Degree=Pos	_	_	_	_
28	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5951
# text = Recent evidence suggests a role for oxidant stress in the signalling pathway of various cell types by virtue of its ability to induce DNA binding of various transcription factors, including nuclear factor kappa B and AP-1.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
8	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	signalling	signall	NOUN	NN	Number=Sing	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	types	type	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	virtue	virtue	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5952
# text = The effect of antioxidant treatment on lipopolysaccharide (LPS)-induced TF expression was examined in murine peritoneal macrophages and human monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	murine	murine	PRON	PRP	_	_	_	_	_
19	peritoneal	peritoneal	ADJ	JJ	Degree=Pos	_	_	_	_
20	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5953
# text = Both pyrrolidine dithiocarbamate, an oxidant scavenger, and N-acetyl-cysteine, a precursor of the endogenous antioxidant glutathione, inhibited stimulation of macrophage procoagulant activity by LPS.
1	Both	both	DET	DT	_	_	_	_	_
2	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
3	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
7	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
20	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
21	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
27	procoagulant	procoagulant	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5954
# text = Northern blot analysis showed that neither of these agents reduced LPS-stimulated TF mRNA accumulation, thereby suggesting a posttranscriptional mechanism for the effect.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	neither	neither	DET	DT	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
10	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
15	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
16	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	thereby	thereby	ADV	RB	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5955
# text = Immunofluorescence studies of human monocytes using polyclonal anti-TF antibody showed that N-acetyl-cysteine treatment prevented the characteristic plasmalemmal localization of TF antigen that occurs in response to LPS.
1	Immunofluorescence	Immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
9	-TF	-tf	PROPN	NNP	Number=Sing	_	_	_	_
10	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
21	plasmalemmal	plasmalemmal	NOUN	NN	Number=Sing	_	_	_	_
22	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
25	antigen	antigen	VERB	VB	VerbForm=Inf	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5956
# text = Western blot analysis showed that N-acetyl-cysteine reduced the accumulation of the 47-kD mature glycoprotein in LPS-treated cells, a finding consistent with the results of the immunofluorescence studies.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
10	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
18	mature	mature	NOUN	NN	Number=Sing	_	_	_	_
19	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
28	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	results	result	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
35	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5957
# text = Furthermore, these conditions did not result in an accumulation of the less mature forms of TF.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	less	less	ADV	RBS	_	_	_	_	_
14	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
15	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5958
# text = When considered together, these data suggest that antioxidants exert their effects by impairing translation and/or by causing degradation of newly translated protein.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	data	data	NOUN	NN	Number=Sing	_	_	_	_
7	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
10	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	impairing	impair	VERB	VBG	VerbForm=Ger	_	_	_	_
15	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	or	or	CCONJ	CC	_	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
21	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	newly	newly	ADV	RB	_	_	_	_	_
24	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5959
# text = The effect of antioxidants on tumor necrosis factor appeared to be species specific, with no effect on LPS-induced tumor necrosis factor in murine cells, but with inhibition in human monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	species	species	NOUN	NNS	Number=Plur	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	no	no	DET	DT	_	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
23	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5960
# text = The posttranscriptional effect of antioxidants on TF expression data suggests a novel mechanism whereby these agents might modulate monocyte/macrophage activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	data	data	NOUN	NN	Number=Sing	_	_	_	_
10	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	whereby	whereby	SCONJ	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
17	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
18	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
19	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5961
# text = Document 003001535 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001535	003001535	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5962
# text = Natural variants of the HIV-1 long terminal repeat: analysis of promoters with duplicated DNA regulatory motifs.
1	Natural	Natural	ADJ	JJ	Degree=Pos	_	_	_	_
2	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
9	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
10	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	duplicated	duplicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5963
# text = Sequence variation in the long terminal repeat (LTR) region of HIV-1 was analyzed in viral isolates of 17 infected individuals.
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
6	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
7	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
20	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	17	17	NUM	CD	NumType=Card	_	_	_	_
23	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5964
# text = Two classes of LTR size variants were found.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LTR	Ltr	ADJ	JJ	Degree=Pos	_	_	_	_
5	size	size	NOUN	NN	Number=Sing	_	_	_	_
6	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5965
# text = One HIV-1 variant was detected containing an additional binding site for the transcription factor Sp1.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5966
# text = Another LTR size variation was observed in four patients in a region just upstream of the NF-kappa B enhancer.
1	Another	another	DET	DT	_	_	_	_	_
2	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
3	size	size	NOUN	NN	Number=Sing	_	_	_	_
4	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	four	four	NUM	CD	NumType=Card	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	just	just	ADV	RB	_	_	_	_	_
14	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5967
# text = This variation was the result of a duplication of a short DNA sequence (CTG-motif).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	result	result	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	duplication	duplication	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CTG-motif	CTG-motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5968
# text = Cell culture experiments demonstrated that the natural variant with four Sp1 sites had a slightly higher promoter activity and viral replication rate than the isogenic control LTR with three Sp1 sites.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
8	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	four	four	NUM	CD	NumType=Card	_	_	_	_
11	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	slightly	slightly	ADV	RB	_	_	_	_	_
16	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	isogenic	isogenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	control	control	NOUN	NN	Number=Sing	_	_	_	_
27	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	three	three	NUM	CD	NumType=Card	_	_	_	_
30	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
31	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5969
# text = No positive effect of the duplicated CTG-motif could be detected.
1	No	no	DET	DT	_	_	_	_	_
2	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	duplicated	duplicate	ADJ	JJ	Degree=Pos	_	_	_	_
7	CTG-	Ctg-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5970
# text = In order to measure small differences in virus production more accurately, equal amounts of a size variant and the wild-type plasmid were cotransfected into T-cells.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	measure	measure	VERB	VB	VerbForm=Inf	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	accurately	accurately	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	_
14	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	size	size	NOUN	NN	Number=Sing	_	_	_	_
18	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	into	into	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5971
# text = The virus with four Sp1 sites did outgrow the three Sp1 virus in 35 days of culture and CTG-monomer virus outcompeted the CTG-dimer virus in 42 days.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	four	four	NUM	CD	NumType=Card	_	_	_	_
5	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	outgrow	outgrow	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	35	35	NUM	CD	NumType=Card	_	_	_	_
15	days	day	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CTG-monomer	CTG-monomer	NOUN	NN	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	outcompeted	outcompete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CTG-	Ctg-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	42	42	NUM	CD	NumType=Card	_	_	_	_
28	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5972
# text = Based on these results we estimate a 5-10% difference in virus production of the LTR variants when compared to that of wild-type.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	estimate	estimate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
19	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5973
# text = Document 003001537 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001537	003001537	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5974
# text = Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	Nef	Nef	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	regulates	regulate	VERB	NNS	Number=Plur	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5975
# text = Human immunodeficiency virus type 1 (HIV-1) negative factor (Nef) has been shown to down-regulate the transcription factors NF-kappa B and AP-1 in vitro.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5976
# text = To define the mechanism of action of the Nef protein, the signal transduction pathways which may be affected in T cells by constitutive expression of the nef gene were examined.
1	To	to	PART	TO	_	_	_	_	_
2	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	action	action	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5977
# text = Stimulation of T cells with tumor necrosis factor, interleukin-1, or lipopolysaccharide resulted in the recruitment of transcriptional factors to a similar level whether or not the cells expressed the nef gene.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
16	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	whether	whether	SCONJ	IN	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nef	nef	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5978
# text = On the other hand, stimulation of T cells by mitogens or antibodies to the T-cell receptor (TCR)-CD3 complex resulted in the down-regulation of transcriptional factors NF-kappa B and AP-1 in cells expressing the nef gene compared with cells not expressing the nef gene.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
47	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
48	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	not	not	ADV	RB	_	_	_	_	_
52	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
55	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5979
# text = Because the Nef protein does not affect the surface expression of the CD3-TCR complex, we conclude that the Nef protein down-regulates the transcriptional factors NF-kappa B and AP-1 in T cells in vitro through an effect on the TCR-dependent signal transduction pathway.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	T	t	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
43	through	through	ADP	IN	_	_	_	_	_
44	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
46	on	on	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
51	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
52	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
53	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5980
# text = Document 003001539 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001539	003001539	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5981
# text = Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
4	AMP	AMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5982
# text = Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	highly	highly	ADV	RB	_	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
10	AMP	Amp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
42	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
47	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
48	long	long	ADV	RB	Degree=Pos	_	_	_	_
49	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
50	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5983
# text = This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C-	C-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	cyclic	cyclic	PROPN	NNP	Number=Sing	_	_	_	_
16	AMP	Amp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
27	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	number	number	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5984
# text = Document 003001540 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001540	003001540	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5985
# text = Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	interferon	interferon	ADP	IN	_	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5986
# text = Interleukin-10 (IL-10) helps maintain polarized T-helper cells in a T-helper lymphocyte 2 (Th2) phenotype.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	helps	help	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
11	polarized	polarize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
19	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Th2	Th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5987
# text = Part of this process involves the prevention of the development of Th1 cells, which are a primary source of interferon gamma (IFNgamma), a potent activator of monocytes and an inhibitor of Th2 proliferation.
1	Part	part	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	process	process	NOUN	NN	Number=Sing	_	_	_	_
5	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	source	source	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
29	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
37	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5988
# text = Because monocytes and macrophages are important mediators of Th1-type responses, such as delayed-type hypersensitivity, we sought to determine if IL-10 could directly mediate inhibition of IFNgamma- and IFNalpha-induced gene expression in these cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Th1	Th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	hypersensitivity	hypersensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
25	if	if	SCONJ	IN	_	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
30	directly	directly	ADV	RB	_	_	_	_	_
31	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
32	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	IFNalpha	IFNalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5989
# text = Highly purified monocytes were incubated with IL-10 for 60 to 90 minutes before the addition of IFNgamma or IFNalpha.
1	Highly	highly	ADV	RB	_	_	_	_	_
2	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	60	60	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	90	90	NUM	CD	NumType=Card	_	_	_	_
14	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
15	before	before	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	IFNalpha	IFNalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5990
# text = IL-10 preincubation resulted in the inhibition of gene expression for several IFN-induced genes, such as IP-10, ISG54, and intercellular adhesion molecule-1.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	IP	IP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	ISG54	ISG54	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
30	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5991
# text = The reduction in gene expression resulted from the ability of IL-10 to suppress IFN-induced assembly of signal transducer and activator of transcription (STAT) factors to specific promoter motifs on IFNalpha- and IFNgamma-inducible genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	suppress	suppress	PROPN	NNP	Number=Sing	_	_	_	_
16	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
22	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	IFNalpha	IFNalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
42	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5992
# text = This was accomplished by preventing the IFN-induced tyrosine phosphorylation of STAT1, a component of both IFNalpha- and IFNgamma-induced DNA binding complexes.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	accomplished	accomplish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	SCONJ	IN	_	_	_	_	_
5	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	component	component	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	IFNalpha	IFNalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5993
# text = Therefore, IL-10 can directly inhibit STAT-dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	directly	directly	ADV	RB	_	_	_	_	_
8	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
9	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	IFNalpha	IFNalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	by	by	SCONJ	IN	_	_	_	_	_
25	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
28	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5994
# text = This may occur through the ability of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 (SOCS3).
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
4	through	through	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
22	3	3	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	SOCS3	SOCS3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 5995
# text = Document 003001542 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001542	003001542	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 5996
# text = Okadaic acid is a potent inducer of AP-1, NF-kappa B, and tumor necrosis factor-alpha in human B lymphocytes.
1	Okadaic	Okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
6	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
19	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 5997
# text = Treatment of human B lymphocytes with an optimal concentration of okadaic acid, an inhibitor of phosphatases 1 and 2A, resulted in the induction of the transcription factor, AP-1 and a marked increase in NF-kappa B levels.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	2A	2a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	B	b	NOUN	NN	Number=Sing	_	_	_	_
43	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5998
# text = In contrast, no effect on the levels of the octamer binding proteins, Oct-1 or Oct-2, were found.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5999
# text = Since both AP-1 and NF-kappa B have been reported to be important in the induction of the tumor necrosis factor-alpha (TNF-alpha) gene we examined the effects of okadaic acid on TNF-alpha mRNA levels.
1	Since	since	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
23	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
34	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
39	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
44	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6000
# text = Treatment with okadaic acid resulted in a striking increase in TNF-alpha mRNA transcripts within 1 h of stimulation and large amounts of TNF-alpha were released into the culture media.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
4	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	striking	striking	NOUN	NN	Number=Sing	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
23	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	released	release	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	into	into	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
33	media	media	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6001
# text = Although okadaic acid provides a potent inductive signal for AP-1 and NF-kappa B it did not induce either B cell proliferation or immunoglobulin secretion.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
3	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
4	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	inductive	inductive	ADJ	JJ	Degree=Pos	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	either	either	CCONJ	CC	_	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
28	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6002
# text = Document 003001543 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001543	003001543	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6003
# text = Long-term inositol phosphate release, but not tyrosine kinase activity, correlates with IL-2 secretion and NF-AT induction in anti-CD3-activated peripheral human T lymphocytes.
1	Long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	term	term	NOUN	NN	Number=Sing	_	_	_	_
4	inositol	inositol	NOUN	NN	Number=Sing	_	_	_	_
5	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
6	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	tyrosine	tyrosine	VERB	VB	VerbForm=Inf	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	AT	at	NOUN	NN	Number=Sing	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-activated	-activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6004
# text = The cascade of events within the first few minutes of T cell stimulation has been well characterized.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
9	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6005
# text = Although many second messengers have been shown to be necessary and sufficient for T cell activation in a number of model systems, the rate-limiting step in peripheral T cells has not been demonstrated.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
4	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	T	t	NUM	CD	NumType=Card	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	number	number	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	model	model	NOUN	NN	Number=Sing	_	_	_	_
22	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	limiting	limiting	NOUN	NN	Number=Sing	_	_	_	_
28	step	step	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6006
# text = To model effective versus ineffective CD3-mediated stimulation in peripheral T cells, we used two anti-CD3 mAbs that differ in their ability to stimulate purified T cells: OKT3, which causes early second messenger generation but is unable to activate T cells without a second signal, and 64.1, which stimulates T cell proliferation on its own.
1	To	to	PART	TO	_	_	_	_	_
2	model	model	VERB	VB	VerbForm=Inf	_	_	_	_
3	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
4	versus	versus	CCONJ	CC	_	_	_	_	_
5	ineffective	ineffective	ADJ	JJ	Degree=Pos	_	_	_	_
6	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
19	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	:	:	PUNCT	:	_	_	_	_	_
31	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	causes	caus	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
36	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
37	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
38	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	without	without	ADP	IN	_	_	_	_	_
47	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
49	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	64.1	64.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	which	which	PRON	WDT	PronType=Rel	_	_	_	_
55	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
56	T	t	NUM	CD	NumType=Card	_	_	_	_
57	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
58	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
59	on	on	ADP	IN	_	_	_	_	_
60	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
61	own	own	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6007
# text = We found that tyrosine kinase activity was similar for both mAbs over a period of hours.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	mAbs	mAbs	NOUN	NNS	Number=Plur	_	_	_	_
12	over	over	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	period	period	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6008
# text = However, the inositol phosphate response was stronger for 64.1 than for OKT3.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inositol	inositol	ADJ	JJ	Degree=Pos	_	_	_	_
5	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	64.1	64.1	NUM	CD	NumType=Card	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6009
# text = To tie these events to gene activation, we measured NF-kappa B and NF-AT activity in the nucleus after anti-CD3 stimulation.
1	To	to	PART	TO	_	_	_	_	_
2	tie	tie	VERB	VB	VerbForm=Inf	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
23	after	after	ADP	IN	_	_	_	_	_
24	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6010
# text = Both stimuli induced the appearance of the NF-kappa B components (c-Rel, p65 (RelA), and p50 (NF-kappa B1)) and NF-kappa B DNA binding activity in the nucleus.
1	Both	both	DET	DT	_	_	_	_	_
2	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
3	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	components	component	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	p65	p65	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	p50	p50	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B1	B1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
38	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
39	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6011
# text = However, only 64.1 induced NF-AT in the nucleus, correlating with its ability to activate T cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	64.1	64.1	NUM	CD	NumType=Card	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	At	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	correlating	correlat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6012
# text = Thus, NF-AT induction and IL-2 secretion were correlated with the levels of inositol phosphate release but not with gross levels of tyrosine kinase activity induced late following the response.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	AT	AT	ADJ	JJ	Degree=Pos	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	inositol	inositol	ADJ	JJ	Degree=Pos	_	_	_	_
19	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
20	release	release	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	gross	gross	ADJ	JJ	Degree=Pos	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	late	late	ADV	RB	Degree=Pos	_	_	_	_
32	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6013
# text = On the other hand, NF-kappa B induction and IL-2 receptor expression occurred even with the smaller second messenger response generated by OKT3.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	even	even	ADV	RB	_	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	smaller	smaller	ADJ	JJR	Degree=Cmp	_	_	_	_
22	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
23	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6014
# text = Document 003001555 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001555	003001555	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6015
# text = Differentiation of T-helper lymphocytes: selective regulation by members of the STAT family of transcription factors.
1	Differentiation	Differentiation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6016
# text = Interleukin-4 (IL-4) and interleukin-12 (IL-12) control the differentiation of T-helper cells.
1	Interleukin	Interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-12	-12	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6017
# text = Here we summarize studies which investigate the mechanism by which these cytokines selectively reprogramme gene expression in T-lymphocytes.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	summarize	summarize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
13	selectively	selectively	ADV	RB	_	_	_	_	_
14	reprogramme	reprogramme	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6018
# text = Cytokine stimulation leads to the phosphorylation of specific tyrosine residues within the intracellular domain of the corresponding cytokine receptor.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	corresponding	correspond	NOUN	NN	Number=Sing	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6019
# text = These phosphotyrosines serve as docking sites for latent, cytoplasmic transcription factors known as signal transducers and activators of transcription (Stat) proteins.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	phosphotyrosines	phosphotyrosine	NOUN	NNS	Number=Plur	_	_	_	_
3	serve	serve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	as	as	SCONJ	IN	_	_	_	_	_
5	docking	docke	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
16	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6020
# text = Receptor/Stat interaction is mediated by the src homology 2 (SH2) domain of the corresponding
1	Receptor	Receptor	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	src	src	NOUN	NN	Number=Sing	_	_	_	_
10	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	SH2	SH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6021
# text = Stat protein.
1	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6022
# text = Although Stat binding to the intracellular domain of the cytokine receptor strongly depends on the phosphotyrosine residue, the recruitment of a specific
1	Although	although	SCONJ	IN	_	_	_	_	_
2	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	phosphotyrosine	phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	residue	residue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 6023
# text = Stat protein is dictated by amino acid residues C-terminal to the phosphotyrosine.
1	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	dictated	dictate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	amino	amino	DET	DT	_	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
8	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
9	C-	C-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	phosphotyrosine	phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6024
# text = Specific docking sites within individual cytokine receptors have been identified for almost all Stat proteins.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	docking	docking	NOUN	NN	Number=Sing	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	within	within	ADP	IN	_	_	_	_	_
5	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	almost	almost	ADV	RB	_	_	_	_	_
13	all	all	DET	DT	_	_	_	_	_
14	Stat	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6025
# text = The direct coupling between cytokine receptor and transcription factor helps to explain how different cytokines elicit distinct patterns of gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	coupling	coupling	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	helps	help	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
13	how	how	ADV	WRB	PronType=Int	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
16	elicit	elicit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
18	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6026
# text = Document 003001556 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001556	003001556	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6027
# text = Function of NF-kappa
1	Function	function	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6028
# text = B/Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B/Rel subunits.
1	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	class	class	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	invariant	invariant	ADJ	JJ	Degree=Pos	_	_	_	_
14	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
31	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6029
# text = The promoter of the human major histocompatibility complex class II-associated invariant-chain gene
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	invariant	invariant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6030
# text = (Ii) contains two NF-kappa B/Rel binding sites located at -109 to -118 (Ii kappa B-1) and -163 to -172 (Ii kappa B-2) from the transcription start site.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ii	ii	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	109	109	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	118	118	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Ii	ii	PROPN	NNP	Number=Sing	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	X	LS	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	163	163	NUM	CD	NumType=Card	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	172	172	NUM	CD	NumType=Card	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	Ii	ii	PROPN	NNP	Number=Sing	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
44	start	start	NOUN	NN	Number=Sing	_	_	_	_
45	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6031
# text = We report here that the differential function of each of these NF-kappa B/Rel sites in several distinct cell types depends on cell-specific binding of NF-kappa B/Rel transcription factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	each	each	DET	DT	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
21	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	types	type	NOUN	NNS	Number=Plur	_	_	_	_
24	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6032
# text = Ii kappa B-1 is a positive regulatory element in B-cell lines and in the Ii-expressing T-cell line, H9, but acts as a negative regulatory element in myelomonocytic and glia cell lines.
1	Ii	ii	PROPN	NNP	Number=Sing	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Ii	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	H9	H9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
33	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
34	element	element	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	glia	glia	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6033
# text = In vivo protein-DNA contacts are detectable at
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	contacts	contact	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_

# sent_id = 6034
# text = Ii kappa B-1 in cell lines in which this site is functional as either a positive or negative regulator.
1	Ii	ii	PROPN	NNP	Number=Sing	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6035
# text = Electrophoretic mobility supershift assays determine that members of the NF-kappa B/Rel family of transcription factors can bind to this site in vitro and that DNA-binding complexes that contain p50, p52, p65, and cRel correlate with positive regulation whereas the presence of p50 correlates with negative regulation.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	supershift	supershift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	determine	determine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	members	member	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	cRel	cRel	NOUN	NN	Number=Sing	_	_	_	_
43	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
46	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
47	whereas	whereas	SCONJ	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	p50	p50	NUM	CD	NumType=Card	_	_	_	_
52	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
55	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6036
# text = Ii kappa B-2 is a site of positive regulation in B-cell lines and a site of negative regulation in H9 T cells, myelomonocytic, and glial cell lines.
1	Ii	ii	PROPN	NNP	Number=Sing	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	H9	H9	PROPN	NNP	Number=Sing	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6037
# text = In vivo occupancy of this site is observed only in the H9 T-cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	H9	h9	NOUN	NN	Number=Sing	_	_	_	_
13	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6038
# text = Again, in vitro supershift studies indicate that the presence of p50, p52, p65, and cRel correlates with positive function whereas the presence of only p50 and p52 correlates with negative function.
1	Again	again	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cRel	cRel	NOUN	NN	Number=Sing	_	_	_	_
20	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	function	function	NOUN	NN	Number=Sing	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	p50	p50	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	p52	p52	NUM	CD	NumType=Card	_	_	_	_
32	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
35	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6039
# text = This differential binding of specific NF-kappa B/Rel subunits is likely to mediate the disparate functions of these two NF-kappa B/Rel binding sites.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	differential	differential	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	disparate	disparate	ADJ	JJ	Degree=Pos	_	_	_	_
19	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6040
# text = Document 003001557 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001557	003001557	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6041
# text = Induction of relA(p65) and I kappa B alpha subunit expression during differentiation of human peripheral blood monocytes to macrophages.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	relA	relA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	p65	p65	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
10	B	b	X	LS	_	_	_	_	_
11	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6042
# text = We evaluated the expression and DNA binding activity of nuclear factor (NF)-kappa B subunits in human peripheral blood monocytes and in monocyte-derived macrophages (MDMs).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	MDMs	Mdms	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6043
# text = Constitutive DNA binding activity consisting of p50 homodimers was detected in nuclear extracts from both cell types.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	consisting	consisting	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p50	p50	NUM	CD	NumType=Card	_	_	_	_
8	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6044
# text = An additional complex composed of p50/RelA(p65) heterodimers appeared only in nuclear extracts from 7-day MDMs.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
12	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	day	day	NOUN	NN	Number=Sing	_	_	_	_
21	MDMs	MDM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6045
# text = Immunoblot analysis showed that the p50 subunit was constitutively expressed in monocytes and MDMs.
1	Immunoblot	Immunoblot	PROPN	NNP	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	constitutively	constitutively	ADV	RB	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	MDMs	MDM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6046
# text = In contrast, the RelA(p65) subunit was barely detectable in monocytes, but its level increased markedly in MDMs.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	barely	barely	ADV	RB	_	_	_	_	_
12	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
18	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	markedly	markedly	ADV	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	MDMs	Mdms	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6047
# text = Analysis of RelA(p65) mRNA revealed that the stability of RelA(p65) mRNA was significantly higher in MDMs, compared with monocytes.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	p65	p65	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	MDMs	Mdms	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6048
# text = In MDMs, an upregulation of I kappa B alpha synthesis as well as the appearance of a novel M(r) 40,000 form of I kappa B alpha were also observed.
1	In	in	ADP	IN	_	_	_	_	_
2	MDMs	Mdms	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
9	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
20	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	r	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	40,000	40,000	NUM	CD	NumType=Card	_	_	_	_
25	form	form	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	B	PROPN	NNP	Number=Sing	_	_	_	_
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6049
# text = These results suggest that macrophage differentiation results in the expression of active p50/RelA(p65) heterodimers with the capacity to activate target gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
13	p50/	p50/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6050
# text = The parallel induction of I kappa B alpha synthesis may allow for the continuous presence of a cytoplasmic reservoir of p50/RelA(p65) complexes that are readily available for inducer-mediated stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
7	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
19	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	p50/	p50/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
22	RelA	Rela	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	readily	readily	ADV	RB	_	_	_	_	_
30	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	inducer	inducer	ADV	RB	_	_	_	_	SpaceAfter=No
33	-mediated	-mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6051
# text = Document 003001558 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001558	003001558	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6052
# text = CholecystokininB receptor from human Jurkat lymphoblastic T cells is involved in activator protein-1-responsive gene activation.
1	CholecystokininB	Cholecystokininb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6053
# text = The aim of this study was to analyze the role of cholecystokinin (CCK(B)) receptor in human lymphoblastic Jurkat T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cholecystokinin	cholecystokinin	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CCK	Cck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6054
# text = We investigated the trophic effect resulting from activation of such a receptor by using the reporter gene strategy.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	trophic	trophic	ADJ	JJ	Degree=Pos	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	such	such	DET	PDT	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6055
# text = For this purpose, we transiently transfected Jurkat T cells with the reporter plasmid p[(TRE)3-tk-Luc] and found that CCK-8 was able to dose-dependently induce luciferase expression related to activator protein-1 (AP-1) activation with a maximal response identical to that obtained with compounds known to activate AP-1 complex (quantitatively, the same level of induction was obtained with 1 nM 12-O-tetradecanoylphorbol-13-acetate, 100 microM diacylglycerol, or 4 nM epidermal growth factor).
1	For	for	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	transiently	transiently	ADV	RB	_	_	_	_	_
7	transfected	transfect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
15	p[	p[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	tk	tk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Luc	Luc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	]	]	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	CCK	CCK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	8	8	PROPN	NNP	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	dose	dose	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependently	dependently	ADV	RB	_	_	_	_	_
37	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
38	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	activator	activator	VERB	VB	VerbForm=Inf	_	_	_	_
43	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
52	with	with	ADP	IN	_	_	_	_	_
53	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
55	response	response	NOUN	NN	Number=Sing	_	_	_	_
56	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
57	to	to	ADP	IN	_	_	_	_	_
58	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
59	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
60	with	with	ADP	IN	_	_	_	_	_
61	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
62	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
63	to	to	PART	TO	_	_	_	_	_
64	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
65	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	1	1	NUM	CD	NumType=Card	_	_	_	_
68	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
69	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
70	quantitatively	quantitatively	ADV	RB	_	_	_	_	SpaceAfter=No
71	,	,	PUNCT	,	_	_	_	_	_
72	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
73	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
74	level	level	NOUN	NN	Number=Sing	_	_	_	_
75	of	of	ADP	IN	_	_	_	_	_
76	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
77	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
78	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
79	with	with	ADP	IN	_	_	_	_	_
80	1	1	NUM	CD	NumType=Card	_	_	_	_
81	nM	nm	NUM	CD	NumType=Card	_	_	_	_
82	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
84	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	100	100	NUM	CD	NumType=Card	_	_	_	_
87	microM	microm	NUM	CD	NumType=Card	_	_	_	_
88	diacylglycerol	diacylglycerol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
89	,	,	PUNCT	,	_	_	_	_	_
90	or	or	CCONJ	CC	_	_	_	_	_
91	4	4	NUM	CD	NumType=Card	_	_	_	_
92	nM	nm	ADJ	JJ	Degree=Pos	_	_	_	_
93	epidermal	epidermal	ADJ	JJ	Degree=Pos	_	_	_	_
94	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
95	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
96	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
97	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6056
# text = The involvement of the CCK(B) receptor in such a stimulation was demonstrated by the inhibiting effect of the selective CCK(B) receptor antagonist PD-135,158.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CCK	CCK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	B	b	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	such	such	DET	PDT	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
23	CCK	CCK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	B	b	X	LS	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
29	PD	P	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-135,158	-135,158	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6057
# text = This effect was confirmed in COS-7 cells transfected with the cDNA of CCK(B) receptor cloned from Jurkat T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	7	7	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CCK	CCK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
23	T	T	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6058
# text = To better understand the AP-1-dependent luciferase expression in Jurkat T cells, we tested two specific inhibitors of serine/threonine phosphatases-1 and -2A: okadaic acid and calyculin A.
1	To	to	ADV	RB	_	_	_	_	_
2	better	better	ADV	RBR	Degree=Cmp	_	_	_	_
3	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
26	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	:	:	PUNCT	:	_	_	_	_	_
33	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
34	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	calyculin	calyculin	NOUN	NN	Number=Sing	_	_	_	_
37	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6059
# text = These compounds strongly increased the phorbol-12-myristate-13-acetate response, whereas we have not observed a contribution of phosphatase inhibitors on a CCK-8-induced luciferase activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-12-myristate	-12-myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-acetate	-acetate	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
21	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	CCK	CCK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6060
# text = To confirm that CCK(B) receptors are involved in AP-1 response, we investigated the CCK-8 effect on interleukin-2 expression, a natural endogenous gene regulated by several factors, including AP-1.
1	To	to	PART	TO	_	_	_	_	_
2	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	CCK	CCK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CCK	CCK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	8	8	NUM	CD	NumType=Card	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
32	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
40	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6061
# text = In Jurkat T cells activated by phorbol-12-myristate-13-acetate and phytohemagglutinin, CCK-8 induced IL-2 expression.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-12-myristate	-12-myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	CCK	CCK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	8	8	PROPN	NNP	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6062
# text = This induction was abolished by PD-135,158.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	PD	PD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	135,158	135,158	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6063
# text = Our results indicate that CCK-8 exerts a trophic effect in Jurkat T cells through stimulation of CCK(B) receptors by modulation of expression of AP-1-regulated genes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CCK	CCK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	8	8	NUM	CD	NumType=Card	_	_	_	_
8	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	trophic	trophic	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CCK	CCK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6064
# text = Document 003001565 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001565	003001565	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6065
# text = Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide.
1	Phosphatidylinositides	Phosphatidylinositides	NOUN	NNS	Number=Plur	_	_	_	_
2	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
5	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
6	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	14	14	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
11	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6066
# text = Although bacterial lipopolysaccharides (LPS) and several other microbial agonists can bind to mCD14 (membrane CD14), a cell-surface receptor found principally on monocytes and neutrophils, host-derived mCD14 ligands are poorly defined.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
3	lipopolysaccharides	lipopolysaccharide	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
10	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
11	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	principally	principally	ADV	RB	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	mCD	mcd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	14	14	NUM	CD	NumType=Card	_	_	_	_
39	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
40	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	poorly	poorly	ADV	RB	_	_	_	_	_
42	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6067
# text = We report here that phosphatidylinositol (PtdIns), phosphatidylinositol-4-phosphate, and other phosphatidylinositides can bind to mCD14.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	phosphatidylinositides	phosphatidylinositide	NOUN	NNS	Number=Plur	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	mCD14	mCD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6068
# text = Phosphatidylserine (PS), another anionic glycerophospholipid, binds to mCD14 with lower apparent affinity than does PtdIns.
1	Phosphatidylserine	Phosphatidylserine	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	PS	ps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	another	another	DET	DT	_	_	_	_	_
7	anionic	anionic	ADJ	JJ	Degree=Pos	_	_	_	_
8	glycerophospholipid	glycerophospholipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
15	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
16	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	does	do	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6069
# text = LPS-binding protein, a lipid transfer protein found in serum, facilitates both PS- and PtdIns-mCD14 binding.
1	LPS	Lp	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
8	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	facilitates	facilitate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	PS	ps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	PtdIns-	PtdIns-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	mCD14	mCD14	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6070
# text = PtdIns binding to mCD14 can be blocked by anti-CD14 monoclonal antibodies that inhibit LPS-mCD14 binding, and PtdIns can inhibit both LPS-mCD14 binding and LPS-induced responses in monocytes.
1	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	mCD14	mCD14	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	anti-CD	anti-cd	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	14	14	NUM	CD	NumType=Card	_	_	_	_
11	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mCD14	mcd14	NOUN	NN	Number=Sing	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
24	both	both	CCONJ	CC	_	_	_	_	_
25	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mCD14	mcd14	PROPN	NNP	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6071
# text = Serum-equilibrated PtdIns also binds to mCD14-expressing cells, raising the possibility that endogenous PtdIns may modulate cellular responses to LPS and other mCD14 ligands in vivo.
1	Serum-	Serum-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	equilibrated	equilibrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PtdIns	PtdIns	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-expressing	-expressing	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	raising	raise	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
19	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	mCD	mcd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	14	14	NUM	CD	NumType=Card	_	_	_	_
27	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6072
# text = Document 003001581 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001581	003001581	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6073
# text = Transcriptional regulation of the pyruvate kinase erythroid-specific promoter.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	pyruvate	pyruvate	ADJ	JJ	Degree=Pos	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6074
# text = Mammal pyruvate kinases are encoded by two genes.
1	Mammal	Mammal	ADJ	JJ	Degree=Pos	_	_	_	_
2	pyruvate	pyruvate	NOUN	NN	Number=Sing	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6075
# text = The L gene produces the erythroid (R-PK) or the hepatic (L-PK) isozymes by the alternative use of two promoters.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	produces	produce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	PK	PK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	hepatic	hepatic	ADJ	JJ	Degree=Pos	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	L	L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	PK	PK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	isozymes	isozyme	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
24	use	use	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	two	two	NUM	CD	NumType=Card	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6076
# text = We report the characterization of the cis- and trans-acting elements involved in the tissue-specific activity of the L gene erythroid promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	L	L	PROPN	NNP	Number=Sing	_	_	_	_
24	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
25	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6077
# text = A R-PK DNA fragment extending from -870 to +54 relative to the cap site confers erythroid specificity to a reporter gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	R	R	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	PK	PK	NOUN	NN	Number=Sing	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
7	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	870	870	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
13	54	54	NUM	CD	NumType=Card	_	_	_	_
14	relative	relative	ADV	RB	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6078
# text = Within this region, we define a minimal promoter (-62 to +54) that displays erythroid-specific activity and contains two DNA binding sites.
1	Within	within	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
11	62	62	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
14	54	54	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6079
# text = One, located at -50, binds members of the CCACC/Sp1 family and the other, located at -20, binds the erythroid factor GATA-1.
1	One	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CCACC	CCACC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6080
# text = Although the -20 GATA binding site (AGATAA) is also a potential TFIID binding site, it does not bind TFIID.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	20	20	NUM	CD	NumType=Card	_	_	_	_
5	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	AGATAA	AGATAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
15	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
23	TFIID	tFIId	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6081
# text = Furthermore, the substitution of this GATA binding site by a canonical TFIID binding site suppresses the promoter activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	canonical	canonical	ADJ	JJ	Degree=Pos	_	_	_	_
13	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6082
# text = Mutations and deletions of both sites indicate that only the association of CCACC/Sp1 and GATA binding sites can drive efficient and tissue-specific expression of this R-PK minimal promoter.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	association	association	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CCACC	CCACC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	drive	drive	VERB	VB	VerbForm=Inf	_	_	_	_
22	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	PK	PK	PROPN	NNP	Number=Sing	_	_	_	_
33	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6083
# text = Finally, by co-transfection experiments, we study the elements involved in the hGATA-1 transactivation of the R-PK promoter in HeLa cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	study	study	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
11	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	PK	PK	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6084
# text = Document 003001585 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001585	003001585	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6085
# text = The peri-kappa B site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6086
# text = Human immunodeficiency virus type 2 (HIV-2), like HIV-1, causes AIDS and is associated with AIDS cases primarily in West Africa.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	like	like	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	AIDS	aid	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
24	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
25	primarily	primarily	ADV	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	West	West	PROPN	NNP	Number=Sing	_	_	_	_
28	Africa	Africa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6087
# text = HIV-1 and HIV-2 display significant differences in nucleic acid sequence and in the natural history of clinical disease.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	display	display	NOUN	NN	Number=Sing	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	nucleic	nucleic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
19	history	history	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6088
# text = Consistent with these differences, we have previously demonstrated that the enhancer/promoter region of HIV-2 functions quite differently from that of HIV-1.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	differences	difference	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	previously	previously	ADV	RB	_	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
21	quite	quite	ADV	RB	_	_	_	_	_
22	differently	differently	ADV	RB	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6089
# text = Whereas activation of the HIV-1 enhancer following T-cell stimulation is mediated largely through binding of the transcription factor NF-kappa B to two adjacent kappa B sites in the HIV-1 long terminal repeat, activation of the HIV-2 enhancer in monocytes and T cells is dependent on four cis-acting elements: a single kappa B site, two purine-rich binding sites, PuB1 and PuB2, and a pets site.
1	Whereas	whereas	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
10	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	largely	largely	ADV	RB	_	_	_	_	_
16	through	through	ADV	RB	_	_	_	_	_
17	binding	binding	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	two	two	NUM	CD	NumType=Card	_	_	_	_
28	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
38	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
39	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	2	2	NUM	CD	NumType=Card	_	_	_	_
47	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	T	t	NOUN	NN	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
53	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
54	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
55	on	on	ADP	IN	_	_	_	_	_
56	four	four	NUM	CD	NumType=Card	_	_	_	_
57	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
59	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	:	:	PUNCT	:	_	_	_	_	_
61	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
63	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
64	B	b	NOUN	NN	Number=Sing	_	_	_	_
65	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	,	,	PUNCT	,	_	_	_	_	_
67	two	two	NUM	CD	NumType=Card	_	_	_	_
68	purine-rich	purine-rich	NOUN	NN	Number=Sing	_	_	_	_
69	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
70	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
71	,	,	PUNCT	,	_	_	_	_	_
72	PuB1	Pub1	NOUN	NN	Number=Sing	_	_	_	_
73	and	and	CCONJ	CC	_	_	_	_	_
74	PuB2	Pub2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	and	and	CCONJ	CC	_	_	_	_	_
77	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
78	pets	pet	NOUN	NN	Number=Sing	_	_	_	_
79	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
80	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6090
# text = We have now identified a novel cis-acting element within the HIV-2 enhancer, immediately upstream of the kappa B site, designated peri-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	immediately	immediately	ADV	RB	_	_	_	_	_
18	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6091
# text = This site is conserved among isolates of HIV-2 and the closely related simian immunodeficiency virus, and transfection assays show this site to mediate HIV-2 enhancer activation following stimulation of monocytic but not T-cell lines.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	among	among	ADP	IN	_	_	_	_	_
6	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	closely	closely	ADV	RB	_	_	_	_	_
14	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
15	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
21	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
22	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
27	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	not	not	ADV	RB	_	_	_	_	_
38	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6092
# text = This is the first description of an HIV-2 enhancer element which displays such monocyte specificity, and no comparable enhancer element has been clearly defined for HIV-1.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	description	description	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
17	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	no	no	DET	DT	_	_	_	_	_
21	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	clearly	clearly	ADV	RB	_	_	_	_	_
27	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6093
# text = While a nuclear factor(s) from both peripheral blood monocytes and T cells binds the peri-kappa B site, electrophoretic mobility shift assays suggest that either a different protein binds to this site in monocytes versus T cells or that the protein recognizing this enhancer element undergoes differential modification in monocytes and T cells, thus supporting the transfection data.
1	While	while	SCONJ	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	s	s	X	AFX	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
23	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
24	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
25	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
26	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	either	either	DET	DT	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	versus	versus	ADP	IN	_	_	_	_	_
39	T	T	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	that	that	SCONJ	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	recognizing	recognize	VERB	VBG	VerbForm=Ger	_	_	_	_
46	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
47	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
48	element	element	NOUN	NN	Number=Sing	_	_	_	_
49	undergoes	undergo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
51	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	T	t	NOUN	NN	Number=Sing	_	_	_	_
56	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	thus	thus	ADV	RB	_	_	_	_	_
59	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
62	data	data	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6094
# text = Further, while specific constitutive binding to the peri-kappa B site is seen in monocytes, stimulation with phorbol esters induces additional, specific binding.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	constitutive	constitutive	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
21	induces	induce	ADV	RB	_	_	_	_	_
22	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6095
# text = Understanding the monocyte-specific function of the peri-kappa B factor may ultimately provide insight into the different role monocytes and T cells play in HIV pathogenesis.
1	Understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	peri-kappa	peri-kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	ultimately	ultimately	ADV	RB	_	_	_	_	_
13	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
14	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
26	pathogenesis	pathogenesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6096
# text = Document 003001590 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001590	003001590	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6097
# text = Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins.
1	Suppressive	Suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6098
# text = BACKGROUND: Studies from our laboratory have shown that the earliest stages of atherosclerosis may be mediated by an autoimmune reaction against heat shock protein 60 (Hsp60).
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
12	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
21	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
22	against	against	ADP	IN	_	_	_	_	_
23	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
24	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	60	60	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6099
# text = The interactions of Hsp60-specific T cells with arterial endothelial cells (EC) require expression of both Hsp60 and certain adhesion molecules shown to be induced simultaneously in EC by mechanical and other types of stress.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	arterial	arterial	ADJ	JJ	Degree=Pos	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	Hsp60	Hsp60	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
22	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
35	types	type	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6100
# text = Recently, it was shown that suppression of T cell-mediated immune responses by cyclosporin A (CyA) enhanced atherosclerotic lesion formation in mice.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
14	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
17	A	a	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
23	lesion	lesion	NOUN	NN	Number=Sing	_	_	_	_
24	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6101
# text = In contrast, aspirin was found to lower the risk of myocardial infarction in men.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	lower	lower	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
13	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	men	man	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6102
# text = These conflicting observations may be due to different effects of anti-inflammatory agents on adhesion molecule and Hsp expression in EC, respectively.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	conflicting	conflicting	ADJ	JJ	Degree=Pos	_	_	_	_
3	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	due	due	ADP	IN	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Hsp	Hsp	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6103
# text = MATERIAL AND METHODS:
1	MATERIAL	material	NOUN	NN	Number=Sing	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 6104
# text = In the present study, we analyzed the effects of CyA, aspirin, and indomethacin on T cell proliferation using a proliferation assay.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CyA	Cya	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	indomethacin	indomethacin	ADV	RB	_	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
24	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6105
# text = To explore the expression of adhesion molecules, monocyte chemoattractant protein-1 (MCP-1), and Hsp60 in human umbilical vein endothelial cells (HUVECs), Northern blot analyses were used.
1	To	to	PART	TO	_	_	_	_	_
2	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
24	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
32	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
33	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6106
# text = To examine the activation status of the transcription factors nuclear factor kappaB (NF-kappaB) and heat shock factor-1 (HSF-1), electrophoretic mobility shift assays were performed.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	status	status	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
20	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	HSF	Hsf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
30	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
31	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
32	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6107
# text = RESULTS: With the exception of indomethacin, the used immunosuppressive and anti-inflammatory agents significantly inhibited T cell proliferation in response to influenza virus antigen in a dose-dependent manner.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	With	with	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	indomethacin	indomethacin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	used	use	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	influenza	influenza	ADJ	JJ	Degree=Pos	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	antigen	antigen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6108
# text = Interestingly, CyA and indomethacin did not suppress tumor necrosis factor-alpha (TNF-alpha)-induced adhesion molecule expression on HUVECs, whereas aspirin had an inhibitory effect.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	indomethacin	indomethacin	ADV	RB	_	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
21	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	HUVECs	Huvecs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
28	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
31	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6109
# text = These observations correlated with the modulation of NF-kappaB activity in EC.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6110
# text = All agents tested induced expression of Hsp60 6 hr after application.
1	All	all	DET	DT	_	_	_	_	_
2	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	_
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	application	application	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6111
# text = In addition, aspirin and indomethacin, but not CyA, induced Hsp70 expression in HUVECs that correlated with induction of HSF-1 activity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	aspirin	aspirin	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	indomethacin	indomethacin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	Hsp70	Hsp70	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	HSF	HSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6112
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 6113
# text = Our results show that the tested agents (except indomethacin) are inhibitors of the T cell-mediated immune response, as expected, that aspirin is an effective suppressor of adhesion molecule expression, and that all three agents can induce Hsp60 in HUVECs.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	except	except	ADP	IN	_	_	_	_	_
10	indomethacin	indomethacin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
31	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
34	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	that	that	SCONJ	IN	_	_	_	_	_
39	all	all	DET	DT	_	_	_	_	_
40	three	three	NUM	CD	NumType=Card	_	_	_	_
41	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
42	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
43	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
44	Hsp60	Hsp60	PROPN	NNP	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6114
# text = These data provide the molecular basis for the notion that (1) part of the anti-atherogenic effect of aspirin may be due to the prevention of the adhesion of sensitized T cells to stressed EC; (2) that part of the atherosclerosis-promoting effect of CyA may be due to its potential as an inducer of Hsp60 expression and its inability to down-regulate adhesion molecule expression on EC; and (3) that down-regulation of MCP-1 expression by aspirin may result in decreased recruitment of monocytes into the arterial intima beneath stressed EC.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	1	1	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	part	part	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	anti-atherogenic	anti-atherogenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	due	due	ADP	IN	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	sensitized	sensitize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	stressed	stress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	2	2	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	part	part	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
48	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	_
51	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
52	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
53	due	due	ADP	IN	_	_	_	_	_
54	to	to	ADP	IN	_	_	_	_	_
55	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
56	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
57	as	as	ADP	IN	_	_	_	_	_
58	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	Hsp60	Hsp60	NUM	CD	NumType=Card	_	_	_	_
62	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
65	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
66	to	to	ADP	IN	_	_	_	_	_
67	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
70	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
71	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
72	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
73	on	on	ADP	IN	_	_	_	_	_
74	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	;	;	PUNCT	,	_	_	_	_	_
76	and	and	CCONJ	CC	_	_	_	_	_
77	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
78	3	3	X	LS	_	_	_	_	SpaceAfter=No
79	)	)	PUNCT	-RRB-	_	_	_	_	_
80	that	that	SCONJ	IN	_	_	_	_	_
81	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
82	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
83	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
84	of	of	ADP	IN	_	_	_	_	_
85	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
86	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
87	1	1	NUM	CD	NumType=Card	_	_	_	_
88	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
89	by	by	ADP	IN	_	_	_	_	_
90	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
91	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
92	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
93	in	in	ADP	IN	_	_	_	_	_
94	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
95	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
96	of	of	ADP	IN	_	_	_	_	_
97	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
98	into	into	ADP	IN	_	_	_	_	_
99	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
100	arterial	arterial	ADJ	JJ	Degree=Pos	_	_	_	_
101	intima	intima	NOUN	NN	Number=Sing	_	_	_	_
102	beneath	beneath	ADP	IN	_	_	_	_	_
103	stressed	stress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
104	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
105	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6115
# text = Document 003001595 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001595	003001595	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6116
# text = Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains.
1	Distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
2	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	chaperone	chaperone	NOUN	NN	Number=Sing	_	_	_	_
7	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	dioxin	dioxin	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
16	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	PAS	Pas	NOUN	NN	Number=Sing	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6117
# text = The intracellular dioxin receptor mediates signal transduction by dioxin and functions as a ligand-activated transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	dioxin	dioxin	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
7	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	dioxin	dioxin	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6118
# text = It contains a basic helix-loop-helix (bHLH) motif contiguous with a Per-Arnt-Sim (PAS) homology region.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
5	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	bHLH	bHLH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
12	contiguous	contiguous	ADJ	JJ	Degree=Pos	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	Per-	per-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	Arnt	Arnt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Sim	Sim	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PAS	PAS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6119
# text = In extracts from nonstimulated cells the receptor is recovered in an inducible cytoplasmic form associated with the 90-kDa heat shock protein (hsp90), a molecular chaperone.
1	In	in	ADP	IN	_	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	nonstimulated	nonstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	recovered	recover	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	form	form	NOUN	NN	Number=Sing	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
21	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
22	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
30	chaperone	chaperone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6120
# text = We have reconstituted ligand-dependent activation of the receptor to a DNA-binding form by using the dioxin receptor and its bHLH-PAS partner factor
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	dioxin	dioxin	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	PAS	Pas	NOUN	NN	Number=Sing	_	_	_	_
27	partner	partner	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6121
# text = Arnt expressed by in vitro translation in reticulocyte lysate.
1	Arnt	Arnt	NOUN	NN	Number=Sing	_	_	_	_
2	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
6	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	reticulocyte	reticulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
9	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6122
# text = Deletion of the PAS domain of the receptor resulted in constitutive dimerization with Arnt.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PAS	PAS	PROPN	NNP	Number=Sing	_	_	_	_
5	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
12	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Arnt	Arnt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6123
# text = In contrast, this receptor mutant showed low levels of xenobiotic response element-binding activity, indicating that the PAS domain may be important for DNA-binding affinity and/or specificity of the receptor.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	xenobiotic	xenobiotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	PAS	Pas	NOUN	NN	Number=Sing	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	or	or	CCONJ	CC	_	_	_	_	_
34	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6124
# text = It was not possible to reconstitute dioxin receptor function with proteins expressed in wheat germ lysate.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	reconstitute	reconstitute	VERB	VB	VerbForm=Inf	_	_	_	_
7	dioxin	dioxin	ADP	IN	_	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	wheat	wheat	NOUN	NN	Number=Sing	_	_	_	_
15	germ	germ	NOUN	NN	Number=Sing	_	_	_	_
16	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6125
# text = In line with these observations, reticulocyte lysate but not wheat germ lysate promoted the association of de novo synthesized dioxin receptor with hsp90.
1	In	in	ADP	IN	_	_	_	_	_
2	line	line	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	observations	observation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	reticulocyte	reticulocyte	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
8	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	wheat	wheat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	germ	germ	NOUN	NN	Number=Sing	_	_	_	_
13	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
14	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	association	association	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	de	de	PROPN	NNP	Number=Sing	_	_	_	_
19	novo	novo	ADV	RB	_	_	_	_	_
20	synthesized	synthesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	dioxin	dioxin	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6126
# text = At least two distinct domains of the receptor mediated interaction with hsp90: the ligand-binding domain located within the PAS region and, surprisingly, the bHLH domain.
1	At	at	ADV	RB	_	_	_	_	_
2	least	least	ADV	RBS	Degree=Sup	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
19	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	PAS	Pas	PROPN	NNP	Number=Sing	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	bHLH	bhlh	ADJ	JJ	Degree=Pos	_	_	_	_
30	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6127
# text = Whereas ligand-binding activity correlated with association with hsp90, bHLH-hsp90 interaction appeared to be important for DNA-binding activity but not for dimerization of the receptor.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	association	association	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	_
15	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
16	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6128
# text = Several distinct roles for hsp90 in modulating dioxin receptor function are therefore likely: correct folding of the ligand-binding domain, interference with Arnt heterodimerization, and folding of a DNA-binding conformation of the bHLH domain.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	_
6	in	in	SCONJ	IN	_	_	_	_	_
7	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	dioxin	dioxin	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	therefore	therefore	ADV	RB	_	_	_	_	_
13	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	correct	correct	ADJ	JJ	Degree=Pos	_	_	_	_
16	folding	folding	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	Arnt	Arnt	PROPN	NNP	Number=Sing	_	_	_	_
27	heterodimerization	heterodimerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	folding	folding	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
36	conformation	conformation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	bHLH	bHLH	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
40	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6129
# text = Thus, the dioxin receptor system provides a complex and interesting model of the regulation of transcription factors by hsp90.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	dioxin	dioxin	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	system	system	NOUN	NN	Number=Sing	_	_	_	_
7	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	interesting	interesting	ADJ	JJ	Degree=Pos	_	_	_	_
12	model	model	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6130
# text = Document 003001600 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001600	003001600	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6131
# text = New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation.
1	New	new	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
4	PNU156804	PNU156804	NOUN	NN	Number=Sing	_	_	_	_
5	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6132
# text = We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
8	undecylprodigiosin	undecylprodigiosin	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	UP	UP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6133
# text = We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	action	action	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
12	analogue	analogue	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	UP	UP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	PNU156804	PNU156804	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	more	more	ADV	RBR	_	_	_	_	_
22	favorable	favorable	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	UP	up	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6134
# text = We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PNU156804	PNU156804	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	UP	Up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	PNU156804	PNU156804	NUM	CD	NumType=Card	_	_	_	_
18	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	mid-late	mid-late	ADJ	JJ	Degree=Pos	_	_	_	_
25	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	as	as	SCONJ	IN	_	_	_	_	_
28	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
32	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	cyclins	cyclin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
42	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
45	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6135
# text = In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	PNU156804	PNU156804	PROPN	NNP	Number=Sing	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	either	either	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	T	t	NOUN	NN	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6136
# text = We have investigated several molecular pathways that are known to be activated by IL-2 in T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6137
# text = We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	PNU156804	PNU156804	PROPN	NNP	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6138
# text = On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	PNU156804	PNU156804	PROPN	NNP	Number=Sing	_	_	_	_
7	efficiently	efficiently	ADV	RB	_	_	_	_	_
8	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6139
# text = PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta.
1	PNU156804	PNU156804	NUM	CD	NumType=Card	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	due	due	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
20	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
21	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6140
# text = PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes.
1	PNU156804	PNU156804	NOUN	NN	Number=Sing	_	_	_	_
2	action	action	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	some	some	DET	DT	_	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	;	;	PUNCT	,	_	_	_	_	_
10	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
30	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6141
# text = We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	prodigiosin	prodigiosin	ADJ	JJ	Degree=Pos	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
19	target	target	NOUN	NN	Number=Sing	_	_	_	_
20	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
21	clearly	clearly	ADV	RB	_	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
27	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
28	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
29	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	cyclosporin	cyclosporin	ADP	IN	_	_	_	_	_
32	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6142
# text = Document 003001605 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001605	003001605	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6143
# text = Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	RFX1	RFX1	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	MIBP1	MIBP1	PROPN	NNP	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	core	core	NOUN	NN	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6144
# text = The negative regulatory element (NRE) of the hepatitis B virus (HBV) core promoter contains three subregions which act synergistically to suppress core promoter activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	HBV	HBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	core	core	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	three	three	NUM	CD	NumType=Card	_	_	_	_
20	subregions	subregion	NOUN	NNS	Number=Plur	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	synergistically	synergistically	ADV	RB	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
26	core	core	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6145
# text = One of these subregions, NRE gamma, is active in both HeLa cervical carcinoma cells and Huh7 hepatoma cells and was found to be bound by a protein factor present in both cell types.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	subregions	subregion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	_
7	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
14	cervical	cervical	ADJ	JJ	Degree=Pos	_	_	_	_
15	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Huh7	Huh7	NUM	CD	NumType=Card	_	_	_	_
19	hepatoma	hepatoma	NOUN	NN	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=1|Tense=Past|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	both	both	DET	DT	_	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6146
# text = Here we show that the transcription factor RFX1 can bind to NRE gamma and transactivate the core promoter through this site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	RFX1	rfx1	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	NRE	NRE	VERB	VB	VerbForm=Inf	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	core	core	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6147
# text = Mutations which abrogated the gene-suppressive activity of NRE gamma prevented RFX1 from binding to NRE gamma.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	which	which	PRON	WDT	PronType=Rel	_	_	_	_
3	abrogated	abrogate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	_
11	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
12	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	RFX1	RFX1	PROPN	NNP	Number=Sing	_	_	_	_
14	from	from	SCONJ	IN	_	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	_
18	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6148
# text = In addition, RFX1 can bind simultaneously, most likely as a heterodimer, with the transcription factor MIBP1 to NRE gamma.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	RFX1	RFX1	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
7	simultaneously	simultaneously	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	most	most	ADV	RBS	_	_	_	_	_
10	likely	likely	ADV	RB	_	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	MIBP1	Mibp1	PROPN	NNP	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	NRE	Nre	VERB	VB	VerbForm=Inf	_	_	_	_
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6149
# text = In the absence of a cloned MIBP1 gene for further studies, we hypothesize that RFX1 acts with MIBP1 to negatively regulate the core promoter activity through the NRE gamma site.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	MIBP1	Mibp1	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
11	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	hypothesize	hypothesize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	RFX1	RFX1	PROPN	NNP	Number=Sing	_	_	_	_
17	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	MIBP1	Mibp1	PROPN	NNP	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	negatively	negatively	ADV	RB	_	_	_	_	_
22	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	core	core	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6150
# text = The ability of RFX1 to transactivate the core promoter raises the possibility that RFX1 may play a dual role in regulating HBV gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RFX1	RFX1	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	raises	rais	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	RFX1	RFX1	PROPN	NNP	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
19	role	role	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	SCONJ	IN	_	_	_	_	_
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	HBV	HBV	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6151
# text = Document 003001611 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001611	003001611	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6152
# text = Danazol decreases transcription of estrogen receptor gene in human monocytes.
1	Danazol	Danazol	PROPN	NNP	Number=Sing	_	_	_	_
2	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6153
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6154
# text = Administration of danazol for over one month reduced the levels of estrogen receptor (ER) and its mRNA to approximately 50 and 20%, respectively in monocytes.
1	Administration	Administration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	danazol	danazol	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	over	over	ADV	RB	_	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	month	month	NOUN	NN	Number=Sing	_	_	_	_
8	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
19	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	approximately	approximately	VERB	VB	VerbForm=Inf	_	_	_	_
23	50	50	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	respectively	respectively	ADV	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6155
# text = 2.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6156
# text = Danazol did not alter the degradation rate of ER mRNA in monocytes.
1	Danazol	Danazol	PROPN	NNP	Number=Sing	_	_	_	_
2	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
7	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	ER	er	NOUN	NN	Number=Sing	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6157
# text = 3. Danazol decreased the transcription rate of ER gene to approximately 50% in monocytes in a run-on assay.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Danazol	Danazol	PROPN	NNP	Number=Sing	_	_	_	_
4	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	ER	er	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	on	on	ADP	IN	_	_	_	_	_
22	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6158
# text = 4. Danazol may release estrogen predominance via the reduction of transcription for ER gene, which leads to the reduction of ER mRNA and ER expressions in monocytes.
1	4	4	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Danazol	Danazol	PROPN	NNP	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
6	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
7	predominance	predominance	NOUN	NN	Number=Sing	_	_	_	_
8	via	via	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	ER	er	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	ER	er	NOUN	NN	Number=Sing	_	_	_	_
24	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	ER	er	NOUN	NN	Number=Sing	_	_	_	_
27	expressions	expression	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6159
# text = Document 003001613 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001613	003001613	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6160
# text = Cross-linking of CD30 induces HIV expression in chronically infected T cells.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	HIV	haHive	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	chronically	chronically	ADV	RB	_	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6161
# text = CD30, a member of the tumor necrosis factor (TNF) receptor family, is expressed constitutively on the surface of the human T cell line ACH-2, which is chronically infected with human immunodeficiency virus type-1 (HIV)-1.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	member	member	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	constitutively	constitutively	ADV	RB	_	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	_
28	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Int	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	chronically	chronically	ADV	RB	_	_	_	_	_
35	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
39	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
40	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6162
# text = We demonstrate that cross-linking CD30 with an anti-CD30-specific monoclonal antibody, which mimics the described biological activities of the CD30 ligand (CD30L), results in HIV expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
6	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	anti-CD30	anti-CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	mimics	mimics	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
19	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CD30L	Cd30l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	results	result	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6163
# text = CD30 cross-linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not mediated by endogenous TNF alpha/beta.
1	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
7	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	ACH	ACH	DET	DT	_	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
24	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6164
# text = Furthermore, cross-linking of CD30 leads to NF-kappa B activation and enhanced HIV transcription.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cross	cross	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
4	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
7	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6165
# text = Thus, CD30-CD30L interactions mediate the induction of HIV expression by a kappa B-dependent pathway that is independent of TNF.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD30-CD30L	Cd30-cd30l	ADJ	JJ	Degree=Pos	_	_	_	_
4	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
5	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6166
# text = This mechanism may be important in the activation of HIV expression from latently infected CD4+
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	latently	latently	ADV	RB	_	_	_	_	_
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 6167
# text = T cells, especially in lymphoid organs where cell to cell contact is conducive to receptor-ligand interactions.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	especially	especially	ADV	RB	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	organs	organ	NOUN	NNS	Number=Plur	_	_	_	_
8	where	where	ADV	WRB	PronType=Rel	_	_	_	_
9	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
12	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	conducive	conducive	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	receptor	receptor	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
19	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6168
# text = Document 003001619 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001619	003001619	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6169
# text = An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	intricate	intricate	ADJ	JJ	Degree=Pos	_	_	_	_
3	arrangement	arrangement	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	SCONJ	IN	_	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6170
# text = alpha 4 integrins mediate cell-cell and cell-extracellular matrix interactions that are critical for maturation and function of the immune system as well as differentiation of skeletal muscle.
1	alpha	alpha	ADV	RB	_	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	_
4	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	function	function	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADV	RB	_	_	_	_	_
26	well	well	ADV	RB	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	skeletal	skeletal	ADJ	JJ	Degree=Pos	_	_	_	_
31	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6171
# text = Here we examine molecular mechanisms controlling the pattern of alpha 4 expression.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	examine	examine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	alpha	alpha	ADV	RB	_	_	_	_	_
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6172
# text = The activity of constructs containing 5' deletion mutants of the alpha 4 gene promoter was compared in transfection assays into cell lines that express alpha 4 and cell lines that do not.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	``	_	_	_	_	_
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
20	assays	assays	ADV	RB	_	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	alpha	alpha	ADV	RB	_	_	_	_	_
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	do	do	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6173
# text = The sequence between position -42 and -76 base pairs (bp) was required for efficient transcription in cells that express alpha 4, but it showed no activity in HeLa cells, which do not express alpha 4.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	position	position	NOUN	NN	Number=Sing	_	_	_	_
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	42	42	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	76	76	NUM	CD	NumType=Card	_	_	_	_
10	base	base	NOUN	NN	Number=Sing	_	_	_	_
11	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	alpha	alpha	ADV	RB	_	_	_	_	_
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
29	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	no	no	DET	DT	_	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
40	alpha	alpha	ADP	IN	_	_	_	_	_
41	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6174
# text = Three binding sites for the Ets family of transcription factors are found in this region: two adjacent sites at positions -50 and -54 bp and a more 5' site at position -67 bp.
1	Three	three	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	50	50	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	54	54	NUM	CD	NumType=Card	_	_	_	_
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
31	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	'	'	PUNCT	``	_	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	position	position	NOUN	NN	Number=Sing	_	_	_	_
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	67	67	NUM	CD	NumType=Card	_	_	_	_
38	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6175
# text = Using a series of constructs containing deletions and mutations in this region, we found that the 3'-most site alone was sufficient for binding GA-binding protein alpha (GABP alpha)/GABP beta and for a low level of transcriptional activation.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	series	series	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	alone	alone	ADV	RB	_	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	GA	ga	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	GABP	Gabp	NOUN	NN	Number=Sing	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
39	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
44	level	level	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6176
# text = When all three sites were present, a second complex "a" was detected, which contains an unknown member of the Ets family.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	three	three	NUM	CD	NumType=Card	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
12	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	"	"	PUNCT	''	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Int	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
21	member	member	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Ets	et	PROPN	NNPS	Number=Plur	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6177
# text = Formation of complex a was cell-type specific and correlated with a high level of transcription.
1	Formation	Formation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6178
# text = Deletion of the 5'-most Ets site had no effect on binding to GABP alpha/GABP beta, but it eliminated a.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
8	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
20	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	eliminated	eliminate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6179
# text = Concomitant with this loss of a, a new Ets-1-containing complex "c" appeared.
1	Concomitant	Concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
10	Ets	Ets	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
16	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	"	"	PUNCT	''	_	_	_	_	_
19	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6180
# text = Complex c substituted efficiently for complex a in transcriptional activation.
1	Complex	complex	NOUN	NN	Number=Sing	_	_	_	_
2	c	care	NOUN	NN	Number=Sing	_	_	_	_
3	substituted	substitute	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	efficiently	efficiently	ADV	RB	_	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	complex	complex	NUM	CD	NumType=Card	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6181
# text = We conclude that although neither of the two 5'-most Ets sites alone binds nuclear protein, they appear to act as modulators which control the pattern of Ets proteins that bind the alpha 4 gene promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	although	although	SCONJ	IN	_	_	_	_	_
5	neither	neither	DET	DT	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
13	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	alone	alone	ADV	RB	_	_	_	_	_
16	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	modulators	modulator	NOUN	NNS	Number=Plur	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	4	4	NUM	CD	NumType=Card	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6182
# text = This arrangement of Ets sites, coupled with the tissue- and developmental-specific expression of Ets members, likely play a key role in defining the pattern of alpha 4 integrin.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	arrangement	arrangement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	likely	likely	ADV	RB	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	SCONJ	IN	_	_	_	_	_
27	defining	define	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	alpha	alpha	ADV	RB	_	_	_	_	_
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6183
# text = Document 003001620 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001620	003001620	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6184
# text = Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation.
1	Kappa	Kappa	PROPN	NNP	Number=Sing	_	_	_	_
2	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	differentially	differentially	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
16	oxidation	oxidation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6185
# text = Kappa B
1	Kappa	Kappa	PROPN	NNP	Number=Sing	_	_	_	_
2	B	B	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6186
# text = (kappa
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6187
# text = B) enhancer binding proteins isolated from the nuclei of activated human T cells produce two distinct nucleoprotein complexes when incubated with the kappa B element from the interleukin-2 receptor-alpha (IL-2R alpha) gene.
1	B	b	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
18	nucleoprotein	nucleoprotein	NOUN	NN	Number=Sing	_	_	_	_
19	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6188
# text = These two DNA-protein complexes are composed of at least four host proteins (p50, p55, p75, p85), each of which shares structural similarity with the v-rel oncogene product.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	at	at	ADV	RB	_	_	_	_	_
11	least	least	ADV	RBS	Degree=Sup	_	_	_	_
12	four	four	NUM	CD	NumType=Card	_	_	_	_
13	host	host	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	p55	p55	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	p75	p75	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	p85	p85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	each	each	DET	DT	_	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Int	_	_	_	_
28	shares	share	NOUN	NNS	Number=Plur	_	_	_	_
29	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
30	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
34	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
35	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
36	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6189
# text = Nuclear expression of these proteins is induced with distinctly biphasic kinetics following phorbol ester activation of T cells (p55/p75 early and p50/p85 late).
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	distinctly	distinctly	ADV	RB	_	_	_	_	_
10	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
11	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
14	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	p55	p55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	p75	p75	NOUN	NN	Number=Sing	_	_	_	_
23	early	early	ADV	RB	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	p50/	p50/	SYM	SYM	_	_	_	_	SpaceAfter=No
26	p85	p85	NUM	CD	NumType=Card	_	_	_	_
27	late	late	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6190
# text = DNA-protein crosslinking studies have revealed that the more rapidly migrating B2 complex contains both p50 and p55 while the more slowly migrating B1 complex is composed of p50, p55, p75, and p85.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	crosslinking	crosslink	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	more	more	ADV	RBR	_	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	migrating	migrating	VERB	VBG	VerbForm=Ger	_	_	_	_
12	B2	b2	NUM	CD	NumType=Card	_	_	_	_
13	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
14	contains	contain	NOUN	NNS	Number=Plur	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p55	p55	NOUN	NN	Number=Sing	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	more	more	ADV	RBR	_	_	_	_	_
22	slowly	slowly	ADV	RB	_	_	_	_	_
23	migrating	migrating	VERB	VBG	VerbForm=Ger	_	_	_	_
24	B1	b1	NUM	CD	NumType=Card	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	p55	p55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	p75	p75	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	p85	p85	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6191
# text = Site-directed mutagenesis of the wild-type IL-2R alpha kappa B enhancer (GGGGAATCTCCC) has revealed that the binding of p50 and p55 (B2 complex) is particularly sensitive to alteration of the 5' triplet of deoxyguanosine residues.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	GGGGAATCTCCC	GGGGAATCTCCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p55	p55	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	B2	b2	NUM	CD	NumType=Card	_	_	_	_
31	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	particularly	particularly	ADV	RB	_	_	_	_	_
35	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	'	'	PUNCT	``	_	_	_	_	_
42	triplet	triplet	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	deoxyguanosine	deoxyguanosine	NOUN	NN	Number=Sing	_	_	_	_
45	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6192
# text = In contrast, formation of the B1 complex, reflecting the binding of p75 and p85, critically depends upon the more 3' sequences of this enhancer element.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	reflecting	reflecte	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p75	p75	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	p85	p85	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	critically	critically	ADV	RB	_	_	_	_	_
19	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	upon	upon	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	'	'	PUNCT	``	_	_	_	_	_
25	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6193
# text = DNA binding by all four of these Rel-related factors is blocked by selective chemical modification of lysine and arginine residues, suggesting that both of these basic amino acids are required for binding to the kappa B element.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	all	all	DET	DT	_	_	_	_	_
5	four	four	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	Rel-related	Rel-relate	ADJ	JJ	Degree=Pos	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
14	chemical	chemical	ADJ	JJ	Degree=Pos	_	_	_	_
15	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lysine	lysine	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
20	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
28	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
29	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	SCONJ	IN	_	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6194
# text = Similarly, covalent modification of free sulfhydryl groups with diamide (reversible) or N-ethylmaleimide (irreversible) results in a complete loss of DNA binding activity.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	covalent	covalent	ADJ	JJ	Degree=Pos	_	_	_	_
4	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
7	sulfhydryl	sulfhydryl	NOUN	NN	Number=Sing	_	_	_	_
8	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	diamide	diamide	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	N	not	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	ethylmaleimide	ethylmaleimide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	irreversible	irreversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	results	result	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
25	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6195
# text = In contrast, mild oxidation with glucose oxidase selectively inhibits p75 and p85 binding while not blocking p50 and p55 interactions.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mild	mild	ADJ	JJ	Degree=Pos	_	_	_	_
5	oxidation	oxidation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	glucose	glucose	NOUN	NN	Number=Sing	_	_	_	_
8	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	p75	p75	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	p85	p85	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
18	p50	p50	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	p55	p55	NUM	CD	NumType=Card	_	_	_	_
21	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6196
# text = These findings suggest that reduced cysteine thiols play an important role in the DNA binding activity of this family of Rel-related transcription factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
7	thiols	thiol	NOUN	NNS	Number=Plur	_	_	_	_
8	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Rel-	Rel-	X	GW	_	_	_	_	SpaceAfter=No
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6197
# text = Document 003001626 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001626	003001626	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6198
# text = Involvement of tyrosine phosphorylation in endothelial adhesion molecule induction.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6199
# text = Induction of endothelial adhesion molecules by the cytokine tumor necrosis factor-alpha (TNF) can occur independently of protein kinase C and activation of a protein tyrosine kinase (PTK) has recently been implicated in the upregulation of vascular cell adhesion molecule 1 (VCAM-1) by interleukin-4 (IL-4) on endothelial cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
19	independently	independently	ADV	RB	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	C	c	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	recently	recently	ADV	RB	_	_	_	_	_
36	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
45	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	1	1	X	LS	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	by	by	ADP	IN	_	_	_	_	_
53	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
55	4	4	NUM	CD	NumType=Card	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	on	on	ADP	IN	_	_	_	_	_
62	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
63	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6200
# text = We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin, as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	PTK	Ptk	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
7	herbimycin	herbimycin	ADP	IN	_	_	_	_	_
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	_
11	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6201
# text = Inhibition studies indicate that specific tyrosine phosphorylation following PTK activation is involved in the mobilization of the transcription factor, nuclear factor kappa B, and VCAM-1 mRNA expression.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	PTK	PTK	NUM	CD	NumType=Card	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6202
# text = This may have implications for pathophysiological conditions that involve the upregulation of these molecules (e.g.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
4	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	pathophysiological	pathophysiological	ADJ	JJ	Degree=Pos	_	_	_	_
7	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	e.g.	e.g.	X	FW	_	_	_	_	_

# sent_id = 6203
# text = inflammation and atherosclerosis).
1	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6204
# text = Document 003001627 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001627	003001627	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6205
# text = Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma.
1	Nonpituitary	Nonpituitary	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	prolactin	prolactin	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Pit	pit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	differentially	differentially	ADV	RB	_	_	_	_	_
14	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
20	stroma	stroma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6206
# text = Expression of the human PRL (hPRL) gene in extrapituitary sites such as the uterus (decidualized endometrial stroma and myometrium) and cells of the hematopoietic lineage is directed by an alternative promoter which is located approximately 6 kilobases (kb) upstream of the pituitary-specific start site.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	PRL	PRL	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	hPRL	hPRL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	extrapituitary	extrapituitary	ADJ	JJ	Degree=Pos	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	uterus	uterus	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	decidualized	decidualize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
20	stroma	stroma	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	myometrium	myometrium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
29	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	approximately	approximately	ADV	RB	_	_	_	_	_
40	6	6	NUM	CD	NumType=Card	_	_	_	_
41	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
51	start	start	NOUN	NN	Number=Sing	_	_	_	_
52	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6207
# text = In order to delineate the tissue-specific mechanisms governing the control of nonpituitary PRL gene expression, we have cloned and sequenced 3 kb
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	governing	govern	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nonpituitary	nonpituitary	ADJ	JJ	Degree=Pos	_	_	_	_
15	PRL	PRL	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	sequenced	sequence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6208
# text = 5'-flanking DNA of the upstream decidual/lymphoid (dPRL) promoter.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
9	decidual	decidual	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	dPRL	dPRL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6209
# text = Based on sequence homology we identified two binding motifs for Pit-1 and seven half-sites for glucocorticoid receptor/progesterone receptor (PR) binding.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Pit	pit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	seven	seven	NUM	CD	NumType=Card	_	_	_	_
16	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PR	pr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6210
# text = We focused our studies on the role of Pit-1 and of PR as potential transcriptional regulators, since the POU domain protein Pit-1 is essential in the control of pituitary PRL expression, and progesterone induces decidual transformation of the endometrial stroma, a differentiation process during which the decidual PRL gene is activated.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	focused	focus	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	PR	pr	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	since	since	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	POU	POU	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	_
35	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
41	decidual	decidual	ADJ	JJ	Degree=Pos	_	_	_	_
42	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
46	stroma	stroma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
50	process	process	NOUN	NN	Number=Sing	_	_	_	_
51	during	during	ADP	IN	_	_	_	_	_
52	which	which	PRON	WDT	PronType=Rel	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	decidual	decidual	ADJ	JJ	Degree=Pos	_	_	_	_
55	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	_
56	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
57	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
58	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6211
# text = We demonstrate in a variety of cell types, including lymphocytes and endometrial stroma, that Pit-1 is not involved in the regulation of dPRL promoter/reporter gene constructs carrying 3 kb 5'-flanking DNA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
14	stroma	stroma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	Pit	pit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	dPRL	dprl	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
33	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
34	3	3	NUM	CD	NumType=Card	_	_	_	_
35	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
36	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6212
# text = Our experiments also show that activated PR does not confer direct transcriptional control on the dPRL promoter.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	PR	pr	NOUN	NN	Number=Sing	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
11	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	dPRL	dprl	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6213
# text = When we compared the activity of the transfected dPRL promoter in PRL-secreting and nonsecreting lymphoid cells, we found that the 3 kb 5'-flanking region of the dPRL promoter did not contain elements restricting expression to only those lymphocytes that produce PRL but allowed expression of fusion reporter genes irrespective of the status of the endogenous PRL gene.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	dPRL	dprl	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	PRL	PRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	secreting	secret	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	nonsecreting	nonsecret	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
30	region	region	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	dPRL	dPRL	PROPN	NNP	Number=Sing	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
38	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
39	restricting	restrict	VERB	VBG	VerbForm=Ger	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	only	only	ADV	RB	_	_	_	_	_
43	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
44	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
45	that	that	PRON	WDT	PronType=Rel	_	_	_	_
46	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	PRL	Prl	NOUN	NN	Number=Sing	_	_	_	_
48	but	but	CCONJ	CC	_	_	_	_	_
49	allowed	allowed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
53	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
54	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
55	irrespective	irrespective	ADV	RB	_	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	status	status	NOUN	NN	Number=Sing	_	_	_	_
59	of	of	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
62	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	_
63	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6214
# text = This was in sharp contrast to endometrial cells where 3 kb 5'-flanking DNA conferred strong transcriptional activation on the dPRL promoter in decidualized endometrial stromal cells actively secreting PRL, but did not allow transcription in undifferentiated non-PRL-secreting endometrial stromal cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	sharp	sharp	ADJ	JJ	Degree=Pos	_	_	_	_
5	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	where	where	ADV	WRB	PronType=Rel	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	dPRL	dprl	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	decidualized	decidualized	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
28	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	actively	actively	ADV	RB	_	_	_	_	_
31	secreting	secrete	VERB	VBG	VerbForm=Ger	_	_	_	_
32	PRL	PRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
41	non-PRL	non-prl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	secreting	secret	VERB	VBG	VerbForm=Ger	_	_	_	_
44	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
45	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6215
# text = Activation of the dPRL promoter construct in these undifferentiated cells could however be induced by the addition of cAMP, in the absence of progesterone, suggesting that a signal transduced through the cAMP signaling pathway is a primary inducer of decidual PRL gene expression.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	dPRL	dPRL	PROPN	NNP	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	however	however	ADV	RB	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
31	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	through	through	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
35	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
36	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
40	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	decidual	decidual	ADJ	JJ	Degree=Pos	_	_	_	_
43	PRL	PRL	NOUN	NN	Number=Sing	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
45	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6216
# text = Document 003001631 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001631	003001631	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6217
# text = HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
7	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	adults	adult	NOUN	NNS	Number=Plur	_	_	_	_
14	upon	upon	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
17	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
18	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	CDR2	Cdr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6218
# text = HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	infects	infects	NOUN	NNS	Number=Plur	_	_	_	_
5	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
6	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
7	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
8	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
16	state	state	NOUN	NN	Number=Sing	_	_	_	_
17	until	until	ADP	IN	_	_	_	_	_
18	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6219
# text = We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	gp120-anti-gp120	gp120-anti-gp120	NUM	CD	NumType=Card	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	heat	heat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	inactivated	inactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	iHIV	ihiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	X	LS	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
34	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
37	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6220
# text = In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	iHIV	iHIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	strictly	strictly	ADV	RB	_	_	_	_	_
24	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
34	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6221
# text = Moreover, we further investigated the physiologic relevance of these observations.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
8	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	observations	observation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6222
# text = When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	submitted	submit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
7	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	_
8	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	iHIV	iHIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	PBMCs	Pbmcs	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
27	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6223
# text = This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	'	's	PART	POS	_	_	_	_	_
16	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6224
# text = Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies).
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
7	PBMCs	Pbmcs	NOUN	NNS	Number=Plur	_	_	_	_
8	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	specifically	specifically	ADV	RB	_	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	CDR2	Cdr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	D1	d1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
38	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	anti-CD4	anti-CD4	NUM	CD	NumType=Card	_	_	_	_
41	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
42	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6225
# text = In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
10	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
11	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	D1	d1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	D1/CDR3	D1/CDR3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6226
# text = Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	sCD4	sCD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	D1/CDR2	D1/CDR2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
15	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6227
# text = Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	events	event	NOUN	NNS	Number=Plur	_	_	_	_
8	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	D1/CDR2	D1/cdr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
28	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6228
# text = Document 003001633 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001633	003001633	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6229
# text = Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.
1	Glycation	Glycation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
7	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	HIT	Hit	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6230
# text = Prolonged poor glycemic control in non-insulin-dependent diabetes mellitus patients often leads to a decline in insulin secretion from pancreatic beta cells, accompanied by a decrease in the insulin content of the cells.
1	Prolonged	Prolong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	poor	poor	ADJ	JJ	Degree=Pos	_	_	_	_
3	glycemic	glycemic	ADJ	JJ	Degree=Pos	_	_	_	_
4	control	control	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	non-insulin	non-insulin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	_
10	mellitus	mellitus	CCONJ	CC	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	often	often	ADV	RB	_	_	_	_	_
13	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
19	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
32	content	content	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6231
# text = As a step toward elucidating the pathophysiological background of the so-called glucose toxicity to pancreatic beta cells, we induced glycation in HIT-T15 cells using a sugar with strong deoxidizing activity, D-ribose, and examined the effects on insulin gene transcription.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	step	step	NOUN	NN	Number=Sing	_	_	_	_
4	toward	toward	SCONJ	IN	_	_	_	_	_
5	elucidating	elucidat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	pathophysiological	pathophysiological	ADJ	JJ	Degree=Pos	_	_	_	_
8	background	background	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	glucose	glucose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	toxicity	toxicity	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HIT	Hit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	15	15	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	sugar	sugar	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
35	deoxidizing	deoxidizing	NOUN	NN	Number=Sing	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	D-	d-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	ribose	ribose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
47	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
48	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6232
# text = The results of reporter gene analyses revealed that the insulin gene promoter is more sensitive to glycation than the control beta-actin gene promoter; approximately 50 and 80% of the insulin gene promoter activity was lost when the cells were kept for 3 d in the presence of 40 and 60 mM
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
7	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	more	more	ADV	RBR	_	_	_	_	_
15	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	actin	actin	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	approximately	approximately	ADV	RB	_	_	_	_	_
28	50	50	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	when	when	ADV	WRB	PronType=Int	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	kept	keep	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	for	for	ADP	IN	_	_	_	_	_
46	3	3	NUM	CD	NumType=Card	_	_	_	_
47	d	would	PROPN	NNP	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	40	40	NUM	CD	NumType=Card	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	60	60	NUM	CD	NumType=Card	_	_	_	_
55	mM	mm	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6233
# text = D-ribose, respectively.
1	D-	D-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	ribose	ribose	PRON	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6234
# text = In agreement with this, decrease in the insulin mRNA and insulin content was observed in the glycation-induced cells.
1	In	in	ADP	IN	_	_	_	_	_
2	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
13	content	content	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6235
# text = Also, gel mobility shift analyses using specific antiserum revealed decrease in the DNA-binding activity of an insulin gene transcription factor, PDX-1/IPF1/STF-1.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	gel	gel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	PDX	PDX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1/IPF1/STF	-1/IPF1/STF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6236
# text = These effects of D-ribose seemed almost irreversible but could be prevented by addition of 1 mM aminoguanidine or 10 mM N-acetylcysteine, thus suggesting that glycation and reactive oxygen species, generated through the glycation reaction, serve as mediators of the phenomena.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	D-	d-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	ribose	ribose	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
6	seemed	seem	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	almost	almost	ADV	RB	_	_	_	_	_
8	irreversible	irreversible	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	mM	mm	NOUN	NN	Number=Sing	_	_	_	_
18	aminoguanidine	aminoguanidine	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	mM	mm	NOUN	NN	Number=Sing	_	_	_	_
22	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
31	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
32	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	through	through	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
38	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	serve	serve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	as	as	SCONJ	IN	_	_	_	_	_
42	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	phenomena	phenomena	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6237
# text = These observations suggest that protein glycation in pancreatic beta cells, which occurs in vivo under chronic hyperglycemia, suppresses insulin gene transcription and thus can explain part of the beta cell glucose toxicity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	glycation	glycation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	DET	WDT	PronType=Int	_	_	_	_
13	occurs	occurs	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
16	under	under	ADP	IN	_	_	_	_	_
17	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
18	hyperglycemia	hyperglycemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	_
21	insulin	insulin	ADP	IN	_	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	_
26	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
27	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
28	part	part	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	glucose	glucose	NOUN	NN	Number=Sing	_	_	_	_
34	toxicity	toxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6238
# text = Document 003001634 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001634	003001634	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6239
# text = Lactobacilli and vaginal host defense: activation of the human immunodeficiency virus type 1 long terminal repeat, cytokine production, and NF-kappaB.
1	Lactobacilli	Lactobacilli	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
4	host	host	NOUN	NN	Number=Sing	_	_	_	_
5	defense	defense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6240
# text = Lactobacilli, a component of the normal vaginal flora, can activate the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR) in the Jurkat T lymphocyte and THP-1 macrophage cell lines.
1	Lactobacilli	Lactobacilli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	component	component	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
9	flora	flora	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6241
# text = Activation of the LTR in Jurkat cells was strongly enhanced by vanadate and inhibited by catalase, implicating H2O2.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	strongly	strongly	ADV	RB	_	_	_	_	_
10	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6242
# text = In contrast, activation in THP-1 cells occurred in the absence of vanadate and was unaffected by catalase.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6243
# text = The active material partitioned into the phenol layer on hot aqueous phenol extraction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	material	material	NOUN	NN	Number=Sing	_	_	_	_
4	partitioned	partition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	phenol	phenol	NOUN	NN	Number=Sing	_	_	_	_
8	layer	layer	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	hot	hot	ADJ	JJ	Degree=Pos	_	_	_	_
11	aqueous	aqueous	ADJ	JJ	Degree=Pos	_	_	_	_
12	phenol	phenol	NOUN	NN	Number=Sing	_	_	_	_
13	extraction	extraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6244
# text = Lactobacilli also increased tumor necrosis factor-alphaand interleukin-1betaproduction and activated NF-kappaB in THP-1 cells and increased tumor necrosis factor-alphaproduction by human monocytes.
1	Lactobacilli	Lactobacilli	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alphaand	alphaand	NOUN	NN	Number=Sing	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	betaproduction	betaproduction	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	THP	THP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-alphaproduction	-alphaproduction	NOUN	NN	Number=Sing	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6245
# text = Human vaginal fluid specimens had comparable properties, which correlated with their bacterial content.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
3	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
4	specimens	specimen	NOUN	NNS	Number=Plur	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
7	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
14	content	content	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6246
# text = These findings suggest the presence in vaginal fluid of agent(s) derived from indigenous bacteria that can activate the HIV-1 LTR, cytokine production, and NF-kappaB in cells of macrophage lineage, with possible influence on vaginal physiology and host defense.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
8	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	agent	agent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	s	s	X	AFX	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	indigenous	indigenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
38	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	with	with	SCONJ	IN	_	_	_	_	_
41	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
42	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
43	on	on	ADP	IN	_	_	_	_	_
44	vaginal	vaginal	ADJ	JJ	Degree=Pos	_	_	_	_
45	physiology	physiology	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	host	host	NOUN	NN	Number=Sing	_	_	_	_
48	defense	defense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6247
# text = Document 003001639 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001639	003001639	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6248
# text = Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
26	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6249
# text = Tax corresponds to a 40-kDa transforming protein from the pathogenic retrovirus human T-cell leukemia virus type 1 (HTLV-1) that activates nuclear expression of the NF-kappaB/Rel family of transcription factors by an unknown mechanism.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	corresponds	correspond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
8	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenic	pathogenic	NOUN	NN	Number=Sing	_	_	_	_
13	retrovirus	retrovirus	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
37	family	family	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
44	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6250
# text = Tax expression promotes N-terminal phosphorylation and degradation of IkappaB alpha, a principal cytoplasmic inhibitor of NF-kappaB.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	promotes	promote	NOUN	NNS	Number=Plur	_	_	_	_
4	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	principal	principal	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6251
# text = Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in response to tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) stimulation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
10	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
16	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	normally	normally	ADV	RB	_	_	_	_	_
27	phosphorylate	phosphorylate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	IkappaB	Ikappab	ADJ	JJ	Degree=Pos	_	_	_	_
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	serines	serine	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
42	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	_
59	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6252
# text = In contrast, a mutant of Tax termed M22, which does not induce NF-kappaB, fails to activate either IKKalpha or IKKbeta.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
8	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	M22	m22	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
22	either	either	CCONJ	CC	_	_	_	_	_
23	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6253
# text = Furthermore, endogenous IKK enzymatic activity was significantly elevated in HTLV-1-infected and Tax-expressing T-cell lines.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
5	enzymatic	enzymatic	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6254
# text = Transfection of kinase-deficient mutants of IKKalpha and IKKbeta into either human Jurkat T or 293 cells also inhibits NF-kappaB-dependent reporter gene expression induced by Tax.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	either	either	DET	DT	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	293	293	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6255
# text = Similarly, a kinase-deficient mutant of NIK (NF-kappaB-inducing kinase), which represents an upstream kinase in the TNF-alpha and IL-1 signaling pathways leading to IKKalpha and IKKbeta activation, blocks Tax induction of NF-kappaB.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	inducing	induce	ADJ	JJ	Degree=Pos	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
34	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
35	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
43	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
44	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6256
# text = However, plasma membrane-proximal elements in these proinflammatory cytokine pathways are apparently not involved since dominant negative mutants of the TRAF2 and TRAF6 adaptors, which effectively block signaling through the cytoplasmic tails of the TNF-alpha and IL-1 receptors, respectively, do not inhibit Tax induction of NF-kappaB.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
4	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	apparently	apparently	ADV	RB	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
17	since	since	SCONJ	IN	_	_	_	_	_
18	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	TRAF2	TRAF2	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
26	adaptors	adaptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	effectively	effectively	ADV	RB	_	_	_	_	_
30	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
31	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
32	through	through	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
35	tails	tail	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	do	do	AUX	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
50	not	not	PART	RB	_	_	_	_	_
51	inhibit	inhibit	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
52	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
53	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6257
# text = Together, these studies demonstrate that HTLV-1 Tax exploits a distal part of the proinflammatory cytokine signaling cascade leading to induction of NF-kappaB.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
11	exploits	exploit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
14	part	part	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
20	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
21	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6258
# text = The pathological alteration of this cytokine pathway leading to NF-kappaB activation by Tax may play a central role in HTLV-1-mediated transformation of human T cells, clinically manifested as the adult T-cell leukemia.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
3	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	clinically	clinically	ADV	RB	_	_	_	_	_
34	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
38	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6259
# text = Document 003001644 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001644	003001644	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6260
# text = A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B7.1	b7.1	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6261
# text = The costimulatory molecule B7.1 provides a second signal critical for T cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	B7.1	b7.1	NOUN	NN	Number=Sing	_	_	_	_
5	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6262
# text = The distribution of this integral membrane protein is restricted to certain tissues where its level of expression is modulated by multiple exogenous stimuli.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	integral	integral	ADJ	JJ	Degree=Pos	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
12	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
13	where	where	ADV	WRB	PronType=Rel	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
15	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
23	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
24	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6263
# text = To identify the molecular basis for specificity and inducibility, the chromatin configuration of the human B7.1 gene was examined in intact nuclei from various cell types.
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
13	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B7.1	b7.1	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
23	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6264
# text = The identification of a tissue-specific deoxyribonuclease I hypersensitive site approximately 3kb upstream of the transcription start site led to the characterization of a cell type-specific enhancer region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	deoxyribonuclease	deoxyribonuclease	NOUN	NN	Number=Sing	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	hypersensitive	hypersensitive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	start	start	NOUN	NN	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6265
# text = This 183-bp region was both cell type specific and responsive to two distinct stimuli, lipopolysaccharide and dibutyryl cAMP, known to regulate B7.1 expression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	183	183	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
16	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	dibutyryl	dibutyryl	NOUN	NN	Number=Sing	_	_	_	_
21	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	B7.1	B7.1	NUM	CD	NumType=Card	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6266
# text = Deletional and site-directed mutagenesis revealed the presence of multiple functionally critical cis elements within this region, one of which was a nuclear factor (NF)-kappaB consensus sequence.
1	Deletional	Deletional	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	mutagenesis	mutagenesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
12	functionally	functionally	ADV	RB	_	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
15	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
32	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
33	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6267
# text = In B7.1-positive B cells, this element bound several members of the NF-kappaB family, transcription factors already implicated in signal transduction pathways relevant to B7.1 expression.
1	In	in	ADP	IN	_	_	_	_	_
2	B7.1	B7.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	members	member	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	already	already	ADV	RB	_	_	_	_	_
23	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
27	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
28	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	B7.1	B7.1	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6268
# text = This is the first description, to our knowledge, of regulatory elements that control expression of a gene encoding a B7 costimulatory molecule.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	description	description	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
9	knowledge	knowledge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	B7	B7	NUM	CD	NumType=Card	_	_	_	_
23	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6269
# text = Document 003001645 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001645	003001645	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6270
# text = Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
14	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
15	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6271
# text = Although case-oriented evidence for an association of Epstein-Barr virus (EBV) with gastric carcinoma has been accumulating recently, the interaction(s) between EBV and gastric epithelial cells is/are largely unknown.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	case	case	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	oriented	oriented	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	association	association	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
19	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	accumulating	accumulate	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
23	recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	s	s	X	AFX	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
34	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	largely	largely	ADV	RB	_	_	_	_	_
40	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6272
# text = In this study, we examined seven EBV-positive gastric carcinoma tissues for viral gene expression at the mRNA level, from which studies on the EBV oncogenicity in human epithelial cells will benefit.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	seven	seven	NUM	CD	NumType=Card	_	_	_	_
8	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
12	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
13	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
29	oncogenicity	oncogenicity	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
35	benefit	benefit	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6273
# text = Reverse transcription-PCR analysis showed that all seven EBV-positive tumour tissues constitutively expressed EBV nuclear antigen (EBNA) 1 mRNA, but not EBNA2 mRNA.
1	Reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	seven	seven	ADJ	JJ	Degree=Pos	_	_	_	_
10	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
14	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
15	constitutively	constitutively	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	not	not	ADV	RB	_	_	_	_	_
28	EBNA2	EBNA2	NUM	CD	NumType=Card	_	_	_	_
29	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6274
# text = The EBNA transcription was initiated from one of three EBNA promoters, Qp: by contrast, both Cp and Wp were silent, thus resulting in the lack of EBNA2 mRNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Qp	Qp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Wp	Wp	PROPN	NNP	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	_
26	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	EBNA2	EBNA2	NUM	CD	NumType=Card	_	_	_	_
32	mRNA.	mRNA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6275
# text = Latent membrane protein (LMP) 2A mRNA was detected in three of seven cases; however, neither LMP1 nor LMP2B mRNA was detected in any of the tumours tested.
1	Latent	Latent	ADJ	JJ	Degree=Pos	_	_	_	_
2	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	A	a	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	three	three	NUM	CD	NumType=Card	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	seven	seven	NUM	CD	NumType=Card	_	_	_	_
16	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	neither	neither	CCONJ	CC	_	_	_	_	_
21	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
22	nor	nor	CCONJ	CC	_	_	_	_	_
23	LMP2	LMP2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	any	any	DET	DT	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	tumours	tumour	NOUN	NNS	Number=Plur	_	_	_	_
33	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6276
# text = Transcripts from the BamHI-A region of the viral genome were detectable in all cases.
1	Transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
11	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6277
# text = BZLF1 mRNA and the product, an immediate-early gene for EBV replication, was not expressed in any of them, thereby suggesting that the tumour cells carried EBV genomes in a tightly latent form.
1	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	any	any	DET	DT	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	thereby	thereby	ADV	RB	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
32	genomes	genome	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	tightly	tightly	ADV	RB	_	_	_	_	_
36	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
37	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6278
# text = These findings further extended our previous data regarding EBV latency in gastric carcinoma cells at the protein level, and have affirmed that the programme of viral gene expression in the tumour more closely resembles 'latency I' represented by Burkitt's lymphoma than 'latency II' represented by the majority of nasopharyngeal carcinomas.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	extended	extend	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
7	data	data	NOUN	NN	Number=Sing	_	_	_	_
8	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
9	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
10	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	gastric	gastric	ADJ	JJ	Degree=Pos	_	_	_	_
13	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	affirmed	affirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	programme	programme	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
33	more	more	ADV	RBR	_	_	_	_	_
34	closely	closely	ADV	RB	_	_	_	_	_
35	resembles	resemble	NOUN	NNS	Number=Plur	_	_	_	_
36	'	's	PART	POS	_	_	_	_	SpaceAfter=No
37	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
38	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
39	'	'	PUNCT	``	_	_	_	_	_
40	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	's	's	PART	POS	_	_	_	_	_
44	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
45	than	than	ADP	IN	_	_	_	_	_
46	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
47	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
48	II	Ii	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	'	'	PUNCT	''	_	_	_	_	_
50	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
56	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6279
# text = Document 003001650 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001650	003001650	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6280
# text = Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	enhancer	enhancer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6281
# text = The immunomodulatory cytokine IL-4 affects cells of most hemopoietic lineages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	affects	affects	NOUN	NNS	Number=Plur	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
11	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6282
# text = IL-4 is secreted by activated Th2 but not Th1 cells and plays a major role in the immune response by modulating the differentiation of naive Th cells toward the Th2 phenotype.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	Th2	Th2	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
28	Th	th	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	toward	toward	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	Th2	th2	NUM	CD	NumType=Card	_	_	_	_
33	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6283
# text = We have previously identified an enhancer element, PRE-I, that is essential for the function of the human IL-4 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6284
# text = To investigate the mechanisms responsible for tissue-specific expression of the IL-4 gene, we analyzed nuclear factors binding to the PRE-I site and compared the binding activities of these factors to the IL-4 promoter of Th1 and Th2 cells.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
28	site	site	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	4	4	NUM	CD	NumType=Card	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6285
# text = We show that PRE-I interacts with PMA- and PMA/ionomycin-inducible, cyclosporin A-sensitive nuclear factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	PMA/ionomycin	PMA/ionomycin	ADP	IN	_	_	_	_	SpaceAfter=No
13	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
16	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6286
# text = Using anti-C/EBPbeta (NF-IL6), anti-C/EBPdelta (NF-IL6beta), anti-NF-ATc, anti-NF-ATp, anti-Fos, and anti-Jun
1	Using	Using	PROPN	NNP	Number=Sing	_	_	_	_
2	anti-C/EBPbeta	anti-C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	anti-C/EBPdelta	anti-C/EBPdelta	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	anti-NF	anti-NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	anti-NF	anti-NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	anti-Fos	anti-Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	anti-Jun	anti-Jun	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 6287
# text = Abs we demonstrate that the previously identified PRE-I binding factor POS-1 is composed of different transcription factors in different Th cell subsets.
1	Abs	Ab	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	previously	previously	ADV	RB	_	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	Th	th	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6288
# text = In the IL-4-producing
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	producing	producing	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6289
# text = Th0-like human Jurkat and mouse EL-4 cells, POS-1 (designated POS-1a) contains NF-IL6beta and Jun.
1	Th0	Th0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	like	like	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
8	EL	EL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6290
# text = In the mouse Th2 D10 cells and in the human Th2 clones, POS-1 (designated POS-1b) contains NF-IL6beta, Jun, and NF-ATc/p.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
5	D10	D10	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	Th2	Th2	NOUN	NN	Number=Sing	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	ATc/	ATcith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
36	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6291
# text = In contrast, POS-1 was not found in nuclear extracts of human Th1 clones.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	POS	Pos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
16	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6292
# text = These findings suggest that PRE-I may play a role in the differential regulation of IL-4 gene expression levels.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	PRE	pre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6293
# text = Document 003001654 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001654	003001654	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6294
# text = Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6295
# text = To examine the role of protein phosphatases in T cell activation, Jurkat cells were treated with okadaic acid, an inhibitor of type 1 and 2A phosphatases, and nuclear extracts were examined for the presence of AP1 as a measure of early T cell activation.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Jurkat	Jurkat	SCONJ	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
19	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	type	type	NOUN	NN	Number=Sing	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	A	a	NOUN	NN	Number=Sing	_	_	_	_
29	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	measure	measure	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
46	T	t	PROPN	NNP	Number=Sing	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6296
# text = Okadaic acid was found to be a potent inducer of AP1.
1	Okadaic	Okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
9	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	AP1	AP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6297
# text = In contrast to phorbol esters such as phorbol myristate acetate (PMA), the induction of AP1 by okadaic acid occurs predominantly by transcriptional activation of the jun and fos family of proto-oncogenes.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
5	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
6	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
9	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
10	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
22	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
23	predominantly	predominantly	ADV	RB	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6298
# text = Surprisingly, while the addition of phytohemagglutinin further enhanced the induction of AP1, the addition of PMA inhibited it.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
8	further	further	ADV	RB	_	_	_	_	_
9	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
19	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6299
# text = Okadaic acid treatment was found to dramatically increase mRNA transcripts of the jun family of proto-oncogenes including c-jun, junD, and junB and to a lesser extent the fos family including c-fos and fra-1.
1	Okadaic	Okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	dramatically	dramatically	ADV	RB	_	_	_	_	_
8	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
9	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
10	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
18	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
19	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	junD	jund	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
30	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	_
34	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
35	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
36	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	fra	fra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6300
# text = By comparison, PMA is a very inefficient inducer of the jun gene family in Jurkat cells.
1	By	by	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	inefficient	inefficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6301
# text = Similar to its effect on the induction of AP1 by okadaic acid, PMA inhibits the induction of c-jun mRNA by okadaic acid.
1	Similar	similar	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	s	be	PART	POS	_	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
16	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
25	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6302
# text = Transfection of c-jun promoter constructs confirmed the marked difference between PMA and okadaic acid in inducing c-jun transcription.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6303
# text = The induction of AP1 by okadaic acid suggests that protein phosphatases 1 and 2A (PP1 and PP2A) may be involved in T cell activation as important negative regulators of the transcription factor AP1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
8	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	A	a	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PP1	PP1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	PP2	PP2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
37	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6304
# text = Document 003001656 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001656	003001656	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6305
# text = Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anoxia/	anoxia/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
5	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
9	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
12	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6306
# text = The objectives of this study were to (1) determine the time course of neutrophil adhesion to monolayers of human umbilical vein endothelial cells (HUVECs) that were exposed to 60 minutes of anoxia followed by 30 to 600 minutes of reoxygenation and (2) define the mechanisms responsible for both the early (minutes) and late (hours) hyperadhesivity of postanoxic HUVECs to human neutrophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	objectives	objective	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	time	time	NOUN	NN	Number=Sing	_	_	_	_
14	course	course	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
23	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
24	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	60	60	NUM	CD	NumType=Card	_	_	_	_
34	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	anoxia	anoxia	NOUN	NN	Number=Sing	_	_	_	_
37	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	30	30	NUM	CD	NumType=Card	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	600	600	NUM	CD	NumType=Card	_	_	_	_
42	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	2	2	X	LS	_	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
52	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
53	for	for	ADP	IN	_	_	_	_	_
54	both	both	CCONJ	CC	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
62	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
63	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	hyperadhesivity	hyperadhesivity	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	postanoxic	postanoxic	ADJ	JJ	Degree=Pos	_	_	_	_
68	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
69	to	to	ADP	IN	_	_	_	_	_
70	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
71	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6307
# text = The results clearly demonstrate that anoxia/reoxygenation (A/R) leads to a biphasic increase in neutrophil adhesion to HUVECs, with peak responses occurring at 30 minutes (phase 1) and 240 minutes (phase 2) after reoxygenation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	clearly	clearly	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	anoxia/	anoxia/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	A/	A/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
10	R	r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
16	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
25	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
26	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	30	30	NUM	CD	NumType=Card	_	_	_	_
29	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
32	1	1	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	240	240	NUM	CD	NumType=Card	_	_	_	_
36	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
39	2	2	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	after	after	ADP	IN	_	_	_	_	_
42	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6308
# text = Oxypurinol and catalase inhibited phase-1 adhesion, suggesting a role for xanthine oxidase and H2O2.
1	Oxypurinol	Oxypurinol	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	catalase	catalase	VERB	VB	VerbForm=Inf	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	xanthine	xanthine	NOUN	NN	Number=Sing	_	_	_	_
15	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6309
# text = In comparison, platelet activating factor (PAF) contributed to both phases of neutrophil adhesion.
1	In	in	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	platelet	platelet	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	contributed	contribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	phases	phasis	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6310
# text = Anti-intercellular adhesion molecule-1 (ICAM-1) and anti-P-selectin antibodies (monoclonal antibodies [mAbs]) attenuated phase-1 neutrophil adhesion, consistent with roles for constitutively expressed ICAM-1 and enhanced surface expression of preformed P-selectin.
1	Anti-intercellular	Anti-intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	anti-P-	anti-P-	X	GW	_	_	_	_	SpaceAfter=No
13	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
14	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
17	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
18	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	mAbs	mAbs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	constitutively	constitutively	ADV	RB	_	_	_	_	_
34	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	preformed	preform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6311
# text = Phase-2 neutrophil adhesion was attenuated by an anti-E-selectin mAb, indicating a dominant role of this adhesion molecule in the late phase response.
1	Phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	anti-E-	anti-E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
12	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
21	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
25	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6312
# text = Pretreatment with actinomycin D and cycloheximide or with competing ds-oligonucleotides containing the nuclear factor-kappa B or activator protein-1 cognate DNA sequences significantly attenuated phase-2 response, suggesting a role for de novo macromolecule synthesis.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	actinomycin	actinomycin	NOUN	NN	Number=Sing	_	_	_	_
4	D	d	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	with	with	SCONJ	IN	_	_	_	_	_
9	competing	compete	VERB	VBG	VerbForm=Ger	_	_	_	_
10	ds	d	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-oligonucleotides	-oligonucleotides	SCONJ	IN	_	_	_	_	_
12	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	cognate	cognate	NOUN	NN	Number=Sing	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
27	significantly	significantly	ADV	RB	_	_	_	_	_
28	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	de	de	PROPN	NNP	Number=Sing	_	_	_	_
39	novo	novo	ADV	RB	_	_	_	_	_
40	macromolecule	macromolecule	ADJ	JJ	Degree=Pos	_	_	_	_
41	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6313
# text = Surface expression of ICAM-1, P-selectin, and E-selectin on HUVECs correlated with the phase-1 and -2 neutrophil adhesion responses.
1	Surface	surface	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
16	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6314
# text = Collectively, these findings indicate that A/R elicits a two-phase neutrophil-endothelial cell adhesion response that involves transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
8	/R	/r	NOUN	NN	Number=Sing	_	_	_	_
9	elicits	elicit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
14	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6315
# text = Document 003001658 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001658	003001658	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6316
# text = Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	B7	B7	NUM	CD	NumType=Card	_	_	_	_
14	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
15	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6317
# text = We have earlier shown that stimulation of human CD4+ T cells with SEA presented on Chinese hamster ovary (CHO)-DR transfectants coexpressing either B7 or LFA-3 resulted in distinct cytokine profiles.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	earlier	earlier	ADV	RB	_	_	_	_	_
4	shown	shown	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	SEA	SEa	NOUN	NN	Number=Sing	_	_	_	_
15	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
18	hamster	hamster	NOUN	NN	Number=Sing	_	_	_	_
19	ovary	ovary	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	DR	dr	NOUN	NN	Number=Sing	_	_	_	_
25	transfectants	transfectant	NOUN	NNS	Number=Plur	_	_	_	_
26	coexpressing	coexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
27	either	either	CCONJ	CC	_	_	_	_	_
28	B7	B7	NUM	CD	NumType=Card	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
36	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
37	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6318
# text = We now demonstrate that B7, but not LFA-3, strongly costimulated IL-2 transcription and mRNA expression in CD4+ T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	LFA	LFA	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	strongly	strongly	ADV	RB	_	_	_	_	_
14	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	+	+	SYM	SYM	_	_	_	_	_
25	T	t	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6319
# text = Maximal increase in IL-2 transcription was recorded with CHO-DR/B7/LFA-3, suggesting a cooperative effect of B7 and LFA-3 at the transcriptional level.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	recorded	record	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	CHO	Cho	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	DR/B7/LFA	DR/B7/LFA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	B7	B7	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	LFA	LFA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6320
# text = Gel-shift analysis demonstrated that stimulation of CD4+ T cells with CHO-DR and staphylococcal enterotoxin
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	CHO	Cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
19	enterotoxin	enterotoxin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6321
# text = A was sufficient to induce significant amounts of NF-kappa B binding proteins, whereas induction of AP-1 binding proteins required costimulation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6322
# text = LFA-3 induced moderate levels of AP-1, but did not influence the levels of NF-kappa B, while B7 costimulation strongly induced both AP-1 and substantially enhanced NF-kappa B binding proteins.
1	LFA	Lfa	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	while	while	SCONJ	IN	_	_	_	_	_
25	B7	B7	NUM	CD	NumType=Card	_	_	_	_
26	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
27	strongly	strongly	ADV	RB	_	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	substantially	substantially	ADV	RB	_	_	_	_	_
35	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6323
# text = The CHO-DR/B7/LFA-3 triple transfectant induced a further increase in AP-1 and NF-kappa B binding proteins compared with the double transfectants.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CHO	Cho	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	DR/B7/LFA	DR/B7/LFA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	triple	triple	NOUN	NN	Number=Sing	_	_	_	_
8	transfectant	transfectant	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
12	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	double	double	ADJ	JJ	Degree=Pos	_	_	_	_
28	transfectants	transfectant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6324
# text = The level of Oct-1 binding proteins remained similar in all samples.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	all	all	DET	DT	_	_	_	_	_
13	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6325
# text = Super-shift analysis revealed that the NF-kappa B complex of costimulated CD4+ T cells contained large amounts of p50, substantial amounts of p65, and marginal levels of c-Rel proteins.
1	Super	super	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	shift	shift	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	T	t	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	contained	containe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
21	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
26	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	marginal	marginal	ADJ	JJ	Degree=Pos	_	_	_	_
32	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6326
# text = The AP-1 binding proteins contained c-Jun, Jun-D, and Fra-1, but marginal amounts of Jun-B and c-Fos.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-D	-D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Fra	Fra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	marginal	marginal	ADJ	JJ	Degree=Pos	_	_	_	_
21	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	B	B	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6327
# text = Our results indicate distinct effects of B7 and LFA-3 costimulation on the activity of AP-1 and NF-kappa B.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	B7	B7	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6328
# text = These may partly account for the differential effects of B7 and LFA-3 costimulation on IL-2 expression.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	partly	partly	ADV	RB	_	_	_	_	_
4	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	B7	B7	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6329
# text = Document 003001660 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001660	003001660	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6330
# text = The expression of c-fos, c-jun, and c-myc genes is regulated by heat shock in human lymphoid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
19	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6331
# text = The effect of heat shock on the expression of the nuclear protooncogenes c-fos, c-jun, and c-myc was studied in human lymphoid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
5	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	protooncogenes	protooncogene	NOUN	NNS	Number=Plur	_	_	_	_
13	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6332
# text = Heat shock caused an increase in c-fos and c-jun mRNA levels and a decrease in c-myc mRNA levels in pre-B
1	Heat	heat	ADJ	JJ	Degree=Pos	_	_	_	_
2	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
3	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
13	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
25	-B	-B	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6333
# text = (Hyon) and T (DND-41) cell lines as well as in freshly isolated normal human thymocytes.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Hyon	Hyon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	DND	Dnd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	41	41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	freshly	freshly	ADV	RB	_	_	_	_	_
18	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6334
# text = The changes in the mRNA levels of these protooncogenes in Hyon cells were most pronounced at 42 and 43 degrees C; kinetic analysis demonstrated that the changes could be detected within 30 min of heat shock.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	protooncogenes	protooncogene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Hyon	Hyon	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	most	most	ADV	RBS	_	_	_	_	_
15	pronounced	pronounce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	42	42	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	43	43	NUM	CD	NumType=Card	_	_	_	_
20	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
21	C	care	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	kinetic	kinetic	ADJ	JJ	Degree=Pos	_	_	_	_
24	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
25	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
29	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	within	within	ADP	IN	_	_	_	_	_
33	30	30	NUM	CD	NumType=Card	_	_	_	_
34	min	min	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
37	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6335
# text = Altered transcription of c-fos and c-myc genes was the primary effect of heat shock.
1	Altered	alter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
17	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6336
# text = Secondarily, heat shock of Hyon cells stabilized the c-myc mRNA level by increasing its half-life from 24 to 45 min.
1	Secondarily	Secondarily	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
4	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Hyon	Hyon	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	stabilized	stabilize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
12	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	life	life	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	24	24	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	45	45	NUM	CD	NumType=Card	_	_	_	_
24	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6337
# text = The overall effect of heat shock on c-myc mRNA level, however, was a marked inhibition of its transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
6	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
10	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6338
# text = These results demonstrate that the transcription of nuclear protooncogenes is regulated by heat shock indicating a role for nuclear protooncogenes in the stress response of lymphoid cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	protooncogenes	protooncogene	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
14	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
15	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	protooncogenes	protooncogene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6339
# text = Document 003001663 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001663	003001663	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6340
# text = Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.
1	Blockade	Blockade	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	dithiocarbamates	dithiocarbamate	NOUN	NNS	Number=Plur	_	_	_	_
8	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
9	novel	novel	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6341
# text = Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types.
1	Dithiocarbamates	Dithiocarbamates	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	DTCs	Dtcs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	recently	recently	ADV	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	number	number	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6342
# text = Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB inhibitors have been suggested as potential therapeutic drugs for inflammatory diseases.
1	Given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
23	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
28	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
29	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6343
# text = We show here that DTCs inhibited both interleukin 2 (IL-2) synthesis and membrane expression of antigens which are induced during T-cell activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DTCs	Dtcs	PROPN	NNP	Number=Sing	_	_	_	_
6	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6344
# text = This inhibition, which occurred with a parallel activation of c-Jun transactivating functions and expression, was reflected by transfection experiments at the IL-2 promoter level, and involved not only the inhibition of NF-kappaB-driven reporter activation but also that of nuclear factor of activated T cells (NFAT).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
14	transactivating	transactivating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	reflected	reflect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
23	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	_
35	only	only	ADV	RB	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	but	but	CCONJ	CC	_	_	_	_	_
47	also	also	ADV	RB	_	_	_	_	_
48	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
51	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6345
# text = Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1.
1	Accordingly	accordingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	pyrrolidine	pyrrolidine	PROPN	NNP	Number=Sing	_	_	_	_
13	DTC	DTC	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	either	either	DET	DT	_	_	_	_	_
34	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
35	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
36	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
37	plus	plus	CCONJ	CC	_	_	_	_	_
38	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
41	against	against	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	CD3-T	Cd3-t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
47	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
50	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6346
# text = Furthermore, PDTC differentially targeted both NFATp and NFATc family members, inhibiting the transactivation functions of NFATp and mRNA induction of NFATc.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
4	differentially	differentially	ADV	RB	_	_	_	_	_
5	targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6347
# text = Strikingly, Western blotting and immunocytochemical experiments indicated that PDTC promoted a transient and rapid shuttling of NFATp and NFATc, leading to their accelerated export from the nucleus of activated T cells.
1	Strikingly	strikingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
4	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	immunocytochemical	immunocytochemical	ADJ	JJ	Degree=Pos	_	_	_	_
7	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
8	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
11	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
16	shuttling	shuttling	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	accelerated	accelerated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	export	export	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6348
# text = We propose that the activation of an NFAT kinase by PDTC could be responsible for the rapid shuttling of the NFAT, therefore transiently converting the sustained transactivation of this transcription factor that occurs during lymphocyte activation, and show that c-Jun NH2-terminal kinase (JNK) can act by directly phosphorylating NFATp.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	PDTC	Pdtc	PROPN	NNP	Number=Sing	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
18	shuttling	shuttling	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	therefore	therefore	ADV	RB	_	_	_	_	_
24	transiently	transiently	ADV	RB	_	_	_	_	_
25	converting	converte	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	during	during	ADP	IN	_	_	_	_	_
36	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
43	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
44	NH2	Nh2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
47	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
52	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
53	by	by	SCONJ	IN	_	_	_	_	_
54	directly	directly	ADV	RB	_	_	_	_	_
55	phosphorylating	phosphorylat	VERB	VBG	VerbForm=Ger	_	_	_	_
56	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6349
# text = In addition, the combined inhibitory effects on NFAT and NF-KB support a potential use of DTCs as immunosuppressants.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
14	support	support	NOUN	NN	Number=Sing	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
17	use	use	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	DTCs	DTC	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6350
# text = Document 003001666 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001666	003001666	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6351
# text = Activation of human macrophages by mechanical ventilation in vitro.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
7	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6352
# text = Positive-pressure mechanical ventilation supports gas exchange in patients with respiratory failure but is also responsible for significant lung injury.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	pressure	pressure	NOUN	NN	Number=Sing	_	_	_	_
4	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
5	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	_
6	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	gas	gas	NOUN	NN	Number=Sing	_	_	_	_
8	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
13	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
20	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
21	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6353
# text = In this study, we have developed an in vitro model in which isolated lung cells can be submitted to a prolonged cyclic pressure-stretching strain resembling that of conventional mechanical ventilation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	submitted	submit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cyclic	cyclic	NOUN	NN	Number=Sing	_	_	_	_
24	pressure	pressure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	stretching	stretching	VERB	VBG	VerbForm=Ger	_	_	_	_
27	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
28	resembling	resembl	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	conventional	conventional	ADJ	JJ	Degree=Pos	_	_	_	_
32	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
33	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6354
# text = In this model, cells cultured on a Silastic membrane were elongated up to 7% of their initial diameter, corresponding to a 12% increase in cell surface.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Silastic	Silastic	ADJ	JJ	Degree=Pos	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	elongated	elongate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	up	up	ADP	RP	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
20	diameter	diameter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6355
# text = The lung macrophage was identified as the main cellular source for critical inflammatory mediators such as tumor necrosis factor-alpha, the chemokines interleukin (IL)-8 and -6, and matrix metalloproteinase-9 in this model system of mechanical ventilation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	source	source	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
13	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
25	interleukin	interleukin	ADV	RB	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	8	8	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	matrix	matrix	NUM	CD	NumType=Card	_	_	_	_
37	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	9	9	NUM	CD	NumType=Card	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	model	model	NOUN	NN	Number=Sing	_	_	_	_
43	system	system	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
46	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6356
# text = These mediators were measured in supernatants from ventilated alveolar macrophages, monocyte-derived macrophages, and promonocytic THP-1 cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	ventilated	ventilate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6357
# text = Nuclear factor-kappaB was found to be activated in ventilated macrophages.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	ventilated	ventilate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6358
# text = Synergistic proinflammatory effects of mechanical stress and molecules such as bacterial endotoxin were observed, suggesting that mechanical ventilation might be particularly deleterious in preinjured or infected lungs.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
6	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
19	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	_
20	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	particularly	particularly	ADV	RB	_	_	_	_	_
23	deleterious	deleterious	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	preinjured	preinjure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6359
# text = Dexamethasone prevented IL-8 and tumor necrosis factor-alpha secretion in ventilated macrophages.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	8	8	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
11	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	ventilated	ventilate	ADJ	JJ	Degree=Pos	_	_	_	_
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6360
# text = Mechanical ventilation induced low levels of IL-8 secretion by alveolar type II-like cells.
1	Mechanical	Mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
2	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6361
# text = Other lung cell types such as endothelial cells, bronchial cells, and fibroblasts failed to produce IL-8 in response to a prolonged cyclic pressure-stretching load.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
15	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	8	8	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cyclic	cyclic	NOUN	NN	Number=Sing	_	_	_	_
27	pressure	pressure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	stretching	stretching	VERB	VBG	VerbForm=Ger	_	_	_	_
30	load	load	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6362
# text = This model is of particular value for exploring physical stress-induced signaling pathways, as well as for testing the effects of novel ventilatory strategies or adjunctive substances aimed at modulating cell activation induced by mechanical ventilation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	model	model	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
6	value	value	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	exploring	explore	VERB	VBG	VerbForm=Ger	_	_	_	_
9	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
10	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	for	for	SCONJ	IN	_	_	_	_	_
19	testing	test	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
24	ventilatory	ventilatory	NOUN	NN	Number=Sing	_	_	_	_
25	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	adjunctive	adjunctive	ADJ	JJ	Degree=Pos	_	_	_	_
28	substances	substance	NOUN	NNS	Number=Plur	_	_	_	_
29	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	at	at	SCONJ	IN	_	_	_	_	_
31	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	mechanical	mechanical	ADJ	JJ	Degree=Pos	_	_	_	_
37	ventilation	ventilation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6363
# text = Document 003001669 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001669	003001669	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6364
# text = Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.
1	Murine	Murine	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
6	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	delta	delof	ADP	IN	Abbr=Yes	_	_	_	_
25	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6365
# text = A family of transcriptional activators has recently been identified in chickens; these transcriptional activators recognize a common consensus motif (WGATAR) through a conserved C4 zinc finger DNA-binding domain.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	recently	recently	ADV	RB	_	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	chickens	chicken	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
16	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
19	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
20	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	WGATAR	WGATAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	through	through	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	C4	c4	NOUN	NN	Number=Sing	_	_	_	_
28	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
29	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6366
# text = One of the members of this multigene family, cGATA-3, is most abundantly expressed in the T-lymphocyte cell lineage.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	members	member	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	multigene	multigene	ADJ	JJ	Degree=Pos	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	cGATA	cGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	most	most	ADV	RBS	_	_	_	_	_
16	abundantly	abundantly	ADV	RB	_	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6367
# text = Analysis of human and murine GATA-3 factors shows a striking degree of amino acid sequence identity and similar patterns of tissue specificity of expression in these three organisms.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
6	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	striking	strike	VERB	VBG	VerbForm=Ger	_	_	_	_
13	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	amino	amino	DET	DT	_	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
21	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
24	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	three	three	NUM	CD	NumType=Card	_	_	_	_
30	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6368
# text = The murine and human factors are abundantly expressed in a variety of human and murine T-cell lines and can activate transcription through a tissue-specific GATA-binding site identified within the human T-cell receptor delta gene enhancer.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	abundantly	abundantly	ADV	RB	_	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	tissue-	tissue-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	within	within	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
38	delta	delof	ADP	IN	Abbr=Yes	_	_	_	_
39	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
40	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6369
# text = We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	infer	infer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	highly	highly	ADV	RB	_	_	_	_	_
17	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vertebrate	vertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6370
# text = Document 003001671 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001671	003001671	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6371
# text = Transforming growth factor-beta suppresses human B lymphocyte
1	Transforming	Transform	VERB	VBG	VerbForm=Ger	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-beta	-beta	NOUN	NN	Number=Sing	_	_	_	_
5	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6372
# text = Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
12	form	form	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_

# sent_id = 6373
# text = Ig mRNA.
1	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6374
# text = Transforming growth factor-beta (TGF-beta) inhibits B cell
1	Transforming	Transform	VERB	VBG	VerbForm=Ger	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	factor-beta	factor-beta	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TGF-	Tgf-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6375
# text = Ig secretion and reduces B cell membrane Ig expression.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
8	Ig	ig	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6376
# text = The addition of TGF-beta to human B lymphocyte cultures stimulated with Staphylococcus aureus Cowan strain I and IL-2 completely inhibited B cell Ig secretion (greater than 90%) and decreased B cell surface IgM, IgD, kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
11	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Staphylococcus	Staphylococcus	PROPN	NNP	Number=Sing	_	_	_	_
15	aureus	aureus	ADP	IN	_	_	_	_	_
16	Cowan	Cowan	PROPN	NNP	Number=Sing	_	_	_	_
17	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	completely	completely	ADV	RB	_	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	Ig	ig	NOUN	NN	Number=Sing	_	_	_	_
28	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
31	than	than	ADP	IN	_	_	_	_	_
32	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
40	IgM	IgM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	IgD	IgD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6377
# text = L chain, and lambda L chain expression.
1	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
2	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	lambda	lambda	PROPN	NNP	Number=Sing	_	_	_	_
6	L	L	PROPN	NNP	Number=Sing	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6378
# text = In contrast, TGF-beta had only minimal effects on two other B cell membrane proteins, HLA-DR and CD20.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	only	only	ADV	RB	_	_	_	_	_
9	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6379
# text = Internal labeling with [35S]methionine and immunoprecipitation with anti-IgM, anti-kappa, and anti-lambda antibodies revealed a striking reduction in kappa
1	Internal	Internal	ADJ	JJ	Degree=Pos	_	_	_	_
2	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	35S	35S	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	methionine	methionine	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
12	-IgM	-Igm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	anti-kappa	anti-kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	anti-lambda	anti-lambda	ADJ	JJ	Degree=Pos	_	_	_	_
18	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
19	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
22	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6380
# text = L chain in the presence of TGF-beta.
1	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
2	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6381
# text = A less pronounced reduction in lambda
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	less	less	ADJ	JJ	Degree=Pos	_	_	_	_
3	pronounced	pronounce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6382
# text = L chain and microH chain was also noted.
1	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
2	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	microH	microh	DET	DT	_	_	_	_	_
5	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6383
# text = Northern blot analysis of RNA purified from B cells treated with TGF-beta for varying time intervals revealed a significant decrease in steady state kappa and lambda
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
6	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	SCONJ	IN	_	_	_	_	_
16	varying	varying	VERB	VBG	VerbForm=Ger	_	_	_	_
17	time	time	NOUN	NN	Number=Sing	_	_	_	_
18	intervals	interval	NOUN	NNS	Number=Plur	_	_	_	_
19	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
25	state	state	NOUN	NN	Number=Sing	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6384
# text = L chain mRNA levels.
1	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
2	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
3	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6385
# text = Furthermore, a significant decrease in the switch from the membrane forms of mu and gamma to their respective secreted forms was noted in the presence of TGF-beta.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
12	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
20	secreted	secret	ADJ	JJ	Degree=Pos	_	_	_	_
21	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6386
# text = Nuclear run-on experiments demonstrated decreased transcription of kappa L chain.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	L	L	PROPN	NNP	Number=Sing	_	_	_	_
12	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6387
# text = The effects of TGF-beta on two transcriptional regulatory factors, Oct-2 and nuclear factor (NF) kappa B, known to be important in Ig gene transcription were examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
31	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6388
# text = Oct-2 mRNA levels and both Oct-2 and NF-kappa B proteins in nuclear extracts were not altered by treatment with TGF-beta.
1	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	both	both	CCONJ	CC	_	_	_	_	_
8	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6389
# text = In contrast, levels of the transcriptional factor AP-1, which is not known to be important in B cell
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6390
# text = Ig production, were reduced by TGF-beta.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6391
# text = These findings demonstrate that TGF-beta decreases B lymphocyte
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TGF	Tgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	beta	beta	X	GW	_	_	_	_	_
8	decreases	decrease	X	GW	_	_	_	_	_
9	B	benefit	X	GW	_	_	_	_	_
10	lymphocyte	lymphocyte	X	ADD	_	_	_	_	_

# sent_id = 6392
# text = Ig secretion by inhibiting the synthesis of Ig mRNA and inhibiting the switch from the membrane form to the secreted forms of mu and gamma mRNA.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
26	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6393
# text = The mechanism by which TGF-beta inhibits
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 6394
# text = Ig chain synthesis is unclear although it does not involve inhibition of the binding of NF-kappa B or Oct-2 to their respective target sequences.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
3	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	although	although	SCONJ	IN	_	_	_	_	_
7	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
27	target	target	NOUN	NN	Number=Sing	_	_	_	_
28	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6395
# text = Document 003001673 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001673	003001673	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6396
# text = Temporal control of IgH gene expression in developing B cells by the 3' locus control region.
1	Temporal	Temporal	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IgH	Igh	DET	DT	_	_	_	_	_
5	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	SCONJ	IN	_	_	_	_	_
8	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6397
# text = The suggested roles of the downstream 3' regions acting as a Locus Control Region (LCR), have allowed comparisons to be made between the regulation of the IgH locus with other model systems whose gene expression is governed by LCR activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	PUNCT	''	_	_	_	_	_
9	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
10	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Locus	Locus	PROPN	NNP	Number=Sing	_	_	_	_
14	Control	Control	PROPN	NNP	Number=Sing	_	_	_	_
15	Region	region	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	comparisons	comparison	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	made	make	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
32	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
35	model	model	NOUN	NN	Number=Sing	_	_	_	_
36	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
37	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
38	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	governed	govern	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	LCR	Lcr	ADJ	JJR	Degree=Cmp	_	_	_	_
44	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6398
# text = Here we summarize the importance of the IgH 3'LCR and its putative functional role in IgH gene expression and compare it with the 5'LCR regulatory region of the human beta-globin locus.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	summarize	summarize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	_
9	3'	3's	PART	POS	_	_	_	_	SpaceAfter=No
10	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	IgH	Igh	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	compare	compare	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	5'	5'	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	LCR	Lcr	ADP	IN	_	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	region	region	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
35	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6399
# text = Document 003001683 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001683	003001683	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6400
# text = ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.
1	ERP	Erp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	member	member	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/oncoprotein	/oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
25	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6401
# text = The ets gene family encodes a group of proteins which function as transcription factors under physiological conditions and, if aberrantly expressed, can cause cellular transformation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
3	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	group	group	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	function	function	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	under	under	ADP	IN	_	_	_	_	_
16	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
17	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	if	if	SCONJ	IN	_	_	_	_	_
21	aberrantly	aberrantly	ADV	RB	_	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
26	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6402
# text = We have recently identified two regulatory elements in the murine immunoglobulin heavy-chain (IgH) enhancer, pi and microB, which exhibit striking similarity to binding sites for ets-related proteins.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
11	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
12	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	pi	pi	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	microB	microb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	exhibit	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
27	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	SCONJ	IN	_	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
35	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6403
# text = To identify ets-related transcriptional regulators expressed in pre-B lymphocytes that may interact with either the pi or the microB site, we have used a PCR approach with degenerate oligonucleotides encoding conserved sequences in all members of the ets family.
1	To	to	ADP	IN	_	_	_	_	_
2	identify	identify	ADJ	JJ	Degree=Pos	_	_	_	_
3	ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
11	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	either	either	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	pi	pi	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	microB	microb	PROPN	NNP	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
30	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	degenerate	degenerate	NOUN	NN	Number=Sing	_	_	_	_
33	oligonucleotides	oligonucleotides	NOUN	NNS	Number=Plur	_	_	_	_
34	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
35	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	all	all	DET	DT	_	_	_	_	_
39	members	member	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
43	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6404
# text = We have cloned the gene for a new ets-related transcription factor, ERP (ets-related protein), from the murine pre-B cell line BASC 6C2 and from mouse lung tissue.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
9	ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	ERP	ERP	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
26	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
27	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	_
30	BASC	Basc	NOUN	NN	Number=Sing	_	_	_	_
31	6C2	6c2	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
35	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
36	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6405
# text = The ERP protein contains a region of high homology with the ETS DNA-binding domain common to all members of the ets transcription factor/oncoprotein family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ERP	ERP	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ETS	ets	NOUN	NN	Number=Sing	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
17	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	all	all	DET	DT	_	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	oncoprotein	oncoprotein	ADJ	JJ	Degree=Pos	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6406
# text = Three additional smaller regions show homology to the ELK-1 and SAP-1 genes, a subgroup of the ets gene family that interacts with the serum response factor.
1	Three	Three	NUM	CD	NumType=Card	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	smaller	smaller	ADJ	JJR	Degree=Cmp	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ELK	elk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	SAP	sap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	subgroup	subgroup	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
23	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6407
# text = Full-length ERP expresses only negligible DNA-binding activity by itself.
1	Full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	length	length	NOUN	NN	Number=Sing	_	_	_	_
4	ERP	Erp	NOUN	NN	Number=Sing	_	_	_	_
5	expresses	express	NOUN	NNS	Number=Plur	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	negligible	negligible	ADJ	JJ	Degree=Pos	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6408
# text = Removal of the carboxy terminus enables ERP to interact with a variety of ets-binding sites including the E74 site, the IgH enhancer pi site, and the lck promoter ets site, suggesting a carboxy-terminal negative regulatory domain.
1	Removal	removal	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	_
5	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
6	enables	enable	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	ERP	ERP	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	E74	E74	PROPN	NNP	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	IgH	Igh	ADJ	JJ	Degree=Pos	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	pi	pi	NOUN	NN	Number=Sing	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	lck	lck	NOUN	NN	Number=Sing	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
41	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
42	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
43	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6409
# text = At least three ERP-related transcripts are expressed in a variety of tissues.
1	At	at	ADV	RB	_	_	_	_	_
2	least	least	ADV	RBS	Degree=Sup	_	_	_	_
3	three	three	NUM	CD	NumType=Card	_	_	_	_
4	ERP-	ERP-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6410
# text = However, within the B-cell lineage, ERP is highly expressed primarily at early stages of B-lymphocyte development, and expression declines drastically upon B-cell maturation, correlating with the enhancer activity of the IgH pi site.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	within	within	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	ERP	ERP	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	highly	highly	ADV	RB	_	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	primarily	primarily	ADV	RB	_	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
17	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	declines	decline	NOUN	NNS	Number=Plur	_	_	_	_
27	drastically	drastically	ADV	RB	_	_	_	_	_
28	upon	upon	ADP	IN	_	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	correlating	correlat	VERB	VBG	VerbForm=Ger	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	_
42	pi	pi	NOUN	NN	Number=Sing	_	_	_	_
43	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6411
# text = These data suggest that ERP might play a role in B-cell development and in IgH gene regulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ERP	Erp	PROPN	NNP	Number=Sing	_	_	_	_
6	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
7	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	IgH	Igh	DET	DT	_	_	_	_	_
18	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6412
# text = Document 003001685 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001685	003001685	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6413
# text = Inhibitory effect of growth hormone on TNF-alpha secretion and nuclear factor-kappaB translocation in lipopolysaccharide-stimulated human monocytes.
1	Inhibitory	Inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
5	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
16	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6414
# text = Several studies have pointed to a link between immune and endocrine systems, including a regulatory function of GH on monocyte activation.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	pointed	point	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	link	link	NOUN	NN	Number=Sing	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	immune	immune	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
12	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	GH	GH	PROPN	NNP	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6415
# text = The present study demonstrates that human THP-1 promonocytic cells, engineered by gene transfer to constitutively produce human growth hormone (hGH), secreted depressed amounts of TNF-alpha in response to challenge by LPS.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	engineered	engineer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
16	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	constitutively	constitutively	ADV	RB	_	_	_	_	_
19	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
22	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	hGH	hGh	INTJ	UH	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	secreted	secret	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	depressed	depress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	challenge	challenge	VERB	VB	VerbForm=Inf	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6416
# text = The effect of GH appears to occur in an autocrine fashion, since the inhibitory effect on TNF-alpha secretion by constitutive GH production could be abolished in the presence of anti-hGH mAb.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GH	GH	PROPN	NNP	Number=Sing	_	_	_	_
5	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	autocrine	autocrine	ADJ	JJ	Degree=Pos	_	_	_	_
11	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
24	GH	Gh	NOUN	NN	Number=Sing	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	_
26	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	anti-hGH	anti-hgh	DET	DT	_	_	_	_	_
34	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6417
# text = The GH-induced inhibitory effect was also observed using normal human monocytes and monocyte-derived macrophages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GH	Gh	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6418
# text = Inhibition of TNF-alpha production by THP-1-hGH-transfected cells cultured in the presence of LPS is dependent on a selective pathway, since no inhibition of TNF-alpha production was observed when cells were cultured in the presence of PMA.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	hGH	hGh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
27	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	since	since	SCONJ	IN	_	_	_	_	_
30	no	no	DET	DT	_	_	_	_	_
31	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	when	when	ADV	WRB	PronType=Int	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6419
# text = Inhibition of TNF-alpha secretion by LPS-stimulated THP-1-hGH cells was associated with a decrease in nuclear translocation of nuclear factor-kappaB.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	hGH	hgh	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6420
# text = The capacity of GH to inhibit LPS-induced TNF-alpha production by monocytes without altering other pathways leading to TNF-alpha production may be of potential relevance in septic shock, since GH is available for clinical use.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GH	GH	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	LPS	Lps	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	without	without	SCONJ	IN	_	_	_	_	_
17	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
20	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
30	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
33	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	since	since	SCONJ	IN	_	_	_	_	_
36	GH	GH	PROPN	NNP	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
41	use	use	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6421
# text = Document 003001691 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001691	003001691	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6422
# text = Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL3	IL3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	NOUN	NN	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6423
# text = Role of AP-1- and octamer-binding proteins in control of IL3 gene expression.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6424
# text = We have investigated the molecular and biochemical basis for activation of interleukin 3 (IL3) gene expression in primary human T lymphocytes following CD3 and CD2 receptor stimulation or activation by phytohemagglutinin plus phorbol 12-myristate 13-acetate.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
8	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	NOUN	NN	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
25	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
34	plus	plus	CCONJ	CC	_	_	_	_	_
35	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
36	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
38	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
39	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6425
# text = Using transfection and reporter gene assays specifically designed for primary T lymphocytes in conjunction with gel retardation assays, Western blot analyses and UV cross-linking studies, we found that c-Jun, c-Fos, and octamer-binding proteins play a major role in transcriptional activation of the IL3 gene via their interaction with two specific regions contained within the IL3 5'-flanking sequence.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	designed	design	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
17	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
18	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
21	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
22	analyses	analyse	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	UV	UV	NOUN	NN	Number=Sing	_	_	_	_
25	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
27	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
42	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
43	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
46	role	role	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	_
53	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
54	via	via	ADP	IN	_	_	_	_	_
55	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
56	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
57	with	with	ADP	IN	_	_	_	_	_
58	two	two	NUM	CD	NumType=Card	_	_	_	_
59	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
60	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
61	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	within	within	ADP	IN	_	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	_
65	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
67	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
68	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
69	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6426
# text = Additionally, the region between bases -107 and -59 of the IL3 promoter containing putative AP-2 and Sp1 binding motifs appears necessary for basal level expression of the IL3 gene.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	bases	bas	NOUN	NNS	Number=Plur	_	_	_	_
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	107	107	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	59	59	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL3	IL3	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
25	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6427
# text = The data also indicate that CD2 receptor activation and phytohemagglutinin plus phorbol 12-myristate 13-acetate stimulation augment T cell IL3 gene expression through the same cis- and trans-activating signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	CD2	Cd2	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
11	plus	plus	CCONJ	CC	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
16	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	augment	augment	NOUN	NN	Number=Sing	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
29	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
35	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6428
# text = These results should contribute to a better understanding of the regulation of IL3 gene expression in human T lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
4	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
8	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6429
# text = Document 003001706 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001706	003001706	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6430
# text = Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells.
1	Tcf	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	glycogen	glycogen	ADJ	JJ	Degree=Pos	_	_	_	_
15	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6431
# text = Beta-catenin is the vertebrate homolog of the Drosophila segment polarity gene Armadillo and plays roles in both cell-cell adhesion and transduction of the Wnt signaling cascade.
1	Beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	vertebrate	vertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
7	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
11	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
12	polarity	polarity	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
14	Armadillo	Armadillo	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Wnt	Wnt	PROPN	NNP	Number=Sing	_	_	_	_
29	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
30	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6432
# text = Recently, members of the Lef/Tcf transcription factor family have been identified as protein partners of beta-catenin, explaining how beta-catenin alters gene expression.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	members	member	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Lef	Lef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	partners	partner	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	beta-	beta-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	explaining	explain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	how	how	ADV	WRB	PronType=Int	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	_
27	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
28	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6433
# text = Here we report that in T cells, Tcf-1 also becomes transcriptionally active through interaction with beta-catenin, suggesting that the Wnt signal transduction pathway is operational in T lymphocytes as well.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Wnt	Wnt	ADJ	JJ	Degree=Pos	_	_	_	_
27	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
28	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
29	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	operational	operational	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
35	as	as	ADV	RB	_	_	_	_	_
36	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6434
# text = However, although Wnt signals are known to inhibit the activity of the negative regulatory protein kinase glycogen synthase kinase-3beta (GSK-3beta), resulting in increased levels of beta-catenin, we find no evidence for involvement of GSK-3beta in Tcf-mediated transcription in T cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	Wnt	Wnt	ADJ	JJ	Degree=Pos	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	glycogen	glycogen	NOUN	NN	Number=Sing	_	_	_	_
19	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	GSK	Gsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	beta-	beta-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	catenin	catenin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	no	no	DET	DT	_	_	_	_	_
42	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	GSK	GSK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	T	t	PROPN	NNP	Number=Sing	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6435
# text = That is, a dominant negative GSK-3beta does not specifically activate
1	That	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	GSK	Gsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 6436
# text = Tcf transcription and stimuli (lithium or phytohemagglutinin) that inhibit GSK-3beta activity also do not activate
1	Tcf	Tcf	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	lithium	lithium	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	GSK	GSK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 6437
# text = Tcf reporter genes.
1	Tcf	Tcf	ADJ	JJ	Degree=Pos	_	_	_	_
2	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6438
# text = Thus, inhibition of GSK-3beta is insufficient to activate Tcf-dependent transcription in T lymphocytes.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GSK	GSK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
13	Tcf	Tcf	ADV	RB	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6439
# text = In contrast, in C57MG fibroblast cells, lithium inactivates GSK-3beta and induces Tcf-controlled transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	C57MG	C57MG	ADJ	JJ	Degree=Pos	_	_	_	_
6	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	lithium	lithium	NOUN	NN	Number=Sing	_	_	_	_
10	inactivates	inactivate	NOUN	NNS	Number=Plur	_	_	_	_
11	GSK	GSK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
17	Tcf-	Tcf-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6440
# text = This is the first demonstration that lithium can alter gene expression of Tcf-responsive genes, and points to a difference in regulation of Wnt signaling between fibroblasts and lymphocytes.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	lithium	lithium	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	alter	alter	ADV	RB	_	_	_	_	_
10	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	points	point	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Wnt	Wnt	ADJ	JJ	Degree=Pos	_	_	_	_
27	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
28	between	between	ADP	IN	_	_	_	_	_
29	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6441
# text = Document 003001712 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001712	003001712	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6442
# text = Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
11	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	OTF2	Otf2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6443
# text = The tissue-specific expression of the MOPC 141 immunoglobulin heavy-chain gene was studied by using in vitro transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	MOPC	Mopc	PROPN	NNPS	Number=Plur	_	_	_	_
9	141	141	NUM	CD	NumType=Card	_	_	_	_
10	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
11	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6444
# text = B-cell-specific transcription of this gene was dependent on the octamer element 5'-ATGCAAAG-3', located in the upstream region of this promoter and in the promoters of all other immunoglobulin heavy- and light-chain genes.
1	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	ATGCAAAG	ATGCAAAG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	all	all	DET	DT	_	_	_	_	_
37	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
38	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
39	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	light	light	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
45	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6445
# text = The interaction of purified octamer transcription factors 1 and 2 (OTF1 and OTF2) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OTF1	Otf1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	OTF2	Otf2	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	MOPC	Mopc	NOUN	NN	Number=Sing	_	_	_	_
19	141	141	NUM	CD	NumType=Card	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
25	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6446
# text = Purified OTF1 from HeLa cells and OTF1 and OTF2 from B cells bound to identical sequences within the heavy-chain promoter.
1	Purified	Purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	OTF1	OTF1	PROPN	NNP	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	OTF1	OTF1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	OTF2	OTF2	NUM	CD	NumType=Card	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6447
# text = The OTF interactions we observed extended over the heptamer element 5'-CTCAGGA-3', and it seems likely that the binding of the purified factors involves cooperation between octamer and heptamer sites in this promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	OTF	OTF	ADJ	JJ	Degree=Pos	_	_	_	_
3	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	extended	extend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	over	over	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	heptamer	heptamer	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
13	CTCAGGA	CTCAGGa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	heptamer	heptamer	NOUN	NN	Number=Sing	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6448
# text = In addition to these elements, we identified a second regulatory element, the N element with the sequence 5'-GGAACCTCCCCC-3'.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	N	N	PROPN	NNP	Number=Sing	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
22	-GGAACCTCCCCC	-ggaacctccccc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6449
# text = The N element could independently mediate low levels of transcription in both B-cell and HeLa-cell extracts, and, in conjunction with the octamer element, it can promote high levels of transcription in B-cell extracts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	N	n	PROPN	NNP	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	independently	independently	ADV	RB	_	_	_	_	_
6	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	HeLa	HeLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
31	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
32	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
33	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6450
# text = The N element bound a transcription factor, NTF, that is ubiquitous in cell-type distribution, and NTF was distinct from any of the previously described proteins that bind to similar sequences.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	N	N	PROPN	NNP	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	bound	bound	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NTF	NTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NTF	NTF	PROPN	NNP	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	any	any	DET	DT	_	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	previously	previously	ADV	RB	_	_	_	_	_
29	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
35	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6451
# text = Based on these results, we propose that NTF and OTF2 interactions (both with their cognate DNA elements and possibly at the protein-protein level) may be critical to B-cell-specific expression and that these interactions provide additional pathways for regulating gene expression.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	NTF	NTF	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	OTF2	OTF2	NUM	CD	NumType=Card	_	_	_	_
12	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	both	both	CCONJ	CC	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	possibly	possibly	ADV	RB	_	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	that	that	SCONJ	IN	_	_	_	_	_
39	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
40	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
41	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
42	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
43	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
44	for	for	SCONJ	IN	_	_	_	_	_
45	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
46	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6452
# text = Document 003001713 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001713	003001713	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6453
# text = Fibroblast growth factor-1 (FGF-1) enhances IL-2 production and nuclear translocation of NF-kappaB in FGF receptor-bearing Jurkat T cells.
1	Fibroblast	Fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	FGF	FGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	T	T	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6454
# text = Fibroblast growth factors (FGFs) are heparin-binding proteins crucial to embryogenesis, angiogenesis, and wound healing.
1	Fibroblast	Fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	FGFs	FGF	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	heparin	heparin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	embryogenesis	embryogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	angiogenesis	angiogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	wound	wound	ADJ	JJ	Degree=Pos	_	_	_	_
20	healing	healing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6455
# text = FGF-1 is abundantly expressed in the synovium in rheumatoid arthritis and in rejecting allografts, sites of chronic immune-mediated inflammation.
1	FGF	Fgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	abundantly	abundantly	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	synovium	synovium	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	rejecting	reject	VERB	VBG	VerbForm=Ger	_	_	_	_
16	allografts	allograft	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
21	immune-mediated	immune-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
22	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6456
# text = The frequency of FGF-1-responsive T cells is increased in the peripheral blood of these disorders, and a high percentage of infiltrating T cells in rheumatoid arthritis synovium express receptors for FGF-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
24	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	SCONJ	IN	_	_	_	_	_
26	infiltrating	infiltrat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
31	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
32	synovium	synovium	NOUN	NN	Number=Sing	_	_	_	_
33	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
34	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6457
# text = To understand the action of FGF-1 in T cells, studies were initiated in Jurkat T cells that express the signaling isoform of FGF receptor-1.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6458
# text = These experiments show that FGF-1 stimulation of Jurkat T cells provides a second signal that augments TCR-mediated IL-2 production.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	augments	augment	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	TCR	Tcr	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6459
# text = Analogous to costimulation via CD28, this activity is mediated through activation of Rel/kappaB, a family of transcription factors known to regulate IL-2 and other activation-inducible proteins.
1	Analogous	Analogous	ADP	IN	_	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
4	via	via	ADP	IN	_	_	_	_	_
5	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6460
# text = FGF-1 alone induces modest nuclear translocation of kappaB-binding proteins, and this translocation is enhanced by the combination of anti-CD3 and FGF-1.
1	FGF	Fgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	modest	modest	ADJ	JJ	Degree=Pos	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	FGF	FGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6461
# text = This NF-kappaB binding complex is composed of transcriptionally active p65(RelA)/p50 heterodimers and results primarily from the targeted degradation of IkappaB-alpha, an inhibitor that sequesters Rel/kappaB in the cytoplasm.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
12	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	p50	p50	NUM	CD	NumType=Card	_	_	_	_
18	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	primarily	primarily	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	sequesters	sequester	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6462
# text = These data are the first to show a connection between FGF-1 signaling and NF-kappaB activation outside of embryonic development.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	connection	connection	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	outside	outside	ADP	IN	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
23	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6463
# text = The signaling events that link FGF receptor-1 engagement and NF-kappaB activation in Jurkat are probably distinct from the CD28 costimulation pathway, since FGF-1-induced Rel/kappaB binding proteins do not contain significant levels of c-Rel and are not identical with the CD28 response complex.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	link	link	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	FGF	Fgf	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	probably	probably	ADV	RB	_	_	_	_	_
20	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
24	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	since	since	ADP	IN	_	_	_	_	_
28	FGF	FGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	Rel/	Rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
37	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
40	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
41	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
50	with	with	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
53	response	response	NOUN	NN	Number=Sing	_	_	_	_
54	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6464
# text = Document 003001718 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001718	003001718	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6465
# text = Activation of NF-kappa B by interleukin 2 in human blood monocytes.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6466
# text = We report here that interleukin 2 (IL-2) acts on human blood monocytes by enhancing binding activity of the transcription factor NF-kappa B to its consensus sequence in the 5' regulatory enhancer region of the IL-2 receptor alpha chain (p55).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
32	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	'	's	PUNCT	``	_	_	_	_	_
37	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
38	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
46	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
47	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	p55	p55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6467
# text = Similarly, IL-2 activates NF-kappa B in the human monocytic cell line U 937, but not in resting human T-cells.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
7	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	line	line	NOUN	NN	Number=Sing	_	_	_	_
17	U	U	PROPN	NNP	Number=Sing	_	_	_	_
18	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6468
# text = This effect is detectable within 15 min and peaks 1 h after exposure to IL-2.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	15	15	NUM	CD	NumType=Card	_	_	_	_
7	min	min	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	peaks	peak	NOUN	NNS	Number=Plur	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6469
# text = Enhanced NF-kappa B binding activity is followed by functional activation in that inducibility of the IL-2 receptor alpha chain is mediated by enhanced NF-kappa B binding and that a heterologous promoter containing the NF-kappa B consensus sequence (-291 to -245) of the IL-2 receptor alpha chain gene is activated.
1	Enhanced	enhance	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	that	that	PRON	WDT	PronType=Dem	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	_
44	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
45	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
46	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
47	291	291	NUM	CD	NumType=Card	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	245	245	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	2	2	NUM	CD	NumType=Card	_	_	_	_
57	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
58	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
59	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
60	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
61	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
62	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6470
# text = In addition, IL-2 is capable of increasing transcript levels of the p50 gene coding for the p50 subunit of the NF-kappa B transcription factor, whereas mRNA levels of the p65 NF-kappa B gene remained unchanged.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
11	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
21	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
33	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
37	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
42	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	unchanged	unchang	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6471
# text = Document 003001723 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001723	003001723	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6472
# text = A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	nuclease	nuclease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6473
# text = Analysis of the chromatin organization of the integrated human immunodeficiency virus type 1 (HIV-1) genome has previously revealed a major constitutive DNase I-hypersensitive site associated with the pol gene (E. Verdin, J. Virol.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
5	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	integrated	integrate	ADJ	JJ	Degree=Pos	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	previously	previously	ADV	RB	_	_	_	_	_
22	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
25	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	E.	e.	PROPN	NNP	Number=Sing	_	_	_	_
38	Verdin	Verdin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	J.	J.	PROPN	NNP	Number=Sing	_	_	_	_
41	Virol	Virol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6474
# text = 65:6790-6799, 1991).
1	65:6790-6799	65:6790-6799	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1991	1991	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6475
# text = In the present report, high-resolution mapping of this site with DNase I and micrococcal nuclease identified a nucleosome-free region centered around nucleotides (nt) 4490 to 4766.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
9	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	micrococcal	micrococcal	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclease	nuclease	NOUN	NN	Number=Sing	_	_	_	_
19	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	nucleosome	nucleosome	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	around	around	ADP	IN	_	_	_	_	_
27	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	nt	not	PART	RB	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	4490	4490	NUM	CD	NumType=Card	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	4766	4766	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6476
# text = A 500-bp fragment encompassing this hypersensitive site (nt 4481 to 4982) exhibited transcription-enhancing activity (two- to threefold) when it was cloned in its natural position with respect to the HIV-1 promoter after transient transfection in U937 and CEM cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	500	500	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
6	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	nt	not	PART	RB	_	_	_	_	_
12	4481	4481	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	4982	4982	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	enhancing	enhancing	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	threefold	threefold	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	when	when	ADV	WRB	PronType=Int	_	_	_	_
28	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
34	position	position	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	after	after	ADP	IN	_	_	_	_	_
44	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
45	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	U937	U937	NUM	CD	NumType=Card	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	CEM	cem	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6477
# text = Using in vitro footprinting and gel shift assays, we have identified four distinct binding sites for nuclear proteins within this positive regulatory element.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
4	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
7	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
8	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	four	four	NUM	CD	NumType=Card	_	_	_	_
14	distinct	distinct	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6478
# text = Site B (nt 4519 to 4545) specifically bound four distinct nuclear protein complexes: a ubiquitous factor, a T-cell-specific factor, a B-cell-specific factor, and the monocyte/macrophage- and B-cell-specific transcription factor PU.1/Spi-1.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	_
2	B	b	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	nt	not	PART	RB	_	_	_	_	_
5	4519	4519	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	4545	4545	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	specifically	specifically	ADV	RB	_	_	_	_	_
10	bound	bound	ADP	IN	_	_	_	_	_
11	four	four	NUM	CD	NumType=Card	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
45	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
46	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
47	PU.1/	PU.1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
48	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6479
# text = In most HIV-1 isolates in which this PU box was not conserved, it was replaced by a binding site for the related factor Ets1.
1	In	in	ADP	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	PU	Pu	NOUN	NN	Number=Sing	_	_	_	_
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	Ets1	ets1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6480
# text = Factors binding to site C (nt 4681 to 4701) had a DNA-binding specificity similar to that of factors binding to site B, except for PU.1/Spi-1.
1	Factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	nt	not	PART	RB	_	_	_	_	_
8	4681	4681	NUM	CD	NumType=Card	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	4701	4701	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
18	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	except	except	ADP	IN	_	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	PU.1/	Pu.1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	Spi-1	spi-1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6481
# text = A GC box containing a binding site for Sp1 was identified (nt 4623 to 4631).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
3	box	box	NOUN	NN	Number=Sing	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	nt	not	PART	RB	_	_	_	_	_
14	4623	4623	NUM	CD	NumType=Card	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	4631	4631	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6482
# text = Site D (nt 4816 to 4851) specifically bound a ubiquitously expressed factor.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	_
2	D	d	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	nt	not	PART	RB	_	_	_	_	_
5	4816	4816	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	4851	4851	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	specifically	specifically	ADV	RB	_	_	_	_	_
10	bound	bound	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
13	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6483
# text = These results identify a transcriptional regulatory element associated with a nuclease-hypersensitive site in the pol gene of HIV-1 and suggest that its activity may be controlled by a complex interplay of cis-regulatory elements.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	nuclease	nuclease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
34	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	cis-regulatory	cis-regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6484
# text = Document 003001725 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001725	003001725	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6485
# text = Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6486
# text = Recent studies from our laboratory have indicated that protein tyrosine phosphatase (PTPase) inhibitors can down-modulate the tumor necrosis factor (TNF)-mediated activation of the nuclear transcription factor NF-kappa B in ML-1a, a monocytic cell line (Singh and Aggarwal, J. Biol.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B	b	PROPN	NNP	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	ML	Ml	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-1a	-1a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	line	line	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	Singh	Singh	PROPN	NNP	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	Aggarwal	Aggarwal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	J.	J.	PROPN	NNP	Number=Sing	_	_	_	_
53	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6487
# text = Chem. 1995: 270: 10631).
1	Chem.	Chem.	PROPN	NNP	Number=Sing	_	_	_	_
2	1995	1995	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_
4	270	270	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	10631	10631	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6488
# text = Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B, we examined the effect of PTPase inhibitors on the TNF-mediated induction of intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
8	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
33	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
38	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
47	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
48	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
58	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
63	1	1	NUM	CD	NumType=Card	_	_	_	_
64	and	and	CCONJ	CC	_	_	_	_	_
65	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
66	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
67	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
68	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
69	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
70	ELAM	ELAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
72	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
73	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
74	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6489
# text = Like ML-1a, human dermal microvessel endothelial cells (MVEC) treated with TNF rapidly activated (within 30 min) NF-kappa B; this effect was completely abolished by co-treatment with phenylarsine oxide (PAO), a specific inhibitor of PTPase.
1	Like	like	ADP	IN	_	_	_	_	_
2	ML	Ml	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-1a	-1a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	dermal	dermal	ADJ	JJ	Degree=Pos	_	_	_	_
7	microvessel	microvessel	NOUN	NN	Number=Sing	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	MVEC	MVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	treated	treat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	rapidly	rapidly	ADV	RB	_	_	_	_	_
17	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	within	within	ADP	IN	_	_	_	_	_
20	30	30	NUM	CD	NumType=Card	_	_	_	_
21	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	completely	completely	ADV	RB	_	_	_	_	_
32	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	co-treatment	co-treatment	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	phenylarsine	phenylarsine	NOUN	NN	Number=Sing	_	_	_	_
37	oxide	oxide	ADV	RB	_	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	PAO	pao	INTJ	UH	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
44	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6490
# text = The induction of ICAM-1, VCAM-1, and ELAM-1 by TNF in MVEC occurred within 6 h and was also completely down-regulated by PAO in a dose-dependent manner.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	ELAM	ELAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	MVEC	MVEC	PROPN	NNP	Number=Sing	_	_	_	_
19	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	h	h	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	completely	completely	ADV	RB	_	_	_	_	_
27	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6491
# text = PAO was found to be effective even when added 3 h after TNF, suggesting a rapid mode of action of this inhibitor.
1	PAO	pao	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
7	even	even	ADV	RB	_	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
18	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	action	action	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6492
# text = Besides PAO, other inhibitors of PTPase, including pervanadate and diamide, also blocked TNF-dependent NF-kappa B activation and induction of all the three adhesion proteins.
1	Besides	besides	ADP	IN	_	_	_	_	_
2	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
10	pervanadate	pervanadate	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	diamide	diamide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	all	all	DET	PDT	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	three	three	NUM	CD	NumType=Card	_	_	_	_
30	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6493
# text = Consistent with these results, the attachment of monocytes to MVEC was also blocked by the PTPase inhibitors.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	attachment	attachment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	MVEC	MVEC	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6494
# text = Thus, overall, our results demonstrate that a PTPase is involved either directly or indirectly in the pathway leading to the induction of endothelial cell adhesion molecules by TNF.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	overall	overall	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	directly	directly	ADV	RB	_	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	indirectly	indirectly	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
28	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6495
# text = Because of their role in cell adhesion, PTPase may provide a novel target of drug development for treatment of inflammation, atherogenesis, and tumor metastasis.
1	Because	because	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
14	target	target	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
17	development	development	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	atherogenesis	atherogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
27	metastasis	metastasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6496
# text = Document 003001730 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001730	003001730	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6497
# text = Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
12	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6498
# text = Co-stimulation of T-lymphocytes by T-cell receptor (TcR) occupancy and activation of the CD28 surface molecule results in enhanced proliferation and interleukin 2 (IL-2) production.
1	Co-stimulation	Co-stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6499
# text = The increase in IL-2 gene expression triggered by CD28 involves a kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
12	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6500
# text = B-like sequence in the 5'-regulatory region of the IL-2 promoter, called CD28-responsive element.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6501
# text = Stimulation of T-cells by agonistic anti-CD28 antibodies in conjunction with phorbol 12-myristate 13-acetate (PMA)- or TcR-derived signals induces the enhanced activation of the transcription factor NF-kappa B.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	agonistic	agonistic	ADJ	JJ	Degree=Pos	_	_	_	_
7	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
16	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	TcR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
28	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6502
# text = Here we report that CD28 engagement, however, exerts opposite effects on the transcription factor AP-1.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
6	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6503
# text = Whereas anti-CD28 together with PMA increased the DNA binding and trans-activation activity of NF-kappa B, PMA-induced activation of AP-1 was significantly suppressed.
1	Whereas	whereas	ADV	RB	_	_	_	_	_
2	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
3	together	together	ADV	RB	_	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	significantly	significantly	ADV	RB	_	_	_	_	_
31	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6504
# text = The inhibitory effect exerted by anti-CD28 was observed at the level of DNA binding as well as in functional reporter-gene assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	anti-CD28	anti-cd28	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6505
# text = These results suggest that the two transcription factors are independently regulated and may perform different functions during T-cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	independently	independently	ADV	RB	_	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	perform	perform	VERB	VB	VerbForm=Inf	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6506
# text = Document 003001731 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001731	003001731	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6507
# text = Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells.
1	Integrin-	Integrin-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	message	message	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6508
# text = A possible signaling role for the Syk tyrosine kinase.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
3	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	_
8	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6509
# text = Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction mediated by integrins.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	aspect	aspect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6510
# text = In the human monocytic cell line THP-1, either integrin-dependent cell adhesion to fibronectin or ligation of beta 1 integrins with antibodies causes a rapid and intense tyrosine phosphorylation of two sets of proteins of about 65-75 and 120-125 kDa.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
27	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	intense	intense	ADJ	JJ	Degree=Pos	_	_	_	_
32	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
33	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	two	two	NUM	CD	NumType=Card	_	_	_	_
36	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	about	about	ADP	IN	_	_	_	_	_
41	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	75	75	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	120	120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	125	125	NUM	CD	NumType=Card	_	_	_	_
48	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6511
# text = In addition, integrin ligation leads to nuclear translocation of the p50 and p65 subunits of the NF-kappa B transcription factor, to activation of a reporter gene driven by a promoter containing NF-kappa B sites, and to increased levels of mRNAs for immediate-early genes, including the cytokine interleukin (IL)-1 beta.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
5	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
6	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	nuclear	nuclear	VERB	VB	VerbForm=Inf	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
15	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
48	for	for	ADP	IN	_	_	_	_	_
49	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
52	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
57	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
62	1	1	NUM	CD	NumType=Card	_	_	_	_
63	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6512
# text = The tyrosine kinase inhibitors genistein and herbimycin A block both integrin-mediated tyrosine phosphorylation and increases in IL-1 beta message levels, indicating a causal relationship between the two events.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
5	genistein	genistein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	herbimycin	herbimycin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	block	block	NOUN	NN	Number=Sing	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	integrin-	integrin-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	message	message	NOUN	NN	Number=Sing	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	causal	causal	ADJ	JJ	Degree=Pos	_	_	_	_
28	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
29	between	between	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6513
# text = The components tyrosine phosphorylated subsequent to cell adhesion include paxillin, pp125FAK, and the SH2 domain containing tyrosine kinase Syk.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	components	component	NOUN	NNS	Number=Plur	_	_	_	_
3	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	paxillin	paxillin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	pp125FAK	pp125fak	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6514
# text = In contrast, integrin ligation with antibodies induces tyrosine phosphorylation of Syk but not of FAK or paxillin.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
5	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	tyrosine	tyrosine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	FAK	Fak	NUM	CD	NumType=Card	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	paxillin	paxillin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6515
# text = In adhering cells, pre-treatment with cytochalasin D suppresses tyrosine phosphorylation of FAK and paxillin but not of Syk, while IL-1 beta message induction is unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	adhering	adhere	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	pre-treatment	pre-treatment	ADJ	JJ	Degree=Pos	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	cytochalasin	cytochalasin	NOUN	NN	Number=Sing	_	_	_	_
8	D	d	NOUN	NN	Number=Sing	_	_	_	_
9	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	FAK	Fak	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	paxillin	paxillin	NOUN	NN	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	while	while	SCONJ	IN	_	_	_	_	_
22	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
26	message	message	NOUN	NN	Number=Sing	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6516
# text = These observations indicate that the Syk tyrosine kinase may be an important component of an integrin signaling pathway in monocytic cells, leading to activation of NF-kappa B and to increased levels of cytokine messages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	component	component	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
37	messages	message	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6517
# text = Document 003001735 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001735	003001735	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6518
# text = Induction of human immunodeficiency virus type 1 expression in monocytic cells by Cryptococcus neoformans and Candida albicans.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Cryptococcus	Cryptococcus	PROPN	NNP	Number=Sing	_	_	_	_
14	neoformans	neoformans	PROPN	NNPS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Candida	Candida	PROPN	NNP	Number=Sing	_	_	_	_
17	albicans	albicans	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6519
# text = Because candidiasis and cryptococcosis are common in human immunodeficiency virus (HIV)-infected persons, the effect of Cryptococcus neoformans and Candida albicans on HIV expression in monocytic cells was examined.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	candidiasis	candidiasis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	cryptococcosis	cryptococcosis	NOUN	NN	Number=Sing	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	persons	person	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Cryptococcus	Cryptococcus	PROPN	NNP	Number=Sing	_	_	_	_
22	neoformans	neoforman	PROPN	NNPS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Candida	Candida	PROPN	NNP	Number=Sing	_	_	_	_
25	albicans	albicans	PROPN	NNPS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6520
# text = Stimulation of the latently HIV-infected myelomonocytic cell line OM-10.1 with C.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	latently	latently	ADJ	JJ	Degree=Pos	_	_	_	_
5	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	OM	Om	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6521
# text = neoformans and C. albicans in the presence of pooled human serum caused a ratio-dependent increase in HIV production.
1	neoformans	neoforman	NOUN	NNS	Number=Plur	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
4	albicans	albicans	PROPN	NNPS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	pooled	pool	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6522
# text = Induction of HIV by C. neoformans was enhanced by anti-capsular antibody, while induction by both organisms was inhibited by anti-TNF-alpha antibody.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
6	neoformans	neoforman	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	anti-capsular	anti-capsular	ADJ	JJ	Degree=Pos	_	_	_	_
11	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	while	while	SCONJ	IN	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	anti-TNF	anti-TNF	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6523
# text = In THP-1 cells transfected with HIV plasmid constructs, both organisms induced transcription from the HIV long terminal repeat that was dependent on intact NF-kappaB binding sequences.
1	In	in	ADP	IN	_	_	_	_	_
2	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
9	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
10	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
19	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
20	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
21	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
27	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6524
# text = Thus, C. neoformans and C.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
4	neoformans	neoforman	PROPN	NNPS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6525
# text = albicans enhance HIV expression in monocytic cells through a TNF-alpha- and NF-kappaB-dependent mechanism.
1	albicans	albican	ADV	RB	_	_	_	_	_
2	enhance	enhance	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	HIV	Hiv	X	GW	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6526
# text = In HIV-infected patients, such enhancement may further impair host immunity and could accelerate the course of HIV disease.
1	In	in	ADP	IN	_	_	_	_	_
2	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	further	further	ADV	RB	_	_	_	_	_
10	impair	impair	ADJ	JJ	Degree=Pos	_	_	_	_
11	host	host	NOUN	NN	Number=Sing	_	_	_	_
12	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	accelerate	accelerate	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	course	course	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
20	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6527
# text = Document 003001739 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001739	003001739	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6528
# text = Sterol dependent LDL-receptor gene transcription in lymphocytes from normal and CML patients.
1	Sterol	Sterol	PROPN	NNP	Number=Sing	_	_	_	_
2	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	LDL	Ldl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CML	cml	ADJ	JJ	Degree=Pos	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6529
# text = Sterol regulatory element (SRE) has been recognized to regulate various key genes coding for especially low density lipoprotein (LDL)-receptor, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and HMG-CoA synthase known to play a crucial role in the cholesterol feedback mechanism.
1	Sterol	Sterol	PROPN	NNP	Number=Sing	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	especially	especially	ADV	RB	_	_	_	_	_
18	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
19	density	density	NOUN	NN	Number=Sing	_	_	_	_
20	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	3-	3-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	hydroxy	hydroxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	methylglutaryl	methylglutaryl	NOUN	NN	Number=Sing	_	_	_	_
33	coenzyme	coenzyme	NOUN	NN	Number=Sing	_	_	_	_
34	A	A	PROPN	NNP	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	CoA	CoA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	reductase	reductase	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	CoA	CoA	PROPN	NNP	Number=Sing	_	_	_	_
45	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
46	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	to	to	PART	TO	_	_	_	_	_
48	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
51	role	role	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	_
55	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
56	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6530
# text = The deranged cholesterol feedback mechanism has been widely recognised in initiation as well as progression of various types of cancers including chronic myeloid leukaemia (CML).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	deranged	derange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	_
4	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	widely	widely	ADV	RB	_	_	_	_	_
9	recognised	recognise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
23	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
24	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CML	CML	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6531
# text = Consequently, the present study was addressed to understand this phenomenon and revealed the existence of a unique 47 kDa protein factor having affinity for this SRE sequence in lymphocytes from normal subjects as well as its absence in lymphocytes from untreated CML patients.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	addressed	address	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
19	47	47	NUM	CD	NumType=Card	_	_	_	_
20	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
24	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	SRE	Sre	NOUN	NN	Number=Sing	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
33	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
34	as	as	ADV	RB	_	_	_	_	_
35	well	well	ADV	RB	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
43	CML	cml	NOUN	NN	Number=Sing	_	_	_	_
44	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6532
# text = However, this factor appeared when the CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	when	when	ADV	WRB	PronType=Int	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CML	CML	PROPN	NNP	Number=Sing	_	_	_	_
9	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
10	achieved	achieve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
12	haematological	haematological	ADJ	JJ	Degree=Pos	_	_	_	_
13	remission	remission	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CHR	CHR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
21	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6533
# text = Further, an inverse relationship was also observed between sterol modulated LDL-receptor gene transcription and the binding affinity of this 47 kDa factor to the SRE sequence.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inverse	inverse	ADJ	JJ	Degree=Pos	_	_	_	_
5	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	sterol	sterol	NOUN	NN	Number=Sing	_	_	_	_
11	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	LDL	LDL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	47	47	NUM	CD	NumType=Card	_	_	_	_
24	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	SRE	Sre	PROPN	NNP	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6534
# text = Based upon these results we propose that alpha-interferon through its receptor initiates phosphatidic acid dependent signalling which in turn regulates the affinity of 47 kDa sterol regulatory element binding factor as well as LDL-receptor gene transcription in lymphocytes from CML patients.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	upon	upon	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	phosphatidic	phosphatidic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
22	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	47	47	NUM	CD	NumType=Card	_	_	_	_
27	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
28	sterol	sterol	NOUN	NN	Number=Sing	_	_	_	_
29	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	as	as	ADV	RB	_	_	_	_	_
34	well	well	ADV	RB	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
43	from	from	ADP	IN	_	_	_	_	_
44	CML	CML	PROPN	NNP	Number=Sing	_	_	_	_
45	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6535
# text = Document 003001741 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001741	003001741	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6536
# text = Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg).
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	C3	C3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	desArg	desArg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6537
# text = The anaphylatoxin C3a has been reported to have immunomodulatory effects on a number of different cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	anaphylatoxin	anaphylatoxin	NOUN	NN	Number=Sing	_	_	_	_
3	C3	C3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	a	a	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
10	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6538
# text = In this study we investigated the effects of C3a and C3a(desArg) on gene expression and protein secretion of IL-6 in human PBMCs, either alone or in combination with LPS or IL-1beta.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	C3	C3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	desArg	desArg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	6	6	NUM	CD	NumType=Card	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	either	either	CCONJ	CC	_	_	_	_	_
31	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1beta	1beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6539
# text = C3a or C3a(desArg) alone exhibited no effect on the expression or secretion of IL-6.
1	C3	C3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	or	or	CCONJ	CC	_	_	_	_	_
4	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	desArg	desArg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	alone	alone	ADV	RB	_	_	_	_	_
9	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	no	no	DET	DT	_	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6540
# text = However, when PBMC were stimulated with LPS or IL-1beta, both C3a and C3a(desArg) were found to enhance IL-6 release by PBMC in a dose-dependent manner.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	C3	C3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	desArg	desArg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	release	release	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6541
# text = Since C3a has been shown to induce PGE2 production by monocytes, and PGE2 has been shown to influence cytokine production, we investigated the potential role of PGE2 in C3a-mediated enhancement of LPS- and IL-1beta-induced IL-6 production.
1	Since	since	ADP	IN	_	_	_	_	_
2	C3	C3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	a	a	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
9	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
22	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	C3	C3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1beta	1beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	6	6	NUM	CD	NumType=Card	_	_	_	_
48	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6542
# text = Indomethacin blocked PGE2 release, but had no influence on the observed effects of C3a, suggesting that the effects of C3a on IL-6 production are independent of PGE2 formation by monocytes.
1	Indomethacin	Indomethacin	PROPN	NNP	Number=Sing	_	_	_	_
2	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
4	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
13	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
32	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6543
# text = Northern blot analysis showed that C3a as well as C3a(desArg) enhanced LPS-induced mRNA levels for IL-6.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	C3	C3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	as	as	ADV	RB	_	_	_	_	_
9	well	well	ADV	RB	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	desArg	desArg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6544
# text = Pretreatment of PBMCs with pertussis toxin blocked the functions of C3a and C3a(desArg), indicating that the actions of these two molecules are mediated by a G protein-coupled pathway.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	pertussis	pertussis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
7	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	C3	C3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	desArg	desArg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	G	g	NOUN	NN	Number=Sing	_	_	_	_
32	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6545
# text = Furthermore, we investigated the effects of C3a and C3a(desArg) on induction of NF-kappaB and activating protein-1 binding.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	C3	C3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	desArg	desArg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6546
# text = Both molecules enhanced LPS-induced NF-kappaB and activating protein-1 binding activity.
1	Both	both	DET	DT	_	_	_	_	_
2	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
3	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6547
# text = These results demonstrate the capacity of intact C3a and its circulating des-Arg form to exert immunmodulatory effects in vitro.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
8	C3	C3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	a	a	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
12	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	circulating	circulat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	des	de	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Arg	Arg	ADJ	JJ	Degree=Pos	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
20	immunmodulatory	immunmodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6548
# text = Document 003001744 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001744	003001744	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6549
# text = Towards a molecular understanding of T-cell differentiation.
1	Towards	towards	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6550
# text = Lymphoid differentiation is one of the best studied examples of mammalian development.
1	Lymphoid	Lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
8	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	examples	example	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
12	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6551
# text = Here Hans Clevers and Michael Owen describe how the cloning of the genes that encode T-cell-specific membrane proteins allows the identification of transcription factors that control the expression of these T-cell genes.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	Hans	Hans	PROPN	NNPS	Number=Plur	_	_	_	_
3	Clevers	Clevers	PROPN	NNPS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Michael	Michael	PROPN	NNP	Number=Sing	_	_	_	_
6	Owen	Owen	PROPN	NNP	Number=Sing	_	_	_	_
7	describe	describe	VERB	VB	VerbForm=Inf	_	_	_	_
8	how	how	ADV	WRB	PronType=Int	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	encode	encode	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6552
# text = Such transcription factors play a key role in the development of the mature T-cell phenotype by functioning as 'master regulators of T-cell differentiation'.
1	Such	such	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	functioning	function	VERB	VBG	VerbForm=Ger	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
21	master	master	NOUN	NN	Number=Sing	_	_	_	_
22	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6553
# text = Document 003001755 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001755	003001755	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6554
# text = Identification of an ionomycin/cyclosporin A-responsive element within the human T cell receptor gamma enhancer.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
7	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6555
# text = Activation through the Ca2+/calcineurin pathway is essential to the transcription of many cytokine genes.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	+/	+/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6556
# text = The conserved cis-acting sequence, GGAAAA, and transcription factors binding to this sequence are involved in the response to increased intracellular Ca2+ concentrations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	GGAAAA	GGAAAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6557
# text = Here we report the identification and importance of the same sequence in a non-cytokine gene, the human T cell receptor gamma (TCRG) enhancer.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	non-cytokine	non-cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TCRG	TCRG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6558
# text = Results from site-directed mutations and electrophoretic mobility shift assays strongly suggest that this sequence mediates the ionomycin-induced activation of the TCRG enhancer.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
9	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
10	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
11	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ionomycin-	ionomycin-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	TCRG	TCRG	PROPN	NNP	Number=Sing	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6559
# text = Our studies provide an explanation for a previous observation that TCRG mRNA levels, but not mRNA levels for T cell receptor alpha and -beta, are increased by ionomycin treatment.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
9	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	TCRG	TCRG	VERB	VBG	VerbForm=Ger	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	mRNA	mRNa	ADJ	JJ	Degree=Pos	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	_
32	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6560
# text = Document 003001757 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001757	003001757	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6561
# text = Ex vivo activation of tumor-draining lymph node T cells reverses defects in signal transduction molecules.
1	Ex	ex	ADJ	JJ	Degree=Pos	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-draining	-drain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
8	node	node	NOUN	NN	Number=Sing	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	reverses	reverse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
15	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
16	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6562
# text = The adoptive transfer of tumor-draining lymph node (LN) T cells activated ex vivo with anti-CD3 and interleukin 2 (IL-2) mediates the regression of the poorly immunogenic murine melanoma D5.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adoptive	adoptive	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	draining	draining	VERB	VBG	VerbForm=Ger	_	_	_	_
8	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
9	node	node	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LN	LN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	ex	ex	NUM	CD	NumType=Card	_	_	_	_
17	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regression	regression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	poorly	poorly	ADJ	JJ	Degree=Pos	_	_	_	_
34	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
35	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
36	melanoma	melanoma	NOUN	NN	Number=Sing	_	_	_	_
37	D5	d5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6563
# text = The efficacy of the activated LN cells is augmented when the sensitizing tumor is a genetically modified variant (designated D5G6) that secretes granulocyte/macrophage-colony-stimulating factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LN	Ln	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	sensitizing	sensitizing	NOUN	NN	Number=Sing	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	genetically	genetically	ADV	RB	_	_	_	_	_
17	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	D5G6	D5G6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	secretes	secrete	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-stimulating	-stimulating	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6564
# text = In contrast to anti-CD3/IL-2-activated LN cells, adoptive transfer of freshly isolated tumor-draining LN T cells has no therapeutic activity.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	anti-CD3/IL	anti-CD3/IL	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-activated	-activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	LN	Ln	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	adoptive	adoptive	ADJ	JJ	Degree=Pos	_	_	_	_
12	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	freshly	freshly	ADV	RB	_	_	_	_	_
15	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	draining	draining	VERB	VBG	VerbForm=Ger	_	_	_	_
19	LN	Ln	PROPN	NNP	Number=Sing	_	_	_	_
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	no	no	DET	DT	_	_	_	_	_
24	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6565
# text = To determine whether the acquisition of antitumor function during ex vivo activation is associated with modifications in signal transduction capacity, the protein tyrosine kinases p56lck and p59fyn and proteins of the NF-kappaB family were analyzed in tumor-draining LN T cells.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	acquisition	acquisition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	antitumor	antitumor	NOUN	NN	Number=Sing	_	_	_	_
8	function	function	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	ex	ex	NOUN	NN	Number=Sing	_	_	_	_
11	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
20	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
25	kinases	kinase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	p56lck	p56lck	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p59fyn	p59fyn	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
36	family	family	NOUN	NN	Number=Sing	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	draining	drain	VERB	VBG	VerbForm=Ger	_	_	_	_
43	LN	Ln	PROPN	NNP	Number=Sing	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6566
# text = The levels of p56lck and p59fyn were lower in tumor-draining than in normal LN T cells and production of tyrosine-phosphorylated substrates was markedly depressed following anti-CD3 stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p56lck	p56lck	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p59fyn	p59fyn	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	draining	drain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	than	than	ADP	IN	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	LN	LN	PROPN	NNP	Number=Sing	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	markedly	markedly	ADV	RB	_	_	_	_	_
28	depressed	depress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
30	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6567
# text = After 5-day anti-CD3/IL-2 activation, levels of p56lck and p59fyn and protein tyrosine kinase activity increased.
1	After	after	ADP	IN	_	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	day	day	NOUN	NN	Number=Sing	_	_	_	_
5	anti-CD3/IL	anti-cd3/il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	p56lck	p56lck	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	p59fyn	p59fyn	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6568
# text = Interestingly, the levels of p56lck, p59fyn, and tyrosine kinase activity were higher in activated T cells derived from LN that drained D5G6 than they were in those from D5 tumors.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p59fyn	p59fyn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	LN	LN	PROPN	NNP	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	drained	drain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	D5G6	D5G6	NUM	CD	NumType=Card	_	_	_	_
27	than	than	SCONJ	IN	_	_	_	_	_
28	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	D5	D5	NUM	CD	NumType=Card	_	_	_	_
34	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6569
# text = In contrast, the cytoplasmic levels of c-Rel and Rel
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6570
# text = A were normal in freshly isolated tumor-draining LN, as was nuclear kappaB DNA-binding activity induced by anti-CD3 mAb or phorbol myristate acetate.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	freshly	freshly	ADV	RB	_	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	draining	draining	NOUN	NN	Number=Sing	_	_	_	_
10	LN	Ln	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
23	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
26	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
27	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6571
# text = Stimulation of activated LN cells with D5 tumor cells induced the nuclear translocation of NF-kappaB.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	LN	Ln	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	D5	d5	NUM	CD	NumType=Card	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6572
# text = These findings indicate that the recovery of proteins mediating signal transduction through the T cell receptor/CD3 complex in LN T cells activated ex vivo was associated with the acquisition of antitumor function.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	recovery	recovery	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	receptor/	receptor/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	LN	LN	PROPN	NNP	Number=Sing	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	ex	ex	NUM	CD	NumType=Card	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	acquisition	acquisition	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	antitumor	antitumor	NOUN	NN	Number=Sing	_	_	_	_
33	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6573
# text = Document 003001758 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001758	003001758	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6574
# text = NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A, protein kinase C, and Ca(2+)-regulated kinases.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	line	line	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6575
# text = NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus (HIV) genes.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	number	number	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6576
# text = In T cells, NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha (TNF alpha).
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6577
# text = In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line (Jurkat) and its subclone JCT6, which presents a deficiency in the PKA transduction pathway.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
10	events	event	NOUN	NNS	Number=Plur	_	_	_	_
11	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	ADV	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
33	JCT6	Jct6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	presents	present	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	_
42	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6578
# text = We found that in both cell lines, both phorbol ester and TNF alpha were able to activate NF-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6579
# text = Phorbol activation was positively modulated by Ca2+ influx while TNF alpha activation was not.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	positively	positively	ADV	RB	_	_	_	_	_
5	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	influx	influx	NUM	CD	NumType=Card	_	_	_	_
10	while	while	SCONJ	IN	_	_	_	_	_
11	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6580
# text = Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin, the TNF alpha effect was unchanged.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
11	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
12	staurosporin	staurosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	unchanged	unchange	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6581
# text = TNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators.
1	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
2	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
6	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
16	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6582
# text = Moreover, cAMP activators did not activate NF-kappa B in Jurkat cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
4	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6583
# text = Thus, TNF alpha-induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C (PKC), protein kinase A, or Ca(2+)-regulated kinases.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	none	none	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	C	C	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
36	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6584
# text = Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC, by a mechanism that increases NF-kappa B/I kappa B dissociation without affecting the NF-kappa B translocation step.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acidification	acidification	NOUN	NN	Number=Sing	_	_	_	_
8	facilitated	facilitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B/	Bith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
34	without	without	SCONJ	IN	_	_	_	_	_
35	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
42	step	step	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6585
# text = Document 003001760 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001760	003001760	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6586
# text = Abnormal apoptosis and cell cycle progression in humans exposed to methyl tertiary-butyl ether and benzene contaminating water.
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
6	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
9	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	methyl	methyl	VERB	VB	VerbForm=Inf	_	_	_	_
12	tertiary	tertiary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	butyl	butyl	NOUN	NN	Number=Sing	_	_	_	_
15	ether	ether	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	benzene	benzene	NOUN	NN	Number=Sing	_	_	_	_
18	contaminating	contaminate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	water	water	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6587
# text = 1. In this study we hypothesized that in individuals with certain genetic makeup, MTBE, benzene or their metabolites act as adducts and may induce programmed cell death.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
13	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
14	makeup	makeup	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	MTBE	Mtbe	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	benzene	benzene	PRON	PRP	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	metabolites	metabolite	NOUN	NN	Number=Sing	_	_	_	_
22	act	act	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	adducts	adduct	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6588
# text = 2. Our study involved a group of 60 male and female subjects who were exposed to MTBE and benzene-contaminated water concentrations up to 76 PPB for MTBE and 14 PPB for benzene, for a period of 5 to 8 years.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	group	group	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	60	60	NUM	CD	NumType=Card	_	_	_	_
10	male	male	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
13	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
14	who	who	PRON	WP	PronType=Rel	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	MTBE	Mtbe	VERB	VB	VerbForm=Inf	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	benzene	benzene	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	contaminated	contaminate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	water	water	NOUN	NN	Number=Sing	_	_	_	_
24	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
25	up	up	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	76	76	NUM	CD	NumType=Card	_	_	_	_
28	PPB	Ppb	PROPN	NNP	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	MTBE	MTBE	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	14	14	NUM	CD	NumType=Card	_	_	_	_
33	PPB	Ppb	PROPN	NNP	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	benzene	benzene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	period	period	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	5	5	NUM	CD	NumType=Card	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	8	8	NUM	CD	NumType=Card	_	_	_	_
44	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6589
# text = For comparison, we recruited a control group consisting of 32 healthy males and females with similar age distribution and without a history of exposure to MTBE or benzene.
1	For	for	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	recruited	recruit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	group	group	NOUN	NN	Number=Sing	_	_	_	_
9	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	32	32	NUM	CD	NumType=Card	_	_	_	_
12	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
13	males	male	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	females	female	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
18	age	age	NOUN	NN	Number=Sing	_	_	_	_
19	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	without	without	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	history	history	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	MTBE	MTBE	PROPN	NNP	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	benzene	benzene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6590
# text = 3.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6591
# text = Peripheral blood lymphocytes (PBL) of both groups were tested for the percentage of apoptotic cells and cell cycle progression using flow cytometry.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	PBL	PBL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
20	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
21	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
24	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6592
# text = 4. When apoptotic lymphocytes from exposed individuals were compared to apoptotic lymphocytes from the control group, statistically-significant differences between each mean group were detected (26.4 +/- 1.8 and 12.1 +/- 1.3, respectively), indicating an increased rate of apoptosis in 80.5% of exposed individuals (P < 0.0001, Mann-Whitney U-Test).
1	4	4	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	When	when	ADV	WRB	PronType=Int	_	_	_	_
4	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	exposed	exposed	ADJ	JJ	Degree=Pos	_	_	_	_
8	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	statistically	statistically	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	each	each	DET	DT	_	_	_	_	_
25	mean	mean	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	26.4	26.4	NUM	CD	NumType=Card	_	_	_	_
31	+/-	+/-	SYM	SYM	_	_	_	_	_
32	1.8	1.8	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	12.1	12.1	NUM	CD	NumType=Card	_	_	_	_
35	+/-	+/-	SYM	SYM	_	_	_	_	_
36	1.3	1.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	80.5	80.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	%	%	SYM	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	P	p	NOUN	NN	Number=Sing	_	_	_	_
55	<	<	PUNCT	-LRB-	_	_	_	_	_
56	0.0001	0.0001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	Mann	Mann	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	Whitney	Whitney	PROPN	NNP	Number=Sing	_	_	_	_
61	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	Test	Test	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6593
# text = MTBE and benzene-induced apoptosis is attributed to a discrete block within the cell cycle progression.
1	MTBE	Mtbe	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	benzene	benzene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
12	block	block	NOUN	NN	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
17	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6594
# text = Because cell cycle analysis showed that in PBL from chemically-exposed individuals, between 20-50% of cells were accumulated at the S-G2/M boundaries.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	chemically	chemically	ADV	RB	_	_	_	_	SpaceAfter=No
11	-exposed	-expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	S-	s-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	G2/	G2/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	M	m	NOUN	NN	Number=Sing	_	_	_	_
28	boundaries	boundary	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6595
# text = 5. One of the signaling molecules which mediates programmed cell death is nuclear factor Kappa-B (NF-kappa B).
1	5	5	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	One	one	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	death	death	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	Kappa	Kappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6596
# text = NF-kappa B was examined as one of the many molecular mechanisms for mediating cell death by MTBE and benzene.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
4	B	b	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	SCONJ	IN	_	_	_	_	_
15	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	death	death	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	MTBE	Mtbe	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	benzene	benzene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6597
# text = Indeed, addition of inhibitors of NF-kappa B activation pyrrolidine dithiocarbamate (PDTC), to the lymphocytes of the chemically-exposed group was capable of inhibiting programmed cell death by 40%.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
13	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	chemically	chemically	ADV	RB	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
29	of	of	SCONJ	IN	_	_	_	_	_
30	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
31	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	death	death	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6598
# text = This reversal of apoptosis almost to the control level by inhibitor of NF-kappa B activation may indicate involvement of this signaling molecule in MTBE and benzene induction of programmed cell death.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	reversal	reversal	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	almost	almost	ADV	RB	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	indicate	indicate	VERB	VB	VerbForm=Inf	_	_	_	_
20	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	MTBE	MTBE	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	benzene	benzene	NOUN	NN	Number=Sing	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6599
# text = Document 003001767 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001767	003001767	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6600
# text = Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes.
1	Role	role	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	EGR1	EGR1	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	CD44	Cd44	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6601
# text = The immediate-early gene egr-1 encodes a transcription factor (EGR1) that links B-cell antigen receptor (BCR) signals to downstream activation events through the regulation of previously unidentified target genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	encodes	encode	NOUN	NNS	Number=Plur	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	EGR1	EGR1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	links	link	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	BCR	BCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	events	event	NOUN	NNS	Number=Plur	_	_	_	_
31	through	through	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	previously	previously	ADV	RB	_	_	_	_	_
36	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
37	target	target	NOUN	NN	Number=Sing	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6602
# text = Here we identify the gene encoding the lymphocyte homing and migration protein CD44 as a target of EGR1 regulation in B cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
9	homing	homing	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	CD44	CD44	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	target	target	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	EGR1	EGR1	NUM	CD	NumType=Card	_	_	_	_
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6603
# text = BCR-induced increases in CD44 mRNA expression and transcription levels are shown to occur in EGR1-expressing but not in nonexpressing subclones of the B-cell line WEHI-231.
1	BCR	Bcr	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	CD44	CD44	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	EGR1	EGR1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	nonexpressing	nonexpresse	ADJ	JJ	Degree=Pos	_	_	_	_
24	subclones	subclone	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	line	line	NOUN	NN	Number=Sing	_	_	_	_
31	WEHI	Wehi	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	231	231	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6604
# text = Kinetics of egr-1 transcription and the appearance of nuclear EGR1 protein precede CD44 induction and occur within 30 min after stimulation in the EGR1-expressing subclone.
1	Kinetics	Kinetic	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	EGR1	EGR1	NUM	CD	NumType=Card	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	precede	precede	NOUN	NN	Number=Sing	_	_	_	_
14	CD44	Cd44	NUM	CD	NumType=Card	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	30	30	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	EGR1	Egr1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	expressing	expressing	ADJ	JJ	Degree=Pos	_	_	_	_
28	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6605
# text = A single EGR1 binding motif is demonstrated at bp -301 of the human CD44 promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
3	EGR1	Egr1	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	301	301	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	CD44	Cd44	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6606
# text = Cotransfection of a CD44 promoter-chloramphenicol acetyltransferase reporter construct with an egr-1 expression vector resulted in a 6.5- to 8.5-fold induction of transcriptional activity relative to an empty expression vector.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	CD44	CD44	NUM	CD	NumType=Card	_	_	_	_
5	promoter-chloramphenicol	promoter-chloramphenicol	ADJ	JJ	Degree=Pos	_	_	_	_
6	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
16	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	6.5	6.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	8.5	8.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	relative	relative	ADV	RB	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	empty	empty	ADJ	JJ	Degree=Pos	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6607
# text = The EGR1 binding motif was shown to be necessary for stimulus-induced expression of a CD44 promoter-chloramphenicol acetyltransferase reporter construct in nontransformed B lymphocytes and was required for transactivation by an EGR1 expression vector in a B-cell line.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	EGR1	EGR1	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	stimulus	stimulus	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	CD44	CD44	PROPN	NNP	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
21	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
22	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
23	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	nontransformed	nontransformed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	EGR1	EGR1	NUM	CD	NumType=Card	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6608
# text = These studies identify EGR1 as an intermediary linking BCR-derived signals to the induction of CD44.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	EGR1	EGR1	NUM	CD	NumType=Card	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	intermediary	intermediary	ADJ	JJ	Degree=Pos	_	_	_	_
8	linking	link	NOUN	NN	Number=Sing	_	_	_	_
9	BCR	BCR	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CD44	CD44	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6609
# text = The relevance of these molecular events to BCR signal transduction and antigen-stimulated B-cell-mediated immune responses is discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	events	event	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	BCR	Bcr	VERB	VB	VerbForm=Inf	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	antigen-	antigen-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	immune	immune	PRON	PRP	_	_	_	_	_
19	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6610
# text = Document 003001772 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001772	003001772	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6611
# text = Differential monocyte adhesion and adhesion molecule expression in venous and arterial endothelial cells.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
3	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	venous	venous	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	arterial	arterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6612
# text = We compared U-937 cell adhesion and adhesion molecule expression in human umbilical venous (HUVECs) and arterial (HUAECs) endothelial cells exposed to tumor necrosis factor (TNF), interleukin-1, and lipopolysaccharide (LPS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	937	937	NUM	CD	NumType=Card	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
15	venous	venous	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	arterial	arterial	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HUAECs	Huaecs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6613
# text = TNF and LPS stimulated vascular cell adhesion molecule (VCAM)-1 surface expression and adhesion of U-937 monocyte-like cells to HUVECs but not to HUAECs.
1	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
4	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	937	937	NUM	CD	NumType=Card	_	_	_	_
22	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	HUVECs	HUVEC	PROPN	NNPS	Number=Plur	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	HUAECs	Huaecs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6614
# text = Antibody studies demonstrated that in HUVECs at least 75% of the adhesion response is VCAM-1 mediated.
1	Antibody	Antibody	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	HUVECs	Huvecs	PROPN	NNPS	Number=Plur	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6615
# text = Interleukin-1 stimulated U-937 cell adhesion to and VCAM-1 surface expression in both HUVECs and HUAECs.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	937	937	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	VCAM	VCAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	HUAECs	HUAEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6616
# text = Pyrrolidinedithiocarbamate and the proteasome inhibitor MG-132 blocked TNF- and LPS-stimulated U-937 cell adhesion to HUVECs.
1	Pyrrolidinedithiocarbamate	Pyrrolidinedithiocarbamate	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
6	MG	Mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	132	132	NUM	CD	NumType=Card	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	937	937	NUM	CD	NumType=Card	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6617
# text = These agents also significantly decreased TNF- and LPS-stimulated increases in HUVEC surface VCAM-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	HUVEC	Huvec	PROPN	NNP	Number=Sing	_	_	_	_
15	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
16	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6618
# text = TNF increased VCAM-1 protein and mRNA in HUVECs that was blocked by pyrrolidinedithiocarbamate.
1	TNF	TNF	AUX	VB	VerbForm=Inf	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	VCAM	VCAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6619
# text = However, neither TNF or LPS stimulated VCAM-1 expression in HUAECs.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	neither	neither	CCONJ	CC	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	HUAECs	HUAEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6620
# text = TNF stimulated expression of both intercellular adhesion molecule-1 and E-selectin in HUVECs, but in HUAECs, only intercellular adhesion molecule-1 was increased.
1	TNF	Tnf	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	HUAECs	Huaecs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6621
# text = Electrophoretic mobility shift assays demonstrated no difference in the pattern of TNF-stimulated nuclear factor-kappaB activation between HUVECs and HUAECs.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	between	between	ADP	IN	_	_	_	_	_
21	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	HUAECs	HUAEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6622
# text = These studies demonstrate a novel and striking insensitivity of arterial endothelium to the effects of TNF and LPS and indicate a dissociation between the ability of HUAECs to upregulate nuclear factor-kappaB and VCAM-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
8	insensitivity	insensitivity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	arterial	arterial	ADJ	JJ	Degree=Pos	_	_	_	_
11	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	indicate	indicate	VERB	VB	VerbForm=Inf	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HUAECs	HUAEC	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	upregulate	upregulate	VERB	VB	VerbForm=Inf	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6623
# text = Document 003001780 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001780	003001780	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6624
# text = Surfactant suppresses NF-kappa B activation in human monocytic cells.
1	Surfactant	Surfactant	PROPN	NNP	Number=Sing	_	_	_	_
2	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6625
# text = In addition to biophysical properties, pulmonary surfactant has immunomodulatory activity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	biophysical	biophysical	ADJ	JJ	Degree=Pos	_	_	_	_
5	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	pulmonary	pulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
8	surfactant	surfactant	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6626
# text = We previously demonstrated that both synthetic (Exosurf) and modified natural surfactant (Survanta) downregulated endotoxin-stimulated inflammatory cytokine mRNA levels and protein products (tumor necrosis factor-alpha [TNF], interleukin-1-beta [IL-1], interleukin-6 [IL-6]) in human alveolar macrophages.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	synthetic	synthetic	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Exosurf	Exosurf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	modified	modify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
13	surfactant	surfactant	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Survanta	Survanta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	downregulated	downregulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	endotoxin-	endotoxin-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	products	product	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
42	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	interleukin	interleukin	ADV	RB	_	_	_	_	SpaceAfter=No
49	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	6	6	NUM	CD	NumType=Card	_	_	_	_
51	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	in	in	ADP	IN	_	_	_	_	_
58	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
59	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
60	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6627
# text = In this study, we report that both Exosurf and Survanta suppress TNF mRNA and secretion (85 +/- 4% mean percent inhibition +/- SEM by Exosurf; 71 +/- 6% by Survanta) by endotoxin-stimulated THP-1, a human monocytic cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	Exosurf	Exosurf	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Survanta	Survanta	PROPN	NNP	Number=Sing	_	_	_	_
12	suppress	suppress	PROPN	NNP	Number=Sing	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	85	85	NUM	CD	NumType=Card	_	_	_	_
19	+/-	+/-	SYM	SYM	_	_	_	_	_
20	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	mean	mean	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	percent	percent	ADJ	JJ	Degree=Pos	_	_	_	_
24	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
25	+/-	+/-	SYM	NFP	_	_	_	_	_
26	SEM	SEM	PROPN	NNP	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	Exosurf	Exosurf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	;	;	PUNCT	,	_	_	_	_	_
30	71	71	NUM	CD	NumType=Card	_	_	_	_
31	+/-	+/-	SYM	SYM	_	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	Survanta	Survanta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	endotoxin-	endotoxin-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6628
# text = Because surfactant downregulated inflammatory cytokine production similarly in both normal human alveolar macrophages and the THP-1 cell line, we used this cell line to investigate whether surfactant affected transcriptional mechanisms.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	surfactant	surfactant	ADV	RB	_	_	_	_	_
3	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	similarly	similarly	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
29	whether	whether	SCONJ	IN	_	_	_	_	_
30	surfactant	surfactant	ADV	RB	_	_	_	_	_
31	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6629
# text = Specifically, we examined nuclear factor-kappa B (NF-kappa B) activation because it is crucial in transcriptional regulation of many inflammatory cytokine genes including TNF, IL-1, and IL-6.
1	Specifically	specifically	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	because	because	SCONJ	IN	_	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
29	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6630
# text = Electrophoretic mobility shift assays showed that both surfactants decreased activation of NF-kappa B.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	surfactants	surfactant	NOUN	NNS	Number=Plur	_	_	_	_
9	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6631
# text = The presence of both p65 and p50 NF-kappa B components in LPS-activated THP-1 cells was confirmed by specific antibody induction of supershifts in mobility assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	p65	p65	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p50	p50	NUM	CD	NumType=Card	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	components	component	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	supershifts	supershift	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
31	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6632
# text = These results are the first to suggest that surfactant's suppressive effects on inflammatory cytokine production may involve transcriptional regulation through inhibition of NF-kappa B activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	surfactant	surfactant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	's	's	PART	POS	_	_	_	_	_
11	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6633
# text = Document 003001782 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001782	003001782	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6634
# text = The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	ADP	IN	_	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6635
# text = The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region was fused to the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF producing cell lines, the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	1311	1311	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	base	base	NOUN	NN	Number=Sing	_	_	_	_
5	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
14	promoter	promoter	X	GW	_	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Luc	Luc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	studied	studie	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
31	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
32	system	system	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	three	three	NUM	CD	NumType=Card	_	_	_	_
35	TNF	Tnf	SCONJ	IN	_	_	_	_	_
36	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
42	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	MLA	MLA	PROPN	NNP	Number=Sing	_	_	_	_
48	144	144	NUM	CD	NumType=Card	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	729-6	729-6	NUM	CD	NumType=Card	_	_	_	_
56	B	b	NOUN	NN	Number=Sing	_	_	_	_
57	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
58	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6636
# text = This full length promoter construct can be induced by phorbol 13-myristate acetate (PMA) in each of these cell types.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
3	length	length	NOUN	NN	Number=Sing	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
14	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	each	each	DET	DT	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6637
# text = Analysis of a series of 5'-truncations showed several peaks of basal and PMA induced activity suggesting the presence of several positive and negative regulatory elements.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	series	series	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	truncations	truncation	NOUN	NNS	Number=Plur	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	peaks	peak	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6638
# text = A PMA responsive element was localized to a region between -95 and -36 bp relative to the transcription start site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
3	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	-95	-95	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	36	36	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	relative	relative	ADV	RB	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	start	start	NOUN	NN	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6639
# text = Within this region, single AP-2- and AP-1- like consensus sequences were noted.
1	Within	within	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	_
15	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
16	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
17	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6640
# text = These AP-2 and AP-1 sites were each modified with a double point mutation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	each	each	DET	DT	_	_	_	_	_
12	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	double	double	ADJ	JJ	Degree=Pos	_	_	_	_
16	point	point	NOUN	NN	Number=Sing	_	_	_	_
17	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6641
# text = A modest (20-50%) reduction in TNF promoter activity was observed with the AP-2 site mutation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	modest	modest	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6642
# text = However, mutation of the AP-1 site markedly diminished both the basal and PMA-activated promoter activity.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	markedly	markedly	ADV	RB	_	_	_	_	_
11	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6643
# text = Also co-transfections of the wild-type promoter construct with an AP-1/c-jun expression vector resulted in augmented basal and PMA-induced promoter activity.
1	Also	also	ADV	RB	_	_	_	_	_
2	co-transfections	co-transfection	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1/	1ith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
20	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	augmented	augmented	ADJ	JJ	Degree=Pos	_	_	_	_
23	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6644
# text = Document 003001787 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001787	003001787	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6645
# text = Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
3	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	bare	bear	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
10	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
14	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	RFX5	RFX5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6646
# text = Two of the genes defective in the five complementation groups identified in the class II-negative bare lymphocyte syndrome or corresponding laboratory mutants have been cloned.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	five	five	NUM	CD	NumType=Card	_	_	_	_
9	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
10	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	bare	bare	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
20	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	corresponding	corresponding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
24	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6647
# text = One gene encodes a protein, RFX5, that is a member of the RFX family of DNA binding proteins.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	RFX5	RFX5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	member	member	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	RFX	RFX	PROPN	NNP	Number=Sing	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6648
# text = The other, CIITA, encodes a large protein with a defined acidic transcriptional activation domain; this protein does not interact with DNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6649
# text = Expression plasmids encoding regions of RFX5 fused to the GAL4 DNA binding domain activated transcription from a reporter construct containing GAL4 sites in a cotransfection assay in the Raji human B cell line.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
3	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	RFX5	RFX5	PROPN	NNP	Number=Sing	_	_	_	_
7	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GAL4	GAL4	PROPN	NNP	Number=Sing	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	GAL4	GAL4	NUM	CD	NumType=Card	_	_	_	_
22	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6650
# text = However, these plasmids produced transcriptional activity in HeLa cells only in conjunction with interferon gamma stimulation, a condition in which expression of both CIITA and class II major histocompatibility complex surface proteins are induced.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
5	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	condition	condition	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	class	class	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
31	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
32	complex	complex	SYM	SYM	_	_	_	_	_
33	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6651
# text = Furthermore, these plasmids were not active in RJ2.2.5, an in vitro mutagenized derivative of Raji in which both copies of CIITA are defective.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	RJ	RJ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	2.2.5	2.2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
15	mutagenized	mutagenized	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6652
# text = Transcriptional activation by the RFX5 fusion protein could be restored in RJ2.2.5 by cotransfection with a CIITA expression plasmid.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	RFX5	RFX5	PROPN	NNP	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	restored	restore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	RJ2.2.5	RJ2.2.5	NUM	CD	NumType=Card	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6653
# text = Finally, a direct interaction between RFX5 and CIITA was detected with the yeast two-hybrid and far-Western blot assays.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	RFX5	RFX5	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	far	far	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
22	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
23	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6654
# text = Thus, RFX5 can activate transcription only in cooperation with CIITA.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	RFX5	RFX5	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6655
# text = RFX5 and CIITA associate to form a complex capable of activating transcription from class II major histocompatibility complex promoters.
1	RFX5	RFX5	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
4	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6656
# text = In this complex, promoter specificity is determined by the DNA binding domain of RFX5 and the general transcription apparatus is recruited by the acidic activation domain of CIITA.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	RFX5	RFX5	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	apparatus	apparatus	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6657
# text = Document 003001792 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001792	003001792	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6658
# text = Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.
1	Redox	Redox	NOUN	NN	Number=Sing	_	_	_	_
2	status	status	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	influences	influence	NOUN	NNS	Number=Plur	_	_	_	_
6	constitutive	constitutive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	HIV	haHive	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	long	long	ADV	RB	Degree=Pos	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	repeat	repeat	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6659
# text = We have tested the hypothesis that cellular activation events occurring in T lymphocytes and monocytes and mediated through translocation of the transcription factor NF-kappa B are dependent upon the constitutive redox status of these cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	upon	upon	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
33	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
34	status	status	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6660
# text = We used phenolic, lipid-soluble, chain-breaking antioxidants (butylated hydroxyanisole (BHA), nordihydroquairetic acid, or alpha-tocopherol (vitamin E) to show that peroxyl radical scavenging in unstimulated and PMA- or TNF-stimulated cells blocks the functions depending on NF-kappa B activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	phenolic	phenolic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	lipid	lipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	soluble	soluble	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	breaking	breaking	NOUN	NN	Number=Sing	_	_	_	_
12	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	butylated	butylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	hydroxyanisole	hydroxyanisole	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	BHA	BHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	nordihydroquairetic	nordihydroquairetic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
29	E	e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
33	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	peroxyl	peroxyl	NOUN	NN	Number=Sing	_	_	_	_
35	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
36	scavenging	scavenging	VERB	VBG	VerbForm=Ger	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
47	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
50	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
51	on	on	ADP	IN	_	_	_	_	_
52	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
55	B	b	NOUN	NN	Number=Sing	_	_	_	_
56	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6661
# text = BHA was found to suppress not only PMA- or TNF-induced, but also constitutive, HIV-enhancer activity concomitant to an inhibition of NF-kappa B binding activity in both lymphoblastoid T (J.Jhan) and monocytic (U937) cell lines.
1	BHA	BHa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
6	not	not	ADV	RB	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	concomitant	concomitant	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	both	both	DET	DT	_	_	_	_	_
36	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
37	T	T	PROPN	NNP	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	J.Jhan	J.Jhan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	monocytic	monocytic	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6662
# text = This was also true for KBF (p50 homodimer) binding activity in U937 cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	KBF	KBF	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p50	p50	NUM	CD	NumType=Card	_	_	_	_
9	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6663
# text = Secretion of TNF, the product of another NF-kappa B-dependent gene, was abolished by BHA in PMA-stimulated U937 cells.
1	Secretion	Secretion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	product	product	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	another	another	DET	DT	_	_	_	_	_
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	BHA	BHA	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	U937	U937	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6664
# text = The anti-oxidative effect of BHA was accompanied by an increase in thiol, but not glutathione, content in stimulated and unstimulated T cell, whereas TNF stimulation itself barely modified the cellular thiol level.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	anti-oxidative	anti-oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	BHA	BHA	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	glutathione	glutathione	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	content	content	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	unstimulated	unstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
30	barely	barely	ADV	RB	_	_	_	_	_
31	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
34	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	_
35	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6665
# text = Oxidative stress obtained by the addition of H2O2 to the culture medium of J.Jhan or U937 cells could not by itself induce NF-kappa B activation.
1	Oxidative	Oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
2	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
3	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
12	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	J.Jhan	J.Jhan	PROPN	NNP	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	U937	U937	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
22	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6666
# text = These observations suggest that TNF and PMA do not lead to NF-kappa B activation through induction of changes in the cell redox status.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
8	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
25	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6667
# text = Rather, TNF and PMA can exert their effect only if cells are in an appropriate redox status, because prior modification toward reduction with BHA treatment prevents this activation.
1	Rather	Rather	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
8	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	if	if	SCONJ	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
17	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
18	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	because	because	SCONJ	IN	_	_	_	_	_
21	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
22	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
23	toward	toward	ADP	IN	_	_	_	_	_
24	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	BHA	BHA	PROPN	NNP	Number=Sing	_	_	_	_
27	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
28	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6668
# text = It appears that a basal redox equilibrium tending toward oxidation is a prerequisite for full activation of transduction pathways regulating the activity of NF-kappa B-dependent genes.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
6	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
7	equilibrium	equilibrium	NOUN	NN	Number=Sing	_	_	_	_
8	tending	tend	VERB	VBG	VerbForm=Ger	_	_	_	_
9	toward	toward	ADP	IN	_	_	_	_	_
10	oxidation	oxidation	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	prerequisite	prerequisite	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
20	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6669
# text = Document 003001795 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001795	003001795	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6670
# text = Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation:
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	freshly	freshly	ADV	RB	_	_	_	_	_
8	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 6671
# text = a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages.
1	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6672
# text = Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	replicates	replicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	more	more	ADV	RBR	_	_	_	_	_
13	efficiently	efficiently	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	differentiated	differentiated	ADJ	JJ	Degree=Pos	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	freshly	freshly	ADV	RB	_	_	_	_	_
22	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6673
# text = We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	partly	partly	ADV	RB	_	_	_	_	_
8	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6674
# text = We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	changed	change	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MDMs	MDM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	alveolar	alveolar	VERB	VB	VerbForm=Inf	_	_	_	_
34	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	AMs	am	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6675
# text = Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers.
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
10	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
11	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
12	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	time	time	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	favor	favor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
30	RelB	RelB	NOUN	NN	Number=Sing	_	_	_	_
31	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6676
# text = As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels.
1	As	as	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	MDMs	Mdms	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	AMs	AMs	PROPN	NNPS	Number=Plur	_	_	_	_
6	constitutively	constitutively	ADV	RB	_	_	_	_	_
7	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
13	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
14	although	although	SCONJ	IN	_	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6677
# text = HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs.
1	HIV	haHive	NOUN	NN	Number=Sing	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
9	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	MDMs	Mdms	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6678
# text = The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
10	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
11	time	time	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	partially	partially	ADV	RB	_	_	_	_	_
16	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
30	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6679
# text = The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	change	change	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6680
# text = Document 003001801 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001801	003001801	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6681
# text = A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
18	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6682
# text = Activation of the interleukin 2 (IL-2) gene after antigen recognition is a critical event for T cell proliferation and effector function.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
14	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	event	event	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6683
# text = Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes.
1	Prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6684
# text = Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell (NFAT) domain.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	immediately	immediately	ADV	RB	_	_	_	_	_
16	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	T	T	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6685
# text = This region (termed the zinc finger protein binding region (ZIP)) serves as binding site for two differently regulated zinc finger proteins: the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
7	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ZIP	ZIP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	differently	differently	ADV	RB	_	_	_	_	_
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
24	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	:	:	PUNCT	:	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	constitutively	constitutively	ADV	RB	_	_	_	_	_
29	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
36	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
37	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
38	response	response	NOUN	NN	Number=Sing	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6686
# text = In unstimulated cells which do not secrete IL-2, only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element.
1	In	in	ADP	IN	_	_	_	_	_
2	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	secrete	secrete	VERB	VB	VerbForm=Inf	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
14	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	secreting	secreting	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
29	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6687
# text = In Jurkat T cells, the ZIP site serves as an activator for IL-2 gene expression, and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ZIP	ZIP	PROPN	NNP	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	ZIP	ZIP	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NFAT	Nfat	SCONJ	IN	_	_	_	_	_
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6688
# text = These results suggest a critical role of the ZIP site for IL-2 promoter activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ZIP	ZIP	PROPN	NNP	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6689
# text = Document 003001809 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001809	003001809	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6690
# text = Involvement of Alu sequences in the cell-specific regulation of transcription of the gamma chain of Fc and T cell receptors.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Alu	Alu	PROPN	NNP	Number=Sing	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6691
# text = The Fc epsilon RI-gamma chains are expressed in a variety of hematopoietic cells where they play a critical role in signal transduction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
3	epsilon	epsilon	ADP	IN	_	_	_	_	_
4	RI	RI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	where	where	ADV	WRB	PronType=Rel	_	_	_	_
17	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
18	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6692
# text = They are part of the high affinity
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	part	part	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6693
# text = IgE receptor in mast cells, basophils, Langerhans cells, and possibly other cells; a component of the low affinity receptor for IgG (Fc gamma RIIIA or CD16) in natural killer cells and macrophages; and part of the T cell antigen receptor in subsets of T cells.
1	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	mast	mast	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Langerhans	Langerhans	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	possibly	possibly	ADV	RB	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	component	component	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
28	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
29	RIIIA	RIIIA	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	CD16	CD16	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
35	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	;	;	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	part	part	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	T	T	PROPN	NNP	Number=Sing	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	T	t	PROPN	NNP	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6694
# text = Here we have investigated the transcriptional regulation of the gamma chain gene by analyzing the 2.5-kilobase sequence upstream of the transcription start site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	analyzing	analyze	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	start	start	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6695
# text = This sequence contains a promoter specific to cells of hematopoietic lineage.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6696
# text = However, the tissue specificity of this promoter is only partial because it is active in all of the hematopoietic cells tested here, regardless of whether they constitutively express Fc epsilon RI- gamma chain transcripts.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
5	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
12	because	because	SCONJ	IN	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	all	all	DET	DT	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	regardless	regardless	ADV	RB	_	_	_	_	_
26	of	of	SCONJ	IN	_	_	_	_	_
27	whether	whether	SCONJ	IN	_	_	_	_	_
28	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
29	constitutively	constitutively	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
31	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
32	epsilon	epsilon	ADP	IN	_	_	_	_	_
33	RI	Ri	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	_
35	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
36	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
37	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6697
# text = We have identified two adjacent cis-acting regulatory elements, both of which are part of an Alu repeat.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	part	part	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	Alu	Alu	PROPN	NNP	Number=Sing	_	_	_	_
19	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6698
# text = The first (-445/-366) is a positive element active in both basophils and T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	-445/-	-445/-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	366	366	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6699
# text = The second (-365/-264) binds to nuclear factors, which appear to be different in basophils and T cells, and acts as a negative element in basophils and as a positive one in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	-365/-	-365/-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	264	264	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	T	t	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
35	one	one	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6700
# text = Thus, this Alu repeat (90% identical to Alu consensus sequences) has evolved to become both a positive and negative regulator.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	Alu	Alu	PROPN	NNP	Number=Sing	_	_	_	_
5	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	%	%	SYM	NN	Number=Sing	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	Alu	Alu	PROPN	NNP	Number=Sing	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	evolved	evolve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6701
# text = Document 003001811 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001811	003001811	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6702
# text = Differential autoregulation of glucocorticoid receptor expression in human T- and B-cell lines.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6703
# text = Regulation of glucocorticoid receptor (GR) expression by its cognate ligand was examined in the glucocorticoid-sensitive human leukemic T-cell line 6TG1.1 and in the human B-cell line IM-9.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
12	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukemic	leukemic	NOUN	NN	Number=Sing	_	_	_	_
22	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	_
25	6TG1.1	6tg1.1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	_
34	IM	Im	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6704
# text = In contrast to the decrease in GR mRNA seen in IM-9 cells after treatment with 1 microM dexamethasone for 16-18 h, treatment of 6TG1.1 cells resulted in an 8-fold increase in GR mRNA, as determined by Northern blot and RNase protection analysis, with a corresponding 3- to 4-fold increase in GR protein.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
9	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	IM	Im	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	9	9	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
20	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	18	18	NUM	CD	NumType=Card	_	_	_	_
25	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
37	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
40	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	as	as	SCONJ	IN	_	_	_	_	_
43	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
46	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	RNase	RNase	NOUN	NN	Number=Sing	_	_	_	_
49	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
50	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	with	with	ADP	IN	_	_	_	_	_
53	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
55	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	-	-	PUNCT	,	_	_	_	_	_
57	to	to	ADP	IN	_	_	_	_	_
58	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
61	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	GR	Gr	ADJ	JJ	Degree=Pos	_	_	_	_
64	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6705
# text = Half-maximal induction of GR mRNA and protein in 6TG1.1 cells was observed between 10-100 nM dexamethasone, and inclusion of 1 microM RU 38486 completely blocked the effects of 100 nM dexamethasone, demonstrating that positive autoregulation of GR expression in 6TG1.1 cells is a receptor-mediated response.
1	Half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	100	100	NUM	CD	NumType=Card	_	_	_	_
19	nM	nm	NUM	CD	NumType=Card	_	_	_	_
20	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	inclusion	inclusion	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	microM	microm	PROPN	NNP	Number=Sing	_	_	_	_
27	RU	RU	PROPN	NNP	Number=Sing	_	_	_	_
28	38486	38486	NUM	CD	NumType=Card	_	_	_	_
29	completely	completely	ADV	RB	_	_	_	_	_
30	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	100	100	NUM	CD	NumType=Card	_	_	_	_
35	nM	nm	NOUN	NN	Number=Sing	_	_	_	_
36	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
39	that	that	SCONJ	IN	_	_	_	_	_
40	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
41	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6706
# text = Positive autoregulation of GR expression was also observed in glucocorticoid-resistant CEM-C1 cells, which contain functional GR, but whose growth is unaffected by glucocorticoids.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GR	Gr	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
13	CEM	cem	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	C1	c1	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	unaffected	unaffect	ADJ	JJ	Degree=Pos	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6707
# text = Thus, positive autoregulation is neither a consequence nor the sole cause of growth arrest.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
4	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	neither	neither	DET	DT	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
9	nor	nor	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	sole	sole	ADJ	JJ	Degree=Pos	_	_	_	_
12	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6708
# text = The degree of negative autoregulation in IM-9 cells and positive autoregulation in 6TG1.1 cells was unaffected by inhibition of protein synthesis with cycloheximide.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	IM	Im	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	9	9	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	unaffected	unaffect	ADJ	JJ	Degree=Pos	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6709
# text = Measurement of GR mRNA turnover in 6TG1.1 cells treated with actinomycin-D revealed a half-life of 2.5 h, which was unaffected by dexamethasone treatment.
1	Measurement	Measurement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	actinomycin	actinomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	D	d	PROPN	NNP	Number=Sing	_	_	_	_
14	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	life	life	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	2.5	2.5	NUM	CD	NumType=Card	_	_	_	_
21	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	unaffected	unaffect	ADJ	JJ	Degree=Pos	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	dexamethasone	dexamethasone	ADJ	JJ	Degree=Pos	_	_	_	_
28	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6710
# text = A similar half-life was determined in IM-9 cells and was also unaffected by steroid treatment.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	life	life	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	IM	Im	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	9	9	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	unaffected	unaffect	ADJ	JJ	Degree=Pos	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6711
# text = These results are consistent with the interpretation that glucocorticoid-mediated autoregulation of GR expression is a tissue-specific primary transcriptional response.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	interpretation	interpretation	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	glucocorticoid	glucocorticoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	tissue-specific	tissue-specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6712
# text = Document 003001815 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001815	003001815	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6713
# text = Fcgamma receptor-mediated mitogen-activated protein kinase activation in monocytes is independent of Ras.
1	Fcgamma	Fcgamma	PROPN	NNP	Number=Sing	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6714
# text = Receptors for the Fc portion of immunoglobulin molecules (FcR) present on leukocyte cell membranes mediate a large number of cellular responses that are very important in host defense, including phagocytosis, cell cytotoxicity, production and secretion of inflammatory mediators, and modulation of the immune response.
1	Receptors	Receptor	NOUN	NNS	Number=Plur	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Fc	Fc	ADJ	JJ	Degree=Pos	_	_	_	_
5	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FcR	FcR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	_
17	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	very	very	ADV	RB	_	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	host	host	NOUN	NN	Number=Sing	_	_	_	_
30	defense	defense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
33	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	production	production	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
43	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
50	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6715
# text = Cross-linking of FcR with immune complexes leads, first to activation of protein-tyrosine kinases.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	FcR	FcR	PROPN	NNP	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	first	first	ADV	RB	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6716
# text = The molecular events that follow and that transduce signals from these receptors to the nucleus are still poorly defined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	follow	follow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	transduce	transduce	NOUN	NN	Number=Sing	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	still	still	ADV	RB	_	_	_	_	_
18	poorly	poorly	ADV	RB	_	_	_	_	_
19	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6717
# text = We have investigated the signal transduction pathway from Fc receptors that leads to gene activation and production of cytokines in monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
6	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	Fc	Fc	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6718
# text = Cross-linking of FcR, on the THP-1 monocytic cell line, by immune complexes resulted in both activation of the transcription factor NF-kappaB and interleukin 1 production.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	FcR	FcR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
19	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6719
# text = These responses were completely blocked by tyrosine kinase inhibitors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	completely	completely	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6720
# text = In contrast, expression of dominant negative mutants of Ras and Raf-1, in these cells, did not have any effect on FcR-mediated nuclear factor activation, suggesting that the mitogen-activated protein kinase (MAPK) signaling pathway was not used by these receptors.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
23	any	any	DET	DT	_	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	FcR-mediated	FcR-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
49	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6721
# text = However, MAPK activation was easily detected by in vitro kinase assays, after FcR cross-linking with immune complexes.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	easily	easily	ADV	RB	_	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	FcR	Fcr	NOUN	NN	Number=Sing	_	_	_	_
16	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6722
# text = Using the specific MAPK/extracellular signal-regulated kinase kinase (MAPK kinase) inhibitor PD98059, we found that MAPK activation is necessary for FcR-dependent activation of the nuclear factor NF-kappaB.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MAPK	MAPK	NUM	CD	NumType=Card	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	PD98059	Pd98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	FcR-dependent	FcR-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6723
# text = These results strongly suggest that the signaling pathway from Fc receptors leading to expression of different genes important to leukocyte biology, initiates with tyrosine kinases and requires MAPK activation; but in contrast to other tyrosine kinase receptors, FcR-mediated MAPK activation does not involve Ras and Raf.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	leukocyte	leukocyte	VERB	VB	VerbForm=Inf	_	_	_	_
21	biology	biology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
26	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	MAPK	Mapk	PROPN	NNP	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
37	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	FcR-mediated	FcR-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
42	MAPK	MAPK	NOUN	NN	Number=Sing	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
47	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6724
# text = Document 003001817 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001817	003001817	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6725
# text = In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
17	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
33	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	ADV	RB	_	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	abnormal	abnormal	VERB	VB	VerbForm=Inf	_	_	_	_
39	thymopoiesis	thymopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6726
# text = To understand the role of NF-kappa B complexes in T cell development and activation, we have generated transgenic mice in which RelA and c-Rel complexes were selectively inhibited in the T-lineage cells by specific expression of a trans-dominant form of I kappa B alpha.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
22	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
30	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	selectively	selectively	ADV	RB	_	_	_	_	_
33	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
47	form	form	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
50	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
51	B	b	PROPN	NNP	Number=Sing	_	_	_	_
52	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6727
# text = Transgene expression did not affect the thymic development, but led to lowered numbers of splenic T cells and to a dramatic decrease in the ex vivo proliferative response of splenic T lymphocytes.
1	Transgene	Transgene	PROPN	NNP	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
8	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	lowered	lower	ADJ	JJ	Degree=Pos	_	_	_	_
14	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
23	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	ex	ex	NOUN	NN	Number=Sing	_	_	_	_
27	vivo	vivo	ADP	IN	_	_	_	_	_
28	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	T	PROPN	NNP	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6728
# text = Analysis of IL-2 and IL-2R alpha expression demonstrated that the perturbation of the proliferation response was not attributable to an abnormal expression of these genes.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	perturbation	perturbation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6729
# text = In contrast, expression of IL-4, IL-10, and IFN-gamma was strongly inhibited in the transgenic T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	strongly	strongly	ADV	RB	_	_	_	_	_
20	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6730
# text = The proliferative deficiency of the transgenic T cells was associated with an increased apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
3	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6731
# text = These results point out the involvement of NF-kappa B/Rel family proteins in growth signaling pathways by either regulating proteins involved in the IL-2 signaling or by functionally interfering with the cell cycle progression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	point	point	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	out	out	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	either	either	CCONJ	CC	_	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	by	by	SCONJ	IN	_	_	_	_	_
33	functionally	functionally	ADV	RB	_	_	_	_	_
34	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
39	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6732
# text = Document 003001820 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001820	003001820	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6733
# text = Pentoxifylline for the treatment of infection with human immunodeficiency virus.
1	Pentoxifylline	Pentoxifylline	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6734
# text = Cytokine dysregulation in human immunodeficiency virus type 1 (HIV-1) infection has been documented in numerous studies and has been cited as an important component in the pathogenesis of this retroviral infection.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	_
2	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	documented	document	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
20	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	cited	cit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	component	component	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	retroviral	retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
35	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6735
# text = Pharmacological modification of cytokine dysregulation, therefore, has been suggested as a therapeutic modality for HIV-1 infection.
1	Pharmacological	Pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
2	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
15	modality	modality	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6736
# text = Dr. Dezube of Beth Israel Hospital (Boston) concisely reviews the state of our knowledge regarding the effects of pentoxifylline on expression of tumor necrosis factor-alpha, a cytokine known to influence HIV-1 replication and to play a possible role in the clinical manifestations of advanced infection with this virus.
1	Dr.	Dr.	PROPN	NNP	Number=Sing	_	_	_	_
2	Dezube	Dezube	PROPN	NNP	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Beth	Beth	PROPN	NNP	Number=Sing	_	_	_	_
5	Israel	Israel	PROPN	NNP	Number=Sing	_	_	_	_
6	Hospital	Hospital	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Boston	Boston	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	concisely	concisely	ADV	RB	_	_	_	_	_
11	reviews	review	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	state	state	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
16	knowledge	knowledge	NOUN	NN	Number=Sing	_	_	_	_
17	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	pentoxifylline	pentoxifylline	NOUN	NN	Number=Sing	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
35	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
44	role	role	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
48	manifestations	manifestation	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
51	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
52	with	with	ADP	IN	_	_	_	_	_
53	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
54	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6737
# text = Pentoxifylline, a trisubstituted xanthine derivative, has been used to decrease blood viscosity and is reasonably well tolerated by most recipients of the drug.
1	Pentoxifylline	Pentoxifylline	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	trisubstituted	trisubstitute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	xanthine	xanthine	NOUN	NN	Number=Sing	_	_	_	_
6	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	viscosity	viscosity	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	reasonably	reasonably	ADV	RB	_	_	_	_	_
18	well	well	ADV	RB	Degree=Pos	_	_	_	_
19	tolerated	tolerate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
22	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6738
# text = Results of preliminary studies, many of which were conducted by Dr. Dezube, suggest that use of this agent in combination with antiretroviral compounds may prove useful in the treatment of patients with HIV-1 infection.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	preliminary	preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Dr.	Dr.	PROPN	NNP	Number=Sing	_	_	_	_
13	Dezube	Dezube	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	use	use	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	antiretroviral	antiretroviral	ADJ	JJ	Degree=Pos	_	_	_	_
25	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
28	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6739
# text = Document 003001826 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001826	003001826	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6740
# text = DNA-binding studies of the Epstein-Barr virus nuclear antigen 2 (EBNA-2): evidence for complex formation by latent membrane protein gene promoter-binding proteins in EBNA-2-positive cell lines.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	EBNA	EBNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
22	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
25	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6741
# text = The Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) protein is essential for the immortalization of human primary B cells by EBV.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	EBNA	EBNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6742
# text = EBNA-2 trans-activates cellular and viral genes like CD23, c-fgr, latent membrane protein 1 (LMP1) and terminal protein 1 (TP1).
1	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	like	like	ADP	IN	_	_	_	_	_
12	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	fgr	fgr	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
18	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TP1	TP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6743
# text = Trans-activation of the TP1 promoter and of the BamHI C promoter has already been investigated in detail and appears to be mediated via protein-protein interactions and not by direct binding of EBNA-2 type A (of EBV type 1) to the DNA.
1	Trans-	Trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TP1	tP1	PROPN	NNP	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	_
11	C	C	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	already	already	ADV	RB	_	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	detail	detail	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
32	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	type	type	NOUN	NN	Number=Sing	_	_	_	_
38	A	a	SYM	SYM	_	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	of	of	ADP	IN	_	_	_	_	_
41	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
42	type	type	NOUN	NN	Number=Sing	_	_	_	_
43	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	DNA.	DNA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 6744
# text = EBNA-2 is able to trans-activate the expression of the LMP gene in several cell lines.
1	EBNA	EBNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6745
# text = Various reports have delineated the cis-acting elements of the LMP promoter through which EBNA-2 mediates trans-activation.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	delineated	delineate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
20	trans-	trans-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6746
# text = To determine whether EBNA-2 also trans-activates the LMP promoter by protein-protein interactions, we performed a series of gel retardation assays and competition experiments with LMP promoter fragments of different sizes.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	trans	tran	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	series	series	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
26	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
29	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
36	sizes	size	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6747
# text = We determined that the protein-binding region on the LMP promoter was within a 42 bp fragment encompassing nucleotides -135 to -176 relative to the LMP transcriptional start site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	42	42	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
18	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	135	135	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	176	176	NUM	CD	NumType=Card	_	_	_	_
25	relative	relative	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	start	start	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6748
# text = None of the DNA fragments investigated indicated interaction of EBNA-2 with the DNA via protein-protein interactions.
1	None	none	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
6	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	indicated	indicated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6749
# text = No significant differences between EBNA-2-positive and EBNA-2-negative nuclear extracts could be seen in the gel retardation assay under conditions that clearly showed binding of EBNA-2A to the TP1 promoter.
1	No	no	DET	DT	_	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
24	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
25	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	clearly	clearly	ADV	RB	_	_	_	_	_
30	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	TP1	tP1	PROPN	NNP	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6750
# text = However, analysis of sucrose gradient fractions in the gel retardation assay provided evidence that the LMP promoter-binding proteins form a complex of higher M(r) in EBNA-2-positive cell extracts.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	sucrose	sucrise	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	gradient	gradient	ADJ	JJ	Degree=Pos	_	_	_	_
7	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
11	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
13	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	form	from	ADP	IN	Typo=Yes	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
27	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	r	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6751
# text = These complexes were destroyed by detergent.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	destroyed	destroy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	detergent	detergent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6752
# text = We deduce from these results that EBNA-2-positive cells might indeed contain specific complexes bound to the LMP promoter which are, however, too labile to be detected in a standard gel retardation assay.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	deduce	deduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
14	indeed	indeed	ADV	RB	_	_	_	_	_
15	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
18	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	LMP	Lmp	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	too	too	ADV	RB	_	_	_	_	_
29	labile	labile	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
32	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	standard	standard	ADJ	JJ	Degree=Pos	_	_	_	_
36	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
37	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
38	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6753
# text = Document 003001831 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001831	003001831	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6754
# text = Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation.
1	Immunosuppressant	Immunosuppressant	PROPN	NNP	Number=Sing	_	_	_	_
2	PG490	PG490	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	triptolide	triptolide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
7	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6755
# text = PG490 (triptolide) is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties.
1	PG490	PG490	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	triptolide	triptolide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	diterpene	diterpene	NOUN	NN	Number=Sing	_	_	_	_
8	triepoxide	triepoxide	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
11	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6756
# text = PG490 inhibits interleukin(IL)-2 expression by normal human peripheral blood lymphocytes stimulated with phorbol 12-myristate 13-acetate (PMA) and antibody to CD3 (IC50 of 10 ng/ml), and with PMA and ionomycin (Iono, IC50 of 40 ng/ml).
1	PG490	PG490	NUM	CD	NumType=Card	_	_	_	_
2	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
19	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
22	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	IC50	IC50	NUM	CD	NumType=Card	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	10	10	NUM	CD	NumType=Card	_	_	_	_
36	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	Iono	Iono	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	IC50	IC50	NUM	CD	NumType=Card	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	40	40	NUM	CD	NumType=Card	_	_	_	_
51	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6757
# text = In Jurkat T-cells, PG490 inhibits PMA/Iono-stimulated IL-2 transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	PG490	PG490	NUM	CD	NumType=Card	_	_	_	_
7	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
8	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	Iono	Iono	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6758
# text = PG490 inhibits the induction of DNA binding activity at the purine-box/antigen receptor response element (ARRE)/nuclear factor of activated T-cells (NF-AT) target sequence but not at the NF-kappaB site.
1	PG490	PG490	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	ARRE	ARRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	target	target	NOUN	NN	Number=Sing	_	_	_	_
35	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	at	at	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
43	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6759
# text = PG490 can completely inhibit transcriptional activation at the purine-box/ARRE/NF-AT and NF-kappaB target DNA sequences triggered by all stimuli examined (PMA, PMA/Iono, tumor necrosis factor-alpha).
1	PG490	PG490	NOUN	NN	Number=Sing	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	completely	completely	ADV	RB	_	_	_	_	_
4	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-box/ARRE/NF-AT	-box/arre/nf-at	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
15	target	target	NOUN	NN	Number=Sing	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
18	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	all	all	DET	DT	_	_	_	_	_
21	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
22	examined	examine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Iono	Iono	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
31	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6760
# text = PG490 also inhibits PMA-stimulated activation of a chimeric transcription factor in which the C-terminal TA1 transactivation domain of NF-kappaB p65 is fused to the DNA binding domain of GAL4.
1	PG490	PG490	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
18	TA1	tA1	NUM	CD	NumType=Card	_	_	_	_
19	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	fused	fused	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	GAL4	GAL4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6761
# text = In 16HBE human bronchial epithelial cells, IL-8 expression is regulated predominantly by NF-kappaB, and PG490 but not cyclosporin A can completely inhibit expression of IL-8.
1	In	in	ADP	IN	_	_	_	_	_
2	16HBE	16hbe	ADJ	JJ	Degree=Pos	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
5	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	predominantly	predominantly	ADV	RB	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	PG490	PG490	NUM	CD	NumType=Card	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
25	A	a	NOUN	NN	Number=Sing	_	_	_	_
26	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
27	completely	completely	ADV	RB	_	_	_	_	_
28	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6762
# text = The mechanism of PG490 inhibition of cytokine gene expression differs from cyclosporin
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PG490	PG490	NUM	CD	NumType=Card	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6763
# text = A and involves nuclear inhibition of transcriptional activation of NF-kappaB and the purine-box regulator operating at the ARRE/NF-AT site at a step after specific DNA binding.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
19	operating	operating	VERB	VBG	VerbForm=Ger	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	ARRE	ARRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	step	step	NOUN	NN	Number=Sing	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6764
# text = Document 003001835 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001835	003001835	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6765
# text = NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	proapoptotic	proapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6766
# text = Recently NF-kappaB has been shown to have both proapoptotic and antiapoptotic functions.
1	Recently	recently	ADV	RB	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	proapoptotic	proapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
14	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6767
# text = In T cell hybridomas, both T cell activators and glucocorticoids induce apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
12	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6768
# text = Here we show that blockade of NF-kappaB activity, using a dominant negative IkappaBalpha, has opposite effects on these two apoptotic signals.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
15	negative	negative	NOUN	NN	Number=Sing	_	_	_	_
16	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
20	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	two	two	NUM	CD	NumType=Card	_	_	_	_
24	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
25	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6769
# text = Treatment with PMA plus ionomycin (P/I) results in the upregulation of Fas Ligand (FasL) and induction of apoptosis.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
4	plus	plus	CCONJ	CC	_	_	_	_	_
5	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	P/	P/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
16	Ligand	Ligand	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	FasL	FasL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6770
# text = Inhibition of NF-kappaB activity inhibits the P/I mediated induction of FasL mRNA and decreases the level of apoptosis in these cultures, thus establishing NF-kappaB as a proapoptotic factor in this context.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	P/	p/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	FasL	FasL	PROPN	NNP	Number=Sing	_	_	_	_
15	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	thus	thus	ADV	RB	_	_	_	_	_
27	establishing	establish	VERB	VBG	VerbForm=Ger	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	proapoptotic	proapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6771
# text = Conversely, inhibition of NF-kappaB confers a tenfold increase in glucocorticoid mediated apoptosis, establishing that NF-kappaB also functions as an antiapoptotic factor.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	tenfold	tenfold	NOUN	NN	Number=Sing	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	establishing	establish	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6772
# text = We conclude that NF-kappaB is a context-dependent apoptosis regulator.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
13	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6773
# text = Our data suggests that NF-kappaB may function as an antiapoptotic factor in thymocytes while functioning as a proapoptotic factor in mature peripheral T cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	functioning	function	VERB	VBG	VerbForm=Ger	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	proapoptotic	proapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6774
# text = Document 003001837 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001837	003001837	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6775
# text = Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway.
1	Immune	Immune	PROPN	NNP	Number=Sing	_	_	_	_
2	hyperactivation	hyperactivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6776
# text = Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of immune hyperactivation in patients.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
18	state	state	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	hyperactivation	hyperactivation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6777
# text = Infection of human peripheral blood lymphocytes with HIV-1 in vitro resulted in increased interleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
13	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	via	via	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
36	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6778
# text = Expression of the HIV-1 transactivator
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6779
# text = Tat recapitulated this phenotype and was associated with increased IL-2 secretion in response to costimulation with CD3 plus CD28.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	recapitulated	recapitulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	costimulation	costimulation	VERB	VB	VerbForm=Inf	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
20	plus	plus	CCONJ	CC	_	_	_	_	_
21	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6780
# text = IL-2 superinduction by
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	superinduction	superinduction	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_

# sent_id = 6781
# text = Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	exclusively	exclusively	ADV	RB	_	_	_	_	_
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	29	29	NUM	CD	NumType=Card	_	_	_	_
30	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
31	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
32	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
36	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6782
# text = Document 003001844 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001844	003001844	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6783
# text = Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	attenuates	attenuate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6784
# text = Death-inducing ligands (DILs) such as tumor necrosis factor alpha (TNFalpha) or the cytotoxic drug doxorubicin have been shown to activate a nuclear factor kappaB (NFkappaB)-dependent program that may rescue cells from apoptosis induction.
1	Death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	inducing	inducing	NOUN	NN	Number=Sing	_	_	_	_
4	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	DILs	DIL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
20	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
21	doxorubicin	doxorubicin	NOUN	NN	Number=Sing	_	_	_	_
22	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	program	program	NOUN	NN	Number=Sing	_	_	_	_
37	that	that	PRON	WDT	PronType=Rel	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	rescue	rescue	VERB	VB	VerbForm=Inf	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6785
# text = We demonstrate here that TRAIL (TNF-related apoptosis-inducing ligand), a recently identified DIL, also activates NFkappaB in lymphoid cell lines in a kinetic similar to TNFalpha.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	TRAIL	trail	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	recently	recently	ADV	RB	_	_	_	_	_
18	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	DIL	Dil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	kinetic	kinetic	ADJ	JJ	Degree=Pos	_	_	_	_
31	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6786
# text = NFkappaB activity is independent from FADD, caspases, and apoptosis induction.
1	NFkappaB	Nfkappab	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	FADD	fadd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	caspases	caspase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6787
# text = To study the influence of NFkappaB activity on apoptosis mediated by TRAIL, CD95, TNFalpha, or doxorubicin, NFkappaB activation was inhibited using the proteasome inhibitor N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal or transient overexpression of mutant IkappaBalpha.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NFkappaB	NFkappaB	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	TRAIL	trail	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	doxorubicin	doxorubicin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
28	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
29	N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal	N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal	ADJ	JJ	Degree=Pos	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
32	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
35	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6788
# text = Sensitivity for induction of apoptosis was markedly increased by these treatments in apoptosis sensitive cell lines.
1	Sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	markedly	markedly	ADV	RB	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	treatments	treatment	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6789
# text = Moreover, both in cell lines and in primary leukemia cells that are resistant towards induction of apoptosis by DILs and doxorubicin, antagonization of NFkappaB activity partially restored apoptosis sensitivity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
15	towards	towards	ADP	IN	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	DILs	DIL	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	doxorubicin	doxorubicin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	antagonization	antagonization	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	partially	partially	ADV	RB	_	_	_	_	_
29	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6790
# text = These data suggest that inhibition of NFkappaB activation may provide a molecular approach to increase apoptosis sensitivity in anticancer treatment.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NFkappaB	Nfkappab	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
16	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	anticancer	anticancer	ADJ	JJ	Degree=Pos	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6791
# text = Document 003001845 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001845	003001845	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6792
# text = Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3. CD14, a monocyte/macrophage receptor for the complex of LPS and LPS binding protein, is a differentiation marker for the monocyte/macrophage lineage.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	14	14	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-dihydroxyvitamin	-dihydroxyvitamin	ADJ	JJ	Degree=Pos	_	_	_	_
14	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n
16	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
36	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
42	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6793
# text = We have analyzed the regulation of CD14 expression during 1 alpha,25-dihydroxyvitamin D3 (VitD3)-induced monocytic differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	14	14	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-dihydroxyvitamin	-dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
14	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6794
# text = Using FACS, Northern blotting, and nuclear run-on analyses, we demonstrate that the up-regulation of CD14 expression during monocytic cell maturation is regulated mainly at the level of gene transcription, and that new protein synthesis is required for CD14 induction.
1	Using	use	AUX	VBG	VerbForm=Ger	_	_	_	_
2	FACS	Fac	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
5	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	on	on	ADP	IN	_	_	_	_	_
12	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	14	14	NUM	CD	NumType=Card	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	mainly	mainly	ADV	RB	_	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	CD14	CD14	NUM	CD	NumType=Card	_	_	_	_
48	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6795
# text = We have recently cloned the CD14 5' upstream sequence and demonstrated its tissue-specific promoter activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	14	14	NUM	CD	NumType=Card	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	_
10	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6796
# text = Using stable transfection of the monocytoid U937 cell line with a series of deletion mutants of the CD14 5' upstream sequence coupled to a reporter gene construct, we show that bp -128 to -70 is the critical region for the induction of CD14 expression.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monocytoid	monocytoid	NOUN	NN	Number=Sing	_	_	_	_
7	U937	U937	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	series	series	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
15	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	14	14	NUM	CD	NumType=Card	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	``	_	_	_	_	_
22	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
35	-128	-128	NUM	CD	NumType=Card	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	70	70	NUM	CD	NumType=Card	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
42	region	region	NOUN	NN	Number=Sing	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	14	14	NUM	CD	NumType=Card	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6797
# text = This region contains two binding sites for the Sp1 transcription factor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6798
# text = A 3-bp mutation at the distal Sp1-binding site not only eliminates Sp1 interaction, but also abolishes most of the VitD3 induction of CD14 expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	eliminates	eliminate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	abolishes	abolish	ADV	RB	_	_	_	_	_
22	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	14	14	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6799
# text = Electrophoretic mobility shift analysis does not detect a direct interaction of the CD14 distal Sp1-binding site with the vitamin D3 receptor and its partner, the retinoid X receptor.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	14	14	NUM	CD	NumType=Card	_	_	_	_
15	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
16	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-binding	-bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
22	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	partner	partner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	_
30	X	x	ADP	IN	_	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6800
# text = These data demonstrate that VitD3 induces CD14 indirectly through some intermediary factor, and suggest a critical role for Sp1 in this process.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	14	14	NUM	CD	NumType=Card	_	_	_	_
9	indirectly	indirectly	ADV	RB	_	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	some	some	DET	DT	_	_	_	_	_
12	intermediary	intermediary	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
19	role	role	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6801
# text = Document 003001847 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001847	003001847	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6802
# text = Activation of the transcription factor NF-kappaB in lipopolysaccharide-stimulated U937 cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	U937	U937	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6803
# text = During the course of serious bacterial infections, lipopolysaccharide (LPS) interacts with monocyte/macrophage receptors, resulting in the generation of inflammatory cytokines.
1	During	during	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	course	course	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	serious	serious	ADJ	JJ	Degree=Pos	_	_	_	_
6	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
7	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	interacts	interacts	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6804
# text = Transcription factor NF-kappaB is crucial in activating the transcription of genes encoding proinflammatory cytokines.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
15	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6805
# text = In this paper, we demonstrate that the activation of NF-kappaB by LPS in a promonocytic cell line (U937) followed a rather slow kinetics, depending on the rate of IkappaB-alpha inhibitor hydrolysis.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	followed	follow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	rather	rather	ADV	RB	_	_	_	_	_
27	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
28	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
39	hydrolysis	hydrolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6806
# text = No degradation of p105 and p100 inhibitors was observed under these conditions.
1	No	no	DET	DT	_	_	_	_	_
2	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p105	p105	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p100	p100	NUM	CD	NumType=Card	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	under	under	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6807
# text = The transduction pathway leading to NF-kappaB activation in U937 cells involved the intracellular generation of reactive oxygen species (ROS), as demonstrated by the concomitant inhibitory effects of antioxidants on NF-kappaB activation and the emission of a fluorescent probe reacting intracellularly with hydrogen peroxide.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
20	species	species	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
30	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	emission	emission	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	fluorescent	fluorescent	ADJ	JJ	Degree=Pos	_	_	_	_
45	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
46	reacting	reacte	VERB	VBG	VerbForm=Ger	_	_	_	_
47	intracellularly	intracellularly	ADV	RB	_	_	_	_	_
48	with	with	ADP	IN	_	_	_	_	_
49	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
50	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6808
# text = This ROS pathway was also characterized by the use of other inhibitors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	ROS	Ros	NOUN	NN	Number=Sing	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	use	use	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6809
# text = This finding indicates that phospholipase A2 and 5-lipoxygenase are also involved.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
6	A2	A2	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6810
# text = However, the NF-kappaB activation pathway involving the acidic sphingomyelinase of the endolysosomial membrane did not seem to participate in the LPS-induced NF-kappaB activation in U937 cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
12	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	endolysosomial	endolysosomial	ADJ	JJ	Degree=Pos	_	_	_	_
16	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	seem	seem	VERB	VB	VerbForm=Inf	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	U937	U937	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6811
# text = Document 003001849 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001849	003001849	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6812
# text = Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
7	hemin-	hemin-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
10	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	K562	K562	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6813
# text = Acquisition of heat shock factor 2 (HSF2) DNA binding activity is accompanied by induced transcription of heat shock genes in hemin-treated K562 cells undergoing erythroid differentiation.
1	Acquisition	Acquisition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
4	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
20	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	hemin-	hemin-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	K562	K562	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	undergoing	undergoing	VERB	VBG	VerbForm=Ger	_	_	_	_
28	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6814
# text = Previous studies revealed that HSF2 consists of two alternatively spliced isoforms, HSF2-alpha and HSF2-beta, whose relative abundance is developmentally regulated and varies between different tissues.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	_
6	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	alternatively	alternatively	ADV	RB	_	_	_	_	_
10	spliced	splice	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	HSF2	Hsf2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
22	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
23	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	developmentally	developmentally	ADV	RB	_	_	_	_	_
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	varies	varies	NOUN	NNS	Number=Plur	_	_	_	_
29	between	between	ADP	IN	_	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6815
# text = To investigate whether the molar ratio of HSF2-alpha and HSF2-beta isoforms is crucial for the activation of HSF2 and whether the HSF2 isoforms play functionally distinct roles during the hemin-mediated erythroid differentiation, we generated cell clones expressing different levels of HSF2-alpha and HSF2-beta.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molar	molar	ADJ	JJ	Degree=Pos	_	_	_	_
6	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	whether	whether	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	_
27	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
28	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
29	functionally	functionally	ADV	RB	_	_	_	_	_
30	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
31	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
32	during	during	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	hemin-	hemin-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
43	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
44	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	HSF2	Hsf2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6816
# text = We show that in parental K562 cells, the HSF2-alpha isoform is predominantly expressed and HSF2 can be activated upon hemin treatment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
6	K562	K562	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	predominantly	predominantly	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	HSF2	Hsf2	NUM	CD	NumType=Card	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	upon	upon	ADP	IN	_	_	_	_	_
23	hemin	hemin	ADJ	JJ	Degree=Pos	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6817
# text = In contrast, when HSF2-beta is expressed at levels exceeding those of endogenous HSF2-alpha, the hemin-induced DNA binding activity and transcription of heat shock genes are repressed, whereas overexpression of HSF2-alpha results in an enhanced hemin response.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	when	when	ADV	WRB	PronType=Int	_	_	_	_
5	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	exceeding	exceed	VERB	VBG	VerbForm=Ger	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	hemin-	hemin-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
30	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	whereas	whereas	SCONJ	IN	_	_	_	_	_
36	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
41	results	result	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6818
# text = Furthermore, the hemin-induced accumulation of globin, known as a marker of erythroid differentiation, is decreased in cells overexpressing HSF2-beta.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hemin-	hemin-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
23	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6819
# text = We suggest that HSF2-beta acts as a negative regulator of HSF2 activity during hemin-mediated erythroid differentiation of K562 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HSF2	HSF2	NUM	CD	NumType=Card	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	hemin-	hemin-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	K562	K562	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6820
# text = Document 003001850 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001850	003001850	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6821
# text = Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6822
# text = The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
6	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6823
# text = Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6824
# text = The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	nor	nor	CCONJ	CC	_	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
39	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
40	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
41	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6825
# text = Document 003001852 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001852	003001852	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6826
# text = Involvement of intracellular Ca2+ in oxidant-induced NF-kappa B activation.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6827
# text = In human Jurkat T cells and its subclone Wurzburg cells oxidant challenge elevated [Ca2+]i by mobilizing Ca2+ from intracellular stores.
1	In	in	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
8	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	subclone	subclone	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	Wurzburg	Wurzburg	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
13	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	_
14	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	mobilizing	mobilize	VERB	VBG	VerbForm=Ger	_	_	_	_
22	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+	+	SYM	SYM	_	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	stores	store	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6828
# text = In Jurkat cells this effect was rapid and transient, but in Wurzburg cells the response was slow and sustained.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Wurzburg	Wurzburg	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	sustained	sustain	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6829
# text = H2O2-induced NF-kappaB activation in Wurzburg cells was not influenced by the presence of extracellular EGTA but was totally inhibited in cells that were loaded with esterified EGTA.
1	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Wurzburg	Wurzburg	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	EGTA	EGTA	PROPN	NNP	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	totally	totally	ADV	RB	_	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	loaded	load	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	esterified	esterify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	EGTA	EGTa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6830
# text = In Jurkat cells that are not sensitive to H2O2-induced NF-kappaB activation, H2O2 potentiated NF-kappaB activation in the presence of sustained high [Ca2+]i following thapsigargin treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	H2O2	h2o2	PART	TO	Abbr=Yes	_	_	_	_
17	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
28	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
31	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
34	thapsigargin	thapsigargin	ADJ	JJ	Degree=Pos	_	_	_	_
35	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6831
# text = NF-kappaB regulatory effect of alpha-lipoate and N-acetylcysteine appeared to be, at least in part, due to their ability to stabilize elevation of [Ca2+]i following oxidant challenge.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	lipoate	lipoate	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	N-	N-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	acetylcysteine	acetylcysteine	PRON	PRP	_	_	_	_	_
13	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	at	at	ADV	RB	_	_	_	_	_
18	least	least	ADV	RBS	Degree=Sup	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	due	due	ADP	IN	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	stabilize	stabilize	VERB	VB	VerbForm=Inf	_	_	_	_
28	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
33	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
35	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
36	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
37	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6832
# text = Results of this study indicate that a sustained elevated [Ca2+]i is a significant factor in oxidant-induced NF-kappaB activation.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	indicate	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	sustained	sustain	ADJ	JJ	Degree=Pos	_	_	_	_
9	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
13	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6833
# text = Document 003001853 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001853	003001853	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6834
# text = Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6.
1	Pancreatic	Pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
2	islet	islet	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
13	hepatocyte	hepatocyte	ADV	RB	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	3gamma	3gamma	INTJ	UH	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4gamma	4gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6835
# text = The genes encoding the functionally related hepatocyte nuclear factors HNF-1alpha and HNF-4alpha play a critical role in normal pancreatic beta-cell function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	functionally	functionally	ADV	RB	_	_	_	_	_
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	hepatocyte	hepatocyte	NOUN	NN	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	HNF	Hnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-4alpha	-4alpha	PROPN	NNP	Number=Sing	_	_	_	_
17	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6836
# text = Mutations in these liver-enriched transcription factors result in two forms of early-onset type 2 diabetes (maturity-onset diabetes of the young [MODY]), MODY3 and MODY1, which are characterized by impaired glucose-stimulated insulin secretion, early disease onset, and autosomal dominant inheritance.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	liver	liver	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	early	early	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	maturity	maturity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
24	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
28	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	MODY	MODY	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	MODY3	MODY3	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	MODY1	mody1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	which	which	PRON	WDT	PronType=Rel	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	glucose	glucose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	insulin	insulin	ADP	IN	_	_	_	_	_
46	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
49	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
50	onset	onset	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	autosomal	autosomal	ADJ	JJ	Degree=Pos	_	_	_	_
54	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
55	inheritance	inheritance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6837
# text = The transcriptional hierarchy of HNFs suggests that other proteins of the regulatory cascade might be responsible for other forms of MODY and/or late-onset type 2 diabetes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	hierarchy	hierarchy	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HNFs	Hnfs	PROPN	NNP	Number=Sing	_	_	_	_
6	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
14	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	MODY	MODy	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	or	or	CCONJ	CC	_	_	_	_	_
25	late	late	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6838
# text = In this study, we show that HNF-3alpha, -3beta, -3gamma, -4gamma, and -6 are expressed in pancreatic beta-cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	3gamma	3gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4gamma	4gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6839
# text = We report the identification and characterization of simple tandem repeat DNA polymorphisms in the genes encoding HNF-3alpha, -3beta, -3gamma, -4gamma, and -6 and the mapping of HNF-6 to chromosome bands 15q21.1-21.2 by fluorescence in situ hybridization.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	simple	simple	ADJ	JJ	Degree=Pos	_	_	_	_
9	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
10	repeat	repeat	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
17	HNF	Hnf	ADV	RB	_	_	_	_	SpaceAfter=No
18	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	3gamma	3gamma	INTJ	UH	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4gamma	4gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	6	6	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	6	6	NUM	CD	NumType=Card	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	chromosome	chromosome	DET	DT	_	_	_	_	_
43	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
44	15q21.1	15q21.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
46	21.2	21.2	NUM	CD	NumType=Card	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
51	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6840
# text = These markers will be useful to study the role of genetic variation in these genes in the pathogenesis of type 2 diabetes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
3	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
12	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6841
# text = Document 003001854 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001854	003001854	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6842
# text = Steel factor affects SCL expression during normal erythroid differentiation.
1	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6843
# text = Steel factor is one of the growth factors that controls the proliferation and differentiation of hematopoietic cells and SCL, also known as Tcl-5 or Tal-1, is a transcription factor involved in erythropoiesis.
1	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	Tcl	Tcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	5	5	NUM	CD	NumType=Card	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	Tal	Tal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	erythropoiesis	erythropoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6844
# text = In this report, we studied the role of SCL in the proliferation of human peripheral blood burst-forming unit-erythroid (BFU-E) and the effects of Steel factor on SCL expression in proliferating erythroid cells. BFU-E-derived colonies increase progressively in size, as determined by cell number, from day 7 to day 14 of culture, with the greatest increase in colony size (10-fold expansion) occurring between day 7 and day 10.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	burst	burst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
21	unit-erythroid	unit-erythroid	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	BFU	BFU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	E	e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	on	on	ADP	IN	_	_	_	_	_
34	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	SCONJ	IN	_	_	_	_	_
37	proliferating	proliferat	VERB	VBG	VerbForm=Ger	_	_	_	_
38	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells.	cells.	NOUN	NN	Number=Sing	_	_	_	_
40	BFU	BFU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-E	-E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
45	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
46	progressively	progressively	ADV	RB	_	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	size	size	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	as	as	SCONJ	IN	_	_	_	_	_
51	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	by	by	ADP	IN	_	_	_	_	_
53	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
54	number	number	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	from	from	ADP	IN	_	_	_	_	_
57	day	day	NOUN	NN	Number=Sing	_	_	_	_
58	7	7	NUM	CD	NumType=Card	_	_	_	_
59	to	to	ADP	IN	_	_	_	_	_
60	day	day	NOUN	NN	Number=Sing	_	_	_	_
61	14	14	NUM	CD	NumType=Card	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	with	with	ADP	IN	_	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	greatest	greatest	ADJ	JJS	Degree=Sup	_	_	_	_
68	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
69	in	in	ADP	IN	_	_	_	_	_
70	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
71	size	size	NOUN	NN	Number=Sing	_	_	_	_
72	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
73	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
74	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
75	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
76	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	)	)	PUNCT	-RRB-	_	_	_	_	_
78	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
79	between	between	ADP	IN	_	_	_	_	_
80	day	day	NOUN	NN	Number=Sing	_	_	_	_
81	7	7	NUM	CD	NumType=Card	_	_	_	_
82	and	and	CCONJ	CC	_	_	_	_	_
83	day	day	NOUN	NN	Number=Sing	_	_	_	_
84	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
85	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6845
# text = SCL protein levels in BFU-E-derived cells were highest in day 7 cells and decreased progressively from day 7 to day 14 of culture, suggesting an association of SCL with erythroid proliferation.
1	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	BFU	BFU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	E	e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	day	day	NOUN	NN	Number=Sing	_	_	_	_
15	7	7	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	progressively	progressively	ADV	RB	_	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	day	day	NOUN	NN	Number=Sing	_	_	_	_
22	7	7	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	day	day	NOUN	NN	Number=Sing	_	_	_	_
25	14	14	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	association	association	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	SCL	SCL	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
36	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6846
# text = In contrast, SCL mRNA levels did not decrease significantly between day 7 and day 14 cells, suggesting that posttranscriptional mechanisms are largely responsible for the decrease in SCL protein observed.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	SCL	Scl	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	day	day	NOUN	NN	Number=Sing	_	_	_	_
13	7	7	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	day	day	NOUN	NN	Number=Sing	_	_	_	_
16	14	14	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	largely	largely	ADV	RB	_	_	_	_	_
25	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6847
# text = The role of SCL in Steel factor-induced erythroid proliferation was then examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Steel	Steel	PROPN	NNP	Number=Sing	_	_	_	_
7	factor-induced	factor-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	then	then	ADV	RB	PronType=Dem	_	_	_	_
12	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6848
# text = In BFU-E-derived colonies cultured with Steel factor, colony size was significantly increased compared to control.
1	In	in	ADP	IN	_	_	_	_	_
2	BFU	BFU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-E	-E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
7	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
13	size	size	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	control	control	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6849
# text = In day 7 and day 10 erythroid precursors cultured with Steel factor, SCL protein was increased significantly compared to control.
1	In	in	ADP	IN	_	_	_	_	_
2	day	day	NOUN	NN	Number=Sing	_	_	_	_
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	day	day	NOUN	NN	Number=Sing	_	_	_	_
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
9	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	significantly	significantly	ADV	RB	_	_	_	_	_
19	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	control	control	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6850
# text = The increase in SCL protein levels in early erythroid precursors stimulated with Steel factor suggests one mechanism through which Steel factor may enhance normal erythroid proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	SCL	Scl	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	Steel	steel	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6851
# text = SCL mRNA levels assessed by Northern blot in day 7 cells did not increase significantly in response to Steel factor stimulation, suggesting that posttranscriptional mechanisms may also be important in the increase in SCL protein observed in response to Steel.
1	SCL	Scl	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	day	day	NOUN	NN	Number=Sing	_	_	_	_
10	7	7	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	Steel	Steel	VERB	VB	VerbForm=Inf	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
36	protein	protein	ADV	RB	_	_	_	_	_
37	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	Steel	Steel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6852
# text = Document 003001873 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001873	003001873	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6853
# text = AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.
1	AM580	AM580	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
5	benzoic	benzoic	ADJ	JJ	Degree=Pos	_	_	_	_
6	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
9	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
15	cyto-differentiating	cyto-differentiating	NOUN	NN	Number=Sing	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
19	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6854
# text = All-trans retinoic acid (ATRA) is successfully used in the cyto-differentiating treatment of acute promyelocytic leukemia (APL).
1	All	all	DET	DT	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
4	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	successfully	successfully	ADV	RB	_	_	_	_	_
11	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cyto-differentiating	cyto-differentiating	NOUN	NN	Number=Sing	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
18	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	APL	APL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6855
# text = Paradoxically, APL cells express PML-RAR, an aberrant form of the retinoic acid receptor type alpha (RAR alpha) derived from the leukemia-specific t(15;17) chromosomal translocation.
1	Paradoxically	paradoxically	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	PML	pMl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	RAR	Rar	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
12	form	form	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	RAR	Rar	X	GW	_	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	leukemia-specific	leukemia-specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	SpaceAfter=No
32	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
35	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6856
# text = We show here that AM580, a stable retinobenzoic derivative originally synthesized as a RAR alpha agonist, is a powerful inducer of granulocytic maturation in NB4, an APL-derived cell line, and in freshly isolated APL blasts.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	AM	am	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	580	580	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
10	retinobenzoic	retinobenzoic	NOUN	NN	Number=Sing	_	_	_	_
11	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
12	originally	originally	ADV	RB	_	_	_	_	_
13	synthesized	synthesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
23	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	APL	APL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	freshly	freshly	ADV	RB	_	_	_	_	_
40	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
42	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6857
# text = After treatment of APL cells with AM580 either alone or in combination with granulocyte colony-stimulating factor (G-CSF), the compound induces granulocytic maturation, as assessed by determination of the levels of leukocyte alkaline phosphatase, CD11b, CD33, and G-CSF receptor mRNA, at concentrations that are 10- to 100-fold lower than those of ATRA necessary to produce similar effects.
1	After	after	ADP	IN	_	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	AM	am	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	580	580	NUM	CD	NumType=Card	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
16	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
27	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	as	as	SCONJ	IN	_	_	_	_	_
32	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
40	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
41	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	CD11	CD11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	CD33	CD33	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
52	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
53	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	at	at	ADP	IN	_	_	_	_	_
56	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
57	that	that	PRON	WDT	PronType=Rel	_	_	_	_
58	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
59	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	-	-	SYM	SYM	_	_	_	_	_
61	to	to	ADP	IN	_	_	_	_	_
62	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
65	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
66	than	than	ADP	IN	_	_	_	_	_
67	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
68	of	of	ADP	IN	_	_	_	_	_
69	ATRA	Atra	PROPN	NNP	Number=Sing	_	_	_	_
70	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
71	to	to	PART	TO	_	_	_	_	_
72	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
73	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
74	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
75	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6858
# text = By contrast, AM580 is not effective as ATRA in modulating the expression of these differentiation markers in the HL-60 cell line and in freshly isolated granulocytes obtained from the peripheral blood of chronic myelogenous leukemia patients during the stable phase of the disease.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	AM	am	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	580	580	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	60	60	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	freshly	freshly	ADV	RB	_	_	_	_	_
29	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
35	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
38	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
40	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
41	during	during	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
44	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6859
# text = In NB4 cells, two other synthetic nonselective RAR ligands are capable of inducing LAP as much as AM580, whereas RAR beta- or RAR gamma-specific ligands are totally ineffective.
1	In	in	ADP	IN	_	_	_	_	_
2	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
8	nonselective	nonselective	ADJ	JJ	Degree=Pos	_	_	_	_
9	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
10	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
13	of	of	SCONJ	IN	_	_	_	_	_
14	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
15	LAP	lap	ADV	RB	_	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	AM580	AM580	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
23	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
27	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	totally	totally	ADV	RB	_	_	_	_	_
33	ineffective	ineffective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6860
# text = These results show that AM580 is more powerful than ATRA in modulating the expression of differentiation antigens only in cells in which PML-RAR is present.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	AM	am	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	580	580	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	more	more	ADV	RBR	_	_	_	_	_
9	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
10	than	than	ADP	IN	_	_	_	_	_
11	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6861
# text = Binding experiments, using COS-7 cells transiently transfected with PML-RAR and the normal RAR alpha, show that AM580 has a lower affinity than ATRA for both receptors.
1	Binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	COS	Cos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	transiently	transiently	ADV	RB	_	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	show	show	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
22	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	AM	am	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	580	580	NUM	CD	NumType=Card	_	_	_	_
25	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
28	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	ATRA	ATRa	PROPN	NNP	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	both	both	DET	DT	_	_	_	_	_
33	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6862
# text = However, in the presence of PML-RAR, the synthetic retinoid is a much better transactivator of retinoic acid-responsive element-containing promoters than the natural retinoid, whereas, in the presence of RAR alpha, AM580 and ATRA have similar activity.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
13	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
17	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
18	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
31	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
40	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	AM580	AM580	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
45	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6863
# text = This may explain the strong cyto-differentiating potential of AM580 in PML-RAR-containing leukemic cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
6	cyto-differentiating	cyto-differentiating	NOUN	NN	Number=Sing	_	_	_	_
7	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	AM	Am	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	580	580	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	PML	PML	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	RAR	RAR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6864
# text = Document 003001882 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001882	003001882	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6865
# text = Suppression of nuclear factor kappa B and CD18-mediated leukocyte adhesion to the corneal endothelium by dexamethasone.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CD18	CD18	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-mediated	-mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	corneal	corneal	NOUN	NN	Number=Sing	_	_	_	_
15	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6866
# text = PURPOSE: To demonstrate that leukocyte adhesion to cultured corneal endothelial cells is mediated by the CD18 antigen, and to determine whether dexamethasone directly suppresses adhesion by inhibiting activation of nuclear factor kappa B (NFkappaB).
1	PURPOSE	purpose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	To	to	PART	TO	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	corneal	corneal	NOUN	NN	Number=Sing	_	_	_	_
11	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	18	18	NUM	CD	NumType=Card	_	_	_	_
19	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
24	whether	whether	SCONJ	IN	_	_	_	_	_
25	dexamethasone	dexamethasone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	directly	directly	ADV	RB	_	_	_	_	_
27	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6867
# text = METHODS: Cultured bovine corneal endothelium was stimulated for 6 hours by 40 micron/ml tumor necrosis factor alpha (TNFalpha).
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Cultured	Culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
5	corneal	corneal	NOUN	NN	Number=Sing	_	_	_	_
6	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	40	40	NUM	CD	NumType=Card	_	_	_	_
14	micron	micron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6868
# text = Dexamethasone was added 1 hour before TNFalpha stimulation in the dexamethasone group.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
6	before	before	ADP	IN	_	_	_	_	_
7	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
12	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6869
# text = After stimulation, neutrophils separated from a healthy human volunteer were added with or without anti-CD18 antibody.
1	After	after	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
5	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	volunteer	volunteer	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	without	without	ADP	IN	_	_	_	_	_
16	anti-CD18	anti-CD18	NUM	CD	NumType=Card	_	_	_	_
17	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6870
# text = The culture plate was settled for 15 minutes at 37 degrees C, and then neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine for 5 minutes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
3	plate	plate	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	settled	settle	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	15	15	NUM	CD	NumType=Card	_	_	_	_
8	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	37	37	NUM	CD	NumType=Card	_	_	_	_
11	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
12	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	then	then	ADV	RB	PronType=Dem	_	_	_	_
16	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	formyl-methionyl-leucyl-phenylalanine	formyl-methionyl-leucyl-phenylalanine	NUM	CD	NumType=Card	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6871
# text = Nonadherent neutrophils were removed by sealing and inverting the culture well.
1	Nonadherent	Nonadherent	ADJ	JJ	Degree=Pos	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	removed	remove	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	SCONJ	IN	_	_	_	_	_
6	sealing	seal	VERB	VBG	VerbForm=Ger	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	inverting	invert	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6872
# text = The intracellular localization of NFkappaB after TNFalpha simulation was determined by confocal immunocytochemistry using an anti-p65 antibody.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	after	after	ADP	IN	_	_	_	_	_
7	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	simulation	simulation	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	confocal	confocal	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunocytochemistry	immunocytochemistry	NOUN	NN	Number=Sing	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	anti-p65	anti-p65	NUM	CD	NumType=Card	_	_	_	_
17	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6873
# text = RESULTS: Neutrophil adhesion to cultured corneal endothelial cells increased significantly on exposure to TNFalpha (451.4+/-45.4 cells/mm2, n = 16) compared to control (156.7+/-27.3 cells/mm2, n = 16, P < 0.01).
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Neutrophil	Neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	corneal	corneal	NOUN	NN	Number=Sing	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	451.4+/-45.4	451.4+/-45.4	NUM	CD	NumType=Card	_	_	_	_
18	cells/mm2	cells/mm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	n	not	NOUN	NN	Number=Sing	_	_	_	_
21	=	=	SYM	SYM	_	_	_	_	_
22	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	control	control	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	156.7+/-27.3	156.7+/-27.3	NUM	CD	NumType=Card	_	_	_	_
29	cells/mm2	cells/mm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	n	not	NOUN	NN	Number=Sing	_	_	_	_
32	=	=	SYM	SYM	_	_	_	_	_
33	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	P	p	NOUN	NN	Number=Sing	_	_	_	_
36	<	<	PUNCT	-LRB-	_	_	_	_	_
37	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6874
# text = This increased adhesion was suppressed by the addition of anti-CD18 antibody (157.6+/-25.1 cells/mm2, n = 8, P < 0.01) and by pretreatment with 10(-7) M dexamethasone (207.9+/-31.5 cells/mm2, n = 10, P < 0.01).
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	increased	increased	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	anti-CD	anti-cd	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	18	18	NUM	CD	NumType=Card	_	_	_	_
12	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	157.6+/-25.1	157.6+/-25.1	NUM	CD	NumType=Card	_	_	_	_
15	cells/mm2	cells/mm2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	n	not	NOUN	NN	Number=Sing	_	_	_	_
18	=	=	SYM	SYM	_	_	_	_	_
19	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	P	P	NOUN	NN	Number=Sing	_	_	_	_
22	<	<	PUNCT	-LRB-	_	_	_	_	_
23	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
31	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	M	m	NOUN	NN	Number=Sing	_	_	_	_
34	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	207.9+/-31.5	207.9+/-31.5	NUM	CD	NumType=Card	_	_	_	_
37	cells/	cells/	SYM	SYM	_	_	_	_	SpaceAfter=No
38	mm2	mm2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	n	not	NOUN	NN	Number=Sing	_	_	_	_
41	=	=	SYM	SYM	_	_	_	_	_
42	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	P	p	NOUN	NN	Number=Sing	_	_	_	_
45	<	<	PUNCT	-LRB-	_	_	_	_	_
46	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6875
# text = Immunocytochemistry 60 minutes after stimulation revealed that NFkappaB was located in the cytoplasm in unstimulated cells; however, the addition of TNFalpha caused NFkappaB to translocate into the nucleus.
1	Immunocytochemistry	Immunocytochemistry	PROPN	NNP	Number=Sing	_	_	_	_
2	60	60	NUM	CD	NumType=Card	_	_	_	_
3	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
24	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	translocate	translocate	VERB	VB	VerbForm=Inf	_	_	_	_
28	into	into	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6876
# text = Pretreatment with dexamethasone tapered NFkappaB translocation into the nucleus.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
4	tapered	taper	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
6	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6877
# text = CONCLUSIONS: Leukocyte adhesion to the corneal endothelium was shown to be mediated by CD18 expressed on activated leukocytes.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Leukocyte	Leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	corneal	corneal	ADJ	JJ	Degree=Pos	_	_	_	_
8	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	18	18	NUM	CD	NumType=Card	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6878
# text = Pretreatment of the endothelium with dexamethasone inhibited leukocyte adhesion; this may be due in part to the suppression of NFkappaB entry into the nucleus.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	due	due	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	part	part	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
23	into	into	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6879
# text = Document 003001885 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001885	003001885	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6880
# text = The B cell-specific nuclear factor OTF-2 positively regulates transcription of the human class II transplantation gene, DRA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B	b	NOUN	NN	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	OTF	Otf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	positively	positively	ADV	RB	_	_	_	_	_
12	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	class	class	NOUN	NN	Number=Sing	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6881
# text = The promoter of the major histocompatibility class II gene DRA contains an octamer element (ATTTGCAT) that is required for efficient DRA expression in B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
11	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	ATTTGCAT	ATTTGCAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
23	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6882
# text = Several DNA-binding proteins are known to bind this sequence.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6883
# text = The best characterized are the B cell-specific OTF-2 and the ubiquitous OTF-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
3	characterized	characterize	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	OTF	Otf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
16	OTF	OTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6884
# text = This report directly demonstrates that OTF-2 but not OTF-1 regulates the DRA gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	report	report	NOUN	NN	Number=Sing	_	_	_	_
3	directly	directly	ADV	RB	_	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	OTF	Otf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	OTF	Otf	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6885
# text = In vitro transcription analysis using protein fractions enriched for the octamer-binding protein OTF-2 demonstrate a positive functional role for OTF-2 in DRA gene transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
8	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	OTF	Otf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
21	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6886
# text = In contrast, OTF-1-enriched protein fractions did not affect DRA gene transcription although it functionally enhanced the transcription of another gene.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	OTF	OTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	although	although	SCONJ	IN	_	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	functionally	functionally	ADV	RB	_	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	another	another	DET	DT	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6887
# text = Recombinant OTF-2 protein produced by in vitro transcription/translation could also enhance DRA gene transcription in vitro.
1	Recombinant	Recombinant	NOUN	NN	Number=Sing	_	_	_	_
2	OTF	OTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
13	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
16	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6888
# text = In vivo transient transfection studies utilizing an OTF-2 expression vector resulted in similar findings: that OTF-2 protein enhanced DRA gene transcription, and that this effect requires an intact octamer element.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
4	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	utilizing	utilize	VERB	VBG	VerbForm=Ger	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	OTF	OTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
13	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
16	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
32	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
35	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
36	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6889
# text = Together these results constitute the first direct evidence of a positive role for the lymphoid-specific octamer-binding factor in DRA gene transcription.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	constitute	constitute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADV	RBS	_	_	_	_	_
7	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
8	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
24	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6890
# text = Document 003001888 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001888	003001888	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6891
# text = Modulation of the expression of the IFN-gamma receptor beta-chain controls responsiveness to IFN-gamma in human peripheral blood T cells.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
15	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
23	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6892
# text = IFN-gamma has potent antiproliferative and apoptotic effects in T cells that are important in determining T cell development and polarized differentiation.
1	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
6	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	development	development	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	polarized	polarize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6893
# text = Therefore, any event that enables T cells to become less responsive to IFN- gamma may potentially alter immune responsiveness to Ag.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	any	any	DET	DT	_	_	_	_	_
4	event	event	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	enables	enable	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
11	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	potentially	potentially	ADV	RB	_	_	_	_	_
19	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	Ag	ag	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6894
# text = In this work, we show that human peripheral blood T cells that are stimulated through the TCR and expanded with IL-2 are unresponsive to IFN-gamma, as determined by a lack of activation of jak kinases and the transcription factor, STAT1(alpha), a signal transducer and activator of transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	T	t	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	expanded	expand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	jak	jak	ADJ	JJ	Degree=Pos	_	_	_	_
41	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
54	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
55	and	and	CCONJ	CC	_	_	_	_	_
56	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6895
# text = This nonresponsiveness occurs because of a lack of expression of the beta- chain (accessory factor) of the IFN-gamma receptor, while at the same time maintaining IFN-gamma receptor alpha-chain expression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	nonresponsiveness	nonresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
3	occurs	occur	ADV	RB	_	_	_	_	_
4	because	because	ADP	IN	_	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	while	while	SCONJ	IN	_	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
30	time	time	NOUN	NN	Number=Sing	_	_	_	_
31	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
32	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
35	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6896
# text = Expression of the beta-chain can be restored by secondary TCR ligation or PMA treatment.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	restored	restore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
12	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
13	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6897
# text = T cell blasts treated with PMA are now responsive to IFN-gamma.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
4	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	now	now	ADV	RB	_	_	_	_	_
9	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6898
# text = When freshly isolated, highly enriched (>98%) T cells are examined for IFN-gamma responsiveness; these cells can respond to IFN-gamma and express beta-chain.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	freshly	freshly	ADV	RB	_	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	highly	highly	ADV	RB	_	_	_	_	_
6	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	>98	>98	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
19	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6899
# text = Therefore, as T cells progress from primary TCR activation through IL-2-dependent proliferation, followed by secondary TCR stimulation, their responsiveness to IFN-gamma varies, and this may affect their ability to participate in an ongoing immune response.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	progress	progress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
22	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	varies	varies	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
37	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
44	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
45	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6900
# text = Document 003001890 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001890	003001890	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6901
# text = Regulation of gene expression with double-stranded phosphorothioate oligonucleotides.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
10	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6902
# text = Alteration of gene transcription by inhibition of specific transcriptional regulatory proteins is necessary for determining how these factors participate in cellular differentiation.
1	Alteration	Alteration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	SCONJ	IN	_	_	_	_	_
15	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
16	how	how	ADV	WRB	PronType=Int	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6903
# text = The functions of these proteins can be antagonized by several methods, each with specific limitations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	antagonized	antagonize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	methods	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	each	each	DET	DT	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	limitations	limitation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6904
# text = Inhibition of sequence-specific DNA-binding proteins was achieved with double-stranded (ds) phosphorothioate oligonucleotides that contained octamer or kappa B consensus sequences.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ds	d	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
20	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
28	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6905
# text = The phosphorothioate oligonucleotides specifically bound either octamer transcription factor or nuclear factor (NF)-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
3	oligonucleotides	oligonucleotide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	specifically	specifically	ADV	RB	_	_	_	_	_
5	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6906
# text = The modified oligonucleotides accumulated in cells more effectively than standard ds oligonucleotides and modulated gene expression in a specific manner.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
4	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	effectively	effectively	ADV	RB	_	_	_	_	_
9	than	than	ADP	IN	_	_	_	_	_
10	standard	standard	ADJ	JJ	Degree=Pos	_	_	_	_
11	ds	d	NOUN	NNS	Number=Plur	_	_	_	_
12	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6907
# text = Octamer-dependent activation of a reporter plasmid or NF-kappa B-dependent activation of the human immunodeficiency virus (HIV) enhancer was inhibited when the appropriate phosphorothioate oligonucleotide was added to a transiently transfected B cell line.
1	Octamer	Octamer	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	when	when	ADV	WRB	PronType=Int	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
31	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
32	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	transiently	transiently	ADV	RB	_	_	_	_	_
38	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6908
# text = Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited interleukin-2 (IL-2) secretion to a degree similar to that observed with a mutated octamer site in the IL-2 enhancer.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	phosphorothioate	phosphorothioate	ADJ	JJ	Degree=Pos	_	_	_	_
4	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
9	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	leukemia	leukemia	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
28	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6909
# text = The ds phosphorothioate oligonucleotides probably compete for binding of specific transcription factors and may provide anti-viral, immunosuppressive, or other therapeutic effects.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ds	d	NOUN	NNS	Number=Plur	_	_	_	_
3	phosphorothioate	phosphorothioate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
5	probably	probably	ADV	RB	_	_	_	_	_
6	compete	compete	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	anti-viral	anti-viral	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
22	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6910
# text = Document 003001892 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001892	003001892	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6911
# text = Signals and nuclear factors that regulate the expression of interleukin-4 and interleukin-5 genes in helper T cells.
1	Signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	helper	helper	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6912
# text = Mouse thymoma line EL-4 cells produce cytokines such as interleukin (IL)-2, IL-3, IL-4, IL-10, and granulocyte-macrophage colony-stimulating factor in response to phorbol 12-myristate 13-acetate (PMA).
1	Mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
2	thymoma	thymoma	NOUN	NN	Number=Sing	_	_	_	_
3	line	line	NOUN	NN	Number=Sing	_	_	_	_
4	EL	el	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
35	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
43	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
46	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
48	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6913
# text = EL-4 cells also produce low levels of IL-5 when stimulated by PMA alone; however, cAMP greatly augments PMA-dependent IL-5 production.
1	EL	EL	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	5	5	NUM	CD	NumType=Card	_	_	_	_
13	when	when	ADV	WRB	PronType=Int	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
17	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
22	greatly	greatly	ADJ	JJ	Degree=Pos	_	_	_	_
23	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
24	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	5	5	NUM	CD	NumType=Card	_	_	_	_
30	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6914
# text = A transient transfection assay revealed that two signals, PMA and cAMP, are required for optimal activation of the IL-5 promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6915
# text = In contrast, cAMP almost completely inhibited the PMA-dependent activation of the endogenous IL-2 gene, as well as the transfected IL-2 promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cAMP	camp	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	almost	almost	ADV	RB	_	_	_	_	_
6	completely	completely	ADV	RB	_	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6916
# text = These results indicate that the IL-5 gene is positively regulated by cAMP in a manner opposite to that for the IL-2 gene.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	positively	positively	ADV	RB	_	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
18	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6917
# text = One of the nuclear factors (NFs) that regulates the response of the IL-5 promoter to cAMP and PMA has properties similar to NF for activated t cell.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NFs	Nfs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
23	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	NF	NF	VERB	VB	VerbForm=Inf	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	t	t	NOUN	NN	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6918
# text = The P sequence of the IL-4 gene, defined as a responsive element for PMA and calcium ionophore (A23187), shares sequence similarity with the NF kappa B and the NF-activated T cell binding sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	P	p	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	shares	share	NOUN	NNS	Number=Plur	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6919
# text = We attempted to determine whether NF(P), a nuclear factor specific for the P sequence, is related to NF-kappa B and nuclear factor for activated T cell (NF-AT).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	attempted	attempt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	AT	At	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6920
# text = In electromobility shift assays both NF-kappa B (P65 or P65/P50 heterodimer) and NF-AT bound to the P sequence.
1	In	in	ADP	IN	_	_	_	_	_
2	electromobility	electromobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	both	both	CCONJ	CC	_	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	B	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	P65	P65	NUM	CD	NumType=Card	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	P65	P65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
15	P50	P50	NUM	CD	NumType=Card	_	_	_	_
16	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	AT	AT	ADV	RB	_	_	_	_	_
22	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	P	p	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6921
# text = However, sequence specificity of NF-AT was more similar to that of NF(P), and only a small amount of P65 was detected in NF(P).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
24	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	P65	P65	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6922
# text = These results indicate that a component or components of NF-AT have the potential to reconstitute NF(P), whereas NF-kappa B alone does not account for NF(P) in Jurkat crude extract.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	component	component	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	components	component	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	AT	AT	PRON	WDT	PronType=Rel	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	reconstitute	reconstitute	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	alone	alone	ADV	RB	_	_	_	_	_
29	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
39	crude	crude	NOUN	NN	Number=Sing	_	_	_	_
40	extract	extract	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6923
# text = Taken together, these results suggest that NF-AT-like factors are involved in the regulation of IL-4 and IL-5 genes.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AT	AT	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	SCONJ	IN	_	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	5	5	NUM	CD	NumType=Card	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6924
# text = Document 003001910 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001910	003001910	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6925
# text = Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression.
1	Octamer	Octamer	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6926
# text = Antibodies are produced exclusively in B lymphocytes.
1	Antibodies	Antibody	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	exclusively	exclusively	ADV	RB	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6927
# text = The expression of the antibody-encoding genes, the immunoglobulin
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6928
# text = (Ig) genes, is also restricted to B cells.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	X	ADD	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6929
# text = The octamer sequence ATGCAAAT is present in the promoter and the enhancer of Ig genes, and plays an important role in its tissue-specific expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	ATGCAAAT	Atgcaaat	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6930
# text = This sequence motif is a binding site for nuclear proteins, the so-called octamer transcription factors (Oct or OTF factors).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
14	-called	-call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	OTF	OTF	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6931
# text = The Oct-1 protein is present in all cell types analyzed so far, whereas Oct-2A and Oct-2B are found mainly in B lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	types	type	NOUN	NNS	Number=Plur	_	_	_	_
12	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	so	so	ADV	RB	_	_	_	_	_
14	far	far	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	Oct-2A	Oct-2A	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	2B	2b	NOUN	NN	Number=Sing	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	mainly	mainly	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6932
# text = All three proteins show the same sequence specificity and binding affinity.
1	All	all	DET	DT	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6933
# text = It appears that the B cell-specific expression of Ig genes is mediated at least in part by cell type-specific
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	at	at	ADV	RB	_	_	_	_	_
16	least	least	ADV	RBS	Degree=Sup	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	part	part	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 6934
# text = Oct factors, and that there are both quantitative and qualitative differences between Oct-1 and Oct-2 factors.
1	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	there	there	PRON	EX	_	_	_	_	_
7	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	qualitative	qualitative	ADJ	JJ	Degree=Pos	_	_	_	_
12	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6935
# text = Recently, a number of other octamer factor variants were identified.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	number	number	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6936
# text = Many of these may be created by alternative splicing of a primary transcript of one Oct factor gene and may serve a specific function in the fine tuning of gene expression.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	created	create	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
9	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	fine	fine	ADJ	JJ	Degree=Pos	_	_	_	_
28	tuning	tuning	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6937
# text = Document 003001916 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001916	003001916	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6938
# text = Retinoblastoma protein expression leads to reduced Oct-1 DNA binding activity and enhances interleukin-8 expression.
1	Retinoblastoma	Retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	reduced	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
7	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	8	8	NUM	CD	NumType=Card	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6939
# text = Tumor cell lines with a defective retinoblastoma gene are unable to transcribe the HLA class II genes in response to IFN-gamma treatment, and reconstitution of functional Rb rescues IFN-gamma-induced class II gene expression.
1	Tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
7	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	transcribe	transcribe	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
15	class	class	NOUN	NN	Number=Sing	_	_	_	_
16	II	ii	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
30	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
31	rescues	rescue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	IFN-gamma	IFN-gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	class	class	NOUN	NN	Number=Sing	_	_	_	_
36	II	ii	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6940
# text = However, the molecular mechanism of Rb rescue of the class II genes is unknown.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
8	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	class	class	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6941
# text = We have examined the effect of Rb expression on the activation of the promoter for HLA-DRA, the prototype class II gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	prototype	prototype	NOUN	NN	Number=Sing	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	_
24	gene.	gene.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6942
# text = Oct-1, a POU domain transcription factor, was identified as a repressor of HLA-DRA promoter activity in the Rb-defective cells.
1	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	POU	POU	NOUN	NN	Number=Sing	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Rb-	Rb-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6943
# text = Rb expression led to phosphorylation of Oct-1, thus relieving its repressive effect. Oct-1 has also been shown to repress interleukin 8 promoter activity.
1	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	thus	thus	ADV	RB	_	_	_	_	_
11	relieving	relieve	VERB	VBG	VerbForm=Ger	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
14	effect.	effect	NOUN	NN	Number=Sing	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
24	interleukin	interleukin	ADV	RB	_	_	_	_	_
25	8	8	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6944
# text = Consistent with reduced levels of Oct-1 DNA binding activity in the Rb-transformed cell lines, interleukin 8 expression is higher in these cell lines.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Rb-	rb-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
19	8	8	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6945
# text = Document 003001917 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001917	003001917	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6946
# text = Inhibitor (IK) of IFN-gamma induced HLA class II antigens expression also inhibits HLA class II constitutive expression in the human Raji B cell line.
1	Inhibitor	Inhibitor	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IK	IK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
11	class	class	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	HLA	Hla	PROPN	NNP	Number=Sing	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6947
# text = The expression of major histocompatibility complex (MHC) class II antigens is constitutive in professional antigen presenting cells (APCs) but can also be induced by interferon-gamma (IFN-gamma) on the majority of the non professional APCs (e.g. fibroblasts).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	professional	professional	ADJ	JJ	Degree=Pos	_	_	_	_
17	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
18	presenting	presenting	VERB	VBG	VerbForm=Ger	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	APCs	APC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	on	on	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	non	non	X	AFX	_	_	_	_	_
43	professional	professional	ADJ	JJ	Degree=Pos	_	_	_	_
44	APCs	APC	NOUN	NNS	Number=Plur	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	e.g.	e.g.	X	FW	_	_	_	_	_
47	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6948
# text = We have recently characterised a new factor called IK which is an efficient inhibitor of IFN-gamma induction of MHC class II antigens expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	characterised	characterise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IK	IK	PROPN	NNP	Number=Sing	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	_
24	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6949
# text = Here, we demonstrate a novel role for IK in MHC class II expression since over-expression of this protein by stable transfection into human B cells led to a total disappearance of constitutive MHC class II mRNA expression.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	IK	IK	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	since	since	ADP	IN	_	_	_	_	_
16	over	over	ADP	IN	_	_	_	_	SpaceAfter=No
17	-expression	-expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
23	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
32	disappearance	disappearance	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
35	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
36	class	class	NOUN	NN	Number=Sing	_	_	_	_
37	II	ii	NUM	CD	NumType=Card	_	_	_	_
38	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6950
# text = The class II transactivator (CIITA) is necessary for both constitutive and IFN-gamma induced MHC class II expressions.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	expressions	expression	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6951
# text = Examination of CIITA mRNA in IK stably transfected clones revealed a marked reduction of CIITA mRNA transcription.
1	Examination	examination	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	IK	IK	PROPN	NNP	Number=Sing	_	_	_	_
7	stably	stably	ADV	RB	_	_	_	_	_
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
10	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
16	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6952
# text = Taken together these results demonstrate that the IK protein plays a key role in the constitutive expression of MHC class II antigens and that inhibition induced by IK is upstream of CIITA in this regulatory pathway.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IK	IK	PROPN	NNP	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	IK	IK	PROPN	NNP	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6953
# text = Document 003001925 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001925	003001925	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6954
# text = Epstein-Barr virus binding to CD21 activates the initial viral promoter via NF-kappaB induction.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	CD21	CD21	PROPN	NNP	Number=Sing	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6955
# text = Epstein-Barr virus (EBV), an oncogenic human herpesvirus, binds to and infects normal human B lymphocytes via CD21, the CR2 complement receptor.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	CD21	CD21	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	CR2	Cr2	NOUN	NN	Number=Sing	_	_	_	_
27	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6956
# text = Studies of the mechanisms that enable EBV to infect nonactivated, noncycling B cells provide compelling evidence for a sequence of events in which EBV binding to CD21 on purified resting human B cells rapidly activates the NF-kappaB transcription factor, which, in turn, binds to and mediates transcriptional activation of Wp, the initial viral latent gene promoter.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	enable	enable	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
10	nonactivated	nonactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	noncycling	noncycl	VERB	VBG	VerbForm=Ger	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	compelling	compelling	ADJ	JJ	Degree=Pos	_	_	_	_
17	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	events	event	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	CD21	CD21	PROPN	NNP	Number=Sing	_	_	_	_
29	on	on	ADV	RB	_	_	_	_	_
30	purified	purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	rapidly	rapidly	ADV	RB	_	_	_	_	_
36	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
54	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	Wp	Wp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
60	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
61	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
62	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
63	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6957
# text = Thus, EBV binding to its cellular receptor on resting B cells triggers an NF-kappaB-dependent intracellular signaling pathway which is required for infection.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	SCONJ	IN	_	_	_	_	_
10	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6958
# text = Document 003001926 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001926	003001926	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6959
# text = PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.
1	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	adipocyte	adipocyte	ADJ	JJ	Degree=Pos	_	_	_	_
9	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
10	acid	acid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6960
# text = The peroxisome-proliferator activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily of ligand activated transcription factors, plays a key role in the anti-diabetic actions of the thiazolidinediones (TZDs).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	peroxisome	peroxisome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	proliferator	proliferator	NOUN	NN	Number=Sing	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	member	member	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	superfamily	superfamily	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	anti-diabetic	anti-diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
32	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	thiazolidinediones	thiazolidinedione	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TZDs	Tzds	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6961
# text = PPARgamma induces the expression of many genes involved in lipid anabolism, including the adipocyte fatty acid binding protein (aP2), and is a key regulator of adipocyte differentiation.
1	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	_
2	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
11	anabolism	anabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	adipocyte	adipocyte	NOUN	NN	Number=Sing	_	_	_	_
16	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
17	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
18	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	aP2	ap2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	adipocyte	adipocyte	ADJ	JJ	Degree=Pos	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6962
# text = PPARgamma is also expressed in hematopoietic cells and is up-regulated in activated monocytes/macrophages.
1	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	macrophages.	macrophages.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6963
# text = Activation of PPARgamma may play a role in the induction of differentiation of macrophages to foam cells that are associated with atherosclerotic lesions.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	foam	foam	VERB	VB	VerbForm=Inf	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
23	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6964
# text = We report that both natural and synthetic PPARgamma agonists induce time- and dose-dependent increases in aP2 mRNA in both primary human monocytes and the monocytic cell line, THP-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
8	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	_
9	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
10	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	aP2	aP2	NUM	CD	NumType=Card	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6965
# text = These data suggest that PPARgamma activation may play a role in monocyte differentiation and function analogous to its well-characterized role in adipocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PPARgamma	PPARgamma	PROPN	NNP	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	_
16	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	adipocytes	adipocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6966
# text = Document 003001927 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001927	003001927	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6967
# text = An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	alpha/	alphaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
19	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
20	locus	locus	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6968
# text = T cell receptor (TCR) alpha and delta gene segments are organized within a single genetic locus but are differentially regulated during T cell development.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	organized	organize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
17	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
18	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	differentially	differentially	ADV	RB	_	_	_	_	_
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	during	during	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6969
# text = An enhancer-blocking element (BEAD-1, for blocking element alpha/delta 1) was localized to a 2.0-kb region 3' of TCR delta gene segments and 5' of TCR alpha joining gene segments within this locus.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	blocking	blocking	NOUN	NN	Number=Sing	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	BEAD	Bead	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	for	for	SCONJ	IN	_	_	_	_	_
12	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	alpha/	alpha/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	X	LS	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	2.0	2.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	'	'	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
30	delta	delta	PART	TO	Abbr=Yes	_	_	_	_
31	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	'	'	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	joining	join	VERB	VBG	VerbForm=Ger	_	_	_	_
40	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
41	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
42	within	within	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	locus.	locus.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 6970
# text = BEAD-1 blocked the ability of the TCR delta enhancer (Edelta) to activate a promoter when located between the two in a chromatin-integrated construct.
1	BEAD	Bead	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
10	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Edelta	Edelta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	two	two	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	chromatin-	chromatin-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6971
# text = We propose that BEAD-1 functions as a boundary that separates the TCR alpha/delta locus into distinct regulatory domains controlled by Edelta and the TCR alpha enhancer, and that it prevents Edelta from opening the chromatin of the TCR alpha joining gene segments for VDJ recombination at an early stage of T cell development.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	BEAD	Bead	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	boundary	boundary	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	separates	separate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
15	alpha/	alpha/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	delta	delof	PROPN	NNP	Number=Sing	_	_	_	_
17	locus	locus	ADV	RB	_	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
22	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	Edelta	Edelta	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
34	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	Edelta	Edelta	PROPN	NNP	Number=Sing	_	_	_	_
36	from	from	SCONJ	IN	_	_	_	_	_
37	opening	open	VERB	VBG	VerbForm=Ger	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
43	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
44	joining	join	VERB	VBG	VerbForm=Ger	_	_	_	_
45	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
46	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	VDJ	VDJ	PROPN	NNP	Number=Sing	_	_	_	_
49	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
50	at	at	ADP	IN	_	_	_	_	_
51	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
53	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	T	t	PROPN	NNP	Number=Sing	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6972
# text = Document 003001947 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001947	003001947	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6973
# text = Nuclear factor-kappaB induction in CD45RO+ and CD45RA+
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	CD45RO	CD45RO	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	+	+	SYM	SYM	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD45RA	CD45RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 6974
# text = T cell subsets during aging.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
4	during	during	ADP	IN	_	_	_	_	_
5	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6975
# text = An increase in the ratio of memory to naive T cells has been postulated to underlie immune hyporesponsiveness accompanying aging.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	naive	naive	VERB	VB	VerbForm=Inf	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
17	immune	immune	PRON	PRP	_	_	_	_	_
18	hyporesponsiveness	hyporesponsiveness	NOUN	NN	Number=Sing	_	_	_	_
19	accompanying	accompany	VERB	VBG	VerbForm=Ger	_	_	_	_
20	aging	ag	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6976
# text = Our analyses of the induction of nuclear factor-kappaB (NFkappaB) in activated memory (CD45RO+) and naive (CD45RA+)
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor-kappaB	factor-kappaB	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
14	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CD45RO	Cd45ro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	naive	naive	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CD45RA	CD45Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	+)	+)	SYM	NFP	_	_	_	_	_

# sent_id = 6977
# text = T cell subsets from young and elderly donors has demonstrated that, regardless of donor age, memory T cells are not significantly altered in their responsiveness to TNF-alpha-mediated induction of NFkappaB.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
8	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	regardless	regardless	ADV	RB	_	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	donor	donor	NOUN	NN	Number=Sing	_	_	_	_
16	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	significantly	significantly	ADV	RB	_	_	_	_	_
24	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha-mediated	alpha-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6978
# text = Although treatment with TNF-alpha induced nuclear localization of NFkappaB in both memory and naive T cell subsets, irrespective of the age of the donor, the levels of induced NFkappaB were significantly lower in both subsets of T cells obtained from the elderly, when compared to those in young.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	irrespective	irrespective	ADJ	JJ	Degree=Pos	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	age	age	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	donor	donor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	significantly	significantly	ADV	RB	_	_	_	_	_
36	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	both	both	DET	DT	_	_	_	_	_
39	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	T	t	PROPN	NNP	Number=Sing	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
43	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	from	from	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	when	when	ADV	WRB	PronType=Int	_	_	_	_
49	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	young	young	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6979
# text = Examination of IkappaB alpha regulation revealed that TNF-alpha-mediated degradation of IkappaB alpha in both memory and naive T cells from the elderly was severely impaired, thus contributing to the lowered induction of the observed NFkappaB.
1	Examination	examination	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha-mediated	alpha-mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	_
14	alpha	alpha	ADV	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	elderly	elderly	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	severely	severely	ADV	RB	_	_	_	_	_
27	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	thus	thus	ADV	RB	_	_	_	_	_
30	contributing	contribute	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	lowered	lower	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	_
38	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6980
# text = In addition, this age-related decrease in induction of nuclear NFkappaB correlated with decrease in intracellular IL-2 receptor expression and anti-CD3-induced proliferation of both memory and naive T cells subsets.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
8	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
14	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
27	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	both	both	CCONJ	CC	_	_	_	_	_
30	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	subsets	subset	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6981
# text = Taken together, our results suggest that the age-related hyporesponsiveness cannot be attributed to a skewing of the T cell population towards a memory phenotype in the elderly.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
12	hyporesponsiveness	hyporesponsiveness	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
14	not	not	PART	RB	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	skewing	skewing	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	population	population	NOUN	NN	Number=Sing	_	_	_	_
25	towards	towards	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
28	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	elderly	elderly	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6982
# text = Document 003001949 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001949	003001949	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6983
# text = Patterns of Pan expression and role of Pan proteins in endocrine cell type-specific complex formation.
1	Patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
17	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6984
# text = The Pan gene encodes at least two distinct transcripts, Pan-1 and Pan-2 (also known as E47 and E12, respectively), by the mechanism of alternative RNA splicing.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	at	at	ADV	RB	_	_	_	_	_
6	least	least	ADV	RBS	Degree=Sup	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	also	also	ADV	RB	_	_	_	_	_
20	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	E47	E47	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	E12	E12	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
34	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
35	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6985
# text = Northern blot analyses performed on rat and mouse tissues have detected ubiquitously expressed Pan transcripts, but the abundance, distribution, and form of Pan proteins have not been clearly defined.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	_
15	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	form	form	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
28	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	clearly	clearly	ADV	RB	_	_	_	_	_
32	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6986
# text = Studies of cell lines representing endocrine, fibroblast, and lymphoid lineages using polyclonal antisera to detect E2A proteins have suggested that significant E2A protein expression is restricted to B-lymphocytes.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
6	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	fibroblast	fibroblast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
15	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
18	E2A	E2a	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
24	E2A	E2a	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6987
# text = We have developed a monoclonal antibody, Yae, which is specific for Pan/E2A proteins, and have used the Yae antibody to examine a variety of endocrine and nonendocrine cell lineages for differences in Pan/E2A protein expression, subcellular localization, and heteromeric complex formation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Yae	Yae	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	Pan/	Pan/	SYM	SYM	_	_	_	_	SpaceAfter=No
15	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	A	a	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Yae	Yae	PROPN	NNP	Number=Sing	_	_	_	_
24	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	nonendocrine	nonendocrine	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	Pan/	Pan/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	E2	E2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	subcellular	subcelular	ADJ	JJ	Degree=Pos	_	_	_	_
45	localization	localization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	heteromeric	heteromeric	ADJ	JJ	Degree=Pos	_	_	_	_
49	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
50	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6988
# text = In contrast to previous results obtained using polyclonal antiseras to detect Pan/E2A proteins, we report comparable levels of Pan proteins in GH/PRL- and insulin-producing, B- and T-lymphocyte cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antiseras	antisera	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
12	Pan/	Pan/	SYM	SYM	_	_	_	_	SpaceAfter=No
13	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	A	a	NOUN	NN	Number=Sing	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	GH	GH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	PRL	PRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	insulin-	insulin-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6989
# text = IEF-1, a pancreatic beta-cell type-specific complex believed to regulate insulin expression, is demonstrated to consist of at least two distinct species, one of which does not contain Pan molecules.
1	IEF	IEF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	insulin	insulin	ADP	IN	_	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	consist	consist	VERB	VB	VerbForm=Inf	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	at	at	ADV	RB	_	_	_	_	_
26	least	least	ADV	RBS	Degree=Sup	_	_	_	_
27	two	two	NUM	CD	NumType=Card	_	_	_	_
28	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
29	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	one	one	NUM	CD	NumType=Card	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Int	_	_	_	_
34	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
37	Pan	Pan	PROPN	NNP	Number=Sing	_	_	_	_
38	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6990
# text = Although it has been postulated that pituitary endocrine cells and pancreatic endocrine beta-cells share identical Pan/E2A complexes, native-Western analyses of pituitary and endocrine beta-cells detect Pan proteins in distinct cell type-specific complexes.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	pituitary	pituitary	ADJ	JJ	Degree=Pos	_	_	_	_
8	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
12	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
18	Pan/E2	Pan/E2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	A	a	NOUN	NN	Number=Sing	_	_	_	_
20	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	native	native	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
25	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	detect	detect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	Pan	Pan	ADJ	JJ	Degree=Pos	_	_	_	_
35	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
42	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 6991
# text = Document 003001953 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001953	003001953	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 6992
# text = Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation.
1	Coupling	Coupling	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
10	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 6993
# text = The eukaryotic transcription factor NF-kappa B plays a central role in the induced expression of human immunodeficiency virus type 1 and in many aspects of the genetic program mediating normal T-cell activation and growth.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
26	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
30	program	program	NOUN	NN	Number=Sing	_	_	_	_
31	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
32	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
33	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6994
# text = The nuclear activity of NF-kappa B is tightly regulated from the cytoplasmic compartment by an inhibitory subunit called I kappa B alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	tightly	tightly	ADV	RB	_	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
19	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
20	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6995
# text = This cytoplasmic inhibitor is rapidly phosphorylated and degraded in response to a diverse set of NF-kappa B-inducing agents, including T-cell mitogens, proinflammatory cytokines, and viral transactivators such as the Tax protein of human T-cell leukemia virus type 1.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	rapidly	rapidly	ADV	RB	_	_	_	_	_
6	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
14	set	set	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
34	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
35	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
45	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
46	type	type	NOUN	NN	Number=Sing	_	_	_	_
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6996
# text = To explore these I kappa B alpha-dependent mechanisms for NF-kappa B induction, we identified novel mutants of I kappa B alpha that uncouple its inhibitory and signal-transducing functions in human T lymphocytes.
1	To	to	PART	TO	_	_	_	_	_
2	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
21	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	B	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	ADP	IN	_	_	_	_	_
27	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	uncouple	uncouple	NOUN	NN	Number=Sing	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	transducing	transducing	VERB	VBG	VerbForm=Ger	_	_	_	_
35	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6997
# text = Specifically, removal of the N-terminal 36 amino acids of I kappa B alpha failed to disrupt its ability to form latent complexes with NF-kappa B in the cytoplasm.
1	Specifically	specifically	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	36	36	NUM	CD	NumType=Card	_	_	_	_
9	amino	amino	DET	DT	_	_	_	_	_
10	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	B	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
16	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
23	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
24	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6998
# text = However, this deletion mutation prevented the induced phosphorylation, degradative loss, and functional release of I kappa B alpha from NF-kappa B in Tax-expressing cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	degradative	degradative	ADJ	JJ	Degree=Pos	_	_	_	_
12	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
16	release	release	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6999
# text = Alanine substitutions introduced at two serine residues positioned within this N-terminal regulatory region of I kappa B alpha also yielded constitutive repressors that escaped from Tax-induced turnover and that potently inhibited immune activation pathways for NF-kappa B induction, including those initiated from antigen and cytokine receptors.
1	Alanine	Alanine	NUM	CD	NumType=Card	_	_	_	_
2	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
3	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
7	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
8	positioned	position	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	yielded	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	escaped	escape	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	potently	potently	ADV	RB	_	_	_	_	_
34	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
46	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
47	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	from	from	ADP	IN	_	_	_	_	_
49	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
52	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7000
# text = In contrast, introduction of a phosphoserine mimetic at these sites rectified this functional defect, a finding consistent with a causal linkage between the phosphorylation status and proteolytic stability of this cytoplasmic inhibitor.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	phosphoserine	phosphoserine	NOUN	NN	Number=Sing	_	_	_	_
8	mimetic	mimetic	ADJ	JJ	Degree=Pos	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	rectified	rectify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	defect	defect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
19	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	causal	causal	ADJ	JJ	Degree=Pos	_	_	_	_
23	linkage	linkage	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
27	status	status	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
34	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7001
# text = Together, these in vivo studies define a critical signal response domain in I kappa B alpha that coordinately controls the biologic activities of I kappa B alpha and NF-kappa B in response to viral and immune stimuli.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	I	I	PROPN	NNP	Number=Sing	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	ADP	IN	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	coordinately	coordinately	ADV	RB	_	_	_	_	_
20	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
23	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
40	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7002
# text = Document 003001956 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001956	003001956	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7003
# text = Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
8	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7004
# text = Transcription factors of the NFAT (nuclear factor of activated T cells) family play important roles in immune and inflammatory responses by regulating the expression of genes encoding cytokines and immunoregulatory proteins.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
29	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
30	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7005
# text = Here we describe cloning and characterization of full-length cDNA encoding murine (m) NFATc which predicts that the protein has all the conserved structural motifs of NFAT family members, including the rel homology domain, the NFAT homology domain and the nuclear translocation signals.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	length	length	NOUN	NN	Number=Sing	_	_	_	_
11	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
12	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
13	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	m	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	predicts	predict	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	all	all	DET	PDT	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	conserved	conserved	ADJ	JJ	Degree=Pos	_	_	_	_
27	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
28	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
31	family	family	NOUN	NN	Number=Sing	_	_	_	_
32	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
37	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
38	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
42	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
43	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
47	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
48	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7006
# text = mNFATc complexed with AP-1 bound specifically to the murine IL-2 NFAT recognition sequence and activated transcription from the co-transfected IL-2 promoter in COS-7 cells.
1	mNFATc	mnfatc	NOUN	NN	Number=Sing	_	_	_	_
2	complexed	complex	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	bound	bound	NOUN	NN	Number=Sing	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
16	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7007
# text = Northern blot analysis showed that the cDNA probe hybridized with a 4.5 kb transcript which is highly inducible in murine T cells.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
8	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
9	hybridized	hybridize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	4.5	4.5	NUM	CD	NumType=Card	_	_	_	_
13	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
14	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	highly	highly	ADV	RB	_	_	_	_	_
18	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7008
# text = By Northern and in situ hybridization, mNFATc transcript was detected from the early stage of development.
1	By	by	ADP	IN	_	_	_	_	_
2	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
6	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	mNFATc	mNFATc	PROPN	NNP	Number=Sing	_	_	_	_
9	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
15	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7009
# text = In the mouse embryo, mNFATc transcript was strongly expressed in thymus, lung and submandibular gland and weakly in skeletal muscle and heart suggesting that mNFATc may have a role both in embryogenesis and in mature T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	embryo	embryo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	mNFATc	mNFATc	PROPN	NNP	Number=Sing	_	_	_	_
7	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	strongly	strongly	ADV	RB	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	submandibular	submandibular	ADJ	JJ	Degree=Pos	_	_	_	_
17	gland	gland	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	weakly	weakly	ADV	RB	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	skeletal	skeletal	ADJ	JJ	Degree=Pos	_	_	_	_
22	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	heart	heart	NOUN	NN	Number=Sing	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	mNFATc	mNFATc	PROPN	NNP	Number=Sing	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	both	both	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	embryogenesis	embryogenesis	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7010
# text = Document 003001957 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001957	003001957	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7011
# text = Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transmission	transmission	NOUN	NN	Number=Sing	_	_	_	_
5	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
13	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	immunophilin	immunophilin	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	either	either	CCONJ	CC	_	_	_	_	_
19	FK506	Fk506	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7012
# text = Proliferation and immunologic function of T lymphocytes are initiated by signals from the antigen receptor that are inhibited by the immunosuppressant FK506 but not by its structural analog, rapamycin.
1	Proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
22	FK506	Fk506	NOUN	NN	Number=Sing	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
28	analog	analog	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7013
# text = On the other hand, interleukin 2 (IL-2)-induced signals are blocked by rapamycin but not by FK506.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7014
# text = Remarkably, these two drugs inhibit each other's actions, raising the possibility that both act by means of a common immunophilin (immunosuppressant binding protein).
1	Remarkably	remarkably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
6	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	each	each	DET	DT	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	's	's	PART	POS	_	_	_	_	_
10	actions	action	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	raising	rais	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	act	act	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	means	means	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunophilin	immunophilin	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7015
# text = We find that the dissociation constant of rapamycin to the FK506 binding protein FKBP (Kd = 0.2 nM) is close to the dissociation constant of FK506 to FKBP (Kd = 0.4 nM) and to their effective biologic inhibitory concentrations.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
6	constant	constant	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	FK506	Fk506	NOUN	NN	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	FKBP	FKBP	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Kd	K	PROPN	NNP	Number=Sing	_	_	_	_
17	=	=	SYM	SYM	_	_	_	_	_
18	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
19	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
26	constant	constant	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	FKBP	FKBP	PROPN	NNP	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Kd	K	PROPN	NNP	Number=Sing	_	_	_	_
33	=	=	SYM	SYM	_	_	_	_	_
34	0.4	0.4	NUM	CD	NumType=Card	_	_	_	_
35	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
41	biologic	biologic	NOUN	NN	Number=Sing	_	_	_	_
42	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
43	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7016
# text = However, an excess of rapamycin is needed to revert FK506-mediated inhibition of IL-2 production, apoptosis, and transcriptional activation of NF-AT, a T-cell-specific transcription factor necessary for IL-2 gene activation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	excess	excess	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
11	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7017
# text = Similarly, an excess of FK506 is needed to revert rapamycin-mediated inhibition of IL-2-induced proliferation.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	excess	excess	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
11	rapamycin-	rapamycin-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7018
# text = The drug concentrations required for antagonism may be explained by the relative affinity of the drugs to, and by the abundance of, the immunophilin FKBP.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
13	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	immunophilin	immunophilin	ADJ	JJ	Degree=Pos	_	_	_	_
27	FKBP	Fkbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7019
# text = FKBP has been shown to catalyze the interconversion of the cis- and trans-rotamers of the peptidyl-prolyl amide bond of peptide substrates; here we show that rapamycin, like FK506, is a potent inhibitor of the rotamase activity of FKBP
1	FKBP	FKBP	SYM	NFP	_	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	catalyze	catalyze	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interconversion	interconversion	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	rotamers	rotamer	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	peptidyl	peptidyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	prolyl	prolyl	NOUN	NN	Number=Sing	_	_	_	_
22	amide	amide	NOUN	NN	Number=Sing	_	_	_	_
23	bond	bond	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
26	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	here	here	ADV	RB	PronType=Dem	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	like	like	ADP	IN	_	_	_	_	_
35	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
40	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	rotamase	rotamase	NOUN	NN	Number=Sing	_	_	_	_
44	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	FKBP	FKBP	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 7020
# text = (Ki = 0.2 nM).
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ki	Ki	PROPN	NNP	Number=Sing	_	_	_	_
3	=	=	SYM	SYM	_	_	_	_	_
4	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
5	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7021
# text = Neither FKBP binding nor inhibition of rotamase activity of FKBP alone is sufficient to explain the biologic actions of these drugs.
1	Neither	neither	DET	DT	_	_	_	_	_
2	FKBP	Fkbp	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	nor	nor	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	rotamase	rotamase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FKBP	FKBP	PROPN	NNP	Number=Sing	_	_	_	_
11	alone	alone	ADV	RB	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
18	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7022
# text = Rather, these findings suggest that immunophilin bound to FK506 interferes with antigen receptor-induced signals, while rapamycin bound to the immunophilin interferes with IL-2-induced signals.
1	Rather	Rather	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	immunophilin	immunophilin	ADJ	JJ	Degree=Pos	_	_	_	_
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
11	interferes	interfere	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	immunophilin	immunophilin	NOUN	NN	Number=Sing	_	_	_	_
25	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7023
# text = Document 003001966 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001966	003001966	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7024
# text = Signals transduced through the CD4 molecule on T lymphocytes activate NF-kappa B.
1	Signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
2	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7025
# text = We have demonstrated that native envelope glycoproteins of HIV-1, gp160 can induce activation of the transcription factor, NF-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
6	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
7	glycoproteins	glycoprotein	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	gp160	gp160	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7026
# text = The stimulatory effects of gp160 are mediated through the CD4 molecule, since pretreatment with soluble CD4 abrogates its activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	gp160	gp160	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
11	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	SCONJ	IN	_	_	_	_	_
14	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
18	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7027
# text = The gp160-induced NF-kappa B complex consists of p65, p50 and c-rel proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gp160	gp160	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
9	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	p50	p50	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7028
# text = The stimulatory effect of gp160 on NF-kappa B activation is protein synthesis independent, is dependent upon protein tyrosine phosphorylation, and abrogated by inhibitors of protein kinase C.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	upon	upon	ADP	IN	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7029
# text = The gp160-mediated activation of NF-kappa B in CD4 positive T cells may be involved in biological effects, e.g., enhanced HIV replication, hypergammaglobulinemia, increased cytokine secretion, hypercellularity in bone marrow and apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gp160	gp160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
13	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
27	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	hypergammaglobulinemia	hypergammaglobulinemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	hypercellularity	hypercellularity	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
38	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7030
# text = Document 003001967 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001967	003001967	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7031
# text = Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7032
# text = HTLV-1 infection causes an adult T cell leukemia in humans.
1	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
5	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7033
# text = The viral encoded protein tax, is thought to play an important role in oncogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	oncogenesis	oncogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7034
# text = Our previous data obtained from a tax transgenic mouse model revealed that tax transforms mouse fibroblasts but not thymocytes, despite comparable levels of tax expression in both tissues.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	transgenic	transgenic	NOUN	NN	Number=Sing	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	model	model	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
14	transforms	transform	NOUN	NNS	Number=Plur	_	_	_	_
15	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
16	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	despite	despite	ADP	IN	_	_	_	_	_
22	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7035
# text = Constitutive tyrosine phosphorylation of a 130-kD protein(s) was observed in the tax transformed fibroblast B line and in HTLV-1 transformed human lymphoid lines, but not in thymocytes from Thy-tax transgenic mice.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	130	130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	s	s	X	AFX	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
18	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
30	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	not	not	ADV	RB	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	Thy	thy	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
40	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
41	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7036
# text = Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies, identified p130 as Jak2 in the tax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines.
1	Phosphotyrosine	Phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
3	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
6	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	set	set	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	p130	p130	NUM	CD	NumType=Card	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
24	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
26	fibroblastic	fibroblastic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7037
# text = Phosphorylation of Jak2 in tax transformed cells resulted from high expression of IL-6.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7038
# text = Tyrosine phosphorylation of this protein could also be induced in Balb/c3T3 cells using a supernatant from the B line, which was associated with induction of cell proliferation.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Balb/	Balb/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	c3T3	c3T3	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7039
# text = Both phosphorylation and proliferation were inhibited by IL-6 neutralizing antibodies.
1	Both	both	DET	DT	_	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7040
# text = Constitutive phosphorylation of Jak kinases may facilitate tumor growth in both HTLV-1 infected human T cells and the transgenic mouse model.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
5	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
22	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
23	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7041
# text = Document 003001968 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001968	003001968	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7042
# text = Regulation of interleukin-1 beta production by glucocorticoids in human monocytes:
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 7043
# text = the mechanism of action depends on the activation signal.
1	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7044
# text = Glucocorticoids are known to downregulate interleukin-1 beta production in monocytic cells by two different mechanims: direct inhibition of the gene transcription and destabilization of the preformed interleukin-1 beta mRNA.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	downregulate	downregulate	VERB	VB	VerbForm=Inf	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanims	mechanim	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	destabilization	destabilization	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	preformed	preform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7045
# text = Now we have examined the effect of the nature of the monocyte activating signal on these two inhibitory mechanims.
1	Now	now	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
13	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanims	mechanim	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7046
# text = When human monocytes were preincubated with dexamethasone for 1 hour and then stimulated either with bacterial lipopolysaccharide or phorbol myristate, it was found that dexamethasone inhibited the lipopolysaccharide-induced interleukin-1 beta protein production, but the phorbol myristate-induced production was increased 3-10 fold.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	then	then	ADV	RB	PronType=Dem	_	_	_	_
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	dexamethasone	dexamethasone	PRON	NN	Number=Sing	_	_	_	_
27	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
42	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	production	production	NOUN	NN	Number=Sing	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	10	10	NUM	CD	NumType=Card	_	_	_	_
51	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7047
# text = This difference was also seen at the mRNA level.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7048
# text = When dexamethasone was added to the cultures 3 hours after the stimulators, it clearly decreased the interleukin-1 beta mRNA levels regardless of the stimulator used (although the effect was clearly weaker on the PMA-induced mRNA).
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	dexamethasone	dexamethasone	PRON	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	stimulators	stimulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	clearly	clearly	ADV	RB	_	_	_	_	_
16	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	mRNA	mRNa	SYM	SYM	_	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	regardless	regardless	ADV	RB	_	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	stimulator	stimulator	NOUN	NN	Number=Sing	_	_	_	_
28	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	although	although	SCONJ	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	clearly	clearly	ADV	RB	_	_	_	_	_
35	weaker	weaker	ADJ	JJR	Degree=Cmp	_	_	_	_
36	on	on	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7049
# text = Thus these data suggest that the phorbol myristate-induced signal (prolonged protein kinase C activation?) cannot be inhibited by prior incubation with dexamethasone and it also protects the induced mRNA for the degradative action of dexamethasone.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	?	?	PUNCT	.	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
21	not	not	PART	RB	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
26	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
31	also	also	ADV	RB	_	_	_	_	_
32	protects	protect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	degradative	degradative	ADJ	JJ	Degree=Pos	_	_	_	_
39	action	action	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7050
# text = Document 003001970 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001970	003001970	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7051
# text = Heat shock induces HIV-1 replication in chronically infected promyelocyte cell line OM10.1.
1	Heat	heat	ADJ	JJ	Degree=Pos	_	_	_	_
2	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	chronically	chronically	ADV	RB	_	_	_	_	_
10	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	_
14	OM	Om	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	10.1	10.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7052
# text = A long period of clinical latency before development of symptoms is characteristic of human immunodeficiency virus type 1 (HIV-1) infection.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
3	period	period	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
6	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
7	before	before	ADP	IN	_	_	_	_	_
8	development	development	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7053
# text = OM10.1, a promyelocyte cell line latently infected with HIV-1, has been developed as a model for studying the mechanism of viral latency and the activation of virus expression.
1	OM	Om	ADP	IN	_	_	_	_	SpaceAfter=No
2	10.1	10.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	promyelocyte	promyelocyte	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	latently	latently	ADV	RB	_	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	model	model	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	SCONJ	IN	_	_	_	_	_
22	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7054
# text = We found that this latently infected cell line with heat shock at 42 degrees C for 2 h resulted in a high level of HIV-1 production without addition of any cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	latently	latently	ADV	RB	_	_	_	_	_
6	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
11	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	42	42	NUM	CD	NumType=Card	_	_	_	_
14	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
15	C	C	PROPN	NNP	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	_
19	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	without	without	ADP	IN	_	_	_	_	_
30	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	any	any	DET	DT	_	_	_	_	_
33	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7055
# text = The mechanism of activation was analyzed by using anti-TNF-alpha antibody and various inhibitors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7056
# text = Although the TNF-alpha level in culture supernatants was below the sensitivity of an ELISA assay system, addition of anti-TNF-alpha antibody in culture medium could partially suppress the heat shock induced HIV-1 production.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
9	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	below	below	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
17	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
18	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
28	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
29	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
30	partially	partially	ADV	RB	_	_	_	_	_
31	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
34	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7057
# text = Staurosporine (PKC inhibitor), pentoxifylline (NF-kappa B inhibitor), and Ro5-3335 (HIV-1
1	Staurosporine	Staurosporine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
4	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	pentoxifylline	pentoxifylline	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Ro5-3335	Ro5-3335	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 7058
# text = Tat inhibitor) also inhibited significantly the heat shock induced virus activation.
1	Tat	Tat	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	significantly	significantly	ADV	RB	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
9	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7059
# text = In particular, staurosporine achieved approximately 90% inhibition of the HIV-1 antigen expression in heat shock-treated OM10.1 at a non-toxic concentration.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	staurosporine	staurosporine	PRON	PRP	_	_	_	_	_
5	achieved	achieve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	approximately	approximately	ADV	RB	_	_	_	_	_
7	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	%	%	SYM	NN	Number=Sing	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
19	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	OM10.1	Om10.1	NUM	CD	NumType=Card	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	non-toxic	non-toxic	ADJ	JJ	Degree=Pos	_	_	_	_
26	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7060
# text = Although the mechanism of HIV-1 activation with heat shock has not been fully elucidated yet, it is presumed PKC plays an important role in HIV-1 activation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
11	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	fully	fully	ADV	RB	_	_	_	_	_
16	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	yet	yet	ADV	RB	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	PKC	Pkc	PROPN	NNP	Number=Sing	_	_	_	_
23	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7061
# text = Thus, the present observations will provide a further insight into the pathogenesis of HIV-1 infections.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
6	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
7	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
10	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7062
# text = Document 003001975 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001975	003001975	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7063
# text = SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.
1	SHP2	SHP2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
4	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
5	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	SIT	Sit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
13	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
17	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7064
# text = T lymphocytes express several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling motifs.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
8	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
9	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	recruit	recruit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	src	src	ADJ	JJ	Degree=Pos	_	_	_	_
14	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	SH	SH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
22	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
28	via	via	ADP	IN	_	_	_	_	_
29	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
33	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7065
# text = We describe here a novel molecule of this group termed SIT (SHP2 interacting transmembrane adaptor protein).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	group	group	NOUN	NN	Number=Sing	_	_	_	_
10	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	SIT	sit	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	SHP2	Shp2	NUM	CD	NumType=Card	_	_	_	_
14	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
15	transmembrane	transmembrane	ADJ	JJ	Degree=Pos	_	_	_	_
16	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7066
# text = SIT is a disulfide-linked homodimeric glycoprotein that is expressed in lymphocytes.
1	SIT	sit	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	homodimeric	homodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
8	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7067
# text = After tyrosine phosphorylation by src and possibly syk protein tyrosine kinases SIT recruits the SH2 domain-containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif.
1	After	after	ADP	IN	_	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	src	src	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	possibly	possibly	ADV	RB	_	_	_	_	_
8	syk	syk	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
11	kinases	kinase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	SIT	Sit	PROPN	NNP	Number=Sing	_	_	_	_
13	recruits	recruit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
21	SHP2	SHP2	NUM	CD	NumType=Card	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	immunoreceptor	immunoreceptor	ADJ	JJ	Degree=Pos	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
29	motif.	motif.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7068
# text = Overexpression of SIT in Jurkat cells downmodulates T cell receptor- and phytohemagglutinin-mediated activation of the nuclear factor of activated T cells (NF-AT) by interfering with signaling processes that are probably located upstream of activation of phospholipase C.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	SIT	Sit	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	downmodulates	downmodulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	T	t	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	phytohemagglutinin-	phytohemagglutinin-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
33	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	probably	probably	ADV	RB	_	_	_	_	_
37	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
43	C	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7069
# text = However, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	SHP2	SHP2	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	SIT	Sit	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	AT	at	ADP	IN	_	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	SIT	Sit	PROPN	NNP	Number=Sing	_	_	_	_
22	not	not	ADV	RB	_	_	_	_	_
23	only	only	ADV	RB	_	_	_	_	_
24	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	also	also	ADV	RB	_	_	_	_	_
31	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	AT	at	ADP	IN	_	_	_	_	_
35	unrelated	unrelated	ADJ	JJ	Degree=Pos	_	_	_	_
36	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
42	SHP2	Shp2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7070
# text = Document 003001977 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001977	003001977	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7071
# text = Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B.
1	Thiol	Thiol	ADJ	JJ	Degree=Pos	_	_	_	_
2	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7072
# text = The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1RI	1RI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	thus	thus	ADV	RB	_	_	_	_	_
19	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
31	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7073
# text = The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al.,
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	initiating	initiating	NOUN	NN	Number=Sing	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	still	still	ADV	RB	_	_	_	_	_
6	uncertain	uncertain	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	_
25	detectable	detectable	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	Martin	Martin	PROPN	NNP	Number=Sing	_	_	_	_
28	et	et	X	FW	_	_	_	_	_
29	al.	al.	X	FW	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 7074
# text = Eur.J.Immunol.1994.24: 1566).
1	Eur.J.Immunol	Eur.J.Immunol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	.1994.24	.1994.24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_
4	1566	1566	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7075
# text = IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	commonly	commonly	ADV	RB	_	_	_	_	_
7	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
10	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	redox	redox	VERB	VB	VerbForm=Inf	_	_	_	_
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7076
# text = We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1RI	1RI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	target	target	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	whether	whether	SCONJ	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	altered	alter	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
32	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	NOUN	NN	Number=Sing	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7077
# text = A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	T	t	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	EL4	EL4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	without	without	ADP	IN	_	_	_	_	_
18	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
22	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
28	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7078
# text = Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase.
1	Thiol	Thiol	NOUN	NN	Number=Sing	_	_	_	_
2	modifying	modify	VERB	VBG	VerbForm=Ger	_	_	_	_
3	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
4	like	like	ADP	IN	_	_	_	_	_
5	diamide	diamide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	menadione	menadione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
10	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	diethyl	diethyl	ADJ	JJ	Degree=Pos	_	_	_	_
16	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	phenylarsine	phenylarsine	NOUN	NN	Number=Sing	_	_	_	_
19	oxide	oxide	ADV	RB	_	_	_	_	_
20	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1RI	1RI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7079
# text = N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect.
1	N	not	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Acetylcysteine	Acetylcysteine	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
7	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
8	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
9	dipyridyl	dipyridyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	aminotriazole	aminotriazole	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	nitrofurantoin	nitrofurantoin	NOUN	NN	Number=Sing	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
17	any	any	DET	DT	_	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7080
# text = The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
7	unless	unless	SCONJ	IN	_	_	_	_	_
8	glutathione	glutathione	ADJ	JJ	Degree=Pos	_	_	_	_
9	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	buthionine	buthionine	NUM	CD	NumType=Card	_	_	_	_
14	sulfoximine	sulfoximine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7081
# text = The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1RI	1RI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	similarly	similarly	ADV	RB	_	_	_	_	_
19	impaired	impaire	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	EL4	EL4	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7082
# text = From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
8	thiols	thiol	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1RI	1ri	NOUN	NN	Number=Sing	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1RI	1RI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	process	process	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	mandatory	mandatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
40	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7083
# text = Document 003001988 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001988	003001988	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7084
# text = Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: a study with allergen-specific human helper T cells.
1	Cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
12	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	study	study	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	allergen	allergen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7085
# text = BACKGROUND: Cytokines produced by helper T cells are intimately involved in chronic allergic diseases associated with eosinophilic inflammation.
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Cytokines	Cytokine	NOUN	NNS	Number=Plur	_	_	_	_
4	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	intimately	intimately	ADV	RB	_	_	_	_	_
11	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
14	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
15	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
19	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7086
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 7087
# text = We investigated the production of IL-5, a potent growth factor and chemotactic factor for eosinophils, by CD4+ T lymphocytes in patients with asthma.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	T	t	NUM	CD	NumType=Card	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7088
# text = METHODS: Allergen-specific
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Allergen	Allergen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 7089
# text = T cell clones and T cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the responses to various stimuli were determined.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
7	hybridomas	hybridoma	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	determined	determin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7090
# text = RESULTS: After nonspecific stimulation, IL-5 production by CD4+ T cells from both atopic and nonatopic subjects with asthma was significantly enhanced compared with that by cells from healthy controls.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	After	after	ADP	IN	_	_	_	_	_
4	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	5	5	NUM	CD	NumType=Card	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	T	t	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	nonatopic	nonatopic	ADJ	JJ	Degree=Pos	_	_	_	_
21	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
34	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7091
# text = Peripheral blood mononuclear cells from atopic asthma patients both proliferated and produced IL-5 after incubation with mite allergen, suggesting that mite-specific helper T cells were involved in the eosinophilic inflammation of atopic asthma.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
7	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	proliferated	proliferate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	5	5	NUM	CD	NumType=Card	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	mite	mite	NOUN	NN	Number=Sing	_	_	_	_
20	allergen	allergen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	mite	mite	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
35	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
38	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7092
# text = A human IL-5 promoter/enhancer luciferase gene construct transfected into IL-5-producing T cell clones was clearly transcribed after stimulation, indicating that the 515 base pair IL-5 gene segment upstream of the coding region was sufficient to respond to activating signals in human helper T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	clearly	clearly	ADV	RB	_	_	_	_	_
24	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	after	after	ADP	IN	_	_	_	_	_
26	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	515	515	NUM	CD	NumType=Card	_	_	_	_
32	base	base	NOUN	NN	Number=Sing	_	_	_	_
33	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
34	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	5	5	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
39	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
43	region	region	NOUN	NN	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
46	to	to	PART	TO	_	_	_	_	_
47	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
50	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
53	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7093
# text = The same gene segment was not transcribed in IL-5-nonproducing T cell clones, suggesting that human T cell IL-5 synthesis is regulated at the transcriptional level.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	nonproducing	nonproduce	VERB	VBG	VerbForm=Ger	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7094
# text = Experiments with T cell hybridomas confirmed these findings and suggested that a unique transcription factor may be essential for human IL-5 gene transcription.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
5	hybridomas	hybridoma	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7095
# text = CONCLUSION: Enhanced IL-5 production by helper T cells seems to cause the eosinophilic inflammation of both atopic and nonatopic asthma.
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Enhanced	enhance	PROPN	NNP	Number=Sing	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
17	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	nonatopic	nonatopic	ADJ	JJ	Degree=Pos	_	_	_	_
23	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7096
# text = Elucidation of IL-5-specific regulatory mechanisms may facilitate the development of novel treatments for allergic diseases associated with eosinophilic inflammation.
1	Elucidation	Elucidation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
16	treatments	treatment	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
19	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
23	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7097
# text = Document 003001990 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003001990	003001990	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7098
# text = Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells.
1	Renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	gangliosides	ganglioside	NOUN	NNS	Number=Plur	_	_	_	_
7	suppress	suppress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor-kappaB	factor-kappab	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7099
# text = Activation of the transcription factor nuclear factor-kappaB (NFkappaB) is impaired in T cells from patients with renal cell carcinomas (RCCs).
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	RCCs	RCC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7100
# text = In circulating T cells from a subset of patients with RCCs, the suppression of NFkappaB binding activity is downstream from the stimulus-induced degradation of the cytoplasmic factor IkappaBalpha.
1	In	in	SCONJ	IN	_	_	_	_	_
2	circulating	circulat	VERB	VBG	VerbForm=Ger	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	RCCs	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7101
# text = Tumor-derived soluble products from cultured RCC explants inhibit NFkappaB activity in T cells from healthy volunteers, despite a normal level of stimulus-induced IkappaBalpha degradation in these cells.
1	Tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
5	products	product	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
8	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
9	explants	explant	NOUN	NNS	Number=Plur	_	_	_	_
10	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	NFkappaB	Nfkappab	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
18	volunteers	volunteer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	despite	despite	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
29	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7102
# text = The inhibitory agent has several features characteristic of a ganglioside, including sensitivity to neuraminidase but not protease treatment; hydrophobicity; and molecular weight less than 3 kDa.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
7	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	ganglioside	ganglioside	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	neuraminidase	neuraminidase	NOUN	NN	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	protease	protease	VERB	VB	VerbForm=Inf	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	hydrophobicity	hydrophobicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
25	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
26	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
27	than	than	ADP	IN	_	_	_	_	_
28	3	3	NUM	CD	NumType=Card	_	_	_	_
29	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7103
# text = Indeed, we detected gangliosides in supernatants from RCC explants and not from adjacent normal kidney tissue.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	gangliosides	ganglioside	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
10	explants	explant	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
17	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7104
# text = Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.
1	Gangliosides	Gangliosides	NOUN	NNS	Number=Plur	_	_	_	_
2	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
5	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
13	gangliosides	ganglioside	NOUN	NNS	Number=Plur	_	_	_	_
14	G(	G(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	m1	m1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	G	G	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	d1a	d1a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
25	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	T	T	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7105
# text = Taken together, our findings suggest that tumor-derived gangliosides may blunt antitumor immune responses in patients with RCCs.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gangliosides	ganglioside	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	blunt	blunt	VERB	VB	VerbForm=Inf	_	_	_	_
14	antitumor	antitumor	ADP	IN	_	_	_	_	_
15	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
16	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	RCCs	RCC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7106
# text = Document 0030011000 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011000	0030011000	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7107
# text = 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation.
1	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	deazaadenosine	deazaadenosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	S-	S-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	adenosylhomocysteine	adenosylhomocysteine	NOUN	NN	Number=Sing	_	_	_	_
8	hydrolase	hydrolase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
13	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7108
# text = Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	promotion	promotion	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
12	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7109
# text = Previously we reported that 3-deazaadenosine (DZA), a potent inhibitor and substrate for S-adenosylhomocysteine hydrolase inhibits bacterial lipopolysaccharide-induced transcription of tumor necrosis factor-alpha and interleukin-1beta in mouse macrophage RAW 264.7 cells.
1	Previously	previously	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	deazaadenosine	deazaadenosine	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	S-adenosylhomocysteine	S-adenosylhomocysteine	ADJ	JJ	Degree=Pos	_	_	_	_
19	hydrolase	hydrolase	NOUN	NN	Number=Sing	_	_	_	_
20	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
21	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
22	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
28	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
38	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
39	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
40	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7110
# text = In this study, we demonstrate the effects of DZA on nuclear factor-kappaB (NF-kappaB) regulation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	DZA	DZa	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-kappaB	-kappaB	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7111
# text = DZA inhibits the transcriptional activity of NF-kappaB through the hindrance of p65 (Rel-A) phosphorylation without reduction of its nuclear translocation and DNA binding activity.
1	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	hindrance	hindrance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p65	p65	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	without	without	ADP	IN	_	_	_	_	_
22	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7112
# text = The inhibitory effect of DZA on NF-kappaB transcriptional activity is potentiated by the addition of homocysteine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	homocysteine	homocysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7113
# text = Taken together, DZA promotes the proteolytic degradation of IkappaBalpha, but not IkappaBbeta, resulting in an increase of DNA binding activity of NF-kappaB in the nucleus in the absence of its transcriptional activity in RAW 264.7 cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
5	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
40	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7114
# text = The reduction of IkappaBalpha by DZA is neither involved in IkappaB kinase complex activation nor modulated by the addition of homocysteine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	neither	neither	ADV	RB	_	_	_	_	_
9	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	IkappaB	Ikappab	ADJ	JJ	Degree=Pos	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	nor	nor	CCONJ	CC	_	_	_	_	_
16	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	homocysteine	homocysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7115
# text = This study strongly suggests that DZA may be a potent drug for the treatment of diseases in which NF-kappaB plays a central pathogenic role, as well as a useful tool for studying the regulation and physiological functions of NF-kappaB.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	DZA	DZA	PROPN	NNP	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
11	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathogenic	pathogenic	NOUN	NN	Number=Sing	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	as	as	ADV	RB	_	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
33	tool	tool	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	SCONJ	IN	_	_	_	_	_
35	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
40	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7116
# text = Document 0030011002 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011002	0030011002	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7117
# text = Inducible binding to the c-fos serum response element during T cell activation is regulated by a phosphotyrosine-containing protein.
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
8	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	phosphotyrosine	phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7118
# text = The proto-oncogene c-fos is an immediate-early gene, and one of the first genes transcribed after stimulation of most cells with a variety of ligands.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
4	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7119
# text = Fos expression may be a pivotal event in converting ligand-receptor interactions at the membrane into functional modulation of cell phenotype.
1	Fos	Fos	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
7	event	event	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	converting	converte	VERB	VBG	VerbForm=Ger	_	_	_	_
10	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
19	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7120
# text = The serum response element (SRE) in the c-fos regulatory region participates in induction of transcription by various growth factors and by phorbol esters and subsequent squelching of transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
27	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
30	squelching	squelching	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7121
# text = We show that an inducible protein complex (Band A) binds to SRE DNA within 10 min after mitogenic stimulation of human PBL-T, and becomes nondetectable by 60 min.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	Band	Band	PROPN	NNP	Number=Sing	_	_	_	_
10	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	SRE	SRE	VERB	VB	VerbForm=Inf	_	_	_	_
15	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	10	10	NUM	CD	NumType=Card	_	_	_	_
18	min	min	NOUN	NNS	Number=Plur	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	nondetectable	nondetectable	ADJ	JJ	Degree=Pos	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	60	60	NUM	CD	NumType=Card	_	_	_	_
33	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7122
# text = Band
1	Band	band	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 7123
# text = A contains the serum response factor plus additional factor(s).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	plus	plus	CCONJ	CC	_	_	_	_	_
8	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	s	s	X	AFX	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7124
# text = A protein that is phosphorylated on a tyrosine residue in resting PBL-T suppresses binding of a component of Band A to the SRE motif.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
9	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	component	component	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Band	Band	PROPN	NNP	Number=Sing	_	_	_	_
22	A	a	PROPN	NNP	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7125
# text = Upon stimulation of the cells, this protein no longer prevents binding of DNA by Band A, and suppression of binding is restored within 30 min.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	no	no	ADV	RB	_	_	_	_	_
10	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
11	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	Band	Band	PROPN	NNP	Number=Sing	_	_	_	_
17	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	SCONJ	IN	_	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	restored	restore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	30	30	NUM	CD	NumType=Card	_	_	_	_
27	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7126
# text = The phosphorylated tyrosine residue itself is important for the protein-protein interaction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
5	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7127
# text = Document 0030011007 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011007	0030011007	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7128
# text = Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors.
1	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	NF-kappaB	NF-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Notch	notch	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	Notch	notch	PROPN	NNP	Number=Sing	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7129
# text = Jagged1 belongs to the DSL family of ligands for Notch receptors that control the proliferation and differentiation of various cell lineages.
1	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
2	belongs	belong	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	DSL	dsl	NOUN	NN	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	Notch	notch	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7130
# text = However, little is known about the transcription factors that regulate its expression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	about	about	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7131
# text = Here, we show that Jagged1 is a Rel/NF-kappaB-responsive gene.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Rel/	rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7132
# text = Both c-Rel and RelA induced jagged1 gene expression, whereas a mutant defective for transactivation did not.
1	Both	both	DET	DT	_	_	_	_	_
2	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	jagged	jag	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
16	defective	defective	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
19	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7133
# text = Importantly, jagged1 transcripts were also upregulated by endogenous NF-kappaB activation and this effect was inhibited by a dominant mutant of IkappaBalpha, a physiological inhibitor of NF-kappaB.
1	Importantly	importantly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	jagged	jag	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
29	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7134
# text = Cell surface expression of Jagged1 in c-Rel-expressing cell monolayers led to a functional interaction with lymphocytes expressing the Notch1/TAN-1 receptor.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-expressing	-expresse	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
13	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Notch1	notch1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	TAN	Tan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7135
# text = This correlated with the initiation of signaling downstream of Notch, as evidenced by increased levels of HES-1 transcripts in co-cultivated T cells and of CD23 transcripts in co-cultivated B cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
8	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Notch	notch	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HES	he	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	co-cultivated	co-cultivated	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
29	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	co-cultivated	co-cultivated	ADJ	JJ	Degree=Pos	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7136
# text = Consistent with its Rel/NF-kappaB-dependent induction, Jagged1 was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	Rel/NF	Rel/NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	highly	highly	ADV	RB	_	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	where	where	ADV	WRB	PronType=Rel	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	constitutively	constitutively	ADV	RB	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7137
# text = These results demonstrate that c-Rel can trigger the Notch signaling pathway in neighboring cells by inducing jagged1 gene expression, and suggest a role for Jagged1 in B-cell activation, differentiation or function.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Notch	notch	NOUN	NN	Number=Sing	_	_	_	_
11	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	neighboring	neighbore	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	jagged	jag	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	Jagged1	Jagged1	PROPN	NNP	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7138
# text = These findings also highlight the potential for an interplay between the Notch and NF-kappaB signaling pathways in the immune system.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	highlight	highlight	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Notch	notch	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7139
# text = Document 0030011012 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011012	0030011012	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7140
# text = Transcription factor AP-2 activates gene expression of HTLV-I.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
7	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7141
# text = The HTLV-I LTR contains three conserved regulatory elements known as 21 base pair repeats which are required for stimulation of gene expression by the transactivator protein tax.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	conserved	conserved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
11	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	21	21	NUM	CD	NumType=Card	_	_	_	_
14	base	base	NOUN	NN	Number=Sing	_	_	_	_
15	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
16	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7142
# text = Mutagenesis indicates that the 21 bp repeats can be subdivided into three motifs, A, B and C, each of which influences the level of tax activation.
1	Mutagenesis	Mutagenesis	PROPN	NNP	Number=Sing	_	_	_	_
2	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	21	21	NUM	CD	NumType=Card	_	_	_	_
6	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
7	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	subdivided	subdivide	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	three	three	NUM	CD	NumType=Card	_	_	_	_
13	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	each	each	DET	DT	_	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7143
# text = The A site in the 21 bp repeat has strong homology with previously described binding sites for the transcription factor AP-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	21	21	NUM	CD	NumType=Card	_	_	_	_
7	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
8	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
11	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7144
# text = We demonstrated that AP-2 mRNA was present in T-lymphocytes and that cellular factors from both non-transformed and transformed T-lymphocytes specifically bound to the consensus motif for AP-2 in each 21 bp.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	non-transformed	non-transformed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	specifically	specifically	ADV	RB	_	_	_	_	_
25	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
29	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	each	each	DET	DT	_	_	_	_	_
36	21	21	NUM	CD	NumType=Card	_	_	_	_
37	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7145
# text = To determine the role of AP-2 in the regulation of the HTLV-I LTR gene expression, we used an AP-2 cDNA in DNA binding and transient expression assays.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	LTR	Ltr	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
30	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7146
# text = Gel retardation and methylation interference studies revealed that bacterially produced AP-2 bound specifically and with high affinity to all three 21 bp repeats, and that it required the core sequence AGGC for specific binding.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	_
5	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	bacterially	bacterially	ADV	RB	_	_	_	_	_
10	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	bound	bound	NOUN	NN	Number=Sing	_	_	_	_
15	specifically	specifically	ADV	RB	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	all	all	DET	DT	_	_	_	_	_
22	three	three	NUM	CD	NumType=Card	_	_	_	_
23	21	21	NUM	CD	NumType=Card	_	_	_	_
24	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
25	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
30	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	core	core	NOUN	NN	Number=Sing	_	_	_	_
33	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
34	AGGC	Aggc	NOUN	NN	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7147
# text = Binding of AP-2 prevented the subsequent binding of members of the CREB/ATF family to an adjacent regulatory motif in the 21 bp repeat.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	members	member	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	21	21	NUM	CD	NumType=Card	_	_	_	_
26	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
27	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7148
# text = Transfection of an AP-2 expression construct into T-lymphocytes activated gene expression from the HTLV-I LTR.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	LTR	LTR	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7149
# text = At least two 21 bp repeats were required for high levels of AP-2 activation and mutagenesis of the AP-2 consensus binding sequences in the 21 bp repeats eliminate this activation.
1	At	at	ADV	RB	_	_	_	_	_
2	least	least	ADV	RBS	Degree=Sup	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	21	21	NUM	CD	NumType=Card	_	_	_	_
5	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
6	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	21	21	NUM	CD	NumType=Card	_	_	_	_
30	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
31	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
32	eliminate	eliminate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7150
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7151
# text = Document 0030011018 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011018	0030011018	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7152
# text = Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	microE5	microe5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	motif.	motif.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 7153
# text = Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
5	heavy	heavy	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	light	light	NOUN	NN	Number=Sing	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
12	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
16	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	developmentally	developmentally	ADV	RB	_	_	_	_	_
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7154
# text = Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNAs	Dna	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	denoted	denote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	ITF	ITF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	ITF	Itf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	types	type	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	microE5	microe5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
36	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	both	both	DET	DT	_	_	_	_	_
39	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	light	light	NOUN	NN	Number=Sing	_	_	_	_
43	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
44	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7155
# text = The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNAs	Dna	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	products	product	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	yet	yet	CCONJ	CC	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	ITF	Itf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	ITF	Itf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	structurally	structurally	ADV	RB	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	functionally	functionally	ADV	RB	_	_	_	_	_
24	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7156
# text = The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	another	another	DET	DT	_	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
11	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
15	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	each	each	DET	DT	_	_	_	_	_
18	possesses	possess	NOUN	NNS	Number=Plur	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	dictates	dictate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7157
# text = Document 0030011024 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011024	0030011024	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7158
# text = Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
4	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	conditioned	condition	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	medium	medium	ADJ	JJ	Degree=Pos	_	_	_	_
16	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
17	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
18	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
19	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	transendothelial	transendothelial	VERB	VB	VerbForm=Inf	_	_	_	_
22	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7159
# text = The abnormal adherence of sickle red blood cells (SS RBC) to endothelial cells has been thought to contribute to vascular occlusion, a major cause of morbidity in sickle cell disease (SCD).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
3	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
6	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
7	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	SS	SS	PROPN	NNP	Number=Sing	_	_	_	_
11	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
23	occlusion	occlusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
27	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	morbidity	morbidity	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	SCD	Scd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7160
# text = We determined whether the interaction of SS RBC with cultured endothelial cells induced cellular oxidant stress that would culminate in expression of cell adhesion molecules (CAMs) involved in the adhesion and diapedesis of monocytes and the adherence of SS reticulocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	SS	Ss	PROPN	NNP	Number=Sing	_	_	_	_
8	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
15	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
16	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
19	culminate	culminate	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
25	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	CAMs	CAM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	diapedesis	diapedesis	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	SS	ss	NOUN	NN	Number=Sing	_	_	_	_
42	reticulocytes	reticulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7161
# text = We showed that the interaction of SS RBC at 2% concentration in the presence of multimers of von Willebrand factor (vWf), derived from endothelial cell-derived conditioned medium (E-CM) with cultured human umbilical vein endothelial cells (HUVEC), resulted in a fivefold increased formation of thiobarbituric acid-reactive substances (TBARS) and activation of the transcription factor NF-kB, both indicators of cellular oxidant stress.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	SS	SS	PROPN	NNP	Number=Sing	_	_	_	_
8	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	multimers	multimer	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	von	von	PROPN	NNP	Number=Sing	_	_	_	_
20	Willebrand	Willebrand	PROPN	NNP	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	vWf	vWf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	conditioned	condition	ADJ	JJ	Degree=Pos	_	_	_	_
33	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	E	e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	CM	cm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
43	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
44	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	fivefold	fivefold	NOUN	NN	Number=Sing	_	_	_	_
54	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	thiobarbituric	thiobarbituric	ADJ	JJ	Degree=Pos	_	_	_	_
58	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
61	substances	substance	NOUN	NNS	Number=Plur	_	_	_	_
62	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
63	TBARS	Tbar	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
69	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
70	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
71	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
73	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
74	,	,	PUNCT	,	_	_	_	_	_
75	both	both	CCONJ	CC	_	_	_	_	_
76	indicators	indicator	NOUN	NNS	Number=Plur	_	_	_	_
77	of	of	ADP	IN	_	_	_	_	_
78	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
79	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
80	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7162
# text = Normal RBC show none of these phenomena.
1	Normal	normal	PROPN	NNP	Number=Sing	_	_	_	_
2	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	_
3	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	none	none	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	phenomena	phenomena	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7163
# text = The oxidant stress-induced signaling resulted in an increased surface expression of a subset of CAMs, ICAM-1, E-selectin, and VCAM-1 in HUVEC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
3	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CAMs	CAM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7164
# text = The addition of oxygen radical scavenger enzymes (catalase, superoxide dismutase) and antioxidant (probucol) inhibited these events.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
5	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
6	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
7	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	superoxide	superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
12	dismutase	dismutase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	probucol	probucol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7165
# text = Additionally, preincubation of HUVEC with a synthetic peptide Arg-Gly-Asp (RGD) that prevents vWf-mediated adhesion of SS RBC reduced the surface expression of VCAM-1 and NF-kB activation.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
9	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
10	Arg-	Arg-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	Gly	Gly	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Asp	Asp	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	RGD	RGD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	vWf	vWf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	SS	SS	PROPN	NNP	Number=Sing	_	_	_	_
25	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	_
26	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kB	kb	NOUN	NN	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7166
# text = Furthermore, SS RBC-induced oxidant stress resulted in a twofold increase in the transendothelial migration of both monocyte-like HL-60 cells and human peripheral blood monocytes, and approximately a sixfold increase in platelet-endothelial cell adhesion molecule-1 (PECAM-1) phosphorylation, each of which was blocked by protein kinase C inhibitor and antioxidants.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	SS	Ss	PROPN	NNP	Number=Sing	_	_	_	_
4	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
8	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
9	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	twofold	twofold	NOUN	NN	Number=Sing	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
23	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	60	60	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
31	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	approximately	approximately	ADV	RB	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	sixfold	sixfold	ADJ	JJ	Degree=Pos	_	_	_	_
37	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
44	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-1	-1	NUM	CD	NumType=Card	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	each	each	DET	DT	_	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	which	which	PRON	WDT	PronType=Rel	_	_	_	_
56	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
57	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
58	by	by	ADP	IN	_	_	_	_	_
59	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
60	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
61	C	c	NOUN	NN	Number=Sing	_	_	_	_
62	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7167
# text = These results suggest that the adherence/contact of SS RBC to endothelial cells in large vessel can generate enhanced oxidant stress leading to increased adhesion and diapedesis of monocytes, as well as heightened adherence of SS reticulocytes, indicating that injury/activation of endothelium can contribute to vaso-occlusion in SCD.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	SS	SS	PROPN	NNP	Number=Sing	_	_	_	_
11	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
17	vessel	vessel	NOUN	NN	Number=Sing	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
22	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
23	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	diapedesis	diapedesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	heightened	heighten	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	SS	ss	NOUN	NN	Number=Sing	_	_	_	_
39	reticulocytes	reticulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
42	that	that	SCONJ	IN	_	_	_	_	_
43	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	/activation	/activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
47	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
48	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
49	to	to	PART	TO	_	_	_	_	_
50	vaso	vaso	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
51	-occlusion	-occlusion	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	SCD	SCD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7168
# text = Document 0030011026 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011026	0030011026	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7169
# text = Two distinct signalling pathways are involved in the control of the biphasic junB transcription induced by interleukin-6 in the B cell hybridoma 7TD1.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
4	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
13	junB	junb	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
24	hybridoma	hybridoma	PROPN	NNP	Number=Sing	_	_	_	_
25	7TD1	7td1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7170
# text = We have measured the level of junB mRNA in the B hybridoma cell line 7TD1, under interleukin-6 (IL-6) stimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	level	level	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	hybridoma	hybridoma	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	7TD1	7td1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	under	under	ADP	IN	_	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7171
# text = IL-6 increases junB mRNA in a biphasic fashion.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
5	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
10	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7172
# text = The first early-induced peak was transient and likely corresponds to the well documented typical junB mRNA, stimulated in response to numerous growth factors, including IL-6.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	early	early	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
4	-induced	-induced	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
10	corresponds	corresponds	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
16	junB	junb	PROPN	NNP	Number=Sing	_	_	_	_
17	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
24	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7173
# text = At variance, the second peak which has never been reported previously, lasted several hours.
1	At	at	ADP	IN	_	_	_	_	_
2	variance	variance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	never	never	ADV	RB	_	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	lasted	last	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
16	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7174
# text = As a consequence of its effect on junB mRNA, IL-6 stimulated, in a biphasic fashion, the nuclear accumulation of the JunB protein.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
19	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7175
# text = In this study, we demonstrated that IL-6 regulation occurred exclusively at the transcriptional level and that the bimodal increase of junB mRNA and JunB protein can be accounted for by a biphasic stimulation of junB transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	exclusively	exclusively	ADV	RB	_	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	bimodal	bimodal	ADJ	JJ	Degree=Pos	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
25	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	accounted	account	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
36	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	junB	junb	NOUN	NN	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7176
# text = Furthermore, our data point to two major differences between the mechanism of control of the early and the late IL-6-induced junB transcription waves.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	point	point	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	control	control	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	junB	junb	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	waves	wafe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7177
# text = First, cycloheximide strongly potentiated the transcription of the second wave, whereas it failed to affect the early-induced burst.
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cycloheximide	cycloheximide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	wave	wave	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	early	early	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	burst	burst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7178
# text = Second, tyrphostin, a tyrosine kinase inhibitor, impaired the expression of the first but not the second junB mRNA peak.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tyrphostin	tyrphostin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	impaired	impaire	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
20	junB	junb	NOUN	NN	Number=Sing	_	_	_	_
21	mRNA	mRNa	ADP	IN	_	_	_	_	_
22	peak	peak	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7179
# text = Conversely, genistein, another tyrosine kinase inhibitor, totally abolished the expression of the second peak of junB mRNA whereas it did not affect the expression of the first peak.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	another	another	DET	DT	_	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	totally	totally	ADV	RB	_	_	_	_	_
11	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
17	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
31	peak	peak	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7180
# text = Altogether these data indicate that, in 7TD1 cells, IL-6 controls junB transcription in a biphasic fashion by means of two separate transduction pathways.
1	Altogether	altogether	ADV	RB	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	7TD1	7TD1	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	controls	control	NOUN	NN	Number=Sing	_	_	_	_
15	junB	junb	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
20	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	means	means	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
26	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
27	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7181
# text = Document 0030011027 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011027	0030011027	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7182
# text = IFN-gamma priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and MRNA stability.
1	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	priming	priming	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	MRNA	MRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7183
# text = The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	highly	highly	ADV	RB	_	_	_	_	_
20	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	host	host	NOUN	NN	Number=Sing	_	_	_	_
22	defence	defence	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7184
# text = The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	augmentation	augmentation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
5	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	referred	refer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	well	well	ADV	RB	Degree=Pos	_	_	_	_
22	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7185
# text = However, the mechanism(s) by which priming occurs is poorly defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	s	s	X	AFX	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	priming	priming	ADJ	JJ	Degree=Pos	_	_	_	_
11	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	poorly	poorly	ADV	RB	_	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7186
# text = Using tumour necrosis factor (TNF) induction as a model, experiments were designed to analyse in detail the priming effect on the LPS response in human monocytes.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	tumour	tumour	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	analyse	analyse	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	detail	detail	NOUN	NN	Number=Sing	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7187
# text = Priming by IFN-gamma was primarily manifested at the level of TNF mRNA accumulation.
1	Priming	Prime	VERB	VBG	VerbForm=Ger	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	primarily	primarily	ADV	RB	_	_	_	_	_
8	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
15	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7188
# text = IFN-gamma pre-treatment affected the magnitude rather than the sensitivity of the LPS response.
1	IFN-	IFN-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	pre-treatment	pre-treatment	NOUN	NN	Number=Sing	_	_	_	_
4	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
7	rather	rather	ADV	RB	_	_	_	_	_
8	than	than	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7189
# text = Priming occurred after several hours of treatment, and the primed state was induced by either IFN-gamma or GM-CSF, but not M-CSF.
1	Priming	Prime	PROPN	NNP	Number=Sing	_	_	_	_
2	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	after	after	ADP	IN	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
12	state	state	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7190
# text = Primed monocytes transcribed TNF mRNA at a higher rate than freshly isolated monocytes upon activation with LPS.
1	Primed	Prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
9	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
10	than	than	SCONJ	IN	_	_	_	_	_
11	freshly	freshly	ADV	RB	_	_	_	_	_
12	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	upon	upon	ADP	IN	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7191
# text = The increased transcriptional rate correlated with a marked increase in nuclear factor-kappa B activity in these cells as determined by electrophoretic mobility shift assay using a consensus NF-kappa B oligonucleotide.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	SCONJ	IN	_	_	_	_	_
21	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
24	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
27	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7192
# text = An additional significant finding was than TNF mRNA induced in primed cells was much more stable than in unprimed cells (T1/2 increased 6-8-fold).
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
4	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	than	than	ADP	IN	_	_	_	_	_
7	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	much	much	ADV	RB	_	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	T1	t1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7193
# text = Consistent with the increased mRNA stability, the duration of mRNA accumulation was longer following LPS stimulation in primed monocytes, in addition to being of greater magnitude.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	SCONJ	IN	_	_	_	_	_
25	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
28	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7194
# text = Finally, primed and unprimed cells possessed a differential sensitivity to the kinase inhibitor H-89.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	possessed	possess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	89	89	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7195
# text = H-89 substantially suppressed LPS-induced TNF mRNA accumulation in unprimed cells, but had no effect on primed monocytes following LPS stimulation.
1	H	h	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	89	89	NUM	CD	NumType=Card	_	_	_	_
4	substantially	substantially	ADV	RB	_	_	_	_	_
5	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
24	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7196
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7197
# text = Document 0030011029 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011029	0030011029	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7198
# text = Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PAF	PAF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	positively	positively	ADV	RB	_	_	_	_	_
9	auto	auto	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	PAF	PAF	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	through	through	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7199
# text = The human platelet-activating factor receptor (PAFR) gene is transcribed by two distinct promoters (promoter 1 and promoter 2) to generate two transcripts (designated as PAFR transcript 1 and PAFR transcript 2), though their open reading frames are identical.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PAFR	PAFR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	2	2	X	LS	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
27	two	two	NUM	CD	NumType=Card	_	_	_	_
28	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	PAFR	Pafr	PROPN	NNP	Number=Sing	_	_	_	_
33	transcript	transcript	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	PAFR	Pafr	NOUN	NN	Number=Sing	_	_	_	_
37	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	though	though	ADV	RB	_	_	_	_	_
42	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
43	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
44	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
45	frames	frame	NOUN	NNS	Number=Plur	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7200
# text = By primer extension analysis to discriminate two transcripts, we found that the levels of PAFR transcript 1 (leukocyte-type), but not PAFR transcript 2 (tissue-type), are upregulated by PAF as well as by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the human stomach cancer cell line (JR-St cells) which expresses both functional PAFR transcript 1 and PAFR transcript 2 endogenously.
1	By	by	ADP	IN	_	_	_	_	_
2	primer	primer	ADJ	JJ	Degree=Pos	_	_	_	_
3	extension	extension	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	discriminate	discriminate	VERB	VB	VerbForm=Inf	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	PAFR	PAFR	NOUN	NN	Number=Sing	_	_	_	_
17	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	PAFR	Pafr	ADV	RBR	Degree=Cmp	_	_	_	_
28	transcript	transcript	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
40	as	as	ADV	RB	_	_	_	_	_
41	well	well	ADV	RB	Degree=Pos	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	O	o	INTJ	UH	_	_	_	_	SpaceAfter=No
47	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
48	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-acetate	-acetate	ADJ	JJ	Degree=Pos	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	TPA	TPA	X	LS	_	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
56	stomach	stomach	NOUN	NN	Number=Sing	_	_	_	_
57	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
58	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
59	line	line	NOUN	NN	Number=Sing	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	JR	JR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	St	St	PROPN	NNP	Number=Sing	_	_	_	_
64	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	which	which	PRON	WDT	PronType=Rel	_	_	_	_
67	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
68	both	both	DET	DT	_	_	_	_	_
69	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
70	PAFR	Pafr	NOUN	NN	Number=Sing	_	_	_	_
71	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
72	1	1	NUM	CD	NumType=Card	_	_	_	_
73	and	and	CCONJ	CC	_	_	_	_	_
74	PAFR	Pafr	NOUN	NN	Number=Sing	_	_	_	_
75	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
76	2	2	NUM	CD	NumType=Card	_	_	_	_
77	endogenously	endogenously	ADV	RB	_	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7201
# text = Functional analysis of the promoter 1 with a transient expression assay using chloramphenicol acetyltransferase (CAT) gene as a reporter showed that both PAF and TPA activated the promoter 1 but not the deleted promoter lacking the three consensus binding sites for NF-kappa B located from -571 bp to -459 bp.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
12	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
13	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
14	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
22	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	both	both	CCONJ	CC	_	_	_	_	_
25	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
28	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	three	three	NUM	CD	NumType=Card	_	_	_	_
40	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
41	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
42	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
47	B	b	NOUN	NN	Number=Sing	_	_	_	_
48	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	from	from	ADP	IN	_	_	_	_	_
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	571	571	NUM	CD	NumType=Card	_	_	_	_
52	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
53	to	to	ADP	IN	_	_	_	_	_
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	459	459	NUM	CD	NumType=Card	_	_	_	_
56	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7202
# text = These findings suggest a molecular mechanism of positive regulation of PAFR gene expression by PAF through NF-kappa B, possibly by a phosphorylation reaction involving protein kinase C by PAF.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PAFR	Pafr	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	possibly	possibly	ADV	RB	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
27	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	C	C	PROPN	NNP	Number=Sing	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7203
# text = Document 0030011031 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011031	0030011031	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7204
# text = Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis [see comments]
1	Immunosuppression	Immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	B	PROPN	NNP	Number=Sing	_	_	_	_
18	synthesis	synthesis	PROPN	NNPS	Number=Plur	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
21	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7205
# text = Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	among	among	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	most	most	ADV	RBS	_	_	_	_	_
6	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
7	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7206
# text = They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	almost	almost	ADV	RB	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	known	known	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	immune	immune	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7207
# text = Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B (NF-kappa B) activation in mice and cultured cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7208
# text = This inhibition is mediated by induction of the I kappa B alpha inhibitory protein, which traps activated NF-kappa B in inactive cytoplasmic complexes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	I	I	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	traps	traps	NOUN	NNS	Number=Plur	_	_	_	_
18	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
26	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7209
# text = Because NF-kappa B activates many immunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	b	PROPN	NNP	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
8	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	pro-inflammatory	pro-inflammatory	VERB	VB	VerbForm=Inf	_	_	_	_
14	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
25	component	component	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7210
# text = Document 0030011033 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011033	0030011033	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7211
# text = Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.
1	Calcium	calcium	PROPN	NNP	Number=Sing	_	_	_	_
2	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7212
# text = The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
3	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
4	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
5	A	a	NOUN	NN	Number=Sing	_	_	_	_
6	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	normally	normally	ADV	RB	_	_	_	_	_
22	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7213
# text = When bound to cyclophilin, cyclosporin
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7214
# text = A binds and inactivates the key signalling intermediate calcineurin.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	inactivates	inactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	key	key	NOUN	NN	Number=Sing	_	_	_	_
7	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
8	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
9	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7215
# text = To identify potential cellular homologues of cyclosporin
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	homologues	homologue	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7216
# text = A that might regulate calcium signalling, we have cloned human genes encoding cyclophilin B-binding-proteins using the yeast two-hybrid system.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
4	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
5	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
6	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
14	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
15	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
25	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7217
# text = One gene product, when overexpressed in Jurkat T cells, specifically induced transcription from the interleukin-2 enhancer, by activating the T-cell-specific transcription factors NF-AT and NF-IL2A.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	IL2A	IL2A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7218
# text = This protein, termed calcium-signal modulating cyclophilin ligand (CAML), acts downstream of the TCR and upstream of calcineurin by causing an influx of calcium.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	calcium-	calcium-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	signal	signal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
7	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	influx	influx	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7219
# text = CAML appears to be a new participant in the calcium-signal transduction pathway, implicating cyclophilin B in calcium signalling, even in the absence of cyclosporin.
1	CAML	caml	NOUN	NN	Number=Sing	_	_	_	_
2	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
7	participant	participant	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	calcium-	calcium-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	even	even	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7220
# text = Document 0030011036 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011036	0030011036	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7221
# text = Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	defensin	defensin	ADJ	JJ	Degree=Pos	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	phoP	phoP	NOUN	NN	Number=Sing	_	_	_	_
12	virulence	virulence	NOUN	NN	Number=Sing	_	_	_	_
13	regulon	regulon	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Salmonella	Salmonella	PROPN	NNP	Number=Sing	_	_	_	_
16	typhimurium	typhimurium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7222
# text = The defensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using purified defensins NP-1 and NP-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	defensin	defensin	NOUN	NN	Number=Sing	_	_	_	_
3	sensitivities	sensitivity	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Salmonella	Salmonella	PROPN	NNP	Number=Sing	_	_	_	_
6	typhimurium	typhimurium	NOUN	NN	Number=Sing	_	_	_	_
7	strains	strain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phoP/	phop/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	component	component	ADJ	JJ	Degree=Pos	_	_	_	_
17	virulence	virulence	NOUN	NN	Number=Sing	_	_	_	_
18	regulon	regulon	NOUN	NN	Number=Sing	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	defensins	defensin	NOUN	NNS	Number=Plur	_	_	_	_
25	NP	NP	SYM	NFP	_	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	NP	Np	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7223
# text = Strains with mutations in either gene of the regulatory pair (phoP [transcriptional activator] or phoQ [membrane sensor kinase]) had increased sensitivities to defensin.
1	Strains	Strain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	either	either	DET	DT	_	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	phoP	phop	NOUN	NN	Number=Sing	_	_	_	_
13	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	]	]	PUNCT	-RRB-	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
21	sensor	sensor	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	sensitivities	sensitivity	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	defensin	defensin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7224
# text = The predicted periplasmic domain of the PhoQ protein contained a markedly anionic domain that could interact with cationic proteins and that could be responsible for resistance to defensin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	periplasmic	periplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PhoQ	Phoq	PROPN	NNP	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	markedly	markedly	ADV	RB	_	_	_	_	_
12	anionic	anionic	ADJ	JJ	Degree=Pos	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	cationic	cationic	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	defensin	defensin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7225
# text = Because insertion mutations in phoP are polar on phoQ, we constructed strains that expressed the PhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the phoQ gene product.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
3	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	phoP	phop	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	polar	polar	ADJ	JJ	Degree=Pos	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	strains	strain	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PhoQ	Phoq	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	PhoP	phop	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
26	whether	whether	SCONJ	IN	_	_	_	_	_
27	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	defensin	defensin	VERB	VB	VerbForm=Inf	_	_	_	_
30	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7226
# text = We found that resistance to defensin requires the function of both components of this regulatory system, because strains expressing PhoQ without PhoP were still markedly sensitive to defensins.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	defensin	defensin	VERB	VB	VerbForm=Inf	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	components	component	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	because	because	SCONJ	IN	_	_	_	_	_
19	strains	strain	NOUN	NNS	Number=Plur	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	PhoQ	Phoq	PROPN	NNP	Number=Sing	_	_	_	_
22	without	without	ADP	IN	_	_	_	_	_
23	PhoP	phop	PROPN	NNP	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	still	still	ADV	RB	_	_	_	_	_
26	markedly	markedly	ADV	RB	_	_	_	_	_
27	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	defensins	defensin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7227
# text = This implied that a pag (phoP-activated gene) product is responsible for defensin resistance.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	implied	imply	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	pag	pag	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	phoP-	phoP-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	product	product	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	defensin	defensin	ADJ	JJ	Degree=Pos	_	_	_	_
16	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7228
# text = We also tested for the ability of defensins NP-1, NP-5, and HNP-1 to activate pag expression and found that these peptides have no effect.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	defensins	defensin	NOUN	NNS	Number=Plur	_	_	_	_
9	NP	NP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	NP	NP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	HNP	HNP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
23	pag	pag	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
30	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	no	no	DET	DT	_	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7229
# text = Defensin resistance is not the only virulence characteristic controlled by the PhoP-PhoQ regulon because mutations in pagC, as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc), had no effect on defensin resistance, even though they rendered the organism avirulent and deficient in survival within macrophages.
1	Defensin	Defensin	PROPN	NNP	Number=Sing	_	_	_	_
2	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
7	virulence	virulence	NOUN	NN	Number=Sing	_	_	_	_
8	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	PhoP	phop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	PhoQ	Phoq	NOUN	NN	Number=Sing	_	_	_	_
15	regulon	regulon	NOUN	NN	Number=Sing	_	_	_	_
16	because	because	SCONJ	IN	_	_	_	_	_
17	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	pagC	pagC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	ones	one	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	phoP	phop	NOUN	NN	Number=Sing	_	_	_	_
28	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
33	pag	pag	NOUN	NN	Number=Sing	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
37	PhoPc	PhoPc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	no	no	DET	DT	_	_	_	_	_
42	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
43	on	on	ADP	IN	_	_	_	_	_
44	defensin	defensin	NOUN	NN	Number=Sing	_	_	_	_
45	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	even	even	ADV	RB	_	_	_	_	_
48	though	though	SCONJ	IN	_	_	_	_	_
49	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
50	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	organism	organism	NOUN	NN	Number=Sing	_	_	_	_
53	avirulent	avirulent	ADJ	JJ	Degree=Pos	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
58	within	within	ADP	IN	_	_	_	_	_
59	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7230
# text = The virulence defect conferred by mutations in the phoP-phoQ two-component regulatory system is not completely explained by alterations in resistance to cationic proteins and involves the control of other proteins necessary for S. typhimurium survival within macrophages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	virulence	virulence	NOUN	NN	Number=Sing	_	_	_	_
3	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
4	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	phoP-	phop-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	phoQ	phoq	NOUN	NN	Number=Sing	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	component	component	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	system	system	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	completely	completely	ADV	RB	_	_	_	_	_
19	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	cationic	cationic	ADJ	JJ	Degree=Pos	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
34	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
37	typhimurium	typhimurium	NOUN	NN	Number=Sing	_	_	_	_
38	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
39	within	within	ADP	IN	_	_	_	_	_
40	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7231
# text = Document 0030011040 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011040	0030011040	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7232
# text = AP-1 derived from mature monocytes and astrocytes preferentially interacts with the HTLV-I promoter central 21 bp repeat.
1	AP	ap	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	preferentially	preferentially	ADV	RB	_	_	_	_	_
11	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
18	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
19	21	21	NUM	CD	NumType=Card	_	_	_	_
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7233
# text = Characterization of the cellular transcription factors interacting with the human T cell lymphotropic virus type I (HTLV-I) long terminal repeat (LTR) is essential to dissecting the mechanisms involved in viral transcription that may be pertinent to the oncogenic and neuropathogenic processes associated with HTLV-I infection in both the immune and nervous systems.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphotropic	lymphotropic	ADJ	JJ	Degree=Pos	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	SCONJ	IN	_	_	_	_	_
31	dissecting	dissect	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
34	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	pertinent	pertinent	ADJ	JJ	Degree=Pos	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	neuropathogenic	neuropathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
47	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
48	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
52	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
53	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	both	both	CCONJ	CC	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
60	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7234
# text = Electrophoretic mobility shift (EMS) analyses utilizing oligonucleotides homologous to each of the 21 bp repeat elements reacted with nuclear extracts derived from cell lines of lymphocytic, monocytic, neuronal, and glial cell origin have demonstrated differential binding of cellular factors to the three 21 bp repeats (1-4).
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	EMS	EMS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	analyses	analyse	NOUN	NNS	Number=Plur	_	_	_	_
8	utilizing	utilizing	VERB	VBG	VerbForm=Ger	_	_	_	_
9	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	each	each	DET	DT	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	21	21	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	repeat	repeat	ADJ	JJ	Degree=Pos	_	_	_	_
18	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
19	reacted	react	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	neuronal	neuronal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
38	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
41	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
44	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	three	three	NUM	CD	NumType=Card	_	_	_	_
48	21	21	NUM	CD	NumType=Card	_	_	_	_
49	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
50	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
54	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7235
# text = ATF/CREB and Sp family members interacted with the 21 bp repeats to form DNA-protein complexes common to all cell types examined.
1	ATF/CREB	Atf/creb	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	Sp	sp	ADJ	JJ	Degree=Pos	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	members	member	NOUN	NNS	Number=Plur	_	_	_	_
6	interacted	interact	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	21	21	NUM	CD	NumType=Card	_	_	_	_
10	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
11	repeats	repeat	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
18	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	all	all	DET	DT	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	_
23	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7236
# text = However, a unique DNA-protein complex was detected when the promoter central 21 bp repeat was reacted with nuclear extracts derived from either the U-373 MG glioblastoma cell line or the THP-1 mature monocytic cell line.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	when	when	ADV	WRB	PronType=Int	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
15	21	21	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	reacted	react	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	either	either	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	U-	u-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	373	373	NUM	CD	NumType=Card	_	_	_	_
29	MG	MG	PROPN	NNP	Number=Sing	_	_	_	_
30	glioblastoma	glioblastoma	NOUN	NN	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	line	line	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	mature	mature	NOUN	NN	Number=Sing	_	_	_	_
39	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7237
# text = Based on nucleotide sequence requirements and immunoreactivity, we demonstrate that this DNA-protein complex is comprised of the AP-1 components, Fos and Jun.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	comprised	comprise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7238
# text = Document 0030011041 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011041	0030011041	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7239
# text = Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.
1	Histamine	Histamine	PRON	PRP	_	_	_	_	_
2	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
11	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	H2	h2	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	_
23	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7240
# text = We examined the effects of histamine and its agonists on the expression of the c-fos and c-myc proto-oncogenes at the transcriptional and translational levels in the human promonocytic U937 cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	histamine	histamine	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
20	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7241
# text = Histamine transiently increased cAMP and c-fos expression through H2 receptors.
1	Histamine	Histamine	ADV	RB	_	_	_	_	_
2	transiently	transiently	ADV	RB	_	_	_	_	_
3	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	H2	H2	NUM	CD	NumType=Card	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7242
# text = Dibutyryl cAMP also increased c-fos mRNA and protein, and levels remained elevated even after 12 hr of treatment.
1	Dibutyryl	Dibutyryl	PROPN	NNP	Number=Sing	_	_	_	_
2	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	even	even	ADV	RB	_	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	12	12	NUM	CD	NumType=Card	_	_	_	_
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7243
# text = Dose-dependence studies using histamine and dimaprit showed that the EC50 values for cAMP production and c-fos increase were similar, suggesting that cAMP might be involved in c-fos induction via H2 receptors.
1	Dose	Dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	histamine	histamine	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	dimaprit	dimaprit	NOUN	NN	Number=Sing	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EC50	EC50	NOUN	NN	Number=Sing	_	_	_	_
13	values	value	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
21	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
28	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
35	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
36	via	via	ADP	IN	_	_	_	_	_
37	H2	H2	NUM	CD	NumType=Card	_	_	_	_
38	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7244
# text = Furthermore, studies carried out using H7, a protein kinase A/protein kinase C inhibitor, blocked c-fos induction, whereas no effect was observed with bisindolylmaleimide, a specific protein kinase C inhibitor.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	out	out	ADP	RP	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	H7	H7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	no	no	DET	DT	_	_	_	_	_
27	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	bisindolylmaleimide	bisindolylmaleimide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
37	C	c	NOUN	NN	Number=Sing	_	_	_	_
38	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7245
# text = No modification of c-myc expression could be detected on treatment with histamine or its analogues.
1	No	no	DET	DT	_	_	_	_	_
2	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	histamine	histamine	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7246
# text = Nevertheless, dibutyryl cAMP induced a down-regulation of the levels of this proto-oncogene.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	dibutyryl	dibutyryl	ADJ	JJ	Degree=Pos	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	down	down	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-regulation	-regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7247
# text = In addition, dibutyryl cAMP inhibited cell growth in a dose-dependent manner, whereas histamine failed to affect proliferation and differentiation of U937 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	dibutyryl	dibutyryl	ADJ	JJ	Degree=Pos	_	_	_	_
5	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	histamine	histamine	PRON	PRP	_	_	_	_	_
18	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
21	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	U937	U937	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7248
# text = Cells pretreated with dimaprit showed a decrease in the cAMP response to subsequent addition of H2 agonists, whereas the cAMP response to prostaglandin E2 remained unaltered.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	dimaprit	dimaprit	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
14	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	H2	H2	NUM	CD	NumType=Card	_	_	_	_
17	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	prostaglandin	prostaglandin	VERB	VB	VerbForm=Inf	_	_	_	_
25	E2	E2	NUM	CD	NumType=Card	_	_	_	_
26	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	unaltered	unaltered	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7249
# text = This homologous mechanism of H2 receptor desensitization was time dependent.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	H2	H2	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	desensitization	desensitization	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7250
# text = These results indicate that histamine activates several mechanisms involved in the induction of differentiation, such as cAMP and c-fos production, but fails to promote differentiation of U937 cells, apparently due to the rapid desensitization of H2 receptors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	histamine	histamine	PRON	PRP	_	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
8	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
9	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	U937	U937	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	apparently	apparently	ADV	RB	_	_	_	_	_
35	due	due	ADP	IN	_	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
39	desensitization	desensitization	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	H2	H2	NUM	CD	NumType=Card	_	_	_	_
42	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7251
# text = Document 0030011047 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011047	0030011047	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7252
# text = Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	effector	effector	ADJ	JJ	Degree=Pos	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	+	+	SYM	SYM	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Th2	th2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7253
# text = Transcriptional factors of the NFAT family play an important role in regulating the expression of several cytokine genes during the immune response, such as the genes for interleukin 2 (IL-2) and IL-4, among others.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	X	LS	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	among	among	ADP	IN	_	_	_	_	_
42	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7254
# text = Upon antigen stimulation, precursor CD4+ T helper (pTh) cells proliferate and differentiate into two populations of effector cells (eTh1 and eTh2), each one expressing a specific pattern of cytokines that distinguishes them from their precursors.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
6	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	+	+	SYM	SYM	_	_	_	_	_
8	T	t	NUM	CD	NumType=Card	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	pTh	pTh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	proliferate	proliferate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	differentiate	differentiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	each	each	DET	DT	_	_	_	_	_
30	one	one	NOUN	NN	Number=Sing	_	_	_	_
31	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
37	that	that	PRON	WDT	PronType=Rel	_	_	_	_
38	distinguishes	distinguish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7255
# text = eTh2 cells are the major source of IL-4, while gamma interferon is produced by eTh1 cells.
1	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	source	source	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	while	while	SCONJ	IN	_	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7256
# text = Here we have used reporter transgenic mice to show that DNA binding and transcriptional activities of NFAT are transiently induced during the differentiation of pTh cells into either eTh1 or eTh2 cells to mediate the expression of IL-2 as a common growth factor in both pathways.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	transgenic	transgenic	NOUN	NN	Number=Sing	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NFAT	NFAT	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	transiently	transiently	ADV	RB	_	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	pTh	pTh	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	into	into	ADP	IN	_	_	_	_	_
28	either	either	CCONJ	CC	_	_	_	_	_
29	eTh1	eTh1	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
44	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	both	both	DET	DT	_	_	_	_	_
48	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7257
# text = However, although NFAT DNA binding is similarly induced in both eTh1 and eTh2 cells upon antigen stimulation, only the NFAT complexes present in eTh2 cells are able to mediate high-level transcription, and relatively little NFAT transcriptional activity was induced in eTh1 cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	NFAT	NFAT	SCONJ	IN	_	_	_	_	_
5	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	similarly	similarly	ADV	RB	_	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	upon	upon	ADP	IN	_	_	_	_	_
17	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
23	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
24	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	level	level	NOUN	NN	Number=Sing	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	relatively	relatively	ADV	RB	_	_	_	_	_
39	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
40	NFAT	Nfat	SCONJ	IN	_	_	_	_	_
41	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7258
# text = In contrast to activated pTh cells, neither eTh1 nor eTh2 cells produced significant IL-2 upon stimulation, but the high levels of NFAT transcriptional activities directly correlate with the IL-4 production induced in response to antigen stimulation in eTh2 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	pTh	pTh	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	neither	neither	CCONJ	CC	_	_	_	_	_
9	eTh1	eTh1	PROPN	NNP	Number=Sing	_	_	_	_
10	nor	nor	CCONJ	CC	_	_	_	_	_
11	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	upon	upon	ADP	IN	_	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
29	directly	directly	ADV	RB	_	_	_	_	_
30	correlate	correlate	ADV	RB	Degree=Pos	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	4	4	NUM	CD	NumType=Card	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	antigen	antigen	VERB	VB	VerbForm=Inf	_	_	_	_
42	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7259
# text = These data suggest that activated NFAT is involved in the effector function of eTh2 cells and that the failure of eTh1 cells to produce IL-4 in response to an antigen is due, at least partially, to a failure to induce high-level transcription of the IL-4 gene by NFAT.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	due	due	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	at	at	ADV	RB	_	_	_	_	_
37	least	least	ADV	RBS	Degree=Sup	_	_	_	_
38	partially	partially	ADV	RB	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
45	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	level	level	NOUN	NN	Number=Sing	_	_	_	_
48	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
53	4	4	NUM	CD	NumType=Card	_	_	_	_
54	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7260
# text = Regulation of NFAT could be therefore a critical element in the polarization to eTh1 or eTh2.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFAT	NFAT	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	therefore	therefore	ADV	RB	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	polarization	polarization	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	eTh1	eTh1	NUM	CD	NumType=Card	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	eTh2	eTh2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7261
# text = Document 0030011049 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011049	0030011049	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7262
# text = Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
6	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7263
# text = The nuclear factor of kappaB (NF-kappaB) is a ubiquitous transcription factor that is key in the regulation of the immune response and inflammation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7264
# text = T cell receptor (TCR) cross-linking is in part required for activation of NF-kappaB, which is dependent on the phosphorylation and degradation of IkappaBalpha.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	part	part	NOUN	NN	Number=Sing	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7265
# text = By using Jurkat and primary human T lymphocytes, we demonstrate that the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of the IkappaBalpha kinase (IKK) complex but not of another putative IkappaBalpha kinase, p90(rsk).
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	NOUN	NN	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
19	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	C	C	PROPN	NNP	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	results	result	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
45	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
50	but	but	CCONJ	CC	_	_	_	_	_
51	not	not	ADV	RB	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	another	another	DET	DT	_	_	_	_	_
54	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
55	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	p90	p90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	rsk	rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7266
# text = We also demonstrate that the IKK complex, but not p90(rsk), is responsible for the in vivo phosphorylation of IkappaBalpha mediated by the co-activation of PKC and calcineurin.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	p90	p90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	rsk	rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	co-activation	co-activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7267
# text = Each second messenger is necessary, as inhibition of either one reverses the activation of the IKK complex and IkappaBalpha phosphorylation in vivo.
1	Each	each	DET	DT	_	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	reverses	reverse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7268
# text = Overexpression of dominant negative forms of IKKalpha and -beta demonstrates that only IKKbeta is the target for PKC and calcineurin.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IKKalpha	IKKalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	IKKbeta	IKKbeta	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	target	target	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7269
# text = These results indicate that within the TCR/CD3 signal transduction pathway both PKC and calcineurin are required for the effective activation of the IKK complex and NF-kappaB in T lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TCR/	Tcr/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
25	complex	complex	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7270
# text = Document 0030011050 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011050	0030011050	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7271
# text = Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism.
1	Attenuated	Attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	variant	variant	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
22	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7272
# text = The Id family of helix-loop-helix proteins function as negative regulators of DNA binding, basic helix-loop-helix proteins in the regulation of cell growth and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Id	id	ADJ	JJ	Degree=Pos	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
19	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-loop	-loop	ADP	IN	_	_	_	_	SpaceAfter=No
21	-helix	-helix	ADJ	JJ	Degree=Pos	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7273
# text = We report here on the identification of a 17 kDa variant of the 14 kDa Id-3 protein termed Id-3L (long version) which possesses a unique 60 amino acid carboxy-terminus generated by read through of a 'coding intron' and alternative splicing.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	17	17	NUM	CD	NumType=Card	_	_	_	_
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	14	14	NUM	CD	NumType=Card	_	_	_	_
15	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
16	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	3L	3L	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
26	version	version	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	possesses	possess	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
32	60	60	NUM	CD	NumType=Card	_	_	_	_
33	amino	amino	DET	DT	_	_	_	_	_
34	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
35	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
38	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	read	read	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
45	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
46	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	'	'	PUNCT	''	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
50	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7274
# text = Northern analysis revealed expression of a minor 1.1 kb
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
8	1.1	1.1	NUM	CD	NumType=Card	_	_	_	_
9	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7275
# text = Id-3L transcript together with the predominant 0.95 kb
1	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3L	3L	AUX	MD	VerbForm=Fin	_	_	_	_
4	transcript	transcriep	VERB	VB	VerbForm=Inf	_	_	_	_
5	together	together	ADV	RB	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	0.95	0.95	NUM	CD	NumType=Card	_	_	_	_
10	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7276
# text = Id-3 transcript in the majority of adult human tissues analysed.
1	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
12	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7277
# text = The variant Id-3L protein is functionally distinguishable from conventional Id-3 since in in vitro DNA mobility shift assays, it was greatly impaired in its ability to abrogate binding of the basic helix-loop-helix protein, E47, to an E box recognition sequence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	variant	variant	ADJ	JJ	Degree=Pos	_	_	_	_
3	Id	id	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	3L	3L	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	functionally	functionally	ADV	RB	_	_	_	_	_
9	distinguishable	distinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	conventional	conventional	ADJ	JJ	Degree=Pos	_	_	_	_
12	Id	id	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	since	since	ADP	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	greatly	greatly	ADV	RB	_	_	_	_	_
27	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	abrogate	abrogate	VERB	VB	VerbForm=Inf	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
37	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-helix	-helix	NOUN	NN	Number=Sing	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	E47	E47	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	E	e	NOUN	NN	Number=Sing	_	_	_	_
46	box	box	NOUN	NN	Number=Sing	_	_	_	_
47	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
48	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7278
# text = Document 0030011051 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011051	0030011051	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7279
# text = Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression.
1	Lipopolysaccharide	Lipopolysaccharide	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
5	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	macrophage-specific	macrophage-specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	stimulator	stimulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7280
# text = Lipopolysaccharide (LPS) potently stimulates human immunodeficiency virus type 1-long terminal repeat (HIV-1-LTR) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line.
1	Lipopolysaccharide	Lipopolysaccharide	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	potently	potently	ADV	RB	_	_	_	_	_
6	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
14	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
15	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
24	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
25	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	into	into	ADP	IN	_	_	_	_	_
27	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	macrophage-like	macrophage-like	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	not	not	ADV	RB	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7281
# text = This effect appears to be mediated through the induction of nuclear factor kappa B (NF-kappa B).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7282
# text = Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and THP-1 cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
8	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	U937	U937	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7283
# text = LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line, U1, which produces very low levels of HIV-1 at baseline.
1	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	dramatically	dramatically	ADV	RB	_	_	_	_	_
7	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	chronically	chronically	ADV	RB	_	_	_	_	_
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	like	like	ADP	IN	_	_	_	_	_
21	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	U1	U1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	produces	produce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	very	very	ADV	RB	_	_	_	_	_
30	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
31	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7284
# text = The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor (GM-CSF) before treatment with LPS.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	if	if	SCONJ	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	before	before	ADP	IN	_	_	_	_	_
31	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7285
# text = This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of NF-kappa B. LPS is not able to induce HIV-1 production in a cloned T cell line.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_
30	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
36	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	production	production	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
45	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7286
# text = The effect of LPS on HIV-1 replication occurs at picogram per milliliter concentrations and may be clinically significant in understanding the variability of the natural history of HIV-1 infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	picogram	picogram	NOUN	NN	Number=Sing	_	_	_	_
13	per	per	ADP	IN	_	_	_	_	_
14	milliliter	milliliter	NOUN	NN	Number=Sing	_	_	_	_
15	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	clinically	clinically	ADV	RB	_	_	_	_	_
20	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	variability	variability	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
28	history	history	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7287
# text = Document 0030011054 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011054	0030011054	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7288
# text = Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7289
# text = MyD88, originally isolated as a myeloid differentiation primary response gene, is shown to act as an adaptor in interleukin-1 (IL-1) signaling by interacting with both the IL-1 receptor complex and IL-1 receptor-associated kinase (IRAK).
1	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	originally	originally	ADV	RB	_	_	_	_	_
4	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
30	by	by	SCONJ	IN	_	_	_	_	_
31	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	both	both	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7290
# text = Mice generated by gene targeting to lack MyD88 have defects in T cell proliferation as well as induction of acute phase proteins and cytokines in response to IL-1.
1	Mice	mouse	NOUN	NN	Number=Sing	_	_	_	_
2	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	lack	lack	VERB	VB	VerbForm=Inf	_	_	_	_
8	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	_
9	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
10	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
21	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7291
# text = Increases in interferon-gamma production and natural killer cell activity in response to IL-18 are abrogated.
1	Increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
9	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	18	18	NUM	CD	NumType=Card	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7292
# text = In vivo Th1 response is also impaired.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADV	RB	_	_	_	_	_
3	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7293
# text = Furthermore, IL-18-induced activation of NF-kappaB and c-Jun N-terminal kinase (JNK) is blocked in MyD88-/- Th1-developing cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
17	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	MyD88	MyD88	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-/-	-/-	PUNCT	.	_	_	_	_	_
28	Th1	Th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-developing	-develop	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7294
# text = Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
12	component	component	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADV	RB	_	_	_	_	_
26	well	well	ADV	RB	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	18	18	NUM	CD	NumType=Card	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7295
# text = Document 0030011061 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011061	0030011061	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7296
# text = Glucocorticoid-induced apoptosis and regulation of NF-kappaB activity in human leukemic T cells.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
3	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7297
# text = Glucocorticoid-induced apoptosis was investigated in glucocorticoid-sensitive 6TG1.1 and resistant ICR27TK.3 human leukemic T cells.
1	Glucocorticoid	Glucocorticoid	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
11	6TG1.1	6tg1.1	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
14	ICR27TK.3	ICR27TK.3	NUM	CD	NumType=Card	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7298
# text = Following glucocorticoid treatment of 6TG1.1 cells, chromatin fragmentation was observed after a delay of 24 h.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
9	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	delay	delay	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	24	24	NUM	CD	NumType=Card	_	_	_	_
17	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7299
# text = Fragmentation was not observed in ICR27TK.3 cells containing mutant glucocorticoid receptors (L753F) that are activation-deficient but retain the ability to repress AP-1 activity.
1	Fragmentation	Fragmentation	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	ICR27TK.3	ICR27TK.3	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
10	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	L753	L753	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	F	F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	retain	retain	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7300
# text = Nor was fragmentation observed after treatment with RU38486, indicating that repression of AP-1 activity is not involved.
1	Nor	nor	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	RU38486	RU38486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7301
# text = As described in other systems, fragmentation required ongoing protein synthesis.
1	As	as	SCONJ	IN	_	_	_	_	_
2	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7302
# text = However, inhibition of protein synthesis with cycloheximide anytime during the first 18 h of steroid treatment was as effective in blocking chromatin fragmentation as inhibition for the entire period, suggesting that synthesis of a component with a rapid turnover rate is required.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
9	anytime	anytime	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	18	18	NUM	CD	NumType=Card	_	_	_	_
14	h	h	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	as	as	ADV	RB	_	_	_	_	_
20	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	blocking	block	ADJ	JJ	Degree=Pos	_	_	_	_
23	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
24	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
30	period	period	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	component	component	NOUN	NN	Number=Sing	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
41	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
42	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
43	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7303
# text = Dexamethasone treatment completely blocked 12-O-tetradecanoylphorbol 13-acetate induction of nuclear factor-kappaB (NF-kappaB) activity and elicited an increase in the amount of immunoreactive IkappaB alpha in sensitive 6TG1.1 cells but not in resistant ICR27TK.3 cells.
1	Dexamethasone	Dexamethasone	ADJ	JJ	Degree=Pos	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	completely	completely	ADV	RB	_	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
10	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	elicited	elicit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
33	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
37	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	PART	RB	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
43	ICR27TK.3	ICR27TK.3	NUM	CD	NumType=Card	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7304
# text = In addition, mild detergent treatment of cell extracts indicated that a substantial amount of cytoplasmic NF-kappaB is complexed with IkappaB alpha or some other inhibitory factor.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mild	mild	ADJ	JJ	Degree=Pos	_	_	_	_
5	detergent	detergent	ADJ	JJ	Degree=Pos	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
10	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
14	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	complexed	complex	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	some	some	DET	DT	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7305
# text = These results suggest that induction of a labile inhibitory factor such as IkappaB alpha may contribute to glucocorticoid-induced apoptosis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	_
14	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7306
# text = Document 0030011065 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011065	0030011065	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7307
# text = Transcriptional regulation of the beta-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-talk	-talk	NOUN	NN	Number=Sing	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7308
# text = The beta-casein promoter has been widely used to monitor the activation of STAT (signal transducer and activator of transcription)5 since STAT5 was originally found as a mediator of PRL-inducible beta-casein expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	widely	widely	ADV	RB	_	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	since	since	ADP	IN	_	_	_	_	_
26	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	originally	originally	ADV	RB	_	_	_	_	_
29	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	PRL	PRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
37	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7309
# text = However, not only is expression of the beta-casein gene regulated by STAT5 but it is also affected by other molecules such as glucocorticoid and Ras.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	not	not	ADV	RB	_	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Ras	Ras	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7310
# text = In this report, we describe the transcriptional regulation of the beta-casein gene by cytokines in T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7311
# text = We have found that the beta-casein gene is expressed in a cytotoxic T cell line, CTLL-2, in response to interleukin-2 (IL-2), which activates STAT5.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	CTLL	CTLL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7312
# text = While IL-4 does not activate STAT5, it induces expression of STAT5-regulated genes in CTLL-2, i.e. beta-casein, a cytokine-inducible SH2-containing protein (CIS), and oncostatin M (OSM), suggesting that STAT6 activated by IL-4 substitutes for the function of STAT5 in T cells.
1	While	while	SCONJ	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
11	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	i.e.	i.e.	X	FW	_	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	casein	casein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	CIS	CIS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	oncostatin	oncostatin	ADJ	JJ	Degree=Pos	_	_	_	_
42	M	m	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	OSM	OSM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
48	that	that	SCONJ	IN	_	_	_	_	_
49	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
50	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	4	4	NUM	CD	NumType=Card	_	_	_	_
55	substitutes	substitute	NOUN	NNS	Number=Plur	_	_	_	_
56	for	for	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	function	function	NOUN	NN	Number=Sing	_	_	_	_
59	of	of	ADP	IN	_	_	_	_	_
60	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
61	in	in	ADP	IN	_	_	_	_	_
62	T	T	PROPN	NNP	Number=Sing	_	_	_	_
63	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7313
# text = IL-2-induced beta-casein expression was enhanced by dexamethasone, and this synergistic effect of Dexamethasone requires the sequence between -155 and -193 in the beta-casein promoter.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
21	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	155	155	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	193	193	NUM	CD	NumType=Card	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7314
# text = Coincidentally, a deletion of this region enhanced the IL-2-induced expression of beta-casein.
1	Coincidentally	Coincidentally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	casein	casein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7315
# text = Expression of an active form of Ras, Ras(G12V), suppressed the IL-2-induced beta-casein and OSM gene expression, and the negative effect of Ras is mediated by the region between -105 and -193 in the beta-casein promoter.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	form	form	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	G12	G12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	V	V	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	OSM	OSm	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
33	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	region	region	NOUN	NN	Number=Sing	_	_	_	_
41	between	between	ADP	IN	_	_	_	_	_
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	105	105	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
46	193	193	NUM	CD	NumType=Card	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7316
# text = In apparent contradiction, expression of a dominant negative form of Ras, RasN17, also inhibited IL-2-induced activation of the promoter containing the minimal beta-casein STAT5 element as well as the promoters of CIS and OSM.
1	In	in	ADP	IN	_	_	_	_	_
2	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
3	contradiction	contradiction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	form	form	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	RasN	RasN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
34	STAT5	stat5	NOUN	NN	Number=Sing	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	_
36	as	as	ADV	RB	_	_	_	_	_
37	well	well	ADV	RB	Degree=Pos	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	CIS	CIS	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	OSM	OSM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7317
# text = In addition, Ras(G12V) complemented signaling by an erythropoietin receptor mutant defective in Ras activation and augmented the activation of the beta-casein promoter by the mutant erythropoietin receptor signaling, suggesting a possible role of Ras in Stat5-mediated gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	G12	G12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	V	V	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	complemented	complement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
16	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
33	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
40	role	role	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7318
# text = These results collectively reveal a complex interaction of STAT5 with other signaling pathways and illustrate that regulation of gene expression requires integration of opposing signals.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	collectively	collectively	ADV	RB	_	_	_	_	_
4	reveal	reveal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	illustrate	illustrate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	opposing	oppos	ADJ	JJ	Degree=Pos	_	_	_	_
25	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7319
# text = Document 0030011067 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011067	0030011067	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7320
# text = Induction of transcription factors in human T lymphocytes by aspirin-like drugs.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	aspirin	aspirin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7321
# text = Aspirin-like drugs (ALD) induce calcium mobilization, an essential component of T cell activation, but do not induce the biosynthesis of IL-2.
1	Aspirin	aspirin	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	like	like	ADP	IN	_	_	_	_	_
4	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	ALD	ALD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
9	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
10	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
14	component	component	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	biosynthesis	biosynthesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7322
# text = To understand the extent to which ALD may mimic mitogenic stimulation, we studied cytoplasmic and nuclear signaling steps in ALD-treated T cells.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
10	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
19	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7323
# text = We found that ALD induce a transient activation of protein kinase (PKC) but have no effect (in comparison to anti-CD3 antibodies) on protein tyrosine phosphorylation nor on PCL gamma 1 tyrosine phosphorylation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	no	no	DET	DT	_	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	in	in	ADP	IN	_	_	_	_	_
21	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
24	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
29	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
30	nor	nor	CCONJ	CC	_	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	PCL	pCl	NOUN	NN	Number=Sing	_	_	_	_
33	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7324
# text = ALD-induced calcium mobilization and PKC activation are independent of tyrosine protein kinase activity as shown by the lack of effect of herbimycin, a tyrosine-protein kinase-specific inhibitor.
1	ALD	ALd	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
5	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7325
# text = Although we detected no IL-2 mRNA in ALD-treated cells, the nuclei of these cells contain proteins capable of binding to three regulatory sequences in the IL-2 promoter region:
1	Although	although	SCONJ	IN	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
23	of	of	SCONJ	IN	_	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	three	three	NUM	CD	NumType=Card	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 7326
# text = NFAT, NF kappa B, and AP-1.
1	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7327
# text = These binding activities are expressed only in activated T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
3	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7328
# text = The expression of AP-1 depended on calcium mobilization and PKC activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	depended	depend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
10	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7329
# text = These data suggest that ALD cause transient but significant changes in T cell transmembrane signaling, although some events induced by stimulation with anti-CD3 antibodies are not induced by ALD.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	ALD	Ald	AUX	MD	VerbForm=Fin	_	_	_	_
6	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
7	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
15	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	although	although	SCONJ	IN	_	_	_	_	_
18	some	some	DET	DT	_	_	_	_	_
19	events	event	NOUN	NNS	Number=Plur	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
25	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	ALD	ALD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7330
# text = The signal is transmitted to the nucleus and induces DNA-binding activity by several transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	transmitted	transmit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7331
# text = However, the ALD stimulus is not capable of causing complete T cell activation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ALD	Ald	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
11	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7332
# text = Document 0030011069 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011069	0030011069	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7333
# text = Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
15	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7334
# text = Stat (signal transducers and activators of transcription) and Jak (Janus kinases) proteins are central components in the signal transduction events in hematopoietic and epithelial cells.
1	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	signal	signal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
14	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
19	components	component	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
23	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7335
# text = They are rapidly activated by various cytokines, hormones, and growth factors.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	rapidly	rapidly	ADV	RB	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7336
# text = Upon ligand binding and cytokine receptor dimerization,
1	Upon	upon	ADP	IN	_	_	_	_	_
2	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 7337
# text = Stat proteins are phosphorylated on tyrosine residues by Jak kinases.
1	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
10	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7338
# text = Activated
1	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 7339
# text = Stat proteins form homo- or heterodimers, translocate to the nucleus, and induce transcription from responsive genes.
1	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
2	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	_
4	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	translocate	translocate	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7340
# text = Stat5 and Stat6 are transcription factors active in mammary epithelial cells and immune cells.
1	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
10	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7341
# text = Prolactin activates Stat5, and interleukin-4 (IL-4) activates Stat6.
1	Prolactin	Prolactin	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7342
# text = Both cytokines are able to stimulate cell proliferation, differentiation, and survival.
1	Both	both	DET	DT	_	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7343
# text = We investigated the transactivation potential of Stat6 and found that it is not restricted to lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7344
# text = IL-4-dependent activation of Stat6 was also observed in HC11 mammary epithelial cells.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	HC11	HC11	NUM	CD	NumType=Card	_	_	_	_
14	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
15	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7345
# text = In these cells, Stat6 activation led to the induction of the beta-casein gene promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Stat6	Stat6	NUM	CD	NumType=Card	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7346
# text = The induction of this promoter was confirmed in COS7 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	COS7	COS7	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7347
# text = The glucocorticoid receptor was able to further enhance IL-4-induced gene transcription through the action of Stat6.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	further	further	VERB	VB	VerbForm=Inf	_	_	_	_
8	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	action	action	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7348
# text = Deletion analysis of the carboxyl-terminal region of Stat6 and recombination of this region with a heterologous DNA binding domain allowed the delimitation and characterization of the transactivation domain of Stat6.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Stat6	stat6	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	delimitation	delimitation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
30	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Stat6	Stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7349
# text = The potencies of the transactivation domains of Stat5, Stat6, and viral protein VP16 were compared.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	potencies	potency	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
6	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	VP	vp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	16	16	NUM	CD	NumType=Card	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7350
# text = Stat6 had a transactivation domain which was about 10-fold stronger than that of Stat5.
1	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	about	about	ADP	IN	_	_	_	_	_
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
12	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
13	than	than	ADP	IN	_	_	_	_	_
14	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7351
# text = In pre-B cells (Ba/F3), the transactivation domain of Stat6 was IL-4 regulated, independently from its DNA binding function.
1	In	in	ADP	IN	_	_	_	_	_
2	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
3	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Ba/	Ba/	SYM	NFP	_	_	_	_	SpaceAfter=No
7	F3	F3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	independently	independently	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7352
# text = Document 0030011070 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011070	0030011070	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7353
# text = Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
26	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	_
27	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7354
# text = A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	obstacle	obstacle	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	SCONJ	IN	_	_	_	_	_
5	understanding	understande	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	follow	follow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
14	arises	arise	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
20	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	costimulus	costimulus	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	TCR	Tcr	VERB	VB	VerbForm=Inf	_	_	_	_
26	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	making	make	VERB	VBG	VerbForm=Ger	_	_	_	_
29	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
30	difficult	difficult	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
35	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
38	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
39	as	as	ADV	RB	_	_	_	_	_
40	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7355
# text = To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation.
1	To	to	PART	TO	_	_	_	_	_
2	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	problem	problem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	exploited	exploite	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	via	via	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
30	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
35	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	observe	observe	VERB	VB	VerbForm=Inf	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	response	response	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7356
# text = Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	B7	B7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	measurable	measurable	ADJ	JJ	Degree=Pos	_	_	_	_
29	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7357
# text = However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
9	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	B7	B7	NUM	CD	NumType=Card	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	X	LS	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	ADV	RB	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7358
# text = In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	superantigen	superantigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	either	either	CCONJ	CC	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	without	without	ADP	IN	_	_	_	_	_
19	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
20	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	as	as	ADV	RB	_	_	_	_	_
40	well	well	ADV	RB	Degree=Pos	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7359
# text = Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-mediated	-mediated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7360
# text = This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	chloroquine	chloroquine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
17	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	wortmannin	wortmannin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7361
# text = In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	wortmannin	wortmannin	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	variably	variably	ADV	RB	_	_	_	_	_
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	chloroquine	chloroquine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7362
# text = These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	part	part	NOUN	NN	Number=Sing	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	both	both	DET	DT	_	_	_	_	_
38	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
39	sphingomyelinase	sphingomyelinase	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
42	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7363
# text = Document 0030011072 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011072	0030011072	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7364
# text = Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.
1	Different	different	ADJ	JJ	Degree=Pos	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7365
# text = The lineage-restricted transcription factor GATA-1 is required for differentiation of erythroid and megakaryocytic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7366
# text = We have localized a 317 base pair cis-acting regulatory element, HS I, associated with a hematopoietic-specific
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	317	317	NUM	CD	NumType=Card	_	_	_	_
6	base	base	NOUN	NN	Number=Sing	_	_	_	_
7	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
8	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	HS	HS	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 7367
# text = DNase I hypersensitive site, which lies approx.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	approx	approx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7368
# text = 3.7 kilobases upstream of the murine hematopoietic-specific GATA-1 IE promoter.
1	3.7	3.7	NUM	CD	NumType=Card	_	_	_	_
2	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
3	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	IE	ie	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7369
# text = HS I directs high-level expression of reporter GATA-1/lacZ genes to primitive and definitive erythroid cells and megakaryocytes in transgenic mice.
1	HS	h	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lacZ	lacz	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	definitive	definitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7370
# text = Comparative sequence analysis of HS I between human and mouse shows approx.
1	Comparative	Comparative	ADJ	JJ	Degree=Pos	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	human	human	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
11	shows	show	NOUN	NNS	Number=Plur	_	_	_	_
12	approx	approx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7371
# text = 63% nucleotide identity with a more conserved core of 169 base pairs (86% identity).
1	63	63	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	%	%	SYM	NN	Number=Sing	_	_	_	_
3	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
4	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	conserved	conserved	ADJ	JJ	Degree=Pos	_	_	_	_
9	core	core	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	169	169	NUM	CD	NumType=Card	_	_	_	_
12	base	base	NOUN	NN	Number=Sing	_	_	_	_
13	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	86	86	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	identity	identity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7372
# text = This core contains a GATA site separated by 10 base pairs from an E-box motif.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	core	core	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	base	base	NOUN	NN	Number=Sing	_	_	_	_
11	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	box	box	NOUN	NN	Number=Sing	_	_	_	_
16	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7373
# text = The composite motif binds a multi-protein hematopoietic-specific transcription factor complex which includes GATA-1, SCL/tal-1, E2A, Lmo2 and Ldb-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
3	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	multi-protein	multi-protein	ADJ	JJ	Degree=Pos	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	E2A	E2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Lmo2	Lmo2	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Ldb	Ldb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7374
# text = Point mutations of the GATA site abolishes HS I function, whereas mutation of the E-box motif still allows reporter gene expression in both lineages.
1	Point	point	ADJ	JJ	Degree=Pos	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	HS	H	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
19	still	still	ADV	RB	_	_	_	_	_
20	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7375
# text = Strict dependence of HS I activity on a GATA site implies that assembly of a protein complex containing a GATA-factor, presumably GATA-1 or GATA-2, is critical to activating or maintaining its function.
1	Strict	strict	ADJ	JJ	Degree=Pos	_	_	_	_
2	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
5	I	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	implies	imply	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	presumably	presumably	ADV	RB	_	_	_	_	_
25	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	SCONJ	IN	_	_	_	_	_
36	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7376
# text = Further dissection of the 317 base pair region demonstrates that, whereas all 317 base pairs are required for expression in megakaryocytes, only the 5' 62 base pairs are needed for erythroid-specific reporter expression.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	317	317	NUM	CD	NumType=Card	_	_	_	_
6	base	base	NOUN	NN	Number=Sing	_	_	_	_
7	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	ADV	RB	_	_	_	_	_
13	all	all	DET	DT	_	_	_	_	_
14	317	317	NUM	CD	NumType=Card	_	_	_	_
15	base	base	NOUN	NN	Number=Sing	_	_	_	_
16	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	'	'	PUNCT	``	_	_	_	_	_
28	62	62	NUM	CD	NumType=Card	_	_	_	_
29	base	base	NOUN	NN	Number=Sing	_	_	_	_
30	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7377
# text = These findings demonstrate differential lineage requirements for expression within the HS I element.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
5	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
6	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HS	H	PROPN	NNPS	Number=Plur	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	element	element	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7378
# text = Document 0030011074 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011074	0030011074	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7379
# text = Rescue by cytokines of apoptotic cell death induced by IL-2 deprivation of human antigen-specific
1	Rescue	rescue	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	death	death	NOUN	NN	Number=Sing	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	antigen-specific	antigen-specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 7380
# text = T cell clones.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7381
# text = The control of cell survival and cell death is of central importance in tissues with high cell turnover such as the lymphoid system.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	death	death	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7382
# text = We have examined the effect of cytokines on IL-2 deprivation-induced apoptosis of human antigen-specific T helper clones with different cytokine production profiles.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	antigen-specific	antigen-specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
21	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	_
26	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7383
# text = We found that IL-2, interferon-alpha (IFN-alpha), and IFN-beta inhibited IL-2 deprivation apoptosis in Th0, Th1, and Th2 clones.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IFN	IFN	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	_
26	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	Th0	Th0	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	Th1	Th1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
34	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7384
# text = We also found that IL-2 protects T cell clones from IL-2 deprivation apoptosis accompanying active proliferation and enhanced expression of P53, Rb and Bcl-xL proteins.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	protects	protect	NOUN	NNS	Number=Plur	_	_	_	_
9	T	t	NUM	CD	NumType=Card	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
18	accompanying	accompany	VERB	VBG	VerbForm=Ger	_	_	_	_
19	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	P53	P53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	xL	xL	PROPN	NNP	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7385
# text = In contrast, IFN-alpha/beta rescued T cell clones from apoptosis without active proliferation, and expression of apoptosis-associated proteins tested so far was unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	rescued	rescue	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
15	without	without	ADP	IN	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	so	so	ADV	RB	_	_	_	_	_
28	far	far	ADV	RB	Degree=Pos	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7386
# text = This may be due to the fact that T cells treated with IL-2 contained those located in S + G2/M phases of the cell cycle, whereas the vast majority of T cells treated with IFN-alpha/beta were located in G0/G1 phase.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	due	due	ADP	IN	_	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
18	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	S	s	PROPN	NNP	Number=Sing	_	_	_	_
21	+	+	SYM	SYM	_	_	_	_	_
22	G2/	G2/	SYM	NFP	_	_	_	_	SpaceAfter=No
23	M	m	NOUN	NN	Number=Sing	_	_	_	_
24	phases	phasis	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	whereas	whereas	SCONJ	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	vast	vast	ADJ	JJ	Degree=Pos	_	_	_	_
33	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	alpha/	alphaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
42	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	G0/G1	G0/G1	NUM	CD	NumType=Card	_	_	_	_
47	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7387
# text = IFN-alpha/beta specifically induced tyrosine phosphorylation and translocation into nucleus of signal transducers and activators of transcription (STAT) 2 protein in the T cell clones.
1	IFN-alpha/	IFN-alpha/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	beta	beof	NOUN	NN	Number=Sing	_	_	_	_
3	specifically	specifically	ADV	RB	_	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
13	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7388
# text = In addition, over-expression of STAT2 by transfection of the cDNA prevented apoptosis of the T cell clones.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	over	over	ADP	IN	_	_	_	_	SpaceAfter=No
5	-expression	-expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT2	STAT2	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
13	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7389
# text = Our present study shows that IFN-alpha and -beta mediate anti-apoptotic effect through other pathways than that of IL-2 in growth factor deprivation apoptosis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	beta	beta	ADP	IN	Abbr=Yes	_	_	_	_
12	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
13	anti-apoptotic	anti-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	_
28	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7390
# text = Document 0030011081 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011081	0030011081	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7391
# text = Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells.
1	Anti-rheumatic	Anti-rheumatic	ADJ	JJ	Degree=Pos	_	_	_	_
2	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
3	aurothioglucose	aurothioglucose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	factor-alpha-induced	factor-alpha-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	latently	latently	ADV	RB	_	_	_	_	_
14	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
15	OM	Om	ADP	IN	_	_	_	_	SpaceAfter=No
16	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Ach2	Ach2	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7392
# text = NF-kappaB is a potent cellular activator of HIV-1 gene expression.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7393
# text = Down-regulation of NF-kappaB activation is known to inhibit HIV replication from the latently infected cells.
1	Down	down	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	latently	latently	ADV	RB	Degree=Pos	_	_	_	_
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7394
# text = Gold compounds have been effectively used for many decades in the treatment of rheumatoid arthritis.
1	Gold	gold	NOUN	NN	Number=Sing	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	effectively	effectively	ADV	RB	_	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
9	decades	decade	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7395
# text = We previously reported that gold compounds, especially aurothioglucose (AuTG) containing monovalent gold ion, inhibited the DNA-binding of NF-kappaB in vitro.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	gold	gold	ADJ	JJ	Degree=Pos	_	_	_	_
6	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	especially	especially	ADV	RB	_	_	_	_	_
9	aurothioglucose	aurothioglucose	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	AuTG	AuTG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	monovalent	monovalent	ADJ	JJ	Degree=Pos	_	_	_	_
15	gold	gold	NOUN	NN	Number=Sing	_	_	_	_
16	ion	ion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7396
# text = In this report we have examined the efficacy of the gold compound AuTG as an inhibitor of HIV replication in latently infected OM10.1 and Ach2 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	gold	gold	ADJ	JJ	Degree=Pos	_	_	_	_
12	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
13	AuTG	Autg	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	latently	latently	ADV	RB	_	_	_	_	_
22	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	OM10.1	Om10.1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Ach2	ach2	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7397
# text = Tumor necrosis factor (TNF)-alpha-induced HIV-1 replication in OM10.1 or Ach2 cells was significantly inhibited by non-cytotoxic doses of AuTG (>10 microM in OM10.1 cells and >25 F.M in Ach2 cells), while 25 microM of the counter-anion thioglucose (TG) or gold compound containing divalent gold ion, HAuCl3, had no effect.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	OM10.1	OM10.1	NUM	CD	NumType=Card	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	Ach2	Ach2	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	non-cytotoxic	non-cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
25	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	AuTG	AuTG	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	>10	>10	NUM	CD	NumType=Card	_	_	_	_
30	microM	microm	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	OM	Om	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	>	>	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	25	25	NUM	CD	NumType=Card	_	_	_	_
38	F.	F.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	M	m	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	Ach2	Ach2	NUM	CD	NumType=Card	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	while	while	SCONJ	IN	_	_	_	_	_
46	25	25	NUM	CD	NumType=Card	_	_	_	_
47	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	counter-anion	counter-anion	NOUN	NN	Number=Sing	_	_	_	_
51	thioglucose	thioglucose	NOUN	NN	Number=Sing	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	TG	TG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	_
55	or	or	CCONJ	CC	_	_	_	_	_
56	gold	gold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
58	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
59	divalent	divalent	ADJ	JJ	Degree=Pos	_	_	_	_
60	gold	gold	NOUN	NN	Number=Sing	_	_	_	_
61	ion	ion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	HAuCl3	HAuCl3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
66	no	no	DET	DT	_	_	_	_	_
67	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7398
# text = The effect of AuTG on NF-kappaB-dependent gene expression was confirmed by a transient CAT assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AuTG	AuTG	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
18	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7399
# text = Specific staining as well as electron microscopic examinations revealed the accumulation of metal gold in the cells, supporting our previous hypothesis that gold ions could block NF-kappaB-DNA binding by a redox mechanism.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
3	as	as	ADV	RB	_	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	electron	electron	ADJ	JJ	Degree=Pos	_	_	_	_
7	microscopic	microscopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	examinations	examination	NOUN	NNS	Number=Plur	_	_	_	_
9	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	metal	metal	NOUN	NN	Number=Sing	_	_	_	_
14	gold	gold	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
20	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
21	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
22	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	gold	gold	ADJ	JJ	Degree=Pos	_	_	_	_
25	ions	ion	NOUN	NNS	Number=Plur	_	_	_	_
26	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
27	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
36	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7400
# text = These observations indicate that the monovalent gold compound AuTG is a potentially useful drug for the treatment of patients infected with HIV.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monovalent	monovalent	ADJ	JJ	Degree=Pos	_	_	_	_
7	gold	gold	ADJ	JJ	Degree=Pos	_	_	_	_
8	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
9	AuTG	Autg	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	potentially	potentially	ADV	RB	_	_	_	_	_
13	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
14	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7401
# text = Document 0030011088 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011088	0030011088	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7402
# text = T-lymphocytes from individuals with filarial inflammatory disease have increased transendothelial migration in vitro.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	filarial	filarial	ADJ	JJ	Degree=Pos	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7403
# text = The in vitro transendothelial migration of circulating filarial antigen-specific T-cells was examined in Wuchereria banerofti infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
4	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	filarial	filarial	ADJ	JJ	Degree=Pos	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Wuchereria	Wuchereria	PROPN	NNP	Number=Sing	_	_	_	_
17	banerofti	banerofti	NOUN	NN	Number=Sing	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7404
# text = Circulating T-cells from individuals with filaria-induced lymphatic pathology (LP) had significantly greater migration through unstimulated HUVEC monolayers than did T-cells from asymptomatic infected (MF) individuals (P = 0.04).
1	Circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	filaria	filaria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	lymphatic	lymphatic	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathology	pathology	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LP	LP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
18	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
21	HUVEC	Huvec	NOUN	NN	Number=Sing	_	_	_	_
22	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	did	do	NOUN	NN	Number=Sing	_	_	_	_
25	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	asymptomatic	asymptomatic	ADJ	JJ	Degree=Pos	_	_	_	_
29	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	MF	MF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	P	p	NOUN	NN	Number=Sing	_	_	_	_
36	=	=	SYM	SYM	_	_	_	_	_
37	0.04	0.04	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7405
# text = In contrast to the MF individuals where no effect was seen, transendothelial migration of 48-hr filarial antigen stimulated T-cells from LP individuals was significantly (P = 0.01) greater than migration of 48-hr media-stimulated T-cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MF	MF	PROPN	NNP	Number=Sing	_	_	_	_
6	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
7	where	where	ADV	WRB	PronType=Rel	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
19	filarial	filarial	ADJ	JJ	Degree=Pos	_	_	_	_
20	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	LP	Lp	NOUN	NN	Number=Sing	_	_	_	_
26	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	significantly	significantly	ADV	RB	_	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	P	p	SYM	NFP	_	_	_	_	_
31	=	=	SYM	SYM	_	_	_	_	_
32	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
35	than	than	ADP	IN	_	_	_	_	_
36	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
41	media	media	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7406
# text = In six of seven patients examined, inhibition of the VLA-4/VCAM-1 pathway resulted in greater than 50% inhibition of transendothelial migration of T-cells.
1	In	in	ADP	IN	_	_	_	_	_
2	six	six	NUM	CD	NumType=Card	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	seven	seven	NUM	CD	NumType=Card	_	_	_	_
5	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
6	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	VLA-4/	Vla-4/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7407
# text = Document 0030011090 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011090	0030011090	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7408
# text = A low NM23.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
3	NM23.	NM23.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 7409
# text = H1 gene expression identifying high malignancy human melanomas.
1	H1	H1	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	identifying	identify	VERB	VBG	VerbForm=Ger	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7410
# text = The NM23 gene has been proposed as a metastasis-suppressor gene, and its use has been suggested as prognostic factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NM23	NM23	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	metastasis	metastasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
16	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	use	use	NOUN	NN	Number=Sing	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	prognostic	prognostic	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7411
# text = NM23 was identified in a system of murine melanoma cell lines, in which an inverse relationship was found between NM23 expression and metastatic ability.
1	NM23	NM23	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	system	system	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
9	melanoma	melanoma	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	inverse	inverse	NOUN	NN	Number=Sing	_	_	_	_
17	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	between	between	ADP	IN	_	_	_	_	_
21	NM23	NM23	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7412
# text = In a human malignant melanoma study NM23 expression was found to be significantly lower in metastases that developed less than 24 months after diagnosis of the primary tumours.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
5	melanoma	melanoma	NOUN	NN	Number=Sing	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	NM23	NM23	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	24	24	NUM	CD	NumType=Card	_	_	_	_
22	months	month	NOUN	NNS	Number=Plur	_	_	_	_
23	after	after	ADP	IN	_	_	_	_	_
24	diagnosis	diagnosis	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
28	tumours	tumour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7413
# text = The present paper studies the expression of the NM23.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NM23.	NM23.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 7414
# text = H1 gene in cell lines which derive from primary or metastatic human malignant melanomas in relation to staging, infiltration degree, lymphocytic infiltration, cell morphology, cell pigmentation, karyotype, and disease-free survival.
1	H1	H1	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	derive	derive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
14	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	staging	staging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
21	degree	degree	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	pigmentation	pigmentation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	karyotype	karyotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
38	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7415
# text = The level of mRNA expression of the NM23 gene is significantly lower in cell lines that derive from more infiltrating primary melanomas than in cell lines obtained from less infiltrating tumours.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NM23	NM23	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	derive	derive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
20	infiltrating	infiltrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
22	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
27	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
30	infiltrating	infiltrat	ADJ	JJ	Degree=Pos	_	_	_	_
31	tumours	tumour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7416
# text = Moreover, cell lines derived from tumours of patients with a disease-free survival of more than 24 months (24-58 months) express the NM23 gene at higher levels than cell lines obtained from melanomas of patients with a disease-free survival of less than 24 months (6-15 months).
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	tumours	tumour	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
15	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	_
20	months	month	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	58	58	NUM	CD	NumType=Card	_	_	_	_
25	months	month	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	NM23	NM23	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
33	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
34	than	than	ADP	IN	_	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
37	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
47	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
50	than	than	ADP	IN	_	_	_	_	_
51	24	24	NUM	CD	NumType=Card	_	_	_	_
52	months	month	NOUN	NNS	Number=Plur	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
56	15	15	NUM	CD	NumType=Card	_	_	_	_
57	months	month	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7417
# text = Document 0030011093 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011093	0030011093	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7418
# text = Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine.
1	Tissue	Tissue	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	lysophosphatidylcholine	lysophosphatidylcholine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7419
# text = The expression of tissue factor (TF), the principal initiator of coagulation, is increased during inflammation and atherosclerosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	principal	principal	ADJ	JJ	Degree=Pos	_	_	_	_
12	initiator	initiator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7420
# text = Both conditions are promoted by lysophosphatidylcholine (lysoPC).
1	Both	both	DET	DT	_	_	_	_	_
2	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	lysophosphatidylcholine	lysophosphatidylcholine	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	lysoPC	lysoPC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7421
# text = We observed in the present study that lysoPC (1 to 10 micromol/L) dose-dependently reduced TF activity in human monocytes, as elicited by lipopolysaccharide (LPS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	micromol/	micromol/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	L	l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	dependently	dependently	ADV	RB	_	_	_	_	_
19	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7422
# text = Lysophosphatidylethanolamine (lysoPE) and other lysophospholipids did not affect LPS-induced TF activity of human monocytes.
1	Lysophosphatidylethanolamine	Lysophosphatidylethanolamine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	lysoPE	lysoPE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	lysophospholipids	lysophospholipid	NOUN	NNS	Number=Plur	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
11	LPS	Lps	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7423
# text = TF antigen expression as elicited by LPS was also lowered by lysoPC.
1	TF	Tf	ADP	IN	_	_	_	_	_
2	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	SCONJ	IN	_	_	_	_	_
5	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	lowered	lower	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7424
# text = Phospholipid analyses indicated a selective increase in the lysoPC content of the monocytes after preincubation with the lysophospholipid.
1	Phospholipid	Phospholipid	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	lysoPC	lysoPC	NOUN	NN	Number=Sing	_	_	_	_
10	content	content	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	lysophospholipid	lysophospholipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7425
# text = LysoPC inhibited the TF activity of Mono Mac-6 cells to a similar extent as in the monocytes.
1	LysoPC	LysoPC	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
8	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7426
# text = LPS binding to plasma membrane receptors and internalization of LPS into monocytes were not affected by lysoPC.
1	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
5	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	internalization	internalization	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	lysoPC	lysoPC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7427
# text = In contrast, LPS-mediated nuclear binding of nuclear factor-kappaB/Rel to a TF-specific kappaB site was inhibited by lysoPC.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7428
# text = Induction of TF mRNA expression by LPS tended to be partially reduced by the lysophospholipid.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
8	tended	tend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	partially	partially	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	lysophospholipid	lysophospholipid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7429
# text = Preincubation with lysoPC increased monocytic cAMP levels.
1	Preincubation	Preincubation	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7430
# text = Inhibition of adenylyl cyclase by pretreatment with 2'-deoxy-3'-adenosine monophosphate partially reversed the inhibition of TF activity promoted by lysoPC.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	adenylyl	adenylyl	ADJ	JJ	Degree=Pos	_	_	_	_
4	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	deoxy	deoxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
15	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
16	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
17	partially	partially	ADV	RB	_	_	_	_	_
18	reversed	reverse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7431
# text = In conclusion, lysoPC markedly decreases LPS-mediated TF expression of human monocytes, the effect probably being mediated by both transcriptional and posttranscriptional mechanisms.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	lysoPC	lysoPC	PROPN	NNP	Number=Sing	_	_	_	_
5	markedly	markedly	ADV	RB	_	_	_	_	_
6	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	probably	probably	ADV	RB	_	_	_	_	_
19	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7432
# text = LysoPC may thus attenuate activation of coagulation during inflammation and atherosclerosis.
1	LysoPC	Lysopc	NOUN	NN	Number=Sing	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	attenuate	attenuate	VERB	VB	VerbForm=Inf	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7433
# text = Document 0030011094 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011094	0030011094	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7434
# text = IL-2-independent activation and proliferation in human T cells induced by CD28.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7435
# text = Although the role of CD28 in T cell costimulation is firmly established, the mechanisms by which it exerts its costimulatory actions are less clear.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	firmly	firmly	ADV	RB	_	_	_	_	_
12	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
25	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7436
# text = In many circumstances it is difficult to distinguish the effects of CD28 from subsequent actions of cytokines, such as IL-2, on T cell proliferation.
1	In	in	ADP	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	circumstances	circumstance	NOUN	NNS	Number=Plur	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	difficult	difficult	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	distinguish	distinguish	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
15	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7437
# text = Here, we report a model of CD28 costimulation using PMA plus the natural ligand CD80 that resulted in very limited stimulation of IL-2, as evidenced by both cytokine production and IL-2 promoter stimulation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	model	model	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
9	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
10	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
11	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
12	plus	plus	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
15	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
16	CD80	CD80	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	very	very	ADV	RB	_	_	_	_	_
21	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	as	as	SCONJ	IN	_	_	_	_	_
29	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	production	production	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7438
# text = Promoter assays revealed CD28-dependent effects on both NF-kappaB and AP-1, but not on NF-AT or the intact IL-2 promoter.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	CD28	CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7439
# text = In addition, T cell proliferation was completely resistant to the actions of the immunosuppressant cyclosporin A (CsA).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	t	NUM	CD	NumType=Card	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
16	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
17	A	A	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7440
# text = Moreover T cell proliferation was unaffected by the addition of blocking Abs to both IL-2 and the IL-2 receptor, demonstrating that this form of costimulation by CD28 was independent of IL-2.
1	Moreover	moreover	PROPN	NNP	Number=Sing	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	unaffected	unaffect	ADJ	JJ	Degree=Pos	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
12	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	form	form	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7441
# text = We also investigated the effects of stimulating T cell blasts with CD80 alone and found that there was a limited requirement for IL-2 in this system.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	_
13	alone	alone	ADV	RB	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	there	there	PRON	EX	_	_	_	_	_
18	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
21	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7442
# text = We conclude that CD28 costimulation can cause substantial T cell proliferation in the absence of IL-2, which is driven by a soluble factor independent of NF-AT transactivation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
5	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
8	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	AT	at	ADP	IN	_	_	_	_	_
32	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7443
# text = Document 0030011097 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011097	0030011097	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7444
# text = Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7445
# text = The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	assembled	assemble	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	pre-existing	pre-existing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cell	cell	ADV	RB	Degree=Pos	_	_	_	_
30	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
36	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
37	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	component	component	NOUN	NN	Number=Sing	_	_	_	_
39	within	within	ADP	IN	_	_	_	_	_
40	30	30	NUM	CD	NumType=Card	_	_	_	_
41	min	min	NOUN	NNS	Number=Plur	_	_	_	_
42	after	after	ADP	IN	_	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	through	through	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7446
# text = Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	components	component	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	AT	AT	ADP	IN	_	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7447
# text = Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos).
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	component	component	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	AT	at	PRON	WDT	PronType=Rel	_	_	_	_
14	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7448
# text = We further characterize which AP1 family members can assume this role.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	characterize	characterize	NOUN	NN	Number=Sing	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	members	member	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	assume	assume	VERB	VB	VerbForm=Inf	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7449
# text = Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1.
1	Antisera	Antisera	PROPN	NNP	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
4	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7450
# text = Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
12	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
13	Fra	Fra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	eliminates	eliminate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
21	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
24	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
26	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	leaving	leave	VERB	VBG	VerbForm=Ger	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	calcium	calcium	VERB	VB	VerbForm=Inf	_	_	_	_
42	ionophore	ionophore	ADV	RB	_	_	_	_	_
43	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7451
# text = Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cJun	cJun	PROPN	NNP	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	eliminates	eliminate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	ADV	RB	_	_	_	_	_
23	all	all	DET	DT	_	_	_	_	_
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	functionally	functionally	ADV	RB	_	_	_	_	_
32	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	AT	AT	ADV	RB	_	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
45	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7452
# text = NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes.
1	NF	Nf	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	semi-purified	semi-purified	ADJ	JJ	Degree=Pos	_	_	_	_
13	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7453
# text = Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex.
1	Fos	Fo	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	although	although	SCONJ	IN	_	_	_	_	_
12	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	AT	at	NOUN	NN	Number=Sing	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7454
# text = Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	partially	partially	ADV	RB	_	_	_	_	_
6	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	elution	elution	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	renaturation	renaturation	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	SDS	SDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	electrophoresis	electrophoresis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	gels	gel	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
29	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
32	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
33	between	between	ADP	IN	_	_	_	_	_
34	94	94	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	116	116	NUM	CD	NumType=Card	_	_	_	_
37	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
41	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
42	differentially	differentially	ADV	RB	_	_	_	_	_
43	modified	modified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	forms	form	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7455
# text = Document 0030011099 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011099	0030011099	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7456
# text = Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor.
1	Amelioration	Amelioration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
4	cerulein	cerulein	NOUN	NN	Number=Sing	_	_	_	_
5	pancreatitis	pancreatitis	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	guamerin	guamerin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
14	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7457
# text = Increased activity of various proteases is observed in both human and experimental pancreatitis; however, the information on the effects of specific protease inhibitors on the disease is limited.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
5	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
13	pancreatitis	pancreatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	information	information	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
25	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7458
# text = In this study we show that a novel elastase inhibitor, guamerin-derived synthetic peptide (GDSP), improves the parameters of cerulein-induced acute pancreatitis in the rat.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	guamerin	guamerin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
16	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	GDSP	GDSP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	improves	improve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cerulein-	cerulein-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
28	pancreatitis	pancreatitis	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	rat	rat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7459
# text = The effects of GDSP on pancreatic weight, serum amylase and lipase, morphologic changes in the pancreas, neutrophil infiltration, and nuclear factor KB (NF-KB) activation were measured in rats infused with supramaximal dose of cerulein (5 (g/kg/h) for 6 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GDSP	GDSP	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
7	weight	weight	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
10	amylase	amylase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	lipase	lipase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	morphologic	morphologic	ADJ	JJ	Degree=Pos	_	_	_	_
15	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pancreas	pancrea	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
21	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	KB	KB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
37	infused	infuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	supramaximal	supramaximal	ADJ	JJ	Degree=Pos	_	_	_	_
40	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	cerulein	cerulein	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	5	5	NUM	CD	NumType=Card	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	g/	gith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kg	kg	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
49	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	for	for	ADP	IN	_	_	_	_	_
52	6	6	NUM	CD	NumType=Card	_	_	_	_
53	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7460
# text = The effects of GDSP were also measured on superoxide formation by activated human neutrophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GDSP	GDSP	PROPN	NNP	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	superoxide	superoxide	NOUN	NN	Number=Sing	_	_	_	_
10	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7461
# text = The effects of GDSP were compared with those of another elastase inhibitor, elastatinal.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GDSP	GDSP	PROPN	NNP	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	another	another	DET	DT	_	_	_	_	_
11	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	elastatinal	elastatinal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7462
# text = GDSP significantly inhibited edema formation, neutrophil infiltration, acinar cell damage, and plasma lipase and amylase increases caused by cerulein.
1	GDSP	GDSp	SYM	NFP	_	_	_	_	_
2	significantly	significantly	ADV	RB	_	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	edema	edema	NOUN	NN	Number=Sing	_	_	_	_
5	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
8	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	acinar	acinar	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
16	lipase	lipase	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	amylase	amylase	NOUN	NN	Number=Sing	_	_	_	_
19	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
20	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	cerulein	cerulein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7463
# text = GDSP also completely inhibited superoxide formation in the human neutrophils stimulated by N-formyl-methionine-leucine-phenyl-alanine (fMLP) or 12-O-tetradecanoylphorbol-13-acetate (TPA).
1	GDSP	GDSp	SYM	NFP	_	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	completely	completely	ADV	RB	_	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	superoxide	superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	formyl	formyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-methionine-leucine-phenyl-alanine	-methionine-leucine-phenyl-alanine	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	fMLP	fMLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7464
# text = Elastatinal had some of the same effects as GDSP but was less potent and effective.
1	Elastatinal	Elastatinal	PROPN	NNP	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	some	some	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	GDSP	GDSP	PROPN	NNP	Number=Sing	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
13	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7465
# text = These results demonstrate a beneficial effect of GDSP, a novel specific elastase inhibitor, on the development of rat cerulein pancreatitis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GDSP	GDSP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	elastase	elastase	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	development	development	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
21	cerulein	cerulein	NOUN	NN	Number=Sing	_	_	_	_
22	pancreatitis	pancreatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7466
# text = Document 0030011100 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011100	0030011100	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7467
# text = Human neutrophils express GH-N gene transcripts and the pituitary transcription factor Pit-1b.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	GH	Gh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	N	n	CCONJ	CC	Abbr=Yes	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	pituitary	pituitary	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7468
# text = Since GH stimulates the development and function of granulocytes, we investigated the expression of GH in granulocyte subsets.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	GH	GH	PROPN	NNP	Number=Sing	_	_	_	_
3	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	development	development	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	GH	Gh	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
19	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7469
# text = By immunocytochemistry, 25 +/- 7% of the human neutrophils were shown to express immunoreactive GH, whereas eosinophils were negative.
1	By	by	ADP	IN	_	_	_	_	_
2	immunocytochemistry	immunocytochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	25	25	NUM	CD	NumType=Card	_	_	_	_
5	+/-	+/-	SYM	SYM	_	_	_	_	_
6	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	%	%	SYM	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
16	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	GH	Gh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7470
# text = Reversed transcription (RT)-PCR analysis demonstrated GH mRNA in neutrophils.
1	Reversed	reversed	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	PCR	Pcr	ADJ	JJ	Degree=Pos	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	GH	Gh	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7471
# text = Restriction analysis revealed that neutrophils express the GH-N gene but not the GH-V gene.
1	Restriction	restriction	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
6	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	GH	GH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	N	N	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GH	GH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	V	V	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7472
# text = Furthermore, we demonstrated by western blot analysis that neutrophils express an alternatively spliced variant of the pituitary transcription factor Pit-1, designated Pit-1b.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	western	western	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	neutrophils	neutrophil	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	alternatively	alternatively	ADV	RB	_	_	_	_	_
14	spliced	splice	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pituitary	pituitary	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	Pit	pit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-1b	-1b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7473
# text = Document 0030011104 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011104	0030011104	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7474
# text = N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity.
1	N	not	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	MAD3/	Mad3/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7475
# text = The proteolytic degradation of the inhibitory protein MAD3/I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	MAD3/	Mad3/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	prerequisite	prerequisite	ADJ	JJ	Degree=Pos	_	_	_	_
21	step	step	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7476
# text = Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	X	GW	_	_	_	_	_
9	B	b	X	GW	_	_	_	_	_
10	alpha	alpha	X	GW	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
14	transfectants	transfectant	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
17	70Z	70Z	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
28	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	exogenous	exogenous	X	ADD	_	_	_	_	_

# sent_id = 7477
# text = I kappa
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7478
# text = B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
19	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
20	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7479
# text = In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
12	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Ac	Ac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Leu	Leu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Leu-norleucinal	Leu-norleucinal	ADJ	JJ	Degree=Pos	_	_	_	_
19	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
31	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	stabilizes	stabilize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	hyperphosphorylated	hyperphosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	form	form	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
40	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	alpha	alpha	ADP	IN	_	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7480
# text = By expressing mutant forms of the human protein in this cell line, we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha.
1	By	by	ADP	IN	_	_	_	_	_
2	expressing	express	ADJ	JJ	Degree=Pos	_	_	_	_
3	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
4	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
22	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	both	both	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B	B	PROPN	NNP	Number=Sing	_	_	_	_
37	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7481
# text = Our results show that deletion of the C terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	_
9	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	X	GW	_	_	_	_	_
14	B	benefit	X	GW	_	_	_	_	_
15	alpha	alpha	X	GW	_	_	_	_	_
16	molecule	molecule	X	GW	_	_	_	_	_
17	up	up	X	GW	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	amino	kaminow	DET	DT	_	_	_	_	_
20	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
21	279	279	NUM	CD	NumType=Card	_	_	_	_
22	abolishes	abolish	NOUN	NNS	Number=Plur	_	_	_	_
23	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	ligand	ligand	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
29	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
32	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
35	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7482
# text = Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
11	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	maps	map	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	serines	serine	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	N	N	PROPN	NNP	Number=Sing	_	_	_	_
20	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
26	32	32	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	either	either	DET	DT	_	_	_	_	_
36	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	abolish	abolish	VERB	VB	VerbForm=Inf	_	_	_	_
41	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	whereas	whereas	SCONJ	IN	_	_	_	_	_
47	both	both	DET	DT	_	_	_	_	_
48	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
49	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
50	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
51	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	to	to	PART	TO	_	_	_	_	_
53	abolish	abolish	VERB	VB	VerbForm=Inf	_	_	_	_
54	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
55	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7483
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7484
# text = Document 0030011106 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011106	0030011106	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7485
# text = Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	growth-	growth-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
7	MCM5	MCM5	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	MCM6	MCM6	PROPN	NNP	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7486
# text = Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle.
1	Initiation	Initiation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MCM	MCm	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	ensuring	ensure	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
20	occurs	occur	ADV	RB	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	once	once	ADV	RB	NumType=Mult	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7487
# text = Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	MCM	MCM	PROPN	NNP	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	unlike	unlike	ADP	IN	_	_	_	_	_
17	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
22	levels	levels	NOUN	NNS	Number=Plur	_	_	_	_
23	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	G1/S	G1/S	PROPN	NNP	Number=Sing	_	_	_	_
26	boundary	boundary	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7488
# text = In this study, we examined the transcriptional activities of isolated human MCM gene promoters.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	MCM	MCm	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7489
# text = Human MCM5 and MCM6 promoters with mutation in the E2F sites failed in promoter regulation following serum stimulation and exogenous E2F expression.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	MCM5	MCM5	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	MCM6	MCM6	NUM	CD	NumType=Card	_	_	_	_
5	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	E2	E2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	F	f	PROPN	NNP	Number=Sing	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	failed	fail	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
18	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
22	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7490
# text = In addition, we identified a novel E2F-like sequence in human MCM6 promoter which cooperates with the authentic E2F sites in E2F-dependent regulation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	E2F	E2F	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	MCM6	Mcm6	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	authentic	authentic	ADJ	JJ	Degree=Pos	_	_	_	_
21	E2	e2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	F	for	PROPN	NNP	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7491
# text = Forced expression of E2F1 could induce expression of all members of the endogenous MCM genes in rat embryonal fibroblast REF52 cells.
1	Forced	forced	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	E2F1	E2f1	PROPN	NNP	Number=Sing	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
14	MCM	MCm	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
18	embryonal	embryonal	ADV	RB	_	_	_	_	_
19	fibroblast	fibroblast	ADV	RBS	Degree=Sup	_	_	_	_
20	REF52	Ref52	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7492
# text = Our results demonstrated that the growth-regulated expression of mammalian MCM5 and MCM6 genes, and presumably other MCM members, is primarily regulated by E2F through binding to multiple E2F sites in the promoters.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
12	MCM5	Mcm5	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	MCM6	Mcm6	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	presumably	presumably	ADV	RB	_	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	MCM	MCm	NOUN	NN	Number=Sing	_	_	_	_
21	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	primarily	primarily	ADV	RB	_	_	_	_	_
25	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	_
28	through	through	SCONJ	IN	_	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	multiple	multiple	VERB	VB	VerbForm=Inf	_	_	_	_
32	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	F	f	PROPN	NNP	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7493
# text = Document 0030011110 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011110	0030011110	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7494
# text = Cyclosporin
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 7495
# text = A inhibits monocyte tissue factor activation in cardiac transplant recipients.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
3	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
9	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
10	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7496
# text = BACKGROUND: Fibrin deposition and thrombosis have been implicated in both allograft rejection and vasculopathy after cardiac transplantation.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Fibrin	Fibrin	ADJ	JJ	Degree=Pos	_	_	_	_
4	deposition	deposition	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	thrombosis	thrombosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	allograft	allograft	NOUN	NN	Number=Sing	_	_	_	_
13	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	vasculopathy	vasculopathy	NOUN	NN	Number=Sing	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
18	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7497
# text = Because monocytes play a pivotal role in the pathophysiology of intravascular coagulation activation through their ability to synthesize tissue factor (TF), we asked (1) whether monocyte TF activation occurs in cardiac transplant recipients and (2) whether monocyte TF expression is affected by treatment with cyclosporin A (CsA).
1	Because	because	SCONJ	IN	_	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	intravascular	intravascular	ADJ	JJ	Degree=Pos	_	_	_	_
12	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	synthesize	synthesize	VERB	VB	VerbForm=Inf	_	_	_	_
19	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	asked	ask	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	1	1	X	LS	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	whether	whether	SCONJ	IN	_	_	_	_	_
31	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
32	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
37	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
38	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	2	2	X	LS	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	whether	whether	SCONJ	IN	_	_	_	_	_
44	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	_
45	TF	TF	ADP	RP	_	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
53	A	a	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7498
# text = METHODS AND RESULTS:
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 7499
# text = We measured levels of TF activity in peripheral blood mononuclear cells and highly purified monocytes/macrophages from 10 consecutive cardiac transplant recipients and 10 healthy control subjects.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	10	10	NUM	CD	NumType=Card	_	_	_	_
20	consecutive	consecutive	ADJ	JJ	Degree=Pos	_	_	_	_
21	cardiac	cardiac	NOUN	NN	Number=Sing	_	_	_	_
22	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
23	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
27	control	control	NOUN	NN	Number=Sing	_	_	_	_
28	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7500
# text = TF activity generated by both unstimulated and endotoxin-stimulated cells was significantly higher in transplant recipients than in control subjects (P<.05).
1	TF	Tf	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	endotoxin-	endotoxin-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	significantly	significantly	ADV	RB	_	_	_	_	_
13	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	transplant	transplant	ADJ	JJ	Degree=Pos	_	_	_	_
16	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	.05	.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7501
# text = Increased monocyte TF expression in transplant recipients was shown to be adversely affected by treatment with CsA: TF induction was markedly reduced by CsA serum concentrations reaching peak CsA drug levels.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
3	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	transplant	transplant	ADJ	JJ	Degree=Pos	_	_	_	_
7	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	adversely	adversely	ADV	RB	_	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	TF	Tf	ADJ	JJ	Degree=Pos	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	markedly	markedly	ADV	RB	_	_	_	_	_
23	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
26	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
27	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
28	reaching	reach	VERB	VBG	VerbForm=Ger	_	_	_	_
29	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
30	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
31	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
32	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7502
# text = Inhibition of TF induction in the presence of high CsA blood concentrations was also observed when stimulation of cells was performed with interferon-gamma or interleukin-1beta.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
10	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7503
# text = As shown by reverse transcription-polymerase chain reaction and electrophoretic mobility shift assay, respectively, treatment with CsA leads to decreased TF mRNA expression and reduced activation of the NF-kappaB transcription factor, which is known to contribute to the induction of the TF promotor in human monocytes.
1	As	as	SCONJ	IN	_	_	_	_	_
2	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
13	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
14	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
21	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	decreased	decreased	VERB	VB	VerbForm=Inf	_	_	_	_
24	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
25	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
49	promotor	promotor	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
52	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7504
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 7505
# text = This study demonstrates that TF activation, occurring in mononuclear cells of cardiac transplant recipients, is inhibited by treatment with CsA.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TF	Tf	PROPN	NNP	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
14	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
15	recipients	recipient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7506
# text = Inhibition of monocyte TF induction by CsA may contribute to its successful use in cardiac transplant medicine and might be useful in managing further settings of vascular pathology also known to involve TF expression and NF-kappaB activation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
4	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	successful	successful	ADJ	JJ	Degree=Pos	_	_	_	_
13	use	use	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
16	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
17	medicine	medicine	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	managing	manag	VERB	VBG	VerbForm=Ger	_	_	_	_
24	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
25	settings	setting	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
28	pathology	pathology	NOUN	NN	Number=Sing	_	_	_	_
29	also	also	ADV	RB	_	_	_	_	_
30	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	involve	involve	ADJ	JJ	Degree=Pos	_	_	_	_
33	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
34	expression	expression	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7507
# text = Document 0030011112 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011112	0030011112	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7508
# text = c-Maf induces monocytic differentiation and apoptosis in bipotent myeloid progenitors.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Maf	Maf	NOUN	NN	Number=Sing	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	bipotent	bipotent	ADJ	JJ	Degree=Pos	_	_	_	_
11	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
12	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7509
# text = The transcriptional mechanisms that drive colony-forming unit granulocyte-macrophage (CFU-GM) myeloid progenitors to differentiate into cells of either the granulocytic or monocytic lineage are not fully understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	drive	drive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
9	unit	unit	NOUN	NN	Number=Sing	_	_	_	_
10	granulocyte-	granulocyte-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CFU	CFU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
18	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	either	either	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	fully	fully	ADV	RB	_	_	_	_	_
33	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7510
# text = We have shown that the c-Maf and c-Myb transcription factors physically interact in myeloid cells to form inhibitory complexes that hinder transactivation of c-Myb target genes through direct binding to Myb consensus sites.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Maf	Maf	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	physically	physically	ADV	RB	_	_	_	_	_
16	interact	interact	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
22	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
23	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	hinder	hinder	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
31	target	target	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
33	through	through	ADP	IN	_	_	_	_	_
34	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
38	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7511
# text = These complexes arise in a developmentally regulated pattern, peaking at the promyelocyte stage, or in cell model systems, appearing soon after the induction of monocytic differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	arise	arise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	developmentally	developmentally	ADV	RB	_	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
14	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	model	model	NOUN	NN	Number=Sing	_	_	_	_
20	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	appearing	appear	VERB	VBG	VerbForm=Ger	_	_	_	_
23	soon	soon	ADV	RB	Degree=Pos	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7512
# text = We wished to determine if this developmentally related interaction is a consequence of myeloid differentiation or an intrinsic differentiating stimulus.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	wished	wish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	if	if	SCONJ	IN	_	_	_	_	_
6	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	developmentally	developmentally	ADV	RB	_	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiating	differentiating	NOUN	NN	Number=Sing	_	_	_	_
20	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7513
# text = Because the elevated Myb:Maf status seen in differentiating cells can be recapitulated by overexpression of c-Maf in myeloid cell lines, we inducibly expressed the c-Maf cDNA in 2 bipotent human myeloid progenitor cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
6	Maf	Maf	ADJ	JJ	Degree=Pos	_	_	_	_
7	status	status	NOUN	NN	Number=Sing	_	_	_	_
8	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	differentiating	differentiating	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	recapitulated	recapitulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Maf	Maf	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
27	inducibly	inducibly	ADV	RB	_	_	_	_	_
28	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	Maf	Maf	PROPN	NNP	Number=Sing	_	_	_	_
32	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	bipotent	bipotent	ADJ	JJ	Degree=Pos	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
38	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7514
# text = Elevated levels of c-Maf protein led to marked increases in Myb:Maf complexes and the accumulation of monocyte/macrophage cells, followed by eventual programmed cell death.
1	Elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Maf	Maf	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
15	Maf	Maf	ADJ	JJ	Degree=Pos	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	eventual	eventual	ADJ	JJ	Degree=Pos	_	_	_	_
29	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7515
# text = Analysis of targets that could mediate these phenotypic changes indicated that c-Maf likely plays a key role in myeloid cell development through dual mechanisms; inhibition of a select set of c-Myb regulated targets, such as Bcl-2 and CD13/APN, coupled with the activation of as yet undefined differentiation-promoting genes.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
9	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
10	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Maf	Maf	PROPN	NNP	Number=Sing	_	_	_	_
14	likely	likely	ADV	RB	_	_	_	_	_
15	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	select	select	ADJ	JJ	Degree=Pos	_	_	_	_
31	set	set	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
40	as	as	ADP	IN	_	_	_	_	_
41	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	13/	13ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
47	APN	APN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	with	with	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	as	as	SCONJ	IN	_	_	_	_	_
55	yet	yet	ADV	RB	_	_	_	_	_
56	undefined	undefin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
60	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7516
# text = Document 0030011114 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011114	0030011114	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7517
# text = Activation of transcription factor NF-kappa B by phagocytic stimuli in human neutrophils.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	phagocytic	phagocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7518
# text = Phagocytosis represents an important physiological trigger for the inducible expression of several genes in human neutrophils.
1	Phagocytosis	Phagocytosis	PROPN	NNP	Number=Sing	_	_	_	_
2	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7519
# text = Here, we report that a DNA-binding activity primarily consisting of the classical NF-kappa B heterodimer, p50/RelA, is induced in phagocytosing neutrophils.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	primarily	primarily	ADV	RB	_	_	_	_	_
12	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	phagocytosing	phagocytose	VERB	VBG	VerbForm=Ger	_	_	_	_
30	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7520
# text = Under these conditions, NF-kappa B activation was found to be a rapid and transient response, reaching a maximum by 10-15 min, and returning to near-basal levels by 30 min.
1	Under	under	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	reaching	reach	VERB	VBG	VerbForm=Ger	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	maximum	maximum	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	15	15	NUM	CD	NumType=Card	_	_	_	_
27	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	returning	return	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	near	near	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
35	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	30	30	NUM	CD	NumType=Card	_	_	_	_
38	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7521
# text = In neutrophils undergoing the phagocytosis of opsonized yeasts, the onset of NF-kappa B activation was paralleled by a decline in immunoreactive I kappa B-alpha protein levels, and the cellular
1	In	in	ADP	IN	_	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	opsonized	opsonized	ADJ	JJ	Degree=Pos	_	_	_	_
8	yeasts	yeast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	X	GW	_	_	_	_	_
27	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
28	alpha	alpha	X	GW	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7522
# text = I kappa B-alpha pool was replenished by 30 min, in agreement with our gel shift data.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	GW	_	_	_	_	_
3	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
4	alpha	alpha	X	GW	_	_	_	_	_
5	pool	pool	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	replenished	replenish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	30	30	NUM	CD	NumType=Card	_	_	_	_
10	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
16	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
17	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
18	data	data	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7523
# text = We conclude that NF-kappa B activation could constitute one of the mechanisms whereby the expression of kappa B-responsive genes is enhanced in phagocytosing neutrophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	whereby	whereby	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	phagocytosing	phagocytose	VERB	VBG	VerbForm=Ger	_	_	_	_
28	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7524
# text = To our knowledge, this represents the first demonstration that phagocytic stimuli can induce NF-kappa B activation in human neutrophils.
1	To	to	ADP	IN	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	knowledge	knowledge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	phagocytic	phagocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7525
# text = Document 0030011122 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011122	0030011122	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7526
# text = Binding of erythroid and non-erythroid nuclear proteins to the silencer of the human epsilon-globin-encoding gene.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7527
# text = To clarify the molecular mechanisms involved in the developmental control of hemoglobin-encoding genes we have been studying the expression of these genes in human cells in continuous culture.
1	To	to	PART	TO	_	_	_	_	_
2	clarify	clarify	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	studying	study	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
30	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7528
# text = We have previously reported the presence of a transcriptional control element with the properties of a silencer extending from -392 to -177 bp relative to the cap site of the human epsilon-globin-encoding gene [Cao et al.,
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
18	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	-392	-392	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	177	177	NUM	CD	NumType=Card	_	_	_	_
24	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
25	relative	relative	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	encoding	encoding	NOUN	NN	Number=Sing	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	Cao	Cao	PROPN	NNP	Number=Sing	_	_	_	_
41	et	et	X	FW	_	_	_	_	_
42	al.	al.	X	FW	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 7529
# text = Proc.Natl.Acad.Sci.USA 86 (1989) 5306-5309].
1	Proc.Natl.Acad.Sci.USA	Proc.Natl.Acad.Sci.USA	PROPN	NNP	Number=Sing	_	_	_	_
2	86	86	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	1989	1989	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	5306	5306	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	5309	5309	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7530
# text = We also showed that this silencer has stronger inhibitory activity in HeLa cells, as compared to K562 human erythroleukemia cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
9	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	K562	K562	NUM	CD	NumType=Card	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7531
# text = Using deletion mutants and cis-cloned synthetic oligodeoxyribonucleotides in transient expression assays, nucleotide sequences responsible for this effect have now been further delimited to 44 bp located from -294 to -251 bp.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
9	oligodeoxyribonucleotides	oligodeoxyribonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	now	now	ADV	RB	_	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	further	further	ADV	RB	_	_	_	_	_
25	delimited	delimit	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	44	44	NUM	CD	NumType=Card	_	_	_	_
28	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
29	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	294	294	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	251	251	NUM	CD	NumType=Card	_	_	_	_
36	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7532
# text = Gel electrophoresis mobility shift assays and DNaseI footprinting assays demonstrate that these negative regulatory sequences are recognized differently by proteins present in nuclear extracts obtained from HeLa and K562 cells.
1	Gel	gel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	electrophoresis	electrophoresis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	DNaseI	DNaseI	NOUN	NNS	Number=Plur	_	_	_	_
8	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
9	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
10	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	differently	differently	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
25	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	K562	K562	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7533
# text = Two binding proteins are detected in K562 nuclear extracts, while only one is found in extracts from HeLa cells.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	K562	K562	NUM	CD	NumType=Card	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	while	while	SCONJ	IN	_	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7534
# text = Possible mechanisms by which these proteins may regulate transcription of the epsilon-globin-encoding gene in erythroid and non-erythroid cells are discussed.
1	Possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	globin-encoding	globin-encoding	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7535
# text = Document 0030011124 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011124	0030011124	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7536
# text = cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.
1	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
2	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	nur77-related	nur77-related	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7537
# text = A human T lymphoid cell line, PEER, dies by apoptosis in the presence of PMA and calcium ionophore.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	PEER	peer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	dies	die	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	calcium	calcium	PROPN	NNP	Number=Sing	_	_	_	_
20	ionophore	ionophore	ADV	RB	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7538
# text = A new gene, TINUR, was cloned from apoptotic PEER cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	TINUR	Tinur	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	PEER	peer	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7539
# text = The expression of the TINUR gene is induced within 1 h after the cross-linking of the T cell
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TINUR	TINUR	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7540
# text = Ag receptor complex.
1	Ag	ag	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7541
# text = TINUR belongs to the NGFI-B/nur77 family of the steroid receptor superfamily and is an orphan receptor.
1	TINUR	Tinur	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	belongs	belong	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NGFI	Ngfi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	nur77	nur77	NUM	CD	NumType=Card	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	superfamily	superfamily	ADV	RB	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7542
# text = TINUR binds to the same DNA sequence as NGFI-B/nur77.
1	TINUR	Tinur	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	nur77	nur77	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7543
# text = We also propose that the NGFI-B/nur77 family can be classified into two subtypes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NGFI	Ngfi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	nur77	nur77	NUM	CD	NumType=Card	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	classified	classify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	subtypes	subtype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7544
# text = Document 0030011128 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011128	0030011128	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7545
# text = Constitutive nuclear NF-kappa B in cells of the monocyte lineage.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7546
# text = In monocytes, the nuclear factor NF-kappa B has been invoked as an important transcription factor in the expression of cytokine genes, of cell-surface receptors and in the expression of human immunodeficiency virus.
1	In	in	ADP	IN	_	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	invoked	invok	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
30	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
38	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7547
# text = In such cells, DNA binding activity of NF-kappa B can be detected without intentional stimulation.
1	In	in	ADP	IN	_	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	without	without	ADP	IN	_	_	_	_	_
17	intentional	intentional	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7548
# text = In our studies, cells of the human monocytic line Mono Mac 6, cultured in medium containing fetal-calf serum and low levels of lipopolysaccharide (LPS), also exhibit such 'constitutive' NF-kappa B, as demonstrated by mobility-shift analysis of nuclear extracts.
1	In	in	ADP	IN	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
12	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	medium	medium	ADJ	JJ	Degree=Pos	_	_	_	_
18	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	calf	calf	NOUN	NN	Number=Sing	_	_	_	_
22	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	exhibit	exhibit	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
36	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	'	'	PUNCT	''	_	_	_	_	_
38	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	as	as	SCONJ	IN	_	_	_	_	_
44	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
49	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
52	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7549
# text = This nuclear NF-kappa B was still present when contaminant LPS was removed by ultrafiltration and when serum was omitted.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	still	still	ADV	RB	_	_	_	_	_
9	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	contaminant	contaminant	ADJ	JJ	Degree=Pos	_	_	_	_
12	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	removed	remove	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	ultrafiltration	ultrafiltration	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	omitted	omit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7550
# text = Protein-DNA complexes of constitutive NF-kappa B are similar in mobility to the LPS-induced NF-kappa B and both are recognized by an antibody specific to the p50 subunit of NF-kappa B.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
35	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7551
# text = By contrast, treatment of cells with pyrrolidine dithiocarbamate (PDTC) will only block LPS-induced NF-kappa B, but not the constitutive binding protein.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
9	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
16	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7552
# text = Using LPS-free and serum-free conditions, constitutive NF-kappa B can be detected in different cell lines of the monocytic lineage (HL60, U937, THP-1, Mono Mac 1 and Mono Mac 6), but not in Molt 4 T cells or K562 stem cells.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	LPS	Lps	ADV	RB	_	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	serum-	serum-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
8	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	HL60	HL60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
36	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
40	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
41	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	but	but	CCONJ	CC	_	_	_	_	_
45	not	not	ADV	RB	_	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	Molt	Molt	PROPN	NNP	Number=Sing	_	_	_	_
48	4	4	NUM	CD	NumType=Card	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	or	or	CCONJ	CC	_	_	_	_	_
52	K562	K562	NUM	CD	NumType=Card	_	_	_	_
53	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7553
# text = When ordered according to stage of maturation, the amount of constitutive NF-kappa B was not increased in more mature cell lines.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	ordered	order	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	according	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
22	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7554
# text = Furthermore, when inducing differentiation in Mono Mac 6 cells, with vitamin D3, no change in constitutive or inducible NF-kappa B can be detected.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
8	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
14	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	no	no	DET	DT	_	_	_	_	_
17	change	change	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7555
# text = Analysis of primary cells revealed substantial constitutive NF-kappa B-binding activity in blood monocytes, pleural macrophages and alveolar macrophages.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	pleural	pleural	ADJ	JJ	Degree=Pos	_	_	_	_
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
22	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7556
# text = The constitutive NF-kappa B appears to be functionally active, since a low level of tumour necrosis factor (TNF) transcript is detectable in monocytes, and this level can be increased by blocking transcript degradation using cycloheximide.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	functionally	functionally	ADV	RB	_	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
19	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	SCONJ	IN	_	_	_	_	_
37	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
38	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
39	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
40	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
41	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7557
# text = The level of constitutive NF-kappa B in these cells is variable and is frequently found to be lower in the more mature macrophages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	frequently	frequently	ADV	RB	_	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	more	more	ADV	RBR	_	_	_	_	_
24	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
25	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7558
# text = Constitutive NF-kappa B was not maintained by autocrine action of cytokines TNF, interleukin 6, interleukin 10, granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor, since neutralizing antibodies did not reduce constitutive DNA-binding activity.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
11	action	action	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
14	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
17	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
20	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
25	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
31	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	since	since	SCONJ	IN	_	_	_	_	_
37	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_
38	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
39	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	not	not	PART	RB	_	_	_	_	_
41	reduce	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
42	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
43	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7559
# text = Furthermore, blockade of prostaglandin or leukotriene biosynthesis did not affect constitutive NF-kappa B. (ABSTRACT TRUNCATED AT 400 WORDS)
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	prostaglandin	prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	leukotriene	leukotriene	NOUN	NN	Number=Sing	_	_	_	_
8	biosynthesis	biosynthesis	NOUN	NN	Number=Sing	_	_	_	_
9	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
12	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	ABSTRACT	Abstract	ADV	RB	_	_	_	_	_
20	TRUNCATED	tRUNCATEd	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
21	AT	at	ADV	RB	_	_	_	_	_
22	400	400	NUM	CD	NumType=Card	_	_	_	_
23	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7560
# text = Document 0030011130 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011130	0030011130	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7561
# text = In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
3	anergized	anergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
9	perturbed	pertur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7562
# text = Anergy is a major mechanism to ensure antigen-specific tolerance in T lymphocytes in the adult.
1	Anergy	Anergy	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	ensure	ensure	VERB	VB	VerbForm=Inf	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	adult	adult	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7563
# text = In vivo, anergy has mainly been studied at the cellular level.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	mainly	mainly	ADV	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7564
# text = In this study, we used the T-cell-activating superantigen staphylococcal enterotoxin A (SEA) to investigate molecular mechanisms of T-lymphocyte anergy in vivo.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activating	activate	NOUN	NN	Number=Sing	_	_	_	_
12	superantigen	superantigen	NOUN	NN	Number=Sing	_	_	_	_
13	staphylococcal	staphylococcal	NOUN	NN	Number=Sing	_	_	_	_
14	enterotoxin	enterotoxin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	SEA	Sea	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
26	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7565
# text = Injection of SEA to adult mice activates CD4+ T cells expressing certain T-cell receptor (TCR) variable region beta-chain families and induces strong and rapid production of interleukin 2 (IL-2).
1	Injection	injection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	SEA	Sea	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	adult	adult	VERB	VB	VerbForm=Inf	_	_	_	_
6	mice	mouse	NOUN	NN	Number=Sing	_	_	_	_
7	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
8	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	T	t	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
13	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	families	family	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
28	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
31	production	production	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7566
# text = In contrast, repeated injections of SEA cause CD4+ T-cell deletion and anergy in the remaining CD4+ T cells, characterized by reduced expression of IL-2 at mRNA and protein levels.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	repeated	repeat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	injections	injection	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	SEA	Sea	NOUN	NN	Number=Sing	_	_	_	_
8	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
9	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T-	T-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	remaining	remaining	ADJ	JJ	Degree=Pos	_	_	_	_
19	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7567
# text = We analyzed expression of AP-1, NF-kappa B, NF-AT, and octamer binding transcription factors, which are known to be involved in the regulation of IL-2 gene promoter activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	octamer	octamer	ADV	RBR	Degree=Cmp	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7568
# text = Large amounts of AP-1 and NF-kappa B and significant quantities of NF-AT were induced in SEA-activated CD4+ spleen T cells, whereas Oct-1 and Oct-2 DNA binding activity was similar in both resting and activated T cells.
1	Large	large	ADJ	JJ	Degree=Pos	_	_	_	_
2	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	quantities	quantity	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	AT	AT	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	SEA	sea	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	spleen	spleen	NUM	CD	NumType=Card	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	both	both	DET	DT	_	_	_	_	_
46	resting	resting	NOUN	NN	Number=Sing	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7569
# text = In contrast, anergic CD4+
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
5	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 7570
# text = T cells contained severely reduced levels of AP-1 and Fos/Jun-containing NF-AT complexes but expressed significant amounts of NF-kappa B and Oct binding proteins after SEA stimulation.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	severely	severely	ADV	RB	_	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Jun-containing	Jun-contain	PROPN	NNP	Number=Sing	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
18	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	B	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	after	after	ADP	IN	_	_	_	_	_
33	SEA	Sea	NOUN	NN	Number=Sing	_	_	_	_
34	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7571
# text = Resolution of the NF-kappa B complex demonstrated predominant expression of p50-p65 heterodimers in activated CD4+ T cells, while anergic cells mainly expressed the transcriptionally inactive p50 homodimer.
1	Resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	SYM	SYM	_	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	p65	p65	NUM	CD	NumType=Card	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	while	while	SCONJ	IN	_	_	_	_	_
25	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	mainly	mainly	ADV	RB	_	_	_	_	_
28	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
31	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
32	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
33	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7572
# text = These alterations of transcription factors are likely to be responsible for repression of IL-2 in anergic T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7573
# text = Document 0030011132 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011132	0030011132	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7574
# text = A novel SP-1 site in the human interleukin-1 beta promoter confers preferential transcriptional activity in keratinocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
16	preferential	preferential	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	keratinocytes	keratinocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7575
# text = To investigate the mechanisms of transcriptional activation of interleukin-1beta (IL-1beta) in non-monocytic cells, we constructed a series of reporter plasmids with the bacterial chloramphenicol acetyltransferase gene linked to various parts of the human IL-1beta promoter and performed transient transfection experiments.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	non-monocytic	non-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	constructed	construct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	series	series	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
29	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
33	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
34	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
39	parts	part	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
47	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
50	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
51	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
52	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7576
# text = We identified a promoter segment that activates transcription most efficiently in keratinocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	most	most	ADV	RBS	_	_	_	_	_
10	efficiently	efficiently	ADV	RB	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	keratinocytes	keratinocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7577
# text = Electrophoretic mobility shift assays (EMSA) with a 43-mer oligonucleotide derived from the functionally identified cis-acting element revealed specific complexes.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	43	43	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mer	mer	NOUN	NN	Number=Sing	_	_	_	_
13	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	functionally	functionally	ADV	RB	_	_	_	_	_
18	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cis-acting	cis-act	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7578
# text = By competition analysis with transcription factor consensus sequence oligonucleotides and by immunosupershift, transcription factor SP-1 or a closely related protein was shown to bind to this regulatory element.
1	By	by	ADP	IN	_	_	_	_	_
2	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	immunosupershift	immunosupershift	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	closely	closely	ADV	RB	_	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7579
# text = The closest match to the known SP-1 consensus sequence within the respective region is a TCCCCTCCCCT motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	closest	closest	ADJ	JJS	Degree=Sup	_	_	_	_
3	match	match	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	TCCCCTCCCCT	Tcccctcccct	NOUN	NN	Number=Sing	_	_	_	_
19	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7580
# text = Mutation of this motif almost completely, and specifically, abolished the binding of two low-mobility complexes and led to a 95% decrease of constitutive transcriptional activation of a reporter construct IL-1beta (-170/+108).
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
5	almost	almost	ADV	RB	_	_	_	_	_
6	completely	completely	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	specifically	specifically	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
19	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	%	%	SYM	NN	Number=Sing	_	_	_	_
26	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
35	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
39	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
40	170	170	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	/+	/+	SYM	SYM	_	_	_	_	SpaceAfter=No
42	108	108	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7581
# text = Likewise, activation of this reporter construct by tumor necrosis factor-alpha depended on the SP-1 site.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
7	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor-alpha	factor-alpha	NOUN	NN	Number=Sing	_	_	_	_
12	depended	depend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7582
# text = These observations suggest that a so-far-unrecognized SP-1 site in the human IL-1beta promoter may participate in the transcriptional regulation of this gene in keratinocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	far-	far-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
10	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	bet	bet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	keratinocytes	keratinocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7583
# text = Document 0030011133 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011133	0030011133	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7584
# text = Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.
1	Multifactor	Multifactor	NOUN	NN	Number=Sing	_	_	_	_
2	cis	cis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-dominant	-dominant	ADJ	JJ	Degree=Pos	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	anergized	anergized	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7585
# text = The molecular mechanism underlying IL-2 transcriptional blockade in anergic T cell clones is not fully understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	fully	fully	ADV	RB	_	_	_	_	_
18	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7586
# text = To examine whether an active negative regulatory process occurs, we created a reporter construct containing as an enhancer four copies of the NF-AT site and one copy of the octamer site (4X NF-AT-Oct).
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	process	process	NOUN	NN	Number=Sing	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	created	create	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	four	four	NUM	CD	NumType=Card	_	_	_	_
21	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	one	one	NUM	CD	NumType=Card	_	_	_	_
30	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	octamer	octamer	ADJ	JJR	Degree=Cmp	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	4X	4X	PROPN	NNP	Number=Sing	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7587
# text = This construct was only slightly reduced (1.3-fold) in its expression when stimulated under anergic conditions, while a whole mouse IL-2 enhancer construct showed a reduction of 4.3-fold.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	slightly	slightly	ADV	RB	_	_	_	_	_
6	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	1.3	1.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	under	under	ADP	IN	_	_	_	_	_
18	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
19	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	while	while	SCONJ	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
30	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	4.3	4.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7588
# text = Addition of the -176 to -96 sequence to the 4X NF-AT-Oct construct did not impart the ability to be affected by anergy, but addition of the -236 to -96 sequence did, demonstrating that anergy is an active inhibitory process and that more than the presence of the -150 AP-1 binding site (-152 to -147) is required to mediate the effect.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	176	176	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	96	96	NUM	CD	NumType=Card	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	4X	4X	PROPN	NNP	Number=Sing	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
18	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	impart	impart	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	236	236	NUM	CD	NumType=Card	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	96	96	NUM	CD	NumType=Card	_	_	_	_
39	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
40	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
43	that	that	SCONJ	IN	_	_	_	_	_
44	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
48	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
49	process	process	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	that	that	SCONJ	IN	_	_	_	_	_
52	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
53	than	than	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
59	150	150	NUM	CD	NumType=Card	_	_	_	_
60	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
62	1	1	NUM	CD	NumType=Card	_	_	_	_
63	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
64	site	site	NOUN	NN	Number=Sing	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
67	152	152	NUM	CD	NumType=Card	_	_	_	_
68	to	to	ADP	IN	_	_	_	_	_
69	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
70	147	147	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
71	)	)	PUNCT	-RRB-	_	_	_	_	_
72	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
73	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
74	to	to	PART	TO	_	_	_	_	_
75	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
76	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
77	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7589
# text = Mutational studies of the -236 to -96 sequence indicated that the presence of both the -130 AP-1-like site (-187 to -181) and the -150 proximal AP-1 site were necessary to observe anergy.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	236	236	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	96	96	NUM	CD	NumType=Card	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	130	130	NUM	CD	NumType=Card	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	187	187	NUM	CD	NumType=Card	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	181	181	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
36	150	150	NUM	CD	NumType=Card	_	_	_	_
37	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
38	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	site	site	NOUN	NN	Number=Sing	_	_	_	_
42	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
44	to	to	PART	TO	_	_	_	_	_
45	observe	observe	VERB	VB	VerbForm=Inf	_	_	_	_
46	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7590
# text = Because the -180 site is not required for trans-activation, it was possible to confirm by mutation in the normal mouse IL-2 enhancer that this site is absolutely essential for anergy induction.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	180	180	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	absolutely	absolutely	ADV	RB	_	_	_	_	_
33	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7591
# text = The simplest model to explain these results is that anergy is mediated by a complex of multiple transcription factors that exert a cis-acting dominant negative regulatory effect on the trans-activation of the IL-2 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	simplest	simplest	ADJ	JJS	Degree=Sup	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	anergy	anergy	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
26	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7592
# text = Document 0030011135 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011135	0030011135	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7593
# text = Cytokine modulation of HIV expression.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	_
2	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7594
# text = Cytokines, the peptide hormones which control the homeostasis of the immune system and also play a fundamental role in inflammatory and immune mediated reactions, have been involved at multiple levels in the pathogenesis of the acquired immune deficiency syndrome (AIDS).
1	Cytokines	Cytokine	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	peptide	peptide	ADJ	JJ	Degree=Pos	_	_	_	_
5	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	system	system	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
19	role	role	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
32	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	acquired	acquire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
40	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
41	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7595
# text = Infection with the human immunodeficiency virus (HIV) has been shown to induce production of several cytokines both in vitro and in vivo.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7596
# text = Conversely, several cytokines modulate the levels of HIV expression in infected cells of both T lymphocytic and mononuclear phagocytic lineage.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
4	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
5	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	T	T	NOUN	NN	Number=Sing	_	_	_	_
17	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	phagocytic	phagocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7597
# text = Activated mononuclear cells, particularly B cells which are in a state of chronic activation in HIV infected individuals, release HIV-inductive cytokines and thus play a potentially important role in the pathogenesis of HIV infection.
1	Activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	particularly	particularly	ADV	RB	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	state	state	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	release	release	INTJ	UH	_	_	_	_	_
22	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	inductive	inductive	ADJ	JJ	Degree=Pos	_	_	_	_
24	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	thus	thus	ADV	RB	_	_	_	_	_
27	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	potentially	potentially	ADV	RB	_	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
37	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7598
# text = Document 0030011140 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011140	0030011140	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7599
# text = An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7600
# text = The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	where	where	ADV	WRB	PronType=Rel	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7601
# text = We have cloned the mouse and human GATA-1 genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7602
# text = A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	exon	exon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	highly	highly	ADV	RB	_	_	_	_	_
11	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	man	man	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
25	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	if	if	SCONJ	IN	_	_	_	_	_
28	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7603
# text = The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	almost	almost	ADV	RB	_	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	integrity	integrity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	dimeric	dimeric	ADJ	JJ	Degree=Pos	_	_	_	_
16	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7604
# text = Document 0030011145 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011145	0030011145	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7605
# text = Constitutive expression of specific interferon isotypes in peripheral blood leukocytes from normal individuals and in promonocytic U937 cells.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
6	isotypes	isotype	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	U937	U937	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7606
# text = Constitutive expression of IFN-alpha5 and IFN-beta was detected in different lymphoid cells including peripheral blood mononuclear cells from normal individuals following amplification of IFN mRNA by reverse transcriptase-polymerase chain reaction and direct sequencing of the amplified product.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha5	alpha5	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
25	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	amplification	amplification	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
29	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
32	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
35	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
36	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
39	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	amplified	amplify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7607
# text = The activated form of the interferon-induced transcription factor complex ISGF3 was also detected in nuclear extracts from uninduced cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	ISGF3	ISGF3	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7608
# text = Culture supernatants from uninduced U937 cells were also found to activate an ISRE cloned upstream of the luciferase reporter gene, indicating the presence of endogenous IFN activity equivalent to approximately 0.3 to 0.5 IU/mL.
1	Culture	culture	ADJ	JJ	Degree=Pos	_	_	_	_
2	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
5	U937	U937	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	ISRE	Isre	ADJ	JJ	Degree=Pos	_	_	_	_
14	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	luciferase	luciferase	ADJ	JJ	Degree=Pos	_	_	_	_
19	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
27	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	approximately	approximately	ADV	RB	_	_	_	_	_
32	0.3	0.3	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
35	IU	IU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	mL	mL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7609
# text = This endogenous IFN was also shown to play a role in maintaining the basal level of expression of the major histocompatibility class I genes in lymphoid cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
3	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7610
# text = These results suggest that IFN-alpha5 and IFN-beta are produced at low levels in normal tissues and play an important role in the regulation of cell function and in the maintenance of homeostasis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	alpha5	alpha5	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
24	role	role	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	function	function	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	homeostasis	homeostasis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7611
# text = Document 0030011149 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011149	0030011149	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7612
# text = Constitutive activation of NF-kB in human thymocytes.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7613
# text = NF-kB is a eukaryotic transcription regulatory factor.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7614
# text = In T cells and T cell lines, NF-kB is bound to a cytoplasmic proteic inhibitor, the IkB.
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	T	t	NUM	CD	NumType=Card	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteic	proteic	ADJ	JJ	Degree=Pos	_	_	_	_
18	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IkB	Ikb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7615
# text = Treatment of T cells with mitogens (phorbol esters) or cytokines (TNF alpha) induces NF-kB nuclear translocation and the subsequent expression of NF-kB dependent T cell genes.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
31	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	NUM	CD	NumType=Card	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7616
# text = Here we examined the activation of NF-kB in human T cell thymic progenitors.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
14	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
15	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7617
# text = We report differences in (Ca2+)i requirement for NF-kB activation in thymocytes as compared to mature T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	requirement	requirement	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7618
# text = Furthermore, our results indicated that thymocytes have a constitutively active form of NF-kB, suggesting that they are activated in vivo.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	thymocytes	thymocytes	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	constitutively	constitutively	ADV	RB	_	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
12	form	form	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7619
# text = Document 0030011151 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011151	0030011151	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7620
# text = Requirements for induction of vitamin D-mediated gene regulation in normal human B lymphocytes.
1	Requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
6	D-	D-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7621
# text = Mature human lymphocytes are unique targets of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3) in that vitamin D receptors (VDR) are not constitutively expressed, and specific cellular activation signals are required for both the up-regulation of VDR and establishment of reactivity to the lipophilic ligand.
1	Mature	Mature	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
6	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-dihydroxyvitamin	-dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
11	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	2D3	2D3	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
23	D	d	NOUN	NN	Number=Sing	_	_	_	_
24	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	constitutively	constitutively	ADV	RB	_	_	_	_	_
31	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	both	both	CCONJ	CC	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	establishment	establishment	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
52	to	to	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	lipophilic	lipophilic	ADJ	JJ	Degree=Pos	_	_	_	_
55	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7622
# text = Treatment of B lymphocytes with the cytokine IL-4 (IL-4), in the absence of prior activation, induces a weak up-regulation of VDR expression but fails to generate vitamin D-responsive element (VDRE)-reactive nuclear protein complexes or to initiate the genomic transcription of 25-hydroxyvitamin D3 24-hydroxylase.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
27	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	VDR	Vdr	ADJ	JJ	Degree=Pos	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	fails	fail	NOUN	NNS	Number=Plur	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
37	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
38	D-	D-	PUNCT	:	_	_	_	_	SpaceAfter=No
39	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
40	element	element	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	VDRE	VDRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
45	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
46	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
47	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
48	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
49	or	or	CCONJ	CC	_	_	_	_	_
50	to	to	PART	TO	_	_	_	_	_
51	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
58	hydroxyvitamin	hydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
59	D3	D3	NUM	CD	NumType=Card	_	_	_	_
60	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
61	-hydroxylase	-hydroxylase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7623
# text = Stimulation of B lymphocytes by either ligation of CD40
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	either	either	DET	DT	_	_	_	_	_
7	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 7624
# text = Ag or cross-linking the Ig receptor is also insufficient to render B lymphocytes responsive to 1 alpha,25(OH)2D3.
1	Ag	ag	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	cross	cross	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
4	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	render	render	VERB	VB	VerbForm=Inf	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	alpha,25	alpha,25	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7625
# text = However, this apparent lack of response to the secosterol can be overcome by stimulation of B lymphocytes with a combination of these cellular activation signals, which are sufficient to lead to G1 cell cycle progression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
5	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	secosterol	secosterol	NOUN	NN	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	overcome	overcome	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	G1	G1	NUM	CD	NumType=Card	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
37	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7626
# text = In the presence of 1 alpha,25(OH)2D3, cellular activation associated with stimulation of such a progression appears to be sufficient for the up-regulation of VDR message and protein and necessary for the establishment of VDRE binding complexes and the induction of 24-hydroxylase message.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	such	such	DET	PDT	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
21	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	VDR	Vdr	ADJ	JJ	Degree=Pos	_	_	_	_
32	message	message	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	establishment	establishment	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	VDRE	Vdre	PROPN	NNP	Number=Sing	_	_	_	_
42	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
43	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
51	message	message	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7627
# text = Furthermore, biologic functions are modulated, in that the hormone inhibits proliferation in a subset of the activated B cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
4	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
12	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7628
# text = These observations suggest that reactivity to 1 alpha,25(OH)2D3 is tightly regulated in B lymphocytes, requiring specific signals for its initiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	tightly	tightly	ADV	RB	_	_	_	_	_
15	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	requiring	require	VERB	VBG	VerbForm=Ger	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7629
# text = Document 0030011153 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011153	0030011153	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7630
# text = Functional analysis of cis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	-linked	-link	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
11	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7631
# text = Two consensus sequences, called X and Y boxes, capable of binding nuclear proteins and regulating expression in B cells have been defined within the immediate upstream region of major histocompatibility complex (MHC) class II promoters.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
3	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	X	x	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Y	y	ADJ	JJ	Degree=Pos	_	_	_	_
9	boxes	box	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	SCONJ	IN	_	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
28	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
32	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
33	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	class	class	NOUN	NN	Number=Sing	_	_	_	_
38	II	ii	NUM	CD	NumType=Card	_	_	_	_
39	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7632
# text = Unlike other class II promoters, the HLA-DR alpha (DRA) promoter also contains one element identical to the "octamer" motif of immunoglobulin variable region promoters that is responsible for B cell-specific transcription.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	class	class	NOUN	NN	Number=Sing	_	_	_	_
4	II	ii	NUM	CD	NumType=Card	_	_	_	_
5	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	one	one	NUM	CD	NumType=Card	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
24	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	"	"	PUNCT	''	_	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
29	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
30	region	region	NOUN	NN	Number=Sing	_	_	_	_
31	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7633
# text = This "octamer" in the context of DRA appears capable of binding both the ubiquitous (OTF-1) and lymphoid-specific (OTF-2) "octamer" binding proteins, but at least one other distinct "octamer" complex was found.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
3	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	"	"	PUNCT	''	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	context	context	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
10	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	SCONJ	IN	_	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	OTF	OTF	ADP	IN	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	lymphoid	lymphoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
24	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	OTF	Otf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
31	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	"	"	PUNCT	''	_	_	_	_	_
33	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	at	at	ADV	RB	_	_	_	_	_
38	least	least	ADV	RBS	Degree=Sup	_	_	_	_
39	one	one	NUM	CD	NumType=Card	_	_	_	_
40	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
41	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
42	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
43	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	"	"	PUNCT	''	_	_	_	_	_
45	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7634
# text = In order to characterize the function of cis-acting elements, we have developed an in vitro system in which a DRA promoter construct is transcribed more efficiently in extracts from B cells than in extracts from class II-negative HeLa cells.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cis-acting	cis-act	ADJ	JJ	Degree=Pos	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
17	system	system	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	more	more	ADV	RBR	_	_	_	_	_
27	efficiently	efficiently	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	than	than	ADP	IN	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	class	class	NOUN	NN	Number=Sing	_	_	_	_
38	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
41	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7635
# text = 5' deletion constructs which lacked the Y box, but retained the "octamer" motif and TATA box were completely inactive, and internal deletion of the Y box reduced transcription by 95%.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	PUNCT	``	_	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Y	y	NOUN	NN	Number=Sing	_	_	_	_
9	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	retained	retain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
15	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	"	"	PUNCT	''	_	_	_	_	_
17	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
20	box	box	NOUN	NN	Number=Sing	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	completely	completely	ADV	RB	_	_	_	_	_
23	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
27	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	Y	y	PROPN	NNP	Number=Sing	_	_	_	_
31	box	box	NOUN	NN	Number=Sing	_	_	_	_
32	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7636
# text = Using supercoiled, but not linear templates, we observed differences in transcription efficiencies from templates lacking or disrupting the X consensus element that reflect effects of random replacement of X box sequences in transient expression assays.
1	Using	use	AUX	VBG	VerbForm=Ger	_	_	_	_
2	supercoiled	supercoiled	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	linear	linear	ADJ	JJ	Degree=Pos	_	_	_	_
7	templates	template	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	efficiencies	efficiency	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	templates	template	NOUN	NNS	Number=Plur	_	_	_	_
17	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	disrupting	disrupt	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	X	x	PROPN	NNP	Number=Sing	_	_	_	_
22	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	reflect	reflect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	random	random	NOUN	NN	Number=Sing	_	_	_	_
29	replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	X	x	NOUN	NN	Number=Sing	_	_	_	_
32	box	box	NOUN	NN	Number=Sing	_	_	_	_
33	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7637
# text = Demonstration of the complete dependence on the Y box in this system suggests that, despite its demonstrated importance in the DRA promoter, the DRA "octamer" does not utilize OTF-2 in a manner analogous to immunoglobulin promoters in B cells.
1	Demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
5	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Y	y	NOUN	NN	Number=Sing	_	_	_	_
9	box	box	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	_
13	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	despite	despite	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
27	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
28	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	"	"	PUNCT	''	_	_	_	_	_
30	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	utilize	utilize	VERB	VB	VerbForm=Inf	_	_	_	_
33	OTF	Otf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
39	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	immunoglobulin	immunoglobulin	VERB	VB	VerbForm=Inf	_	_	_	_
42	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7638
# text = Document 0030011155 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011155	0030011155	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7639
# text = Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
9	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	development	development	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-helix	-helix	NUM	CD	NumType=Card	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7640
# text = Id3 in committed T cell progenitors.
1	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	committed	committed	ADJ	JJ	Degree=Pos	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7641
# text = Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta and gamma delta cells in a fetal thymic organ culture (FTOC).
1	Enforced	Enforced	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Id3	Id3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
12	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
13	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
14	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-helix	-helix	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	bHLH	bHLH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	+)	+)	SYM	NFP	_	_	_	_	_
27	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
28	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	undergone	undergone	ADJ	JJ	Degree=Pos	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
42	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
43	development	development	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	transduced	transduced	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	into	into	ADP	IN	_	_	_	_	_
49	TCRalpha	TCRalpha	PROPN	NNP	Number=Sing	_	_	_	_
50	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
53	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
57	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
58	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
59	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
60	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
61	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
62	FTOC	FTOC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7642
# text = Here we document that overexpression of Id3, in progenitors that have initiated TCR gene rearrangements (pre-T cells), inhibits development into TCRalpha beta but not into TCRgamma delta T cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	document	document	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Id3	Id3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	TCR	Tcr	ADP	IN	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	pre-T	pre-t	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
23	development	development	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	TCRalpha	TCRalpha	PROPN	NNP	Number=Sing	_	_	_	_
26	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	TCRgamma	TCRgamma	PROPN	NNP	Number=Sing	_	_	_	_
31	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
32	T	T	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7643
# text = Furthermore, Id3 impedes expression of recombination activating genes and downregulates pre-Talpha mRNA.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
4	impedes	impede	NOUN	NNS	Number=Plur	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
8	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	downregulates	downregulate	NOUN	NNS	Number=Plur	_	_	_	_
12	pre-Talpha	pre-Talpha	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7644
# text = These observations suggest possible mechanisms by which Id3 overexpression can differentially affect development of pre-T cells into TCRalpha beta and gamma delta cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	which	which	DET	WDT	PronType=Int	_	_	_	_
8	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
9	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	differentially	differentially	ADV	RB	_	_	_	_	_
12	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	pre-T	pre-t	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	TCRalpha	TCRalpha	PROPN	NNP	Number=Sing	_	_	_	_
19	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
22	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7645
# text = We also observed that cell surface CD4(-)CD8(-)CD3(-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
10	CD8	CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	(-)	(-)	PUNCT	.	_	_	_	_	SpaceAfter=No
12	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	-)	-)	PUNCT	.	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	Id3	Id3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	pre-T	pre-t	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	FTOC	FTOC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7646
# text = These cells had properties of both natural killer (NK) and pre-T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
8	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	pre-T	pre-t	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7647
# text = These findings suggest that bHLH factors are required to control T cell development after the T/NK developmental checkpoint.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	bHLH	bhlh	DET	DT	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	T/	t/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
18	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
19	checkpoint	checkpoint	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7648
# text = Document 0030011156 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011156	0030011156	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7649
# text = Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells.
1	Physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
2	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7650
# text = The transcriptional regulatory elements of many inducible T-cell genes contain adjacent or overlapping binding sites for the Ets and NF-kappaB/NFAT families of transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	overlapping	overlapp	VERB	VBG	VerbForm=Ger	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
26	families	family	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7651
# text = Similar arrays of functionally important NF-kappaB/NFAT and Ets binding sites are present in the transcriptional enhancers of human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2), suggesting that this pattern of nuclear protein binding sites reflects an evolutionarily conserved mechanism for regulating inducible T-cell gene expression that has been co-opted during HIV evolution.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	arrays	array	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	functionally	functionally	ADV	RB	_	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	viruses	viruse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	types	type	NOUN	NNS	Number=Plur	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
45	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
46	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
47	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
48	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	evolutionarily	evolutionarily	ADV	RB	_	_	_	_	_
51	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
53	for	for	SCONJ	IN	_	_	_	_	_
54	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
55	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
56	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
58	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
59	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
60	that	that	PRON	WDT	PronType=Rel	_	_	_	_
61	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
62	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
63	co	co	X	AFX	_	_	_	_	SpaceAfter=No
64	-opted	-opt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
65	during	during	ADP	IN	_	_	_	_	_
66	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
67	evolution	evolution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7652
# text = Despite these findings, the molecular mechanisms by which Ets and NF-kappaB/NFAT proteins cooperatively regulate inducible T-cell gene expression remained unknown.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	findings	findings	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	which	which	DET	WDT	PronType=Int	_	_	_	_
10	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	cooperatively	cooperatively	ADV	RB	_	_	_	_	_
19	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7653
# text = In the studies described in this report, we demonstrated a physical interaction between multiple Ets and NF-kappaB/NFAT proteins both in vitro and in activated normal human T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
13	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	Ets	et	PROPN	NNPS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	both	both	CCONJ	CC	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7654
# text = This interaction is mediated by the Ets domain of Ets proteins and the C-terminal region of the Rel homology domains of NF-kappaB/NFAT proteins.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
21	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7655
# text = In addition, the Ets-NF-kappaB/NFAT interaction requires the presence of DNA binding sites for both proteins, as it is abolished by the DNA intercalating agents propidium iodide and ethidium bromide and enhanced by the presence of synthetic oligonucleotides containing binding sites for Ets and NF-kappaB proteins.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Ets-NF	Ets-NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	intercalating	intercalat	VERB	VBG	VerbForm=Ger	_	_	_	_
30	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
31	propidium	propidium	NOUN	NN	Number=Sing	_	_	_	_
32	iodide	iodide	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	ethidium	ethidium	NOUN	NN	Number=Sing	_	_	_	_
35	bromide	bromide	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
43	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
44	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
45	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
46	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	Ets	Ets	PROPN	NNP	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
53	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7656
# text = A dominant-negative mutant of NF-kappaB p50 that binds DNA but fails to interact with Ets proteins inhibits the synergistic activation of the HIV-1 and HIV-2 enhancers by NF-kappaB (p50 + p65) and Ets-1, suggesting that physical interaction between Ets and NF-kappaB proteins is required for the transcriptional activity of the HIV-1 and HIV-2 enhancers.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	fails	fail	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	Ets	ets	PROPN	NNP	Number=Sing	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	p50	p50	NUM	CD	NumType=Card	_	_	_	_
41	+	+	SYM	SYM	_	_	_	_	_
42	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
50	that	that	SCONJ	IN	_	_	_	_	_
51	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
52	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
53	between	between	ADP	IN	_	_	_	_	_
54	Ets	Ets	PROPN	NNP	Number=Sing	_	_	_	_
55	and	and	CCONJ	CC	_	_	_	_	_
56	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
59	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
60	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
61	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
62	for	for	ADP	IN	_	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
65	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	1	1	NUM	CD	NumType=Card	_	_	_	_
71	and	and	CCONJ	CC	_	_	_	_	_
72	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
74	2	2	NUM	CD	NumType=Card	_	_	_	_
75	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7657
# text = Taken together, these findings suggest that evolutionarily conserved physical interactions between Ets and NF-kappaB/NFAT proteins are important in regulating the inducible expression of T-cell genes and viruses.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	evolutionarily	evolutionarily	ADV	RB	_	_	_	_	_
9	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
11	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	SCONJ	IN	_	_	_	_	_
24	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7658
# text = These interactions represent a potential target for the development of novel immunosuppressive and antiviral therapies.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
3	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	target	target	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	development	development	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
15	therapies	therapy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7659
# text = Document 0030011158 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011158	0030011158	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7660
# text = Human CD3-CD16+ natural killer cells express the hGATA-3 T cell transcription factor and an unrearranged 2.3-kb TcR delta transcript.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	CD3-CD	Cd3-cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	_
5	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
6	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-3	-3	NUM	CD	NumType=Card	_	_	_	_
12	T	t	NUM	CD	NumType=Card	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
19	2.3	2.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
22	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	_
23	delta	delta	ADP	IN	Abbr=Yes	_	_	_	_
24	transcript	transcriep	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7661
# text = In this study we analyzed the T cell receptor(TcR) delta transcripts expressed by CD3-CD16+ cells and we investigated whether these cells expressed the hGATA-3 T cell transcription factor and the recombination-activating gene (RAG)-1.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
14	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	CD3-CD	Cd3-cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	whether	whether	SCONJ	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	hGATA	hGATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-3	-3	NUM	CD	NumType=Card	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7662
# text = Multiple TcR delta transcripts deriving from an unrearranged TcR delta gene were detected in both polyclonal and clonal CD3-CD16+ natural killer(NK) cell lines.
1	Multiple	multiple	PROPN	NNP	Number=Sing	_	_	_	_
2	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
3	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
4	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
5	deriving	derive	VERB	VBG	VerbForm=Ger	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
9	TcR	Tcr	PROPN	NNP	Number=Sing	_	_	_	_
10	delta	delof	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
19	CD3-CD	Cd3-cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
23	killer	killer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7663
# text = Two unrearranged TcR delta transcripts had a size similar to that of the functional TcR delta mRNA (2.3 and 1.3 kb) found in TcR gamma/delta+
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	unrearranged	unrearrang	ADJ	JJ	Degree=Pos	_	_	_	_
3	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	_
4	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	size	size	NOUN	NN	Number=Sing	_	_	_	_
9	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
16	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	2.3	2.3	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	1.3	1.3	NUM	CD	NumType=Card	_	_	_	_
22	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
27	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	delta	delta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 7664
# text = T lymphocytes.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7665
# text = Sequence analysis of nine different 2.3-kb cDNA clones obtained from NK-derived polyA+ RNA confirmed that they corresponded to an unrearranged TcR delta gene.
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nine	nine	NUM	CD	NumType=Card	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	2.3	2.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
9	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
10	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
11	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	polyA	polya	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
19	confirmed	confirm	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
22	corresponded	correspond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
26	TcR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
27	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7666
# text = These cDNA were 2343 bp long and their transcription initiation site was located 814 bp upstream from the J delta 1 segment.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	2343	2343	NUM	CD	NumType=Card	_	_	_	_
5	bp	bp	ADV	RB	_	_	_	_	_
6	long	long	ADV	RB	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	814	814	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	J	j	PROPN	NNP	Number=Sing	_	_	_	_
20	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	segment	segment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7667
# text = The sequence located upstream of the J delta 1 segment corresponded to the previously reported germ-line sequence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	J	j	PROPN	NNP	Number=Sing	_	_	_	_
8	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
11	corresponded	correspond	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	previously	previously	ADV	RB	_	_	_	_	_
15	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	germ	germ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7668
# text = The J delta 1 segment was correctly spliced to C delta; in addition the four C delta exons were found to be already assembled.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	J	j	PROPN	NNP	Number=Sing	_	_	_	_
3	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	correctly	correctly	ADV	RB	_	_	_	_	_
8	spliced	splice	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	delta	delta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	four	four	NUM	CD	NumType=Card	_	_	_	_
17	C	C	NOUN	NN	Number=Sing	_	_	_	_
18	delta	delta	PART	TO	Abbr=Yes	_	_	_	_
19	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	already	already	ADV	RB	_	_	_	_	_
25	assembled	assemble	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7669
# text = Two polyadenylation sites were present in the fourth C delta exon.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	fourth	fourth	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	_
10	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
11	exon	exon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7670
# text = However, only that located at the 3' end appeared to be utilized in the 2.3-kb cDNA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PART	POS	_	_	_	_	_
10	end	end	NOUN	NN	Number=Sing	_	_	_	_
11	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	2.3	2.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
20	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7671
# text = The expression of hGATA-3, a T cell-specific factor known to be involved in the regulation of the transcription of TcR delta locus, was analyzed by Northern blot, in cultured NK cell population and clones (but not in freshly derived cell populations).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hGATA	hGATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
26	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
27	locus	locus	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	Northern	northern	PROPN	NNP	Number=Sing	_	_	_	_
33	blot	blot	ADV	RB	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	population	population	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	but	but	CCONJ	CC	_	_	_	_	_
44	not	not	PART	RB	_	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	freshly	freshly	ADV	RB	_	_	_	_	_
47	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7672
# text = All NK clones and cell lines studied were found to express hGATA-3-specific mRNA, suggesting that hGATA-3 may be involved in the regulation of the unrearranged TcR delta gene expression in NK cells.
1	All	all	DET	DT	_	_	_	_	_
2	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
12	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	hGATA	hGATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
33	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	_
34	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7673
# text = Finally, no transcription of the RAG-1 gene could be detected in all NK cell lines or clones analyzed.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
21	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7674
# text = Document 0030011160 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011160	0030011160	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7675
# text = NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.
1	NF	Nf	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	CAML	caml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	interacting	interacting	VERB	VBG	VerbForm=Ger	_	_	_	_
11	member	member	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7676
# text = Activation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
20	event	event	NOUN	NN	Number=Sing	_	_	_	_
21	underlying	underly	ADJ	JJ	Degree=Pos	_	_	_	_
22	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
23	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7677
# text = The CAML (calcium-modulator and cyclophilin ligand) protein is a coinducer of NF-AT activation when overexpressed in Jurkat T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CAML	caml	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	coinducer	coinducer	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7678
# text = A member of the tumor necrosis factor receptor superfamily was isolated by virtue of its affinity for CAML.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	member	member	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	superfamily	superfamily	ADV	RB	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	virtue	virtue	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7679
# text = Cross-linking of this lymphocyte-specific protein, designated TACI (transmembrane activator and CAML-interactor), on the surface of transfected Jurkat cells with TACI-specific antibodies led to activation of the transcription factors NF-AT, AP-1, and NFkappaB.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	TACI	Taci	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CAML	caml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	interactor	interactor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	TACI	TACI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
34	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7680
# text = TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate.
1	TACI	Taci	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	specifically	specifically	ADV	RB	_	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
17	CAML	caml	NOUN	NN	Number=Sing	_	_	_	_
18	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	thus	thus	ADV	RB	_	_	_	_	_
21	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	CAML	CAML	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
26	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7681
# text = Document 0030011161 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011161	0030011161	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7682
# text = Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression.
1	Distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7683
# text = We have examined the effects of N-acetyl-L-cysteine (NAC), a well-characterized, thiol-containing antioxidant, on agonist-induced monocytic cell adhesion to endothelial cells (EC).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-L	-l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
24	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7684
# text = NAC inhibited interleukin-1 (IL-1 beta)-induced, but not basal, adhesion with 50% inhibition at approximately 20 mM.
1	NAC	NAC	X	LS	_	_	_	_	_
2	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	%	%	SYM	NN	Number=Sing	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	approximately	approximately	ADV	RB	_	_	_	_	_
26	20	20	NUM	CD	NumType=Card	_	_	_	_
27	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7685
# text = Monocytic cell adhesion to EC in response to tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS), alpha-thrombin, or phorbol 12-myristate 13-acetate (PMA) was similarly inhibited by NAC.
1	Monocytic	Monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LPS	Lp	INTJ	UH	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
26	-thrombin	-thrombin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
30	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
32	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
33	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	similarly	similarly	ADV	RB	_	_	_	_	_
41	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7686
# text = Unlike published studies with pyrrolidinedithiocarbamate, which specifically inhibited vascular cell adhesion molecule 1 (VCAM-1), NAC inhibited IL-1 beta-induced mRNA and cell surface expression of both E-selectin and VCAM-1.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	both	both	DET	DT	_	_	_	_	_
36	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7687
# text = NAC had no effect on the half-life of E-selectin or VCAM-1 mRNA.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	life	life	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7688
# text = Although NAC reduced nuclear factor-kappa B (NF-kappa B) activation in EC as measured by gel-shift assays using an oligonucleotide probe corresponding to the consensus NF-kappa B binding sites of the VCAM-1 gene (VCAM-NF-kappa B), the antioxidant had no appreciable effect when an oligomer corresponding to the consensus NF-kappa B binding site of the E-selectin gene (E-selectin-NF-kappa B) was used.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
3	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
24	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
28	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
29	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
38	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	VCAM	VCAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
51	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
56	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
57	no	no	DET	DT	_	_	_	_	_
58	appreciable	appreciable	ADJ	JJ	Degree=Pos	_	_	_	_
59	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
60	when	when	ADV	WRB	PronType=Int	_	_	_	_
61	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	_
63	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
64	to	to	ADP	IN	_	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
67	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
70	B	b	NOUN	NN	Number=Sing	_	_	_	_
71	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
72	site	site	NOUN	NN	Number=Sing	_	_	_	_
73	of	of	ADP	IN	_	_	_	_	_
74	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
75	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
77	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
78	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
79	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
80	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
82	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
84	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
85	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
86	)	)	PUNCT	-RRB-	_	_	_	_	_
87	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
88	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
89	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7689
# text = Because NF-kappa
1	Because	because	SCONJ	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 7690
# text = B has been reported to be redox sensitive, we studied the effects of NAC on the EC redox environment.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	redox	redox	ADV	RB	_	_	_	_	_
8	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
19	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
20	environment	environment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7691
# text = NAC caused an expected dramatic increase in the reduced glutathione (GSH) levels in EC.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	GSH	GSH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7692
# text = In vitro studies demonstrated that whereas the binding affinity of NF-kappa B to the VCAM-NF-kappa B oligomer peaked at a GSH-to-oxidized glutathione (GSSG) ratio of approximately 200 and decreased at higher ratios, the binding to the E-selectin-NF-kappa B oligomer appeared relatively unaffected even at ratios > 400, i.e., those achieved in EC treated with 40 mM NAC.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	whereas	whereas	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	VCAM	VCAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	_
24	peaked	peake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	approximately	approximately	ADV	RB	_	_	_	_	_
39	200	200	NUM	CD	NumType=Card	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	at	at	ADP	IN	_	_	_	_	_
43	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
44	ratios	ratio	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
55	B	b	PROPN	NNP	Number=Sing	_	_	_	_
56	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	_
57	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
58	relatively	relatively	ADV	RB	_	_	_	_	_
59	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
60	even	even	ADV	RB	_	_	_	_	_
61	at	at	ADP	IN	_	_	_	_	_
62	ratios	ratio	NOUN	NNS	Number=Plur	_	_	_	_
63	>	>	PUNCT	,	_	_	_	_	_
64	400	400	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	,	,	PUNCT	,	_	_	_	_	_
66	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
69	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
70	in	in	ADP	IN	_	_	_	_	_
71	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
72	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
73	with	with	ADP	IN	_	_	_	_	_
74	40	40	NUM	CD	NumType=Card	_	_	_	_
75	mM	mm	PROPN	NNP	Number=Sing	_	_	_	_
76	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7693
# text = These results suggest that NF-kappa B binding to its consensus sequences in the VCAM-1 and E-selectin gene exhibits marked differences in redox sensitivity, allowing for differential gene expression regulated by the same transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	exhibits	exhibit	NOUN	NNS	Number=Plur	_	_	_	_
24	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
28	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7694
# text = Our data also demonstrate that NAC increases the GSH-to-GSSG ratio within the EC suggesting one possible mechanism through which this antioxidant inhibits agonist-induced monocyte adhesion to EC.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
7	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	_
14	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
18	suggesting	suggest	NOUN	NN	Number=Sing	_	_	_	_
19	one	one	NUM	CD	NumType=Card	_	_	_	_
20	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
26	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7695
# text = Document 0030011166 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011166	0030011166	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7696
# text = Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.
1	Dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
5	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7697
# text = Human phagocytes recognize bacterial LPS (endotoxin) through membrane CD14 (mCD14), a proinflammatory LPS receptor.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
5	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7698
# text = This study tested the hypothesis that anti-LPS Abs neutralize endotoxin by blocking cellular uptake through mCD14.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	ADV	WRB	PronType=Rel	_	_	_	_
7	anti-LPS	anti-LPS	ADJ	JJ	Degree=Pos	_	_	_	_
8	Abs	Abs	PROPN	NNPS	Number=Plur	_	_	_	_
9	neutralize	neutralize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	endotoxin	endotoxin	ADV	RB	_	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
13	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	mCD	mCD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7699
# text = Ab-associated changes in the uptake and cellular distribution of FITC-LPS were assessed by flow cytometry and laser scanning confocal microscopy in human CD14-transfected Chinese hamster ovary fibroblasts (CHO-CD14 cells) and human peripheral blood monocytes.
1	Ab-	Ab-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	FITC	FITC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
18	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	laser	laser	NOUN	NN	Number=Sing	_	_	_	_
21	scanning	scan	VERB	VBG	VerbForm=Ger	_	_	_	_
22	confocal	confocal	ADJ	JJ	Degree=Pos	_	_	_	_
23	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
30	hamster	hamster	NOUN	NN	Number=Sing	_	_	_	_
31	ovary	ovary	ADJ	JJ	Degree=Pos	_	_	_	_
32	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	14	14	NUM	CD	NumType=Card	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
43	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
44	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7700
# text = LPS core- and O-side chain-specific mAbs inhibited mCD14-mediated LPS uptake by both cell types in the presence of serum.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	core	core	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	O-	O-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	side	side	NOUN	NN	Number=Sing	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	mCD14	mcd14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-mediated	-mediate	ADJ	JJ	Degree=Pos	_	_	_	_
14	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
15	uptake	uptake	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	types	type	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7701
# text = O-side chain-specific mAb concurrently enhanced complement-dependent LPS uptake by monocytes through complement receptor-1 (CR1) and uptake by CHO-CD14 cells involving another heat-labile serum factor(s) and cell-associated recognition molecule(s).
1	O	of	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	side	side	NOUN	NN	Number=Sing	_	_	_	_
4	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
8	concurrently	concurrently	ADV	RB	_	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	complement	complement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
14	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CR1	Cr1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	14	14	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
34	another	another	DET	DT	_	_	_	_	_
35	heat	heat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
38	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	s	s	X	AFX	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
48	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	s	s	X	AFX	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7702
# text = Core-specific mAb inhibited mCD14-mediated uptake of homologous and heterologous LPS, while producing less concurrent enhancement of non-mCD14-mediated LPS uptake.
1	Core-	Core-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
4	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	mCD14	mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
13	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
18	concurrent	concurrent	ADJ	JJ	Degree=Pos	_	_	_	_
19	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	non-mCD14	non-mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
23	LPS	Lp	NOUN	NN	Number=Sing	_	_	_	_
24	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7703
# text = The modulation by anti-LPS mAbs of mCD14-mediated LPS uptake was associated with inhibition of LPS-induced nuclear factor-kappaB (NF-kappaB) translocation and TNF-alpha secretion in CHO-CD14 cells and monocytes, respectively, while mAb enhancement of non-mCD14-mediated LPS uptake stimulated these activities.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	anti-LPS	anti-LPS	ADJ	JJ	Degree=Pos	_	_	_	_
5	mAbs	mAbs	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	mCD14	mCD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-mediated	-mediated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
10	uptake	uptake	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	CHO	cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	14	14	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	while	while	SCONJ	IN	_	_	_	_	_
46	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
47	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	non-mCD14	non-mCD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
51	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
52	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
53	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
55	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7704
# text = LPS-specific
1	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 7705
# text = Abs thus mediate anti-inflammatory and proinflammatory functions, respectively, by preventing target cell uptake of LPS through mCD14 and augmenting uptake through CR1 or other cell receptors.
1	Abs	Ab	ADV	RB	_	_	_	_	_
2	thus	thus	ADV	RB	_	_	_	_	_
3	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
13	target	target	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	mCD14	mCD14	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
22	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	CR1	Cr1	PROPN	NNP	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7706
# text = Document 0030011171 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011171	0030011171	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7707
# text = Increased IkappaB expression and diminished nuclear NF-kappaB in human mononuclear cells following hydrocortisone injection.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	hydrocortisone	hydrocortisone	ADJ	JJ	Degree=Pos	_	_	_	_
16	injection	injection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7708
# text = We have recently demonstrated that hydrocortisone and other glucocorticoids inhibit reactive oxygen species (ROS) generation by mononuclear (MNC) and polymorphonuclear leucocytes (PMNL).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	hydrocortisone	hydrocortisone	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
10	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
13	species	species	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ROS	ROS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	PMNL	PMNL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7709
# text = Since NF-kappaB/IkappaB system regulates the transcription of proinflammatory genes, including those responsible for ROS generation, we tested the hypothesis that hydrocortisone may stimulate IkappaB production thus inhibiting NF-kappaB translocation from the cytosol into the nucleus in MNC, in vivo.
1	Since	since	ADP	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	system	system	NOUN	NN	Number=Sing	_	_	_	_
8	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	ROS	Ros	NOUN	NN	Number=Sing	_	_	_	_
20	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	hydrocortisone	hydrocortisone	PRON	NN	Number=Sing	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
30	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	production	production	NOUN	NN	Number=Sing	_	_	_	_
32	thus	thus	ADV	RB	_	_	_	_	_
33	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
41	into	into	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7710
# text = One hundred milligram of hydrocortisone was injected intravenously into 4 normal subjects.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	hundred	hundred	NUM	CD	NumType=Card	_	_	_	_
3	milligram	milligram	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	hydrocortisone	hydrocortisone	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	injected	inject	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	intravenously	intravenously	ADV	RB	_	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7711
# text = Blood samples were obtained prior to the injection and at 1, 2, 4, 8 and 24 hr after the injection.
1	Blood	Blood	ADJ	JJ	Degree=Pos	_	_	_	_
2	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	injection	injection	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	8	8	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	_
20	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	injection	injection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7712
# text = Nuclear extracts and total cell lysates were prepared from MNC by standard techniques.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	standard	standard	ADJ	JJ	Degree=Pos	_	_	_	_
13	techniques	technique	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7713
# text = IkappaB
1	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 7714
# text = levels in MNC homogenates increased at 1 hr, peaked at 2-4 hr, started to decrease at 8 hr, and returned to baseline levels at 24 hr.
1	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
4	homogenates	homogenate	NOUN	NNS	Number=Plur	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	peaked	peake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	started	start	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	8	8	NUM	CD	NumType=Card	_	_	_	_
22	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	returned	return	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	24	24	NUM	CD	NumType=Card	_	_	_	_
31	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7715
# text = NF-kappaB in MNC nuclear extracts decreased at 1 hr, reached a nadir at 4 hr, gradually increased at 8 hr and returned back to baseline levels at 24 hr.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	nadir	nadir	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	gradually	gradually	ADV	RB	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	8	8	NUM	CD	NumType=Card	_	_	_	_
24	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	returned	return	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	back	back	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	24	24	NUM	CD	NumType=Card	_	_	_	_
33	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7716
# text = The total protein content of NF-kappaB subunit (P65) in MNC lysates also showed a decrease following hydrocortisone injection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	content	content	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	P65	P65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
15	lysates	lysates	PROPN	NNP	Number=Sing	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
20	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	hydrocortisone	hydrocortisone	ADJ	JJ	Degree=Pos	_	_	_	_
22	injection	injection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7717
# text = This decrease was observed at 2 hr, reached a nadir at 4 hr, and returned to baseline levels at 24 hr.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	nadir	nadir	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	returned	return	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	baseline	baseline	VERB	VB	VerbForm=Inf	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	24	24	NUM	CD	NumType=Card	_	_	_	_
23	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7718
# text = ROS generation inhibition paralleled NF-kappaB levels in the nucleus.
1	ROS	Ros	NOUN	NN	Number=Sing	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7719
# text = It was inhibited at 1 hr, reached a nadir at 2-4 hr, started to increase at 8 hr, and returned to basal levels at 24 hr.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	nadir	nadir	NOUN	NN	Number=Sing	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	started	start	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	8	8	NUM	CD	NumType=Card	_	_	_	_
22	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	returned	return	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	24	24	NUM	CD	NumType=Card	_	_	_	_
31	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7720
# text = Our data demonstrate that hydrocortisone induces IkappaB and suppresses NF-kappaB expression in MNC in parallel.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	hydrocortisone	hydrocortisone	PRON	NN	Number=Sing	_	_	_	_
6	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	MNC	MNC	PROPN	NNP	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7721
# text = IkappaB further reduces the translocation of NF-kappaB into the nucleus thus preventing the expression of proinflammatory genes.
1	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
13	thus	thus	ADV	RB	_	_	_	_	_
14	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7722
# text = Document 0030011179 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011179	0030011179	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7723
# text = Anaphylatoxins C5a and C3a induce nuclear factor kappaB activation in human peripheral blood monocytes.
1	Anaphylatoxins	Anaphylatoxins	PROPN	NNP	Number=Sing	_	_	_	_
2	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	C3	C3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7724
# text = The anaphylatoxins C5a and C3a are involved in the regulation of cytokine production.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	anaphylatoxins	anaphylatoxin	NOUN	NNS	Number=Plur	_	_	_	_
3	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	a	a	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	C3	C3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7725
# text = In this study the capability of C5a and C3a to induce transcription factor activation was examined.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	capability	capability	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7726
# text = C5a and C3a stimulation of human peripheral blood monocytes resulted in nuclear expression of a DNA binding activity with specificity to the kappaB sequence.
1	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	C3	C3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7727
# text = The p50 and p65 proteins, constituents of the prototypic nuclear factor kappaB, were identified as components of the DNA-protein complexes by anti-peptide antibodies in gel supershift assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	constituents	constituent	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	prototypic	prototypic	ADJ	JJ	Degree=Pos	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	components	component	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	anti-peptide	anti-peptide	ADJ	JJ	Degree=Pos	_	_	_	_
27	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
30	supershift	supershift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7728
# text = C5a induced kappaB binding activity was detected 15 min after agonist stimulation, peaked at 30-40 min, and remained detectable at 2 h.
1	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	15	15	NUM	CD	NumType=Card	_	_	_	_
10	min	min	NOUN	NNS	Number=Plur	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	peaked	peake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	40	40	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7729
# text = Binding to kappaB sequence was accompanied by an initial decrease and subsequent increase in the cytoplasmic IkappaBalpha levels, as detected by Western blotting using an anti-IkappaBalpha antibody.
1	Binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
10	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	as	as	SCONJ	IN	_	_	_	_	_
21	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
24	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	anti-IkappaBalpha	anti-IkappaBalpha	ADJ	JJ	Degree=Pos	_	_	_	_
28	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7730
# text = Pertussis toxin treatment markedly decreased kappaB binding activities induced by both C5a and C3a, whereas cholera toxin displayed no inhibitory effect.
1	Pertussis	Pertussis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	markedly	markedly	ADV	RB	_	_	_	_	_
5	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	C3a	C3a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
19	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
20	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7731
# text = Neither of the two toxins affected kappaB binding activity induced by TNFalpha in the same cells.
1	Neither	neither	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	toxins	toxin	NOUN	NNS	Number=Plur	_	_	_	_
6	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7732
# text = These results imply a potential role of the anaphylatoxins C5a and C3a in regulating leukocytes gene expression through G protein-coupled transcription factor activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	anaphylatoxins	anaphylatoxins	PROPN	NNPS	Number=Plur	_	_	_	_
10	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	C3	C3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	in	in	NOUN	NN	Number=Sing	_	_	_	_
16	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	G	G	PROPN	NNP	Number=Sing	_	_	_	_
22	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7733
# text = Document 0030011186 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011186	0030011186	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7734
# text = Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	heparin	heparin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	epidermal	epidermal	ADJ	JJ	Degree=Pos	_	_	_	_
13	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7735
# text = Correlation with an increased kappa B binding activity.
1	Correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7736
# text = Human peripheral blood monocytes responded to stimulation of platelet-activating factor (PAF) with up-regulation of the transcript for heparin-binding epidermal growth factor-like growth factor (HB-EGF), a potent mitogen for vascular smooth muscle cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	responded	respond	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	heparin-	heparin-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	epidermal	epidermal	ADJ	JJ	Degree=Pos	_	_	_	_
27	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
41	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
44	smooth	smooth	ADJ	JJ	Degree=Pos	_	_	_	_
45	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7737
# text = This function of PAF was observed at nanomolar concentrations of the ligand, starting at 30 min after stimulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	nanomolar	nanomolar	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	starting	start	VERB	VBG	VerbForm=Ger	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	30	30	NUM	CD	NumType=Card	_	_	_	_
17	min	min	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7738
# text = The PAF-induced up-regulation of HB-EGF mRNA was accompanied by an increase in kappa B binding activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7739
# text = These functions of PAF appeared to be mediated through the cell surface PAF receptors, as two PAF receptor antagonists, WEB 2086 and L-659,989, blocked both the up-regulation of HB-EGF mRNA and kappa B binding activity induced by PAF.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
5	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
13	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	WEB	Web	PROPN	NNP	Number=Sing	_	_	_	_
23	2086	2086	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	L-659,989	L-659,989	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	both	both	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
37	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7740
# text = The antagonists, however, had no effect on phorbol ester-induced up-regulation of HB-EGF mRNA and kappa B binding activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
21	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7741
# text = Pretreatment of monocytes with pertussis toxin inhibited these functions of PAF, whereas cholera toxin had no inhibitory effect.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	pertussis	pertussis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
15	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
16	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	no	no	DET	DT	_	_	_	_	_
18	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7742
# text = Pyrrolidine dithiocarbamate, an inhibitor for NF-kappa B activation, markedly reduced PAF-stimulated kappa B binding activity as well as up-regulation of HB-EGF mRNA.
1	Pyrrolidine	Pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
2	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	markedly	markedly	ADV	RB	_	_	_	_	_
14	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
32	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7743
# text = These results suggest a potential role of PAF in HB-EGF expression and provide evidence that this stimulation may occur through increased kappa B binding activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	HB	HB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	EGF	EGF	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7744
# text = Document 0030011190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011190	0030011190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7745
# text = Transcriptional down-regulation of c-myc expression by protein synthesis-dependent and -independent pathways in a human T lymphoblastic tumor cell line.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7746
# text = We show that in the human T lymphoblastic tumor cell line Molt4 c-myc mRNA and protein expression is down-regulated after exposure to dimethyl sulfoxide, to phorbol myristate acetate, or to the calcium ionophore A23187, which raises the intracellular calcium concentration.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	Molt4	molt4	NOUN	NN	Number=Sing	_	_	_	_
13	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	after	after	ADP	IN	_	_	_	_	_
24	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	dimethyl	dimethyl	VERB	VB	VerbForm=Inf	_	_	_	_
27	sulfoxide	sulfoxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
31	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
32	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
38	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
39	A23187	A23187	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	which	which	PRON	WDT	PronType=Rel	_	_	_	_
42	raises	raise	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
45	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
46	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7747
# text = A block to RNA elongation is largely responsible for decreased c-myc transcription.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	block	block	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
5	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	largely	largely	ADV	RB	_	_	_	_	_
8	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7748
# text = Although negative regulation by dimethyl sulfoxide takes place even when protein synthesis is inhibited by cycloheximide, the phorbol myristate acetate effect is blocked to some extent only by cycloheximide.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	dimethyl	dimethyl	ADJ	JJ	Degree=Pos	_	_	_	_
6	sulfoxide	sulfoxide	NOUN	NN	Number=Sing	_	_	_	_
7	takes	take	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	place	place	NOUN	NN	Number=Sing	_	_	_	_
9	even	even	ADV	RB	_	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
12	synthesis	synthesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	some	some	DET	DT	_	_	_	_	_
27	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7749
# text = The calcium ionophore-induced c-myc suppression, however, strictly requires de novo protein synthesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
3	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
8	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	strictly	strictly	ADV	RB	_	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	de	de	X	FW	Foreign=Yes	_	_	_	_
15	novo	novo	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7750
# text = Therefore, two different negative regulatory pathways are involved in c-myc regulation: one which is independent and one which depends on de novo protein synthesis.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	de	de	X	FW	Foreign=Yes	_	_	_	_
25	novo	novo	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7751
# text = The latter one appears to be mediated by a rapidly calcium-dependent induced gene product.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
3	one	one	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7752
# text = Document 0030011192 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011192	0030011192	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7753
# text = Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Runt	Runt	PROPN	NNP	Number=Sing	_	_	_	_
5	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
16	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7754
# text = The PEBP2 alpha
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7755
# text = A and PEBP2 alpha B genes encode the DNA-binding subunit of a murine transcription factor, PEBP2, which is implicated as a T-cell-specific transcriptional regulator.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	encode	encode	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7756
# text = These two related genes share the evolutionarily conserved region encoding the Runt domain.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	evolutionarily	evolutionarily	ADV	RB	_	_	_	_	_
8	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Runt	Runt	PROPN	NNP	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7757
# text = PEBP2 alpha
1	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7758
# text = B is the murine counterpart of human AML1, which is located at the breakpoints of the 8;21 and 3;21 chromosome translocations associated with acute myeloid leukemia.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
5	counterpart	counterpart	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	breakpoints	breakpoint	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	8;21	8;21	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	SpaceAfter=No
22	21	21	NUM	CD	NumType=Card	_	_	_	_
23	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
24	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
25	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
28	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
29	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7759
# text = Northern (RNA) blots of various adult mouse tissues revealed that the levels of expression of both genes were most prominent in the thymus.
1	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
8	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7760
# text = Furthermore, transcripts of PEBP2 alpha
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7761
# text = A and mouse AML1/PEBP2 alpha
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7762
# text = B were detected in T lymphocytes in the thymuses from day 16 embryos and newborns, as well as 4-week-old adult mice, by in situ hybridization.
1	B	benefit	NOUN	NN	Number=Sing	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	thymuses	thymuse	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	day	day	NOUN	NN	Number=Sing	_	_	_	_
12	16	16	NUM	CD	NumType=Card	_	_	_	_
13	embryos	embryo	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	newborns	newborn	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	ADV	RB	_	_	_	_	_
18	well	well	ADV	RB	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	week	week	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	old	old	ADJ	JJ	Degree=Pos	_	_	_	_
25	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
31	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7763
# text = The expression of the genes persisted in peripheral lymph nodes of adult mice.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	persisted	persist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
10	nodes	node	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
13	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7764
# text = The transcripts were detected in all the CD4- CD8-, CD4+ CD8+, CD4+ CD8-, and CD4- CD8+ cell populations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	all	all	DET	PDT	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	CD8-,	Cd8-,	NOUN	NN	Number=Sing	_	_	_	_
11	CD4+	Cd4+	NOUN	NN	Number=Sing	_	_	_	_
12	CD8+	Cd8+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CD4+	CD4+	CCONJ	CC	_	_	_	_	_
15	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-,	-,	PUNCT	.	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	_
20	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7765
# text = The results indicated that both genes are expressed in T cells throughout their development, supporting the notion that PEBP2 is a T-cell-specific transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	throughout	throughout	ADP	IN	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7766
# text = Transcripts of mouse AML1/PEBP2 alpha B were also detected in day 12 fetal hematopoietic liver and in the bone marrow cells of newborn mice.
1	Transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	AML1	AML1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	day	day	NOUN	NN	Number=Sing	_	_	_	_
14	12	12	NUM	CD	NumType=Card	_	_	_	_
15	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
16	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
17	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
22	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	newborn	newborn	ADJ	JJ	Degree=Pos	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7767
# text = The implication of mouse AML1/PEBP2 alpha B expression in hematopoietic cells other than those of T-cell lineage is discussed in relation to myeloid leukemogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	implication	implication	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
5	AML1	AML1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	than	than	ADP	IN	_	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	myeloid	myeloid	VERB	VB	VerbForm=Inf	_	_	_	_
27	leukemogenesis	leukemogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7768
# text = Document 0030011198 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011198	0030011198	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7769
# text = Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
6	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	E-	E-	X	GW	_	_	_	_	SpaceAfter=No
12	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
19	A	a	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7770
# text = Nuclear factor of activated T cells (NFAT) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A (CsA).
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	originally	originally	ADV	RB	_	_	_	_	_
12	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	athat	athat	PRON	WDT	PronType=Rel	_	_	_	_
22	supported	support	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
36	A	A	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7771
# text = As we observed that activated endothelial cells also expressed NFAT, we tested the antiinflammatory properties of CsA in endothelial cells.
1	As	as	SCONJ	IN	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	PRON	WDT	PronType=Dem	_	_	_	_
5	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7772
# text = Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor (GM-CSF) gene regulatory elements that use NFAT by 60%.
1	Significantly	significantly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
4	completely	completely	ADV	RB	_	_	_	_	_
5	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	gene	gene	PRON	NN	Number=Sing	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	NFAT	NFAT	ADV	RB	_	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	60%	60%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7773
# text = CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated endothelial cells.
1	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
2	similarly	similarly	ADV	RB	_	_	_	_	_
3	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	up	up	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7774
# text = CsA also suppressed E-selectin, but not vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT.
1	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	even	even	ADV	RB	_	_	_	_	_
26	though	though	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	rather	rather	ADV	RB	_	_	_	_	_
39	than	than	ADP	IN	_	_	_	_	_
40	NFAT	NFAT	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7775
# text = Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA, and this was reflected by a 29% decrease in neutrophil adhesion.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	reflected	reflect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	29	29	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	%	%	SYM	NN	Number=Sing	_	_	_	_
41	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	neutrophil	neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
44	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7776
# text = The effects of CsA on endothelial cells were also detected at the chromatin structure level, as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CsA	csa	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
14	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	DNasel	DNasel	PROPN	NNP	Number=Sing	_	_	_	_
19	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7777
# text = This represents the first report of NFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NFAT	Nfat	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	agent	agent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7778
# text = Document 0030011203 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011203	0030011203	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7779
# text = Cross-linking of CD44 on rheumatoid synovial cells up-regulates VCAM-1. CD44 is a ubiquitous molecule also known as hyaluronic acid or homing receptor.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CD44	CD44	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	up	up	X	GW	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n
17	CD44	Cd44	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
21	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	hyaluronic	hyaluronic	ADJ	JJ	Degree=Pos	_	_	_	_
26	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	homing	home	VERB	VBG	VerbForm=Ger	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7780
# text = However, the cellular functions and its role in inflammation, for example, rheumatoid synovitis, are currently unknown.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
8	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	synovitis	synovitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	currently	currently	ADV	RB	_	_	_	_	_
21	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7781
# text = In this study, we propose a novel function for CD44.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	CD44	CD44	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7782
# text = Using synovial cells from rheumatoid arthritis (RA) patients, we demonstrated that CD44 cross-linking and binding to hyaluronan augmented VCAM-1 expression and subsequently VCAM-1-mediated cell adhesion.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	rheumatoid	rheumatoid	NOUN	NN	Number=Sing	_	_	_	_
6	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	CD44	Cd44	PROPN	NNP	Number=Sing	_	_	_	_
16	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	hyaluronan	hyaluronan	VERB	VB	VerbForm=Inf	_	_	_	_
22	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	subsequently	subsequently	ADV	RB	_	_	_	_	_
29	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7783
# text = Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan, especially when fragmented, also up-regulated VCAM-1; 4) CD44 activated the transcription factor AP-1; and 5) the integrin-dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking.
1	Briefly	briefly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	1	1	X	LS	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	highly	highly	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	CD44	Cd44	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	CD44	CD44	PROPN	NNP	Number=Sing	_	_	_	_
21	markedly	markedly	ADV	RB	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	transiently	transiently	ADV	RB	_	_	_	_	_
24	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
31	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	much	much	ADV	RB	_	_	_	_	_
35	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
36	than	than	SCONJ	IN	_	_	_	_	_
37	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	;	;	PUNCT	,	_	_	_	_	_
47	3	3	X	LS	_	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	hyaluronan	hyaluronan	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	especially	especially	ADV	RB	_	_	_	_	_
52	when	when	ADV	WRB	PronType=Int	_	_	_	_
53	fragmented	fragment	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	also	also	ADV	RB	_	_	_	_	_
56	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	;	;	PUNCT	,	_	_	_	_	_
63	4	4	X	LS	_	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	CD44	CD44	PROPN	NNP	Number=Sing	_	_	_	_
66	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
69	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
70	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
71	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
72	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
73	;	;	PUNCT	,	_	_	_	_	_
74	and	and	CCONJ	CC	_	_	_	_	_
75	5	5	X	LS	_	_	_	_	SpaceAfter=No
76	)	)	PUNCT	-RRB-	_	_	_	_	_
77	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
78	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
79	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
80	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
81	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
82	function	function	NOUN	NN	Number=Sing	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
85	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
86	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
87	to	to	ADP	IN	_	_	_	_	_
88	T	t	PROPN	NNP	Number=Sing	_	_	_	_
89	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
90	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
91	also	also	ADV	RB	_	_	_	_	_
92	amplified	amplify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
93	by	by	ADP	IN	_	_	_	_	_
94	CD44	CD44	NUM	CD	NumType=Card	_	_	_	_
95	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
96	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
97	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7784
# text = These results indicate that the adhesion of RA synovial cells to matrices such as hyaluronic acid through CD44 could up-regulate VCAM-1 expression and VCAM-1-mediated adhesion to T cells, which might in turn cause activation of T cells and synovial cells in RA synovitis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
9	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	matrices	matrice	NOUN	NNS	Number=Plur	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	hyaluronic	hyaluronic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	CD44	CD44	PROPN	NNP	Number=Sing	_	_	_	_
19	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
20	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
23	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
40	in	in	ADV	RB	_	_	_	_	_
41	turn	turn	VERB	VB	VerbForm=Inf	_	_	_	_
42	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
52	synovitis	synovitis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7785
# text = We therefore propose that such cross-talking among distinct adhesion molecules may be involved in the pathogenesis of inflammation, including RA synovitis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-talking	-talk	VERB	VBG	VerbForm=Ger	_	_	_	_
8	among	among	ADP	IN	_	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
11	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	RA	RA	ADJ	JJ	Degree=Pos	_	_	_	_
23	synovitis	synovitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7786
# text = Document 0030011207 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011207	0030011207	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7787
# text = Suppression of a cellular differentiation program by phorbol esters coincides with inhibition of binding of a cell-specific transcription factor (NF-E2) to an enhancer element required for expression of an erythroid-specific gene.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	program	program	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
9	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
10	coincides	coincide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	SCONJ	IN	_	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	_
31	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7788
# text = Induction by hemin increases, while induction with 12-O-tetradecanoylphorbol-13-acetate (TPA) represses, erythroid-specific gene expression in the human cell line K562.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
4	increases	increase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	while	while	SCONJ	IN	_	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	12-O-	12-o-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	represses	represse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	_
28	K562	k562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7789
# text = We analyzed the effects of hemin or TPA induction on the binding and activity of transcription factors at a regulatory element found within the transcriptional regulatory sequences of many erythroid-specific genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
30	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7790
# text = TPA induction increases the binding of ubiquitous AP-1 factors to this element.
1	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7791
# text = TPA induction inhibits the binding of the lineage limited transcription factor NF-E2 to this transcriptional control element.
1	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
9	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7792
# text = Hemin induction of K562 cells does not facilitate the binding of NF-E2 to its recognition site.
1	Hemin	Hemin	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	K562	K562	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7793
# text = Hemin induction appears to nonspecifically increase the expression of transiently transfected genes in K562 cells.
1	Hemin	Hemin	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	nonspecifically	nonspecifically	ADV	RB	_	_	_	_	_
6	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transiently	transiently	ADV	RB	_	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	K562	K562	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7794
# text = Beyond this nonspecific increase in gene expression, hemin induction acts to increase the activity of the lineage limited transcription factor NF-E2.
1	Beyond	beyond	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
19	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7795
# text = The divergent effects of hemin and TPA on gene expression in K562 cells are mediated, in part, by their contrasting effects on the transcription factor NF-E2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	hemin	hemin	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	K562	K562	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	contrasting	contrast	NOUN	NN	Number=Sing	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7796
# text = Document 0030011213 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011213	0030011213	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7797
# text = Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Hox	Hox	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	hLH	hLh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	aberrantly	aberrantly	ADV	RB	_	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
18	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	9q33	9q33	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	34.1	34.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7798
# text = We describe the isolation of human LH-2, a putative transcription factor containing two cysteine-rich regions (LIM domains) and a homeobox
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	LH	Lh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
20	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LIM	Lim	NOUN	NN	Number=Sing	_	_	_	_
23	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	homeobox	homeobox	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7799
# text = (Hox) DNA-binding domain.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Hox	Hox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7800
# text = High levels of hLH-2 expression were observed in all cases of chronic myelogenous leukaemia (CML) tested, regardless of disease status.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hLH	hLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	CML	CML	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	tested	tested	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	regardless	regardless	ADV	RB	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
25	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7801
# text = hLH-2 was mapped to chromosome 9Q33-34.1, in the same region as the reciprocal translocation that creates the BCR-ABL chimera of the Philadelphia chromosome (Ph'), the hallmark of CML; hLH-2 was retained on the derivative 9 chromosome and is therefore centromeric of c-ABL.
1	hLH	hLh	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	chromosome	chromosome	VERB	VB	VerbForm=Inf	_	_	_	_
8	9Q33	9Q33	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	34.1	34.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	reciprocal	reciprocal	ADJ	JJ	Degree=Pos	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	creates	create	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	BCR	Bcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	ABL	Abl	NOUN	NN	Number=Sing	_	_	_	_
26	chimera	chimera	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Philadelphia	Philadelphia	PROPN	NNP	Number=Sing	_	_	_	_
30	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Ph	ph	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	hallmark	hallmark	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	CML	cml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	;	;	PUNCT	,	_	_	_	_	_
41	hLH	hLh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
46	on	on	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
49	9	9	NUM	CD	NumType=Card	_	_	_	_
50	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	therefore	therefore	ADV	RB	_	_	_	_	_
54	centromeric	centromeric	ADJ	JJ	Degree=Pos	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
57	ABL	ABL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7802
# text = The proximity of hLH-2 to the breakpoint on chromosome 9 raises the possibility of cis-activation by the t(9;22)(q34;q11) translocation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proximity	proximity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hLH	hLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	breakpoint	breakpoint	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	chromosome	chromosome	ADJ	JJ	Degree=Pos	_	_	_	_
12	9	9	NUM	CD	NumType=Card	_	_	_	_
13	raises	rais	NOUN	NNS	Number=Plur	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
18	-activation	-activation	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	t(	t(	SYM	NFP	_	_	_	_	SpaceAfter=No
22	9;22	9;22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	q34;q11	q34;q11	X	LS	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7803
# text = In addition to finding hLH-2 expression in all cases of CML, expression was observed in lymphoid malignancies and myeloid cell lines, but not in primary cases of acute myelogenous leukaemia.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	SCONJ	IN	_	_	_	_	_
4	finding	find	VERB	VBG	VerbForm=Ger	_	_	_	_
5	hLH	hLh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	all	all	DET	DT	_	_	_	_	_
11	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CML	CML	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	myeloid	myeloid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	not	not	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
30	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
33	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
34	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7804
# text = The role of hLH-2 in the development or progression of leukaemia is not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hLH	hLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	development	development	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7805
# text = However, hLH-2 may prove useful as a marker of CML for monitoring residual disease.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	hLH	hLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
8	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CML	cml	PROPN	NNP	Number=Sing	_	_	_	_
14	for	for	SCONJ	IN	_	_	_	_	_
15	monitoring	monitor	VERB	VBG	VerbForm=Ger	_	_	_	_
16	residual	residual	ADJ	JJ	Degree=Pos	_	_	_	_
17	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7806
# text = Document 0030011215 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011215	0030011215	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7807
# text = Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	lowered	lowered	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7808
# text = Transcription factor NF kappa B (nuclear factor kappa B) is induced in T lymphocytes from young individuals following activation with a variety of stimuli including anti-CD3, phorbol myristate acetate (PMA), and tumor necrosis factor-alpha (TNF-alpha).
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
19	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
20	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
27	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
28	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
31	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
32	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
39	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7809
# text = In contrast, activated T lymphocytes from older individuals show a significant reduction in the induction of NF kappa B in response to the same stimuli.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	older	older	ADJ	JJR	Degree=Cmp	_	_	_	_
9	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
10	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
26	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7810
# text = The age-related decline in induction of NF kappa B could not be attributed to alteration in the composition of subunits, p50 and p65 were found to be the predominant subunits of induced NF kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
5	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	p50	p50	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p65	p65	NUM	CD	NumType=Card	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
33	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 7811
# text = B in T cells from young as well as elderly donors.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
11	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7812
# text = Furthermore, similar levels of NF kappa B were found in the cytosols of unactivated T cells from both young and elderly donors suggesting that precursor levels of NF kappa B remain unaltered during aging.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cytosols	cytosol	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
23	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	unaltered	unaltered	ADJ	JJ	Degree=Pos	_	_	_	_
34	during	during	ADP	IN	_	_	_	_	_
35	aging	aging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7813
# text = These results suggest that an age-associated decline in the induction of NF kappa B in activated T cells from elderly individuals may be attributable to altered regulation of the inhibitor, I kappa B, and may play an important role in immune dysregulation accompanying aging.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	B	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
23	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
43	role	role	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
46	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
47	accompanying	accompany	VERB	VBG	VerbForm=Ger	_	_	_	_
48	aging	ag	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7814
# text = Document 0030011219 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011219	0030011219	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7815
# text = Expression of Ah receptor (TCDD receptor) during human monocytic differentiation.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TCDD	tCDd	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7816
# text = We have previously found a high expression of human
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 7817
# text = Ah receptor (TCDD receptor) mRNA in peripheral blood cells of individuals.
1	Ah	ah	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	TCDD	tCDd	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7818
# text = In this paper, the expression of this gene in blood cells was first investigated in fractions of nucleated cells, revealing predominant expression of the Ah receptor gene in the monocyte fraction.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	first	first	ADV	RB	_	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	nucleated	nucleate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	revealing	reveal	VERB	VBG	VerbForm=Ger	_	_	_	_
23	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
33	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7819
# text = Then the expression levels of AhR mRNA in various hematopoietic cell lines were examined together with those of Arnt and P450IA1.
1	Then	then	ADV	RB	PronType=Dem	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	together	together	ADV	RB	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Arnt	Arnt	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	P450IA1	P450ia1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7820
# text = AhR was expressed at high levels in monocytoid U937, THP1, and HEL/S cells, and at moderate levels in promyelocytic HL60 cells and erythroblastic HEL cells.
1	AhR	Ahr	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	THP1	THP1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	HEL/	HEL/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
15	S	s	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	erythroblastic	erythroblastic	ADJ	JJ	Degree=Pos	_	_	_	_
28	HEL	Hel	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7821
# text = However, it was not detected in lymphoid cells MOLT4 (T cell) and BALL1 (B cell), nor in K562 erythroblasts.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	MOLT4	Molt4	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	T	t	NUM	CD	NumType=Card	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	BALL1	Ball1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	nor	nor	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	K562	K562	NUM	CD	NumType=Card	_	_	_	_
25	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7822
# text = Furthermore, a specific induction of AhR during monocytic differentiation was investigated in HL60 and HEL cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	HL60	HL60	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	HEL	Hel	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7823
# text = HL60 cells were induced to differentiate toward monocytes-macrophages by incubation with phorbol ester, showing a 5- to 2-fold increase of AhR mRNA.
1	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
7	toward	toward	ADP	IN	_	_	_	_	_
8	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
28	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7824
# text = The incubation with transforming growth factor beta 1 and 1 alpha,25-dihydroxyvitamin D3 resulted in a 5- to 7-fold increase of AhR mRNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	SCONJ	IN	_	_	_	_	_
4	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-dihydroxyvitamin	-dihydroxyvitamin	ADJ	JJ	Degree=Pos	_	_	_	_
13	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
14	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
26	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7825
# text = The HEL cells also exhibited a similar elevation of AhR mRNA level, when they had differentiated toward monocyte-macrophage cells by these combined inducers, but little change in the mRNA level was observed when the cells were induced to differentiate into other cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HEL	Hel	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
8	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
16	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	toward	toward	ADP	IN	_	_	_	_	_
19	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
29	change	change	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
33	level	level	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	when	when	ADV	WRB	PronType=Int	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
43	into	into	ADP	IN	_	_	_	_	_
44	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7826
# text = Treatment of the differentiated HL60 cells with 3-methylcholanthrene, a ligand of AhR, induced the expression of the P450IA1 gene.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	methylcholanthrene	methylcholanthrene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	P450IA1	P450ia1	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7827
# text = These results indicated that expression of
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_

# sent_id = 7828
# text = AhR mRNA was significantly induced during monocytic differentiation and that the differentiated cells were responsive to xenobiotics.
1	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	differentiated	differentiated	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	xenobiotics	xenobiotic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7829
# text = Our results suggest that AhR may play an important role in the function of monocytes and also in the eventual activation of environmental carcinogens.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	AhR	AhR	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	eventual	eventual	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	environmental	environmental	ADJ	JJ	Degree=Pos	_	_	_	_
24	carcinogens	carcinogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7830
# text = Document 0030011228 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011228	0030011228	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7831
# text = Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	8	8	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
13	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7832
# text = IL-8, a potent chemotactic factor for neutrophil granulocytes and lymphocytes, is a proinflammatory cytokine secreted by a variety of cell types, including T cells.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
7	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	neutrophil	neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
11	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7833
# text = Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	delivers	deliver	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
30	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7834
# text = Anti-CD28-stimulated
1	Anti-CD28-stimulated	Anti-CD28-stimulated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 7835
# text = T cells produced significant amounts of IL-8; additionally, costimulation with anti-CD3 and anti-CD28
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 7836
# text = Abs resulted in a synergistic induction of IL-8 secretion.
1	Abs	Abs	PROPN	NNP	Number=Sing	_	_	_	_
2	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7837
# text = Sequence homology, single nucleotide mutations, and anti-CD28
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	homology	homology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
5	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 7838
# text = Ab stimulation studies established that the NF-kappa B-like sequence in the promoter of the IL-8 gene functioned as a CD28 response element.
1	Ab	Ab	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	established	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	8	8	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	functioned	functioned	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7839
# text = Furthermore, cyclosporin A, but not rapamycin, blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti-CD28 costimulation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
4	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	rapamycin	rapamycin	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	8	8	NUM	CD	NumType=Card	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
24	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7840
# text = The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8, such as psoriasis and rheumatoid arthritis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	8	8	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
22	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
23	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
31	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	_
32	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	psoriasis	psoriasis	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
46	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7841
# text = Document 0030011230 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011230	0030011230	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7842
# text = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome.
1	Genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
2	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
3	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
4	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
8	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
9	II	ii	NUM	CD	NumType=Card	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	dispersed	disperse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7843
# text = General transcription factors are required for accurate initiation of transcription by RNA polymerase II.
1	General	General	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	accurate	accurate	ADJ	JJ	Degree=Pos	_	_	_	_
8	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
13	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7844
# text = Human cDNAs encoding subunits of these factors have been cloned and sequenced.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
3	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
4	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	sequenced	sequence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7845
# text = Using fluorescence in situ hybridization (FISH), we show here that the genes encoding the TATA-box binding protein (TBP), TFIIB, TFIIE alpha, TFIIE beta, RAP30, RAP74 and the 62 kDa subunit, of TFIIH are located at the human chromosomal bands 6q26-27, 1p21-22, 3q21-24, 8p12, 13q14, 19p13.3 and 11p14-15.1, respectively.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
5	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	FISH	Fish	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	here	here	ADV	RB	PronType=Dem	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	box	box	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TBP	TBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	TFIIB	TFIIB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	TFIIE	TFIIE	PROPN	NNP	Number=Sing	_	_	_	_
30	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	TFIIE	TFIIE	PROPN	NNP	Number=Sing	_	_	_	_
33	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	RAP30	RAP30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	RAP74	RAP74	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	62	62	NUM	CD	NumType=Card	_	_	_	_
41	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
42	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	TFIIH	TFIIh	DET	DT	_	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	at	at	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
51	chromosomal	chromosomal	NOUN	NN	Number=Sing	_	_	_	_
52	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
53	6q26	6q26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-27	-27	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	1p21-22	1p21-22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	3q21-24	3q21-24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	8p12	8p12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	13q14	13q14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	19p13.3	19p13.3	NUM	CD	NumType=Card	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	11p14	11p14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
68	15.1	15.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7846
# text = This dispersed localization of a group of functionally related gene provides insights into the molecular mechanism of human genome evolution and their possible involvement in human diseases.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	dispersed	dispersed	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	group	group	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	functionally	functionally	ADV	RB	_	_	_	_	_
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
20	evolution	evolution	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
24	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7847
# text = Document 0030011239 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011239	0030011239	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7848
# text = Interferon-gamma and the sexual dimorphism of autoimmunity.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	sexual	sexual	ADJ	JJ	Degree=Pos	_	_	_	_
7	dimorphism	dimorphism	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7849
# text = The sexual difference in the incidence of autoimmune diseases has remained an enigma for many years.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sexual	sexual	ADJ	JJ	Degree=Pos	_	_	_	_
3	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	incidence	incidence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
9	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	remained	remain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	enigma	enigma	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
16	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7850
# text = In the examination of the induction of autoimmunity in transgenic mice, evidence has been obtained further implicating the lymphokine interferon-gamma in the etiology of autoimmunity.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	examination	examination	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	further	further	SCONJ	IN	_	_	_	_	_
18	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
21	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7851
# text = Sex steroid regulation of the production of this molecule, as well as other cytokines, may help explain the gender-specific differences in the immune system, including autoimmunity.
1	Sex	sex	NOUN	NN	Number=Sing	_	_	_	_
2	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	well	well	ADV	RB	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	help	help	VERB	VB	VerbForm=Inf	_	_	_	_
19	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	gender	gender	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7852
# text = Document 0030011254 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011254	0030011254	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7853
# text = Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.
1	Alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
2	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
10	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
11	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
16	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7854
# text = The gene encoding the 105-kDa protein (p105) precursor of the p50 subunit of transcription factor NF-kappa B also encodes a p70
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	p70	p70	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7855
# text = I kappa B protein, I kappa B gamma, which is identical to the C-terminal 607 amino acids of p105.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
18	607	607	NUM	CD	NumType=Card	_	_	_	_
19	amino	amino	DET	DT	_	_	_	_	_
20	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7856
# text = Here we show that alternative RNA splicing generates I kappa B gamma isoforms with properties different from those of p70.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
6	RNA	RNA	NOUN	NN	Number=Sing	_	_	_	_
7	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
8	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7857
# text = One 63-kDa isoform, termed I kappa B gamma-1, which lacks 59 amino acids C-terminal to ankyrin repeat 7, has a novel 35-amino acid C terminus encoded by an alternative reading frame of the p105 gene.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	63	63	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
5	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	59	59	NUM	CD	NumType=Card	_	_	_	_
18	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
19	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
20	C-	C-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	ankyrin	ankyrin	ADV	RB	_	_	_	_	_
24	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	_
25	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
30	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	amino	amino	DET	DT	_	_	_	_	_
33	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
34	C	c	NOUN	NN	Number=Sing	_	_	_	_
35	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
36	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
40	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
41	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7858
# text = A 55-kDa isoform, I kappa B gamma-2, lacks the 190 C-terminal amino acids of p70I kappa B gamma.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	55	55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
5	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	190	190	NUM	CD	NumType=Card	_	_	_	_
17	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	amino	amino	DET	DT	_	_	_	_	_
20	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7859
# text = In contrast to p70I kappa
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7860
# text = B gamma, which is a cytoplasmic protein, I kappa B gamma-1 is found in both the cytoplasm and nucleus, whereas I kappa B gamma-2 is predominantly nuclear.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	nucleus	nucleus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	predominantly	predominantly	ADV	RB	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7861
# text = The I kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7862
# text = B gamma isoforms also display differences in specificity and affinity for Rel/NF-kappa B proteins.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	display	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7863
# text = While p70I kappa
1	While	while	SCONJ	IN	_	_	_	_	_
2	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7864
# text = B gamma inhibits p50-, p65-, and c-Rel-mediated transactivation and/or DNA binding, both I kappa B gamma-1 and I kappa B gamma-2 are specific for p50 and have different affinities for this subunit.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-,	-,	PUNCT	.	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel-mediated	Rel-mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	or	or	CCONJ	CC	_	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	p50	p50	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
41	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7865
# text = The absence in I kappa B gamma-1 and I kappa B gamma-2 of a protein kinase A site whose phosphorylation modulates p70I kappa B gamma inhibitory activity suggests that alternative RNA splicing may be used to generate I kappa B gamma isoforms that respond differently to intracellular signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	modulates	modulate	NOUN	NNS	Number=Plur	_	_	_	_
26	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
28	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
29	B	b	X	GW	_	_	_	_	_
30	gamma	gamma	X	FW	Foreign=Yes	_	_	_	_
31	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
36	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
37	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
40	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
44	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
45	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
46	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
47	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
48	that	that	PRON	WDT	PronType=Rel	_	_	_	_
49	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	differently	differently	ADV	RB	_	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
53	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7866
# text = Document 0030011255 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011255	0030011255	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7867
# text = Stimulation of interleukin-1 alpha and interleukin-1 beta production in human monocytes by protein phosphatase 1 and 2A inhibitors.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	A	a	NOUN	NN	Number=Sing	_	_	_	_
23	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7868
# text = Protein phosphatases 1 and 2A are important in regulating cellular functions by controlling the phosphorylation state of their substrates.
1	Protein	protein	PROPN	NNP	Number=Sing	_	_	_	_
2	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	A	a	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	state	state	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7869
# text = In human monocytes, the inhibitors of these phosphatases, okadaic acid and calyculin A, were found to increase the mRNA accumulation and cytokine production of interleukin-1 beta and interleukin-1 alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	calyculin	calyculin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
23	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	production	production	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7870
# text = The increased mRNA accumulation was found to be primarily because of the increase in the transcription rate of the interleukin-1 genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
4	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	primarily	primarily	ADV	RB	_	_	_	_	_
10	because	because	ADP	IN	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7871
# text = Stimulation of interleukin-1 gene transcription may be caused by the stimulation of transcription factor activities, including those of AP-1, by these protein phosphatase inhibitors.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
20	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
30	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7872
# text = Okadaic acid increased the synthesis of the interleukin-1 beta precursor and mature forms and their secretion.
1	Okadaic	Okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
15	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7873
# text = This increased processing and secretion correlated with the stimulation of IL-1 beta convertase mRNA accumulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	convertase	convertase	NOUN	NN	Number=Sing	_	_	_	_
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
17	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7874
# text = The stimulation of interleukin-1 alpha production by okadaic acid was more modest than that of interleukin-1 beta.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
11	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	more	more	ADV	RBR	_	_	_	_	_
14	modest	modest	ADJ	JJ	Degree=Pos	_	_	_	_
15	than	than	ADP	IN	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7875
# text = However, the phosphorylation of the precursor interleukin-1 alpha cytokine was increased.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7876
# text = These results show that protein phosphatase 1 and 2A inhibitors exert multiple effects on cytokine production in human monocytes and suggest that these two phosphatases play important roles in regulating interleukin-1 production.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	A	a	NOUN	NN	Number=Sing	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
12	exert	exert	ADP	IN	Typo=Yes	_	_	_	_
13	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
14	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
27	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	SCONJ	IN	_	_	_	_	_
31	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7877
# text = Document 0030011257 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011257	0030011257	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7878
# text = Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter: evidence for the role of Sp1 and not of c-Myb or PU.1 in myelomonocytic lineage-specific expression.
1	Structure	structure	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7879
# text = The human myeloid nuclear differentiation antigen (MNDA) is expressed specifically in maturing cells of the myelomonocytic lineage and in monocytes and granulocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MNDA	MNDA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	maturing	mature	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7880
# text = Epitope enhancement was used to confirm the strict lineage- and stage-specific expression of MNDA in bone marrow as well as in other paraffin-embedded fixed tissues.
1	Epitope	Epitope	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	strict	strict	ADJ	JJ	Degree=Pos	_	_	_	_
9	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MNDA	MNDA	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
20	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	paraffin-	paraffin-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	embedded	embedd	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7881
# text = A 1-kb region of the gene that includes 5' flanking sequence was reported earlier to contain functional promoter activity and was specifically demethylated in expressing cells in contrast to null cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	'	'	PUNCT	``	_	_	_	_	_
13	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	specifically	specifically	ADV	RB	_	_	_	_	_
26	demethylated	demethylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	expressing	expresse	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	null	null	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7882
# text = Further analysis has revealed that this 1-kb fragment promotes higher reporter gene activity in MNDA-expressing cells than non-expressing cells, indicating cell-specific differences in transactivation.
1	Further	further	ADV	RB	_	_	_	_	_
2	analysis	analysis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
10	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
11	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	MNDA	MNDA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	than	than	ADP	IN	_	_	_	_	_
22	non-expressing	non-expresse	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7883
# text = This sequence contains consensus elements consistent with myeloid-specific gene expression, including a PU.1 consensus site near the major transcription start site and a cluster of c-Myb sites located several hundred bases upstream of this region.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consensus	consensus	ADJ	JJ	Degree=Pos	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
17	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	near	near	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	start	start	NOUN	NN	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
35	hundred	hundred	NUM	CD	NumType=Card	_	_	_	_
36	bases	base	NOUN	NNS	Number=Plur	_	_	_	_
37	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
40	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7884
# text = However, analysis of deletion mutants localized nearly all of the promoter activity to a short region (-73 to -16) that did not include the cluster of c-Myb sites.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
6	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
7	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	nearly	nearly	ADV	RB	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
19	73	73	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7885
# text = A 4-bp mutation of the core Sp1 consensus element (GC box) (-20) reduced overall promoter activity of the 1-kb fragment.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
10	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
14	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
17	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
28	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7886
# text = Mutation of the PU.1 site did not significantly affect promoter activity.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7887
# text = Only a small region (-35 to +22) including the Sp1 element and transcription start site, but not the PU.1 site was footprinted.
1	Only	only	ADV	RB	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	-35	-35	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
9	22	22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	start	start	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	footprinted	footprint	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7888
# text = The 4-bp mutation of the core Sp1 consensus element abolished footprinting at the site and an antibody super-shift reaction showed that Sp1 is one of the factors binding the consensus site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
10	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
20	super	super	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	shift	shift	ADJ	JJ	Degree=Pos	_	_	_	_
23	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	one	one	NUM	CD	NumType=Card	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7889
# text = The Sp1 site also co-localizes with a DNase I hypersensitive site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	co-localizes	co-localize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7890
# text = The results indicate that DNA methylation, chromatin structure, and transactivation at an Sp1 site contribute to the highly restricted expression of this myelomonocytic lineage specific gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
9	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	highly	highly	ADV	RB	_	_	_	_	_
21	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7891
# text = Document 0030011258 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011258	0030011258	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7892
# text = Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	FKHRL1	FKHRL1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	P2	p2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	member	member	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	developmentally	developmentally	ADV	RB	_	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	fork	fork	NOUN	NN	Number=Sing	_	_	_	_
14	head	head	NOUN	NN	Number=Sing	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7893
# text = Here we report the expression of a fork head domain protein in human T helper cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	fork	fork	NOUN	NN	Number=Sing	_	_	_	_
9	head	head	NOUN	NN	Number=Sing	_	_	_	_
10	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7894
# text = We cloned and characterized a fork head cDNA from human T helper cell mRNA using differential display RT-PCR.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	cloned	clon	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	fork	fork	NOUN	NN	Number=Sing	_	_	_	_
7	head	head	NOUN	NN	Number=Sing	_	_	_	_
8	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
17	display	display	NOUN	NN	Number=Sing	_	_	_	_
18	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7895
# text = The cDNA contains a 546-nucleotide (nt) open reading frame (ORF) that codes for the carboxyl-terminal 180 amino acids (aa) of the recently identified fkhrl1 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	546	546	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-nucleotide	-nucleotide	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	nt	not	PART	RB	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
11	reading	read	NOUN	NN	Number=Sing	_	_	_	_
12	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	ORF	ORF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	codes	code	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
23	180	180	NUM	CD	NumType=Card	_	_	_	_
24	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
25	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	aa	aa	INTJ	UH	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	recently	recently	ADV	RB	_	_	_	_	_
32	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	fkhrl1	fkhrl1	NUM	CD	NumType=Card	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7896
# text = This ORF does not contain the characteristic DNA-binding domain found in members of the forkhead protein family.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	ORF	Orf	NOUN	NN	Number=Sing	_	_	_	_
3	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	members	member	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	forkhead	forkhead	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7897
# text = In-vitro transcription/translation of this cDNA expressed a protein of approximately 20 kDa.
1	In	in	ADP	IN	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
10	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	20	20	NUM	CD	NumType=Card	_	_	_	_
16	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7898
# text = We have generated antibodies that specifically immunoprecipitated the in-vitro-translated 20-kDa protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	specifically	specifically	ADV	RB	_	_	_	_	_
7	immunoprecipitated	immunoprecipitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	in-	in-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	vitro-translated	vitro-translated	ADJ	JJ	Degree=Pos	_	_	_	_
11	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7899
# text = This antibody also recognizes in human T lymphocytes a 70-kDa protein corresponding in size to that predicted for the fkhrl1 gene product.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	size	size	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
19	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	fkhrl1	fkhrl1	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7900
# text = The mRNA levels for fkhrl1 is elevated in T helper-induced lymphocytes in comparison to PHA-stimulated T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	fkhrl1	fkhrl1	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	helper	helper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7901
# text = Further characterization of FKHRL1 and its related family members should shed light on the transcriptional mechanisms of this fork head gene subfamily and their role in T helper cell differentiation and regulation of cell growth.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	FKHRL1	Fkhrl1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
7	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
12	shed	shed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	light	light	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	fork	fork	NOUN	NN	Number=Sing	_	_	_	_
21	head	head	NOUN	NN	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	subfamily	subfamily	ADV	RB	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7902
# text = Document 0030011260 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011260	0030011260	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7903
# text = The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	19	19	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	target	target	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7904
# text = The CD19 protein is expressed on the surface of all B-lymphoid cells with the exception of terminally differentiated plasma cells and has been implicated as a signal-transducing receptor in the control of proliferation and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	19	19	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	terminally	terminally	ADV	RB	_	_	_	_	_
21	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	transducing	transducing	VERB	VBG	VerbForm=Ger	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	control	control	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7905
# text = Here we demonstrate complete correlation between the expression pattern of the CD19 gene and the B-cell-specific transcription factor BSAP in a large panel of B-lymphoid cell lines.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
5	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	19	19	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
27	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7906
# text = The human CD19 gene has been cloned, and several BSAP-binding sites have been mapped by in vitro protein-DNA binding studies.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	19	19	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7907
# text = In particular, a high-affinity BSAP-binding site instead of a TATA sequence is located in the -30 promoter region upstream of a cluster of heterogeneous transcription start sites.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
8	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	instead	instead	ADV	RB	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	TATA	TATA	NOUN	NN	Number=Sing	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	30	30	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	start	start	NOUN	NN	Number=Sing	_	_	_	_
33	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7908
# text = Moreover, this site is occupied by BSAP in vivo in a CD19-expressing B-cell line but not in plasma or HeLa cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	CD19	CD19	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-expressing	-expressing	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	HeLa	Hela	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7909
# text = This high-affinity site has been conserved in the promoters of both human and mouse CD19 genes and was furthermore shown to confer B-cell specificity to a beta-globin reporter gene in transient transfection experiments.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	human	human	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
17	CD	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	19	19	NUM	CD	NumType=Card	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	furthermore	furthermore	ADV	RB	_	_	_	_	_
23	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
35	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
39	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
40	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7910
# text = In addition, BSAP was found to be the only abundant DNA-binding activity of B-cell nuclear extracts that interacts with the CD19 promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
11	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	19	19	NUM	CD	NumType=Card	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7911
# text = Together, this evidence strongly implicates BSAP in the regulation of the CD19 gene.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	strongly	strongly	ADV	RB	_	_	_	_	_
6	implicates	implicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	19	19	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7912
# text = Document 0030011261 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011261	0030011261	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7913
# text = Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation.
1	Simple	simple	ADJ	JJ	Degree=Pos	_	_	_	_
2	derivation	derivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TFIID	TFIID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
8	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
9	II	ii	NUM	CD	NumType=Card	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	Schizosaccharomyces	Schizosaccharomyce	NOUN	NNS	Number=Plur	_	_	_	_
14	pombe	pombe	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7914
# text = Resolution of whole cell extract through two chromatographic steps yields a single protein fraction requiring only the addition of TFIID for the initiation of transcription at RNA polymerase II promoters.
1	Resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	chromatographic	chromatographic	ADJ	JJ	Degree=Pos	_	_	_	_
9	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
10	yields	yield	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
15	requiring	require	VERB	VBG	VerbForm=Ger	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	TFIID	tFIId	PROPN	NNP	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
28	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7915
# text = This approach allows the convenient generation of RNA polymerase II transcription systems from Saccharomyces cerevisiae, human lymphocytes, and Schizosaccharomyces pombe.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
3	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	convenient	convenient	ADJ	JJ	Degree=Pos	_	_	_	_
6	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
9	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	Saccharomyces	Saccharomyce	NOUN	NNS	Number=Plur	_	_	_	_
15	cerevisiae	cerevisia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Schizosaccharomyces	Schizosaccharomyce	NOUN	NNS	Number=Plur	_	_	_	_
22	pombe	pombe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7916
# text = TFIIDs from all three organisms are interchangeable among all three systems.
1	TFIIDs	TFIid	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	interchangeable	interchangeable	ADJ	JJ	Degree=Pos	_	_	_	_
8	among	among	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7917
# text = The S. cerevisiae and Sch. pombe systems support effects of acidic activator proteins, provided a further protein fraction from S. cerevisiae is supplied.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
3	cerevisiae	cerevisia	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Sch	Sch	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_
7	pombe	pombe	ADJ	JJ	Degree=Pos	_	_	_	_
8	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
9	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	provided	provide	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
23	cerevisiae	cerevisiae	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	supplied	supply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7918
# text = This further fraction is distinct from the mediator of transcriptional activation described previously and represents a second component in addition to general initiation factors that may facilitate a response to acidic activators.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	described	describe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	component	component	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
23	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
32	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7919
# text = Document 0030011269 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011269	0030011269	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7920
# text = Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes.
1	Hypoxia	Hypoxia	PROPN	NNP	Number=Sing	_	_	_	_
2	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acidosis	acidosis	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	proteasomes	proteasome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7921
# text = Intercellular adhesion molecule 1 (ICAM-1) is an important molecule in promotion of polymorphonuclear neutrophil transendothelial migration during inflammation.
1	Intercellular	Intercelular	ADJ	JJ	Degree=Pos	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	X	LS	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	promotion	promotion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
19	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
20	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7922
# text = Coincident with many inflammatory diseases is tissue hypoxia.
1	Coincident	Coincident	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
4	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
8	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7923
# text = Thus we hypothesized that combinations of hypoxia and inflammatory stimuli may differentially regulate expression of endothelial ICAM-1.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	differentially	differentially	ADV	RB	_	_	_	_	_
13	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7924
# text = Human endothelial cells were exposed to hypoxia in the presence or absence of added lipopolysaccharide (LPS) and examined for expression of functional ICAM-1.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
25	ICAM	ICAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7925
# text = Although hypoxia alone did not induce ICAM-1, the combination of LPS and hypoxia enhanced (3 +/- 0.4-fold over normoxia) ICAM-1 expression.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	hypoxia	hypoxia	NOUN	NNS	Number=Plur	_	_	_	_
3	alone	alone	ADV	RB	_	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
7	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	+/-	+/-	SYM	SYM	_	_	_	_	_
21	0.4	0.4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
24	over	over	ADP	IN	_	_	_	_	_
25	normoxia	normoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7926
# text = Combinations of hypoxia and LPS significantly increased lymphocyte binding, and such increases were inhibited by addition of anti-ICAM-1 antibodies or antisense oligonucleotides.
1	Combinations	Combination	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	significantly	significantly	ADV	RB	_	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	anti-ICAM	anti-icam	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
25	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7927
# text = Hypoxic endothelia showed a > 10-fold increase in sensitivity to inhibitors of proteasome activation, and combinations of hypoxia and LPS enhanced proteasome-dependent cytoplasmic-to-nuclear localization of the nuclear transcription factor-kappa B p65 (Rel A) subunit.
1	Hypoxic	Hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
2	endothelia	endothelia	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	>	>	SYM	$	_	_	_	_	_
6	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	proteasome	proteasome	DET	DT	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	proteasome	proteasome	ADV	RB	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
31	-nuclear	-nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	p65	p65	NUM	CD	NumType=Card	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
44	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7928
# text = Such proteasome activation correlated with hypoxia-evoked decreases in both extracellular and intracellular pH.
1	Such	such	DET	PDT	_	_	_	_	_
2	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	evoked	evok	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	pH	ph	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7929
# text = We conclude from these studies that endothelial hypoxia provides a novel, proteasome-dependent stimulus for ICAM-1 induction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
9	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	proteasome	proteasome	ADV	RB	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	ICAM	ICAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7930
# text = Document 0030011270 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011270	0030011270	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7931
# text = Expression of c-fos correlates with IFN-alpha responsiveness in Philadelphia chromosome positive chronic myelogenous leukemia.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Philadelphia	Philadelphia	PROPN	NNP	Number=Sing	_	_	_	_
14	chromosome	chromosome	PROPN	NNP	Number=Sing	_	_	_	_
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
17	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
18	leukemia	leukemion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7932
# text = This study evaluates (i) constitutive levels of oncogene and p53 transcripts in chronic phase CML patients and (ii) their modulations subsequent to in vivo therapy with rIFN-alpha 2c.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	evaluates	evaluate	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
13	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
16	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
17	CML	cml	NOUN	NN	Number=Sing	_	_	_	_
18	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	modulations	modulation	NOUN	NNS	Number=Plur	_	_	_	_
25	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
29	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	rIFN	rIFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	2c	2c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7933
# text = Peripheral blood mononuclear cells (pbmc) and bone marrow cells of 26 patients were examined for c-fos, c-myc, p53 and the hybrid bcr/abl mRNA levels.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	pbmc	pbmc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	bone	bone	PRON	NN	Number=Sing	_	_	_	_
10	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	26	26	NUM	CD	NumType=Card	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	p53	p53	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
27	bcr/	bcr/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
28	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
29	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7934
# text = Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl, c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	transcript	transcript	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	significantly	significantly	ADV	RB	_	_	_	_	_
15	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	subsequently	subsequently	ADV	RB	_	_	_	_	_
19	responding	respond	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	p	p	NOUN	NN	Number=Sing	_	_	_	_
27	<	<	PUNCT	-LRB-	_	_	_	_	_
28	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	positively	positively	ADV	RB	_	_	_	_	_
32	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	r	be	NOUN	NN	Number=Sing	_	_	_	_
40	=	=	SYM	SYM	_	_	_	_	_
41	0.6895	0.6895	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	p	p	NOUN	NN	Number=Sing	_	_	_	_
44	<	<	PUNCT	-LRB-	_	_	_	_	_
45	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	negatively	negatively	ADV	RB	_	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	r	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
57	=	=	SYM	SYM	_	_	_	_	_
58	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
59	0.568	0.568	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	,	,	PUNCT	,	_	_	_	_	_
61	p	p	NOUN	NN	Number=Sing	_	_	_	_
62	<	<	PUNCT	-LRB-	_	_	_	_	_
63	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
66	in	in	ADP	IN	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	pbmc	pbmc	NOUN	NN	Number=Sing	_	_	_	_
69	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	_
70	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
71	,	,	PUNCT	,	_	_	_	_	_
72	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
73	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
74	)	)	PUNCT	-RRB-	_	_	_	_	_
75	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
76	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
77	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
78	of	of	ADP	IN	_	_	_	_	_
79	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
80	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
81	bcr/	bcr/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
82	abl	abl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	,	,	PUNCT	,	_	_	_	_	_
84	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	_
85	and	and	CCONJ	CC	_	_	_	_	_
86	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
87	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
88	positively	positively	ADV	RB	_	_	_	_	_
89	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
90	with	with	ADP	IN	_	_	_	_	_
91	each	each	DET	DT	_	_	_	_	_
92	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
93	,	,	PUNCT	,	_	_	_	_	_
94	but	but	CCONJ	CC	_	_	_	_	_
95	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
96	to	to	PART	TO	_	_	_	_	_
97	relate	relate	VERB	VB	VerbForm=Inf	_	_	_	_
98	to	to	ADP	IN	_	_	_	_	_
99	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
100	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
101	,	,	PUNCT	,	_	_	_	_	_
102	and	and	CCONJ	CC	_	_	_	_	_
103	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
104	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
105	)	)	PUNCT	-RRB-	_	_	_	_	_
106	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
107	and	and	CCONJ	CC	_	_	_	_	_
108	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
109	in	in	ADP	IN	_	_	_	_	_
110	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
111	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
112	to	to	ADP	IN	_	_	_	_	_
113	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
114	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
115	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
116	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
117	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
118	by	by	ADP	IN	_	_	_	_	_
119	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
120	of	of	ADP	IN	_	_	_	_	_
121	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
122	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
123	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
124	and	and	CCONJ	CC	_	_	_	_	_
125	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
126	of	of	ADP	IN	_	_	_	_	_
127	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
128	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
129	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
130	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
131	in	in	ADP	IN	_	_	_	_	_
132	responder	responder	NOUN	NN	Number=Sing	_	_	_	_
133	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
134	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7935
# text = Document 0030011271 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011271	0030011271	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7936
# text = IL-4 down-regulates IL-2-, IL-3-, and GM-CSF-induced cytokine gene expression in peripheral blood monocytes.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
3	4	4	X	GW	_	_	_	_	_
4	down	down	X	GW	_	_	_	_	SpaceAfter=No
5	-	-	X	GW	_	_	_	_	SpaceAfter=No
6	regulates	regulate	X	GW	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
28	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7937
# text = IL-4, a product of the T-helper 0 (Th0) and 2 (Th2) subset, was originally described as a B-cell stimulatory factor and has subsequently been found to suppress IL-1 alpha, IL-1 beta, IL-6, IL-8, and TNF-alpha gene expression in monocytes stimulated with LPS, and to upregulate IL-1 receptor antagonist (IL1-RA) gene expression.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	product	product	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
11	0	0	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Th0	Th0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	Th2	Th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	subset	subset	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	originally	originally	ADV	RB	_	_	_	_	_
24	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	stimulatory	stimulatory	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	subsequently	subsequently	ADV	RB	_	_	_	_	_
35	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
51	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
61	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
62	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
65	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
66	with	with	ADP	IN	_	_	_	_	_
67	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	and	and	CCONJ	CC	_	_	_	_	_
70	to	to	ADP	IN	_	_	_	_	_
71	upregulate	upregulate	ADJ	JJ	Degree=Pos	_	_	_	_
72	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
73	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
74	1	1	NUM	CD	NumType=Card	_	_	_	_
75	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
76	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
77	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
78	IL1	Il1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
80	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
81	)	)	PUNCT	-RRB-	_	_	_	_	_
82	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
83	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
84	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7938
# text = In this study we investigated the effect of IL-4 on the expression of cytokine genes in monocytes evoked by other T-helper cell cytokines: IL-2, IL-3, and GM-CSF.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	evoked	evok	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	:	:	PUNCT	:	_	_	_	_	_
28	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7939
# text = IL-4 down-regulated mRNA accumulation of the proinflammatory cytokines IL-1 beta, IL-8, and TNF-alpha in monocytes stimulated with IL-2, IL-3, and GM-CSF.
1	IL	Il	SYM	$	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7940
# text = IL-4 also suppressed the IL-2-induced IL-6 mRNA expression.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7941
# text = Temporal analysis of the IL-4 down-regulatory effect on the IL-2-, IL-3-, or GM-CSF-induced proinflammatory cytokine gene expression in monocytes provided evidence that IL-4 acts predominantly on the post-transcriptional level.
1	Temporal	Temporal	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	4	4	NUM	CD	NumType=Card	_	_	_	_
42	acts	acts	NOUN	NNS	Number=Plur	_	_	_	_
43	predominantly	predominantly	ADV	RB	_	_	_	_	_
44	on	on	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	post	post	X	AFX	_	_	_	_	SpaceAfter=No
47	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
48	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7942
# text = This was supported by the observation that the down-regulatory capacity of IL-4 appeared to be dependent on de novo protein synthesis.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	supported	support	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	de	de	NOUN	NN	Number=Sing	_	_	_	_
23	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7943
# text = IL-4 did not exert significant influence on the induction of expression of IL-1-RA or various CSFs by IL-2, IL-3, and GM-CSF.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
7	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
8	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
22	CSFs	CSF	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7944
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7945
# text = Document 0030011272 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011272	0030011272	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7946
# text = I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	masks	mask	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7947
# text = The active nuclear form of the NF-kappa B transcription factor complex is composed of two DNA binding subunits, NF-kappa B p65 and NF-kappa B p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	form	form	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	both	both	CCONJ	CC	_	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	which	which	DET	WDT	PronType=Int	_	_	_	_
37	share	share	NOUN	NN	Number=Sing	_	_	_	_
38	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
39	N-	N-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
41	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
42	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
46	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
47	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
48	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7948
# text = The NF-kappa B p65 subunit provides the transactivation activity in this complex and serves as an intracellular receptor for a cytoplasmic inhibitor of NF-kappa B, termed I kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	p65	p65	NUM	CD	NumType=Card	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
24	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7949
# text = In contrast, NF-kappa B p50 alone fails to stimulate kappa B-directed transcription, and based on prior in vitro studies, is not directly regulated by I kappa B.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	p50	p50	NUM	CD	NumType=Card	_	_	_	_
9	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
10	fails	fail	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
25	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	directly	directly	ADV	RB	_	_	_	_	_
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7950
# text = To investigate the molecular basis for the critical regulatory interaction between NF-kappa B and I kappa B/MAD-3, a series of human NF-kappa B p65 mutants was identified that functionally segregated DNA binding, I kappa B-mediated inhibition, and I kappa B-induced nuclear exclusion of this transcription factor.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	series	series	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	p65	p65	NUM	CD	NumType=Card	_	_	_	_
34	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	functionally	functionally	ADV	RB	_	_	_	_	_
39	segregated	segregate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
41	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
45	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
46	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
51	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
52	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
56	exclusion	exclusion	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
59	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
60	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7951
# text = Results from in vivo expression studies performed with these NF-kappa B p65 mutants revealed the following:
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	p65	p65	NUM	CD	NumType=Card	_	_	_	_
15	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
16	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 7952
# text = 1) I kappa B/MAD-3 completely inhibits NF-kappa B p65-dependent transcriptional activation mediated through the human immunodeficiency virus type 1 kappa
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/MAD	/MAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	completely	completely	ADV	RB	_	_	_	_	_
10	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 7953
# text = B enhancer in human T lymphocytes, 2) the binding of I kappa B/MAD-3 to NF-kappa B p65 is sufficient to retarget NF-kappa B p65 from the nucleus to the cytoplasm, 3) selective deletion of the functional nuclear localization signal present in the Rel homology domain of NF-kappa B p65 disrupts its ability to engage I kappa B/MAD-3, and 4) the unique C-terminus of NF-kappa B p65 attenuates its own nuclear localization and contains sequences that are required for I kappa B-mediated inhibition of NF-kappa B p65 DNA binding activity.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	2	2	X	LS	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	/MAD	/MAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	retarget	retarget	VERB	VB	VerbForm=Inf	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	3	3	X	LS	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
44	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
48	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
49	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
50	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
51	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
55	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
56	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
61	B	b	NOUN	NN	Number=Sing	_	_	_	_
62	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
63	disrupts	disrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
64	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
65	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
66	to	to	PART	TO	_	_	_	_	_
67	engage	engage	VERB	VB	VerbForm=Inf	_	_	_	_
68	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
69	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
70	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
72	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
73	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
74	,	,	PUNCT	,	_	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	4	4	X	LS	_	_	_	_	SpaceAfter=No
77	)	)	PUNCT	-RRB-	_	_	_	_	_
78	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
79	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
80	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
82	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
85	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
86	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
87	B	b	NOUN	NN	Number=Sing	_	_	_	_
88	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
89	attenuates	attenuate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
90	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
91	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
92	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
93	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
94	and	and	CCONJ	CC	_	_	_	_	_
95	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
96	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
97	that	that	PRON	WDT	PronType=Rel	_	_	_	_
98	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
99	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
100	for	for	SCONJ	IN	_	_	_	_	_
101	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
102	kappa	kappa	ADV	RB	_	_	_	_	_
103	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
104	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
105	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
106	of	of	ADP	IN	_	_	_	_	_
107	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
108	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
109	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
110	B	b	NOUN	NN	Number=Sing	_	_	_	_
111	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
112	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
113	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
114	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
115	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7954
# text = Together, these findings suggest that the nuclear localization signal and transactivation domain of NF-kappa B p65 constitute a bipartite system that is critically involved in the inhibitory function of I kappa B/MAD-3.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	p65	p65	NUM	CD	NumType=Card	_	_	_	_
20	constitute	constitute	NOUN	NN	Number=Sing	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	bipartite	bipartite	ADJ	JJ	Degree=Pos	_	_	_	_
23	system	system	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	critically	critically	ADV	RB	_	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
31	function	function	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7955
# text = Unexpectedly, our in vivo studies also demonstrate that I kappa B/MAD-3 binds directly to NF-kappa B p50.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/MAD	/mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	_
16	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
17	directly	directly	ADV	RB	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7956
# text = This interaction is functional as it leads to retargeting of NF-kappa B p50 from the nucleus to the cytoplasm.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
7	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	SCONJ	IN	_	_	_	_	_
9	retargeting	retarget	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7957
# text = However, no loss of DNA binding activity is observed, presumably reflecting the unique C-terminal domain that is distinct from that present in NF-kappa B p65.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	presumably	presumably	ADV	RB	_	_	_	_	_
13	reflecting	reflect	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
16	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
18	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	present	present	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7958
# text = Document 0030011273 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011273	0030011273	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7959
# text = Evaluation of the role of ligand and thermal activation of specific DNA binding by in vitro synthesized human glucocorticoid receptor.
1	Evaluation	evaluation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	thermal	thermal	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
17	synthesized	synthesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7960
# text = We have used a DNA-binding/immunoprecipitation assay to analyze the capacity of human glucocorticoid receptor (hGR), generated in rabbit reticulocyte lysates, to bind DNA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	DNA-	Dna-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
9	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
25	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
26	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7961
# text = In vitro translated hGR was indistinguishable from native hGR, as determined by migration on sodium dodecyl sulfate-polyacrylamide gels, sedimentation on sucrose density gradients, and reactivity with antipeptide antibodies generated against hGR.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
3	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
9	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	SCONJ	IN	_	_	_	_	_
12	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
17	dodecyl	dodecyl	NOUN	NN	Number=Sing	_	_	_	_
18	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
21	gels	gel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	sedimentation	sedimentation	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	sucrose	sucrose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	density	density	NOUN	NN	Number=Sing	_	_	_	_
27	gradients	gradient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	antipeptide	antipeptide	ADJ	JJ	Degree=Pos	_	_	_	_
33	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
34	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	against	against	ADP	IN	_	_	_	_	_
36	hGR	hGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7962
# text = In addition, cell-free synthesized hGR was capable of specific binding to glucocorticoid response element (GRE)-containing DNA fragments.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
7	synthesized	synthesized	ADJ	JJ	Degree=Pos	_	_	_	_
8	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7963
# text = Using this assay system, we have evaluated the contributions of ligand binding and heat activation to DNA binding by these glucocorticoid receptors.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	contributions	contribution	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7964
# text = In vitro translated hGR was capable of selective DNA binding even in the absence of glucocorticoid.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
3	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	even	even	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7965
# text = Treatment with dexamethasone or the antiglucocorticoid RU486 had no additional effect on the DNA-binding capacity when receptor preparations were maintained at 0 C (no activation).
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	antiglucocorticoid	antiglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	RU486	Ru486	PROPN	NNP	Number=Sing	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	receptor	receptor	ADJ	JJ	Degree=Pos	_	_	_	_
20	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	0	0	NUM	CD	NumType=Card	_	_	_	_
25	C	C	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	no	no	DET	DT	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7966
# text = In contrast, addition of either ligand or antagonist in combination with a heat activation step promoted DNA binding by approximately 3-fold over that of heat-activated unliganded receptors.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	step	step	NOUN	NN	Number=Sing	_	_	_	_
17	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	approximately	approximately	ADV	RB	_	_	_	_	_
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	over	over	ADP	IN	_	_	_	_	_
26	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	heat	heat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	unliganded	unliganded	ADJ	JJ	Degree=Pos	_	_	_	_
32	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7967
# text = Agonist (dexamethasone) was slightly more effective in supporting specific DNA binding than antagonist (RU486).
1	Agonist	Agonist	ADJ	JJS	Degree=Sup	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	slightly	slightly	ADV	RB	_	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RU486	RU486	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7968
# text = DNA binding by in vitro synthesized GR was blocked by the addition of sodium molybdate to the receptor preparations before steroid addition and thermal activation.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
6	synthesized	synthesized	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
15	molybdate	molybdate	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	_
20	before	before	ADP	IN	_	_	_	_	_
21	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	thermal	thermal	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7969
# text = Addition of KCl resulted in less DNA binding either due to blockage of DNA-receptor complex formation or disruption of the complexes.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	KCl	KCl	PROPN	NNP	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	due	due	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	blockage	blockage	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7970
# text = The specificity of DNA binding by cell-free synthesized hGR was analyzed further by examining the abilities of various DNAs to compete for binding to a naturally occurring GRE found in the mouse mammary tumor virus-long terminal repeat.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
10	synthesized	synthesized	ADJ	JJ	Degree=Pos	_	_	_	_
11	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	further	further	ADV	RB	_	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	examining	examine	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	abilities	abilitie	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
21	DNAs	Dna	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
24	for	for	SCONJ	IN	_	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	naturally	naturally	ADV	RB	_	_	_	_	_
29	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
30	GRE	Gre	PROPN	NNP	Number=Sing	_	_	_	_
31	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
35	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
40	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
41	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7971
# text = Oligonucleotides containing the consensus GRE were the most efficient competitors, and fragments containing regulatory sequences from glucocorticoid-repressible genes were somewhat competitive, whereas single stranded oligonucleotides were unable to compete for mouse mammary tumor virus-long terminal repeat DNA binding, except when competitor was present at extremely high concentrations.
1	Oligonucleotides	Oligonucleotides	SCONJ	IN	_	_	_	_	_
2	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
5	GRE	GRE	ADV	RB	PronType=Dem	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	most	most	ADV	RBS	_	_	_	_	_
9	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
10	competitors	competitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	repressible	repressible	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	somewhat	somewhat	ADV	RB	_	_	_	_	_
24	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
28	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
36	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
37	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
38	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
41	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
42	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
43	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
44	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	except	except	ADP	IN	_	_	_	_	_
47	when	when	ADV	WRB	PronType=Int	_	_	_	_
48	competitor	competitor	NOUN	NN	Number=Sing	_	_	_	_
49	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
50	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
51	at	at	ADP	IN	_	_	_	_	_
52	extremely	extremely	ADV	RB	_	_	_	_	_
53	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
54	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7972
# text = Together these studies indicate that hGR synthesized in rabbit reticulocyte lysates displays many of the same properties, including GRE-specific DNA binding, observed for glucocorticoid receptor present in cytosolic extracts of mammalian cells and tissues.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	hGR	hGR	PROPN	NNP	Number=Sing	_	_	_	_
7	synthesized	synthesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
10	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
11	lysates	lysate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
20	GRE	Gre	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7973
# text = Similarities between the effects of dexamethasone and RU486 suggest that the antiglucocorticoid properties of RU486 do not occur at the level of specific DNA binding.
1	Similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	RU486	RU486	PROPN	NNP	Number=Sing	_	_	_	_
9	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	antiglucocorticoid	antiglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	RU486	Ru486	NUM	CD	NumType=Card	_	_	_	_
16	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7974
# text = Document 0030011281 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011281	0030011281	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7975
# text = Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.
1	Thrombin	Thrombin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	p65	p65	NUM	CD	NumType=Card	_	_	_	_
4	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
18	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7976
# text = We investigated the mechanisms by which proinflammatory mediator, thrombin, released during intravascular coagulation and tissue injury, induces ICAM-1 (CD54) expression in endothelial cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	DET	WDT	PronType=Int	_	_	_	_
7	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	released	release	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	intravascular	intravascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
18	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
21	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CD54	CD54	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7977
# text = Stimulation of HUVEC with thrombin resulted in dose- and time-dependent increases in ICAM-1 mRNA and cell surface expression and in ICAM-1-dependent endothelial adhesivity toward polymorphonuclear leukocytes.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	thrombin	thrombin	ADP	IN	_	_	_	_	_
6	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
32	adhesivity	adhesivity	NOUN	NN	Number=Sing	_	_	_	_
33	toward	toward	ADP	IN	_	_	_	_	_
34	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7978
# text = Transient transfection of endothelial cells with ICAM-1 promoter luciferase reporter gene (ICAM-1LUC) constructs indicated that deletion of upstream NF-kappa B site (-533 bases from translation start site) had no effect on thrombin responsiveness, whereas mutation/deletion of downstream NF-kappa B site (-223 bases from the translation start site) prevented the activation of ICAM-1 promoter, indicating that the downstream NF-kappa B site is critical for thrombin inducibility.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-1LUC	-1luc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
19	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	_
29	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
30	533	533	NUM	CD	NumType=Card	_	_	_	_
31	bases	base	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
34	start	start	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	no	no	DET	DT	_	_	_	_	_
39	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
42	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	whereas	whereas	SCONJ	IN	_	_	_	_	_
45	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
50	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
53	B	b	NOUN	NN	Number=Sing	_	_	_	_
54	site	site	NOUN	NN	Number=Sing	_	_	_	_
55	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
56	223	223	NUM	CD	NumType=Card	_	_	_	_
57	bases	base	NOUN	NNS	Number=Plur	_	_	_	_
58	from	from	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
61	start	start	NOUN	NN	Number=Sing	_	_	_	_
62	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	)	)	PUNCT	-RRB-	_	_	_	_	_
64	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	1	1	NUM	CD	NumType=Card	_	_	_	_
71	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
74	that	that	SCONJ	IN	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
77	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
79	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
80	B	b	NOUN	NN	Number=Sing	_	_	_	_
81	site	site	NOUN	NN	Number=Sing	_	_	_	_
82	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
83	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
84	for	for	ADP	IN	_	_	_	_	_
85	thrombin	thrombin	ADP	IN	_	_	_	_	_
86	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
87	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7979
# text = NF-kappa B-directed luciferase activity increased approximately 3-fold when cells transfected with the plasmid pNF-kappa BLUC containing five copies of consensus NF-kappa B site linked to a minimal adenovirus E1B promoter-luciferase gene were exposed to thrombin, indicating that activation of NF-kappa B was essential for thrombin response.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	approximately	approximately	ADV	RB	_	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
20	pNF	pNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	BLUC	BLUC	NOUN	NN	Number=Sing	_	_	_	_
24	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
25	five	five	NUM	CD	NumType=Card	_	_	_	_
26	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
38	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
39	E1B	E1b	NOUN	NN	Number=Sing	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
50	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
51	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
56	B	b	PROPN	NNP	Number=Sing	_	_	_	_
57	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
58	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
59	for	for	ADP	IN	_	_	_	_	_
60	thrombin	thrombin	ADP	IN	_	_	_	_	_
61	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7980
# text = Gel supershift assays demonstrated that thrombin induced binding of NF-kappa Bp65 (Rel A) to downstream NF-kappa B site of the ICAM-1 promoter.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	supershift	supershift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	thrombin	thrombin	ADP	IN	_	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	Bp65	Bp65	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
16	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7981
# text = Thrombin receptor activation peptide, a 14-amino-acid peptide representing the new NH2 terminus of proteolytically activated receptor-1, mimicked thrombin's action in inducing ICAM-1 expression.
1	Thrombin	Thrombin	ADP	IN	_	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
16	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	_
17	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	proteolytically	proteolytically	ADV	RB	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	's	's	PART	POS	_	_	_	_	_
28	action	action	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	SCONJ	IN	_	_	_	_	_
30	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
31	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7982
# text = These data indicate that thrombin activates endothelial ICAM-1 expression and polymorphonuclear leukocyte adhesion by NF-kappa Bp65 binding to the downstream NF-kappa B site of ICAM-1 promoter after proteolytically activated receptor-1 activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	thrombin	thrombin	NOUN	NN	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
15	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	Bp65	Bp65	PROPN	NNP	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	proteolytically	proteolytically	ADV	RB	_	_	_	_	_
37	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-1	-1	NUM	CD	NumType=Card	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7983
# text = Document 0030011282 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011282	0030011282	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7984
# text = Constitutive expression c-fos, c-jun, and NF kappa B mRNA is in nucleated fetal blood cells and up-regulation of c-fos and c-jun with anti-CD3 stimulation.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	B	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	nucleated	nucleated	ADJ	JJ	Degree=Pos	_	_	_	_
17	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7985
# text = Fetal and neonatal lymphocytes are relatively resistant to activation and cytokine production when stimulated either via their T-cell antigen receptors or lectins.
1	Fetal	Fetal	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	relatively	relatively	ADV	RB	_	_	_	_	_
7	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	when	when	ADV	WRB	PronType=Int	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	either	either	ADV	RB	_	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	lectins	lectin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7986
# text = The molecular mechanism(s) responsible for this phenomenon have not been clearly elucidated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	s	s	X	AFX	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	clearly	clearly	ADV	RB	_	_	_	_	_
15	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7987
# text = We have hypothesized that such defects in fetal/neonatal T-cell activation may be due to lack of expression of the transcriptional regulatory elements required for T-cell activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	hypothesized	hypothesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7988
# text = We used reverse transcriptase-polymerase chain reaction to examine both fetal and term neonatal cord bloods for mRNA expression of three transcription factors implicated in T-cell activation:
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
4	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	examine	examine	NOUN	NN	Number=Sing	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	fetal	fetal	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	term	term	NOUN	NN	Number=Sing	_	_	_	_
15	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
16	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
17	bloods	blood	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	three	three	NUM	CD	NumType=Card	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 7989
# text = c-jun, c-fos, and NF kappa B (p50 subunit).
1	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	p50	p50	NUM	CD	NumType=Card	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7990
# text = We demonstrate that mRNAs for all three of these regulatory factors are expressed in fetal blood cells by the 27th week of gestation and in term cord bloods.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	27th	27th	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
21	week	week	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	gestation	gestation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	term	term	NOUN	NN	Number=Sing	_	_	_	_
27	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
28	bloods	bloods	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7991
# text = Activation of term infant cord blood mononuclear cells with anti-CD3 monoclonal antibodies resulted in up-regulation of both c-jun and c-fos mRNAs within 15 min of stimulation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	term	term	NOUN	NN	Number=Sing	_	_	_	_
4	infant	infant	NOUN	NN	Number=Sing	_	_	_	_
5	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
11	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
13	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
26	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
27	within	within	ADP	IN	_	_	_	_	_
28	15	15	NUM	CD	NumType=Card	_	_	_	_
29	min	min	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7992
# text = However, secretion of IL-2 by anti-CD3-stimulated cord blood mononuclear cells was still blunted compared with control cells from adults.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-stimulated	-stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
11	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	still	still	ADV	RB	_	_	_	_	_
17	blunted	blunt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7993
# text = We conclude that fetal nucleated blood cells constitutively express important genes for cytokine regulation and are able to increase intracellular accumulation of the mRNAs for these factors in response to anti-CD3 stimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
5	nucleated	nucleate	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
32	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7994
# text = Thus, qualitative differences in the capacity to regulate these factors could not be shown in fetal blood cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	qualitative	qualitative	ADJ	JJ	Degree=Pos	_	_	_	_
4	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7995
# text = Quantitative experiments comparing binding of these transcription factors to the IL-2 promoter are currently under investigation.
1	Quantitative	Quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	comparing	compare	VERB	VBG	VerbForm=Ger	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	currently	currently	ADV	RB	_	_	_	_	_
17	under	under	ADP	IN	_	_	_	_	_
18	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 7996
# text = Document 0030011284 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011284	0030011284	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 7997
# text = Triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) induces nuclear translocation of NF-kappa B (p50/p65) in human monocytes and enhances viral replication in HIV-infected monocytic cells.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
4	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
5	CR1	CR1	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	CD35	CD35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CR3	CR3	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CD11b/CD18	CD11b/CD18	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
25	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
32	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
33	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
36	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 7998
# text = Monocyte/macrophages may harbor
1	Monocyte	Monocyte	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	harbor	harbor	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 7999
# text = HIV in a nonproductive fashion for prolonged periods of time.
1	HIV	haHive	VERB	VB	Abbr=Yes|VerbForm=Inf	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	nonproductive	nonproductive	ADJ	JJ	Degree=Pos	_	_	_	_
5	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	periods	period	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8000
# text = Viral gene expression may be reactivated by stimulation of the cells with LPS or cytokines such as TNF-alpha in vitro.
1	Viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	reactivated	reactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8001
# text = The effect of LPS and TNF-alpha is mediated by their ability to induce nuclear translocation of the DNA-binding heterodimer NF-kappa B (p50/p65), which binds to a specific sequence in the HIV-long terminal repeat.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
24	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
31	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
45	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
46	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8002
# text = The present study demonstrates that triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) enhances viral replication in HIV-infected human monocytic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	CR1	CR1	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CD35	CD35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CR3	CR3	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CD11b/CD	Cd11b/cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
21	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8003
# text = Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti-CR1 or anti-CR3
1	Monocytic	Monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
7	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
8	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	F	F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	ab	ab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
34	anti-CR1	anti-cr1	NOUN	NN	Number=Sing	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	anti-CR3	anti-CR3	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8004
# text = Abs or with C3 fragments.
1	Abs	Abs	PROPN	NNP	Number=Sing	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	C3	C3	NOUN	NN	Number=Sing	_	_	_	_
5	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8005
# text = Stimulation of CR1 or CR3 induces a two- to fourfold increase in the amount of cell-associated and released p24
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CR1	CR1	NUM	CD	NumType=Card	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	CR3	CR3	NUM	CD	NumType=Card	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	fourfold	fourfold	VERB	VB	VerbForm=Inf	_	_	_	_
12	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	p24	p24	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8006
# text = Ag in cell cultures that was equivalent to that observed in control cultures triggered with LPS.
1	Ag	ag	VERB	VBG	VerbForm=Ger	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
14	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8007
# text = We further observed that stimulation of CR1 or CR3 induces the nuclear translocation of NF-kappa B p50/p65 in infected cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CR1	CR1	NUM	CD	NumType=Card	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	CR3	CR3	NUM	CD	NumType=Card	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8008
# text = Translocation of NF-kappa B p50/p65 was also observed following stimulation of CR1 or CR3 of uninfected peripheral blood monocytes from HIV-seronegative donors.
1	Translocation	Translocation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	NOUN	NN	Number=Sing	_	_	_	_
7	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CR1	CR1	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	CR3	CR3	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	uninfected	uninfect	ADJ	JJ	Degree=Pos	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	seronegative	seronegative	ADJ	JJ	Degree=Pos	_	_	_	_
27	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8009
# text = The amount of protein translocated was similar to that observed when cells were stimulated with rhTNF-alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	translocated	translocate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	when	when	ADV	WRB	PronType=Int	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	rhTNF	rhTNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8010
# text = TNF-alpha did not mediate the translocation of NF-kappa B p50/p65 induced by triggering of complement receptors.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	complement	complement	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8011
# text = Taken together, these observations suggest that HIV gene expression may be activated in infected monocytes through interaction of the cells with complement-opsonized particles and that enhanced viral replication is associated with C3 receptor-mediated nuclear translocation of the NF-kappa B complex.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	complement	complement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	opsonized	opsonize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	particles	particle	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
31	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	C3	C3	NUM	CD	NumType=Card	_	_	_	_
36	receptor-	receptor-	PUNCT	:	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8012
# text = Document 0030011288 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011288	0030011288	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8013
# text = The carboxyl-terminal cytoplasmic domain of CD36 is required for oxidized low-density lipoprotein modulation of NF-kappaB activity by tumor necrosis factor-alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD36	CD36	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	density	density	NOUN	NN	Number=Sing	_	_	_	_
16	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
17	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8014
# text = The binding of oxidized low-density lipoprotein (Ox LDL) by monocyte-macrophages causes pleiotropic effects, including changes in gene expression, and is thought to represent an early event in atherogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	oxidized	oxidize	ADJ	JJ	Degree=Pos	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	density	density	NOUN	NN	Number=Sing	_	_	_	_
8	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
11	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	macrophages	macrophage	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
18	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
19	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
34	event	event	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8015
# text = The integral membrane glycoprotein CD36 appears to play a physiological role in binding and uptake of Ox LDL by monocyte-macrophages, although the molecular events associated with CD36-Ox LDL interaction are unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	integral	integral	ADJ	JJ	Degree=Pos	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
5	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	36	36	NUM	CD	NumType=Card	_	_	_	_
7	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
19	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	although	although	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
27	events	event	NOUN	NNS	Number=Plur	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
33	LDL	Ldl	PROPN	NNP	Number=Sing	_	_	_	_
34	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8016
# text = To approach this issue, we used CD36 transfected Chinese hampster ovary (CHO) cells, exposed them to Ox LDL, and determined changes in the activity of the transcription factor NF-kappaB.
1	To	to	PART	TO	_	_	_	_	_
2	approach	approach	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	issue	issue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	36	36	NUM	CD	NumType=Card	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
12	hampster	hampster	NOUN	NN	Number=Sing	_	_	_	_
13	ovary	ovary	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CHO	cho	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
23	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8017
# text = We report here that Ox LDL enhanced DNA binding activity of nuclear extracts to an NF-kappaB sequence following activation of CD36-producing CHO cells with the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
6	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	_
7	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	CD36	CD36	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-producing	-produce	VERB	VBG	VerbForm=Ger	_	_	_	_
25	CHO	Chough	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
31	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
32	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8018
# text = This enhanced DNA binding activity was inhibited by coincubation of CD36 transfected cells with the human CD36-specific antibody OKM5.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	coincubation	coincubation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD36	CD36	NUM	CD	NumType=Card	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
20	OKM5	Okm5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8019
# text = We also determined that activation of NF-kappaB
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 8020
# text = DNA binding activity required an intact carboxyl-terminal cytoplasmic segment on CD36.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
7	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
11	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8021
# text = Our results support the idea that human CD36 mediates signal transduction events in response to Ox LDL.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	idea	idea	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	_
9	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	events	event	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	Ox	Ox	PROPN	NNP	Number=Sing	_	_	_	_
17	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8022
# text = Document 0030011290 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011290	0030011290	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8023
# text = One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	base	base	NOUN	NN	Number=Sing	_	_	_	_
3	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
4	change	change	NOUN	NN	Number=Sing	_	_	_	_
5	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	kB	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-enhancer	-enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8024
# text = The inducible, T cell-specific enhancers of murine and human Interleukin 2 (Il-2) genes contain the kB-like sequence GGGATTTCACC as an essential cis-acting enhancer motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	Il	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	GGGATTTCACC	Gggatttcacc	NOUN	NN	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
31	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
34	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
35	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8025
# text = When cloned in multiple copies this so-called TCEd (distal T cell element) acts as an inducible proto-enhancer element in E14
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
6	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	E14	E14	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 8026
# text = T lymphoma cells, but not in HeLa cells.
1	T	t	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	not	not	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8027
# text = In extracts of induced, Il-2 secreting El4 cells three individual protein factors bind to TCEd DNA.
1	In	in	ADP	IN	_	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Il	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	secreting	secreting	NOUN	NN	Number=Sing	_	_	_	_
10	El4	El4	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	three	three	NUM	CD	NumType=Card	_	_	_	_
13	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	TCEd	TCEd	VERB	VB	VerbForm=Inf	_	_	_	_
19	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8028
# text = The binding of the most prominent factor, named TCF-1 (T cell factor
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	most	most	ADV	RBS	_	_	_	_	_
6	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	named	name	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	T	t	NUM	CD	NumType=Card	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8029
# text = 1), is correlated with the proto-enhancer activity of TCEd.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-enhancer	-enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8030
# text = TCF-1 consists of two polypeptides of about 50 kD and 105 kD; the former seems to be related to the 50 kD polypeptide of NF-kB.
1	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	about	about	ADP	IN	_	_	_	_	_
10	50	50	NUM	CD	NumType=Card	_	_	_	_
11	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	105	105	NUM	CD	NumType=Card	_	_	_	_
14	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	former	former	ADJ	JJ	Degree=Pos	_	_	_	_
18	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	50	50	NUM	CD	NumType=Card	_	_	_	_
25	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
26	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8031
# text = Purified NF-kB is also able to bind to the TCEd, but TCF-1 binds stronger than NF-kB to TCEd DNA.
1	Purified	Purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
19	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	TCEd	TCEd	VERB	VB	VerbForm=Inf	_	_	_	_
26	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8032
# text = The conversion of the TCEd to a 'perfect' NF-kB binding site leads to a tighter binding of NF-kB to TCEd DNA and, as a functional consequence, to the activity of the 'converted' TCEd motifs in HeLa cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	conversion	conversion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
9	perfect	perfect	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	'	'	PUNCT	''	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	tighter	tighter	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	_
27	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
33	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
41	converted	converted	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	'	'	PUNCT	''	_	_	_	_	_
43	TCEd	Tce	NOUN	NN	Number=Sing	_	_	_	_
44	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8033
# text = Thus, the substitution of the underlined A residue to a C within the GGGATTTCACC motif abolishes its T cell-restricted activity and leads to its functioning in both El4 cells and HeLa cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	underlined	underlin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	C	C	PROPN	NNP	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GGGATTTCACC	GGGATTTCACC	PROPN	NNP	Number=Sing	_	_	_	_
16	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
17	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	functioning	functioning	VERB	VBG	VerbForm=Ger	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	El4	El4	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8034
# text = These results indicate that lymphocyte-specific factors binding to the TCEd are involved in the control of T cell specific-transcription of the Il-2 gene.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TCEd	tced	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	control	control	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Il	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8035
# text = Document 0030011296 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011296	0030011296	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8036
# text = IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
14	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
16	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8037
# text = Activation of the CD28 surface receptor provides a major costimulatory signal for T cell activation resulting in enhanced production of interleukin-2 (IL-2) and cell proliferation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8038
# text = In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates (ROIs) which are required for CD28-mediated activation of the NF-kappa B/CD28-responsive complex and IL-2 expression.
1	In	in	ADP	IN	_	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
9	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
10	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
14	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
19	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ROIs	ROI	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B/CD28	B/CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-responsive	-responsive	ADJ	JJ	Degree=Pos	_	_	_	_
38	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8039
# text = Delineation of the CD28 signaling cascade was found to involve protein tyrosine kinase activity, followed by the activation of phospholipase A2 and 5-lipoxygenase.
1	Delineation	Delineation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
22	A2	A2	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8040
# text = Our data suggest that lipoxygenase metabolites activate ROI formation which then induce IL-2 expression via NF-kappa B activation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
6	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
7	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	ROI	Roi	NUM	CD	NumType=Card	_	_	_	_
9	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	then	then	ADV	RB	PronType=Dem	_	_	_	_
12	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8041
# text = These findings should be useful for therapeutic strategies and the development of immunosuppressants targeting the CD28 costimulatory pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
8	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	development	development	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
14	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
17	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8042
# text = Document 0030011298 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011298	0030011298	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8043
# text = CD2 signalling induces phosphorylation of CREB in primary lymphocytes.
1	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
2	signalling	signalling	VERB	VBG	VerbForm=Ger	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8044
# text = Promoter sequences responsive to cyclic AMP (cAMP) are found in a number of cellular genes, and bind transcription factors of the cAMP response element binding protein (CREB)/activating transcription factor-1 (ATF-1) family.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
3	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
6	AMP	Amp	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	element	element	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-1	-1	NUM	CD	NumType=Card	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	ATF	Atf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8045
# text = We have used a human T-lymphotropic virus type 1 (HTLV-1) model of cAMP response element (CRE) transcription to investigate the influence of lymphocyte activation on transcription from homologous regions in the viral promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	model	model	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CRE	CRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
36	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8046
# text = We previously demonstrated increased HTLV-1 transcription following CD2 but not CD3 receptor cross-linking.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
10	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8047
# text = We hypothesized that this increased viral transcription was mediated, in part, through the phosphorylation of CREB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8048
# text = Therefore, we investigated CD2 and CD3 receptor-mediated signalling in primary human peripheral blood mononuclear cells (PBMC).
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8049
# text = CD2, but not CD3, cross-linking increased cAMP detected by competitive enzyme-linked immunosorbent assay (ELISA) approximately fourfold.
1	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	but	but	CCONJ	CC	_	_	_	_	_
4	not	not	ADV	RB	_	_	_	_	_
5	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	cross	cross	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
8	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	immunosorbent	immunosorbent	ADJ	JJ	Degree=Pos	_	_	_	_
18	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	approximately	approximately	ADV	RB	_	_	_	_	_
23	fourfold	fourfold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8050
# text = CD2 cross-linking concurrently increased phosphorylation of CREB detected by immunoblot assay eightfold.
1	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	concurrently	concurrently	ADV	RB	_	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
13	eightfold	eightfold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8051
# text = Consistent with post-translational regulation, no change in total level of CREB protein was observed.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	post	post	X	AFX	_	_	_	_	SpaceAfter=No
4	-translational	-translational	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	change	change	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8052
# text = Phosphorylation of CREB occurred through a herbimycin A and Rp-cAMP- sensitive pathway, suggesting phosphorylation required antecedent activation of both protein tyrosine kinases (PTK) and protein kinase A (PKA).
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
4	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Rp-cAMP	Rp-camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	antecedent	antecedent	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	A	A	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8053
# text = Both CD2 and CD3 cross-linking increased binding of nuclear proteins to a radiolabelled CRE oligonucleotide probe in electrophoretic mobility shift assays suggesting that lymphocyte activation enhances binding independently of phosphorylation of CREB at serine 133.
1	Both	both	DET	DT	_	_	_	_	_
2	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
5	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	radiolabelled	radiolabell	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
16	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
17	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	independently	independently	ADV	RB	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
36	133	133	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8054
# text = These data indicate specific modulation of the CREB/ATF-1 family of transcription factors by the CD2 signalling pathway and suggest CD2 receptor modulation of CRE-mediated transcription following ligand engagement (e.g. cell-to-cell contact).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
20	signalling	signalling	VERB	VBG	VerbForm=Ger	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
24	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
33	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
34	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	e.g.	e.g.	X	FW	_	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	contact	contact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8055
# text = Document 0030011301 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011301	0030011301	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8056
# text = Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
16	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8057
# text = Human immunodeficiency virus type-1 (HIV-1) transcription is dependent on the interaction of host-cell transcription factors with cis-regulatory DNA elements within the viral long terminal repeat (LTR).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	within	within	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
32	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
33	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
34	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8058
# text = Much attention has focused on the series of sequence elements upstream of the transcriptional initiation site in the U3 region of the LTR including the Sp1 and NF-kappaB binding sites.
1	Much	much	ADJ	JJ	Degree=Pos	_	_	_	_
2	attention	attention	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	series	series	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
11	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	U3	U3	NOUN	NN	Number=Sing	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8059
# text = Recent studies, however, demonstrate that the transcribed 5'-untranslated leader region (5'-UTR) also contains important transcriptional elements.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcribed	transcribe	NOUN	NN	Number=Sing	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
12	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
13	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
18	UTR	Utr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8060
# text = These regulatory elements situated downstream of transcription interact with constitutive and inducible transcription factors, mediate transmission of cellular activation signals, and are important for efficient HIV-1 transcription and replication.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	situated	situate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
17	transmission	transmission	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8061
# text = The 5'-UTR contains binding sites for the transcription factors AP-1, NF-kappaB, NF-AT, IRF, and Sp1. Mutations in these binding sites can interfere with the viral response to cell activation signals, decrease LTR transcription, and inhibit viral replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	UTR	UTR	PROPN	NNP	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_
30	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
36	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
47	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
48	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
53	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8062
# text = The 5'-UTR also interacts with a specific nucleosome that is rapidly displaced during transcriptional activation of the latent provirus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	UTR	UTR	PROPN	NNP	Number=Sing	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	nucleosome	nucleosome	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	rapidly	rapidly	ADV	RB	_	_	_	_	_
15	displaced	displace	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
22	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8063
# text = We propose that the inducible transcription factor binding sites in the 5'-UTR comprise a downstream enhancer domain that can function independent of, or in concert with, the LTR promoter to rapidly increase latent proviral transcription in response to cell activation signals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	UTR	UTR	ADV	RB	_	_	_	_	_
16	comprise	comprise	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	LTR	LTR	ADJ	JJ	Degree=Pos	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	rapidly	rapidly	ADV	RB	_	_	_	_	_
37	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
38	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
39	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	response	response	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8064
# text = In this review, we describe the host-cell transcription factors that interact with the 5'-UTR and discuss their role in the transcriptional regulation of HIV-1 gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	'	's	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	UTR	UTR	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	role	role	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8065
# text = Document 0030011303 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011303	0030011303	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8066
# text = Regulation of M-CSF expression by M-CSF: role of protein kinase C and transcription factor NF kappa B. Macrophage-colony-stimulating factor (M-CSF), also referred to as CSF-1, regulates the survival, growth, differentiation and functional activity of monocytes by binding to a single class of high-affinity cell surface receptors, known to be the product of the c-fms protooncogene.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
23	Macrophage	Macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	also	also	ADV	RB	_	_	_	_	_
36	referred	refer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
52	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
55	by	by	SCONJ	IN	_	_	_	_	_
56	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
57	to	to	ADP	IN	_	_	_	_	_
58	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
60	class	class	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
65	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
66	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
67	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
70	to	to	PART	TO	_	_	_	_	_
71	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
72	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
73	product	product	NOUN	NN	Number=Sing	_	_	_	_
74	of	of	ADP	IN	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
77	fms	fm	NOUN	NNS	Number=Plur	_	_	_	_
78	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8067
# text = The detection of both M-CSF and c-fms expression by cells of the monocyte lineage has suggested that M-CSF may act by an autocrine mechanism.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	fms	fm	NOUN	NNS	Number=Plur	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
16	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
28	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8068
# text = Interestingly, it has been shown that M-CSF can induce the expression of its own gene.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8069
# text = Although sensitivity to M-CSF can be modulated by regulation of receptor expression and function, M-CSF responsiveness is largely determined at a postreceptor level.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	M-	M-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
20	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	largely	largely	ADV	RB	_	_	_	_	_
23	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	postreceptor	postreceptor	ADJ	JJ	Degree=Pos	_	_	_	_
27	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8070
# text = To date, little is known about the intracellular pathway of M-CSF signal transduction.
1	To	to	ADP	IN	_	_	_	_	_
2	date	date	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	about	about	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8071
# text = We have therefore investigated the changes in protein kinase C (PKC) activity upon exposure of monocytes to M-CSF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	upon	upon	ADP	IN	_	_	_	_	_
16	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8072
# text = We show that M-CSF activates and translocates PKC.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
7	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	translocates	translocate	NOUN	NNS	Number=Plur	_	_	_	_
10	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8073
# text = Inhibition of PKC by the isoquinoline derivative H7 abolishes induction of M-CSF by M-CSF.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	isoquinoline	isoquinoline	NOUN	NN	Number=Sing	_	_	_	_
7	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
8	H7	H7	NUM	CD	NumType=Card	_	_	_	_
9	abolishes	abolish	NOUN	NNS	Number=Plur	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8074
# text = Furthermore, activation of PKC was pertussis-toxin-sensitive and was associated with the detection of an NF kappa B protein in nuclear extracts of M-CSF-induced blood monocytes but not in monocytes exposed to medium treatment only.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	pertussis-toxin	pertussis-toxin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
31	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	medium	medium	VERB	VB	VerbForm=Inf	_	_	_	_
39	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
40	only	only	ADV	RB	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8075
# text = The results suggest that M-CSF induction of M-CSF involves G proteins, PKC and NF kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
13	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
14	G	g	VERB	VBG	VerbForm=Ger	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8076
# text = Document 0030011305 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011305	0030011305	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8077
# text = T-cell expression of the human GATA-3 gene is regulated by a non-lineage-specific silencer.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	non-lineage	non-lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8078
# text = The GATA-3 transcription factor is required for development of the T-cell lineage and Th2 cytokine gene expression in CD4 T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	3	3	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
23	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8079
# text = We have mapped the DNase-I-hypersensitive (HS) regions of the human GATA-3 gene in T-cells and non-T-cells and studied their transcriptional activities.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HS	h	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	non-T-	non-t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8080
# text = HS I-III, located 5' from the transcriptional initiation site, were found in hematopoietic and non-hematopoietic cells, whereas HS IV-VII, located 3' from the transcriptional start site, were exclusively observed in T-cells.
1	HS	h	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	III	Iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	non-hematopoietic	non-hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
25	IV	IV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	VII	VII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	'	'	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	start	start	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	exclusively	exclusively	ADV	RB	_	_	_	_	_
40	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8081
# text = Among these hypersensitive sites, two transcriptional control elements were found, one in the first intron of the GATA-3 gene and the other between 8.3 and 5.9 kilobases 5' from the GATA-3 transcriptional initiation site.
1	Among	among	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
17	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
27	between	between	ADP	IN	_	_	_	_	_
28	8.3	8.3	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	5.9	5.9	NUM	CD	NumType=Card	_	_	_	_
31	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
32	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	'	'	NOUN	NNS	Number=Plur	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	3	3	NUM	CD	NumType=Card	_	_	_	_
39	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
40	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
41	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8082
# text = The first intron acted as a strong transcriptional activator in a position-dependent manner and with no cell-type specificity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
4	acted	act	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8083
# text = The upstream regulatory element could confer T-cell specificity to the GATA-3 promoter activity, and analysis of this region revealed a 707-base pair silencer that drastically inhibited GATA-3 promoter activity in non-T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
7	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	707	707	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-base	-base	NOUN	NN	Number=Sing	_	_	_	_
27	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
28	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	drastically	drastically	ADV	RB	_	_	_	_	_
31	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	3	3	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	non-T-	non-t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8084
# text = Two CAGGTG E-boxes, located at the 5'- and 3'-ends of the silencer, were necessary for this silencer activity.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	CAGGTG	Caggtg	ADJ	JJ	Degree=Pos	_	_	_	_
3	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	boxes	box	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	ends	end	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8085
# text = The 3'-CAGGTG E-box could bind USF proteins, the ubiquitous repressor ZEB, or the basic helix-loop-helix proteins E2A and HEB, and we showed that a competition between ZEB and E2A/HEB proteins is involved in the silencer activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	CAGGTG	CAGGTG	NOUN	NN	Number=Sing	_	_	_	_
6	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	USF	USF	ADP	RP	_	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
21	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	HEB	HEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
31	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
35	between	between	ADP	IN	_	_	_	_	_
36	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
40	HEB	Heb	PROPN	NNP	Number=Sing	_	_	_	_
41	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8086
# text = Document 0030011313 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011313	0030011313	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8087
# text = Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.
1	Negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8088
# text = IL-2 gene transcription is affected by several nuclear proteins.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8089
# text = We asked whether dexamethasone (Dex) and cyclosporin A (CsA) inhibit IL-2 gene transcription by interfering with the activity of nuclear proteins that bind to the IL-2 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	asked	ask	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	dexamethasone	dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Dex	Dex	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	cyclosporin	cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
10	A	a	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8090
# text = Nuclear extracts from primary human T lymphocytes were analyzed by electrophoretic DNA mobility shift assays.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
14	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
15	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8091
# text = Both Dex and CsA inhibited the binding of transcription factors AP-1 and NF-AT, but not of NF-kB and OCT-1/OAF, to their corresponding sites on the IL-2 gene promoter.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	Dex	Dex	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	OCT	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	OAF	Oaf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	on	on	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8092
# text = To correlate changes in nuclear factor binding in vitro with transcriptional activity in vivo and define the structural requirements for IL-2 promoter repression, we used transient DNA transfections.
1	To	to	ADP	IN	_	_	_	_	_
2	correlate	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
19	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
28	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	transfections	transfection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8093
# text = Jurkat cells were transfected with plasmids containing either the intact IL-2 promoter or its AP-1, NF-AT, and NF-kB motifs.
1	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
7	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	either	either	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
29	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8094
# text = Dex inhibited the IL-2 promoter and the AP-1, but not the NF-AT and NF-kB plasmids.
1	Dex	Dex	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
24	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8095
# text = In contrast, CsA inhibited the IL-2 promoter and the NF-AT, but not the AP-1 and NF-kB plasmids.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kB	kb	NOUN	NN	Number=Sing	_	_	_	_
27	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8096
# text = These results suggest that in human T lymphocytes both Dex and CsA inhibited IL-2 gene transcription through interference with transcription factors AP-1 and NF-AT.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	Dex	Dex	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
13	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8097
# text = We propose that, while maximum inhibition may involve interaction with both transcription factors, AP-1 is the primary target of Dex.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	while	while	SCONJ	IN	_	_	_	_	_
6	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
22	target	target	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Dex	Dex	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8098
# text = Document 0030011325 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011325	0030011325	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8099
# text = Analysis of the ligand-binding domain of human retinoic acid receptor alpha by site-directed mutagenesis.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
11	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8100
# text = Three subtypes of retinoic acid receptors (RAR), termed RAR alpha, RAR beta, and RAR gamma, have been described.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	subtypes	subtype	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	RAR	RAR	ADP	IN	_	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
16	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
20	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8101
# text = They are composed of different structural domains, including distinct domains for DNA and ligand binding.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
7	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8102
# text = RARs specifically bind all-trans-retinoic acid (RA), 9-cis-RA, and retinoid analogs.
1	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	_
2	specifically	specifically	ADV	RB	_	_	_	_	_
3	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	all	all	DET	DT	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
9	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	9-	9-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	analogs	analog	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8103
# text = In this study, we examined the functional role of cysteine and arginine residues in the ligand-binding domain of hRAR alpha (hRAR alpha-LBD, amino acids 154 to 462).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	arginine	arginine	NUM	CD	NumType=Card	_	_	_	_
14	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	hRAR	hRAR	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	hRAR	hRAR	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	LBD	lbd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	amino	amino	DET	DT	_	_	_	_	_
31	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
32	154	154	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	462	462	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8104
# text = All conserved cysteine and arginine residues in this domain were mutated by site-directed mutagenesis, and the mutant proteins were characterized by blocking reactions, ligand-binding experiments, transactivation assays, and protease mapping.
1	All	all	DET	DT	_	_	_	_	_
2	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
6	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	SCONJ	IN	_	_	_	_	_
25	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
26	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
34	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
38	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8105
# text = Changes of any cysteine residue of the hRAR alpha-LBD had no significant influence on the binding of all-trans RA or 9-cis RA.
1	Changes	change	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	any	any	DET	DT	_	_	_	_	_
4	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
5	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hRAR	hRAR	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	LBD	LBD	PROPN	NNP	Number=Sing	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
15	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	all	all	DET	DT	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
23	RA	RA	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
28	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8106
# text = Interestingly, residue C-235 is specifically important in antagonist binding.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	residue	residue	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	235	235	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	antagonist	antagonist	ADJ	JJ	Degree=Pos	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8107
# text = With respect to arginine residues, only the two single mutations of R-276 and R-394 to alanine showed a dramatic decrease of agonist and antagonist binding whereas the R272A mutation showed only a slight effect.
1	With	with	ADP	IN	_	_	_	_	_
2	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	arginine	arginine	VERB	VB	VerbForm=Inf	_	_	_	_
5	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
11	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	R-	R-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	276	276	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	R-	R-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	394	394	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	alanine	alanine	NUM	CD	NumType=Card	_	_	_	_
20	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
23	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	whereas	whereas	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	R272	R272	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
34	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	only	only	ADV	RB	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
38	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8108
# text = For all other arginine mutations, no differences in affinity were detectable.
1	For	for	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
5	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8109
# text = The two mutations R217A and R294A caused an increased binding efficiency for antagonists but no change in agonist binding.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
4	R217A	R217A	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	R294	R294	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	A	A	PROPN	NNP	Number=Sing	_	_	_	_
8	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	no	no	DET	DT	_	_	_	_	_
17	change	change	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
20	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8110
# text = From these results, we can conclude that electrostatic interactions of retinoids with the RAR alpha-LBD play a significant role in ligand binding.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	conclude	conclude	VERB	VB	VerbForm=Inf	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	electrostatic	electrostatic	ADJ	JJ	Degree=Pos	_	_	_	_
10	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	LBD	lbd	PROPN	NNP	Number=Sing	_	_	_	_
19	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8111
# text = In addition, antagonists show distinctly different requirements for efficient binding, which may contribute to their interference in the ligand-inducible transactivation function of RAR alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	distinctly	distinctly	ADV	RB	_	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Int	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8112
# text = Document 0030011326 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011326	0030011326	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8113
# text = Nuclear Rel-A and c-Rel protein complexes are differentially distributed within human thymocytes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	A	a	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	differentially	differentially	ADV	RB	_	_	_	_	_
13	distributed	distribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8114
# text = Nuclear factor-kappa B (NF-kappa B)/Rel proteins are inducible transcriptional regulators of numerous cellular genes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8115
# text = They are particularly abundant in lymphoid tissues and are thought to be critical for the transcription of genes involved in immune and inflammatory responses.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	particularly	particularly	ADV	RB	_	_	_	_	_
4	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8116
# text = We have reported previously that a nuclear NF-kappa B activity was present in freshly extracted human thymocytes in the absence of in vitro treatment of these cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	previously	previously	ADV	RB	_	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	freshly	freshly	ADV	RB	_	_	_	_	_
17	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8117
# text = In the present report, we identified NF-kappa B proteins extracted from human thymocyte nuclei as being p50/p65 and p50/c-Rel complexes.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	extracted	extract	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
17	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
20	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	p50/c	p50/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
27	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8118
# text = Immunochemical and immunofluorescent staining of thymus sections using specific
1	Immunochemical	Immunochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	immunofluorescent	immunofluorescent	ADJ	JJ	Degree=Pos	_	_	_	_
4	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
7	sections	section	NOUN	NNS	Number=Plur	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 8119
# text = Abs allowed visualization of nuclear NF-kappa B proteins in both thymocytes and nonthymocyte cells.
1	Abs	Abs	ADV	RB	_	_	_	_	_
2	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	visualization	visualization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	nonthymocyte	nonthymocyte	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8120
# text = This detection suggested a preferential activation of p50/c-Rel in medullary thymocytes, whereas p50/p65 was present in both cortical and medullary regions of human thymus lobules.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	preferential	preferential	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p50/c	p50/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	medullary	medullary	ADJ	JJ	Degree=Pos	_	_	_	_
13	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	cortical	cortical	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	medullary	medullary	ADJ	JJ	Degree=Pos	_	_	_	_
26	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
30	lobules	lobule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8121
# text = However, the intensity of p65 labeling was much higher in several thymocytes from the medulla.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p65	p65	NUM	CD	NumType=Card	_	_	_	_
7	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	much	much	ADV	RB	_	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	medulla.	medulla.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8122
# text = p65, p50, and c-Rel activities were found in both CD4- and CD8-positive thymocytes.
1	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CD8	Cd8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
20	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8123
# text = These observations suggest that p65 and c-Rel complexes play distinct roles in gene expression and that both forms of NF-kappa B play critical roles during late stages of the intrathymic maturation of T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
11	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
28	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
31	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	intrathymic	intrathymic	ADJ	JJ	Degree=Pos	_	_	_	_
35	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8124
# text = Document 0030011328 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011328	0030011328	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8125
# text = Abundant expression of erythroid transcription factor P45 NF-E2 mRNA in human peripheral granurocytes.
1	Abundant	Abundant	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	P45	P45	PROPN	NNP	Number=Sing	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	E2	E2	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	granurocytes	granurocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8126
# text = Transcription factor NF-E2 is crucial for regulation of erythroid-specific gene expression.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8127
# text = p45 subunit of NF-E2 contains a basic-leucine zipper domain and dimerizes with the small Maf family protein to form functional NF-E2 complex.
1	p45	p45	NUM	CD	NumType=Card	_	_	_	_
2	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	leucine	leucine	NOUN	NN	Number=Sing	_	_	_	_
12	zipper	zipper	NOUN	NN	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	dimerizes	dimerize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
19	Maf	Maf	NOUN	NN	Number=Sing	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
24	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8128
# text = While p45 expression was shown to be restricted to erythroid cells, megakaryocytes and mast cells in hematopoietic lineage, we found in this study that p45 mRNA is abundantly transcribed in the granulocyte fraction of human peripheral blood cells.
1	While	while	SCONJ	IN	_	_	_	_	_
2	p45	p45	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	erythroid	erythroid	VERB	VB	VerbForm=Inf	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	mast	mast	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	study	study	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	p45	p45	NUM	CD	NumType=Card	_	_	_	_
28	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	abundantly	abundantly	ADV	RB	_	_	_	_	_
31	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
35	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
39	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8129
# text = As neutrophils occupy approximately 92% of the cells in granulocyte fraction of human peripheral blood cells.
1	As	as	SCONJ	IN	_	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	occupy	occupy	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	%	%	SYM	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
12	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8130
# text = As neutrophils occupy approximately 92% of the cells in this fraction, the cells expressing p45 is most likely to be neutrophils.
1	As	as	SCONJ	IN	_	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	occupy	occupy	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	%	%	SYM	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
17	p45	p45	NUM	CD	NumType=Card	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	most	most	ADV	RBS	_	_	_	_	_
20	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8131
# text = p45 mRNA is also expressed in HL-60 promyelocytes, albeit the expression level is much lower than that of the granulocyte fraction.
1	p45	p45	NUM	CD	NumType=Card	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	60	60	NUM	CD	NumType=Card	_	_	_	_
10	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	albeit	albeit	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	much	much	ADV	RB	_	_	_	_	_
18	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
24	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8132
# text = HL-60 cells were found to express mafK mRNA, indicating the presence of genuine NF-E2 complex in the cells.
1	HL	Hl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	60	60	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
9	mafK	mafK	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	genuine	genuine	PROPN	NNP	Number=Sing	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	E2	e2	NUM	CD	NumType=Card	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8133
# text = Although p45 mRNA is transcribed from two different promoters, aNF-E2 promoter and fNF-E2 promoter, in erythroid and megakaryocytic lineage cells, p45 mRNA is transcribed only from aNF-E2 promoter.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	p45	p45	PROPN	NNP	Number=Sing	_	_	_	_
3	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	aNF	anf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	E2	e2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	fNF	fnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	E2	e2	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	p45	p45	NUM	CD	NumType=Card	_	_	_	_
29	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	only	only	ADV	RB	_	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	aNF	aNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	E2	E2	NUM	CD	NumType=Card	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8134
# text = The expression of p45 megakaryocytic lineage cells, p45 mRNA is transcribed only from aNF-E2 promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p45	p45	NUM	CD	NumType=Card	_	_	_	_
5	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p45	p45	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	aNF	aNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	E2	E2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8135
# text = The expression of p45 mRNA in the neutrophils declined rapidly after transfer of the cells to in vitro culture and G-CSF could not sustain the expression from the down-regulation, suggesting the E2 may also participate in the regulation of neutrophil-specific gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p45	p45	NUM	CD	NumType=Card	_	_	_	_
5	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
9	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
19	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
23	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	sustain	sustain	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
37	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
38	also	also	ADV	RB	_	_	_	_	_
39	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	neutrophil	neutrophil	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
45	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8136
# text = Document 0030011338 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011338	0030011338	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8137
# text = Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells.
1	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8138
# text = CD40 is a receptor that is critical for the survival, growth, differentiation, and isotype switching of B lymphocytes.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	isotype	isotype	ADJ	JJ	Degree=Pos	_	_	_	_
18	switching	switching	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8139
# text = Although CD40 lacks intrinsic tyrosine kinase activity, its ligation induces protein tyrosine phosphorylation, which is necessary for several CD40-mediated events.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
3	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
10	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
12	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
13	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8140
# text = We show that engagement of CD40 induces tyrosine phosphorylation and activation of Jak3 as well as of STAT3.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8141
# text = Jak3 is constitutively associated with CD40, and this interaction requires a proline-rich sequence in the membrane-proximal region of CD40.
1	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	constitutively	constitutively	ADV	RB	_	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	proline	proline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8142
# text = Deletion of this sequence abolishes the capacity of CD40 to induce expression of CD23, ICAM-1, and lymphotoxin-alpha genes in B cells.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8143
# text = These results indicate that signaling through Jak3 is activated by CD40 and plays an important role in CD40-mediated functions.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8144
# text = Document 0030011339 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011339	0030011339	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8145
# text = Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7.
1	Thymocyte	Thymocyte	X	ADD	_	_	_	_	SpaceAfter=No
2	-thymic	-thymic	ADJ	JJ	Degree=Pos	_	_	_	_
3	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	level	level	NOUN	NN	Number=Sing	_	_	_	_
11	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	exclusively	exclusively	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
19	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	CD8	CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	(-)	(-)	PUNCT	.	_	_	_	_	_
25	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	+)	+)	PUNCT	-RRB-	_	_	_	_	_
28	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
35	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8146
# text = This work aims at identifying the thymocyte subpopulation able to support human immunodeficiency virus (HIV) replication under the biological stimuli of the thymic microenvironment.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	aims	aim	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	at	at	SCONJ	IN	_	_	_	_	_
5	identifying	identify	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
8	subpopulation	subpopulation	NOUN	NN	Number=Sing	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	support	support	VERB	VB	VerbForm=Inf	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
19	under	under	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
22	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
26	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8147
# text = In this report we demonstrate that interaction with thymic epithelial cells (TEC) induces a high-level replication of the T-tropic primary isolate HIV-1(B-LAIp) exclusively in the mature CD4(+) CD8(-) CD3(+) thymocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
10	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TEC	Tec	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	tropic	tropic	ADJ	JJ	Degree=Pos	_	_	_	_
25	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
26	isolate	isolate	NOUN	NN	Number=Sing	_	_	_	_
27	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	LAIp	LAIp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	exclusively	exclusively	ADV	RB	_	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
39	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	CD8	CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	(-)	(-)	PUNCT	.	_	_	_	_	_
45	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	(+)	(+)	PUNCT	-RRB-	_	_	_	_	_
47	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8148
# text = Tumor necrosis factor (TNF) and interleukin-7 (IL-7), secreted during this interaction, are critical cytokines for HIV long terminal repeat transactivation through NF-kappaB-dependent activation.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	7	7	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	secreted	secret	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
24	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
31	through	through	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8149
# text = TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor.
1	TNF	TNF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	particularly	particularly	ADV	RB	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	7	7	NUM	CD	NumType=Card	_	_	_	_
23	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	SCONJ	IN	_	_	_	_	_
28	sustaining	sustain	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	p75	p75	NOUN	NN	Number=Sing	_	_	_	_
34	TNF	TNF	ADP	IN	_	_	_	_	_
35	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8150
# text = The requirement for TNF is further confirmed by the observation that the inability of the intermediate CD4(+) CD8(-) CD3(-) thymocytes to replicate the virus is associated with a defect in TNF production during their interaction with TEC and correlates with the absence of nuclear NF-kappaB activity in these freshly isolated thymocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	further	further	ADV	RB	_	_	_	_	_
7	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	(-)	(-)	PUNCT	.	_	_	_	_	_
23	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	(-)	(-)	PUNCT	.	_	_	_	_	_
25	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
37	production	production	NOUN	NN	Number=Sing	_	_	_	_
38	during	during	ADP	IN	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	TEC	TEC	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
50	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
53	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
56	freshly	freshly	ADV	RB	_	_	_	_	_
57	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8151
# text = Addition of exogenous TNF to the intermediate thymocyte cultures induces NF-kappaB activity and is sufficient to promote HIV replication in the cocultures with TEC.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
8	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
9	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cocultures	coculture	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	TEC	Tec	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8152
# text = The other major subpopulation expressing the CD4 receptor, namely, the double-positive (DP) CD4(+) CD8(+) CD3(+/-) thymocytes, despite the entry of the virus, do not produce a significant level of virus, presumably because they are unresponsive to TNF and IL-7.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
4	subpopulation	subpopulation	NOUN	NN	Number=Sing	_	_	_	_
5	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	namely	namely	ADV	RB	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	DP	DP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	(+)	(+)	SYM	NFP	_	_	_	_	_
21	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	(+/-)	(+/-)	SYM	NFP	_	_	_	_	_
27	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	despite	despite	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
41	level	level	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	presumably	presumably	ADV	RB	_	_	_	_	_
46	because	because	SCONJ	IN	_	_	_	_	_
47	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
48	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
49	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8153
# text = Together, these data suggest that in vivo, despite an efficient entry of the virus in all the CD4(+) subpopulations, a high viral load may be generated exclusively within the mature CD4(+) CD8(-) CD3(+) subset of thymocytes.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	despite	despite	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	all	all	DET	PDT	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	subpopulations	subpopulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
28	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
29	load	load	NOUN	NN	Number=Sing	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
32	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	exclusively	exclusively	ADV	RB	_	_	_	_	_
34	within	within	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	mature	mature	NOUN	NN	Number=Sing	_	_	_	_
37	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	(-)	(-)	PUNCT	.	_	_	_	_	_
43	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	(+)	(+)	PUNCT	-RRB-	_	_	_	_	_
45	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8154
# text = However, under conditions of inflammatory response after infection, TNF might also be present in the intermediate thymocyte compartment, leading to efficient HIV replication in these cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	under	under	ADP	IN	_	_	_	_	_
4	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TNF	TNF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
19	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
20	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
26	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8155
# text = Document 0030011340 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011340	0030011340	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8156
# text = Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8157
# text = Stimulation of mature peripheral T cells by TCR engagement results in activation of signals that drive induction of cytokine gene expression and clonal expansion.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
9	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	drive	drive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
24	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8158
# text = However, under some conditions, engagement of the TCR leads instead to apoptosis.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	under	under	ADP	IN	_	_	_	_	_
4	some	some	DET	DT	_	_	_	_	_
5	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
11	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	instead	instead	ADV	RB	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8159
# text = Recent studies demonstrate that TCR-stimulated apoptosis requires expression of CD95 ligand on activated T cells followed by an interaction between CD95 ligand and the CD95 receptor also expressed on this population.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	CD95	Cd95	NUM	CD	NumType=Card	_	_	_	_
24	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CD95	Cd95	PROPN	NNP	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	also	also	ADV	RB	_	_	_	_	_
30	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8160
# text = The experiments reported in this study were designed to address the signaling events triggered by TCR engagement that are important for regulating CD95 ligand gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	address	address	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	events	event	NOUN	NNS	Number=Plur	_	_	_	_
14	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
17	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	SCONJ	IN	_	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
24	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8161
# text = To approach this, we generated a luciferase reporter construct containing elements of the CD95 ligand promoter.
1	To	to	PART	TO	_	_	_	_	_
2	approach	approach	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	_
16	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8162
# text = Using a previously described mutant of the Jurkat T cell line, we show that proximal signaling events dependent on the presence of the CD45 tyrosine phosphatase are required for TCR-stimulated CD95 ligand expression.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
18	events	event	NOUN	NNS	Number=Plur	_	_	_	_
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	CD95	Cd95	NUM	CD	NumType=Card	_	_	_	_
35	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8163
# text = Transient transfection studies demonstrate further that TCR-stimulated activation of the Ras signaling pathway is required for optimal activation of CD95 ligand.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	further	further	SCONJ	IN	_	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8164
# text = Next, in an effort to determine critical transcription factors that regulate CD95 ligand expression, we demonstrate a cyclosporin A-sensitive nuclear factor-AT response element in the promoter region of this gene that is critical for optimal CD95 ligand reporter activity in stimulated T cells.
1	Next	next	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	effort	effort	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	at	NOUN	NN	Number=Sing	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	that	that	PRON	WDT	PronType=Rel	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
42	CD95	Cd95	NUM	CD	NumType=Card	_	_	_	_
43	ligand	ligand	NUM	CD	NumType=Card	_	_	_	_
44	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
45	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	T	t	PROPN	NNP	Number=Sing	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8165
# text = Together, these studies begin a dissection of the biochemical events that lead to expression of CD95 ligand, a required step for TCR-induced apoptosis.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	begin	begin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
11	events	event	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CD95	CD95	NUM	CD	NumType=Card	_	_	_	_
18	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	step	step	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8166
# text = Document 0030011342 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011342	0030011342	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8167
# text = Involvement of Egr-1/RelA synergy in distinguishing T cell activation from tumor necrosis factor-alpha-induced NF-kappa B1 transcription.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
7	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	distinguishing	distinguishing	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	factor-alpha-induced	factor-alpha-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8168
# text = NF-kappa B is an important transcription factor required for T cell proliferation and other immunological functions.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
18	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8169
# text = The NF-kappa B1 gene encodes a 105-kD protein that is the precursor of the p50 component of NF-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
20	component	component	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8170
# text = Previously, we and others have demonstrated that NF-kappa B regulates the NF-kappa B1 gene.
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	others	other	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
19	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8171
# text = In this manuscript we have investigated the molecular mechanisms by which T cell lines stimulated with phorbol 12-myristate 13-acetate (PMA) and phytohemagglutin (PHA) display significantly higher levels of NF-kappa B1 encoding transcripts than cells stimulated with tumor necrosis factor-alpha, despite the fact that both stimuli activate NF-kappa B. Characterization of the NF-kappa B1 promoter identified an Egr-1 site which was found to be essential for both the PMA/PHA-mediated induction as well as the synergistic activation observed after the expression of the RelA subunit of NF-kappa B and Egr-1.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	manuscript	manuscript	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
21	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	phytohemagglutin	phytohemagglutin	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	display	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	significantly	significantly	ADV	RB	_	_	_	_	_
34	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
35	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B1	b1	NOUN	NN	Number=Sing	_	_	_	_
41	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
42	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
43	than	than	ADP	IN	_	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
48	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
49	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	despite	despite	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
56	that	that	SCONJ	IN	_	_	_	_	_
57	both	both	DET	DT	_	_	_	_	_
58	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
59	activate	activate	NOUN	NN	Number=Sing	_	_	_	_
60	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
63	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
64	Characterization	Characterization	PROPN	NNP	Number=Sing	_	_	_	_
65	of	of	ADP	IN	_	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
70	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
71	promoter	promoter	ADV	RB	_	_	_	_	_
72	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
73	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
74	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	-1	-1	NUM	CD	NumType=Card	_	_	_	_
76	site	site	NOUN	NN	Number=Sing	_	_	_	_
77	which	which	PRON	WDT	PronType=Rel	_	_	_	_
78	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
79	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
80	to	to	PART	TO	_	_	_	_	_
81	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
82	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
83	for	for	ADP	IN	_	_	_	_	_
84	both	both	CCONJ	CC	_	_	_	_	_
85	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
86	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
87	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
88	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
89	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
90	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
91	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
92	as	as	ADV	RB	_	_	_	_	_
93	well	well	ADV	RB	Degree=Pos	_	_	_	_
94	as	as	ADP	IN	_	_	_	_	_
95	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
96	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
97	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
98	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
99	after	after	ADP	IN	_	_	_	_	_
100	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
101	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
102	of	of	ADP	IN	_	_	_	_	_
103	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
104	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
105	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
106	of	of	ADP	IN	_	_	_	_	_
107	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
108	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
109	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
110	B	b	PROPN	NNP	Number=Sing	_	_	_	_
111	and	and	CCONJ	CC	_	_	_	_	_
112	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
113	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
114	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8172
# text = Furthermore, Egr-1 induction was required for endogenous NF-kappa B1 gene expression, since PMA/PHA-stimulated T cell lines expressing antisense Egr-1 RNA were inhibited in their ability to upregulate NF-kappa B1 transcription.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	since	since	ADP	IN	_	_	_	_	_
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
26	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
27	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
28	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-1	-1	NUM	CD	NumType=Card	_	_	_	_
30	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
35	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	upregulate	upregulate	VERB	VB	VerbForm=Inf	_	_	_	_
38	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
41	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
42	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8173
# text = Our studies indicate that transcriptional synergy mediated by activation of both Egr-1 and NF-kappa B may have important ramifications in T cell development by upregulating NF-kappa B1 gene expression.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
21	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
22	ramifications	ramification	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	SCONJ	IN	_	_	_	_	_
28	upregulating	upregulat	VERB	VBG	VerbForm=Ger	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8174
# text = Document 0030011345 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011345	0030011345	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8175
# text = Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	import	import	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	noninvasive	noninvasive	ADJ	JJ	Degree=Pos	_	_	_	_
23	delivery	delivery	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
26	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8176
# text = Activation of T lymphocytes by Ags or cytokines results in translocation of the transcription factors NF-kappa B, AP-1, NFAT, and STAT from the cytoplasm into the nucleus.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	Ags	ag	NOUN	NNS	Number=Plur	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
32	into	into	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8177
# text = The first step in the nuclear import process is recognition of a nuclear localization sequence (NLS) within the karyophilic protein by a cytoplasmic receptor such as the importin (karyopherin)-alpha subunit.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	step	step	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	import	import	NOUN	NN	Number=Sing	_	_	_	_
8	process	process	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NLS	NLS	INTJ	UH	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	karyophilic	karyophilic	ADJ	JJ	Degree=Pos	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	importin	importin	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	karyopherin	karyopherin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8178
# text = The NLSs of NF-kappa B, AP-1, and NFAT differ and the NLS of STAT1 has not yet been identified.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NLSs	NLSs	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
15	differ	differ	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NLS	nls	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	_
21	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	yet	yet	ADV	RB	_	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8179
# text = Herein we demonstrate that the inducible nuclear import of NF-kappa B, AP-1, NFAT, and STAT1 in Jurkat T lymphocytes is significantly inhibited by a cell-permeable peptide carrying the NLS of the NF-kappa B p50 subunit.
1	Herein	herein	ADV	WRB	PronType=Rel	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	import	import	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	NFAT	NFAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	significantly	significantly	ADV	RB	_	_	_	_	_
29	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	permeable	permeable	ADJ	JJ	Degree=Pos	_	_	_	_
35	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
36	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	NLS	nls	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	p50	p50	NUM	CD	NumType=Card	_	_	_	_
46	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8180
# text = NLS peptide-mediated disruption of the nuclear import of these transcription factors results in inhibition of I kappa B alpha and IL-2 gene expression, processes dependent on NF-kappa B or the combination of NF-kappa B, AP-1, and NFAT.
1	NLS	NLS	INTJ	UH	_	_	_	_	_
2	peptide	peptide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	import	import	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8181
# text = Further, we show that inhibitory NLS peptide interacts in vitro with a cytoplasmic NLS receptor complex comprised of the Rch1/importin (karyopherin)-beta heterodimer expressed in Jurkat T cells.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
7	NLS	Nl	NOUN	NN	Number=Sing	_	_	_	_
8	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
9	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	NLS	nls	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	comprised	comprise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Rch1	rch1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	importin	importin	ADJ	JJ	Degree=Pos	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	karyopherin	karyopherin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
30	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
33	T	T	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8182
# text = Taken together, these data indicate that the inducible nuclear import of NF-kappa B, AP-1, NFAT, and STAT1 in Jurkat T cells can be regulated by NLS peptide delivered noninvasively to the cytoplasm of Jurkat T cells to target members of the importin (karyopherin)-alpha beta NLS receptor complex.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	import	import	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
31	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
32	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	NLS	NLS	PROPN	NNP	Number=Sing	_	_	_	_
35	peptide	peptide	ADV	RB	_	_	_	_	_
36	delivered	deliver	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	noninvasively	noninvasively	ADV	RB	_	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
47	members	member	NOUN	NNS	Number=Plur	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	importin	importin	NOUN	NN	Number=Sing	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	karyopherin	karyopherin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
54	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
55	alpha	alpha	X	GW	_	_	_	_	_
56	beta	beta	X	GW	_	_	_	_	_
57	NLS	nls	X	GW	_	_	_	_	_
58	receptor	receptor	X	GW	_	_	_	_	_
59	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8183
# text = Document 0030011346 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011346	0030011346	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8184
# text = Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	differentially	differentially	ADV	RB	_	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
11	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
17	Th2	Th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8185
# text = Interleukin-5 (IL-5), which is produced by CD4(+)
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	(+)	(+)	SYM	NFP	_	_	_	_	_

# sent_id = 8186
# text = T helper 2 (Th2) cells, but not by Th1 cells, plays a key role in the development of eosinophilia in asthma.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	Th2	Th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	development	development	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	eosinophilia	eosinophilion	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8187
# text = Despite increasing evidence that the outcome of many diseases is determined by the ratio of the two subsets of CD4(+)
1	Despite	despite	SCONJ	IN	_	_	_	_	_
2	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	outcome	outcome	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
9	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	+)	+)	SYM	NFP	_	_	_	_	_

# sent_id = 8188
# text = T helper cells, Th1 and Th2, the molecular basis for Th1- and Th2- specific gene expression remains to be elucidated.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Th2	Th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
11	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	Th1	Th1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Th2	th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8189
# text = We previously established a critical role for the transcription factor GATA-3 in IL-5 promoter activation in EL-4 cells, which express both Th1- and Th2-type cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	EL	El	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
28	both	both	CCONJ	CC	_	_	_	_	_
29	Th1	th1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Th2	th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	type	type	NOUN	NN	Number=Sing	_	_	_	_
35	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8190
# text = Our studies reported here demonstrate that GATA-3 is critical for expression of the IL-5 gene in bona fide Th2 cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	bona	bona	NOUN	NN	Number=Sing	_	_	_	_
22	fide	fide	NOUN	NN	Number=Sing	_	_	_	_
23	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8191
# text = Whereas mutations in the GATA-3 site abolished antigen- or cAMP- stimulated IL-5 promoter activation in Th2 cells, ectopic expression of GATA-3 in Th1 cells or in a non-lymphoid, non-IL-5-producing cell line activated the IL-5 promoter.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	_
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	non-lymphoid	non-lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	non	non	X	AFX	_	_	_	_	SpaceAfter=No
40	-IL	-il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	line	line	NOUN	NN	Number=Sing	_	_	_	_
47	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	5	5	NUM	CD	NumType=Card	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8192
# text = During the differentiation of naive CD4(+)
1	During	during	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
6	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	(+)	(+)	SYM	NFP	_	_	_	_	_

# sent_id = 8193
# text = T cells isolated from T cell receptor transgenic mice, GATA-3 gene expression was up-regulated in developing
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	SCONJ	IN	_	_	_	_	_
21	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 8194
# text = Th2 cells, but was down-regulated in Th1 cells, and antigen- or cAMP-activated Th2 cells (but not Th1 cells) expressed the GATA-3 protein.
1	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	Th2	th2	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8195
# text = Thus, GATA-3 may play an important role in the balance between Th1 and Th2 subsets in immune responses.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
18	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	responses	respons	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8196
# text = Inhibition of GATA-3 activity has therapeutic potential in the treatment of asthma and other hypereosinophilic diseases.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
9	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	hypereosinophilic	hypereosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
18	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8197
# text = Document 0030011359 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011359	0030011359	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8198
# text = Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
14	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
17	-Tat	-Tat	ADJ	JJ	Degree=Pos	_	_	_	_
18	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
21	intrabodies	intrabody	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8199
# text = Human immunodeficiency virus type 1 (HIV-1)
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 8200
# text = Tat, an early regulatory protein that is critical for viral gene expression and replication, transactivates the HIV-1 long terminal repeat (LTR) via its binding to the transactivation response element (TAR) and, along with other cellular factors, increases viral transcription initiation and elongation.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	via	via	ADP	IN	_	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TAR	TAR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	along	along	ADP	IN	_	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
44	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
45	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
48	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
49	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
50	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	elongation	elongation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8201
# text = Tat also superactivates the HIV-1 promoter through a TAR-independent mechanism, including tumor necrosis factor alpha-induced and protein kinase C (PKC)-dependent activation of NF-kappa B, and inhibitors of Tat and NF-kappa B cooperatively down-regulate this Tat-mediated LTR superactivation.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	superactivates	superactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	TAR	Tar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha-induced	alpha-induced	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C	C	PROPN	NNP	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	cooperatively	cooperatively	ADV	RB	_	_	_	_	_
47	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
49	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
50	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
51	Tat-	Tat-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	LTR	Ltr	ADP	IN	_	_	_	_	_
54	superactivation	superactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8202
# text = In this study, a combined pharmacologic and genetic strategy using two PKC (NF-kappa B) inhibitors, pentoxifylline (PTX) and Go-6976, and a stably expressed anti-Tat single-chain intracellular antibody (sFv intrabody) was employed to obtain cooperative inhibition of both HIV-1 LTR-driven gene expression and HIV-1 replication.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	pharmacologic	pharmacologic	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
10	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	pentoxifylline	pentoxifylline	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	PTX	PTX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Go	go	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-6976	-6976	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	stably	stably	ADV	RB	_	_	_	_	_
33	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
35	-Tat	-Tat	ADJ	JJ	Degree=Pos	_	_	_	_
36	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
39	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
40	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	sFv	sFv	NOUN	NN	Number=Sing	_	_	_	_
43	intrabody	intrabody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
46	employed	employ	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	to	to	PART	TO	_	_	_	_	_
48	obtain	obtain	VERB	VB	VerbForm=Inf	_	_	_	_
49	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
50	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	both	both	DET	DT	_	_	_	_	_
53	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	_
56	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
60	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	1	1	NUM	CD	NumType=Card	_	_	_	_
65	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8203
# text = Treatment of cells with PTX and Go-6976 resulted in cooperative inhibition of both HIV-1 LTR-driven gene expression and HIV-1 replication.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	PTX	Ptx	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Go-6976	go-6976	PROPN	NNP	Number=Sing	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8204
# text = In addition, the combined use of anti-Tat sFv intrabodies and the two NF-kappa B inhibitors retained the virus in the latent state for as long as 45 days.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	use	use	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
9	-Tat	-Tat	PROPN	NNP	Number=Sing	_	_	_	_
10	sFv	sFv	PROPN	NNP	Number=Sing	_	_	_	_
11	intrabodies	intrabody	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
20	retained	retain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
26	state	state	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	as	as	ADV	RB	_	_	_	_	_
29	long	long	ADV	RB	Degree=Pos	_	_	_	_
30	as	as	SCONJ	IN	_	_	_	_	_
31	45	45	NUM	CD	NumType=Card	_	_	_	_
32	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8205
# text = The combined treatment resulted in more durable inhibition of HIV-1 replication than was seen with the NF-kappa B inhibitors alone or the anti-Tat sFv intrabodies alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
7	durable	durable	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
24	alone	alone	ADV	RB	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
28	-Tat	-Tat	ADJ	JJ	Degree=Pos	_	_	_	_
29	sFv	sFv	NOUN	NN	Number=Sing	_	_	_	_
30	intrabodies	intrabody	NOUN	NNS	Number=Plur	_	_	_	_
31	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8206
# text = Together, these results suggest that in future clinical gene therapy trials, a combined pharmacologic and genetic strategy like the one reported here may improve the survival of transduced cells and prolong clinical benefit.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	future	future	ADJ	JJ	Degree=Pos	_	_	_	_
9	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
12	trials	trial	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	pharmacologic	pharmacologic	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
19	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
20	like	like	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	one	one	NOUN	NN	Number=Sing	_	_	_	_
23	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	here	here	ADV	RB	PronType=Dem	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	improve	improve	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	prolong	prolong	ADJ	JJ	Degree=Pos	_	_	_	_
34	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
35	benefit	benefit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8207
# text = Document 0030011364 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011364	0030011364	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8208
# text = N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition.
1	N-acetyl	N-acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-L-	-L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
4	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	association	association	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8209
# text = N-acetyl-L-cysteine (NAC) is an antioxidant molecule endowed with immunomodulatory properties.
1	N-acetyl	N-acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-L-	-L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
11	endowed	endow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8210
# text = To investigate the effect of NAC on the induction phase of
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_

# sent_id = 8211
# text = T cell responses, we analyzed its action on human dendritic cells (DC) derived from adherent PBMC cultured with IL-4 and granulocyte-macrophage CSF.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	action	action	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
19	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
20	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
29	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8212
# text = We first found that NAC inhibited the constitutive as well as the LPS-induced activity of the transcription factor NF-kappaB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	first	first	ADV	RB	_	_	_	_	_
3	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
6	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADV	RB	_	_	_	_	_
10	well	well	ADV	RB	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8213
# text = In parallel, NAC was shown to down-regulate the production of cytokines by DC as well as their surface expression of HLA-DR, CD86 (B7-2), and CD40 molecules both at the basal state and upon LPS activation.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
17	as	as	ADV	RB	_	_	_	_	_
18	well	well	ADV	RB	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	DR	dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	CD86	Cd86	PROPN	NNP	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	B7	B7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
38	both	both	CCONJ	CC	_	_	_	_	_
39	at	at	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
42	state	state	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	upon	upon	ADP	IN	_	_	_	_	_
45	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8214
# text = NAC also inhibited DC responses induced by CD40 engagement.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
5	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
9	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8215
# text = The inhibitory effects of NAC were not due to nonspecific toxicity as neither the viability of DC nor their mannose receptor-mediated endocytosis were modified by NAC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	due	due	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
11	toxicity	toxicity	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	neither	neither	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	viability	viability	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
18	nor	nor	CCONJ	CC	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	mannose	mannose	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	endocytosis	endocytosis	NOUN	NN	Number=Sing	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8216
# text = Finally, we found that the addition of NAC to MLR between naive T cells and allogeneic DC resulted in a profound inhibition of alloreactive responses, which could be attributed to a defect of DC as APC-independent T cell responses were not inhibited by NAC.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	MLR	MLR	PROPN	NNP	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	allogeneic	allogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
18	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
19	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	alloreactive	alloreactive	ADJ	JJ	Degree=Pos	_	_	_	_
26	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	APC	APC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
41	T	t	NOUN	NN	Number=Sing	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
44	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8217
# text = Altogether, our results suggest that NAC might impair the generation of primary immune responses in humans through its inhibitory action on DC.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
8	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
9	impair	impair	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
21	action	action	NOUN	NN	Number=Sing	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8218
# text = Document 0030011365 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011365	0030011365	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8219
# text = Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes.
1	Extracellular	Extracelular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	1/2	1/2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	6	6	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8220
# text = In the present study we investigated the possible involvement of the mitogen-activated protein kinase family members extracellular-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) in mediating IL-6 gene expression in human monocytes, in particular their role in enhancing NF-kappa B activity.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
9	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	extracellular-regulated	extracellular-regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	1/2	1/2	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ERK	ERK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	1/	1/	SYM	SYM	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
31	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
32	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
33	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	mediating	mediat	ADJ	JJ	Degree=Pos	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	6	6	NUM	CD	NumType=Card	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
50	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
51	role	role	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	SCONJ	IN	_	_	_	_	_
53	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
54	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
57	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
58	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8221
# text = Freshly isolated monocytes treated with the protein phosphatase inhibitor okadaic acid secreted high levels of IL-6 protein, which coincided with enhanced binding activity of NF-kappa B as well as with phosphorylation and activation of the ERK1/2 and JNK proteins.
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
11	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
12	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	coincided	coincide	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	1/	1/	SYM	NFP	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	JNK	JNK	NUM	CD	NumType=Card	_	_	_	_
46	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8222
# text = The ERK pathway-specific inhibitor PD98059 inhibited IL-6 secretion from monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	PD98059	Pd98059	NOUN	NN	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8223
# text = Transient overexpression of inactive mutants of either Raf-1 or JNK1 showed that both pathways were involved in kappa B-dependent IL-6 promoter activity.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	either	either	CCONJ	CC	_	_	_	_	_
8	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	JNK1	JNK1	PROPN	NNP	Number=Sing	_	_	_	_
13	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8224
# text = By using PD98059, we demonstrated that the Raf1/MEK1/ERK1/2 pathway did not affect the DNA binding of NF-kappa B but, rather, acted at the level of transcriptional activity of NF-kappa B.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Raf1/MEK1/	Raf1/mek1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	ERK	ERK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
15	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	rather	rather	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	acted	act	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	level	level	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
41	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8225
# text = Interestingly, it was shown that NF-kappa B-mediated gene transcription, both in the context of the IL-6 promoter as well as on its own, was dependent on both serine kinase activity and interaction with c-Jun protein.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	context	context	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	as	as	ADV	RB	_	_	_	_	_
27	well	well	ADV	RB	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	own	own	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	both	both	DET	DT	_	_	_	_	_
37	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
46	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8226
# text = We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ERK1/2 and JNK pathway-dependent activation of NF-kappa B transcriptional capacity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	at	at	ADV	RB	_	_	_	_	_
15	least	least	ADV	RBS	Degree=Sup	_	_	_	_
16	partly	partly	ADV	RB	_	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	1/	1/	SYM	NFP	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8227
# text = Our results suggest that the JNK pathway may regulate NF-kappa B-mediated gene transcription through its phosphorylation and activation of c-Jun.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	JNK	JNK	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8228
# text = Document 0030011377 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011377	0030011377	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8229
# text = Differential effects of protein kinase C inhibitors on fibronectin-induced interleukin-beta gene transcription, protein synthesis and secretion in human monocytic cells.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	C	c	NOUN	NN	Number=Sing	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	fibronectin-induced	fibronectin-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8230
# text = Human monocytic cells express interleukin-1beta (IL-1beta) when stimulated with the extracellular matrix glycoprotein, fibronectin (FN).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
20	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	FN	FN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8231
# text = Protein kinase C (PKC) activation is considered important for this process; however, the metabolic steps at which PKC acts upon to mediate the FN-induced IL-1beta response remain unclear.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
19	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
23	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	FN	Fn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	bet	bet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	response	response	NOUN	NN	Number=Sing	_	_	_	_
37	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8232
# text = We performed an analysis of the mechanisms by which two PKC inhibitors, Calphostin C and Staurosporine, prevent the FN-induced IL-1beta response.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	which	which	DET	WDT	PronType=Int	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
12	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Calphostin	Calphostin	PROPN	NNP	Number=Sing	_	_	_	_
15	C	C	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Staurosporine	Staurosporine	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	prevent	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	FN	Fn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8233
# text = Both inhibitors blocked the secretion of IL-1beta protein into the media of peripheral blood mononuclear cells exposed to FN.
1	Both	both	DET	DT	_	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	media	media	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	FN	FN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8234
# text = Immunoprecipitation analysis revealed that under these circumstances, Calphostin C inhibited the production of IL-1beta protein, whereas Staurosporine allowed protein production, but inhibited its secretion.
1	Immunoprecipitation	Immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	under	under	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	circumstances	circumstance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Calphostin	Calphostin	PROPN	NNP	Number=Sing	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	whereas	whereas	SCONJ	IN	_	_	_	_	_
21	Staurosporine	Staurosporine	PROPN	NNP	Number=Sing	_	_	_	_
22	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8235
# text = To determine the mechanisms responsible for these differences, we turned to human U937 promonocytic cells.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	turned	turn	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	human	human	VERB	VB	VerbForm=Inf	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8236
# text = U937 cells transfected with the human full-length IL-1beta promoter connected to a luciferase reporter gene were submitted to transcription assays, Northern blotting, and DNA electrophoresis mobility gel shift assays.
1	U937	U937	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	length	length	NOUN	NN	Number=Sing	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	connected	connect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
19	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	submitted	submit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
28	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	electrophoresis	electrophoresis	NOUN	NN	Number=Sing	_	_	_	_
33	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
34	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
35	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
36	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8237
# text = These studies revealed that Calphostin C inhibited the nuclear translocation of the transcription factor activator protein-1 (AP-1) which is considered necessary for FN induction of IL-1beta gene transcription, and prevented the transcription of the IL-1beta gene.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Calphostin	Calphostin	PROPN	NNP	Number=Sing	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	_
7	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	activator	activator	CCONJ	CC	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	FN	Fn	ADJ	JJ	Degree=Pos	_	_	_	_
30	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8238
# text = In contrast, Staurosporine alone induced AP-1 translocation and stimulation of the gene.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Staurosporine	Staurosporine	PROPN	NNP	Number=Sing	_	_	_	_
5	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8239
# text = Overall, our data indicate that Calphostin C prevents the transcription of the IL-1beta gene thereby inhibiting protein synthesis.
1	Overall	overall	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Calphostin	Calphostin	PROPN	NNP	Number=Sing	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	_
9	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	thereby	thereby	ADV	RB	_	_	_	_	_
19	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8240
# text = Based on the high specificity of this compound for PKC, we conclude that PKC is necessary for FN-induced IL-1beta protein production.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	FN	FN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8241
# text = In contrast, Staurosporine prevented secretion of IL-1beta by unknown mechanisms.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Staurosporine	Staurosporine	PROPN	NNP	Number=Sing	_	_	_	_
5	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8242
# text = Document 0030011379 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011379	0030011379	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8243
# text = Dependence for the proliferative response to erythropoietin on an established erythroid differentiation program in a human hematopoietic cell line, UT-7.
1	Dependence	Dependence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	erythropoietin	erythropoietin	VERB	VB	VerbForm=Inf	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	program	program	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8244
# text = Erythroid differentiation involves the activation of a number of erythroid-specific genes, most of which, including the globin genes and the erythropoietin receptor (Epo-R) gene, are, at least in part, regulated by the transcription factor GATA-1.
1	Erythroid	Erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Int	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	at	at	ADV	RB	_	_	_	_	_
37	least	least	ADV	RBS	Degree=Sup	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
46	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8245
# text = In order to understand the relationship, if any, between expression of GATA-1, response to Epo and erythroid differentiation, we analyzed the expression of GATA-1, Epo-R and globin genes in an Epo-dependent human cell line, UT-7 Epo.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	if	if	SCONJ	IN	_	_	_	_	_
9	any	any	DET	DT	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-R	-r	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	Epo-dependent	Epo-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	7	7	NUM	CD	NumType=Card	_	_	_	_
49	Epo	Epo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8246
# text = The results were compared to those obtained with the parental granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent cell line, UT-7, which has a predominantly megakaryoblastic phenotype and is unable to proliferate continuously in the presence of Epo. UT-7 Epo and UT-7 expressed similar levels of GATA-1 mRNA and binding activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
7	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
11	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GM-CSF	GM-CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	predominantly	predominantly	ADV	RB	_	_	_	_	_
34	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
35	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
41	continuously	continuously	ADV	RB	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	Epo.	Epo.	PROPN	NNP	Number=Sing	_	_	_	_
47	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-7	-7	NUM	CD	NumType=Card	_	_	_	_
49	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	UT	ut	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	7	7	NUM	CD	NumType=Card	_	_	_	_
54	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
56	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	1	1	NUM	CD	NumType=Card	_	_	_	_
61	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
62	and	and	CCONJ	CC	_	_	_	_	_
63	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
64	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8247
# text = The two lines also expressed comparable levels of Epo-R mRNA while the number of Epo-binding sites on UT-7
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-R	-R	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	while	while	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Epo-	Epo-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 8248
# text = Epo cells was one-sixth the number of UT-7 cells (2400 +/- 3 vs. 13,800 +/- 300).
1	Epo	Epo	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	sixth	sixth	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	7	7	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	2400	2400	NUM	CD	NumType=Card	_	_	_	_
16	+/-	+/-	SYM	SYM	_	_	_	_	_
17	3	3	NUM	CD	NumType=Card	_	_	_	_
18	vs.	vs.	NOUN	NNS	Number=Plur	_	_	_	_
19	13,800	13,800	NUM	CD	NumType=Card	_	_	_	_
20	+/-	+/-	SYM	SYM	_	_	_	_	_
21	300	300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8249
# text = This difference in the number of binding sites could be due to differences in cell surface (UT-7 cells are 20% smaller than the parental UT-7 cells) or in receptor turnover.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	number	number	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	due	due	ADP	IN	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	7	7	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	%	%	SYM	NN	Number=Sing	_	_	_	_
25	smaller	smaller	ADJ	JJR	Degree=Cmp	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
29	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8250
# text = By Northern analysis, UT-7 cells expressed detectable levels of beta- and gamma-globin but not alpha-globin.
1	By	by	ADP	IN	_	_	_	_	_
2	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8251
# text = In comparison, UT-7
1	In	in	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 8252
# text = Epo cells expressed alpha-globin and higher levels of gamma-globin (5-fold) and beta-globin (from barely to clearly detectable).
1	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	higher	higher	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	from	from	ADP	IN	_	_	_	_	_
25	barely	barely	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	clearly	clearly	ADV	RB	_	_	_	_	_
28	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8253
# text = Globin chains (alpha, beta and gamma) were clearly detectable by affinity chromatography in UT-7
1	Globin	Globin	ADJ	JJ	Degree=Pos	_	_	_	_
2	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	clearly	clearly	ADV	RB	_	_	_	_	_
12	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
15	chromatography	chromatography	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 8254
# text = Epo but not in UT-7 cells.
1	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
2	but	but	CCONJ	CC	_	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8255
# text = The frequency of the cells which expressed beta- and gamma- globin genes in the two cell populations was measured by immunofluorescence with beta- and gamma-specific antibodies.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8256
# text = The number of gamma-positive cells and their fluorescence intensity were higher in UT-7
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
11	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 8257
# text = Epo than in UT-7 cells (0 to 17% barely positive cells and 23 to 40% clearly positive cells, respectively), indicating that the increase in globin mRNA observed in UT-7
1	Epo	Epo	ADV	RB	_	_	_	_	_
2	than	than	ADP	IN	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	0	0	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	%	%	SYM	NN	Number=Sing	_	_	_	_
13	barely	barely	ADV	RB	_	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	23	23	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	%	%	SYM	NN	Number=Sing	_	_	_	_
21	clearly	clearly	ADV	RB	_	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	globin	globin	PROPN	NNP	Number=Sing	_	_	_	_
34	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
35	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-7	-7	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 8258
# text = Epo is due to both an increase of gene expression per cell and an increase in numbers of cells containing gamma-globin.
1	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	both	both	CCONJ	CC	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	per	per	ADP	IN	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8259
# text = The levels of GATA-1, Epo-R and globin mRNA expressed were not affected by a 24-hour incubation of either cell line with Epo, GM-CSF or interleukin-3 (IL-3).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-R	-R	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	globin	globin	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
22	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	either	either	DET	DT	_	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	3	3	NUM	CD	NumType=Card	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8260
# text = (ABSTRACT TRUNCATED AT 400 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	400	400	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8261
# text = Document 0030011381 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011381	0030011381	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8262
# text = Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanism.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	disrupted	disrupt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	BRLF1	Brlf1	NUM	CD	NumType=Card	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8263
# text = Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis, is a human herpesvirus associated with epithelial cell malignancies (nasopharyngeal carcinoma) as well as B-cell malignancies.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	causative	causative	ADJ	JJ	Degree=Pos	_	_	_	_
11	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
14	mononucleosis	mononucleosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
27	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	as	as	ADV	RB	_	_	_	_	_
30	well	well	ADV	RB	Degree=Pos	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8264
# text = Understanding how viral latency is disrupted is a central issue in herpesvirus biology.
1	Understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
2	how	how	ADV	WRB	PronType=Int	_	_	_	_
3	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
4	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	disrupted	disrupt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
10	issue	issue	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
13	biology	biology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8265
# text = Epithelial cells are the major site of lytic EBV replication within the human host, and viral reactivation occurs in EBV-associated nasopharyngeal carcinomas.
1	Epithelial	Epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
18	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
19	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
25	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8266
# text = It is known that expression of a single viral immediate-early protein, BZLF1, is sufficient to initiate the switch from latent to lytic infection in B cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	latent	latent	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8267
# text = Cellular regulation of BZLF1 transcription is therefore thought to play a key role in regulating the stringency of viral latency.
1	Cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BZLF1	BZLF1	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	therefore	therefore	ADV	RB	_	_	_	_	_
8	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	stringency	stringency	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
20	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8268
# text = Here we show that, unexpectedly, expression of another viral immediate-early protein, BRLF1, can disrupt viral latency in an epithelial cell-specific fashion.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	another	another	DET	DT	_	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	BRLF1	BRLF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
21	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
22	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8269
# text = Therefore, the mechanisms leading to disruption of EBV latency appear to be cell-type specific.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
10	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
11	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8270
# text = Document 0030011382 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011382	0030011382	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8271
# text = Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation [published erratum appears in Biochim Biophys Acta 1995 Dec 27;1264(3):409]
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
5	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	hydroxyurea	hydroxyurea	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	K562	K562	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
19	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	Biochim	Biochim	PROPN	NNP	Number=Sing	_	_	_	_
22	Biophys	Biophys	PROPN	NNP	Number=Sing	_	_	_	_
23	Acta	Acta	PROPN	NNP	Number=Sing	_	_	_	_
24	1995	1995	NUM	CD	NumType=Card	_	_	_	_
25	Dec	Dec	PROPN	NNP	Number=Sing	_	_	_	_
26	27;1264	27;1264	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	:409	:409	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8272
# text = Hydroxyurea (HU) is an antitumor agent which also induces hemoglobinization during erythroid differentiation.
1	Hydroxyurea	Hydroxyurea	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	antitumor	antitumor	ADJ	JJ	Degree=Pos	_	_	_	_
8	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	hemoglobinization	hemoglobinization	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8273
# text = In addition, HU stimulates the synthesis of fetal hemoglobin in sickle cell anemia patients.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	HU	Hu	PRON	PRP	Case=Nom|Person=2|PronType=Prs	_	_	_	_
5	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
10	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	anemia	anemia	ADP	IN	_	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8274
# text = To further understand its mechanism of action, we investigated the effects of HU on regulation of c-jun expression prior to the onset of erythroid differentiation of K562 cells.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HU	Hu	PRON	PRP	Case=Acc|Person=2|PronType=Prs	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	K562	K562	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8275
# text = HU induced a dose-dependent stimulation of c-jun synthesis.
1	HU	Hu	PRON	PRP	Case=Nom|Person=2|PronType=Prs	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8276
# text = The levels of c-jun mRNA was elevated 4 to 7.5-fold by HU within 2 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	7.5	7.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8277
# text = This was followed by a gradual decline to the basal level by 24 h.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	gradual	gradual	ADJ	JJ	Degree=Pos	_	_	_	_
7	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	24	24	NUM	CD	NumType=Card	_	_	_	_
14	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8278
# text = Both nuclear run-on and actinomycin D pulse experiments strongly indicate that HU regulates c-jun mRNA expression by increasing the rate of synthesis as well as stabilizing the c-jun mRNA.
1	Both	both	DET	DT	_	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	on	on	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	actinomycin	actinomycin	ADJ	JJ	Degree=Pos	_	_	_	_
8	D	D	NOUN	NN	Number=Sing	_	_	_	_
9	pulse	pulse	NOUN	NN	Number=Sing	_	_	_	_
10	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
11	strongly	strongly	ADV	RB	_	_	_	_	_
12	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
15	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	jun	jun	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
26	as	as	ADV	RB	_	_	_	_	_
27	well	well	ADV	RB	Degree=Pos	_	_	_	_
28	as	as	SCONJ	IN	_	_	_	_	_
29	stabilizing	stabilize	VERB	VBG	VerbForm=Ger	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
32	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
33	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8279
# text = In addition, the level of jun protein was elevated by 2 to 5-fold within 4 h in HU treated cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	level	level	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	h	h	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
22	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8280
# text = Furthermore, concentrations of HU below 250 microM slightly increased the 5X AP-1/CAT activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
6	below	below	ADV	RB	_	_	_	_	_
7	250	250	NUM	CD	NumType=Card	_	_	_	_
8	microM	microm	PROPN	NNP	Number=Sing	_	_	_	_
9	slightly	slightly	ADV	RB	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	5X	5X	PROPN	NNP	Number=Sing	_	_	_	_
13	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8281
# text = These results strongly suggest that HU induces both transcriptional and post-transcription regulation of c-jun during erythroid differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	post	post	X	AFX	_	_	_	_	SpaceAfter=No
12	-transcription	-transcription	NOUN	NN	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8282
# text = Document 0030011392 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011392	0030011392	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8283
# text = Lymphocytes from CML patients lack a 47 kDa factor having affinity for a genomic sterol regulatory sequence.
1	Lymphocytes	Lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	CML	CML	PROPN	NNP	Number=Sing	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	47	47	NUM	CD	NumType=Card	_	_	_	_
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
11	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
15	sterol	sterol	NOUN	NN	Number=Sing	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8284
# text = Deranged cellular cholesterol homeostasis has been widely recognized in the initiation as well as progression of various types of cancers including chronic myeloid leukaemia (CML).
1	Deranged	Derange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	cholesterol	cholesterol	NOUN	NN	Number=Sing	_	_	_	_
4	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	widely	widely	ADV	RB	_	_	_	_	_
8	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
23	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
24	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CML	CML	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8285
# text = Since the human genomic sterol regulatory element (SRE) has been shown to regulate various key genes involved in this phenomenon, the present study revealed the existence of a unique 47 kDa protein factor having affinity for this SRE sequence in lymphocytes from normal subjects, as well as its absence in lymphocytes from untreated CML patients.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
5	sterol	sterol	NOUN	NN	Number=Sing	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
17	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
26	study	study	NOUN	NN	Number=Sing	_	_	_	_
27	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
33	47	47	NUM	CD	NumType=Card	_	_	_	_
34	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
37	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
38	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
41	SRE	Sre	NOUN	NN	Number=Sing	_	_	_	_
42	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
45	from	from	ADP	IN	_	_	_	_	_
46	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
47	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	as	as	ADV	RB	_	_	_	_	_
50	well	well	ADV	RB	Degree=Pos	_	_	_	_
51	as	as	ADP	IN	_	_	_	_	_
52	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
53	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
56	from	from	ADP	IN	_	_	_	_	_
57	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
58	CML	cml	NOUN	NN	Number=Sing	_	_	_	_
59	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8286
# text = However, this factor appeared when these CML patients achieved complete haematological remission (CHR) through alpha-interferon therapy.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	when	when	ADV	WRB	PronType=Int	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	CML	cml	ADJ	JJ	Degree=Pos	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	achieved	achieve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
12	haematological	haematological	ADJ	JJ	Degree=Pos	_	_	_	_
13	remission	remission	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CHR	CHR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
21	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8287
# text = Furthermore, an inverse relationship was also observed between the LDL receptor gene expression at the transcriptional level and the binding affinity of this 47 kDa protein factor to the SRE sequence.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inverse	inverse	ADJ	JJ	Degree=Pos	_	_	_	_
5	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	LDL	Ldl	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	47	47	NUM	CD	NumType=Card	_	_	_	_
26	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	SRE	Sre	PROPN	NNP	Number=Sing	_	_	_	_
32	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8288
# text = Based upon these results we propose that this factor may have a role in pathophysiology of chronic myeloid leukaemia.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	upon	upon	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
18	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
19	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8289
# text = Document 0030011394 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011394	0030011394	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8290
# text = Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8291
# text = The zinc finger transcription factor GATA-1 is a major regulator of gene expression in erythroid, megakaryocyte, and mast cell lineages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
3	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	megakaryocyte	megakaryocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	mast	mast	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8292
# text = GATA-1 binds to WGATAR consensus motifs in the regulatory regions of virtually all erythroid cell-specific genes.
1	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	WGATAR	Wgatar	VERB	VB	VerbForm=Inf	_	_	_	_
7	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	virtually	virtually	ADV	RB	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8293
# text = Analyses with cultured cells and cell-free systems have provided strong evidence that GATA-1 is involved in control of globin gene expression during erythroid differentiation.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
9	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
13	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	control	control	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	during	during	ADP	IN	_	_	_	_	_
27	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8294
# text = Targeted mutagenesis of the GATA-1 gene in embryonic stem cells has demonstrated its requirement in normal erythroid development.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	mutagenesis	mutagenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
11	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8295
# text = Efficient rescue of the defect requires an intact GATA element in the distal promoter, suggesting autoregulatory control of GATA-1 transcription.
1	Efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
2	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
6	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
9	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8296
# text = To examine whether GATA-1 expression involves additional regulatory factors or is maintained entirely by an autoregulatory loop, we have used a transient heterokaryon system to test the ability of erythroid factors to activate the GATA-1 gene in nonerythroid nuclei.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	entirely	entirely	ADV	RB	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
26	heterokaryon	heterokaryon	NOUN	NN	Number=Sing	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	nonerythroid	nonerythroid	ADJ	JJ	Degree=Pos	_	_	_	_
44	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8297
# text = We show here that proerythroblasts and mature erythroid cells contain a diffusible activity (TAG) capable of transcriptional activation of GATA-1 and that this activity decreases during the terminal differentiation of erythroid cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	proerythroblasts	proerythroblast	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
8	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	diffusible	diffusible	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TAG	tag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
30	during	during	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8298
# text = Nuclei from GATA-1- mutant embryonic stem cells can still be reprogrammed to express their globin genes in erythroid heterokaryons, indicating that de novo induction of GATA-1 is not required for globin gene activation following cell fusion.
1	Nuclei	Nuclei	PROPN	NNP	Number=Sing	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	_
7	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
8	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
9	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	still	still	ADV	RB	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	reprogrammed	reprogram	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	heterokaryons	heterokaryon	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	de	de	PROPN	NNP	Number=Sing	_	_	_	_
27	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8299
# text = Document 0030011398 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011398	0030011398	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8300
# text = Possible role of nuclear factor-kappa B activity in germline C epsilon transcription in a human Burkitt lymphoma B cell line.
1	Possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	germline	germline	PROPN	NNP	Number=Sing	_	_	_	_
12	C	C	PROPN	NNP	Number=Sing	_	_	_	_
13	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
20	B	B	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8301
# text = Nuclear factor-kappa B (NF-kappa B) plays a broad role in gene regulation, but it is not evident whether NF-kappa B acts as a messenger system for germline C epsilon transcription.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	broad	broad	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
25	whether	whether	SCONJ	IN	_	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
34	system	system	NOUN	NN	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
37	C	c	NOUN	NN	Number=Sing	_	_	_	_
38	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8302
# text = We report here that the signaling cascade triggered by interleukin-4 (IL-4) or anti-CD40 monoclonal antibody (mAb) participates in NF-kappa B activation responsible for germline C epsilon transcription in a human Burkitt lymphoma B cell line, DND39.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
7	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
8	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	_
20	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
21	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	germline	germline	PROPN	NNP	Number=Sing	_	_	_	_
35	C	C	PROPN	NNP	Number=Sing	_	_	_	_
36	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	_
42	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
45	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	DND39	DND39	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8303
# text = Both IL-4 and anti-CD40 mAb induced activation of phosphatidylinositol 3-kinase (PI3-kinase), translocation of a zeta isoform of protein kinase C, and nuclear expression of NF-kappa B.
1	Both	both	DET	DT	_	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	_
7	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	PI3	PI3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
25	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8304
# text = All such events were abrogated by treatment with LY294002, a specific inhibitor of PI3-kinase.
1	All	all	DET	DT	_	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	LY	Ly	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	294002	294002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	PI3	PI3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-kinase	-kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8305
# text = In addition, N-acetyl-L-cysteine (NAC), a potent antioxidant, decreased NF-kappa B activation caused by IL-4, anti-CD40 mAb, or their combination.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	N-acetyl	N-acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-L-	-L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
13	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	anti-CD40	anti-CD40	PROPN	NNP	Number=Sing	_	_	_	_
28	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8306
# text = NAC was also effective in diminishing germline C epsilon transcription, and its potency was higher in cultures costimulated with IL-4 and anti-CD40 mAb than in those stimulated with IL-4 alone.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	diminishing	diminish	VERB	VBG	VerbForm=Ger	_	_	_	_
7	germline	germline	PROPN	NNP	Number=Sing	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	_
9	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
14	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
20	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	_
27	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	4	4	X	GW	_	_	_	_	_
36	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8307
# text = These results indicate that IL-4 and ligation of CD40 induce NF-kappa B expression via at least a mechanism dependent on the PI3-kinase pathway and suggest that NF-kappa B sensitive to NAC may play a role in regulating germline C epsilon transcription.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
12	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	at	at	ADV	RB	_	_	_	_	_
20	least	least	ADV	RBS	Degree=Sup	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	PI3	PI3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-kinase	-kinase	NOUN	NN	Number=Sing	_	_	_	_
28	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	role	role	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	SCONJ	IN	_	_	_	_	_
44	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
45	germline	germline	PROPN	NNP	Number=Sing	_	_	_	_
46	C	C	PROPN	NNP	Number=Sing	_	_	_	_
47	epsilon	epsilon	ADP	IN	_	_	_	_	_
48	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8308
# text = Document 0030011402 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011402	0030011402	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8309
# text = Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat-driven transcription in human monocytes.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
6	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
7	receptors	receptor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
13	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
14	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8310
# text = Elevation of the levels of circulating immune complexes frequently accompanies HIV-1 infection and is a prognostic indicator of clinical progression from asymptomatic infection to AIDS.
1	Elevation	Elevation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	SCONJ	IN	_	_	_	_	_
6	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	immune	immune	PRON	NN	Number=Sing	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	frequently	frequently	ADV	RB	_	_	_	_	_
10	accompanies	accompany	NOUN	NNS	Number=Plur	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	prognostic	prognostic	ADJ	JJ	Degree=Pos	_	_	_	_
19	indicator	indicator	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
22	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	asymptomatic	asymptomatic	ADJ	JJ	Degree=Pos	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	AIDS	Aid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8311
# text = Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-linking	-link	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
9	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
10	RI	RI	PROPN	NNP	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
13	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
14	RII	RII	PROPN	NNP	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	IgG	Igg	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
23	-Fc	-Fc	X	GW	_	_	_	_	_
24	gamma	gamma	X	GW	_	_	_	_	_
25	R	R	X	GW	_	_	_	_	_
26	mAb	mAb	X	GW	_	_	_	_	_
27	activates	activate	X	GW	_	_	_	_	_
28	HIV	HIV	X	GW	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	line	line	NOUN	NN	Number=Sing	_	_	_	_
39	BF24	BF24	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
43	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
47	from	from	ADP	IN	_	_	_	_	_
48	HIV	haHive	PROPN	NNP	Number=Sing	_	_	_	_
49	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
51	as	as	SCONJ	IN	_	_	_	_	_
52	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	by	by	ADP	IN	_	_	_	_	_
54	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
55	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8312
# text = In THP-1 cells, Fc gamma R cross-linking induced NF-kappa B, which is known to bind to the regulatory region of the long terminal repeat (LTR) of HIV-1 and to activate HIV-1 transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
8	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
9	R	R	PROPN	NNP	Number=Sing	_	_	_	_
10	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
30	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
31	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
42	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8313
# text = Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1-LTR-driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking.
1	Anti-TNF	Anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	anti-IL	anti-il	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
36	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
37	R	R	PROPN	NNP	Number=Sing	_	_	_	_
38	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8314
# text = These results indicate that Fc gamma R can mediate a TNF-alpha-dependent induction of HIV-1 gene transcription and suggest that immune complexes may contribute to the pathophysiology of HIV-1 infection by augmenting viral replication in monocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
6	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
7	R	be	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
27	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
38	by	by	SCONJ	IN	_	_	_	_	_
39	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
40	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
41	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8315
# text = Document 0030011403 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011403	0030011403	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8316
# text = Tobacco smoke induces coordinate activation of HSF and inhibition of NFkappaB in human monocytes: effects on TNFalpha release.
1	Tobacco	Tobacco	PROPN	NNP	Number=Sing	_	_	_	_
2	smoke	smeak	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
4	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HSF	Hsf	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
19	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8317
# text = Tobacco smoke (TS) exposure is a major risk factor for human disease, and macrophages of healthy smokers have a depressed capacity to release cytokines, including tumor necrosis factor (TNF)alpha.
1	Tobacco	Tobacco	PROPN	NNP	Number=Sing	_	_	_	_
2	smoke	smoke	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	TS	TS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
20	smokers	smoker	NOUN	NNS	Number=Plur	_	_	_	_
21	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	depressed	depressed	ADJ	JJ	Degree=Pos	_	_	_	_
24	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
27	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
30	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
31	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8318
# text = TS induces the synthesis of heat shock (HS)/stress proteins (HSP), and, in particular, of Hsp70.
1	TS	T	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
7	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HS	H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HSP	HSP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Hsp70	Hsp70	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8319
# text = We determined whether Hsp70 induction by TS was mediated by the activation of the HS transcription factor, HSF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	Hsp70	Hsp70	NUM	CD	NumType=Card	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TS	TS	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	HSF	HSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8320
# text = HSF activation has been shown to inhibit NFkappaB.
1	HSF	Hsf	NOUN	NN	Number=Sing	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
8	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8321
# text = Thus, we also determined the effects of TS on NFkappaB.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TS	TS	PROPN	NNP	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8322
# text = U937 cells and human peripheral blood monocytes were exposed to TS, binding activities of the respective transcription factors were analyzed, and Hsp70 expression and TNFalpha release were determined in parallel.
1	U937	U937	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	TS	TS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Hsp70	Hsp70	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
28	release	release	NOUN	NN	Number=Sing	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8323
# text = TS activated HSF, which was associated with Hsp70 overexpression and inhibition of NFkappaB binding activity and TNFalpha release.
1	TS	TS	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	HSF	HSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	Hsp70	Hsp70	NUM	CD	NumType=Card	_	_	_	_
10	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
19	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8324
# text = The altered cytokine profile observed in smokers may relate to an HSF/Hsp70-mediated inhibition of NFkappaB activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	smokers	smoker	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	relate	relate	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	HSF	HSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Hsp70	Hsp70	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-mediated	-mediated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFkappaB	NFkappaB	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8325
# text = Copyright 1998 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1998	1998	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press	Press	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8326
# text = Document 0030011405 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011405	0030011405	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8327
# text = Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR2 mRNA.
1	Adherence	Adherence	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
8	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	EGR2	EGR2	NUM	CD	NumType=Card	_	_	_	_
26	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8328
# text = Adherence is an important initial step in the transition of a circulating monocyte to a tissue macrophage.
1	Adherence	Adherence	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
6	step	step	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
17	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8329
# text = This differentiation is accompanied by an augmented capacity to generate growth factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
11	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8330
# text = We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding profibrotic growth factors such as platelet-derived growth factor B subunit (PDGF[B]) and transforming growth factor-beta (TGF-beta).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
5	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
6	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	culminating	culminat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
24	profibrotic	profibrotic	ADJ	JJ	Degree=Pos	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
44	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
45	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-beta	-beta	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8331
# text = After in vitro adherence, human monocytes had a biphasic increase in PDGF(B) mRNA with peaks at 6 h and 13 d.
1	After	after	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
4	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	peaks	peak	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	h	h	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	13	13	NUM	CD	NumType=Card	_	_	_	_
25	d	would	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8332
# text = No increase in TGF-beta mRNA was observed.
1	No	no	DET	DT	_	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8333
# text = The 6-h increase in PDGF(B) mRNA was adherence dependent, and in addition, was abrogated when the cytoskeletal integrity was compromised by cytochalasin D.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	h	h	NOUN	NN	Number=Sing	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	when	when	ADV	WRB	PronType=Int	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cytoskeletal	cytoskeletal	ADJ	JJ	Degree=Pos	_	_	_	_
25	integrity	integrity	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	compromised	compromise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	cytochalasin	cytochalasin	PROPN	NNP	Number=Sing	_	_	_	_
30	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8334
# text = The 6-h increase in PDGF(B) mRNA was unaltered by adherence in the presence of the monocyte stimulus lipopolysaccharide.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	h	h	NOUN	NN	Number=Sing	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	unaltered	unalter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
22	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
23	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8335
# text = Adherence to either fibronectin or collagen-coated plastic had little consistent effect on PDGF(B) mRNA accumulation.
1	Adherence	Adherence	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	either	either	CCONJ	CC	_	_	_	_	_
4	fibronectin	fibronectin	VERB	VB	VerbForm=Inf	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	collagen	collagen	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	coated	coate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
12	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8336
# text = The increased PDGF(B) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the early growth response genes c-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PDGF	Pdgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
25	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	20	20	NUM	CD	NumType=Card	_	_	_	_
30	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
34	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
40	at	at	ADP	IN	_	_	_	_	_
41	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	24	24	NUM	CD	NumType=Card	_	_	_	_
44	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8337
# text = The increase in c-jun and EGR2, but not c-fos, mRNA was also abrogated by cytochalasin D.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	cytochalasin	cytochalasin	PROPN	NNP	Number=Sing	_	_	_	_
20	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8338
# text = These observations suggest that adherence results in increases of c-fos, c-jun, EGR2, and PDGF(B) mRNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	PDGF	Pdgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8339
# text = In addition, the increases in c-jun, EGR2, and PDGF(B) may depend on cytoskeletal rearrangement.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	EGR2	Egr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	PDGF	PDGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	cytoskeletal	cytoskeletal	ADJ	JJ	Degree=Pos	_	_	_	_
21	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8340
# text = Modulation of these events at the time of adherence offers a mechanism by which differential priming of the cells may be accomplished.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	time	time	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
10	offers	offer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
16	priming	priming	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	accomplished	accomplish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8341
# text = Document 0030011412 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011412	0030011412	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8342
# text = NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB-	kappaB-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	x	x	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Bfl	Bfl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-1/A1	-1/A1	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
19	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
20	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8343
# text = Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	thymus	thymus	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	humoral	humoral	ADJ	JJ	Degree=Pos	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	rescuing	rescue	VERB	VBG	VerbForm=Ger	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8344
# text = Many of the effects of CD40 are believed to be achieved through altered gene expression.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8345
# text = In addition to Bcl-x, a known CD40-regulated antiapoptotic molecule, we identified a related antiapoptotic molecule, A1/Bfl-1, as a CD40-inducible gene.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	x	x	SYM	SYM	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	A1/	A1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
24	Bfl	Bfl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8346
# text = Inhibition of the NF-kappaB pathway by overexpression of a dominant-active inhibitor of NF-kappaB abolished CD40-induced up-regulation of both the Bfl-1 and Bcl-x genes and also eliminated the ability of CD40 to rescue Fas-induced cell death.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Bfl	Bfl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-1	-1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	x	x	NOUN	NN	Number=Sing	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	also	also	ADV	RB	_	_	_	_	_
38	eliminated	eliminate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	rescue	rescue	VERB	VB	VerbForm=Inf	_	_	_	_
45	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8347
# text = Within the upstream promoter region of Bcl-x, a potential NF-kappaB-binding sequence was found to support NF-kappaB-dependent transcriptional activation.
1	Within	within	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	x	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	support	support	VERB	VB	VerbForm=Inf	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8348
# text = Furthermore, expression of physiological levels of Bcl-x protected B cells from Fas-mediated apoptosis in the absence of NF-kappaB signaling.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	x	x	SYM	SYM	_	_	_	_	_
11	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8349
# text = Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
12	proceeds	proceed	NOUN	NNS	Number=Plur	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8350
# text = Document 0030011413 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011413	0030011413	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8351
# text = Regulation of low shear flow-induced HAEC VCAM-1 expression and monocyte adhesion.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
4	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
5	flow	flow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	HAEC	Haec	PROPN	NNP	Number=Sing	_	_	_	_
9	VCAM	VCAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
15	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8352
# text = We recently reported that prolonged exposure of human aortic endothelial cells (HAEC) to low shear stress flow patterns is associated with a sustained increase in the activated form of the transcriptional regulator nuclear factor-kappaB (NF-kappaB).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	recently	recently	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	prolonged	prolonge	ADJ	JJ	Degree=Pos	_	_	_	_
6	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	HAEC	HAEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
18	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
19	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
20	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	form	form	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
34	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
35	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8353
# text = Here we investigate the hypothesis that low shear-induced activation of NF-kappaB is responsible for enhanced expression of vascular cell adhesion molecule (VCAM-1) resulting in augmented endothelial cell-monocyte (EC-Mn) adhesion and that this activation is dependent on intracellular oxidant activity.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
25	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	augmented	augment	ADJ	JJ	Degree=Pos	_	_	_	_
34	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	that	that	SCONJ	IN	_	_	_	_	_
46	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
50	on	on	ADP	IN	_	_	_	_	_
51	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
52	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
53	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8354
# text = Before exposure to low shear (2 dyn/cm2) for 6 h, HAEC were preincubated with or without the antioxidants pyrrolidine dithiocarbamate (PDTC) or N-acetyl-L-cysteine (NAC).
1	Before	before	ADP	IN	_	_	_	_	_
2	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
5	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	dyn/	dyn/	SYM	SYM	_	_	_	_	SpaceAfter=No
9	cm2	cm2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	HAEC	Haec	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	without	without	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
23	pyrrolidine	pyrrolidine	PRON	PRP	_	_	_	_	_
24	dithiocarbamate	dithiocarbamate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-L-	-l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8355
# text = PDTC strongly inhibited low shear-induced activation of NF-kappaB, expression of VCAM-1, and EC-Mn adhesion.
1	PDTC	Pdtc	PROPN	NNP	Number=Sing	_	_	_	_
2	strongly	strongly	ADV	RB	_	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
5	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8356
# text = Paradoxically, NAC exerted a positive effect on low shear-induced VCAM-1 expression and EC-Mn adhesion and only slightly downregulated NF-kappaB activation.
1	Paradoxically	paradoxically	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
4	exerted	exert	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
10	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
21	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	only	only	ADV	RB	_	_	_	_	_
24	slightly	slightly	ADV	RB	_	_	_	_	_
25	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8357
# text = However, cytokine-induced NF-kappaB activation and VCAM-1 expression are blocked by both PDTC and NAC.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8358
# text = These data suggest that NF-kappaB plays a key role in low shear-induced VCAM-1 expression and that pathways mediating low shear- and cytokine-induced EC-Mn adhesion may be differentially regulated.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
24	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
25	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
26	shear	shear	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
37	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
38	differentially	differentially	ADV	RB	_	_	_	_	_
39	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8359
# text = Document 0030011414 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011414	0030011414	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8360
# text = The small GTP-binding protein Rho potentiates AP-1 transcription in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	GTP-	Gtp-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
7	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8361
# text = The Rho family of small GTP-binding proteins is involved in the regulation of cytoskeletal structure, gene transcription, specific cell fate development, and transformation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	GTP-	Gtp-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytoskeletal	cytoskeletal	ADJ	JJ	Degree=Pos	_	_	_	_
16	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	fate	fate	NOUN	NN	Number=Sing	_	_	_	_
24	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8362
# text = We demonstrate in this report that overexpression of an activated form of Rho enhances AP-1 activity in Jurkat T cells in the presence of phorbol myristate acetate (PMA), but activated Rho (V14Rho) has little or no effect on NFAT, Oct-1, and NF-kappaB enhancer element activities under similar conditions.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	form	form	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
14	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
28	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
29	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	V14	V14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	no	no	DET	DT	_	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
46	on	on	ADP	IN	_	_	_	_	_
47	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
56	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
57	element	element	NOUN	NN	Number=Sing	_	_	_	_
58	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
59	under	under	ADP	IN	_	_	_	_	_
60	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
61	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8363
# text = Overexpression of a V14Rho construct incapable of membrane localization (CAAX deleted) abolishes PMA-induced AP-1 transcriptional activation.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	V14	V14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
6	construct	construct	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	incapable	incapable	ADJ	JJ	Degree=Pos	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
10	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CAAX	CAAX	NOUN	NN	Number=Sing	_	_	_	_
13	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8364
# text = The effect of Rho on AP-1 is independent of the mitogen-activated protein kinase pathway, as a dominant-negative MEK and a MEK inhibitor (PD98059) did not affect Rho-induced AP-1 activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dominant	dominant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	MEK	Mek	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	MEK	Mek	PROPN	NNP	Number=Sing	_	_	_	_
29	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
36	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8365
# text = V14Rho binds strongly to protein kinase Calpha (PKCalpha) in vivo; however, deletion of the CAAX site on V14Rho severely diminished this association.
1	V14	V14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
3	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	Calpha	Calpha	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PKCalpha	PKCalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CAAX	CAAX	PROPN	NNP	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	V14	V14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
25	severely	severely	ADV	RB	_	_	_	_	_
26	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	association	association	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8366
# text = Evidence for a role for PKCalpha as an effector of Rho was obtained by the observation that coexpression of the N-terminal domain of PKCalpha blocked the effects of activated Rho plus PMA on AP-1 transcriptional activity.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	PKCalpha	PKCalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	PKCalpha	PKCalpha	PROPN	NNP	Number=Sing	_	_	_	_
26	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	Rho	Rho	PROPN	NNP	Number=Sing	_	_	_	_
32	plus	plus	CCONJ	CC	_	_	_	_	_
33	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
39	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8367
# text = These data suggest that Rho potentiates AP-1 transcription during T-cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Rho	Rho	PRON	WP	PronType=Int	_	_	_	_
6	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8368
# text = Document 0030011420 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011420	0030011420	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8369
# text = Fibrinogen activates NF-kappa B transcription factors in mononuclear phagocytes.
1	Fibrinogen	Fibrinogen	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8370
# text = Adhesion to extracellular matrices is known to modulate leukocyte activation, although the mechanisms are not fully understood.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	matrices	matrice	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	although	although	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	fully	fully	ADV	RB	_	_	_	_	_
18	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8371
# text = Mononuclear phagocytes are exposed to fibrinous provisional matrix throughout migration into inflammatory foci, so this study was undertaken to determine whether fibrinogen triggers activation of NF-kappa B transcription factors.
1	Mononuclear	Mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	fibrinous	fibrinous	VERB	VB	VerbForm=Inf	_	_	_	_
7	provisional	provisional	ADJ	JJ	Degree=Pos	_	_	_	_
8	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
9	throughout	throughout	ADP	IN	_	_	_	_	_
10	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	foci	foci	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	so	so	ADV	RB	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	study	study	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	undertaken	undertake	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
22	whether	whether	SCONJ	IN	_	_	_	_	_
23	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	_
24	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8372
# text = U937 cells differentiated with PMA in nonadherent culture were shown to express two fibrinogen-binding integrins, predominately CD11b/CD18, and to a lesser extent, CD11c/CD18. Cells stimulated with fibrinogen (10-100 microg/ml)/Mn2+ (50 microM) for 2 h were examined by electrophoretic mobility shift assay.
1	U937	U937	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	nonadherent	nonadherent	ADJ	JJ	Degree=Pos	_	_	_	_
8	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	predominately	predominately	ADV	RB	_	_	_	_	_
20	CD11b/CD18	CD11b/CD18	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
26	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	CD11c/CD18	CD11c/CD18	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_
30	Cells	cells	PROPN	NNPS	Number=Plur	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	100	100	NUM	CD	NumType=Card	_	_	_	_
38	microg/ml)/Mn2+	microg/ml)/mn2+	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	50	50	NUM	CD	NumType=Card	_	_	_	_
41	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	h	h	NOUN	NN	Number=Sing	_	_	_	_
46	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
50	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
51	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
52	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8373
# text = NF-kappa B activation, minimal in unstimulated cells, was substantially up-regulated by fibrinogen.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	substantially	substantially	ADV	RB	_	_	_	_	_
14	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8374
# text = Fibrinogen also caused activation of AP-1, but not SP1 or cAMP response element-binding protein (CREB) factors.
1	Fibrinogen	Fibrinogen	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8375
# text = Blocking mAbs against CD18 and CD11b abrogated fibrinogen-induced NF-kappa B activation.
1	Blocking	Blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
2	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
3	against	against	ADP	IN	_	_	_	_	_
4	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	18	18	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	CD11	CD11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	b	b	NOUN	NN	Number=Sing	_	_	_	_
9	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	fibrinogen	fibrinogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8376
# text = To determine the effects on transcriptional regulation, U937 cells were transfected with a plasmid containing the HIV-1 enhancer (bearing two NF-kappa B sites) coupled to a chloramphenicol acetyltransferase (CAT) reporter.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	U937	U937	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
35	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8377
# text = Cells were subsequently stimulated with 1) PMA for 24 h, inducing CAT activity by 2.6-fold, 2) fibrinogen/Mn2+ for 2 h, inducing CAT activity by 3.2-fold, or 3) costimulation with fibrinogen and PMA, inducing 5.7-fold the CAT activity induced by PMA alone.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	subsequently	subsequently	ADV	RB	_	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	PMA	Pma	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	24	24	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
14	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	2.6	2.6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	Mn2	Mn2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
32	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	3.2	3.2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	3	3	X	LS	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	fibrinogen	fibrinogen	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
49	5.7	5.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
54	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
55	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	by	by	ADP	IN	_	_	_	_	_
57	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
58	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8378
# text = We conclude that contact with fibrinogen-derived proteins may contribute to mononuclear phagocyte activation by signaling through CD11b/CD18, resulting in selective activation of transcriptional regulatory factors, including NF-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	fibrinogen	fibrinogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	mononuclear	mononuclear	VERB	VB	VerbForm=Inf	_	_	_	_
14	phagocyte	phagocyte	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	CD11b/CD18	CD11b/CD18	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8379
# text = Document 0030011421 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011421	0030011421	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8380
# text = Alteration of a single serine in the basic domain of the Epstein-Barr virus ZEBRA protein separates its functions of transcriptional activation and disruption of latency.
1	Alteration	Alteration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
5	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	separates	separate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8381
# text = The ZEBRA protein from Epstein-Barr virus (EBV) activates a switch from the latent to the lytic expression program of the virus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	latent	latent	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	program	program	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8382
# text = ZEBRA, a member of the bZIP family of DNA-binding proteins, is a transcriptional activator capable of inducing expression from viral lytic cycle promoters.
1	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	member	member	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	bZIP	bZIP	PROPN	NNP	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
19	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	SCONJ	IN	_	_	_	_	_
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
25	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8383
# text = It had previously been thought that ZEBRA's capacity to disrupt EBV latency resided primarily in its ability to activate transcription of genes that encode products required for lytic replication.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
13	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
14	resided	reside	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	primarily	primarily	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	encode	encode	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	products	product	NOUN	NNS	Number=Plur	_	_	_	_
27	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8384
# text = We generated a point mutant of ZEBRA, Z(S186A), that was not impaired in its ability to activate transcription; however, this mutation abolished its ability to initiate the viral lytic cascade.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	point	point	NOUN	NN	Number=Sing	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Z	Z	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	S	s	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	186A	186A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	;	;	PUNCT	,	_	_	_	_	_
26	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
30	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
37	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8385
# text = The mutant, containing a serine-to-alanine substitution in the DNA-binding domain of the protein, bound to several known ZEBRA-binding sites and activated transcription from reporters bearing known ZEBRA-responsive promoters but did not disrupt latency in EBV-infected cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alanine	alanine	NOUN	NN	Number=Sing	_	_	_	_
11	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	ZEBRA	zebra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	reporters	reporter	NOUN	NNS	Number=Plur	_	_	_	_
35	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
36	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
40	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	not	not	PART	RB	_	_	_	_	_
44	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
45	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8386
# text = Therefore, initiation of the EBV lytic cycle by the ZEBRA protein requires a function in addition to transcriptional activation; a change of serine 186 to alanine in the DNA-binding domain of ZEBRA abolished this additional function and uncovered a new role for the ZEBRA protein in disruption of EBV latency.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
7	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	change	change	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
26	186	186	NUM	CD	NumType=Card	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	alanine	alanine	NUM	CD	NumType=Card	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
37	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
39	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
40	function	function	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	uncovered	uncover	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
45	role	role	NOUN	NN	Number=Sing	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
49	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
54	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8387
# text = The additional function that is required for initiation of the lytic viral life cycle is likely to require phosphorylation of serine 186 of the ZEBRA protein, which may influence either DNA recognition or transcriptional activation of lytic viral promoters in a chromatinized viral episome.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
13	life	life	NOUN	NN	Number=Sing	_	_	_	_
14	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
22	186	186	NUM	CD	NumType=Card	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
31	either	either	CCONJ	CC	_	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	chromatinized	chromatinize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
45	episome	episome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8388
# text = Document 0030011424 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011424	0030011424	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8389
# text = [An overexpression of retinoic acid receptor alpha blocks myeloid cell differentiation at the promyelocyte stage] Retinoic acid (RA), a vitamin A derivative, exerts a wide range of biological effects related to cell proliferation and differentiation.
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
6	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
10	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	promyelocyte	promyelocyte	ADJ	JJ	Degree=Pos	_	_	_	_
16	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
18	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
19	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
26	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
32	range	range	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
35	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
36	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
39	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8390
# text = The pleiotropic effects of RA are thought to be mediated through specific nuclear RA receptors (RARs).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RARs	RARs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8391
# text = RARs are members of the steroid/thyroid hormone receptor superfamily and exhibit a molecular structure that possess discrete DNA-binding and RA (ligand)-binding domains.
1	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	members	member	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
9	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	superfamily	superfamily	ADV	RB	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	exhibit	exhibit	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	possess	possess	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8392
# text = In hematopoietic system, RA and RARs, predominantly RAR alpha may play key roles for the proliferation and differentiation of hematopoietic progenitors.
1	In	in	ADP	IN	_	_	_	_	_
2	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	RARs	RARs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	predominantly	predominantly	ADV	RB	_	_	_	_	_
10	RAR	Rar	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
14	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
15	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
23	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8393
# text = However, it is currently unknown how RA and RARs are involved in regulating normal hematopoietic differentiation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	currently	currently	ADV	RB	_	_	_	_	_
6	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
7	how	how	ADV	WRB	PronType=Int	_	_	_	_
8	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	RARs	RARs	PROPN	NNPS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8394
# text = To make clear the roles of RA and RAR alpha in the normal hematopoiesis, I have introduced the construct of human RAR alpha (hRAR alpha) into murine bone marrow cells with retroviral vector, and selected infected cells with drug resistant marker (Neo(r)) cultured on the stroma cell line (PA6-neo), and analyzed the behavior of infected cells.
1	To	to	PART	TO	_	_	_	_	_
2	make	make	VERB	VB	VerbForm=Inf	_	_	_	_
3	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
10	alpha	alpha	ADV	RB	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	RAR	RAR	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	hRAR	hrar	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
31	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
32	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	retroviral	retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
36	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
44	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
45	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	Neo	Neo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	r	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	on	on	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	stroma	stroma	NOUN	NN	Number=Sing	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	line	line	NOUN	NN	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	PA6	PA6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	neo	neo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	and	and	CCONJ	CC	_	_	_	_	_
65	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
68	of	of	ADP	IN	_	_	_	_	_
69	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
70	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8395
# text = All of procedure were done in vitro.
1	All	all	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	done	do	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8396
# text = Most cells infected with hRAR alpha exhibited promyelocytic morphology and were thought to be blocked at the promyelocytic stage in their myeloid differentiation.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	hRAR	hrar	PROPN	NNP	Number=Sing	_	_	_	_
6	alpha	alpha	ADV	RB	_	_	_	_	_
7	exhibited	exhibite	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8397
# text = Furthermore, these immature cells differentiated terminally into mature granulocytes by adding with RA (10(-6) M).
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	terminally	terminally	ADV	RB	_	_	_	_	_
8	into	into	ADP	IN	_	_	_	_	_
9	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
10	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	adding	add	VERB	VBG	VerbForm=Ger	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8398
# text = RAR alpha infected cells were also able to differentiate into mature macrophages in the both of long term culture and IL3 colony.
1	RAR	Rar	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	alpha	alpha	ADP	IN	_	_	_	_	_
3	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	term	term	NOUN	NN	Number=Sing	_	_	_	_
19	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL3	IL3	NUM	CD	NumType=Card	_	_	_	_
22	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8399
# text = These observations suggest that an overexpression of RAR alpha alone is effective to suppress myeloid cell differentiation and RAR alpha plays a crucial role in the terminal differentiation of myeloid precursors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	RAR	Rar	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	ADV	RB	_	_	_	_	_
10	alone	alone	ADV	RB	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
15	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	RAR	Rar	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	ADV	RB	_	_	_	_	_
21	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
24	role	role	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
31	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8400
# text = The system described here may serve as a model for studying the the essential genes for differentiation of normal bone marrow cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	system	system	NOUN	NN	Number=Sing	_	_	_	_
3	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	model	model	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	SCONJ	IN	_	_	_	_	_
11	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
21	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8401
# text = Document 0030011426 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011426	0030011426	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8402
# text = Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F.
1	Phosphatidylinositol	Phosphatidylinositol	PROPN	NNP	Number=Sing	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	couples	couple	NOUN	NNS	Number=Plur	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
15	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
16	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8403
# text = Cell cycle progression initiated by interleukin-2 (IL-2) in T cells is critical for lymphoproliferation and an immune response.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
3	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
4	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	lymphoproliferation	lymphoproliferation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8404
# text = Phosphatidyl inositol 3-kinase (PI3K) is activated by IL-2.
1	Phosphatidyl	Phosphatidyl	PROPN	NNP	Number=Sing	_	_	_	_
2	inositol	inositol	NOUN	NN	Number=Sing	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PI3	PI3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8405
# text = However, nuclear targets for PI3K are not known.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	PI3	PI3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	K	k	NUM	CD	NumType=Card	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8406
# text = Here we identify the cell cycle regulator E2F as an IL-2 target in T lymphocytes and PI3K as the critical signaling pathway.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
7	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
8	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	target	target	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	PI3	PI3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	K	k	NUM	CD	NumType=Card	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
24	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8407
# text = We eliminate both Stat5 and Raf/MEK pathways from E2F regulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	eliminate	eliminate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	_
9	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	F	F	PROPN	NNP	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8408
# text = Protein kinase B (PKB) is activated by IL-2 via PI3K.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	B	B	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	PI3K	PI3K	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8409
# text = The expression of an active PKB is sufficient to induce E2F activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
11	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	F	F	PROPN	NNP	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8410
# text = Inhibition of PI3K inhibits phosphorylation of Rb, induction of cyclin D3, and degradation of p27kip1.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PI3	PI3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	K	k	NUM	CD	NumType=Card	_	_	_	_
5	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
13	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	p27kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8411
# text = These results establish a crucial PI3K/PKB-mediated link between the IL-2 teceptor and the cell cycle machinery.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
6	PI3K	Pi3k	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	link	link	NOUN	NN	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	teceptor	teceptor	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
22	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8412
# text = Document 0030011427 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011427	0030011427	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8413
# text = Erythropoietin-dependent induction of hemoglobin synthesis in a cytokine-dependent cell line M-TAT.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	hemoglobin	hemoglobin	ADJ	JJ	Degree=Pos	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	M-	M-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	TAT	TAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8414
# text = M-TAT is a cytokine-dependent cell line with the potential to differentiate along the erythroid and megakaryocytic lineages.
1	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	TAT	Tat	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
16	along	along	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8415
# text = We cultured M-TAT cells long term (>
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	TAT	Tat	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
8	term	term	NOUN	NN	Number=Sing	_	_	_	_
9	(>	(>	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 8416
# text = 1 year) in the continuous presence of erythropoietin (EPO), granulocyte-macrophage colony-stimulating factor (GM-CSF), or stem cell factor (SCF).
1	1	1	NUM	CD	NumType=Card	_	_	_	_
2	year	year	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	erythropoietin	erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
17	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	SCF	SCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8417
# text = These long term cultures are referred to as M-TAT/EPO, M-TAT/GM-CSF, and M-TAT/SCF cells, respectively.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
3	term	term	NOUN	NN	Number=Sing	_	_	_	_
4	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	TAT	TAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	M-	M-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	TAT/GM	TAT/GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	TAT	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	SCF	Scf	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8418
# text = Hemoglobin concentration and gamma-globin and erythroid delta-aminolevulinate synthase mRNA levels were significantly higher in M-TAT/EPO cells than in M-TAT/GM-CSF cells.
1	Hemoglobin	Hemoglobin	ADP	IN	_	_	_	_	_
2	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	delta-	delta-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	aminolevulinate	aminolevulinate	ADJ	JJ	Degree=Pos	_	_	_	_
11	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	TAT	TAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	TAT/GM	TAT/GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8419
# text = When the supplemented cytokine was switched from GM-CSF to EPO, hemoglobin synthesis in M-TAT/GM-CSF cells increased rapidly (within 5 h), and the level of GATA-1 mRNA increased.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	switched	switch	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	hemoglobin	hemoglobin	ADP	IN	_	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	TAT/GM	TAT/GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	rapidly	rapidly	ADV	RB	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	within	within	ADP	IN	_	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	_
27	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
38	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8420
# text = In contrast, the addition of GM-CSF to the M-TAT/EPO cell culture decreased the amount of hemoglobin, even in the presence of EPO, indicating that the EPO signal for erythroid differentiation is suppressed by GM-CSF.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	M-	m-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	TAT	TAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
18	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	even	even	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
35	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8421
# text = Thus, erythroid development of M-TAT cells is promoted by EPO and suppressed by GM-CSF.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	TAT	Tat	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8422
# text = These results support the hypothesis that EPO actively influences the programming of gene expression required for erythroid progenitor cell differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
8	actively	actively	ADV	RB	_	_	_	_	_
9	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	programming	programming	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8423
# text = Document 0030011432 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011432	0030011432	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8424
# text = Transcription factor NF-kappaB regulation of renal fibrosis during ureteral obstruction.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
9	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	ureteral	ureteral	ADJ	JJ	Degree=Pos	_	_	_	_
12	obstruction	obstruction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8425
# text = Irrespective of the etiology, many kidney diseases result in inflammation and fibrosis of the tubulointerstitium, with the subsequent loss of renal function.
1	Irrespective	irrespective	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
7	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
8	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
9	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	tubulointerstitium	tubulointerstitium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
21	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8426
# text = To initiate any disease process or for any disease process to progress, there must be changes in the transcription of genes within the affected tissue.
1	To	to	PART	TO	_	_	_	_	_
2	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
3	any	any	DET	DT	_	_	_	_	_
4	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
5	process	process	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	any	any	DET	DT	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
10	process	process	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	progress	progress	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	there	there	PRON	EX	_	_	_	_	_
15	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	VERB	VB	VerbForm=Inf	_	_	_	_
17	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8427
# text = The nuclear factor-kappa B (NF-kappaB) family of transcription factors regulates genes involved in inflammation, cell proliferation, and cell differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8428
# text = This review discusses the NF-kappaB transcription factor family in general and the association of NF-kappaB activation with cellular/molecular events of renal inflammation and fibrosis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	review	review	NOUN	NN	Number=Sing	_	_	_	_
3	discusses	discuss	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	association	association	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
25	events	event	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
28	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8429
# text = Document 0030011435 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011435	0030011435	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8430
# text = A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	phosphoinositide	phosphoinositide	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8431
# text = BACKGROUND: A delicate balance between positive and negative regulatory mechanisms during T-cell activation determines the specificity and magnitude of an immune response.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	delicate	delicate	ADJ	JJ	Degree=Pos	_	_	_	_
5	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	determines	determine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8432
# text = Phosphoinositide 3-kinase (PI 3-kinase) is activated by a diverse set of receptors that determine T-cell function, including the T-cell antigen receptor (TCR), the costimulatory receptor CD28, and negative regulators of T-cell activation such as CTLA-4.
1	Phosphoinositide	Phosphoinositide	NOUN	NN	Number=Sing	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PI	PI	NUM	CD	NumType=Card	_	_	_	_
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
16	set	set	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	determine	determine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
38	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
42	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
47	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
48	as	as	ADP	IN	_	_	_	_	_
49	CTLA	CTLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8433
# text = PI 3-kinase is also regulated by the haematopoietic cytokines that determine T-cell differentiation and lymphocyte proliferation.
1	PI	PI	NOUN	NN	Number=Sing	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	haematopoietic	haematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	determine	determine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8434
# text = PI 3-kinase can thus dynamically influence the outcome of the immune reactions at various stages.
1	PI	PI	NOUN	NN	Number=Sing	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	thus	thus	ADV	RB	_	_	_	_	_
7	dynamically	dynamically	ADV	RB	_	_	_	_	_
8	influence	influence	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	outcome	outcome	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
14	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
17	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8435
# text = In this study, we investigated the importance of PI 3-kinase in TCR-directed T-cell activation using activated or inhibitory versions of PI 3-kinase.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	PI	pi	NUM	CD	NumType=Card	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
25	versions	version	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8436
# text = RESULTS: Certain aspects of TCR responses such as the induction of transcriptional activity of AP1 and serum response factor were not affected by expression of the mutant forms of PI 3-kinase.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
4	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
7	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
8	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
29	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	PI	pi	NOUN	NN	Number=Sing	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8437
# text = We found, however, that PI 3-kinase profoundly influenced the transactivation capacity of 'nuclear factor of activated T cells' (NF-AT) elicited by the TCR: expression of an activated form of PI 3-kinase inhibited TCR-mediated NF-AT responses, whereas expression of a dominant negative mutant of PI 3-kinase potently enhanced TCR-controlled NF-AT induction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	profoundly	profoundly	ADV	RB	_	_	_	_	_
12	influenced	influence	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	'	'	PUNCT	''	_	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	:	:	PUNCT	:	_	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	form	form	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
42	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
45	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	TCR	TCR	ADV	RB	_	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	AT	at	NOUN	NN	Number=Sing	_	_	_	_
52	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	whereas	whereas	SCONJ	IN	_	_	_	_	_
55	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
58	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
59	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
60	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
63	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
66	potently	potently	ADV	RB	_	_	_	_	_
67	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
68	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
71	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
73	AT	AT	ADJ	JJ	Degree=Pos	_	_	_	_
74	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8438
# text = These effects of PI 3-kinase were not mediated by previously identified PI 3-kinase effectors, such as protein kinase B, a positive regulator of PI 3-kinase, or the GTPase Rac, and are therefore likely to involve a novel, as yet unknown, effector molecule.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PI	pi	PROPN	NNP	Number=Sing	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	previously	previously	ADV	RB	_	_	_	_	_
13	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	PI	PI	NOUN	NN	Number=Sing	_	_	_	_
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	effectors	effector	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
31	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	GTPase	GTPase	PROPN	NNP	Number=Sing	_	_	_	_
38	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
42	therefore	therefore	ADV	RB	_	_	_	_	_
43	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
44	to	to	PART	TO	_	_	_	_	_
45	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	as	as	SCONJ	IN	_	_	_	_	_
50	yet	yet	ADV	RB	_	_	_	_	_
51	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
54	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8439
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 8440
# text = Our results establish that PI 3-kinase can both positively and negatively regulate T-cell function, and uncover a previously unrecognized function for PI 3-kinase in T cells as a selective negative regulator of TCR-signalling events and therefore as a determinant of T-cell homeostasis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	positively	positively	ADV	RB	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	negatively	negatively	ADV	RB	_	_	_	_	_
14	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	uncover	uncover	ADV	RB	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	previously	previously	ADV	RB	_	_	_	_	_
23	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	PI	PI	NUM	CD	NumType=Card	_	_	_	_
27	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
36	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
37	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	signalling	signalling	VERB	VBG	VerbForm=Ger	_	_	_	_
42	events	event	NOUN	NNS	Number=Plur	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	therefore	therefore	ADV	RB	_	_	_	_	_
45	as	as	ADP	IN	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8441
# text = Document 0030011444 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011444	0030011444	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8442
# text = Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8443
# text = Erythropoietin (Epo), the primary regulator of the production of erythroid cells, acts by binding to a cell surface receptor (EpoR) on erythroid progenitors.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
29	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8444
# text = We used deletion analysis and transfection assays with reporter gene constructs to examine the transcription control elements in the 5' flanking region of the human EpoR gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
7	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	``	_	_	_	_	_
22	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	EpoR	Epor	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8445
# text = In erythroid cells most of the transcription activity was contained in a 150 bp promoter fragment with binding sites for transcription factors AP2, Sp1 and the erythroid-specific GATA-1.
1	In	in	ADP	IN	_	_	_	_	_
2	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	150	150	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	SCONJ	IN	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	AP2	AP2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8446
# text = The 150 bp hEpoR promoter exhibited high and low activity in erythroid OCIM1 and K562 cells, respectively, reflecting the high and low levels of constitutive hEpoR expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	150	150	NUM	CD	NumType=Card	_	_	_	_
3	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
4	hEpoR	hepor	CCONJ	CC	_	_	_	_	_
5	promoter	promoter	ADV	RB	_	_	_	_	_
6	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	erythroid	erythroid	PROPN	NNP	Number=Sing	_	_	_	_
13	OCIM1	OCIM1	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	K562	K562	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	reflecting	reflect	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
28	hEpoR	hepor	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8447
# text = The GATA-1 and Sp1 binding sites in this promoter lacking a TATA sequence were necessary for a high level of transcription activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8448
# text = Protein-DNA binding studies suggested that Sp1 and two other CCGCCC binding proteins from erythroid and non-erythroid cells could bind to the Sp1 binding motif.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	CCGCCC	Ccgccc	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
21	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8449
# text = By increasing GATA-1 levels via co-transfection, we were able to transactivate the hEpoR promoter in K562 cells and non-erythroid cells, but not in the highly active OCIM1 cells, although GATA-1 mRNA levels were comparable in OCIM1 and K562.
1	By	by	SCONJ	IN	_	_	_	_	_
2	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	via	via	ADP	IN	_	_	_	_	_
8	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	hEpoR	hepor	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	K562	K562	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	highly	highly	ADV	RB	_	_	_	_	_
30	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
31	OCIM1	Ocim1	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	although	although	SCONJ	IN	_	_	_	_	_
35	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	OCIM1	Ocim1	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	K562	k562	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8450
# text = Interestingly, when we mutated the Sp1 site, resulting in a marked decrease in hEpoR promoter activity, we could restore transactivation by increasing GATA-1 levels in OCIM1 cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	mutated	mutate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	hEpoR	hepor	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
22	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
23	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	SCONJ	IN	_	_	_	_	_
25	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
26	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	OCIM1	OCIM1	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8451
# text = These data suggest that while GATA-1 can transactivate the EpoR promoter, the level of hEpoR gene expression does not depend on GATA-1 alone.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	while	while	SCONJ	IN	_	_	_	_	_
6	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	hEpoR	hepor	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	_
28	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8452
# text = Rather, hEpoR transcription activity depends on coordination between Sp1 and GATA-1 with other cell-specific factors, including possibly other Sp1-like binding proteins, to provide high level, tissue-specific expression.
1	Rather	Rather	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	hEpoR	hepor	CCONJ	CC	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	possibly	possibly	ADV	RB	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	like	like	SCONJ	IN	_	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
33	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8453
# text = Document 0030011445 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011445	0030011445	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8454
# text = Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes.
1	Alcohol	alcohol	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8455
# text = Acute ethanol exposure has the capacity to modulate immune functions, particularly, to down regulate monocyte production of inflammatory cytokines.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	ethanol	ethanol	ADJ	JJ	Degree=Pos	_	_	_	_
3	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	particularly	particularly	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	down	down	ADV	RB	_	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8456
# text = However, the intracellular mechanisms for these effects of ethanol are yet to be understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	ethanol	ethanol	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	yet	yet	ADV	RB	_	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8457
# text = Considering that nuclear regulatory factor-kappa beta (NF-kappa B)/Rel is a common regulatory element of the promoter region of the inflammatory cytokine genes, herein, we tested the hypothesis that acute ethanol affects NF-kappa B activation in human monocytes.
1	Considering	consider	VERB	VBG	VerbForm=Ger	_	_	_	_
2	that	that	SCONJ	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	herein	herein	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
35	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	acute	acute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	ethanol	ethanol	ADJ	JJ	Degree=Pos	_	_	_	_
41	affects	affect	NOUN	NNS	Number=Plur	_	_	_	_
42	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
49	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8458
# text = Adherence-isolated monocytes showed constitutive DNA binding activity of NF-kappa B.
1	Adherence	Adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8459
# text = A clinically relevant dose (25 mM) of acute ethanol treatment in vitro increased NF-kappa B binding activity in monocytes with a preferential induction of the inhibitory, p50/p50, NF-kappa B/Rel homodimer, and resulted in no induction of the p65/p50 heterodimer.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	clinically	clinically	ADV	RB	_	_	_	_	_
3	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
4	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	25	25	NUM	CD	NumType=Card	_	_	_	_
7	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	ethanol	ethanol	ADJ	JJ	Degree=Pos	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	preferential	preferential	ADJ	JJ	Degree=Pos	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
42	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	no	no	DET	DT	_	_	_	_	_
48	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	p65/	p65/	SYM	SYM	_	_	_	_	SpaceAfter=No
52	p50	p50	NUM	CD	NumType=Card	_	_	_	_
53	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8460
# text = In contrast, lipopolysaccharide stimulation primarily induced the p65/p50 heterodimer that has been shown to result in gene activation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	primarily	primarily	ADV	RB	_	_	_	_	_
7	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	_
12	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8461
# text = Thus, such unique activation of the inhibitory p50/p50 homodimer by acute ethanol treatment may result in inhibition rather than activation of NF-kappa B-regulated inflammatory cytokine genes.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
4	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
9	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	_
12	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	ethanol	ethanol	ADJ	JJ	Degree=Pos	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	rather	rather	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8462
# text = Consequently, these results suggest that physiologically relevant concentrations of ethanol may affect production of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 by disrupting NF-kappa B signaling in monocytes.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	physiologically	physiologically	ADV	RB	_	_	_	_	_
8	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	ethanol	ethanol	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	by	by	SCONJ	IN	_	_	_	_	_
36	disrupting	disrupting	VERB	VBG	VerbForm=Ger	_	_	_	_
37	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8463
# text = Document 0030011448 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011448	0030011448	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8464
# text = Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression.
1	Cloning	Clon	VERB	VBG	VerbForm=Ger	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8465
# text = Early B-cell factor (EBF) was identified previously as a tissue-specific and differentiation stage-specific DNA-binding protein that participates in the regulation of the pre-B and B lymphocyte-specific mb-1 gene.
1	Early	Early	ADJ	JJ	Degree=Pos	_	_	_	_
2	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	participates	participate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
34	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
37	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	mb	mb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-1	-1	NUM	CD	NumType=Card	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8466
# text = Partial amino acid sequences obtained from purified EBF were used to isolate cDNA clones, which by multiple criteria encode EBF.
1	Partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
2	amino	amino	DET	DT	_	_	_	_	_
3	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
13	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
14	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	criteria	criteria	NOUN	NN	Number=Sing	_	_	_	_
20	encode	encode	ADP	IN	_	_	_	_	_
21	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8467
# text = The recombinant polypeptide formed sequence-specific complexes with the EBF-binding site in the mb-1 promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
3	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
4	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	EBF	Ebf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	mb	mb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8468
# text = The cDNA hybridized to multiple transcripts in pre-B and B-cell lines, but transcripts were not detected at significant levels in plasmacytoma, T-cell, and nonlymphoid cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNA	NOUN	NN	Number=Sing	_	_	_	_
3	hybridized	hybridize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	pre	pre	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-B	-b	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8469
# text = Expression of recombinant EBF in transfected nonlymphoid cells strongly activated transcription from reporter plasmids containing functional EBF-binding sites.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
4	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	strongly	strongly	ADV	RB	_	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
15	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
16	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
17	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8470
# text = Analysis of DNA binding by deletion mutants of EBF identified an amino-terminal cysteine-rich DNA-binding domain lacking obvious sequence similarity to known transcription factors.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
7	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
10	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	amino-terminal	amino-terminal	ADJ	JJ	Degree=Pos	_	_	_	_
13	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
21	obvious	obvious	ADJ	JJ	Degree=Pos	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8471
# text = DNA-binding assays with cotranslated wild-type and truncated forms of EBF indicated that the protein interacts with its site as a homodimer.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	cotranslated	cotranslate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
14	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8472
# text = Deletions delineated a carboxy-terminal dimerization region containing two repeats of 15 amino acids that show similarity with the dimerization domains of basic-helix-loop-helix proteins.
1	Deletions	Deletion	NOUN	NNS	Number=Plur	_	_	_	_
2	delineated	delineate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
7	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	15	15	NUM	CD	NumType=Card	_	_	_	_
14	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
15	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	basic-helix-loop	basic-helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-helix	-helix	NOUN	NN	Number=Sing	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8473
# text = Together, these data suggest that EBF represents a novel regulator of B lymphocyte-specific gene expression.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
8	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
11	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8474
# text = Document 0030011454 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011454	0030011454	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8475
# text = Signal transduction pathways triggered by the FcepsilonRIIb receptor (CD23) in human monocytes lead to nuclear factor-kappaB activation.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	FcepsilonRIIb	FcepsilonRIIb	PROPN	NNP	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8476
# text = BACKGROUND: Alveolar macrophages play a key role in the initiation of the inflammatory reaction of allergic asthma.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Alveolar	Alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
4	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
5	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
18	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8477
# text = Alveolar macrophages and peripheral blood monocytes are activated when IgE/allergen immune complexes bind to the CD23 receptor, which leads to the production of inflammatory cytokines.
1	Alveolar	Alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
2	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	allergen	allergen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	immune	immune	PRON	PRP	_	_	_	_	_
14	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
15	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8478
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 8479
# text = We sought to investigate the molecular mechanisms regulating this early inflammatory response.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8480
# text = We have focused on the study of the signal transduction pathways triggered by CD23 in human monocytes and the promonocytic cell line U937.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
12	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	_
23	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8481
# text = METHODS: CD23 was cross-linked in human monocytes and U937 cells with IgE immune complexes.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	cross	cross	ADV	RB	_	_	_	_	SpaceAfter=No
6	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	_
15	immune	immune	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8482
# text = Surface expression of CD23 was determined by FACS analysis.
1	Surface	surface	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	FACS	FACS	ADJ	JJ	Degree=Pos	_	_	_	_
9	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8483
# text = Transcription factor activation and gene transcription were studied by gel-shift assays and Northern blot analysis, respectively.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
13	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
16	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
17	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8484
# text = IkappaBalpha phosphorylation and degradation was analyzed by Western blot.
1	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
9	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8485
# text = RESULTS: Nuclear factor (NF)-kappaB is the main transcription factor involved in the gene activation that follows CD23 cross-linking in monocytes.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	follows	follow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
23	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8486
# text = CD23-induced NF-kappaB is a heterodimer composed of p65/p50 subunits.
1	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
9	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	p65/	p65/	SYM	SYM	_	_	_	_	SpaceAfter=No
12	p50	p50	NUM	CD	NumType=Card	_	_	_	_
13	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8487
# text = NF-kappaB nuclear translocation is secondary to the phosphorylation and subsequent degradation of the NF-kappaB inhibitory molecule IkappaBalpha.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
13	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
20	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
21	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8488
# text = Tyrosine kinase-dependent, and not protein kinase C-dependent, pathways mediate CD23-triggered NF-kappaB activation but do not participate in the direct phosphorylation of IkappaBalpha.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	CD23	CD23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8489
# text = IkappaBalpha degradation and NF-kappaB nuclear translocation correlate with transcriptional activation of the inflammatory cytokines TNF-alpha and IL-1beta.
1	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
17	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8490
# text = CONCLUSIONS: NF-kappaB is the main transcription factor involved in the signal transduction pathway of CD23 in monocytes.
1	CONCLUSIONS	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8491
# text = Document 0030011455 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011455	0030011455	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8492
# text = Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
12	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
19	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
22	lpr	lpr	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	gld	gld	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8493
# text = We previously identified a Fas ligand regulatory element (FLRE) in the Fas ligand (fasL) promoter that binds
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	Fas	Fas	PROPN	NNPS	Number=Plur	_	_	_	_
6	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FLRE	FLRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Fas	Fas	PROPN	NNPS	Number=Plur	_	_	_	_
15	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	fasL	fasL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_

# sent_id = 8494
# text = Egr family proteins and demonstrated that Egr-3 (PILOT) but not Egr-1 (NGFI-A, Krox-24, Tis-8, and Zif-268) induces transcription of fasL.
1	Egr	Egr	ADJ	JJ	Degree=Pos	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-3	-3	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PILOT	Pilot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	Egr	Egr	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NGFI	Ngfi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Krox	Krox	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	24	24	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Tis	tis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Zif	Zif	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	268	268	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	fasL	fasL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8495
# text = The aberrant CD4(-)CD8(-)
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aberrant	aberrant	NOUN	NN	Number=Sing	_	_	_	_
3	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
6	CD8	Cd8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	(-)	(-)	PUNCT	.	_	_	_	_	_

# sent_id = 8496
# text = T cells from lpr/lpr and gld/gld mice, which have mutations in the genes encoding Fas and FasL, respectively, have an activated phenotype and constitutively express high levels of fasL mRNA, prompting us to ask what role if any the FLRE and Egr family proteins have in this aberrant expression of fasL.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	lpr/	lpr/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
5	lpr	lpr	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	gld	gld	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	gld	gld	NOUN	NN	Number=Sing	_	_	_	_
10	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
19	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	constitutively	constitutively	ADV	RB	_	_	_	_	_
31	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
33	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	fasL	fasL	PROPN	NNP	Number=Sing	_	_	_	_
36	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	prompting	prompt	VERB	VBG	VerbForm=Ger	_	_	_	_
39	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	ask	ask	VERB	VB	VerbForm=Inf	_	_	_	_
42	what	what	DET	WDT	PronType=Int	_	_	_	_
43	role	role	NOUN	NN	Number=Sing	_	_	_	_
44	if	if	SCONJ	IN	_	_	_	_	_
45	any	any	DET	DT	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	FLRE	Flre	ADJ	JJ	Degree=Pos	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	Egr	Egr	ADJ	JJ	Degree=Pos	_	_	_	_
50	family	family	NOUN	NN	Number=Sing	_	_	_	_
51	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
52	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
55	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	fasL	fasL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8497
# text = Unstimulated MRL-lpr/lpr and C3H-gld/gld CD4(-)CD8(-)
1	Unstimulated	Unstimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	MRL	Mrl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	lpr	lpr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	lpr	lpr	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	C3H-gld/gld	C3H-gld/gld	PROPN	NNP	Number=Sing	_	_	_	_
9	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(-)	(-)	PUNCT	.	_	_	_	_	SpaceAfter=No
11	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(-)	(-)	PUNCT	.	_	_	_	_	_

# sent_id = 8498
# text = T cells constitutively contained high levels of two proteins that bound to the FLRE.
1	T	t	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	constitutively	constitutively	ADV	RB	_	_	_	_	_
4	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	FLRE	Flre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8499
# text = Supershift analysis revealed these proteins to be Egr-1 and Egr-2 (Krox-20); Egr-3 was not detected.
1	Supershift	Supershift	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	analysis	analysis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-1	-1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-2	-2	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Krox	Krox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-3	-3	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8500
# text = Activation of normal lymph node cells resulted in increased expression of Egr-1, -2, and -3.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
5	node	node	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8501
# text = As with egr-3, expression of egr-2 was blocked by cyclosporin A.
1	As	as	ADP	IN	_	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-2	-2	NUM	CD	NumType=Card	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8502
# text = Although overexpressed Egr-1 was ineffective, overexpressed Egr-2 was as potent as Egr-3 in inducing fasL promoter-dependent reporter constructs in T cell hybridomas and HeLa cells, and both up-regulated endogenous fasL mRNA in HeLa cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	ineffective	ineffective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	overexpressed	overexpress	ADJ	JJ	Degree=Pos	_	_	_	_
9	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-3	-3	NUM	CD	NumType=Card	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
20	fasL	fasl	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
25	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
29	hybridomas	hybridoma	PROPN	NNPS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	both	both	ADV	RB	_	_	_	_	_
36	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
40	fasL	fasL	PROPN	NNP	Number=Sing	_	_	_	_
41	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8503
# text = FasL-dependent reporter constructs in MRL-lpr/lpr and C3H-gld/gld CD4(-)CD8(-)
1	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	MRL	MRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	lpr/lpr	lpr/lpr	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	C3H-gld/	C3H-gld/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	gld	gld	NOUN	NN	Number=Sing	_	_	_	_
13	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(-)	(-)	PUNCT	.	_	_	_	_	SpaceAfter=No
15	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(-)	(-)	PUNCT	.	_	_	_	_	_

# sent_id = 8504
# text = T cells were constitutively active, and this activity was largely prevented by mutation of the critical Egr family binding element.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	largely	largely	ADV	RB	_	_	_	_	_
12	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8505
# text = Thus, Egr-2, in addition to Egr-3, regulates FasL expression in activated normal T cells, and Egr-2 is likely to play a direct role in aberrant fasL up-regulation in lpr/lpr and gld/gld CD4(-)CD8(-) T cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
34	fasL	fasL	NOUN	NN	Number=Sing	_	_	_	_
35	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	lpr/lpr	lpr/lpr	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	gld/gld	gld/gld	ADJ	JJ	Degree=Pos	_	_	_	_
42	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	(-)	(-)	PUNCT	.	_	_	_	_	SpaceAfter=No
44	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	-)	-)	PUNCT	.	_	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8506
# text = Document 0030011458 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011458	0030011458	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8507
# text = Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	TAFII	TAFII	NOUN	NN	Number=Sing	_	_	_	_
3	105	105	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	hTAFII130	hTAFII130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8508
# text = We previously characterized Drosophila and human TAF subunits that make up the core TFIID complex found in all cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	TAF	Taf	NOUN	NN	Number=Sing	_	_	_	_
8	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	make	make	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	up	up	ADP	RP	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	core	core	NOUN	NN	Number=Sing	_	_	_	_
14	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	all	all	DET	DT	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8509
# text = Here, we report that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated with TFIID isolated from other cell types.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	differentiated	differentiate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	substoichiometric	substoichiometric	ADJ	JJ	Degree=Pos	_	_	_	_
13	TAF	Taf	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	105	105	NUM	CD	NumType=Card	_	_	_	_
16	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	TFIID	tFIId	PROPN	NNP	Number=Sing	_	_	_	_
22	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8510
# text = The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110, while the N-terminal coactivator domain has diverged significantly.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
4	hTAFII105	hTAFII105	NUM	CD	NumType=Card	_	_	_	_
5	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	highly	highly	ADV	RB	_	_	_	_	_
8	conserved	conserved	ADJ	JJ	Degree=Pos	_	_	_	_
9	C-	C-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	hTAFII130	hTAFII130	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	oTAFII110	oTAFII110	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	diverged	diverge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	significantly	significantly	ADV	RB	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8511
# text = All cells tested express TAFII105 mRNA, but only B cells contain significant levels of protein associated with TFIID.
1	All	all	DET	DT	_	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
5	TAFII105	TAFII105	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8512
# text = Transient overexpression of hTAFII105 selectively squelches the transcription of some genes in B cells.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hTAFII105	hTAFII105	PROPN	NNP	Number=Sing	_	_	_	_
5	selectively	selectively	ADV	RB	_	_	_	_	_
6	squelches	squelch	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	some	some	DET	DT	_	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8513
# text = These properties suggest that TAFII105 is a cell type-specific subunit of TFIID that may be responsible for mediating transcription by a subset of activators in B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TAFII105	TAFII105	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8514
# text = Document 0030011461 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011461	0030011461	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8515
# text = CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.
1	CNI	Cni	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1493	1493	NUM	CD	NumType=Card	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
15	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8516
# text = Tumor necrosis factor (TNF) mediates a wide variety of disease states including septic shock, acute and chronic inflammation, and cachexia.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
10	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
13	states	state	NOUN	NNS	Number=Plur	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
16	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
21	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	cachexia	cachexia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8517
# text = Recently, a multivalent guanylhydrazone (CNI-1493) developed as an inhibitor of macrophage activation was shown to suppress TNF production and protect against tissue inflammation and endotoxin lethality [Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimmerman, G.A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B., Manogue, K.R., Tortolani, A.J., Cerami, A.& Tracey, K.J.(1995) Mol.Med.1, 254-266, and Bianchi, M., Bloom, O., Raabe, T., Cohen, P. S., Chesney, J., Sherry, B., Schmidtmayerova, H., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A.& Tracey, J.(1996) J.Exp.Med., in press].
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	multivalent	multivalent	ADJ	JJ	Degree=Pos	_	_	_	_
5	guanylhydrazone	guanylhydrazone	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	CNI	Cni	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	1493	1493	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
22	TNF	TNF	ADP	RP	_	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
26	against	against	ADP	IN	_	_	_	_	_
27	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
28	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
31	lethality	lethality	NOUN	NN	Number=Sing	_	_	_	_
32	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	Bianchi	Bianchi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	M.	M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	Ulrich	Ulrich	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	P.	P.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	Bloom	Bloom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	O.	O.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	Meistrell	Meistrell	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	M.	M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	Zimmerman	Zimmerman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	G.	G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	A.	A.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	Schmidtmayerova	Schmidtmayerova	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	H.	H.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	Bukrinsky	Bukrinsky	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	M.	M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	Donnelley	Donnelley	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	T.	T.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	,	,	PUNCT	,	_	_	_	_	_
66	Bucala	Bucala	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	R.	R.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	Sherry	Sherry	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	,	,	PUNCT	,	_	_	_	_	_
72	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
73	,	,	PUNCT	,	_	_	_	_	_
74	Manogue	Manogue	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	K.R.	K.R.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	,	,	PUNCT	,	_	_	_	_	_
78	Tortolani	Tortolani	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	,	,	PUNCT	,	_	_	_	_	_
80	A.J.	A.J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
81	,	,	PUNCT	,	_	_	_	_	_
82	Cerami	Cerami	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
83	,	,	PUNCT	,	_	_	_	_	_
84	A.	A.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
85	&	&	CCONJ	CC	_	_	_	_	_
86	Tracey	Tracey	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
87	,	,	PUNCT	,	_	_	_	_	_
88	K.J.	K.J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
89	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
90	1995	1995	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
91	)	)	PUNCT	-RRB-	_	_	_	_	_
92	Mol.Med	Mol.Med	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
93	.1	.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
94	,	,	PUNCT	,	_	_	_	_	_
95	254	254	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
96	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
97	266	266	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
98	,	,	PUNCT	,	_	_	_	_	_
99	and	and	CCONJ	CC	_	_	_	_	_
100	Bianchi	Bianchi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
101	,	,	PUNCT	,	_	_	_	_	_
102	M.	M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
103	,	,	PUNCT	,	_	_	_	_	_
104	Bloom	Bloom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
105	,	,	PUNCT	,	_	_	_	_	_
106	O.	O.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
107	,	,	PUNCT	,	_	_	_	_	_
108	Raabe	Raabe	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
109	,	,	PUNCT	,	_	_	_	_	_
110	T.	T.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
111	,	,	PUNCT	,	_	_	_	_	_
112	Cohen	Cohen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
113	,	,	PUNCT	,	_	_	_	_	_
114	P.	P.	PROPN	NNP	Number=Sing	_	_	_	_
115	S.	S.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
116	,	,	PUNCT	,	_	_	_	_	_
117	Chesney	Chesney	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
118	,	,	PUNCT	,	_	_	_	_	_
119	J.	j.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
120	,	,	PUNCT	,	_	_	_	_	_
121	Sherry	Sherry	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
122	,	,	PUNCT	,	_	_	_	_	_
123	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
124	,	,	PUNCT	,	_	_	_	_	_
125	Schmidtmayerova	Schmidtmayerova	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
126	,	,	PUNCT	,	_	_	_	_	_
127	H.	H.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
128	,	,	PUNCT	,	_	_	_	_	_
129	Zhang	Zhang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
130	,	,	PUNCT	,	_	_	_	_	_
131	X.	X.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
132	,	,	PUNCT	,	_	_	_	_	_
133	Bukrinsky	Bukrinsky	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
134	,	,	PUNCT	,	_	_	_	_	_
135	M.	M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
136	,	,	PUNCT	,	_	_	_	_	_
137	Ulrich	Ulrich	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
138	,	,	PUNCT	,	_	_	_	_	_
139	P.	P.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
140	,	,	PUNCT	,	_	_	_	_	_
141	Cerami	Cerami	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
142	,	,	PUNCT	,	_	_	_	_	_
143	A.	A.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
144	&	&	CCONJ	CC	_	_	_	_	_
145	Tracey	Tracey	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
146	,	,	PUNCT	,	_	_	_	_	_
147	J.	j.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
148	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
149	1996	1996	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
150	)	)	PUNCT	-RRB-	_	_	_	_	_
151	J.Exp.Med	J.Exp.Med	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
152	.	.	PUNCT	.	_	_	_	_	SpaceAfter=No
153	,	,	PUNCT	,	_	_	_	_	_
154	in	in	ADP	IN	_	_	_	_	_
155	press	press	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
156	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
157	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8518
# text = We have now elucidated the mechanism by which CNI-1493 inhibits macrophage TNF synthesis and show here that it acts through suppression of TNF translation efficiency.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	CNI	CNI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	1493	1493	NUM	CD	NumType=Card	_	_	_	_
12	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
15	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
18	here	here	ADV	RB	PronType=Dem	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
26	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
27	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8519
# text = CNI-1493 blocked neither the lipopolysaccharide (LPS)-induced increases in the expression of TNF mRNA nor the translocation of nuclear factor NF-kappa B to the nucleus in macrophages activated by 15 min of LPS stimulation, indicating that CNI-1493 does not interfere with early NF-kappa B-mediated transcriptional regulation of TNF.
1	CNI	CNI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1493	1493	NUM	CD	NumType=Card	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	neither	neither	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
19	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
20	nor	nor	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
35	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	15	15	NUM	CD	NumType=Card	_	_	_	_
38	min	min	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
41	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
44	that	that	SCONJ	IN	_	_	_	_	_
45	CNI	CNI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	1493	1493	NUM	CD	NumType=Card	_	_	_	_
48	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	not	not	PART	RB	_	_	_	_	_
50	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
53	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
56	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
60	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8520
# text = However, synthesis of the 26-kDa membrane form of TNF was effectively blocked by CNI-1493.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
10	form	form	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	effectively	effectively	ADV	RB	_	_	_	_	_
15	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	CNI	CNI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-1493	-1493	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8521
# text = Further evidence for the translational suppression of TNF is given by experiments using chloram-phenicol acetyltransferase (CAT) constructs containing elements of the TNF gene that are involved in TNF translational regulation.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
6	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	given	give	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	chloram	chloram	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	phenicol	phenicol	NOUN	NN	Number=Sing	_	_	_	_
17	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
33	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
34	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8522
# text = Both the 5' and 3' untranslated regions of the TNF gene were required to elicit maximal translational suppression by CNI-1493.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	3	3	X	LS	_	_	_	_	SpaceAfter=No
7	'	'	PUNCT	``	_	_	_	_	_
8	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
9	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	elicit	elicit	VERB	VB	VerbForm=Inf	_	_	_	_
18	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
19	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
20	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	CNI	CNI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-1493	-1493	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8523
# text = Identification of the molecular target through which CNI- 1493 inhibits TNF translation should provide insight into the regulation of macrophage activation and mechanisms of inflammation.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	target	target	NOUN	NN	Number=Sing	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	CNI	CNI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	_
10	1493	1493	NUM	CD	NumType=Card	_	_	_	_
11	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
12	TNF	Tnf	ADP	IN	_	_	_	_	_
13	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
14	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	insight	insight	ADV	RB	_	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8524
# text = Document 0030011465 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011465	0030011465	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8525
# text = Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells.
1	Cortivazol	Cortivazol	PROPN	NNP	Number=Sing	_	_	_	_
2	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	messenger	messenger	ADV	RBR	_	_	_	_	_
8	ribonucleic	ribonucleic	ADJ	JJ	Degree=Pos	_	_	_	_
9	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukemic	leukemic	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8526
# text = Cortivazol is a phenylpyrazolo glucocorticoid of high potency and unusual structure.
1	Cortivazol	Cortivazol	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	phenylpyrazolo	phenylpyrazolo	NOUN	NN	Number=Sing	_	_	_	_
5	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	unusual	unusual	ADJ	JJ	Degree=Pos	_	_	_	_
11	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8527
# text = In both wild-type and highly dexamethasone(dex)-resistant clones of the human leukemic cell line CEM, exposure to cortivazol leads to cell death.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	highly	highly	ADV	RB	_	_	_	_	_
8	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	dex	dex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
14	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	cortivazol	cortivazol	VERB	VB	VerbForm=Inf	_	_	_	_
26	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
29	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8528
# text = It has been shown recently that in wild-type CEM cells but not in a dex-resistant, glucocorticoid receptor(GR)-defective clone ICR-27 TK-3, dex induces GR mRNA.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	recently	recently	ADV	RB	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	dex	dex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-resistant	-resistant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
27	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
28	ICR	Icr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	27	27	NUM	CD	NumType=Card	_	_	_	_
31	TK	TK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	dex	dex	NOUN	NN	Number=Sing	_	_	_	_
36	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
37	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
38	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8529
# text = To test the hypothesis that cortivazol acts in dex-resistant cells by making use of the residual GR found there, wild-type and dex-resistant clones were treated with various concentrations of cortivazol and induction of GR mRNA was studied.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	cortivazol	cortivazol	ADJ	JJ	Degree=Pos	_	_	_	_
7	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	making	make	VERB	VBG	VerbForm=Ger	_	_	_	_
13	use	use	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	residual	residual	ADJ	JJ	Degree=Pos	_	_	_	_
17	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
18	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	there	there	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
26	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
31	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	cortivazol	cortivazol	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
38	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8530
# text = Cortivazol significantly induced GR mRNA in the normal CEM-C7 as well as in two classes of dex-resistant clones, although the dex-resistant clones needed at least 10 times more cortivazol than the normal cells for significant GR mRNA induction.
1	Cortivazol	Cortivazol	PROPN	NNP	Number=Sing	_	_	_	_
2	significantly	significantly	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	CEM	cem	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	C7	C7	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
20	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	although	although	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
25	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
26	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	ADV	RB	_	_	_	_	_
28	least	least	ADV	RBS	Degree=Sup	_	_	_	_
29	10	10	NUM	CD	NumType=Card	_	_	_	_
30	times	time	NOUN	NNS	Number=Plur	_	_	_	_
31	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
32	cortivazol	cortivazol	NOUN	NN	Number=Sing	_	_	_	_
33	than	than	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
39	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
40	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
41	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8531
# text = Increased levels of GR mRNA were noticed as early as 3 h after treatment.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	noticed	notice	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	as	as	ADV	RB	_	_	_	_	_
9	early	early	ADV	RB	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8532
# text = A general correlation between induction of GR mRNA and lysis of the normal and dex-resistant cells was found.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	dex	dex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8533
# text = Positive induction of GR mRNA might be one of the earliest crucial steps in the lysis of normal and dex-resistant CEM cells, or might serve as a marker for the process.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
12	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
13	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	dex-resistant	dex-resistant	ADJ	JJ	Degree=Pos	_	_	_	_
21	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
26	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8534
# text = However, the lysis pathway in the dex-resistant cells is defective in that dex-resistant clones needed significantly more cortivazol than the normal cells for lysis of the cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	dex-	dex-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	dex-	dex-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
17	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
18	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	cortivazol	cortivazol	ADJ	JJ	Degree=Pos	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8535
# text = Document 0030011473 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011473	0030011473	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8536
# text = Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PILOT	Pilot	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	cyclosporin	cyclosporin	VERB	VB	VerbForm=Inf	_	_	_	_
16	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	sensitive	sensitive	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8537
# text = Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).
1	Few	few	ADJ	JJ	Degree=Pos	_	_	_	_
2	known	know	ADJ	JJ	Degree=Pos	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	8	8	NUM	CD	NumType=Card	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
33	myristic	myristic	ADJ	JJ	Degree=Pos	_	_	_	_
34	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	only	only	ADV	RB	_	_	_	_	_
51	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
52	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
53	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
54	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
55	fully	fully	ADV	RB	_	_	_	_	_
56	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
59	A	A	PROPN	NNP	Number=Sing	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8538
# text = We have identified a putative transcription factor, designated PILOT, with an identical dual signal requirement for expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	PILOT	Pilot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
15	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8539
# text = Induction of the PILOT gene is detectable in human T cells 20 min following activation in the presence of cycloheximide and is fully suppressed by CyA.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PI	PI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	LOT	lot	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	20	20	NUM	CD	NumType=Card	_	_	_	_
14	min	min	NOUN	NNS	Number=Plur	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	fully	fully	ADV	RB	_	_	_	_	_
25	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8540
# text = The PILOT protein has a calculated M(r) of 42.6 kDa and contains three zinc fingers of the C2H2-type at the carboxyl-terminus which are highly homologous to the zinc finger regions of the transcription factors EGR1, EGR2, and pAT 133.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	PI	pi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	LOT	Lot	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	calculated	calculate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	r	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	42.6	42.6	NUM	CD	NumType=Card	_	_	_	_
14	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	three	three	NUM	CD	NumType=Card	_	_	_	_
18	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
19	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	C2	C2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	highly	highly	ADV	RB	_	_	_	_	_
34	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
38	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
39	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
43	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
44	EGR1	EGR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	EGR2	EGR2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	pAT	pAT	NOUN	NN	Number=Sing	_	_	_	_
50	133	133	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8541
# text = In contrast to T cells, in fibroblasts PILOT gene expression requires only one signal (PMA) and is not affected by CyA.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
9	PI	PI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	LOT	LOT	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8542
# text = This observation directly demonstrates the existence of a Ca2+ signal-dependent regulatory element obligatory for expression of some genes in T cells but not in fibroblasts.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	directly	directly	ADV	RB	_	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	obligatory	obligatory	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8543
# text = This differential expression model will be valuable in the dissection of the dual signal pathway in T cells and the effects of CyA upon it.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	valuable	valuable	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	CyA	CyA	PROPN	NNP	Number=Sing	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8544
# text = Document 0030011481 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011481	0030011481	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8545
# text = Expression and genomic configuration of GM-CSF, IL-3, M-CSF receptor (C-FMS), early growth response gene-1 (EGR-1) and M-CSF genes in primary myelodysplastic syndromes.
1	Expression	expression	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
4	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	FMS	FMS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
24	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	EGR	EGR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
41	myelodysplastic	myelodysplastic	ADJ	JJ	Degree=Pos	_	_	_	_
42	syndromes	syndrome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8546
# text = Peripheral blood mononuclear cells from seventeen patients with primary myelodysplastic syndromes (MDS) in advanced stage were enriched for blasts and tested for (1) karyotype, (2) genomic configuration and (3) expression of IL-3, GM-CSF, FMS and EGR-1 genes which are all located on the long arm of chromosome 5.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	seventeen	seventeen	NUM	CD	NumType=Card	_	_	_	_
7	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	myelodysplastic	myelodysplastic	ADJ	JJ	Degree=Pos	_	_	_	_
11	syndromes	syndrome	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MDS	MDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
17	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	1	1	X	LS	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	karyotype	karyotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	2	2	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
34	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	3	3	X	LS	_	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	FMS	FMS	PROPN	NNP	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
55	which	which	PRON	WDT	PronType=Rel	_	_	_	_
56	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
57	all	all	ADV	RB	_	_	_	_	_
58	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	on	on	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
62	arm	arm	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
65	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8547
# text = The expression of the M-CSF gene, that has been recently reassigned to the short arm of chromosome 1 (lp), was also investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	recently	recently	ADV	RB	_	_	_	_	_
14	reassigned	reassign	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
18	arm	arm	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	lp	lp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	also	also	ADV	RB	_	_	_	_	_
28	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8548
# text = Aims of the study were to (1) assess the potential role of the expression of these genes in the maintenance and expansion of the neoplastic clones and (2) search for constitutional losses or rearrangements of one allele followed by a deletion of the second allele of the same genes in the leukemic cells.
1	Aims	aim	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	1	1	X	LS	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
28	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	2	2	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	search	search	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	constitutional	constitutional	ADJ	JJ	Degree=Pos	_	_	_	_
36	losses	loss	NOUN	NNS	Number=Plur	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	one	one	NUM	CD	NumType=Card	_	_	_	_
41	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
42	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
49	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
53	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8549
# text = The latter issue was investigated by comparing, in 8 cases, constitutive DNA from skin fibroblasts with leukemic DNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
3	issue	issue	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	comparing	comparing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
17	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8550
# text = Eleven of the 17 patients had abnormal karyotypes.
1	Eleven	eleven	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	17	17	NUM	CD	NumType=Card	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
6	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
8	karyotypes	karyotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8551
# text = The M-CSF gene was expressed in 6 cases and the FMS and the EGR-1 genes were expressed in 2 of the latter cases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	FMS	Fm	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
27	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8552
# text = An autocrine mechanism of growth could be hypothesized only for the 2 patients whose cells expressed both the M-CSF and FMS genes.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	hypothesized	hypothesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	FMS	FMS	ADJ	JJ	Degree=Pos	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8553
# text = No germline changes or rearrangements were observed in any of the genes studied.
1	No	no	DET	DT	_	_	_	_	_
2	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	any	any	DET	DT	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8554
# text = Thus, deregulation of genes encoding for certain hemopoietic growth factors or receptors does not seem to represent a major mechanism of MDS progression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	deregulation	deregulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
9	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	seem	seem	VERB	VB	VerbForm=Inf	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	MDS	mds	NOUN	NN	Number=Sing	_	_	_	_
24	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8555
# text = Document 0030011488 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011488	0030011488	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8556
# text = Tax-independent binding of multiple cellular factors to Tax-response element DNA of HTLV-I.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
4	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8557
# text = The human T-cell leukemia virus type I (HTLV-I) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE (Tax-response element) that is responsive to the virally encoded transactivator protein Tax.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
15	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	imperfect	imperfect	ADJ	JJ	Degree=Pos	_	_	_	_
20	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	21	21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	base	base	NOUN	NN	Number=Sing	_	_	_	_
26	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
28	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	here	here	ADV	RB	PronType=Dem	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	TRE	tre	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	virally	virally	ADV	RB	_	_	_	_	_
44	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
46	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
47	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8558
# text = We have identified and separated four nuclear proteins from C81-66-45 cells, an HTLV-I immortalized Tax-expressing human T-lymphocyte line (Salahuddin et al.,
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	four	four	NUM	CD	NumType=Card	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	C81-66	c81-66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-45	-45	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	immortalized	immortalize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	Salahuddin	Salahuddin	PROPN	NNP	Number=Sing	_	_	_	_
28	et	et	X	FW	_	_	_	_	_
29	al.	al.	X	FW	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 8559
# text = 1983), that interact with the TRE-DNA, none of which are identical with the Tax-protein.
1	1983	1983	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	none	none	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8560
# text = The proteins identified have molecular weights of about 32, 36 to 42, 50 and 110 kD.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	weights	weight	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	about	about	ADP	IN	_	_	_	_	_
9	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	36	36	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	42	42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	50	50	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	110	110	NUM	CD	NumType=Card	_	_	_	_
18	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8561
# text = Four different methods were used to identify the proteins.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	methods	method	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8562
# text = First, from different cell lines three or all four of the nuclear proteins were specifically cross-linked by UV irradiation to the radioactively labeled TRE-DNA fragment.
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	four	four	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	specifically	specifically	ADV	RB	_	_	_	_	_
17	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
21	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	radioactively	radioactively	ADV	RB	Degree=Pos	_	_	_	_
25	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
29	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8563
# text = Second, TRE-DNA binding proteins sedimented through a glycerol density gradient at rates corresponding to proteins of native molecular weights of 35 to 50 kD and 110 kD.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	sedimented	sediment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	glycerol	glycerol	NOUN	NN	Number=Sing	_	_	_	_
12	density	density	NOUN	NN	Number=Sing	_	_	_	_
13	gradient	gradient	NOUN	NN	Number=Sing	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	rates	rate	NOUN	NNS	Number=Plur	_	_	_	_
16	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	weights	weight	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	35	35	NUM	CD	NumType=Card	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	50	50	NUM	CD	NumType=Card	_	_	_	_
27	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	110	110	NUM	CD	NumType=Card	_	_	_	_
30	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8564
# text = Third, only the 50 kD protein was retained on a biotinylated DNA-streptavidin matrix when the DNA fragment contained the TRE-DNA.
1	Third	third	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	50	50	NUM	CD	NumType=Card	_	_	_	_
6	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	biotinylated	biotinylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	streptavidin	streptavidin	NOUN	NN	Number=Sing	_	_	_	_
16	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
17	when	when	ADV	WRB	PronType=Int	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
21	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	TRE	tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8565
# text = Fourth, extensive purification by several cycles of TRE-DNA affinity chromatography resulted in the 32, 36 to 42 and 110 kD proteins and to less extent the 50 kD factor.
1	Fourth	fourth	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
4	purification	purification	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
7	cycles	cycle	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	chromatography	chromatography	NOUN	NN	Number=Sing	_	_	_	_
14	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	36	36	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	42	42	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	110	110	NUM	CD	NumType=Card	_	_	_	_
24	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
29	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	50	50	NUM	CD	NumType=Card	_	_	_	_
32	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8566
# text = Two abundant proteins of 75 and 80 kD were competed out by poly[d(I-C)] in all reactions.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	75	75	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	80	80	NUM	CD	NumType=Card	_	_	_	_
8	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	competed	compet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	out	out	ADP	RP	_	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	poly	poly	ADV	RB	_	_	_	_	SpaceAfter=No
14	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	d	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	]	]	PUNCT	-RRB-	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	all	all	DET	DT	_	_	_	_	_
24	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8567
# text = The cAMP-response element CRE, TGACGTCA, present in the 21 base-pair sequence, appears to be essential for specific protein-TRE-DNA interactions because mutation of the two G's destroys this complex.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	TGACGTCA	TGACGTCA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	21	21	NUM	CD	NumType=Card	_	_	_	_
14	base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	protein-	protein-	PUNCT	:	_	_	_	_	SpaceAfter=No
26	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
30	because	because	SCONJ	IN	_	_	_	_	_
31	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	two	two	NUM	CD	NumType=Card	_	_	_	_
35	G's	G'	NOUN	NNS	Number=Plur	_	_	_	_
36	destroys	destroy	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8568
# text = This result suggests that the cAMP response element binding protein, CREB, is involved in the protein-TRE-DNA complex and in mediating the Tax response.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	in	in	SCONJ	IN	_	_	_	_	_
25	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8569
# text = Document 0030011489 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011489	0030011489	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8570
# text = ras protein activity is essential for T-cell antigen receptor signal transduction.
1	ras	ra	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8571
# text = In a Jurkat cell model of T-cell activation an interleukin-2 promoter/reporter gene construct was activated by antigen receptor agonism in combination with the lymphokine interleukin-1.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	agonism	agonism	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
30	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8572
# text = Antigen receptor signals could be mimicked by suboptimal activation of protein kinase C (PKC) with phorbol esters in combination with calcium mobilization by an ionophore.
1	Antigen	Antigen	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	suboptimal	suboptimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
19	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
24	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8573
# text = In cotransfection experiments, oncogenic rats obviated the need for PKC stimulation but did not replace either the calcium signal or interleukin-1.
1	In	in	ADP	IN	_	_	_	_	_
2	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
7	obviated	obviate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	need	need	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	replace	replace	VERB	VB	VerbForm=Inf	_	_	_	_
17	either	either	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8574
# text = Activated ras expression also replaced the requirement for PKC stimulation in activation of the T-cell transcription factor NF-AT.
1	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	replaced	replace	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8575
# text = A dominant inhibitory ras mutant specifically blocked antigen receptor agonism, indicating that ras activity is required for antigen receptor signaling.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
4	ras	ra	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
6	specifically	specifically	ADV	RB	_	_	_	_	_
7	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	agonism	agonism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	ras	ras	NOUN	NNS	Number=Plur	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	antigen	antigen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8576
# text = In addition, an inhibitor of PKC blocked both activated ras and phorbol ester stimulation, suggesting a role for ras upstream of PKC.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
8	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
14	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	role	role	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
22	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8577
# text = Document 0030011491 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011491	0030011491	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8578
# text = Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.
1	Enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	nuclear	nuclear	VERB	VB	VerbForm=Inf	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
12	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
18	SIVsmmPBj14	Sivsmmpbj14	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8579
# text = Infection with a variant of simian immunodeficiency virus, SIVsmmPBj14, leads to severe acute disease in macaques.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	SIVsmmPBj14	Sivsmmpbj14	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	severe	severe	VERB	VB	VerbForm=Inf	_	_	_	_
15	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
16	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	macaques	macaque	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8580
# text = This study was designed to investigate the functional significance of previously described mutations in the viral long terminal repeat (LTR) and to elucidate their contribution to the unique phenotype of SIVsmmPBj14.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
26	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
31	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	SIVsmmPBj14	SIVsmmPBj14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8581
# text = LTR-directed transcription was measured by using luciferase reporter constructs that were transiently transfected into cultured cells.
1	LTR-	LTR-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	directed	direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	luciferase	luciferase	ADJ	JJ	Degree=Pos	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	transiently	transiently	ADV	RB	_	_	_	_	_
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8582
# text = In a wide range of cell types, the basal transcriptional activity of the LTR from SIVsmmPBj14 was found to be 2- to 4.5-fold higher than that of an LTR from a non-acutely pathogenic strain.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
4	range	range	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	SIVsmmPBj14	SIVsmmPBj14	PROPN	NNP	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	4.5	4.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	non-acutely	non-acutely	ADV	RB	_	_	_	_	_
37	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
38	strain	strain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8583
# text = These LTRs differ by five point mutations and a 22-bp duplication in SIVsmmPBj14, which includes a nuclear factor kappa B (NF kappa B) site.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
3	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	five	five	NUM	CD	NumType=Card	_	_	_	_
6	point	point	NOUN	NN	Number=Sing	_	_	_	_
7	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	22	22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
13	duplication	duplication	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	SIVsmmPBj14	SIVsmmPBj14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8584
# text = Transcriptional differences between these LTRs were further enhanced by two- to threefold upon treatment of cells with phorbol ester or tumor necrosis factor alpha or by cotransfection with plasmids expressing NF kappa B subunits.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	further	further	ADV	RB	_	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	threefold	threefold	VERB	VB	VerbForm=Inf	_	_	_	_
14	upon	upon	ADP	IN	_	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
23	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
31	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8585
# text = Mutagenesis studies, and the use of a reporter construct containing an enhancerless promoter, indicate that these transcriptional effects are due principally to the 22-bp sequence duplication and the NF kappa B site contained within it.
1	Mutagenesis	Mutagenesis	PROPN	NNP	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	use	use	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
10	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	enhancerless	enhancerless	ADJ	JJ	Degree=Pos	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	indicate	indicate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	due	due	ADP	IN	_	_	_	_	_
23	principally	principally	ADV	RB	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	22	22	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
30	duplication	duplication	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	within	within	ADP	IN	_	_	_	_	_
39	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8586
# text = Finally, infectious virus stocks that were isogenic except for the LTR were generated.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	stocks	stock	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	isogenic	isogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	except	except	ADP	IN	_	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8587
# text = The LTR from SIVsmmPBj14 was found to confer an increase in the kinetics of virus replication in cultured cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	SIVsmmPBj14	SIVsmmPBj14	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8588
# text = Inclusion of this LTR in recombinant SIVs also resulted in a two- to threefold rise in the extent of cellular proliferation that was induced in quiescent simian peripheral blood mononuclear cells.
1	Inclusion	inclusion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
7	SIVs	SIVs	PROPN	NNP	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	threefold	threefold	VERB	VB	VerbForm=Inf	_	_	_	_
16	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
28	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
29	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
31	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8589
# text = These studies are consistent with the hypothesis that LTR mutations assist SIVsmmPBj14 in responding efficiently to cellular stimulation and allow it to replicate to high titers during the acute phase of viral infection.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
10	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
11	assist	assist	VERB	VB	VerbForm=Inf	_	_	_	_
12	SIVsmmPBj14	SIVsmmPBj14	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
15	efficiently	efficiently	ADV	RB	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
26	titers	titer	NOUN	NNS	Number=Plur	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
30	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
33	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8590
# text = Document 0030011492 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011492	0030011492	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8591
# text = [Molecular-biologic aspects of interaction between nervous and immune systems]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Molecular-	Molecular-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
4	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
11	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8592
# text = The problem of the neuro-immuno interactions on the level of the protein trans-factors, stimulating interleukin-2 (IL-2) gene expression was discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	problem	problem	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	neuro	neuro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	immuno	immuno	DET	DT	_	_	_	_	_
8	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8593
# text = The physico-chemical and functional parameters of the low molecular nuclear proteins (SP and BP- 14, 18, 19 kDs) isolated from splenic and brain cells of immunized rats were studied.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	physico	physico	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	chemical	chemical	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
11	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	SP	sp	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	BP	bp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	_
19	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	19	19	NUM	CD	NumType=Card	_	_	_	_
24	kDs	kD	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	splenic	splenic	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	brain	brain	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	immunized	immunized	ADJ	JJ	Degree=Pos	_	_	_	_
34	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
35	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8594
# text = The binding of these proteins to the regulatory region of IL-2 gene in vitro and stimulation of the IL-2mRNA synthesis in splenic T-lymphocytes culture in normal conditions were shown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
33	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8595
# text = The protective effect of SP and BP on the IL-2mRNA synthesis in stressful conditions and by the T-cells treatment with the CsA was demonstrated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protective	protective	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	SP	sp	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	BP	BP	PROPN	NNP	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	stressful	stressful	ADJ	JJ	Degree=Pos	_	_	_	_
17	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	demonstrated	demonstrated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8596
# text = Document 0030011494 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011494	0030011494	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8597
# text = Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1.
1	Interleukin	Interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	upregulates	upregulate	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	NOUN	NN	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	T	T	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8598
# text = In the present report, we studied the role of the stromal-derived cytokine interleukin-7 (IL-7) in the IL-2-gene regulation in activated T lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	7	7	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
34	T	T	PROPN	NNP	Number=Sing	_	_	_	_
35	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8599
# text = Production of IL-2 requires the formation of transcription factors involved in the IL-2-gene regulation.
1	Production	Production	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8600
# text = T-cell receptor (TCR)/CD3 engagement results in the activation of nuclear factor of activated T cells (NFAT), activator protein-1 (AP-1), and nuclear factor kappaB (NFkappaB), whereas the CD28 responsive complex (CD28RC) is activated in response to the CD28 signal.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	/CD3	/CD3	NUM	CD	NumType=Card	_	_	_	_
8	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	whereas	whereas	SCONJ	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
44	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
45	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	CD28RC	CD28RC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	response	response	NOUN	NN	Number=Sing	_	_	_	_
53	to	to	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
56	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8601
# text = Costimulation of phytohemagglutinin/anti-CD28 activated T lymphocytes with IL-7 induces a fivefold enhanced IL-2-mRNA accumulation and a 2.5-fold enhanced protein secretion.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	phytohemagglutinin/anti-CD28	phytohemagglutinin/anti-CD28	NUM	CD	NumType=Card	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	7	7	NUM	CD	NumType=Card	_	_	_	_
11	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	fivefold	fivefold	NOUN	NN	Number=Sing	_	_	_	_
14	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
26	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8602
# text = The IL-2-gene transcription rate is increased 3.4-fold, indicating that the effect of IL-7 is in part mediated at the transcriptional level.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	3.4	3.4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	7	7	NUM	CD	NumType=Card	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	part	part	NOUN	NN	Number=Sing	_	_	_	_
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8603
# text = The molecular mechanisms underlying the IL-7 effect involve the upregulation of the DNA binding activity of NFAT (60%) and AP-1 (120%), without affecting the activities of NFkappaB and CD28RC, which was confirmed by transfection assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	7	7	NUM	CD	NumType=Card	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	120	120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	without	without	SCONJ	IN	_	_	_	_	_
34	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	CD28RC	CD28RC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	which	which	PRON	WDT	PronType=Rel	_	_	_	_
43	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
44	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
47	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8604
# text = We also show that the IL-7-induced enhancement of the AP-1-DNA binding activity is not cyclosporin A-sensitive.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	cyclosporin	cyclosporin	VERB	VB	VerbForm=Inf	_	_	_	_
24	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8605
# text = Since AP-1 is part of the NFAT complex, we conclude that the IL-7-signaling pathway is involved in the activation of the fos and jun proteins of which AP-1 consists.
1	Since	since	ADP	IN	_	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	part	part	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	consists	consist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8606
# text = Document 0030011499 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011499	0030011499	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8607
# text = Differential induction of interferon (IFN)-inducible protein 10 following differentiation of a monocyte, macrophage cell lineage is related to the changes of nuclear proteins bound to IFN stimulus response element and kappaB sites.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	10	10	NUM	CD	NumType=Card	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
29	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	IFN	IFN	VERB	VB	VerbForm=Inf	_	_	_	_
32	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	element	element	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
37	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8608
# text = We examined chemokine gene expression following the differentiation of a monocyte, macrophage cell lineage.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8609
# text = The human monoblastic cell line, U937 was differentiated to macrophages by the treatment with either phorbol 12-myristate 13-acetate (PMA), retinoic acid (RA), or vitamin D3 (VitD3).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monoblastic	monoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	either	either	DET	DT	_	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
21	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
29	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
36	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8610
# text = The gene expression of interferon (IFN)-inducible protein 10 (IP-10) (a CXC chemokine) was markedly augmented by the IFNgamma treatment in PMA- or RA-differentiated U937 cells, but only marginally in undifferentiated or VitD3-treated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	CXC	Cxc	NOUN	NN	Number=Sing	_	_	_	_
21	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	markedly	markedly	ADV	RB	_	_	_	_	_
25	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
29	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	only	only	ADV	RB	_	_	_	_	_
42	marginally	marginally	ADV	RB	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
45	or	or	CCONJ	CC	_	_	_	_	_
46	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8611
# text = In contrast, another inducible gene expression of monocyte chemotactic protein-1 (a CC chemokine) and the activation of the transcriptional factor (FcRFgamma) bound to the gamma response region were similarly or less abundantly induced by IFNgamma treatment in PMA- or RA-differentiated U937 cells, indicating that increased IP-10 mRNA induction was not due to the augmented ability of the cells to respond to the presence of IFNgamma.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	another	another	DET	DT	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
10	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	CC	cc	NOUN	NN	Number=Sing	_	_	_	_
17	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	FcRFgamma	FcRFgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	region	region	NOUN	NN	Number=Sing	_	_	_	_
35	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	similarly	similarly	ADV	RB	_	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
39	abundantly	abundantly	ADV	RB	_	_	_	_	_
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
43	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	_
47	or	or	CCONJ	CC	_	_	_	_	_
48	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
55	that	that	SCONJ	IN	_	_	_	_	_
56	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	10	10	NUM	CD	NumType=Card	_	_	_	_
60	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
61	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
62	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
63	not	not	PART	RB	_	_	_	_	_
64	due	due	ADP	IN	_	_	_	_	_
65	to	to	ADP	IN	_	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	augmented	augmented	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
68	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
72	to	to	PART	TO	_	_	_	_	_
73	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
74	to	to	ADP	IN	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
77	of	of	ADP	IN	_	_	_	_	_
78	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8612
# text = Increased expression of IFNgamma-induced IP-10 mRNA following the differentiation of U937 cells was mediated largely by augmented transcriptional activity of the gene and was related to differentiation-dependent changes of the proteins bound to IFN stimulus response element (ISRE) and kB sites, suggesting that these nuclear proteins may determine the IP-10 mRNA inducibility by IFNgamma.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	U937	U937	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	largely	largely	ADV	RB	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
38	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	IFN	Ifn	VERB	VB	VerbForm=Inf	_	_	_	_
41	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	_
42	response	response	NOUN	NN	Number=Sing	_	_	_	_
43	element	element	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	ISRE	ISRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	kB	kb	NOUN	NN	Number=Sing	_	_	_	_
49	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
52	that	that	SCONJ	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
55	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
56	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
57	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
61	10	10	NUM	CD	NumType=Card	_	_	_	_
62	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
63	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
64	by	by	ADP	IN	_	_	_	_	_
65	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8613
# text = Document 0030011500 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011500	0030011500	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8614
# text = CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation.
1	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
2	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
3	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	lamina	lamina	NOUN	NN	Number=Sing	_	_	_	_
11	propria	proprion	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
16	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
18	without	without	SCONJ	IN	_	_	_	_	_
19	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8615
# text = The pathways leading to activation in lamina propria (LP) T cells are different from peripheral T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
3	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lamina	lamina	PROPN	NNP	Number=Sing	_	_	_	_
8	propria	propria	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	LP	LP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8616
# text = LP T cells exhibit enhanced IL-2 secretion when activated through the CD2 pathway.
1	LP	lp	SYM	NFP	_	_	_	_	_
2	T	t	NUM	CD	NumType=Card	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	exhibit	exhibit	NOUN	NN	Number=Sing	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8617
# text = Coligation of CD28 leads to synergistic enhancement of IL-2 secretion.
1	Coligation	Coligation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
4	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8618
# text = Previous studies have characterized the CD28 augmentation of TCR-mediated signaling in peripheral blood T cells through transcriptional activation of an IL-2 promoter CD28 response element (CD28RE), along with enhanced mRNA stability.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
7	augmentation	augmentation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	CD28RE	CD28RE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	along	along	ADP	IN	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
38	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8619
# text = This study characterized molecular events involved in CD28 costimulation of IL-2 production in LP mononuclear cells (LPMC).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	events	event	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
9	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	LP	LP	PROPN	NNP	Number=Sing	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	LPMC	LPMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8620
# text = LPMC exhibited increased IL-2 production in response to CD28 costimulation, compared with cells activated through CD2 alone.
1	LPMC	LPMC	PROPN	NNP	Number=Sing	_	_	_	_
2	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
12	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
20	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8621
# text = IL-2 secretion was paralleled by increased expression of IL-2 mRNA, resulting from enhanced IL-2 mRNA stability.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8622
# text = In contrast to transcriptional activation in PBMC, EMSA revealed that CD28 coligation of CD2-activated LPMC does not result in increased binding of trans-factors to the CD28RE, nor did Western blots detect changes in I-kappaBalpha or I-kappaBbeta levels following CD28 coligation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
13	coligation	coligation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD2	CD2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	LPMC	Lpmc	PROPN	NNP	Number=Sing	_	_	_	_
19	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	nor	nor	CCONJ	CC	_	_	_	_	_
34	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
36	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
37	detect	detect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	I	I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappaBalpha	kappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
45	-kappaBbeta	-kappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
46	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
47	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
48	CD28	Cd28	NUM	CD	NumType=Card	_	_	_	_
49	coligation	coligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8623
# text = Furthermore, CD28 coligation fails to enhance IL-2 promoter-reporter or RE/AP construct expression in CD2-activated LPMC.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
4	coligation	coligation	NOUN	NN	Number=Sing	_	_	_	_
5	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	RE	re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	_
18	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	CD2	CD2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	LPMC	Lpmc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8624
# text = The results reported herein indicate that the molecular mechanisms involved in CD28 cosignaling and regulation of IL-2 secretion in LP T cells are unique to that compartment and differ from those seen in peripheral blood T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	herein	herein	ADV	RB	_	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	CD28	Cd28	NUM	CD	NumType=Card	_	_	_	_
13	cosignaling	cosignaling	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	LP	LP	PROPN	NNP	Number=Sing	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
34	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
37	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8625
# text = These observations suggest a biological significance for different mechanisms of IL-2 activation in initiation and maintenance of the cytokine repertoire found in the mucosa.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
6	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
22	repertoire	repertoire	NOUN	NN	Number=Sing	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	mucosa	mucosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8626
# text = Document 0030011524 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011524	0030011524	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8627
# text = Transcription-independent turnover of I kappa B alpha during monocyte adherence: implications for a translational component regulating I kappa B alpha/MAD-3 mRNA levels.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
4	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
12	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
18	component	component	NOUN	NN	Number=Sing	_	_	_	_
19	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	B	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha/	alphaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
24	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8628
# text = We identified I kappa B alpha/MAD-3 as an immediate-early gene in human monocytes that is expressed in response to a variety of signals, including adhesion, lipopolysaccharide, and phorbol myristate acetate.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	_
6	alpha/	alphaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
37	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
38	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8629
# text = Within 5 min of monocyte adhesion, the level of the I kappa B alpha protein is markedly diminished but is rapidly replaced in a cycloheximide-sensitive manner within 20 min.
1	Within	within	ADP	IN	_	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	_
3	min	min	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	markedly	markedly	ADV	RB	_	_	_	_	_
19	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	rapidly	rapidly	ADV	RB	_	_	_	_	_
23	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
29	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
30	within	within	ADP	IN	_	_	_	_	_
31	20	20	NUM	CD	NumType=Card	_	_	_	_
32	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8630
# text = Accompanying the rapid turnover of the I kappa B alpha protein is simultaneous translocation of NF-kappa B-related transcription factors to nuclei of adhered monocytes.
1	Accompanying	Accompany	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
4	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	I	I	PROPN	NNP	Number=Sing	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	adhered	adher	ADJ	JJ	Degree=Pos	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8631
# text = The demonstration that NF-kappa B can regulate I kappa B alpha/MAD-3 gene transcription in other cell types suggested that the rapid increase in steady-state I kappa B alpha/MAD-3 mRNA levels we observed within 30 min of monocyte adherence would result from NF-kappa B-dependent transcriptional stimulation of the I kappa B alpha/MAD-3 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
13	alpha/	alpha/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	_
23	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	state	state	NOUN	NN	Number=Sing	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
35	alpha/	alphaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
36	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	3	3	NUM	CD	NumType=Card	_	_	_	_
39	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
40	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
41	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
42	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	within	within	ADP	IN	_	_	_	_	_
44	30	30	NUM	CD	NumType=Card	_	_	_	_
45	min	min	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
48	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
49	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
50	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
51	from	from	ADP	IN	_	_	_	_	_
52	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
55	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
58	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
59	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	I	I	PROPN	NNP	Number=Sing	_	_	_	_
63	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
64	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
65	alpha/	alpha/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
66	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
68	3	3	NUM	CD	NumType=Card	_	_	_	_
69	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8632
# text = Nuclear run-on analyses indicated that, instead, while several immediate-early cytokine genes, such as the interleukin 1 beta (IL-1 beta) gene, were transcriptionally activated during monocyte adhesion, the rate of I kappa B alpha/MAD-3 gene transcription remained constant.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
6	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	instead	instead	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	while	while	SCONJ	IN	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
35	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	during	during	ADP	IN	_	_	_	_	_
37	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
38	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
45	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
46	alpha/	alpha/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
47	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
49	3	3	NUM	CD	NumType=Card	_	_	_	_
50	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
52	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8633
# text = The adherence-dependent increase in I kappa B alpha/MAD-3 mRNA levels was also not a consequence of mRNA stabilization events.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
10	alpha/	alpha/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
11	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
23	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8634
# text = Interestingly, while increases in both IL-1 beta and I kappa B alpha/MAD-3 mRNA levels were detected in nuclei of adherent monocytes, cytoplasmic levels of IL-1 beta mRNA increased during adherence whereas those of I kappa B alpha/MAD-3 mRNA did not.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha/	alpha/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	mRNA	mRNa	SYM	SYM	_	_	_	_	_
37	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	during	during	ADP	IN	_	_	_	_	_
39	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
40	whereas	wherea	SCONJ	IN	_	_	_	_	_
41	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
45	B	B	PROPN	NNP	Number=Sing	_	_	_	_
46	alpha/	alphaith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	3	3	NUM	CD	NumType=Card	_	_	_	_
50	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
51	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
52	not	not	PART	RB	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8635
# text = Taken together, our data suggest that two interactive mechanisms regulate monocytic I kappa B alpha/MAD-3 mRNA levels.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	interactive	interactive	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	X	GW	_	_	_	_	_
15	B	benefit	X	GW	_	_	_	_	_
16	alpha/	alphaith	X	ADD	_	_	_	_	SpaceAfter=No
17	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8636
# text = We propose that adherent monocytes regulate nuclear processing (or decay) of I kappa B alpha/MAD-3 mRNA, thereby increasing mRNA levels without stimulating I kappa B alpha/MAD-3 gene transcription.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	or	or	CCONJ	CC	_	_	_	_	_
11	decay	decay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	benefit	NOUN	NN	Number=Sing	_	_	_	_
17	alpha/	alphaith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	thereby	thereby	ADV	RB	_	_	_	_	_
24	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
25	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	without	without	SCONJ	IN	_	_	_	_	_
28	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	B	PROPN	NNP	Number=Sing	_	_	_	_
32	alpha/	alphaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
33	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	3	3	NUM	CD	NumType=Card	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8637
# text = Moreover, since inhibition of protein synthesis leads to accumulation of I kappa B alpha/MAD-3 mRNA without stimulating I kappa B alpha/MAD-3 gene transcription, we suggest that low cytoplasmic levels of I kappa B alpha/MAD-3 mRNA are maintained by a translation-dependent degradation mechanism.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	since	since	ADP	IN	_	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha/	alphaith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	without	without	SCONJ	IN	_	_	_	_	_
21	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	_
25	alpha/	alphaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
26	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	3	3	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
33	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
36	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	benefit	NOUN	NN	Number=Sing	_	_	_	_
42	alpha/	alphaith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	3	3	NUM	CD	NumType=Card	_	_	_	_
46	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
47	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	translation	translation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
54	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
55	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8638
# text = Document 0030011530 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011530	0030011530	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8639
# text = Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III.
1	Cloning	Cloning	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
29	polymerases	polymerase	NOUN	NNS	Number=Plur	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8640
# text = The proximal sequence element (PSE)-binding transcription factor (PTF), which binds the PSE of both RNA polymerase II- and RNA polymerase III-transcribed mammalian small nuclear RNA (snRNA) genes, is essential for their transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PSE	PSE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	PSE	Pse	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
23	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
28	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
29	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
31	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
33	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	snRNA	snRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
45	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8641
# text = We previously reported the purification of human PTF, a complex of four subunits, and the molecular cloning and characterization of PTF gamma and delta subunits.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	purification	purification	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	PTF	PTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	four	four	NUM	CD	NumType=Card	_	_	_	_
14	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
19	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	PTF	PTF	NOUN	NN	Number=Sing	_	_	_	_
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
27	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8642
# text = Here we describe the isolation and expression of a cDNA encoding PTF beta, as well as functional studies using anti-PTF beta antibodies.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
11	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
12	PTF	Ptf	PROPN	NNP	Number=Sing	_	_	_	_
13	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
19	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	anti-PTF	anti-ptf	ADJ	JJ	Degree=Pos	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8643
# text = Native PTF beta, in either protein fractions or a PTF-Oct-1-DNA complex, can be recognized by polyclonal antibodies raised against recombinant PTF beta.
1	Native	native	ADJ	JJ	Degree=Pos	_	_	_	_
2	PTF	PTF	NOUN	NN	Number=Sing	_	_	_	_
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	either	either	DET	DT	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	PTF-	Ptf-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
23	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
24	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	against	against	ADP	IN	_	_	_	_	_
26	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
27	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	_
28	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8644
# text = Immunodepletion studies show that PTF beta is required for transcription of both classes of snRNA genes in vitro.
1	Immunodepletion	Immunodepletion	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	_
6	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	classes	classe	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8645
# text = In addition, immunoprecipitation analyses demonstrate that substantial and similar molar amounts of TATA-binding protein (TBP) and TFIIIB90 can weakly associate with PTF at low salt conditions, but this association is dramatically reduced at high salt concentrations.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
5	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	molar	molar	ADJ	JJ	Degree=Pos	_	_	_	_
12	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TBP	TBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	TFIIIB90	TFIIIB90	PROPN	NNP	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	weakly	weakly	ADV	RB	_	_	_	_	_
25	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	PTF	Ptf	NOUN	NN	Number=Sing	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
30	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
31	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	association	association	NOUN	NN	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	dramatically	dramatically	ADV	RB	_	_	_	_	_
38	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	at	at	ADP	IN	_	_	_	_	_
40	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
41	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
42	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8646
# text = Along with our previous demonstration of both physical interactions between PTF gamma/PTF delta and TBP and the involvement of TFIIIB90 in the transcription of class III snRNA genes, these results are consistent with the notion that a TBP-containing complex related to TFIIIB is required for the transcription of class III snRNA genes, and acts through weak interaction with the four-subunit PTF.
1	Along	along	ADP	IN	_	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
5	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
9	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	_
12	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	PTF	PTF	PROPN	NNP	Number=Sing	_	_	_	_
15	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	TBP	TBP	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TFIIIB90	TFIIIB90	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	class	class	NOUN	NN	Number=Sing	_	_	_	_
28	III	Iii	NUM	CD	NumType=Card	_	_	_	_
29	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	results	result	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
39	that	that	PRON	WDT	PronType=Rel	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
44	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
45	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	TFIIIB	TFIIIB	PROPN	NNP	Number=Sing	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	for	for	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	class	class	NOUN	NN	Number=Sing	_	_	_	_
55	III	iii	NUM	CD	NumType=Card	_	_	_	_
56	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
57	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
61	through	through	ADP	IN	_	_	_	_	_
62	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
63	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
64	with	with	ADP	IN	_	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	four-subunit	four-subunit	ADJ	JJ	Degree=Pos	_	_	_	_
67	PTF	Ptf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8647
# text = Document 0030011534 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011534	0030011534	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8648
# text = Functional block for 1 alpha,25-dihydroxyvitamin
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	block	block	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-dihydroxyvitamin	-dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8649
# text = D3-mediated gene regulation in human B lymphocytes.
1	D3	D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8650
# text = Elements necessary for the steroid hormone 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) to induce a biological response include the presence of specific intracellular receptors (vitamin D3 receptors (VDR)) and modulation of gene expression via hormone-activated receptor binding to regulatory regions of target genes.
1	Elements	element	NOUN	NNS	Number=Plur	_	_	_	_
2	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
6	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-dihydroxyvitamin	-dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
10	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	alpha,25-(	alpha,25-(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
32	D3	D3	NUM	CD	NumType=Card	_	_	_	_
33	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
43	via	via	ADP	IN	_	_	_	_	_
44	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
48	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
49	to	to	PART	TO	_	_	_	_	_
50	regulatory	regulatory	VERB	VB	VerbForm=Inf	_	_	_	_
51	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	target	target	NOUN	NN	Number=Sing	_	_	_	_
54	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8651
# text = These parameters were examined in normal and Epstein-Barr virus-immortalized human B cells and compared with 1 alpha,25-(OH)2D3-responsive cells of the T and monocytic lineages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	alpha,25	alpha,25	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
23	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
34	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8652
# text = Although resting tonsillar B cells did not express VDR mRNA, activation of these cells with interleukin-4 induced VDR in the absence of exogenously supplemented 1 alpha,25-(OH)2D3.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
3	tonsillar	tonsillar	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
9	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	VDR	Vdr	ADV	RBR	Degree=Cmp	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	exogenously	exogenously	ADV	RB	_	_	_	_	_
27	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	alpha,25	alpha,25	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
31	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8653
# text = As indicators of hormone-mediated gene regulation we analyzed modulation of CD23, a common B cell/monocyte surface antigen, and 24-hydroxylase.
1	As	as	SCONJ	IN	_	_	_	_	_
2	indicators	indicator	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8654
# text = 1 alpha,25-(OH)2D3 inhibited CD23 expression in U937 cells, yet failed to modulate CD23 expression in B cells.
1	1	1	NUM	CD	NumType=Card	_	_	_	_
2	alpha,25	alpha,25	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
4	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
7	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	yet	yet	CCONJ	CC	_	_	_	_	_
15	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
18	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8655
# text = Furthermore, 1 alpha,25-(OH)2D3 induced 24-hydroxylase mRNA expression and metabolic activity in both U937 cells and lectin-activated T cells, yet failed to induce 24-hydroxylase mRNA or its metabolic activity in B cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	alpha,25	alpha,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
6	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	U937	U937	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	lectin-activated	lectin-activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	yet	yet	CCONJ	CC	_	_	_	_	_
28	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
31	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
34	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
37	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8656
# text = These findings suggest that although human B lymphocytes can express VDR mRNA and protein, they exhibit a functional block for vitamin D-dependent gene regulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	although	although	SCONJ	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
11	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	exhibit	exhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	block	block	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
23	D-	D-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8657
# text = Document 0030011537 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011537	0030011537	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8658
# text = Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.
1	Tandem	tandem	PROPN	NNP	Number=Sing	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	dominant	dominant	NOUN	NN	Number=Sing	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8659
# text = A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
14	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	11	11	NUM	CD	NumType=Card	_	_	_	_
16	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8660
# text = 5' to the human epsilon-globin gene within the dominant control or locus-activating region.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8661
# text = This enhancer is inducible in K562 human erythroleukemia cells, increasing linked gamma-globin promoter/luciferase gene expression to 170-fold over an enhancerless construct.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	K562	K562	NUM	CD	NumType=Card	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
12	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	170	170	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	over	over	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	enhancerless	enhancerless	ADJ	JJ	Degree=Pos	_	_	_	_
28	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8662
# text = The enhancer consists of tandem AP-1-binding sites, phased 10 bp apart, which are both required for full activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	phased	phase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	apart	apart	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	both	both	ADV	RB	_	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8663
# text = DNA-protein binding assays with nuclear extracts from induced cells demonstrate a high molecular weight complex on the enhancer.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
14	molecular	molecular	NOUN	NN	Number=Sing	_	_	_	_
15	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8664
# text = The formation of this complex also requires both AP-1 sites and correlates with maximal enhancer activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8665
# text = Induction of the enhancer may have a role in the increase in globin gene transcription that characterizes erythroid maturation.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	characterizes	characterize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8666
# text = Enhancer activity appears to be mediated by the binding of a complex of proteins from the jun and fos families to tandem AP-1 consensus sequences.
1	Enhancer	Enhancer	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	families	family	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	tandem	tandem	VERB	VB	VerbForm=Inf	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
27	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8667
# text = Document 0030011538 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011538	0030011538	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8668
# text = Human immunodeficiency virus type 1
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 8669
# text = Nef protein inhibits NF-kappa B induction in human T cells.
1	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8670
# text = Human immunodeficiency virus type 1 (HIV-1) can establish a persistent and latent infection in CD4+ T lymphocytes (W.C.Greene, N.Engl.J.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	T	t	NUM	CD	NumType=Card	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	W.C.Greene	W.C.Greene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	N.Engl	N.Engl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.J.	.J.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 8671
# text = Med.324:308-317, 1991; S.M.Schnittman, M.C.Psallidopoulos, H.C. Lane, L.Thompson, M.Baseler, F.Massari, C.H.Fox, N.P.Salzman, and A.S.Fauci, Science 245:305-308, 1989).
1	Med.324:308-317	Med.324:308-317	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1991	1991	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	;	;	PUNCT	,	_	_	_	_	_
5	S.M.Schnittman	S.M.Schnittman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	M.C.Psallidopoulos	M.C.Psallidopoulos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	H.C.	H.C.	PROPN	NNP	Number=Sing	_	_	_	_
10	Lane	Lane	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	L.Thompson	L.Thompson	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	M.Baseler	M.Baseler	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	F.Massari	F.Massari	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	C.H.Fox	C.H.Fox	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	N.P.Salzman	N.P.Salzman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	A.S.Fauci	A.S.Fauci	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Science	science	PROPN	NNP	Number=Sing	_	_	_	_
26	245:305	245:305	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	308	308	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	1989	1989	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8672
# text = Production of HIV-1 from latently infected cells requires host cell activation by T-cell mitogens (T.Folks, D.M.Powell, M.M.Lightfoote, S.Benn, M.A. Martin, and A.S.Fauci, Science 231:600-602, 1986; D.Zagury, J. Bernard, R.Leonard, R.Cheynier, M.Feldman, P.S.Sarin, and R.C.
1	Production	Production	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	latently	latently	ADV	RB	_	_	_	_	_
8	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	host	host	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	T.Folks	T.Folk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	D.M.Powell	D.M.Powell	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	M.M.Lightfoote	M.M.Lightfoote	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	S.Benn	S.Benn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	M.A	M.A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_
29	Martin	Martin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	A.S.Fauci	A.S.Fauci	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	Science	Science	PROPN	NNP	Number=Sing	_	_	_	_
35	231:600	231:600	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-602	-602	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	1986	1986	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	;	;	PUNCT	,	_	_	_	_	_
40	D.Zagury	D.Zagury	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	J.	J.	PROPN	NNP	Number=Sing	_	_	_	_
43	Bernard	Bernard	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	R.Leonard	R.Leonard	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	R.Cheynier	R.Cheynier	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	M.Feldman	M.Feldman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	P.S.Sarin	P.S.Sarin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	R.C.	R.C.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 8673
# text = Gallo, Science 231:850-853, 1986).
1	Gallo	Gallo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Science	science	PROPN	NNP	Number=Sing	_	_	_	_
4	231:850-853	231:850-853	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	1986	1986	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8674
# text = This activation is mediated by the host transcription factor NF-kappa B [G.Nabel and D.Baltimore, Nature (London) 326:711-717, 1987].
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	host	host	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	G.Nabel	G.Nabel	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	D.Baltimore	D.Baltimore	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Nature	nature	PROPN	NNP	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	London	London	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	326:711-717	326:711-717	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	1987	1987	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8675
# text = We report here that the HIV-1-encoded
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 8676
# text = Nef protein inhibits the induction of NF-kappa B DNA-binding activity by T- cell mitogens.
1	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8677
# text = However, Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	USF	USF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	URS	URS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8678
# text = Additionally, Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
4	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
38	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8679
# text = These results indicate that defective recruitment of NF-kappa B may underlie
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
6	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 8680
# text = Nef's negative transcriptional effects on the HIV-1 and interleukin 2 promoters.
1	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	's	's	PART	POS	_	_	_	_	_
3	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8681
# text = Further evidence suggests that Nef inhibits NF-kappa B induction by interfering with a signal derived from the T-cell receptor complex.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
6	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8682
# text = Document 0030011543 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011543	0030011543	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8683
# text = Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
10	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	ADV	RB	_	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
20	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8684
# text = Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
11	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	although	although	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
29	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
30	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8685
# text = In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
12	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
19	B	B	X	LS	_	_	_	_	_
20	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8686
# text = Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	calyculin	calyculin	NOUN	NN	Number=Sing	_	_	_	_
22	A	a	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
25	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
28	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	PP	pp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	X	LS	_	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	type	type	NOUN	NN	Number=Sing	_	_	_	_
41	2A	2a	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PP	pp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
54	kappa	kappa	X	GW	_	_	_	_	_
55	B	benefit	X	GW	_	_	_	_	_
56	alpha	alpha	X	GW	_	_	_	_	_
57	even	even	ADV	RB	_	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	any	any	DET	DT	_	_	_	_	_
63	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
64	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8687
# text = This action of the phosphatase inhibitors, which is associated with the activation of the RelA.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	action	action	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	RelA.	RelA.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 8688
# text = p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha).
1	p50	p50	NUM	CD	NumType=Card	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	block	block	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	X	GW	_	_	_	_	_
20	B	b	X	GW	_	_	_	_	_
21	alpha	alpha	X	GW	_	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8689
# text = Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	calyculin	calyculin	PROPN	NNP	Number=Sing	_	_	_	_
11	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	ADV	RB	_	_	_	_	_
18	that	that	ADV	WRB	PronType=Dem	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	PP	pp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	A	a	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
42	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
48	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
49	B	b	PROPN	NNP	Number=Sing	_	_	_	_
50	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
51	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	by	by	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	two	two	NUM	CD	NumType=Card	_	_	_	_
55	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
56	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
59	B	b	NOUN	NN	Number=Sing	_	_	_	_
60	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8690
# text = However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
7	B	B	X	LS	_	_	_	_	_
8	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
18	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
24	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	B	PROPN	NNP	Number=Sing	_	_	_	_
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8691
# text = We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	calyculin	calyculin	NOUN	NN	Number=Sing	_	_	_	_
11	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
19	exhibits	exhibit	NOUN	NNS	Number=Plur	_	_	_	_
20	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
24	sensitivities	sensitivity	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
28	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8692
# text = Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	both	both	DET	PDT	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	PP	pp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	opposing	opposing	NOUN	NN	Number=Sing	_	_	_	_
30	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
36	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
37	kappa	kappa	X	GW	_	_	_	_	_
38	B	b	X	GW	_	_	_	_	_
39	alpha	alpha	X	GW	_	_	_	_	_
40	for	for	X	GW	_	_	_	_	_
41	proteasome	proteasome	X	GW	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8693
# text = Document 0030011544 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011544	0030011544	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8694
# text = LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent.
1	LPS	Lps	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	release	release	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	protein	protein	ADJ	JJ	Degree=Pos	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C	c	X	GW	_	_	_	_	_
25	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8695
# text = BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) is an important mediator of septic shock.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Tumor	tumor	PROPN	NNP	Number=Sing	_	_	_	_
4	necrosis	necrosis	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
18	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8696
# text = Endotoxin (LPS) signal transduction in human monocytes leads to activation of nuclear factor-kappa B (NF-kappaB) and TNF-alpha release.
1	Endotoxin	Endotoxin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
6	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8697
# text = Previous studies have implicated activation of both protein kinase C (PKC) and protein tyrosine kinases (PTK) in LPS-induced NF-kappaB activation and TNF-alpha production.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8698
# text = We hypothesized that inhibition of either PKC or PTK would decrease LPS-induced NF-kappaB DNA binding and TNF-alpha release in human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	either	either	CCONJ	CC	_	_	_	_	_
7	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	_
10	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
11	decrease	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
12	LPS	LPS	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8699
# text = MATERIALS AND METHODS: Human monocytes were stimulated with PMA (50 ng/ml) alone or LPS (100 ng/ml) with and without a nonspecific serine/threonine protein kinase inhibitor staurosporine (Stauro), a specific pan-PKC inhibitor bisindolylmaleimide (Bis), or an inhibitor of PTK genistein (Gen).
1	MATERIALS	material	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	50	50	NUM	CD	NumType=Card	_	_	_	_
13	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	100	100	NUM	CD	NumType=Card	_	_	_	_
22	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	without	without	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
30	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
35	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
36	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	Stauro	Stauro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
43	pan	pan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
46	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
47	bisindolylmaleimide	bisindolylmaleimide	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	Bis	Bis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	or	or	CCONJ	CC	_	_	_	_	_
53	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	_
57	genistein	genistein	PROPN	NNP	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	Gen	Gen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8700
# text = TNF-alpha release in culture supernatants was measured by an ELISA.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	release	release	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
7	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	ELISA	ELISa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8701
# text = NF-kappaB DNA binding was evaluated by electrophoretic mobility shift assay.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
10	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
11	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8702
# text = RESULTS: LPS increased NF-kappaB DNA binding and TNF-alpha release in human monocytes.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	release	release	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8703
# text = Nonspecific protein kinase inhibition inhibited NF-kappaB activation and TNF-alpha release, while specific PKC inhibition with Bis had no effect on LPS-induced NF-kappaB DNA binding or TNF-alpha release.
1	Nonspecific	Nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
19	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	Bis	Bis	PROPN	NNP	Number=Sing	_	_	_	_
22	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	no	no	DET	DT	_	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8704
# text = PTK inhibition with Gen attenuated both LPS-induced NF-kappaB DNA binding and TNF-alpha production in human monocytes.
1	PTK	Ptk	NOUN	NN	Number=Sing	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	Gen	Gen	PROPN	NNP	Number=Sing	_	_	_	_
5	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8705
# text = Direct activation of PKC with PMA induced both NF-kappaB activation and TNF-alpha production by human monocytes.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8706
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 8707
# text = These results suggest that LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes are independent of PKC activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	release	release	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	PKC	PKC	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8708
# text = Furthermore, our results provide evidence that PTK plays a role in LPS-induced NF-kappaB activation and TNF-alpha release in human monocytes and thus could be a potential therapeutic target in inflammatory states.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	thus	thus	ADV	RB	_	_	_	_	_
30	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
31	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
34	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
35	target	target	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
38	states	state	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8709
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8710
# text = Document 0030011545 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011545	0030011545	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8711
# text = Functional characterization of novel IL-2 transcriptional inhibitors.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8712
# text = IL-2-mediated T cell proliferation is a critical early event in the inflammatory process.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	event	event	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8713
# text = Formation of the NFAT-1 transcriptional complex on the IL-2 promoter is essential for IL-2 transcription.
1	Formation	Formation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NFAT	NFAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8714
# text = Using a cell line that is stably transfected with a trimer of the NFAT-1 regulatory element linked to a lac-Z reporter gene, we screened for inhibitors of NFAT-1-mediated beta-galactosidase activity.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	line	line	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	stably	stably	ADV	RB	_	_	_	_	_
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	lac	lac	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Z	Z	NOUN	NN	Number=Sing	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
29	screened	screen	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	galactosidase	galactosidase	NOUN	NN	Number=Sing	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8715
# text = WIN 61058 and WIN 53071 were identified as microM inhibitors.
1	WIN	win	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	61058	61058	NUM	CD	NumType=Card	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	WIN	win	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	53071	53071	NUM	CD	NumType=Card	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	microM	microm	ADJ	JJ	Degree=Pos	_	_	_	_
10	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8716
# text = These compounds also inhibited beta-galactosidase mRNA levels.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	galactosidase	galactosidase	NOUN	NN	Number=Sing	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8717
# text = Similar inhibition of NFAT-1-mediated gene expression was observed in a second cell line, which is stably transfected with NFAT-1 regulatory elements linked to the reporter gene for sCD8.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	stably	stably	ADV	RB	_	_	_	_	_
22	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	sCD8	sCD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8718
# text = At 10 microM, both compounds inhibited IL-2 mRNA and protein levels in the NFAT-1-linked lac-Z transfectants, and in human lymphocytes.
1	At	at	ADP	IN	_	_	_	_	_
2	10	10	NUM	CD	NumType=Card	_	_	_	_
3	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
7	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NFAT	NFAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	lac	lac	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Z	z	NOUN	NN	Number=Sing	_	_	_	_
25	transfectants	transfectant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8719
# text = Both compounds inhibited the mixed lymphocyte reaction, and this inhibition was reversed by exogenous IL-2.
1	Both	both	DET	DT	_	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
7	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8720
# text = WIN 53071 inhibited IL-2 production induced in the calcium-dependent PMA and ionomycin pathway.
1	WIN	win	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	53071	53071	NUM	CD	NumType=Card	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	_
17	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8721
# text = Conversely, calcium-independent anti-CD28
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	calcium-	calcium-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
5	anti-CD28	anti-cd28	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8722
# text = Ab and PMA-induced IL-2 production was resistant.
1	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8723
# text = Both compounds altered the NFAT-1 transcriptional complex, causing its retarded mobility on gels.
1	Both	both	DET	DT	_	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	altered	alter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NFAT	NFAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	retarded	retarded	ADJ	JJ	Degree=Pos	_	_	_	_
14	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	gels	gel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8724
# text = By these functional criteria, we believe we have identified two structurally distinct, novel inhibitors of NFAT-1-mediated transcription.
1	By	by	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	criteria	criterion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	believe	believe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	structurally	structurally	ADV	RB	_	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8725
# text = Document 0030011546 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011546	0030011546	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8726
# text = Inhibition of HIV-1 replication by combination of a novel inhibitor of TNF-alpha with AZT.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	AZT	AZT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8727
# text = The small molecule S9a was derived from an established tumor necrosis factor-alpha (TNF-alpha) inhibitor (Canventol) by replacement of the isopropylidine group with a phenyl ring.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	S9	s9	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Canventol	Canventol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	isopropylidine	isopropylidine	NOUN	NN	Number=Sing	_	_	_	_
30	group	group	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	phenyl	phenyl	NOUN	NN	Number=Sing	_	_	_	_
34	ring	ring	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8728
# text = S9a at 10 to 100 nM inhibited HIV production as potently as 3'-azido-3'-deoxythymidine (AZT), an inhibitor of viral reverse transcriptase.
1	S9a	S9a	NOUN	NN	Number=Sing	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	100	100	NUM	CD	NumType=Card	_	_	_	_
6	nM	nm	PROPN	NNP	Number=Sing	_	_	_	_
7	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	potently	potently	ADV	RB	_	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	azido	azido	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	deoxythymidine	deoxythymidine	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	AZT	AZT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
31	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8729
# text = Furthermore, S9a and AZT in combination, at noncytoxic concentrations strongly inhibited HIV-1 replication that was more than additive and substantially prolonged the appearance of virus both in acutely infected CD4+ lymphocytes (SupT) in culture and in peripheral blood mononuclear cells (PBMCs) infected with a primary HIV-1 isolate.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	S9	S9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	a	a	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	AZT	AZT	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	noncytoxic	noncytoxic	ADJ	JJ	Degree=Pos	_	_	_	_
12	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
13	strongly	strongly	ADV	RB	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	additive	additive	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	substantially	substantially	ADV	RB	_	_	_	_	_
26	prolonged	prolonge	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	both	both	CCONJ	CC	_	_	_	_	_
32	in	in	ADV	RB	_	_	_	_	_
33	acutely	acutely	ADV	RB	_	_	_	_	_
34	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	SupT	SupT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
46	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
47	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
55	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
56	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	1	1	NUM	CD	NumType=Card	_	_	_	_
59	isolate	isolate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8730
# text = S9a inhibited TNF-alpha promoter-driven reporter gene activity.
1	S9	S9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8731
# text = It was proposed that the mechanism of antiviral action of S9a was on the host cell, by blocking TNF-alpha transcription via a Tat-induced tar-independent loop, which decreases downstream NF-kappaB activation of HIV-1 long terminal repeat (LTR).
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	S9	s9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	host	host	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	via	via	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	tar-	tar-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
32	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
46	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
47	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8732
# text = S9a was superior to the first generation compound Canventol, which was superior to the natural compound sarcophytol A, demonstrating that further structure-based enhancement of potency of these compounds is feasible.
1	S9	S9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	superior	superior	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
9	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
10	Canventol	Canventol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	superior	superior	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
18	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
19	sarcophytol	sarcophytol	NOUN	NN	Number=Sing	_	_	_	_
20	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	demonstrating	demonstrate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
25	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	feasible	feasible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8733
# text = This study suggests a therapeutic approach against AIDS by application of two drugs, one against a cellular and the other a viral target, which may provide an approach to the problem of frequent emergence of resistant variants to combinations of drugs that target only HIV genes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
6	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
7	against	against	ADP	IN	_	_	_	_	_
8	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	application	application	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	against	against	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	problem	problem	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	frequent	frequent	ADJ	JJ	Degree=Pos	_	_	_	_
36	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
39	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	target	target	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	only	only	ADV	RB	_	_	_	_	_
47	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
48	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8734
# text = Document 0030011547 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011547	0030011547	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8735
# text = Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action.
1	Differentiation	Differentiation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	937	937	NUM	CD	NumType=Card	_	_	_	_
6	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	ICRF	Icrf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	193	193	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	antitumour	antitumour	NUM	CD	NumType=Card	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	topoisomerase	topoisomerase	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8736
# text = We have compared the action on U-937 human promonocytic leukemia cells of two DNA topoisomerase II inhibitors, namely the epipodophyllotoxin etoposide and the bisdioxopiperazine ICRF-193.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	action	action	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	topoisomerase	topoisomerase	NOUN	NN	Number=Sing	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	namely	namely	ADV	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	epipodophyllotoxin	epipodophyllotoxin	ADJ	JJ	Degree=Pos	_	_	_	_
24	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	bisdioxopiperazine	bisdioxopiperazine	NOUN	NN	Number=Sing	_	_	_	_
28	ICRF	Icrf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	193	193	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8737
# text = One hour pulse-treatment with 3 microM etoposide caused topoisomerase associated, primary DNA breakage, which was rapidly followed by apoptosis.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
3	pulse	pulse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-treatment	-treatment	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	microM	microm	NUM	CD	NumType=Card	_	_	_	_
8	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	_
9	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	topoisomerase	topoisomerase	NOUN	NN	Number=Sing	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	breakage	breakage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	rapidly	rapidly	ADV	RB	_	_	_	_	_
20	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8738
# text = By contrast, these effects were not observed upon pulse-treatment with 6 microM ICRF-193.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	pulse	pulse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	microM	microm	NUM	CD	NumType=Card	_	_	_	_
16	ICRF	ICRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	193	193	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8739
# text = However, continuous treatments with subcytotoxic concentrations of etoposide (0.15 microM) and ICRF-193 (0.3 microM) produced several similar effects, namely decreased cell proliferation, accumulation of cells at G2, increase in cell mass, and induction of differentiation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
4	treatments	treatment	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	subcytotoxic	subcytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
7	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	0.15	0.15	NUM	CD	NumType=Card	_	_	_	_
12	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	ICRF	ICRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	193	193	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	0.3	0.3	NUM	CD	NumType=Card	_	_	_	_
20	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
25	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	namely	namely	ADV	RB	_	_	_	_	_
28	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	G2	g2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	mass	mass	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8740
# text = Under these conditions, etoposide produced a biphasic activation of protein kinase C, which consisted in an early transient activation (from hours 1 to 6) of the membrane-bound enzyme followed by a later activation (hour 48) of the total, membrane-bound and cytosolic enzyme.
1	Under	under	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	etoposide	etoposide	ADV	RB	_	_	_	_	_
6	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	consisted	consist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	from	from	ADP	IN	_	_	_	_	_
24	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
34	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
35	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
42	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	total	total	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	membrane	membrane	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
49	-bound	-bound	ADJ	JJ	Degree=Pos	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
52	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8741
# text = By contrast, ICRF-193 only provoked a late activation (from hours 72 to 96) of the total enzyme.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	ICRF	ICRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	193	193	NUM	CD	NumType=Card	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	provoked	provoke	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	from	from	ADP	IN	_	_	_	_	_
14	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
15	72	72	NUM	CD	NumType=Card	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	96	96	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
22	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8742
# text = When used at differentiation-inducing concentrations, both topoisomerase inhibitors caused a great stimulation of AP-1 binding activity, with maximum value at hour 12 in etoposide-treated cells and at hour 48 in ICRF-193-treated cells.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	inducing	inducing	NOUN	NN	Number=Sing	_	_	_	_
7	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	topoisomerase	topoisomerase	NOUN	NN	Number=Sing	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
12	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	great	great	ADJ	JJ	Degree=Pos	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
25	value	value	NOUN	NN	Number=Sing	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
28	12	12	NUM	CD	NumType=Card	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	etoposide	etoposide	ADV	RB	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	treated	treated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
37	48	48	NUM	CD	NumType=Card	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	ICRF	ICRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	193	193	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8743
# text = By contrast, the binding activity of the NF-kappa(B) and EGR-1 transcription factors was little affected.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	little	little	ADV	RB	Degree=Pos	_	_	_	_
23	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8744
# text = It is concluded that topoisomerase II inhibitors may induce the differentiation of promonocytic cells, independently of their capacity to cause DNA strand breaks.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	topoisomerase	topoisomerase	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	independently	independently	ADV	RB	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	strand	strand	NOUN	NN	Number=Sing	_	_	_	_
24	breaks	break	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8745
# text = However, there are other effects, such as the early activation of protein kinase C, which are probably derived from the production of primary DNA breakage by some anti-topoisomerase drugs.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	there	there	PRON	EX	_	_	_	_	_
4	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	probably	probably	ADV	RB	_	_	_	_	_
21	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	breakage	breakage	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	some	some	DET	DT	_	_	_	_	_
31	anti-topoisomerase	anti-topoisomerase	ADJ	JJ	Degree=Pos	_	_	_	_
32	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8746
# text = Document 0030011549 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011549	0030011549	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8747
# text = Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity.
1	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
2	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	remote	remote	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	position	position	NOUN	NN	Number=Sing	_	_	_	_
8	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8748
# text = Previous cotransfection experiments had demonstrated that ectopic expression of the lymphocyte-specific transcription factor Oct2 could efficiently activate a promoter containing an octamer motif.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	Oct2	oct2	NOUN	NN	Number=Sing	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	efficiently	efficiently	ADV	RB	_	_	_	_	_
19	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
25	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8749
# text = Oct2 expression was unable to stimulate a multimerized octamer enhancer element in HeLa cells, however.
1	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8750
# text = We have tested a variety of Oct2 isoforms generated by alternative splicing for the capability to activate an octamer enhancer in nonlymphoid cells and a B-cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
8	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
9	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
12	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	capability	capability	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
20	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8751
# text = Our analyses show that several Oct2 isoforms can stimulate from a remote position but that this stimulation is restricted to B cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
7	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	remote	remote	ADJ	JJ	Degree=Pos	_	_	_	_
13	position	position	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8752
# text = This result indicates the involvement of either a B-cell-specific cofactor or a specific modification of a cofactor or the Oct2 protein in Oct2-mediated enhancer activation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	either	either	CCONJ	CC	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8753
# text = Mutational analyses indicate that the carboxy-terminal domain of Oct2 is critical for enhancer activation.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8754
# text = Moreover, this domain conferred enhancing activity when fused to the Oct1 protein, which by itself was unable to stimulate from a remote position.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	fused	fuse	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Oct1	Oct1	PROPN	NNP	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	remote	remote	ADJ	JJ	Degree=Pos	_	_	_	_
25	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8755
# text = The glutamine-rich activation domain present in the amino-terminal portion of Oct2 and the POU domain contribute only marginally to the transactivation function from a distal position.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	glutamine	glutamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
13	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Oct2	Oct2	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	POU	POU	NOUN	NN	Number=Sing	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	marginally	marginally	ADV	RB	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
30	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8756
# text = Document 0030011551 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011551	0030011551	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8757
# text = Effect of adenovirus 2 on cellular gene activation in blood-derived monocytes and macrophages.
1	Effect	effect	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8758
# text = We have investigated the effect of adenovirus 2 (Ad2) infection on human monocytes and monocyte-derived macrophages with regard to expression of TNF-alpha and IL-1 beta.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Ad2	Ad2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	regard	regard	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8759
# text = In monocytes, the virus was bound to the surface without being internalized.
1	In	in	ADP	IN	_	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	without	without	SCONJ	IN	_	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	internalized	internalize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8760
# text = On the other hand, Ad2 was internalized by macrophages.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Ad2	ad2	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	internalized	internalize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8761
# text = No virus replication and no transcription of the Ad2 early genes was observed in either of the cells.
1	No	no	DET	DT	_	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Ad2	Ad2	NUM	CD	NumType=Card	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	either	either	DET	DT	_	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8762
# text = Ad2 infection induced transient increase in the mRNA levels for TNF-alpha and IL-1 beta in both monocytes and in macrophages, although the kinetics of the transcription was slightly different.
1	Ad2	Ad2	NUM	CD	NumType=Card	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	although	although	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	slightly	slightly	ADV	RB	_	_	_	_	_
34	different	different	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8763
# text = The production of both cytokines, measured by ELISA tests, was enhanced in monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
10	tests	test	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8764
# text = In macrophages, a slight enhancement of TNF-alpha production was seen, whereas IL-1 beta was not detected.
1	In	in	ADP	IN	_	_	_	_	_
2	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8765
# text = The data indicate that cellular genes might be activated by Ad2 virus infection in nonpermissive cells where no viral gene products could be detected.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	Ad2	Ad2	NUM	CD	NumType=Card	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	nonpermissive	nonpermissive	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	where	where	ADV	WRB	PronType=Rel	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	products	product	NOUN	NNS	Number=Plur	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8766
# text = Document 0030011552 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011552	0030011552	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8767
# text = Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8768
# text = We have cloned a group of cDNAs representing mRNAs that are rapidly induced following adherence of human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	group	group	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
8	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
9	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	rapidly	rapidly	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8769
# text = One of the induced transcripts (MAD-3) encodes a protein of 317 amino acids with one domain containing five tandem repeats of the cdc10/ankyrin motif, which is 60% similar (46% identical) to the ankyrin repeat region of the precursor of NF-kappa B/KBF1 p50.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	3	3	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	317	317	NUM	CD	NumType=Card	_	_	_	_
16	amino	amino	DET	DT	_	_	_	_	_
17	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	one	one	NUM	CD	NumType=Card	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
22	five	five	NUM	CD	NumType=Card	_	_	_	_
23	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
24	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cdc10	cdc10	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
30	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	%	%	SYM	NN	Number=Sing	_	_	_	_
36	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	46	46	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	%	%	SYM	NN	Number=Sing	_	_	_	_
40	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
45	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	region	region	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
54	B/KBF1	B/kbf1	PROPN	NNP	Number=Sing	_	_	_	_
55	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8770
# text = The C-terminus has a putative protein kinase C phosphorylation site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	c	NOUN	NN	Number=Sing	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8771
# text = In vitro translated MAD-3 protein was found to specifically inhibit the DNA-binding activity of the p50/p65 NF-kappa B complex but not that of the p50/p50 KBF1 factor or of other DNA-binding proteins.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
3	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	specifically	specifically	ADV	RB	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	p65	p65	NUM	CD	NumType=Card	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	p50	p50	NUM	CD	NumType=Card	_	_	_	_
36	KBF1	KBF1	NUM	CD	NumType=Card	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
41	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8772
# text = The MAD-3 cDNA encodes an I kappa B-like protein that is likely to be involved in regulation of transcriptional responses to NF-kappa B, including adhesion-dependent pathways of monocyte activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	3	3	NUM	CD	NumType=Card	_	_	_	_
5	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
6	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8773
# text = Document 0030011556 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011556	0030011556	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8774
# text = Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	anetholdithiolthione	anetholdithiolthione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8775
# text = Nuclear factor (NF)-kappa B is a redox sensitive cytosolic transcription factor.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8776
# text = Redox regulation of NF-kappa B has been implicated in the activation of the human immuno-deficiency virus (HIV).
1	Redox	Redox	NOUN	NN	Number=Sing	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immuno	immuno	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-deficiency	-deficiency	NOUN	NN	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8777
# text = Therefore, inhibition of NF-kappa B activation may be an effective strategy for acquired immunodeficiency syndrome therapy.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
14	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	acquired	acquire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
19	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8778
# text = Anetholdithiolthione (ADT, 5-[p-methoxyphenyl]-3H-1,2-dithiol-3-thione) is an antioxidant which has been used to protect against acetaminophen- and CCl4-induced hepatotoxicity, lipid peroxidation, radiation injury, and also has been used clinically as an anti-choleretic agent.
1	Anetholdithiolthione	Anetholdithiolthione	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	ADT	ADT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	5-[	5-[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	p-methoxyphenyl]-3H-1,2-dithiol	p-methoxyphenyl]-3H-1,2-dithiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	thione	thione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
20	against	against	ADP	IN	_	_	_	_	_
21	acetaminophen	acetaminophe	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	CCl4	Ccl4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	hepatotoxicity	hepatotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
30	peroxidation	peroxidation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	_
33	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	also	also	ADV	RB	_	_	_	_	_
37	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	clinically	clinically	ADV	RB	_	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	anti-choleretic	anti-choleretic	ADJ	JJ	Degree=Pos	_	_	_	_
44	agent	agent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8779
# text = The present study examined the effect of ADT pretreatment on NF-kappa B activation in response to a variety of stimuli such as H2O2, phorbol myristate acetate (PMA) or tumor necrosis factor alpha (TNF alpha).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ADT	Adt	ADJ	JJ	Degree=Pos	_	_	_	_
9	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
29	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
30	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
36	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
41	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8780
# text = PMA and TNF alpha induced activation of (NF)-kappa B in human Jurkat T-cells was partially inhibited by ADT (0.1 mM) pretreatment.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	T-	t-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	partially	partially	ADV	RB	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	ADT	ADT	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	0.1	0.1	NUM	CD	NumType=Card	_	_	_	_
26	mM	mm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8781
# text = ADT (0.1 mM) also inhibited H2O2 induced activation of the transcription factor in the peroxide sensitive human Wurzburg T-cells.
1	ADT	ADT	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	0.1	0.1	NUM	CD	NumType=Card	_	_	_	_
4	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	H2O2	H2O2	PART	TO	Abbr=Yes	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
18	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	Wurzburg	Wurzburg	NOUN	NN	Number=Sing	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8782
# text = Furthermore, ADT treated Wurzburg cells had significantly higher glutathione levels as compared with untreated cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ADT	ADT	PROPN	NNP	Number=Sing	_	_	_	_
4	treated	treat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	Wurzburg	Wurzburg	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
10	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8783
# text = H2O2 induced lipid peroxidation in Wurzburg cells was remarkably inhibited by ADT pretreatment.
1	H2O2	H2O2	PART	TO	Abbr=Yes	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
4	peroxidation	peroxidation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Wurzburg	Wurzburg	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	remarkably	remarkably	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	ADT	Adt	ADJ	JJ	Degree=Pos	_	_	_	_
13	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8784
# text = ADT, a pro-glutathione antioxidant, was observed to be capable of modulating NF-kappa B activation.
1	ADT	ADT	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	pro-glutathione	pro-glutathione	ADJ	JJ	Degree=Pos	_	_	_	_
5	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	SCONJ	IN	_	_	_	_	_
13	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8785
# text = Document 0030011564 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011564	0030011564	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8786
# text = Thrombopoietin supports in vitro erythroid differentiation via its specific receptor c-Mpl in a human leukemia cell line.
1	Thrombopoietin	Thrombopoietin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	supports	support	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
5	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	via	via	ADP	IN	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Mpl	Mpl	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8787
# text = Thrombopoietin (TPO) acts on megakaryopoiesis and erythropoiesis in vitro and in vivo.
1	Thrombopoietin	Thrombopoietin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TPO	TPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	megakaryopoiesis	megakaryopoiesis	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	erythropoiesis	erythropoiesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8788
# text = We isolated a novel subline, UT-7/GMT, from the human leukemia cell line UT-7/GM (N. Komatsu, et al., Blood, 89: 4021-4033, 1997).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	subline	subline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	7/	7ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
10	GMT	GMT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	UT-7/GM	UT-7/Gm	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	N	and	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_
22	Komatsu	Komatsu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	et	et	X	FW	_	_	_	_	_
25	al.	al.	X	FW	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Blood	Blood	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	89	89	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	:	:	PUNCT	:	_	_	_	_	_
31	4021-4033	4021-4033	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	1997	1997	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8789
# text = A small population of UT-7/GM cells positively stained for hemoglobin
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	population	population	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-7/	-7ith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	GM	GM	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	positively	positively	ADV	RB	_	_	_	_	_
10	stained	stain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8790
# text = (Hb) after a 7-day exposure to TPO.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Hb	Hb	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	day	day	NOUN	NN	Number=Sing	_	_	_	_
9	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	TPO	TPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8791
# text = More than 50% of TPO-treated UT-7/GMT cells positively stained for Hb.
1	More	more	ADJ	JJR	Degree=Cmp	_	_	_	_
2	than	than	ADP	IN	_	_	_	_	_
3	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	%	%	SYM	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	TPO	TPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	GMT	Gmt	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	positively	positively	ADV	RB	_	_	_	_	_
16	stained	stain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	Hb	Hb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8792
# text = Using UT-7/GMT cells, we examined how TPO promotes hemoglobinization.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	7/	7ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
5	GMT	GMT	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	how	how	ADV	WRB	PronType=Int	_	_	_	_
11	TPO	Tpo	ADJ	JJ	Degree=Pos	_	_	_	_
12	promotes	promote	NOUN	NNS	Number=Plur	_	_	_	_
13	hemoglobinization	hemoglobinization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8793
# text = TPO induced tyrosine phosphorylation of the TPO receptor but not the erythropoietin (EPO) receptor.
1	TPO	TPo	ADP	IN	_	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TPO	TPO	PROPN	NNP	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8794
# text = There was no competition between TPO and EPO for binding to EPO receptor.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	TPO	Tpo	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	EPO	Epo	PROPN	NNP	Number=Sing	_	_	_	_
9	for	for	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8795
# text = These findings suggest that TPO has a direct effect on hemoglobinization via a specific receptor on UT-7/GMT cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TPO	TPO	PROPN	NNP	Number=Sing	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	hemoglobinization	hemoglobinization	NOUN	NN	Number=Sing	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	UT	UT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	GMT	Gmt	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8796
# text = Isoelectric focusing demonstrated that TPO induced fetal and adult
1	Isoelectric	Isoelectric	ADJ	JJ	Degree=Pos	_	_	_	_
2	focusing	focusing	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TPO	TPO	PROPN	NNP	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 8797
# text = Hb synthesis, whereas EPO induced embryonic, fetal, and adult
1	Hb	Hb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	synthesis	synthesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	whereas	whereas	SCONJ	IN	_	_	_	_	_
5	EPO	EPO	ADV	RB	_	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	adult	adult	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8798
# text = Hb synthesis.
1	Hb	Hb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	synthesis	synthesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8799
# text = Thus, our data suggest that TPO has a distinct action on erythropoiesis.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	TPO	TPO	PROPN	NNP	Number=Sing	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	action	action	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	erythropoiesis	erythropoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8800
# text = Document 0030011566 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011566	0030011566	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8801
# text = Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	start	start	NOUN	NN	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	infectivity	infectivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8802
# text = When transcriptionally active, the human immunodeficiency virus (HIV) promoter contains a nucleosome-free region encompassing both the promoter/enhancer region and a large region (255 nucleotides [nt]) downstream of the transcription start site.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	nucleosome	nucleosome	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	255	255	NUM	CD	NumType=Card	_	_	_	_
32	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
33	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	nt	not	PART	RB	_	_	_	_	SpaceAfter=No
35	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	start	start	NOUN	NN	Number=Sing	_	_	_	_
42	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8803
# text = We have previously identified new binding sites for transcription factors downstream of the transcription start site (nt 465 to 720): three AP-1 sites (I, II, and III), an AP3-like motif (AP3-L), a downstream binding factor (DBF) site, and juxtaposed Sp1 sites.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	start	start	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	nt	not	PART	RB	_	_	_	_	_
19	465	465	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	720	720	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	three	three	NUM	CD	NumType=Card	_	_	_	_
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	AP3	AP3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
42	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	L	L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
52	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
53	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	DBF	DBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	juxtaposed	juxtapose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
61	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
62	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8804
# text = Here, we show that the DBF site is an interferon-responsive factor (IRF) binding site and that the AP3-L motif binds the T-cell-specific factor NF-AT.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	DBF	DBF	NOUN	NN	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	AP3	AP3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
27	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8805
# text = Mutations that abolish the binding of each factor to its cognate site are introduced in an infectious HIV-1 molecular clone to study their effect on HIV-1 transcription and replication.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	abolish	abolish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	each	each	DET	DT	_	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8806
# text = Individual mutation of the DBF or AP3-L site as well as the double mutation AP-1(III)/AP3-L did not affect HIV-1 replication compared to that of the wild-type virus.
1	Individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
2	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	DBF	DBF	PROPN	NNP	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	double	double	ADJ	JJ	Degree=Pos	_	_	_	_
17	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	AP3	AP3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	L	l	PROPN	NNP	Number=Sing	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
31	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
35	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	type	type	NOUN	NN	Number=Sing	_	_	_	_
43	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8807
# text = In contrast, proviruses carrying mutations in the Sp1 sites were totally defective in terms of replication.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	proviruses	proviruse	NOUN	NNS	Number=Plur	_	_	_	_
5	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
6	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	totally	totally	ADV	RB	_	_	_	_	_
13	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8808
# text = Virus production occurred with slightly delayed kinetics for viruses containing combined mutations in the AP-1(III), AP3-L, and DBF sites and in the AP3-L and DBF-sites, whereas viruses mutated in the AP-1(I,II,III) and AP3-L sites and in the AP-1(I,II,III), AP3-L, and DBF sites exhibited a severely defective replicative phenotype.
1	Virus	virus	PROPN	NNP	Number=Sing	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	slightly	slightly	ADV	RB	_	_	_	_	_
6	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	_
7	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	L	l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	DBF	DBF	PROPN	NNP	Number=Sing	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	L	l	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	DBF	Dbf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	whereas	whereas	SCONJ	IN	_	_	_	_	_
43	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
44	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
53	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
55	III	III	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
61	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
62	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	in	in	ADP	IN	_	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
70	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
71	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
72	II	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
73	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
74	III	iii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
76	,	,	PUNCT	,	_	_	_	_	_
77	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
78	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
80	L	l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
81	,	,	PUNCT	,	_	_	_	_	_
82	and	and	CCONJ	CC	_	_	_	_	_
83	DBF	DBF	PROPN	NNP	Number=Sing	_	_	_	_
84	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
85	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
86	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
87	severely	severely	ADV	RB	_	_	_	_	_
88	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
89	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
90	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
91	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8809
# text = No RNA-packaging defect could be measured for any of the mutant viruses as determined by quantification of their HIV genomic RNA.
1	No	no	DET	DT	_	_	_	_	_
2	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	packaging	packaging	NOUN	NN	Number=Sing	_	_	_	_
5	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	any	any	DET	DT	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
14	viruses	virus	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	quantification	quantification	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
22	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
23	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8810
# text = Measurement of the transcriptional activity of the HIV-1 promoter after transient transfection of the HIV-1 provirus DNA or of long terminal repeat-luciferase constructs showed a positive correlation between the transcriptional and the replication defects for most mutants.
1	Measurement	Measurement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
14	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
29	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
30	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
33	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
34	between	between	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
40	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
43	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8811
# text = Document 0030011567 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011567	0030011567	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8812
# text = High-level replication of human immunodeficiency virus in thymocytes requires NF-kappaB activation through interaction with thymic epithelial cells.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	level	level	NOUN	NN	Number=Sing	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
20	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8813
# text = We have previously demonstrated that interaction of infected thymocytes with autologous thymic epithelial cells (TEC) is a prerequisite for a high level of human immunodeficiency virus type 1 (HIV-1) replication in thymocytes (M.Rothe, L.Chene, M.Nugeyre, F.Barre-Sinoussi, and N.Israel, J.Virol.72:5852-5861, 1998).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
9	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	autologous	autologous	ADJ	JJ	Degree=Pos	_	_	_	_
12	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
13	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	TEC	TEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	prerequisite	prerequisite	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
28	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
29	type	type	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	M.Rothe	M.Rothan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	L.Chene	L.Chene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	M.Nugeyre	M.Nugeyre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	F.Barre	F.Barre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	Sinoussi	Sinoussi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	N.Israel	N.Israel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	J.Virol	J.Virol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	.72:5852-	.72:5852-	SYM	SYM	_	_	_	_	SpaceAfter=No
55	5861	5861	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	1998	1998	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8814
# text = We report here that this activation of HIV replication takes place at the transcriptional level through activation of the Rel/NF-kappaB transcription factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	takes	take	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	place	place	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8815
# text = We first demonstrate that an HIV-1 provirus (SF-2 strain) very effectively replicates in thymocytes cocultured with TEC whereas this provirus, with kappaB sites deleted, fails to replicate.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	first	first	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	SF	SF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	strain	strain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	very	very	ADV	RB	_	_	_	_	_
17	effectively	effectively	ADV	RB	_	_	_	_	_
18	replicates	replicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	cocultured	coculture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	TEC	TEC	PROPN	NNP	Number=Sing	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
31	deleted	delete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	fails	fail	NOUN	NNS	Number=Plur	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8816
# text = We provide evidence that several NF-kappaB complexes are constitutively found in the nuclei of thymocytes either freshly isolated from the thymus or maintained in coculture with autologous or heterologous TEC.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
9	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	constitutively	constitutively	ADV	RB	_	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	either	either	CCONJ	CC	_	_	_	_	_
19	freshly	freshly	ADV	RB	_	_	_	_	_
20	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	coculture	coculture	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	autologous	autologous	ADJ	JJ	Degree=Pos	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
32	TEC	TEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8817
# text = The prevalent complex is the heterodimer p50-p65.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	prevalent	prevalent	ADJ	JJ	Degree=Pos	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
7	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8818
# text = NF-kappaB activity is tightly correlated with the transcriptional activity of a long terminal repeat (LTR) of HIV-1 transfected in thymocytes.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	tightly	tightly	ADV	RB	_	_	_	_	_
7	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
15	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
16	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8819
# text = The cotransfection of this LTR with a mutated IkappaBalpha molecule formally demonstrates that LTR transactivation is regulated by members of the Rel/NF-kappaB family in thymocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
11	formally	formally	ADV	RB	_	_	_	_	_
12	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	LTR	Ltr	ADJ	JJ	Degree=Pos	_	_	_	_
15	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Rel/	Rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8820
# text = We also showed that tumor necrosis factor (TNF) and to a lesser extent interleukin-1 (IL-1), secreted within the coculture, induce NF-kappaB activity and a correlative LTR transactivation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
15	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	secreted	secrete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	within	within	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	coculture	coculture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	correlative	correlative	ADJ	JJ	Degree=Pos	_	_	_	_
38	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
39	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8821
# text = However IL-7, a crucial factor for thymopoiesis that is secreted mainly by TEC, is a necessary cofactor for NF-kappaB activation elicited by TNF or IL-1.
1	However	however	ADV	RB	_	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	thymopoiesis	thymopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	mainly	mainly	ADV	RB	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	TEC	TEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
21	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8822
# text = Together, these data indicate that NF-kappaB activation, required for a high level of HIV replication in thymocytes, is regulated in a specific manner in the thymic microenvironment which provides the necessary cytokines: TNF, IL-1, and IL-7.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
32	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
37	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	:	:	PUNCT	:	_	_	_	_	_
39	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8823
# text = Document 0030011571 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011571	0030011571	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8824
# text = Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
7	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	toll	toll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8825
# text = Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens.
1	Apoptosis	Apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
15	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8826
# text = All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response.
1	All	all	DET	DT	_	_	_	_	_
2	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	_
4	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	BLPs	BLPs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	trigger	trigger	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	innate	innate	ADJ	JJ	Degree=Pos	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8827
# text = BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2).
1	BLPs	BLP	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	Toll	toll	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	hTLR2	hTLR2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8828
# text = BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2.
1	BLPs	BLP	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	initiated	initiate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	hTLR2	htlr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8829
# text = In addition, BLPs stimulated nuclear factor-kappaB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	BLPs	BLPs	PROPN	NNP	Number=Sing	_	_	_	_
5	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	host	host	NOUN	NN	Number=Sing	_	_	_	_
17	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	respiratory	respiratory	ADJ	JJ	Degree=Pos	_	_	_	_
24	burst	burst	NOUN	NN	Number=Sing	_	_	_	_
25	through	through	ADP	IN	_	_	_	_	_
26	hTLR2	hTLR2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8830
# text = Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	hTLR2	htlr2	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	link	link	NOUN	NN	Number=Sing	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
10	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	host	host	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8831
# text = Document 0030011579 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011579	0030011579	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8832
# text = A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-like	-like	ADP	IN	_	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	preferentially	preferentially	ADV	RB	_	_	_	_	_
15	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
23	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
24	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8833
# text = The proto-oncoprotein c-Rel is a member of the nuclear factor kappa B transcription factor family, which includes the p50 and p65 subunits of nuclear factor kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proto-oncoprotein	proto-oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
3	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	member	member	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	p65	p65	NUM	CD	NumType=Card	_	_	_	_
25	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8834
# text = We show here that c-Rel binds to kappa B sites as homodimers as well as heterodimers with p50.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
8	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8835
# text = These homodimers and heterodimers show distinct DNA-binding specificities and affinities for various kappa B motifs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8836
# text = In particular, the c-Rel homodimer has a high affinity for interleukin-6 (IL-6) and beta interferon kappa B sites.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
8	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8837
# text = In spite of its association with p50 in vitro, however, we found a lymphoid cell-specific nuclear factor in vivo that contains c-Rel but not p50 epitopes; this factor, termed IL-6 kappa B binding factor
1	In	in	ADP	IN	_	_	_	_	_
2	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	association	association	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	p50	p50	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	p50	p50	NUM	CD	NumType=Card	_	_	_	_
32	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	;	;	PUNCT	,	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	6	6	NUM	CD	NumType=Card	_	_	_	_
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	B	b	NOUN	NN	Number=Sing	_	_	_	_
43	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8838
# text = II, appears to contain the c-Rel homodimer and preferentially recognizes several IL-6 kappa B-related kappa B motifs.
1	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	preferentially	preferentially	ADV	RB	_	_	_	_	_
13	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8839
# text = Although it has been previously shown that the IL-6 kappa B motif functions as a potent IL-1/tumor necrosis factor-responsive element in nonlymphoid cells, its activity was found to be repressed in lymphoid cells such as a Jurkat T-cell line.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-responsive	-responsive	ADJ	JJ	Degree=Pos	_	_	_	_
27	element	element	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
38	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	lymphoid	lymphoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
43	as	as	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
46	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8840
# text = We also present evidence that IL-6 kappa B binding factor II functions as a repressor specific for IL-6 kappa B-related kappa B motifs in lymphoid cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8841
# text = Document 0030011583 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011583	0030011583	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8842
# text = Monocyte arrest and transmigration on inflamed endothelium in shear flow is inhibited by adenovirus-mediated gene transfer of IkappaB-alpha.
1	Monocyte	Monocyte	NOUN	NN	Number=Sing	_	_	_	_
2	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	transmigration	transmigration	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
10	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8843
# text = Mobilization of nuclear factor-kappaB (NF-kappaB) activates transcription of genes encoding endothelial adhesion molecules and chemokines that contribute to monocyte infiltration critical in atherogenesis.
1	Mobilization	Mobilization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	_
25	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
26	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8844
# text = Inhibition of NF-kappaB has been achieved by pharmacological and genetic approaches; however, monocyte interactions with activated endothelium in shear flow following gene transfer of the NF-kappaB inhibitor IkappaB-alpha have not been studied.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
13	approaches	approache	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
18	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
24	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
25	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
27	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	inhibitor	inhibitor	ADP	IN	_	_	_	_	_
34	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8845
# text = We found that overexpression of IkappaB-alpha in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha (TNF-alpha)-induced degradation of IkappaB-alpha and suppressed the upregulation of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 (MCP-1) and growth-related activity-alpha (GRO-alpha) by TNF-alpha.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
15	adenovirus	adenovirus	ADP	IN	_	_	_	_	_
16	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
41	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
51	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
52	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	1	1	NUM	CD	NumType=Card	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
60	,	,	PUNCT	,	_	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
64	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
67	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
68	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
69	and	and	CCONJ	CC	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
72	of	of	ADP	IN	_	_	_	_	_
73	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
74	for	for	ADP	IN	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
77	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
78	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
79	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
80	1	1	NUM	CD	NumType=Card	_	_	_	_
81	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
82	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
84	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
85	)	)	PUNCT	-RRB-	_	_	_	_	_
86	and	and	CCONJ	CC	_	_	_	_	_
87	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
89	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
90	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
91	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
92	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
93	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
94	GRO-	Gro-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
95	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
96	)	)	PUNCT	-RRB-	_	_	_	_	_
97	by	by	ADP	IN	_	_	_	_	_
98	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
99	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
100	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
101	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8846
# text = This was associated with a reduction in endothelial MCP-1 secretion and GRO-alpha immobilization.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	GRO	gro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	immobilization	immobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8847
# text = Adhesion assays under physiological shear flow conditions showed that firm arrest, spreading, and transmigration of monocytes on TNF-alpha-activated endothelium was markedly inhibited by IkappaB-alpha overexpression.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	under	under	ADP	IN	_	_	_	_	_
4	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
5	shear	shear	NOUN	NN	Number=Sing	_	_	_	_
6	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
7	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	firm	firm	ADJ	JJ	Degree=Pos	_	_	_	_
11	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	spreading	spreading	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	transmigration	transmigration	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	markedly	markedly	ADV	RB	_	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	alpha	alpha	ADP	IN	_	_	_	_	_
33	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8848
# text = Inhibition with monoclonal antibodies and peptide antagonists inferred that this was due to reduced expression of Ig integrin ligand as well as of chemokines specifically involved in these events.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
7	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
8	inferred	infer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	due	due	ADP	IN	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
18	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
20	as	as	ADV	RB	_	_	_	_	_
21	well	well	ADV	RB	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
25	specifically	specifically	ADV	RB	_	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8849
# text = In contrast, rolling of monocytes was increased by IkappaB-alpha transfer and was partly mediated by P-selectin; however, it appeared to be unaffected by the inhibition of E-selectin induction.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	rolling	rolling	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	partly	partly	ADV	RB	_	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	unaffected	unaffect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
35	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8850
# text = Thus, our data provide novel evidence that selective modulation of NF-kappaB by adenoviral transfer of IkappaB-alpha impairs the expression of multiple endothelial gene products required for subsequent monocyte arrest and emigration in shear flow and thus for monocyte infiltration in atherosclerotic plaques.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
10	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	adenoviral	adenoviral	ADJ	JJ	Degree=Pos	_	_	_	_
17	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	impairs	impair	NOUN	NNS	Number=Plur	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
27	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	products	product	NOUN	NNS	Number=Plur	_	_	_	_
30	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
33	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
34	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	emigration	emigration	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	shear	shear	ADJ	JJ	Degree=Pos	_	_	_	_
39	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	thus	thus	ADV	RB	_	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
44	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
47	plaques	plaque	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8851
# text = Document 0030011588 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011588	0030011588	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8852
# text = The hematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
11	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8853
# text = PU.1 is a hematopoietic transcription factor belonging to the Ets-family.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Ets-	ets-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8854
# text = It is identical to the Spi-1 oncogene, which is implicated in spleen focus-forming virus-induced murine erythroleukemias.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	spleen	spleen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	focus	focus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
22	erythroleukemias	erythroleukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8855
# text = PU.1 seems to be required for early development of multiple hematopoietic lineages, but its expression in mature cells is preferentially observed in cells of the B-cell-and monocyte/macrophage-differentiation lineage.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
8	development	development	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	preferentially	preferentially	ADV	RB	_	_	_	_	_
22	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	and	and	CCONJ	CC	_	_	_	_	_
31	monocyte/	monocyte/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
32	macrophage-differentiation	macrophage-differentiation	NOUN	NN	Number=Sing	_	_	_	_
33	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8856
# text = It binds the so-called Pu box, an important tissue-specific regulatory DNA element present in a number of genes expressed in these cell lineages.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Pu	Pu	NOUN	NN	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	number	number	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8857
# text = We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from early precursors to differentiated plasma cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
32	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	differentiated	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
35	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8858
# text = PU.1 mRNA expression and PU.1 DNA binding activity, as measured by Northern blot analysis and electrophoretic mobility shift assay, respectively, were evident in cell lines representing pro-B, pre-B, and mature B cells.
1	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	PU.1	PU.1	NOUN	NN	Number=Sing	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
14	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
15	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
18	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
19	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
20	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
30	pro	pro	ADP	IN	Typo=Yes	_	_	_	SpaceAfter=No
31	-B	-b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
34	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8859
# text = We could also show Pu box-dependent transactivation of a reporter gene in transient transfections in these cell lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
5	Pu	Pu	PROPN	NNP	Number=Sing	_	_	_	_
6	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	transfections	transfection	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8860
# text = In contrast, in a number of multiple myeloma cell lines, representing differentiated, plasma cell-like B cells, PU.1 DNA binding activity, mRNA expression, and Pu box-dependent transactivation were absent or detectable at a very low level.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	number	number	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	representing	represent	VERB	VBG	VerbForm=Ger	_	_	_	_
14	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Pu	Pu	PROPN	NNP	Number=Sing	_	_	_	_
33	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
41	at	at	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	very	very	ADV	RB	_	_	_	_	_
44	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
45	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8861
# text = In lymphoblastoid cell lines, which exemplify an intermediate stage of B-cell differentiation, a reduced expression and activity were observed.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	exemplify	exemplify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
10	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8862
# text = The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in plasmacytoma cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
7	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	examples	example	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	apparently	apparently	ADV	RB	_	_	_	_	_
23	contradict	contradict	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8863
# text = At present, it is unclear whether the lack of PU.1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated B cells.
1	At	at	ADP	IN	_	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
18	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	exemplifies	exemplify	NOUN	NNS	Number=Plur	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
34	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	terminally	terminally	ADV	RB	_	_	_	_	_
38	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8864
# text = Document 0030011591 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011591	0030011591	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8865
# text = Expression of v-src in T cells correlates with nuclear expression of NF-kappa B. NF-kappa B is a rapidly inducible transcriptional activator that responds to a variety of signals and influences the expression of many genes involved in the immune response.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	src	src	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	rapidly	rapidly	ADV	RB	_	_	_	_	_
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	responds	respond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
41	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
42	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8866
# text = Protein tyrosine kinases transmit signals from cytokine and immune receptors.
1	Protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
2	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	transmit	transmit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8867
# text = Very little information exists linking these two important classes of signaling molecules.
1	Very	very	ADV	RB	_	_	_	_	_
2	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
3	information	information	NOUN	NN	Number=Sing	_	_	_	_
4	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8868
# text = We now demonstrate that v-src expression correlates with nuclear expression of a kappa
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	src	src	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8869
# text = B binding complex similar to that induced by phorbol ester and ionomycin, as detected by electrophoretic mobility shift assay using a variety of kappa B sites.
1	B	b	X	LS	_	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
4	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
10	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
18	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
19	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
20	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8870
# text = This complex was blocked by the tyrosine kinase inhibitor, herbimycin A.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8871
# text = The v-src-induced complex comprised the p50 and p65 components of NF-kappa B, as determined by supershift and immunoblot analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	src-induced	src-induce	ADJ	JJ	Degree=Pos	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
5	comprised	comprise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
10	components	component	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
23	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8872
# text = As a functional correlate of this finding, transient co-transfection of HIV-1 LTR reporter constructs in a different T cell line demonstrated that v-src activated this promoter in a kappa B-dependent manner.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	finding	finding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
10	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	ADJ	JJR	Degree=Cmp	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	constructs	construct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	src	src	NOUN	NN	Number=Sing	_	_	_	_
28	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8873
# text = We found that transactivation of the HIV-1 LTR by v-src was more sensitive to mutations of the proximal, rather than the distal, kappa B element.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	src	src	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	rather	rather	ADV	RB	_	_	_	_	_
24	than	than	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	kappa	kappa	ADP	IN	_	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8874
# text = The implications for T cell receptor signaling and HIV-1 gene expression are considered.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8875
# text = Document 0030011592 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011592	0030011592	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8876
# text = Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	type	type	NOUN	NN	Number=Sing	_	_	_	_
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
29	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8877
# text = The kappa B sequence (GGGACTTTCC) binds a factor, NF-kappa B, that is constitutively found in its functional, DNA binding form only in B lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	GGGACTTTCC	GGGACTTTCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	constitutively	constitutively	ADV	RB	_	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	form	from	NOUN	NN	Number=Sing	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8878
# text = A factor with apparently indistinguishable sequence specificity can be induced in many other cell types, where it is used to regulate inducible gene expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	apparently	apparently	ADV	RB	_	_	_	_	_
5	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	where	where	ADV	WRB	PronType=Rel	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8879
# text = For example, kappa B-related sequences have been shown to be important for the transcription of a few inducible genes, such as the interleukin 2 receptor alpha-chain gene and the beta-interferon gene.
1	For	for	ADP	IN	_	_	_	_	_
2	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8880
# text = However, these genes are not constitutively active in B lymphocytes, suggesting that other regulatory mechanisms must play a role in determining the patterns of expression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
18	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
19	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8881
# text = We have investigated the constitutive and inducible transcriptional activity mediated by five kappa B-related sequence elements in two different cell types.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	five	five	NUM	CD	NumType=Card	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8882
# text = We show that in S194 plasma cells the activity of each element correlates well with the relative affinity of B-cell-derived NF-kappa B for that element.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	S194	S194	NUM	CD	NumType=Card	_	_	_	_
6	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	each	each	DET	DT	_	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
18	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8883
# text = This leads to significantly lower transcription enhancement by sites derived from the interleukin 2 receptor or T-cell receptor genes in S194 cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	lower	lower	VERB	VB	VerbForm=Inf	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	S194	S194	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8884
# text = However, in either EL-4 (T) cells or S194 cells, both lower-affinity sites can be significantly induced by the tax gene product of human T-cell leukemia virus type I, showing that NF-kappa B activity can be modulated even in a B-cell line that constitutively expresses this factor.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	either	either	DET	DT	_	_	_	_	_
5	EL	EL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	T	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	S194	S194	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	significantly	significantly	ADV	RB	_	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	product	product	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
35	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
36	type	type	NOUN	NN	Number=Sing	_	_	_	_
37	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
46	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
47	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
48	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	even	even	ADV	RB	_	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
55	line	line	NOUN	NN	Number=Sing	_	_	_	_
56	that	that	PRON	WDT	PronType=Rel	_	_	_	_
57	constitutively	constitutively	ADV	RB	_	_	_	_	_
58	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
59	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
60	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8885
# text = Document 0030011593 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011593	0030011593	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8886
# text = Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	interferon	interferon	ADP	IN	_	_	_	_	_
21	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8887
# text = Three aspects of the involvement of tumor necrosis factor in human immunodeficiency virus (HIV) pathogenesis were examined.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8888
# text = Tumor necrosis factor alpha (TNF-alpha) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected U937 cell line (U9-IIIB).
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
16	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
17	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
18	amplification	amplification	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	U937	U937	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	chronically	chronically	ADV	RB	_	_	_	_	_
27	HIV	haHive	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	U937	U937	NUM	CD	NumType=Card	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	U9-	u9-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	IIIB	Iiib	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8889
# text = TNF-alpha RNA was undetectable in U937 cells, whereas a low constitutive level was detected in U9-IIIB cells.
1	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	U937	U937	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whereas	whereas	SCONJ	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	U9-	U9-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	IIIB	Iiib	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8890
# text = Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with U937 cells, suggesting that HIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection.
1	Paramyxovirus	Paramyxovirus	NOUN	NN	Number=Sing	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	state	state	NOUN	NN	Number=Sing	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
22	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	U9	U9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	IIIB	IIIB	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
41	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
46	than	than	ADP	IN	_	_	_	_	_
47	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	after	after	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
53	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
54	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8891
# text = The effects of TNF-alpha on gene expression were examined by transient expression assays using reporter chloramphenicol acetyltransferase plasmids linked to regulatory elements from the HIV long terminal repeat (LTR) and the beta interferon promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	assays	assays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
19	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
20	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
21	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
28	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
29	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
30	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
37	interferon	interferon	ADP	IN	_	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8892
# text = In U937 and Jurkat T lymphoid cells, the inducibility of the different hybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of NF-kappa B-containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity.
1	In	in	ADP	IN	_	_	_	_	_
2	U937	U937	NUM	CD	NumType=Card	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
14	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
15	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
22	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
23	varied	vary	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
48	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
49	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	directly	directly	ADV	RB	_	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
57	B	b	PROPN	NNP	Number=Sing	_	_	_	_
58	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
61	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8893
# text = Although the intact beta interferon promoter was only weakly stimulated by phorbol ester or TNF-alpha, multimers of the PRDII NF-kappa B-binding domain were inducible by both agents.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	only	only	ADV	RB	_	_	_	_	_
9	weakly	weakly	ADV	RB	_	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	multimers	multimer	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	PRDII	PRDII	PROPN	NNP	Number=Sing	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	both	both	DET	DT	_	_	_	_	_
34	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8894
# text = TNF-alpha was able to increase expression of the HIV LTR in T cells, but in monocytic cells, TNF-alpha did not induce the HIV LTR above a constitutive level of activity.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
12	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
30	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
31	above	above	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8895
# text = This level of NF-kappa B-independent activity appears to be sufficient for virus multiplication, since TNF-alpha treatment had no effect on the kinetics of de novo HIV type 1 (HIV-1) infection and viral RNA production in U937 cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	multiplication	multiplication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	since	since	SCONJ	IN	_	_	_	_	_
20	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	no	no	DET	DT	_	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	de	de	PROPN	NNP	Number=Sing	_	_	_	_
32	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
33	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
34	type	type	NOUN	NN	Number=Sing	_	_	_	_
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
44	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
45	production	production	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	U937	U937	NUM	CD	NumType=Card	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8896
# text = However, in Jurkat cells, TNF-alpha dramatically enhanced the spread of HIV-1 through the cell population and increased viral RNA synthesis, indicating that in T cells HIV-1 multiplication was stimulated by TNF-alpha treatment.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
10	dramatically	dramatically	ADV	RB	_	_	_	_	_
11	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	spread	spread	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	population	population	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
25	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
26	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	multiplication	multiplication	NOUN	NN	Number=Sing	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	alpha	alpha	ADP	IN	_	_	_	_	_
43	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8897
# text = Document 0030011601 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011601	0030011601	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8898
# text = Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene.
1	Polymorphic	Polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
2	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
3	within	within	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	mediate	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8899
# text = Atopy, which predisposes individuals to develop asthma, severe systemic anaphylaxis, and atopic dermatitis, is usually associated with dramatically elevated total serum IgE levels and is thought to be controlled by a major susceptibility gene and multiple minor susceptibility genes.
1	Atopy	Atopy	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	predisposes	predispose	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
8	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
11	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
12	anaphylaxis	anaphylaxis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
16	dermatitis	dermatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	usually	usually	ADV	RB	_	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	dramatically	dramatically	ADV	RB	_	_	_	_	_
23	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
25	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
26	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
37	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
41	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
42	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
43	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8900
# text = A recent sib-pair analysis revealed a tight linkage between markers on 5q31.1 and a major susceptibility gene controlling total serum IgE levels.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	sib-pair	sib-pair	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
8	linkage	linkage	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	5q31.1	5q31.1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
16	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
19	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
20	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
21	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8901
# text = Due to its location within this cluster and its biologic role in Ig class switching and Th2 cell differentiation, the IL-4 gene has emerged as one major candidate for the atopy gene.
1	Due	due	ADP	IN	_	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	location	location	NOUN	NN	Number=Sing	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	switching	switching	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	emerged	emerge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	one	one	NUM	CD	NumType=Card	_	_	_	_
30	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
31	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	atopy	atopy	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8902
# text = In one model, polymorphisms within IL-4 regulatory elements might result in overexpression of the gene, amplifying Th2 cell differentiation and class switching to IgE.
1	In	in	ADP	IN	_	_	_	_	_
2	one	one	NUM	CD	NumType=Card	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	amplifying	amplify	VERB	VBG	VerbForm=Ger	_	_	_	_
21	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	class	class	NOUN	NN	Number=Sing	_	_	_	_
26	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8903
# text = In support of this model, we report that the human IL-4 promoter exists in multiple allelic forms that exhibit distinct transcriptional activities in IL-4-positive T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	support	support	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	allelic	allelic	ADJ	JJ	Degree=Pos	_	_	_	_
20	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	exhibit	exhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8904
# text = A particular allele has an unusually high transcriptional activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
3	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	unusually	unusually	ADV	RB	_	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8905
# text = A nucleotide substitution within a recently described OAP40 element located just upstream of an NF-AT site (P sequence) appears to be largely responsible for the increased promotor strength of this particular allelic form of the IL-4 promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
3	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
4	within	within	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	recently	recently	ADV	RB	_	_	_	_	_
7	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	OAP40	OAP40	NUM	CD	NumType=Card	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	just	just	ADV	RB	_	_	_	_	_
12	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	P	p	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	largely	largely	ADV	RB	_	_	_	_	_
27	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	promotor	promotor	NOUN	NN	Number=Sing	_	_	_	_
32	strength	strength	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
36	allelic	allelic	ADJ	JJ	Degree=Pos	_	_	_	_
37	form	form	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	4	4	NUM	CD	NumType=Card	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8906
# text = In EMSAs, this substitution results in a markedly enhanced affinity for sequence-specific complexes exhibiting an AP-1 specificity.
1	In	in	ADP	IN	_	_	_	_	_
2	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	markedly	markedly	ADV	RB	_	_	_	_	_
10	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	exhibiting	exhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8907
# text = The identification of allelic nucleotides, which results in overexpression of the IL-4 gene, provides specific targets for a comprehensive screening of atopic and nonatopic individuals and may provide a clue for genetic predisposition for atopy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	allelic	allelic	ADJ	JJ	Degree=Pos	_	_	_	_
5	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	DET	WDT	PronType=Int	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	comprehensive	comprehensive	ADJ	JJ	Degree=Pos	_	_	_	_
24	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	nonatopic	nonatopic	ADJ	JJ	Degree=Pos	_	_	_	_
29	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	clue	clue	NOUN	NN	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
37	predisposition	predisposition	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	atopy	atopy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8908
# text = Document 0030011602 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011602	0030011602	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8909
# text = Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes.
1	Comparative	Comparative	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8910
# text = Nuclear factor of activated T cells (NFAT) is a transcriptional activator that binds to sequences in the interleukin-2 (IL-2) promoter and is thought to be largely responsible for the T cell-specific inducibility of IL-2 expression.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	largely	largely	ADV	RB	_	_	_	_	_
35	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	T	T	PROPN	NNP	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
42	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	2	2	NUM	CD	NumType=Card	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8911
# text = Electrophoretic mobility shift assays (EMSA) showed that specific NFAT binding activity could also be induced in human B cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	NFAT	Nfat	SCONJ	IN	_	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8912
# text = The B cell NFAT complex, however, was not functional, since it failed to activate transcription from an NFAT-driven chloramphenicol acetyltransferase (CAT) construct.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	SCONJ	IN	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
25	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8913
# text = Competition with an AP-1 motif or with anti-Jun and anti-Fos antibodies abolished binding to the NFAT motif in both T and B cells, indicating that Jun and Fos are critical for NFAT complex formation in both cell types.
1	Competition	competition	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	anti-Jun	anti-Jun	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	anti-Fos	anti-Fos	ADJ	JJ	Degree=Pos	_	_	_	_
13	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
14	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
19	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
36	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
37	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	both	both	DET	DT	_	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8914
# text = Purified recombinant Jun and Fos proteins failed to bind directly to the NFAT motif.
1	Purified	Purify	ADJ	JJ	Degree=Pos	_	_	_	_
2	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
3	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	directly	directly	ADV	RB	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
14	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8915
# text = However, when combined with unstimulated B or T cell extracts, full-length, but not truncated, Jun/Fos heterodimers were able to form an NFAT complex, indicating the presence of a constitutively expressed nuclear factor(s) in B and T cells necessary for the formation of the NFAT complex in both cell types.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	length	length	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Jun/	Jun/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
22	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
23	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
30	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	constitutively	constitutively	ADV	RB	_	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	s	s	X	AFX	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	B	b	PROPN	NNP	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
50	for	for	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
56	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
57	in	in	ADP	IN	_	_	_	_	_
58	both	both	DET	DT	_	_	_	_	_
59	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
60	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8916
# text = An NFAT oligonucleotide carrying mutations in the 5' purine-rich part of the NFAT sequence failed to form a complex and to compete with the wild type motif for NFAT complex formation in both T and B cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
3	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
4	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
5	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	's	PUNCT	``	_	_	_	_	_
10	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
13	part	part	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	wild	wild	NOUN	NN	Number=Sing	_	_	_	_
29	type	type	NOUN	NN	Number=Sing	_	_	_	_
30	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
33	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
34	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	both	both	CCONJ	CC	_	_	_	_	_
37	T	T	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8917
# text = We therefore propose a model whereby a core NFAT complex consisting of Jun, Fos, and a constitutive nuclear factor is formed in both T and B cells, but an additional factor and/or post-translational modification of a factor, missing in B cells, might be required for transactivation by NFAT.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	whereby	whereby	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	or	or	CCONJ	CC	_	_	_	_	_
38	post-translational	post-translational	ADJ	JJ	Degree=Pos	_	_	_	_
39	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	missing	missing	VERB	VBG	VerbForm=Ger	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
50	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
51	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	for	for	ADP	IN	_	_	_	_	_
53	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
54	by	by	ADP	IN	_	_	_	_	_
55	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8918
# text = Document 0030011619 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011619	0030011619	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8919
# text = Dimethyldithiocarbamate inhibits in vitro activation of primary human CD4+ T lymphocytes.
1	Dimethyldithiocarbamate	Dimethyldithiocarbamate	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8920
# text = Dithiocarbamates (DTC), a diverse group of industrial and therapeutic chemicals, have been reported to inhibit, enhance or have no effect on the immune system.
1	Dithiocarbamates	Dithiocarbamates	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	DTC	DTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
8	group	group	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	industrial	industrial	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
13	chemicals	chemical	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	no	no	DET	DT	_	_	_	_	_
25	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
29	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8921
# text = These apparent inconsistencies reflect the complexity of the DTCs biological activities and are probably due in part to differences in dose, route of exposure, animal species used and/or specific compound tested.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
3	inconsistencies	inconsistency	NOUN	NNS	Number=Plur	_	_	_	_
4	reflect	reflect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	complexity	complexity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DTCs	DTC	NOUN	NNS	Number=Plur	_	_	_	_
10	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	probably	probably	ADV	RB	_	_	_	_	_
15	due	due	ADP	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	part	part	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	route	route	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
28	species	species	NOUN	NNS	Number=Plur	_	_	_	_
29	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	or	or	CCONJ	CC	_	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
35	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8922
# text = The studies described herein were undertaken to investigate the immunotoxicity of one member of this family, dimethyldithiocarbamate (DMDTC).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	described	describe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	herein	herein	ADV	RB	_	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	immunotoxicity	immunotoxicity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	member	member	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	dimethyldithiocarbamate	dimethyldithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	DMDTC	Dmdtc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8923
# text = We demonstrate that 0.1-0.5 microM
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	0.1	0.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
7	microM	microm	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8924
# text = DMDTC inhibits TNF-alpha-induced activation of NF-kappaB in primary human CD4+ T cells.
1	DMDTC	Dmdtc	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8925
# text = This inhibition is not accompanied by a loss in viability, and DMDTC-treated T cells retain other active signaling pathways throughout the exposure duration.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	viability	viability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	DMDTC	DMDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	retain	retain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
22	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
23	throughout	throughout	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
26	duration	duration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8926
# text = The inhibition of NF-kappaB is apparently permanent as DMDTC-treated T cells did not regain normal TNF-alpha activation, even after 72 h in culture.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	apparently	apparently	ADV	RB	_	_	_	_	_
9	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	DMDTC	DMDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	regain	regain	VERB	VB	VerbForm=Inf	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	even	even	ADV	RB	_	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	72	72	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8927
# text = DMDTC does not appear to alter NF-kappaB directly as pre-incubation of nuclear extracts with DMDTC does not diminish binding activity of this protein.
1	DMDTC	DMDTC	NOUN	NN	Number=Sing	_	_	_	_
2	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	directly	directly	ADV	RB	_	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	pre-incubation	pre-incubation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	DMDTC	DMDTC	NOUN	NN	Number=Sing	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	diminish	diminish	VERB	VB	VerbForm=Inf	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8928
# text = We further demonstrate that 0.1-0.5 microM
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	0.1	0.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
8	microM	microm	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 8929
# text = DMDTC inhibits intracellular IL-2 production and decreases surface expression of CD25 (the alpha subunit of the IL-2 receptor) in T cells stimulated with phorbol ester.
1	DMDTC	Dmdtc	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
4	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CD25	CD25	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
31	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8930
# text = These data demonstrate that DMDTC is a potent immunosuppressive compound in vitro.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DMDTC	DMDTC	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
9	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8931
# text = Document 0030011620 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011620	0030011620	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8932
# text = Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.
1	Distinctive	Distinctive	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
8	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
12	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8933
# text = cDNA microarrays and a clustering algorithm were used to identify patterns of gene expression in human mammary epithelial cells growing in culture and in primary human breast tumors.
1	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
2	microarrays	microarray	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	clustering	clustering	NOUN	NN	Number=Sing	_	_	_	_
6	algorithm	algorithm	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
11	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
18	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
28	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8934
# text = Clusters of coexpressed genes identified through manipulations of mammary epithelial cells in vitro also showed consistent patterns of variation in expression among breast tumor samples.
1	Clusters	Cluster	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	manipulations	manipulation	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
10	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
17	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	among	among	ADP	IN	_	_	_	_	_
23	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8935
# text = By using immunohistochemistry with antibodies against proteins encoded by a particular gene in a cluster, the identity of the cell type within the tumor specimen that contributed the observed gene expression pattern could be determined.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	specimen	speciman	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	contributed	contribute	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
34	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8936
# text = Clusters of genes with coherent expression patterns in cultured cells and in the breast tumors samples could be related to specific features of biological variation among the samples.
1	Clusters	Cluster	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	coherent	coherent	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
15	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
16	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
25	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
26	among	among	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8937
# text = Two such clusters were found to have patterns that correlated with variation in cell proliferation rates and with activation of the IFN-regulated signal transduction pathway, respectively.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	clusters	cluster	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
8	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
16	rates	rate	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
27	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8938
# text = Clusters of genes expressed by stromal cells and lymphocytes in the breast tumors also were identified in this analysis.
1	Clusters	Cluster	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
13	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8939
# text = These results support the feasibility and usefulness of this systematic approach to studying variation in gene expression patterns in human cancers as a means to dissect and classify solid tumors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	feasibility	feasibility	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	usefulness	usefulness	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	systematic	systematic	ADJ	JJ	Degree=Pos	_	_	_	_
11	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	SCONJ	IN	_	_	_	_	_
13	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
14	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	means	means	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	dissect	dissect	VERB	VB	VerbForm=Inf	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	classify	classify	VERB	VB	VerbForm=Inf	_	_	_	_
29	solid	solid	ADJ	JJ	Degree=Pos	_	_	_	_
30	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8940
# text = Document 0030011626 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011626	0030011626	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8941
# text = Nuclear levels of NF-kappaB correlate with syncytium-forming capacity of 8e51 cells, expressing a defective HIV virus.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	syncytium	syncytium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
12	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	8e51	8e51	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8942
# text = The double NF-kappaB site identified in the LTR of the human immunodeficiency virus-1 (HIV-1) has been demonstrated to be necessary for efficient viral transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	double	double	ADJ	JJ	Degree=Pos	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
31	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8943
# text = In this report we present the characterisation of NF-kappaB subunits engaged in complexes binding to the HIV-1 NF-kappaB site in human 8e51 T-cells, that harbour a defective HIV-1.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	present	present	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	characterisation	characterisation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	engaged	engage	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	8e51	8e51	NUM	CD	NumType=Card	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	harbour	harbour	PRON	PRP$	Person=2|Poss=Yes|PronType=Prs	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
36	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8944
# text = At least four different specific NF-kappaB complexes are present in the nucleus of these cells.
1	At	at	ADV	RB	_	_	_	_	_
2	least	least	ADV	RBS	Degree=Sup	_	_	_	_
3	four	four	NUM	CD	NumType=Card	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
9	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8945
# text = With the use of specific antibodies we have determined the composition of each complex using electrophoretic mobility shift assays.
1	With	with	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	use	use	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	each	each	DET	DT	_	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
17	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
18	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
19	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8946
# text = The results show the presence of several NF-kappaB family members, with the transactivating RelA being engaged in multiple complexes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transactivating	transactivating	NOUN	NN	Number=Sing	_	_	_	_
17	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
18	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
19	engaged	engage	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
22	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8947
# text = The importance of NF-kappaB complexes in viral functions has been established comparing the level of NF-kappaB DNA-binding complexes with syncytia-forming activity of 8e51 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	comparing	compare	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	8e51	8e51	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8948
# text = In fact, 8e51 cells that had almost lost their syncytia-forming capacity were found to contain at least 10 times less active NF-kappaB DNA-binding complex than the actively fusing cells.
1	In	in	ADP	IN	_	_	_	_	_
2	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	8e51	8e51	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	almost	almost	ADV	RB	_	_	_	_	_
9	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-forming	-forming	VERB	VBG	VerbForm=Ger	_	_	_	_
13	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	times	time	NOUN	NNS	Number=Plur	_	_	_	_
22	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
23	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
31	than	than	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	actively	actively	ADV	RB	_	_	_	_	_
34	fusing	fusing	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8949
# text = The correlation is specific as the level of at least three other transcription factors did not change.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	at	at	ADV	RB	_	_	_	_	_
10	least	least	ADV	RBS	Degree=Sup	_	_	_	_
11	three	three	NUM	CD	NumType=Card	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	change	change	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8950
# text = Document 0030011633 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011633	0030011633	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8951
# text = DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	triplex	triplex	NOUN	NN	Number=Sing	_	_	_	_
3	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
4	selectively	selectively	ADV	RB	_	_	_	_	_
5	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8952
# text = Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth factor that is expressed in activated T cells, fibroblasts, macrophages, and endothelial cells.
1	Granulocyte	Granulocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8953
# text = Although GM-CSF does not appear to be essential for normal hemopoiesis, overexpression of GM-CSF has been implicated in the pathogenesis of some diseases such as myeloid leukemia and chronic inflammation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
5	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	hemopoiesis	hemopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	some	some	DET	DT	_	_	_	_	_
28	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
29	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	myeloid	myeloid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
35	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8954
# text = An NF-kappaB/Rel binding site within the GM-CSF promoter, termed the kappaB element appears to be important for controlling expression in reporter gene assays in response to a number of stimuli in T cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	termed	term	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	SCONJ	IN	_	_	_	_	_
25	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	number	number	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	T	t	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8955
# text = We investigated oligonucleotide-directed triple helix formation across this regulatory sequence as a potential tool to inhibit GM-CSF gene transcription.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	triple	triple	NOUN	NN	Number=Sing	_	_	_	_
7	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
8	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
9	across	across	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
16	tool	tool	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
19	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8956
# text = A 15-base oligonucleotide, GM3, was targeted to a purine-rich region in the GM-CSF proximal promoter, which overlaps the kappaB element.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	base	base	NOUN	NN	Number=Sing	_	_	_	_
5	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	GM3	GM3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
22	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8957
# text = Gel mobility shift assays and DNase I footprinting demonstrated that GM3 formed a sequence-specific collinear triplex with its double-stranded DNA target.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	footprinting	footprint	AUX	VBG	VerbForm=Ger	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	GM3	GM3	NOUN	NN	Number=Sing	_	_	_	_
12	formed	form	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	collinear	collinear	NOUN	NN	Number=Sing	_	_	_	_
18	triplex	triplex	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	target	target	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8958
# text = Triplex formation by GM3 blocked recombinant and nuclear NF-kappaB proteins binding to the GM-CSF element.
1	Triplex	Triplex	NOUN	NN	Number=Sing	_	_	_	_
2	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	GM3	GM3	NUM	CD	NumType=Card	_	_	_	_
5	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8959
# text = GM3 also caused selective inhibition of the human T-cell lymphotrophic virus-1 Tax transactivator-induced luciferase activity from a reporter construct driven by the GM-CSF promoter in Jurkat T cells.
1	GM3	GM3	NOUN	NN	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lymphotrophic	lymphotrophic	ADJ	JJ	Degree=Pos	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
16	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
25	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
34	T	T	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8960
# text = Finally, GM3 greatly reduced the concentration of endogenous GM-CSF mRNA induced by different stimuli in Jurkat T cells but did not affect interleukin 3 mRNA levels in the same cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	GM3	GM3	NUM	CD	NumType=Card	_	_	_	_
4	greatly	greatly	ADV	RB	_	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
26	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
27	3	3	NUM	CD	NumType=Card	_	_	_	_
28	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
29	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8961
# text = We conclude that the kappaB element in the GM-CSF promoter plays a central role in the transcriptional activation of the endogenous GM-CSF gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
24	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8962
# text = Colinear triplex formation acts as a selective transcriptional repressor of the GM-CSF gene and may have potential therapeutic application in cases of undesirable overexpression of this protein.
1	Colinear	Colinear	ADJ	JJ	Degree=Pos	_	_	_	_
2	triplex	triplex	NOUN	NN	Number=Sing	_	_	_	_
3	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
4	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
19	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
20	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
21	application	application	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	undesirable	undesirable	ADJ	JJ	Degree=Pos	_	_	_	_
26	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8963
# text = Document 0030011637 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011637	0030011637	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8964
# text = Association between expression of intercellular adhesion molecule-1 and integration of human T-cell-leukemia virus type 1 in adult T-cell leukemia cells.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-cell	T-cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
22	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8965
# text = It is known that the expression levels of intercellular adhesion molecule-1 (ICAM-1) in adult T cell leukemia(ATL) cells are high, whereas those in T-lymphoid cells are not.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
11	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
23	leukemia	leukemia	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8966
# text = In order to investigate the factors that influence the induction of ICAM-1 molecules, Northern blot analysis to measure the expression level of ICAM-1 mRNAs and Southern blot hybridization to analyze the integration of human T-cell-leukemia virus type 1 (HTLV-1) provirus were done.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	influence	influence	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
18	blot	blot	ADJ	JJ	Degree=Pos	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	measure	measure	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Southern	Southern	ADJ	JJ	Degree=Pos	_	_	_	_
32	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
33	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
40	T-cell	T-cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
43	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
44	type	type	NOUN	NN	Number=Sing	_	_	_	_
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	done	do	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8967
# text = The levels of ICAM-1 mRNA expression of ATL cells were generally higher than those of T-lymphoid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	generally	generally	ADV	RB	_	_	_	_	_
14	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
15	than	than	ADP	IN	_	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8968
# text = However, ILT-mat cells and ATL16T(-) cells, although they were ATL cells, showed rather low surface ICAM-1 expression and ICAM-1 mRNA expression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ILT	ILT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mat	mat	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	ATL16T	Atl16t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	-)	-)	PUNCT	.	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	although	although	SCONJ	IN	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	rather	rather	ADV	RB	_	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8969
# text = Southern blot hybridization showed that only two and four bands were found in ILT-mat and ATL16T(-) cells, respectively, whereas > 10 bands were detected in other ATL cells.
1	Southern	southern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	four	four	NUM	CD	NumType=Card	_	_	_	_
10	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	ILT	ILT	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mat	mat	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	ATL16T	Atl16t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	-)	-)	PUNCT	.	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	NOUN	NNS	Number=Plur	_	_	_	_
26	>	>	PUNCT	,	_	_	_	_	_
27	10	10	NUM	CD	NumType=Card	_	_	_	_
28	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8970
# text = These results suggest that monoclonal integration of HTLV-1 provirus to the genome of T cell, especially the number of integration sites, is one of the factors for induction of ICAM-1 molecules.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	especially	especially	ADV	RB	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	number	number	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
24	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	one	one	NUM	CD	NumType=Card	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8971
# text = Document 0030011642 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011642	0030011642	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8972
# text = Induction of nuclear factor kappa B/Rel nuclear activity in human peripheral blood T lymphocytes by anti-HLA class I monoclonal antibodies.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	anti-HLA	anti-hla	ADJ	JJ	Degree=Pos	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
22	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8973
# text = Monoclonal antibodies against either monomorphic or polymorphic determinants of class I antigen induced in PBMC and highly purified T lymphocytes the nuclear activity of NF-kappa B/Rel complexes.
1	Monoclonal	Monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
2	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
3	against	against	ADP	IN	_	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	monomorphic	monomorphic	ADJ	JJ	Degree=Pos	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
8	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	highly	highly	ADV	RB	_	_	_	_	_
18	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
31	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8974
# text = These included both p50/p50 and p50/p65 dimers, recognized by specific antibodies in EMSA.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	p50/p50	p50/p50	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
9	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8975
# text = The induced complexes were detectable in extracts of cells incubated with anti-class I monoclonal antibody (mAb) for 1.5 h; the induction was maximal at 5 h, persistent at 16 h and no longer observed at 40 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induced	induced	ADJ	JJ	Degree=Pos	_	_	_	_
3	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	anti-class	anti-class	NOUN	NN	Number=Sing	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
15	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	1.5	1.5	NUM	CD	NumType=Card	_	_	_	_
21	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	5	5	NUM	CD	NumType=Card	_	_	_	_
29	h	h	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	16	16	NUM	CD	NumType=Card	_	_	_	_
34	h	h	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	no	no	ADV	RB	_	_	_	_	_
37	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
38	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	at	at	ADP	IN	_	_	_	_	_
40	40	40	NUM	CD	NumType=Card	_	_	_	_
41	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8976
# text = The mAb failed to induce NF-kappa B/Rel nuclear activity in cells incubated in the presence of 3,4-dichloroisocoumarin, an inhibitor of I kappa B-alpha degradation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
3	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	3,4	3,4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-dichloroisocoumarin	-dichloroisocoumarin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8977
# text = Together, these results suggest that class I triggering can induce the activity of NF-kappa
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 8978
# text = B/Rel nuclear activity in peripheral blood T lymphocytes, thereby modulating the expression of genes regulated by these transcription factors.
1	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	T	t	NOUN	NN	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	thereby	thereby	ADV	RB	_	_	_	_	_
13	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8979
# text = Document 0030011650 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011650	0030011650	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8980
# text = IL-12-induced activation of NK and T cells occurs in the absence of immediate-early activation gene expression.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8981
# text = The responses of lymphocytes to IL-2 and IL-12, involving proliferation, differentiation, and cytokine production, are only partially overlapping, and may depend on induced differential expression of specific sets of genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	partially	partially	ADV	RB	_	_	_	_	_
26	overlapping	overlapping	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8982
# text = Using reverse-transcription PCR differential display, we isolated an mRNA species expressed in IL-2- but not IL-12-stimulated NK cells.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	PCR	Pcr	ADP	IN	_	_	_	_	_
6	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
7	display	display	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mRNA	mRNa	ADJ	JJ	Degree=Pos	_	_	_	_
13	species	species	NOUN	NNS	Number=Plur	_	_	_	_
14	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8983
# text = This was identified as the mRNA encoding the transcription factor egr-1, which is expressed with fast kinetics in T and NK cells upon IL-2, but not IL-12, stimulation.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
7	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	_
19	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	upon	upon	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8984
# text = Analysis of the accumulation of mRNA-encoding members of the AP-1 transcription factor family demonstrated that c-fos and junB are also expressed upon stimulation of NK and T cells with IL-2, but not IL-12, whereas expression of c-jun and junD is not modified by either cytokine.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	junB	junb	PROPN	NNP	Number=Sing	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	upon	upon	ADP	IN	_	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	IL	Il	SYM	$	_	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	whereas	whereas	SCONJ	IN	_	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
49	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	junD	jund	NOUN	NN	Number=Sing	_	_	_	_
52	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	not	not	PART	RB	_	_	_	_	_
54	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	either	either	DET	DT	_	_	_	_	_
57	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8985
# text = Accordingly, increased AP-1 DNA-binding activity and AP-1-dependent transcriptional activity were detected exclusively in IL-2-stimulated cells.
1	Accordingly	accordingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	exclusively	exclusively	ADV	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8986
# text = Analysis of the expression of genes reported to regulate cytokine-induced proliferation demonstrated that both IL-2 and IL-12 induce c-myc mRNA accumulation in NK and T cells, whereas only IL-2 induces bcl-2 expression.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	12	12	NUM	CD	NumType=Card	_	_	_	_
24	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
25	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	_
26	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
27	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	whereas	whereas	SCONJ	IN	_	_	_	_	_
35	only	only	ADV	RB	_	_	_	_	_
36	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
40	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8987
# text = Our data provide the first demonstration that IL-12-mediated activation of T and NK cells does not involve expression of members of the immediate-early activation genes family (egr-1, c-fos, and junB), AP-1 transcriptional activity, or bcl-2 expression.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	members	member	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	junB	junb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
48	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	or	or	CCONJ	CC	_	_	_	_	_
51	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	2	2	NUM	CD	NumType=Card	_	_	_	_
54	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8988
# text = This indicates that functional differences observed in IL-2- and IL-12-stimulated cells may depend, at least in part, on differential gene regulation.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	at	at	ADV	RB	_	_	_	_	_
23	least	least	ADV	RBS	Degree=Sup	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8989
# text = Document 0030011652 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011652	0030011652	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8990
# text = Regulation of gene expression at early stages of B-cell and T-cell differentiation.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8991
# text = The expression of distinct sets of genes at different stages of B-lymphocyte and T-lymphocyte differentiation is controlled at the level of transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8992
# text = A number of recent studies have described interactions between transcription factors in lymphocytes that provide new insights into mechanisms regulating gene expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
17	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
20	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8993
# text = These mechanisms include the assembly of higher order nucleoprotein complexes and other protein-protein interactions that enhance the functional specificity of transcriptional regulators in lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
8	order	order	NOUN	NN	Number=Sing	_	_	_	_
9	nucleoprotein	nucleoprotein	NOUN	NN	Number=Sing	_	_	_	_
10	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	enhance	enhance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 8994
# text = Document 0030011659 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011659	0030011659	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 8995
# text = Oleic acid inhibits endothelial activation :
1	Oleic	Oleic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 8996
# text = A direct vascular antiatherogenic mechanism of a nutritional component in the mediterranean diet.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
4	antiatherogenic	antiatherogenic	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	nutritional	nutritional	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mediterranean	mediterranean	ADJ	JJ	Degree=Pos	_	_	_	_
13	diet	diet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 8997
# text = Because oleic acid is implicated in the antiatherogenic effects attributed to the Mediterranean diet, we investigated whether this fatty acid can modulate endothelial activation, ie, the concerted expression of gene products involved in leukocyte recruitment and early atherogenesis.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	oleic	oleic	ADJ	JJ	Degree=Pos	_	_	_	_
3	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	antiatherogenic	antiatherogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Mediterranean	Mediterranean	PROPN	NNP	Number=Sing	_	_	_	_
14	diet	diet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	whether	whether	SCONJ	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
21	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
24	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	concerted	concerted	ADJ	JJ	Degree=Pos	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	products	product	NOUN	NNS	Number=Plur	_	_	_	_
35	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
38	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
41	atherogenesis	atherogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8998
# text = We incubated sodium oleate with human umbilical vein endothelial cells for 0 to 72 hours, followed by coincubation of oleate with human recombinant tumor necrosis factor, interleukin (IL)-1alpha, IL-1beta, IL-4, Escherichia coli lipopolysaccharide (LPS), or phorbol 12-myristate 13-acetate for a further 6 to 24 hours.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	incubated	incubate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
4	oleate	oleate	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
8	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
9	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	0	0	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	72	72	NUM	CD	NumType=Card	_	_	_	_
15	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	coincubation	coincubation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
46	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
47	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	or	or	CCONJ	CC	_	_	_	_	_
53	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
54	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
57	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
60	for	for	ADP	IN	_	_	_	_	_
61	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
63	6	6	NUM	CD	NumType=Card	_	_	_	_
64	to	to	ADP	IN	_	_	_	_	_
65	24	24	NUM	CD	NumType=Card	_	_	_	_
66	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8999
# text = The endothelial expression of vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and intercellular adhesion molecule-1 was monitored by cell surface enzyme immunoassays or flow cytometry, and steady-state levels of VCAM-1 mRNA were assessed by Northern blot analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	E-	E-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
23	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
31	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
32	immunoassays	immunoassay	NOUN	NNS	Number=Plur	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
35	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	state	state	NOUN	NN	Number=Sing	_	_	_	_
41	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	VCAM	VCAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
47	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
51	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
52	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9000
# text = At 10 to 100 micromol/L for >24 hours, oleate inhibited the expression of all adhesion molecules tested.
1	At	at	ADP	IN	_	_	_	_	_
2	10	10	NUM	CD	NumType=Card	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	100	100	NUM	CD	NumType=Card	_	_	_	_
5	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	>	>	SYM	NFP	_	_	_	_	SpaceAfter=No
8	24	24	NUM	CD	NumType=Card	_	_	_	_
9	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	oleate	oleate	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
19	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9001
# text = After a 72-hour incubation with oleate and a further 16-hour incubation with oleate plus 1 microg/mL LPS, VCAM-1 expression was reduced by >40% compared with control.
1	After	after	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	72	72	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
6	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
12	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
15	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
18	plus	plus	CCONJ	CC	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	microg	microg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	mL	mL	PROPN	NNP	Number=Sing	_	_	_	_
23	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	>	>	SYM	$	_	_	_	_	SpaceAfter=No
33	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	%	%	SYM	NN	Number=Sing	_	_	_	_
35	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9002
# text = Adhesion of monocytoid U937 cells to LPS-treated endothelial cells was reduced concomitantly.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	concomitantly	concomitantly	ADV	RB	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9003
# text = Oleate also produced a quantitatively similar reduction of VCAM-1 mRNA levels on Northern blot analysis and inhibited nuclear factor-kappaB activation on electrophoretic mobility shift assays.
1	Oleate	Oleate	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	quantitatively	quantitatively	ADV	RB	_	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
16	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
17	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
27	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
28	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
29	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9004
# text = Incubation of endothelial cells with oleate for 72 hours decreased the relative proportions of saturated (palmitic and stearic) acids in total cell lipids and increased the proportions of oleate in total cell lipids without significantly changing the relative proportions of polyunsaturated fatty acids.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	72	72	NUM	CD	NumType=Card	_	_	_	_
9	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
13	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	saturated	saturate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	palmitic	palmitic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	stearic	stearic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lipids	lipid	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	oleate	oleate	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lipids	lipid	NOUN	NNS	Number=Plur	_	_	_	_
36	without	without	SCONJ	IN	_	_	_	_	_
37	significantly	significantly	ADV	RB	_	_	_	_	_
38	changing	change	VERB	VBG	VerbForm=Ger	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
41	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	polyunsaturated	polyunsaturate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
45	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9005
# text = Although less potent than polyunsaturated fatty acids in inhibiting endothelial activation, oleic acid may contribute to the prevention of atherogenesis through selective displacement of saturated fatty acids in cell membrane phospholipids and a consequent modulation of gene expression for molecules involved in monocyte recruitment.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	less	less	ADJ	JJS	Degree=Sup	_	_	_	_
3	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
4	than	than	ADP	IN	_	_	_	_	_
5	polyunsaturated	polyunsaturate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
7	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	oleic	oleic	ADJ	JJ	Degree=Pos	_	_	_	_
14	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
24	displacement	displacement	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	saturated	saturate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
28	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
32	phospholipids	phospholipid	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
36	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
42	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
45	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9006
# text = Document 0030011660 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011660	0030011660	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9007
# text = Transcriptional activation of human zeta 2 globin promoter by the alpha globin regulatory element (HS-40): functional role of specific nuclear factor-DNA complexes.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	globin	globin	ADP	IN	_	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HS	HS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9008
# text = We studied the functional interaction between human embryonic zeta 2 globin promoter and the alpha globin regulatory element (HS-40) located 40 kb upstream of the zeta 2 globin gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
9	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	globin	globin	ADP	IN	_	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HS	HS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	40	40	NUM	CD	NumType=Card	_	_	_	_
26	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
27	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9009
# text = It was shown by transient expression assay that HS-40 behaved as an authentic enhancer for high-level zeta 2 globin promoter activity in K562 cells, an erythroid cell line of embryonic and/or fetal origin.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	HS	HS	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	40	40	NUM	CD	NumType=Card	_	_	_	_
12	behaved	behave	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	authentic	authentic	ADJ	JJ	Degree=Pos	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	K562	K562	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	embryonic	embryonic	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	or	or	CCONJ	CC	_	_	_	_	_
39	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
40	origin	origin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9010
# text = Although sequences located between -559 and -88 of the zeta 2 globin gene were dispensable for its expression on enhancerless plasmids, they were required for the HS-40 enhancer-mediated activity of the zeta 2 globin promoter.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	559	559	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	88	88	NUM	CD	NumType=Card	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	enhancerless	enhancerless	ADJ	JJ	Degree=Pos	_	_	_	_
23	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	HS	HS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	40	40	NUM	CD	NumType=Card	_	_	_	_
33	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
40	2	2	NUM	CD	NumType=Card	_	_	_	_
41	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9011
# text = Site-directed mutagenesis demonstrated that this HS-40 enhancer-zeta 2 globin promoter interaction is mediated by the two GATA-1 factor binding motifs located at -230 and -104, respectively.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	mutagenesis	mutagenesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	HS	HS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	40	40	NUM	CD	NumType=Card	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-zeta	-zeta	NOUN	NN	Number=Sing	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
28	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	230	230	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	104	104	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9012
# text = The functional domains of HS-40 were also mapped.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	40	40	NUM	CD	NumType=Card	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9013
# text = Bal 31 deletion mapping data suggested that one GATA-1 motif, one GT motif, and two NF-E2/AP1 motifs together formed the functional core of HS-40 in the erythroid-specific activation of the zeta 2 globin promoter.
1	Bal	bal	PROPN	NNP	Number=Sing	_	_	_	_
2	31	31	NUM	CD	NumType=Card	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	GT	Gt	NOUN	NN	Number=Sing	_	_	_	_
16	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
24	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
25	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
26	together	together	ADV	RB	_	_	_	_	_
27	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
30	core	core	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	40	40	NUM	CD	NumType=Card	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9014
# text = Site-directed mutagenesis further demonstrated that the enhancer function of one of the two NF-E2/AP1 motifs of HS-40 is mediated through its binding to NF-E2 but not AP1 transcription factor.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	mutagenesis	mutagenesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	further	further	ADV	RB	_	_	_	_	_
6	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	E2/	E2/	SYM	SYM	_	_	_	_	SpaceAfter=No
19	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
20	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	40	40	NUM	CD	NumType=Card	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9015
# text = Finally, we did genomic footprinting of the HS-40 enhancer region in K562 cells, adult nucleated erythroblasts, and different nonerythroid cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HS	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	40	40	NUM	CD	NumType=Card	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	K562	K562	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	nucleated	nucleate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	nonerythroid	nonerythroid	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9016
# text = All sequence motifs within the functional core of HS-40, as mapped by transient expression analysis, appeared to bind a nuclear factor(s) in living K562 cells but not in nonerythroid cells.
1	All	all	DET	DT	_	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
4	within	within	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	core	core	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	s	s	X	AFX	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	SCONJ	IN	_	_	_	_	_
30	living	live	VERB	VBG	VerbForm=Ger	_	_	_	_
31	K562	K562	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	nonerythroid	nonerythroid	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9017
# text = On the other hand, only one of the apparently nonfunctional sequence motifs was bound with factors in vivo.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	apparently	apparently	ADJ	JJ	Degree=Pos	_	_	_	_
11	nonfunctional	nonfunctional	ADJ	JJ	Degree=Pos	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9018
# text = In comparison to K562, nucleated erythroblasts from adult human bone marrow exhibited a similar but nonidentical pattern of nuclear factor binding in vivo at the HS-40 region.
1	In	in	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	K562	K562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	nucleated	nucleate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
12	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
13	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	nonidentical	nonidentical	ADJ	JJ	Degree=Pos	_	_	_	_
18	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	40	40	NUM	CD	NumType=Card	_	_	_	_
30	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9019
# text = These data suggest that transcriptional activation of human embryonic zeta 2 globin gene and the fetal/adult alpha globin genes is mediated by erythroid cell-specific and developmental stage-specific nuclear factor-DNA complexes which form at the enhancer (HS-40) and the globin promoters.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
10	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	ADP	IN	_	_	_	_	_
20	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	erythroid	erythroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
31	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
38	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	form	form	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	at	at	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	HS	HS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
52	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9020
# text = Document 0030011668 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011668	0030011668	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9021
# text = Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression.
1	Neuronal	Neuronal	ADJ	JJ	Degree=Pos	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	type	type	NOUN	NN	Number=Sing	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
7	oxide	oxide	ADJ	JJ	Degree=Pos	_	_	_	_
8	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
9	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	immunologic	immunologic	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
21	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
22	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9022
# text = Nitric oxide subserves diverse physiologic roles in the nervous system.
1	Nitric	Nitric	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
3	subserves	subserve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
5	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
6	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
10	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9023
# text = NO is produced from at least three different NO synthase (NOS) isoforms: neuronal NOS (nNOS), endothelial NOS, and immunologic NOS (iNOS).
1	NO	no	DET	DT	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	at	at	ADV	RB	_	_	_	_	_
6	least	least	ADV	RBS	Degree=Sup	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	NO	no	DET	DT	_	_	_	_	_
10	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	NOS	Nos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	neuronal	neuronal	ADJ	JJ	Degree=Pos	_	_	_	_
17	NOS	Nos	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	nNOS	nNOS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	NOS	no	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
27	NOS	NOS	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	iNOS	iNOS	X	ADD	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9024
# text = We show that nNOS is the predominant isoform constitutively expressed in glia.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	nNOS	nNOS	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
8	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
9	constitutively	constitutively	ADV	RB	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	glia	glia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9025
# text = NO derived from nNOS in glia inhibits the transcription factor nuclear factor kappaB (NF kappaB) as NOS inhibitors enhance basal NF kappaB activation.
1	NO	no	INTJ	UH	_	_	_	_	_
2	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	nNOS	nNOS	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	glia	glia	PROPN	NNP	Number=Sing	_	_	_	_
7	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	NOS	NOS	ADJ	JJ	Degree=Pos	_	_	_	_
20	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
21	enhance	enhance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9026
# text = Pyrrolidine dithiocarbamate (PDTC) is an inhibitor of NF kappaB in most cells; however, we show that PDTC is also a potent scavenger of NO through formation of mononitrosyl iron complexes with PDTC.
1	Pyrrolidine	Pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
2	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
26	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NO	no	DET	DT	_	_	_	_	_
29	through	through	ADP	IN	_	_	_	_	_
30	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	mononitrosyl	mononitrosyl	NOUN	NN	Number=Sing	_	_	_	_
33	iron	iron	NOUN	NN	Number=Sing	_	_	_	_
34	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9027
# text = In Jurkat cells, a human T-cell lymphoma cell line, tumor necrosis factor-alpha (TNF-alpha) induces NF kappaB activation that is inhibited by PDTC.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9028
# text = Contrary to the results in Jurkat cells, PDTC did not inhibit tumor necrosis factor-alpha-induced NF kappaB activation in astrocytes; instead PDTC itself induces NF kappaB activation in astrocytes, and this may be related to scavenging of endogenously produced NO by the PDTC iron complex.
1	Contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
10	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-alpha-induced	-alpha-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	instead	instead	ADV	RB	_	_	_	_	_
24	PDTC	Pdtc	NOUN	NN	Number=Sing	_	_	_	_
25	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
38	to	to	SCONJ	IN	_	_	_	_	_
39	scavenging	scavenging	VERB	VBG	VerbForm=Ger	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	endogenously	endogenously	ADV	RB	_	_	_	_	_
42	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	NO	no	ADV	RB	_	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
47	iron	iron	ADJ	JJ	Degree=Pos	_	_	_	_
48	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9029
# text = In astrocytes PDTC also dramatically induces the NF kappaB-dependent enzyme, iNOS, supporting the physiologic relevance of endogenous NO regulation of NF kappaB.
1	In	in	ADP	IN	_	_	_	_	_
2	astrocytes	astrocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	PDTC	Pdtc	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	dramatically	dramatically	ADV	RB	_	_	_	_	_
6	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	iNOS	ino	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
19	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
22	NO	no	DET	DT	_	_	_	_	_
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9030
# text = NF kappaB activation in glia from mice lacking nNOS responds more rapidly to PDTC compared with astrocytes from wild-type mice.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
2	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	glia	glia	NOUN	NN	Number=Sing	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
9	nNOS	nnos	NOUN	NNS	Number=Plur	_	_	_	_
10	responds	responds	NOUN	NNS	Number=Plur	_	_	_	_
11	more	more	ADV	RBR	_	_	_	_	_
12	rapidly	rapidly	ADV	RB	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
15	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9031
# text = Our data suggest that nNOS in astrocytes regulates NF kappaB activity and iNOS expression, and indicate a novel regulatory role for nNOS in tonically suppressing central nervous system, NF kappaB-regulated genes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	nNOS	nnos	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	iNOS	inos	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	nNOS	nnos	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	SCONJ	IN	_	_	_	_	_
25	tonically	tonically	ADV	RB	_	_	_	_	_
26	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
27	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
28	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
29	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9032
# text = Document 0030011669 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011669	0030011669	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9033
# text = Inhibition of HIV-1 latency reactivation by dehydroepiandrosterone (DHEA) and an analog of DHEA.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
7	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	dehydroepiandrosterone	dehydroepiandrosterone	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	DHEA	DHEA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	analog	analog	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	DHEA	DHEA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9034
# text = The initial infection with human immunodeficiency virus type 1 (HIV-1) in most individuals usually results in the establishment of a latent or chronic infection before eventual progression toward acquired immunodeficiency syndrome.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
3	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	X	LS	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
17	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
18	usually	usually	ADV	RB	_	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	establishment	establishment	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
28	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
29	before	before	ADP	IN	_	_	_	_	_
30	eventual	eventual	ADJ	JJ	Degree=Pos	_	_	_	_
31	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
32	toward	toward	ADP	IN	_	_	_	_	_
33	acquired	acquire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
35	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9035
# text = HIV-1 can also establish a latent or persistent infection in some T cell lines that show minimal constitutive virus expression.
1	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	some	some	DET	DT	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
20	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9036
# text = However, activation of the T cell lines leading to enhanced HIV-1 replication can be induced by antigens, mitogens, and cytokines (tumor necrosis factor alpha [TNF-alpha], interleukin 1, and interleukin-2).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	T	T	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
28	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	interleukin	interleukin	ADV	RB	_	_	_	_	_
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9037
# text = Various gene products from other viruses (HTLV-1, HSV, EBV, CMV, HBV, and HHV-6) can also enhance HIV-1 long terminal repeat (LTR)-driven reporter gene activity.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	products	product	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
6	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	HSV	HSV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	HBV	HBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	HHV	HHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	6	6	X	LS	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	also	also	ADV	RB	_	_	_	_	_
27	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
28	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
32	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
33	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
38	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9038
# text = On the basis of these observations, it has been proposed that reactivation of latent HIV-1 harbored in chronically infected T lymphocytes, monocytes, or macrophages plays an important role in the pathogenesis of AIDS.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	observations	observation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	harbored	harbor	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	chronically	chronically	ADV	RB	_	_	_	_	_
22	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
30	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
33	role	role	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9039
# text = So far, there are no drugs or therapy available that can provide protection against HIV-1 latency reactivation.
1	So	so	ADV	RB	_	_	_	_	_
2	far	far	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	there	there	PRON	EX	_	_	_	_	_
5	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
10	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
14	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
15	against	against	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
20	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9040
# text = ACH-2, derived from a human T cell line (CEM), is chronically infected with HIV-1, with low levels of constitutive virus expression.
1	ACH	ACh	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	chronically	chronically	ADV	RB	_	_	_	_	_
18	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
29	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9041
# text = ACH-2 can be converted to productive infection by stimulation of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), mitogen or cytokines (TNF-alpha), or infection with HSV.
1	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	converted	convert	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	productive	productive	VERB	VB	VerbForm=Inf	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	HSV	HSV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9042
# text = Therefore the ACH-2 cell line is a good candidate for studying the effects of drugs on HIV-1 activation.
1	Therefore	therefore	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	good	good	ADJ	JJ	Degree=Pos	_	_	_	_
11	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9043
# text = Previously, we have reported that DHEA and synthetic analogs of DHEA can be modest inhibitors of HIV-1 IIIB replication in phytohemagglutinin-stimulated peripheral blood lymphocyte cultures.
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	DHEA	DHEa	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
10	analogs	analog	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	DHEA	DHEA	PROPN	NNP	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	modest	modest	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	IIIB	Iiib	NOUN	NN	Number=Sing	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
28	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
29	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
30	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9044
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9045
# text = Document 0030011670 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011670	0030011670	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9046
# text = Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	3q21	3q21	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	intergenic	intergenic	ADJ	JJ	Degree=Pos	_	_	_	_
12	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
13	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	ecotropic	ecotropic	ADJ	JJ	Degree=Pos	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9047
# text = We have identified a novel gene, GR6, located within the leukemia breakpoint region of 3q21, that is normally expressed in early fetal development but not in adult peripheral blood.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	GR6	Gr6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	breakpoint	breakpoint	NOUN	NN	Number=Sing	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	3q21	3q21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	normally	normally	ADV	RB	_	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
25	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
31	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
32	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9048
# text = GR6 is activated in the UCSD-AML1 cell line and in a leukemic sample, both of which carry a t(3;3)(q21;q26).
1	GR6	Gr6	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	UCSD	Ucsd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	AML1	Aml1	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	sample	sample	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	carry	carry	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	3;3	3;3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	q21;q26	q21;q26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9049
# text = In UCSD-AML1, we have also identified fusion transcripts between the ecotropic viral insertion site I (EVI1) gene in 3q26 and GR6 and between EVI1 and Ribophorin I that maps 30 kb telomeric to GR6 in 3q21.
1	In	in	ADP	IN	_	_	_	_	_
2	UCSD	UCSD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ecotropic	ecotropic	ADJ	JJ	Degree=Pos	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	EVI1	EVI1	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	3q26	3q26	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	GR6	GR6	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	between	between	ADP	IN	_	_	_	_	_
29	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Ribophorin	Ribophorin	PROPN	NNP	Number=Sing	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	maps	map	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	30	30	NUM	CD	NumType=Card	_	_	_	_
36	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
37	telomeric	telomeric	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	GR6	GR6	NUM	CD	NumType=Card	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	3q21	3q21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9050
# text = All fusions splice the 5' ends of the 3q21 genes into exon 2 of the EVI1 gene, an event that is similar to the normal intergenic splicing of MDS1-EVI1 and to those previously documented in leukemias with t(3;21) and t(3;12), in which acute myelogenous leukemia 1-EVI1 fusions and ETV6-EVI1 fusions, respectively, occur.
1	All	all	DET	DT	_	_	_	_	_
2	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	_
3	splice	splice	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	's	PUNCT	``	_	_	_	_	_
7	ends	end	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	3q21	3q21	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	event	event	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
28	intergenic	intergenic	ADJ	JJ	Degree=Pos	_	_	_	_
29	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	MDS	Md	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	EVI1	EVI1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
38	previously	previously	ADV	RB	_	_	_	_	_
39	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	leukemias	leukemias	NOUN	NNS	Number=Plur	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	t(	t(	SYM	NFP	_	_	_	_	SpaceAfter=No
44	3;21	3;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	3;12	3;12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	which	which	PRON	WDT	PronType=Rel	_	_	_	_
54	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
55	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
56	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
57	1-	1-	SYM	SYM	_	_	_	_	SpaceAfter=No
58	EVI1	Evi1	NUM	CD	NumType=Card	_	_	_	_
59	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	ETV6	ETV6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	-EVI1	-evi1	NOUN	NN	Number=Sing	_	_	_	_
63	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
66	,	,	PUNCT	,	_	_	_	_	_
67	occur	occur	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9051
# text = The Ribophorin I-EVI1 fusion in particular may be a common occurrence in t(3;3).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ribophorin	Ribophorin	PROPN	NNP	Number=Sing	_	_	_	_
3	I	I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	occurrence	occurrence	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9052
# text = Document 0030011677 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011677	0030011677	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9053
# text = Immortalization of CD4(+) and CD8(+)
1	Immortalization	Immortalization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	(+)	(+)	SYM	NFP	_	_	_	_	_

# sent_id = 9054
# text = T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
12	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
17	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
18	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9055
# text = The human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator Tax has been demonstrated to have transforming activity in multiple cell culture and transgenic-mouse models.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
18	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
19	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
24	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	transgenic	transgenic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
34	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9056
# text = In addition to activating transcription from the viral long terminal repeat (LTR) through the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors, Tax activates the expression of multiple cellular promoters through the NF-kappaB pathway of transcriptional activation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	SCONJ	IN	_	_	_	_	_
4	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
9	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
18	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
38	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
43	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
44	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
45	through	through	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
50	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9057
# text = The Tax mutants M22 and M47 have previously been demonstrated to selectively abrogate the ability of Tax to activate transcription through the NF-kappaB or CREB/ATF pathway, respectively.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
4	M22	M22	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	M47	M47	NOUN	NN	Number=Sing	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	previously	previously	ADV	RB	_	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	selectively	selectively	ADV	RB	_	_	_	_	_
13	abrogate	abrogate	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9058
# text = These mutations were introduced in the tax gene of the ACH functional molecular clone of HTLV-1, and virus produced from the mutant ACH clones was examined for the ability to replicate and immortalize primary human lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	ACH	ACh	DET	DT	_	_	_	_	_
12	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
13	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
14	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
26	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	_
27	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	immortalize	immortalize	VERB	VB	VerbForm=Inf	_	_	_	_
37	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9059
# text = While virus derived from the clone containing the M47 mutation retained the ability to immortalize T lymphocytes, the M22 mutant lost the ability to immortalize infected cells.
1	While	while	SCONJ	IN	_	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
3	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
7	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	M47	M47	NOUN	NN	Number=Sing	_	_	_	_
10	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
11	retained	retain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	immortalize	immortalize	VERB	VB	VerbForm=Inf	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	M22	M22	PROPN	NNP	Number=Sing	_	_	_	_
21	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
22	lost	lose	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	immortalize	immortalize	VERB	VB	VerbForm=Inf	_	_	_	_
27	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9060
# text = These results indicate that activation of the CREB/ATF pathway by Tax is dispensable for the immortalization of T cells by HTLV-1, whereas activation of the NF-kappaB pathway may be critical.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	whereas	whereas	SCONJ	IN	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9061
# text = Document 0030011679 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011679	0030011679	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9062
# text = Human immunodeficiency virus type 1 long terminal repeat quasispecies differ in basal transcription and nuclear factor recruitment in human glial cells and lymphocytes.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	repeat	repeat	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	quasispecies	quasispecy	NOUN	NNS	Number=Plur	_	_	_	_
10	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9063
# text = The generation of genomic diversity during the course of infection has the potential to affect all aspects of HIV-1 replication, including expression of the proviral genome.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
5	diversity	diversity	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	course	course	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
29	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9064
# text = To gain a better understanding of the impact of long terminal repeat (LTR) sequence diversity on LTR-directed gene expression in cells of the central nervous system (CNS) and immune system, we amplified and cloned LTRs from proviral DNA in HIV-1-infected peripheral blood.
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
5	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	impact	impact	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	diversity	diversity	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	LTR-	LTR-	X	AFX	_	_	_	_	SpaceAfter=No
20	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
28	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
29	system	system	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	CNS	Cn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
35	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
38	amplified	amplify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
42	from	from	ADP	IN	_	_	_	_	_
43	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
52	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9065
# text = Sequence analysis of nineteen LTRs cloned from 2 adult and 3 pediatric patients revealed an average of 33 nucleotide changes (with respect to the sequence of the LAI LTR) within the 455-bp U3 region.
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nineteen	nineteen	NUM	CD	NumType=Card	_	_	_	_
5	LTRs	LTRs	NOUN	NNS	Number=Plur	_	_	_	_
6	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	pediatric	pediatric	ADJ	JJ	Degree=Pos	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	average	average	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	33	33	NUM	CD	NumType=Card	_	_	_	_
19	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
20	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	with	with	ADP	IN	_	_	_	_	_
23	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	_
30	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	within	within	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	455	455	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
37	U3	U3	NUM	CD	NumType=Card	_	_	_	_
38	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9066
# text = Transient expression analyses in cells of neuroglial and lymphocytic origin demonstrated that some of these LTRs had activities which varied significantly from the LAI LTR in U-373 MG cells (an astrocytoma cell line) as well as in Jurkat cells (a CD4-positive lymphocyte cell line).
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	neuroglial	neuroglial	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
11	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	some	some	DET	DT	_	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
17	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	varied	vary	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	_
25	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	373	373	NUM	CD	NumType=Card	_	_	_	_
30	MG	Mg	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	astrocytoma	astrocytoma	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	as	as	ADV	RB	_	_	_	_	_
39	well	well	ADV	RB	Degree=Pos	_	_	_	_
40	as	as	ADP	IN	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
49	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9067
# text = While LTRs which demonstrated the highest activities in U-373 MG cells also yielded high activities in Jurkat cells, the LTRs were generally more active in Jurkat cells when compared to the LAI LTR.
1	While	while	SCONJ	IN	_	_	_	_	_
2	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
7	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	373	373	NUM	CD	NumType=Card	_	_	_	_
12	MG	Mg	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	yielded	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTRs	LTRs	PROPN	NNPS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	generally	generally	ADV	RB	_	_	_	_	_
26	more	more	ADV	RBR	_	_	_	_	_
27	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	when	when	ADV	WRB	PronType=Int	_	_	_	_
32	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	_
36	LTR.	LTR.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 9068
# text = Differences in LTR sequence also resulted in differences in transcription factor recruitment to cis-acting sites within the U3 region of the LTR, as demonstrated by electrophoretic mobility shift assays.
1	Differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
15	-acting	-act	ADJ	JJ	Degree=Pos	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	U3	U3	NOUN	NN	Number=Sing	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
29	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
30	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
31	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9069
# text = In particular, naturally occurring sequence variation impacted transcription factor binding to an activating transcription factor/cAMP response element binding (ATF/CREB) binding site (located between the LEF-1 and distal NF-kappaB transcription factor binding sites) that we identified in previous studies of the HIV-1 LTR.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	naturally	naturally	ADV	RB	_	_	_	_	_
5	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
8	impacted	impact	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	LEF	LEF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	that	that	PRON	WDT	PronType=Rel	_	_	_	_
47	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
48	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
51	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	1	1	NUM	CD	NumType=Card	_	_	_	_
57	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9070
# text = These findings suggest that LTR sequence changes can significantly affect basal LTR function and transcription factor recruitment, which may, in turn, alter the course of viral replication in cells of CNS and immune system origin.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	significantly	significantly	ADV	RB	_	_	_	_	_
10	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
11	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	course	course	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	CNS	Cn	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
37	system	system	NOUN	NN	Number=Sing	_	_	_	_
38	origin	origin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9071
# text = Document 0030011683 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011683	0030011683	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9072
# text = GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.
1	GATA	GATa	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	associate	associate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	class	class	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	bodies	body	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9073
# text = The nuclear distribution of GATA transcription factors in murine haemopoietic cells was examined by indirect immunofluorescence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
10	haemopoietic	haemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9074
# text = Specific bright foci of GATA-1 fluorescence were observed in erythroleukaemia cells and primary murine erythroblasts and megakaryocytes, in addition to diffuse nucleoplasmic localization.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	bright	bright	ADJ	JJ	Degree=Pos	_	_	_	_
3	foci	foci	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	erythroleukaemia	erythroleukaemia	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
17	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	diffuse	diffuse	VERB	VB	VerbForm=Inf	_	_	_	_
25	nucleoplasmic	nucleoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
26	localization	localization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9075
# text = These foci, which were preferentially found adjacent to nucleoli or at the nuclear periphery, did not represent sites of active transcription or binding of GATA-1 to consensus sites in the beta-globin loci.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	foci	foci	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	preferentially	preferentially	ADV	RB	_	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	nucleoli	nucleoli	PRON	PRP	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	periphery	periphery	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
38	loci	loci	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9076
# text = Immunoelectron microscopy demonstrated the presence of intensely labelled structures likely to represent the GATA-1 foci seen by immunofluorescence.
1	Immunoelectron	Immunoelectron	PROPN	NNP	Number=Sing	_	_	_	_
2	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	intensely	intensely	ADV	RB	_	_	_	_	_
8	labelled	labell	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	structures	structure	NOUN	NNS	Number=Plur	_	_	_	_
10	likely	likely	ADV	RB	_	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	foci	foci	NOUN	NN	Number=Sing	_	_	_	_
18	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9077
# text = The GATA-1 nuclear bodies differed from previously described nuclear structures and there was no co-localization with nuclear antigens involved in RNA processing or other ubiquitous (Spl, c-Jun and TBP) or haemopoietic (NF-E2) transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	bodies	body	NOUN	NNS	Number=Plur	_	_	_	_
7	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	previously	previously	ADV	RB	_	_	_	_	_
10	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	structures	structure	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	there	there	PRON	EX	_	_	_	_	_
15	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	no	no	DET	DT	_	_	_	_	_
17	co	co	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-localization	-localization	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
22	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
25	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	Spl	Spl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	TBP	TBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	haemopoietic	haemopoietic	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9078
# text = Interestingly, GATA-2 and GATA-3 proteins also localized to the same nuclear bodies in cell lines co-expressing GATA-1 and -2 or GATA-1 and -3 gene products.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	localized	localize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	bodies	body	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	co-expressing	co-expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
22	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	3	3	NUM	CD	NumType=Card	_	_	_	_
35	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
36	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9079
# text = This pattern of distribution is, thus far, unique to the GATA transcription factors and suggests a protein-protein interaction with other components of the nuclear bodies via the GATA zinc finger domain.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	thus	thus	ADV	RB	_	_	_	_	_
8	far	far	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
24	components	component	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	bodies	body	NOUN	NNS	Number=Plur	_	_	_	_
29	via	via	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
32	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
33	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
34	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9080
# text = Document 0030011685 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011685	0030011685	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9081
# text = Inhibition of NF-kappa B by sodium salicylate and aspirin [see comments]
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
9	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
12	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
14	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9082
# text = The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
23	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
32	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
33	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
44	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
48	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9083
# text = The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
4	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
5	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	further	further	ADV	RB	_	_	_	_	_
19	explains	explain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	action	action	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9084
# text = This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	therefore	therefore	ADV	RB	_	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9085
# text = Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
1	Sodium	sodium	PROPN	NNP	Number=Sing	_	_	_	_
2	salicylate	salicylate	VERB	VB	VerbForm=Inf	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	aspirin	aspirin	VERB	VB	VerbForm=Inf	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	transfected	transfect	ADJ	JJ	Degree=Pos	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9086
# text = Document 0030011687 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011687	0030011687	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9087
# text = Costimulation of peripheral blood T cell activation by human endothelial cells.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	T	t	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9088
# text = Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1.
1	Enhanced	enhance	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
12	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	_
16	content	content	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9089
# text = Endothelial cells (EC) act as APC for resting PBL in vitro, and may have important roles in vivo in the pathogenesis of allograft rejection and delayed hypersensitivity.
1	Endothelial	Endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	act	act	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	APC	APC	PROPN	NNP	Number=Sing	_	_	_	_
9	for	for	SCONJ	IN	_	_	_	_	_
10	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
19	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	allograft	allograft	NOUN	NN	Number=Sing	_	_	_	_
27	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	_
30	hypersensitivity	hypersensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9090
# text = We previously reported that human umbilical vein EC provide costimulatory signals to PHA-stimulated PBL via CD2:lymphocyte function-associated Ag-3 and an unidentified ligand pair, resulting in a three- to eight-fold enhancement of IL-2 production.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
7	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
9	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
10	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	CD2	CD2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
20	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Ag	ag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
30	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
31	pair	pair	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	eight	eight	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
42	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	2	2	NUM	CD	NumType=Card	_	_	_	_
47	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9091
# text = The physiologic relevance of this increase was demonstrated by the proliferative advantage provided by EC to PBL suboptimally stimulated with mAb OKT3.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
3	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
13	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
18	suboptimally	suboptimally	ADV	RB	_	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
22	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9092
# text = We now report that EC costimulation causes increased levels of IL-2 mRNA as a result of increased IL-2 transcription in PBL.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
7	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	result	result	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9093
# text = We therefore examined the effects of EC on T cell nuclear factors known to regulate IL-2 transcription, including c-jun and c-fos-two components of the transcription factor AP-1, NFAT, and others.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	components	component	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9094
# text = PBL constitutively express c-jun transcripts, and the level of c-jun mRNA is not altered by PHA activation in the absence or presence of EC.
1	PBL	pBl	AUX	MD	VerbForm=Fin	_	_	_	_
2	constitutively	constitutively	ADV	RB	_	_	_	_	_
3	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	level	level	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	PHA	PHa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9095
# text = In contrast, c-fos mRNA is absent from resting T cells and is induced on PHA activation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	SCONJ	IN	_	_	_	_	_
10	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	PHA	PHa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9096
# text = EC alone do not induce c-fos mRNA but augment the level of c-fos mRNA in PHA-activated
1	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
2	alone	alone	ADV	RB	_	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
8	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	augment	augment	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
17	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 9097
# text = T cells by 3- to 10-fold.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9098
# text = This effect is largely independent of the CD2:lymphocyte function-associated Ag-3 pathway.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	largely	largely	ADV	RB	_	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	Ag	ag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9099
# text = Gel-shift analysis reveals the constitutive presence of nuclear factors in resting PBL that bind to the proximal AP-1 site of the IL-2 promoter and that contain immunoreactive c-Jun but not c-Fos protein.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	reveals	reveal	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
34	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	c	class	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	Fos	Fos	ADJ	JJ	Degree=Pos	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9100
# text = In contrast, AP-1 from PHA-activated cells contains c-Jun and low levels of c-Fos.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9101
# text = Strikingly, costimulation with EC results in a dramatic increase (up to 15-fold) in the c-Fos content of AP-1.
1	Strikingly	strikingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	up	up	ADP	IN	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
23	content	content	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9102
# text = Levels of other nuclear factors involved in IL-2 regulation were not altered by EC, although NFAT-DNA complexes migrated at a slightly different mobility.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
23	migrated	migrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	slightly	slightly	ADV	RB	_	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9103
# text = In summary, our data suggest that changes in the composition of transcription factor AP-1 is a key molecular mechanism for increasing IL-2 transcription and may underlie the phenomenon of costimulation by EC.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	SCONJ	IN	_	_	_	_	_
24	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9104
# text = Document 0030011690 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011690	0030011690	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9105
# text = c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	target	target	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	pentoxifylline	pentoxifylline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9106
# text = The possible clinical use of the methyl xanthine derivative, pentoxifylline (PF), for the treatment of T cell-dependent diseases is being noted with increasing interest.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
3	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
4	use	use	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	methyl	methyl	ADJ	JJ	Degree=Pos	_	_	_	_
8	xanthine	xanthine	NOUN	NN	Number=Sing	_	_	_	_
9	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	pentoxifylline	pentoxifylline	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PF	PF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
27	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	SCONJ	IN	_	_	_	_	_
29	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
30	interest	interest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9107
# text = In this paper, we studied the molecular consequences of PF treatment during lymphocyte activation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
9	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PF	Pf	NOUN	NN	Number=Sing	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9108
# text = We found that in T cells, anti-CD3-induced c-Rel expression was blocked by PF, whereas the induction of other NF-kappaB family members was not significantly affected.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PF	PF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	members	member	NOUN	NNS	Number=Plur	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	significantly	significantly	ADV	RB	_	_	_	_	_
31	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9109
# text = However, induction of NF-AT, which has the same signaling requirements as c-Rel induction, was not inhibited by PF.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	PF	PF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9110
# text = Among genes that respond to these transcription factors, IL-2 mRNA induction was suppressed by PF, whereas IL-2R(alpha) chain mRNA induction was not affected.
1	Among	among	ADJ	JJ	Degree=Pos	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	PF	PF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	whereas	whereas	SCONJ	IN	_	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2R	2r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
28	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9111
# text = These observations implicated c-Rel as an IL-2 promoter factor, for which experimental support was obtained from transient transfection experiments.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
17	support	support	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
22	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
23	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9112
# text = In contrast with the observation in T cells, c-Rel induction was not blocked by PF in B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	PF	PF	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9113
# text = The greater selectivity of PF, compared with FK506, at both the molecular and cellular levels may prove advantageous in manipulating T cell responses in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
3	selectivity	selectivity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PF	PF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
20	advantageous	advantageous	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	manipulating	manipulat	VERB	VBG	VerbForm=Ger	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9114
# text = Document 0030011694 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011694	0030011694	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9115
# text = Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: involvement of the conserved lymphokine element 0.
1	Calcineurin	Calcineurin	PROPN	NNP	Number=Sing	_	_	_	_
2	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	0	0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9116
# text = Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2) are produced by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in human T cell leukemia Jurkat cells.
1	Granulocyte	Granulocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-macrophage	-macrophage	NOUN	NN	Number=Sing	_	_	_	_
3	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
31	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
37	ionophore	ionophore	ADV	RB	_	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	A23187	A23187	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	T	T	PROPN	NNP	Number=Sing	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
45	leukemia	leukemia	ADP	IN	_	_	_	_	_
46	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9117
# text = The expression of GM-CSF and IL-2 is inhibited by immunosuppressive drugs such as cyclosporin A (CsA) and FK506.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
15	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
19	A	a	PROPN	NNP	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9118
# text = Earlier studies on the IL-2 gene expression showed that overexpression of calcineurin (CN), a Ca2+/calmodulin-dependent protein phosphatase, can stimulate transcription from the IL-2 promoter through the NF-AT-binding site.
1	Earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CN	CN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	Ca2+/calmodulin-dependent	Ca2+/calmodulin-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	through	through	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	AT	AT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9119
# text = In this study, we obtained evidence that transfection of the cDNAs for CN A (catalytic) and CN B (regulatory) subunits also augments transcription from the GM-CSF promoter and recovers the transcription inhibited by CsA.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	evidence	evidence	ADV	RB	NumType=Mult	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cDNAs	cDNAs	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	CN	CN	PROPN	NNP	Number=Sing	_	_	_	_
15	A	a	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	CN	CN	PROPN	NNP	Number=Sing	_	_	_	_
21	B	B	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
26	also	also	ADV	RB	_	_	_	_	_
27	augments	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	recovers	recover	VERB	VB	VerbForm=Inf	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9120
# text = The constitutively active type of the CN A subunit, which lacks the auto-inhibitory and calmodulin-binding domains, acts in synergy with PMA to activate transcription from the GM-CSF promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	constitutively	constitutively	ADJ	JJ	Degree=Pos	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CN	CN	NOUN	NN	Number=Sing	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	auto	auto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	calmodulin	calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9121
# text = We also found that the active CN partially replaces calcium ionophore in synergy with PMA to induce expression of endogenous GM-CSF and IL-2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	CN	CN	PROPN	NNP	Number=Sing	_	_	_	_
8	partially	partially	ADV	RB	_	_	_	_	_
9	replaces	replace	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
11	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
21	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9122
# text = By multimerizing the regulatory elements of the GM-CSF promoter, we found that one of the target sites for the CN action is the conserved lymphokine element 0 (CLE0), located at positions between -54 and -40.
1	By	by	SCONJ	IN	_	_	_	_	_
2	multimerizing	multimerize	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	target	target	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CN	Cn	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	action	action	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	_
30	0	0	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
38	between	between	ADP	IN	_	_	_	_	_
39	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
40	54	54	NUM	CD	NumType=Card	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9123
# text = Mobility shift assays showed that the CLE0 sequence has an AP1-binding site and is associated with an NF-AT-like factor, termed NF-CLE0 gamma.
1	Mobility	Mobility	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	AT	at	ADV	RB	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	_
31	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9124
# text = NF-CLE0 gamma binding is induced by PMA/A23187 and is inhibited by treatment with CsA.
1	NF	NF	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	A23187	A23187	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9125
# text = These results suggest that CN is involved in the coordinated induction of the GM-CSF and IL-2 genes and that the CLE0 sequence of the GM-CSF gene is a functional analogue of the NF-AT-binding site in the IL-2 promoter, which mediates signals downstream of T cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CN	CN	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
36	analogue	analogue	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	site	site	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	2	2	NUM	CD	NumType=Card	_	_	_	_
50	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	which	which	PRON	WDT	PronType=Rel	_	_	_	_
53	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
54	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
55	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	T	t	NUM	CD	NumType=Card	_	_	_	_
58	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
59	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9126
# text = Document 0030011702 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011702	0030011702	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9127
# text = Distinct signaling properties identify functionally different CD4 epitopes.
1	Distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
4	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	functionally	functionally	ADV	RB	_	_	_	_	_
6	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
7	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
8	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9128
# text = The CD4 coreceptor interacts with non-polymorphic regions of major histocompatibility complex class II molecules on antigen-presenting cells and contributes to T cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	_
3	coreceptor	coreceptor	NOUN	NN	Number=Sing	_	_	_	_
4	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	non-polymorphic	non-polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
7	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	presenting	presenting	VERB	VBG	VerbForm=Ger	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9129
# text = We have investigated the effect of CD4 triggering on T cell activating signals in a lymphoma model using monoclonal antibodies (mAb) which recognize different CD4 epitopes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
8	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
17	model	model	NOUN	NN	Number=Sing	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
20	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	_
28	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9130
# text = We demonstrate that CD4 triggering delivers signals capable of activating the NF-AT transcription factor which is required for interleukin-2 gene expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
6	delivers	deliver	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9131
# text = Whereas different anti-CD4 mAb or HIV-1 gp120 could all trigger activation of the protein tyrosine kinases p56lck and p59fyn and phosphorylation of the Shc adaptor protein, which mediates signals to Ras, they differed significantly in their ability to activate NF-AT.
1	Whereas	whereas	ADV	RB	_	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	anti-CD4	anti-CD4	ADP	IN	Abbr=Yes	_	_	_	_
4	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gp120	gp120	NOUN	NN	Number=Sing	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	trigger	trigger	ADJ	JJR	Degree=Cmp	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
18	kinases	kinase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	p56lck	p56lck	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	p59fyn	p59fyn	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Shc	Shc	PROPN	NNP	Number=Sing	_	_	_	_
27	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
37	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	significantly	significantly	ADV	RB	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
41	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
44	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9132
# text = Lack of full activation of NF-AT could be correlated to a dramatically reduced capacity to induce calcium flux and could be complemented with a calcium ionophore.
1	Lack	lack	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	AT	AT	PRON	WDT	PronType=Rel	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	dramatically	dramatically	ADV	RB	_	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	flux	flux	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	complemented	complement	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
28	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9133
# text = The results identify functionally distinct epitopes on the CD4 coreceptor involved in activation of the Ras/protein kinase C and calcium pathways.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	functionally	functionally	ADV	RB	_	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	_
10	coreceptor	coreceptor	NOUN	NN	Number=Sing	_	_	_	_
11	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Ras	Ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	C	c	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
23	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9134
# text = Document 0030011707 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011707	0030011707	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9135
# text = Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	interferon	interferon	ADP	IN	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9136
# text = We have examined the feasibility of using interferon (IFN) gene transfer as a novel approach to anti-human immunodeficiency virus type 1 (HIV-1) therapy in this study.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	feasibility	feasibility	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
17	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9137
# text = To limit expression of a transduced HIV-1 long terminal repeat (LTR)-IFNA2 (the new approved nomenclature for IFN genes is used throughout this article) hybrid gene to the HIV-1-infected cells, HIV-1 LTR was modified.
1	To	to	PART	TO	_	_	_	_	_
2	limit	limit	VERB	VB	VerbForm=Inf	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	IFNA2	Ifna2	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
21	approved	approve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	nomenclature	nomenclature	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	throughout	throughout	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	article	article	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
47	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
48	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9138
# text = Deletion of the NF-kappa B elements of the HIV-1 LTR significantly inhibited Tat-mediated transactivation in T-cell lines, as well as in a monocyte line, U937.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	as	as	ADV	RB	_	_	_	_	_
27	well	well	ADV	RB	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
32	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9139
# text = Replacement of the NF-kappa B elements in the HIV-1 LTR by a DNA fragment derived from the 5'-flanking region of IFN-stimulated gene 15 (ISG15), containing the IFN-stimulated response element, partially restored Tat-mediated activation of LTR in T cells as well as in monocytes.
1	Replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	15	15	NUM	CD	NumType=Card	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	ISG15	ISG15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	response	response	NOUN	NN	Number=Sing	_	_	_	_
43	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	partially	partially	ADV	RB	_	_	_	_	_
46	restored	restore	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
56	as	as	ADV	RB	_	_	_	_	_
57	well	well	ADV	RB	Degree=Pos	_	_	_	_
58	as	as	ADP	IN	_	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9140
# text = Insertion of this chimeric promoter (ISG15 LTR) upstream of the human IFNA2 gene directed high levels of IFN synthesis in Tat-expressing cells, while this promoter was not responsive to tumor necrosis factor alpha-mediated activation.
1	Insertion	Insertion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	chimeric	chimeric	NOUN	NN	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ISG15	ISG15	NUM	CD	NumType=Card	_	_	_	_
8	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	IFNA2	Ifna2	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	PRON	NN	Number=Sing	_	_	_	_
16	directed	direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	while	while	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
36	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9141
# text = ISG15-LTR-IFN hybrid gene inserted into the retrovirus vector was transduced into Jurkat and U937 cells.
1	ISG15	ISG15	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
6	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	inserted	insert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	_
12	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	U937	U937	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9142
# text = Selected transfected clones produced low levels of IFN A (IFNA) constitutively, and their abilities to express interleukin-2 and interleukin-2 receptor upon stimulation with phytohemagglutinin and phorbol myristate acetate were retained.
1	Selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
9	A	a	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IFNA	IFNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	constitutively	constitutively	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	abilities	ability	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	upon	upon	ADP	IN	_	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
34	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
35	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9143
# text = Enhancement of IFNA synthesis observed upon HIV-1 infection resulted in significant inhibition of HIV-1 replication for a period of at least 30 days.
1	Enhancement	Enhancement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IFNA	IFNA	PROPN	NNP	Number=Sing	_	_	_	_
4	synthesis	synthesis	PROPN	NNP	Number=Sing	_	_	_	_
5	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	upon	upon	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
11	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	period	period	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	at	at	ADV	RB	_	_	_	_	_
25	least	least	ADV	RBS	Degree=Sup	_	_	_	_
26	30	30	NUM	CD	NumType=Card	_	_	_	_
27	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9144
# text = Virus isolated from IFNA-producing cells was able to replicate in the U937 cells but did not replicate efficiently in U937 cells transduced with the IFNA gene.
1	Virus	virus	PROPN	NNP	Number=Sing	_	_	_	_
2	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	IFNA	IFNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
20	efficiently	efficiently	ADV	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	U937	U937	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IFNA	IFNA	PROPN	NNP	Number=Sing	_	_	_	_
28	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9145
# text = These results suggest that targeting IFN synthesis to HIV-1-infected cells is an attainable goal and that autocrine IFN synthesis results in a long-lasting and permanent suppression of HIV-1 replication.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	targeting	targete	VERB	VBG	VerbForm=Ger	_	_	_	_
6	IFN	Ifn	ADP	RP	_	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-infected	-infect	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	attainable	attainable	ADJ	JJ	Degree=Pos	_	_	_	_
17	goal	goal	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
21	IFN	Ifn	ADP	IN	_	_	_	_	_
22	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
23	results	result	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	lasting	lasting	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
31	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9146
# text = Document 0030011711 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011711	0030011711	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9147
# text = Expression levels of the thyrotropin receptor gene in autoimmune thyroid disease: coregulation with parameters of thyroid function and inverse relation to major histocompatibility complex classes I and II.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	thyrotropin	thyrotropin	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
10	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
11	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	coregulation	coregulation	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	inverse	inverse	NOUN	NN	Number=Sing	_	_	_	_
21	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
24	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9148
# text = Using a human TSH receptor (TSH-R) cDNA probe, we investigated TSH-R transcript levels in 13 human thyroid fragments by Northern blot analysis; 7 Graves' disease, 2 Hashimoto's disease, 3 endemic goiter, and 1 healthy thyroid gland were studied.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	TSH	TSh	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TSH	TSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
12	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	TSH	TSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	R	R	PROPN	NNP	Number=Sing	_	_	_	_
19	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	13	13	NUM	CD	NumType=Card	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
25	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
28	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
29	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	;	;	PUNCT	,	_	_	_	_	_
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	Graves	Grave	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	'	's	PART	POS	_	_	_	_	_
34	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	Hashimoto	Hashimoto	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	's	's	PART	POS	_	_	_	_	_
39	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	3	3	NUM	CD	NumType=Card	_	_	_	_
42	endemic	endemic	ADJ	JJ	Degree=Pos	_	_	_	_
43	goiter	goiter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
48	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
49	gland	gland	NOUN	NN	Number=Sing	_	_	_	_
50	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9149
# text = TSH-R expression levels were variable, but displayed a close correlation to the expression of thyroid peroxidase (r = 0.703; P < 0.05), thyroglobulin (r = 0.817; P < 0.01), and the nuclear oncogene c-fos (r = 0.935; P < 0.001), but not c-myc.
1	TSH	Tsh	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	R	r	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
13	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
19	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	r	r	NOUN	NN	Number=Sing	_	_	_	_
22	=	=	SYM	SYM	_	_	_	_	_
23	0.703	0.703	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	;	;	PUNCT	,	_	_	_	_	_
25	P	P	NOUN	NN	Number=Sing	_	_	_	_
26	<	<	PUNCT	-LRB-	_	_	_	_	_
27	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	thyroglobulin	thyroglobulin	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	r	r	NOUN	NN	Number=Sing	_	_	_	_
33	=	=	SYM	SYM	_	_	_	_	_
34	0.817	0.817	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	P	P	NOUN	NN	Number=Sing	_	_	_	_
37	<	<	PUNCT	-LRB-	_	_	_	_	_
38	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
45	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	r	r	NOUN	NN	Number=Sing	_	_	_	_
49	=	=	SYM	SYM	_	_	_	_	_
50	0.935	0.935	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	;	;	PUNCT	,	_	_	_	_	_
52	P	p	NOUN	NN	Number=Sing	_	_	_	_
53	<	<	PUNCT	-LRB-	_	_	_	_	_
54	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	but	but	CCONJ	CC	_	_	_	_	_
58	not	not	ADV	RB	_	_	_	_	_
59	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
60	myc.	myc.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9150
# text = Overall, TSH-R transcript levels were low or absent in those thyroids in which expression of the major histocompatibility complex class I or II (MHC I or II) was high, thus establishing an inverse relation (MHC I, r = -0.791; P < 0.01; MHC II, r = -0.784; P < 0.01).
1	Overall	overall	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TSH	TSH	X	GW	_	_	_	_	SpaceAfter=No
4	-	-	X	GW	_	_	_	_	SpaceAfter=No
5	R	be	X	GW	_	_	_	_	_
6	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	thyroids	thyroid	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	II	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	thus	thus	ADV	RB	_	_	_	_	_
37	establishing	establish	VERB	VBG	VerbForm=Ger	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	inverse	inverse	ADJ	JJ	Degree=Pos	_	_	_	_
40	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	r	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	=	=	SYM	SYM	_	_	_	_	_
47	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
48	0.791	0.791	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	;	;	PUNCT	,	_	_	_	_	_
50	P	P	NOUN	NN	Number=Sing	_	_	_	_
51	<	<	PUNCT	-LRB-	_	_	_	_	_
52	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	;	;	PUNCT	,	_	_	_	_	_
54	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
55	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	r	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
58	=	=	SYM	SYM	_	_	_	_	_
59	-0.784	-0.784	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	;	;	PUNCT	,	_	_	_	_	_
61	P	P	NOUN	NN	Number=Sing	_	_	_	_
62	<	<	PUNCT	-LRB-	_	_	_	_	_
63	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9151
# text = In situ hybridization showed that apart from lymphocytes, thyroid cells themselves were the source of MHC II transcripts.
1	In	in	ADP	IN	_	_	_	_	_
2	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
3	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	apart	apart	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	themselves	themselves	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
13	were	be	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	source	source	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MHC	MHC	PROPN	NNPS	Number=Plur	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9152
# text = gamma-Interferon expression was only detectable in 1 Hashimoto's goiter.
1	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	Hashimoto	Hashimoto	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	's	's	PART	POS	_	_	_	_	_
12	goiter	goiter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9153
# text = Our findings suggest that next to lymphocyte infiltration, active regulatory events in the thyrocyte are responsible for the inverse relation between functional parameters (TSH-R, thyroid peroxidase, thyroglobulin, and c-fos) and immunological markers (MHC I and II).
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	next	next	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	lymphocyte	lymphocyte	VERB	VB	VerbForm=Inf	_	_	_	_
8	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	events	event	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	thyrocyte	thyrocyte	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inverse	inverse	ADJ	JJ	Degree=Pos	_	_	_	_
21	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
24	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TSH	TSh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	R	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
31	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	thyroglobulin	thyroglobulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
41	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
44	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9154
# text = Document 0030011714 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011714	0030011714	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9155
# text = An in vitro globin gene switching model based on differentiated embryonic stem cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
4	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
7	model	model	NOUN	NN	Number=Sing	_	_	_	_
8	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
12	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9156
# text = We used mouse embryonic stem (ES) cells to study globin gene expression and switching in vitro.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
5	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ES	ES	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
12	globin	globin	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	switching	switch	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9157
# text = We show that ES-derived embryoid bodies express the full complement of mouse embryonic globin genes in the correct temporal order and that on further differentiation, a switch occurs to the fetal/adult genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	ES	ES	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	embryoid	embryoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	bodies	body	NOUN	NNS	Number=Plur	_	_	_	_
9	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
12	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
15	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	correct	correct	ADJ	JJ	Degree=Pos	_	_	_	_
21	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
22	order	order	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
31	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
37	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9158
# text = In addition, the erythroid-specific transcription factor NF-E1 was shown to be expressed coordinately with that of globin in embryoid bodies.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	coordinately	coordinately	ADV	RB	_	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	embryoid	embryoid	ADJ	JJ	Degree=Pos	_	_	_	_
25	bodies	body	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9159
# text = We conclude from these experiments that the ES cell system provides a good model to study hematopoietic development.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	ES	ES	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	system	system	NOUN	NN	Number=Sing	_	_	_	_
11	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	good	good	ADJ	JJ	Degree=Pos	_	_	_	_
14	model	model	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
17	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9160
# text = When the human epsilon- or beta-globin genes driven by the dominant control region (DCR) are introduced into this system, the human epsilon-globin gene, in contrast to the beta-globin gene, is not deregulated by the presence of the DCR and is expressed strictly as an embryonic gene.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	DCR	Dcr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	into	into	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	not	not	PART	RB	_	_	_	_	_
44	deregulated	deregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	DCR	DCR	PROPN	NNP	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
54	strictly	strictly	ADV	RB	_	_	_	_	_
55	as	as	ADP	IN	_	_	_	_	_
56	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
57	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
58	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9161
# text = We conclude from this that the epsilon-globin gene is not regulated by competition with other genes in the human beta-globin locus.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
25	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9162
# text = Document 0030011715 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011715	0030011715	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9163
# text = Expression of LAZ3/BCL6 in follicular center (FC) B cells of reactive lymph nodes and FC-derived non-Hodgkin lymphomas.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LAZ3/BCL6	LAZ3/BCL6	NUM	CD	NumType=Card	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
6	center	center	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	FC	FC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
15	nodes	node	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	FC	FC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	non-Hodgkin	non-hodgkin	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9164
# text = Chromosomal translocation resulting in abnormal expression of the LAZ3/BCL6 gene in B cells has been implicated in the tumorigenesis of non-Hodgkin lymphoma (NHL).
1	Chromosomal	Chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	LAZ	LAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	BCL6	BCL6	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tumorigenesis	tumorigenesis	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	non-Hodgkin	non-hodgkin	ADJ	JJ	Degree=Pos	_	_	_	_
25	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	NHL	NHL	INTJ	UH	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9165
# text = Therefore we studied the expression pattern of LAZ3/BCL6 by in situ hybridization with synthetic oligonucleotide probes in frozen tissue sections from five reactive lymph nodes and 38 B cell and non-B NHL.
1	Therefore	therefore	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	LAZ	LAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	BCL6	BCL6	NUM	CD	NumType=Card	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
15	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
18	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
19	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	frozen	frozen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
23	sections	section	NOUN	NNS	Number=Plur	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	five	five	NUM	CD	NumType=Card	_	_	_	_
26	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
27	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
28	nodes	node	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	38	38	NUM	CD	NumType=Card	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	non	non	X	AFX	_	_	_	_	SpaceAfter=No
35	-B	-b	PROPN	NNP	Number=Sing	_	_	_	_
36	NHL	Nhl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9166
# text = In addition, we investigated the expression of LAZ3/BCL6 by Northern blot analysis on multiple human tissues.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	LAZ	LAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	BCL6	BCL6	NUM	CD	NumType=Card	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
15	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
16	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9167
# text = The LAZ3/BCL6 transcript was found in a variety of tissues, including skeletal muscle, peripheral blood leukocytes, and weakly in normal lymph nodes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	LAZ	LAZ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	BCL6	BCL6	NUM	CD	NumType=Card	_	_	_	_
6	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	skeletal	skeletal	ADJ	JJ	Degree=Pos	_	_	_	_
17	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	weakly	weakly	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
28	nodes	node	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9168
# text = In the tumor samples, expression of LAZ3/BCL6 was observed in 68% of all B cell NHL and none of the non-B lymphomas.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	LAZ	LAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	BCL6	Bcl6	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	68	68	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	all	all	DET	DT	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	NHL	Nhl	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	none	none	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	non	non	X	AFX	_	_	_	_	SpaceAfter=No
27	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
28	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9169
# text = All cases of follicular, mixed small and large cell lymphomas showed LAZ3/BCL6 expression confined to the neoplastic follicles.
1	All	all	DET	DT	_	_	_	_	_
2	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	mixed	mixed	ADJ	JJ	Degree=Pos	_	_	_	_
7	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	LAZ	LAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	BCL6	BCL6	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	confined	confine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
22	follicles	follicle	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9170
# text = A follicular expression pattern was also found in all non-malignant reactive lymph nodes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	non-malignant	non-malignant	ADJ	JJ	Degree=Pos	_	_	_	_
11	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
13	nodes	node	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9171
# text = Hence, the expression of LAZ3/BCL6 does not correlate to malignancy, but reflects the origin of B cells from the germinal centers.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	LAZ	LAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	BCL6	BCL6	NOUN	NN	Number=Sing	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	malignancy	malignancy	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
26	centers	center	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9172
# text = Document 0030011725 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011725	0030011725	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9173
# text = Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
5	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9174
# text = The molecular mechanisms regulating human immunodeficiency virus (HIV) persistence in a major cell reservoir such as the macrophage remain unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9175
# text = NF-kappa B is a transcription factor involved in the regulation of the HIV long terminal repeat and is selectively activated following HIV infection of human macrophages.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	selectively	selectively	ADV	RB	_	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
24	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9176
# text = Although little information as to what signal transduction pathways mediate NF-kappa B activation in monocytes-macrophages is available, our previous work indicated that classical protein kinase C (PKC) isoenzymes were not involved in the HIV-mediated NF-kappa B activation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
3	information	information	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	SCONJ	IN	_	_	_	_	_
5	to	to	SCONJ	IN	_	_	_	_	_
6	what	what	PRON	WP	PronType=Int	_	_	_	_
7	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	available	available	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
24	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
25	work	work	NOUN	NN	Number=Sing	_	_	_	_
26	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	C	C	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	isoenzymes	isoenzyme	NOUN	NNS	Number=Plur	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	HIV-	Hiv-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
46	B	b	NOUN	NN	Number=Sing	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9177
# text = In this study, we have focused on atypical PKC isoenzymes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	atypical	atypical	ADJ	JJ	Degree=Pos	_	_	_	_
10	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
11	isoenzymes	isoenzyme	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9178
# text = PKC-zeta belongs to this family and is known to be an important step in NF-kappa B activation in other cell systems.
1	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
4	belongs	belong	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	step	step	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9179
# text = Immunoblotting experiments with U937 cells demonstrate that PKC-zeta is present in these cells, and its expression can be downmodulated by antisense oligonucleotides (AO).
1	Immunoblotting	Immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	downmodulated	downmodulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
25	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	AO	AO	INTJ	UH	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9180
# text = The HIV-mediated NF-kappa B activation is selectively reduced by AO to PKC-zeta.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV-	Hiv-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	AO	AO	PROPN	NNP	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	zeta	zeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9181
# text = In addition, cotransfection of a negative dominant molecule of PKC-zeta (PKC-zeta mut) with NF-kappa B-dependent reporter genes selectively inhibits the HIV- but not phorbol myristate acetate- or lipopolysaccharide-mediated activation of NF-kappa B.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
18	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
29	selectively	selectively	ADV	RB	_	_	_	_	_
30	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	ADV	RB	_	_	_	_	_
36	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
37	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
38	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
49	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9182
# text = That PKC-zeta is specific in regulating NF-kappa B is concluded from the inability of PKC-zeta(mut) to interfere with the basal or phorbol myristate acetate-inducible CREB- or AP1-dependent transcriptional activity.
1	That	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	SCONJ	IN	_	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	PKC-zeta	PKC-zeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
30	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
31	acetate	acetate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
32	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
33	CREB	Creb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9183
# text = Lastly, we demonstrate a selective inhibition of p24 production by HIV-infected human macrophages when treated with AO to PKC-zeta.
1	Lastly	Lastly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	p24	p24	NUM	CD	NumType=Card	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	HIV-	HIV-	X	GW	_	_	_	_	SpaceAfter=No
13	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	AO	AO	PROPN	NNP	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	zeta	zeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9184
# text = Altogether, these results suggest that atypical PKC isoenzymes, including PKC-zeta, participate in the signal transduction pathways by which HIV infection results in the activation of NF-kappa B in human monocytic cells and macrophages.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	atypical	atypical	ADJ	JJ	Degree=Pos	_	_	_	_
8	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
9	isoenzymes	isoenzyme	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
20	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
21	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	HIV	Hiv	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	results	result	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9185
# text = Document 0030011727 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011727	0030011727	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9186
# text = Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
5	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
13	persistently	persistently	ADV	RB	_	_	_	_	_
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9187
# text = The mechanisms regulating human immunodeficiency virus (HIV) persistence in human monocytes/macrophages are partially understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	partially	partially	ADV	RB	_	_	_	_	_
18	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9188
# text = Persistent HIV infection of U937 monocytic cells results in NF-kappa B activation.
1	Persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
3	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	U937	U937	NUM	CD	NumType=Card	_	_	_	_
6	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9189
# text = Whether virus-induced NF-kappa B activation is a mechanism that favors continuous viral replication in macrophages remains unknown.
1	Whether	whether	SCONJ	IN	_	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	favors	favor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
20	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9190
# text = To further delineate the molecular mechanisms involved in the activation of NF-kappa B in HIV-infected monocytes and macrophages, we have focused on the regulation of the I kappa B molecules.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
33	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
34	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9191
# text = First, we show that persistent HIV infection results in the activation of NF-kappa
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 9192
# text = B not only in monocytic cells but also in macrophages.
1	B	b	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	not	not	ADV	RB	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9193
# text = In HIV-infected cells, I kappa B alpha protein levels are decreased secondary to enhanced protein degradation.
1	In	in	ADP	IN	_	_	_	_	_
2	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9194
# text = This parallels the increased I kappa B alpha synthesis secondary to increased I kappa B alpha gene transcription, i.e., increased RNA and transcriptional activity of its promoter-enhancer.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	parallels	parallel	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	ADV	RB	_	_	_	_	_
9	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9195
# text = Another protein with I kappa B function, p105, is also modified in HIV-infected cells: p105 and p50 steady-state protein levels are increased as a result of increased synthesis and proteolytic processing of p105.
1	Another	another	DET	DT	_	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	p105	p105	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	p50	p50	NUM	CD	NumType=Card	_	_	_	_
22	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	state	state	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	result	result	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9196
# text = Transcriptional activity of p105 is also increased in infected cells and is also mediated by NF-kappa B through a specific kappa B motif.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9197
# text = These results demonstrate the existence of a triple autoregulatory loop in monocytes and macrophages involving HIV, p105 and p50, and MAD3, with the end result of persistent NF-kappa B activation and viral persistence.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	triple	triple	ADJ	JJ	Degree=Pos	_	_	_	_
9	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
15	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	p105	p105	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	MAD3	MAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	end	end	NOUN	NN	Number=Sing	_	_	_	_
28	result	result	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
38	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9198
# text = Furthermore, persistent HIV infection of monocytes and macrophages provides a useful model with which to study concomitant modifications of different I kappa B molecules.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
4	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
10	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
13	model	model	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
18	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
19	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
23	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9199
# text = Document 0030011731 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011731	0030011731	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9200
# text = Characterization of 5' end of human thromboxane receptor gene.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	``	_	_	_	_	_
5	end	end	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9201
# text = Organizational analysis and mapping of protein kinase C--responsive elements regulating expression in platelets.
1	Organizational	organizational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
10	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9202
# text = Platelet thromboxane receptors are acutely and reversibly upregulated after acute myocardial infarction.
1	Platelet	Platelet	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	thromboxane	thromboxane	PRON	PRP	_	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	acutely	acutely	ADV	RB	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	reversibly	reversibly	ADV	RB	_	_	_	_	_
8	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
12	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9203
# text = To determine if platelet thromboxane receptors are under transcriptional control, we isolated and characterized human genomic DNA clones containing the 5' flanking region of the thromboxane receptor gene.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	if	if	SCONJ	IN	_	_	_	_	_
4	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
5	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	under	under	ADP	IN	_	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	'	'	PUNCT	``	_	_	_	_	_
24	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9204
# text = The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	exon	exon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
5	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	's	PUNCT	``	_	_	_	_	_
10	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	thromboxane	thromboxane	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	initially	initially	ADV	RB	_	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	comparing	compare	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	'	'	PUNCT	``	_	_	_	_	_
28	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
29	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
30	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	uterine	uterine	NOUN	NN	Number=Sing	_	_	_	_
38	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
39	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
40	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
41	that	that	PRON	WDT	PronType=Rel	_	_	_	_
42	extended	extend	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
45	141	141	NUM	CD	NumType=Card	_	_	_	_
46	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
47	further	further	ADV	RBR	Degree=Cmp	_	_	_	_
48	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
49	than	than	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	previously	previously	ADV	RB	_	_	_	_	_
52	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
54	placental	placental	NOUN	NN	Number=Sing	_	_	_	_
55	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9205
# text = A major transcription initiation site was located in three human tissues approximately 560 bp upstream from the translation initiation codon and 380 bp upstream from any previously identified transcription initiation site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	560	560	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
19	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
20	codon	codon	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	380	380	NUM	CD	NumType=Card	_	_	_	_
23	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
24	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	any	any	DET	DT	_	_	_	_	_
27	previously	previously	ADV	RB	_	_	_	_	_
28	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9206
# text = The thromboxane receptor gene has neither a TATA nor a CAAT consensus site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	neither	neither	CCONJ	CC	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
9	nor	nor	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	CAAT	Caat	NOUN	NN	Number=Sing	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9207
# text = Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/chloramphenicol acetyltransferase (CAT) chimera plasmids into platelet-like K562 cells.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	'	PUNCT	``	_	_	_	_	_
7	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thromboxane	thromboxane	PRON	PRP	_	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
25	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	chimera	chimera	NOUN	NN	Number=Sing	_	_	_	_
30	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
31	into	into	ADP	IN	_	_	_	_	_
32	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	like	like	INTJ	UH	_	_	_	_	_
35	K562	K562	NUM	CD	NumType=Card	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9208
# text = Thromboxane receptor promoter activity, as assessed by CAT expression, was relatively weak but was significantly enhanced by phorbol ester treatment.
1	Thromboxane	Thromboxane	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	as	as	SCONJ	IN	_	_	_	_	_
7	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	relatively	relatively	ADV	RB	_	_	_	_	_
14	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
21	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9209
# text = Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester-responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 (AP-2) binding consensus sites located approximately 1.8 kb
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	'	'	PUNCT	``	_	_	_	_	_
6	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
7	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	K562	K562	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
14	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
15	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
16	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
45	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
46	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	approximately	approximately	ADV	RB	_	_	_	_	_
48	1.8	1.8	NUM	CD	NumType=Card	_	_	_	_
49	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9210
# text = 5' from the transcription initiation site.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9211
# text = These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2-like nuclear factor binding to upstream promoter elements.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	_
16	end	end	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	thromboxane	thromboxane	PRON	PRP	_	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
37	C	c	NOUN	NN	Number=Sing	_	_	_	_
38	via	via	ADP	IN	_	_	_	_	_
39	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	like	like	ADP	IN	_	_	_	_	_
47	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
48	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
49	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
53	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9212
# text = These findings strongly suggest that the mechanism for previously described upregulation of platelet thromboxane receptors after acute myocardial infarction is increased thromboxane receptor gene transcription in platelet-progenitor cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	previously	previously	ADV	RB	_	_	_	_	_
10	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
14	thromboxane	thromboxane	PRON	PRP	_	_	_	_	_
15	receptors	receptor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
18	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
19	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	thromboxane	thromboxane	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9213
# text = Document 0030011736 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011736	0030011736	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9214
# text = The effect of Toremifene on the expression of some genes in human mononuclear cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Toremifene	Toremifene	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	some	some	DET	DT	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9215
# text = Toremifene exerts multiple and varied effects on the gene expression of human peripheral mononuclear cells.
1	Toremifene	Toremifene	PRON	PRP	_	_	_	_	_
2	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	varied	varied	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9216
# text = After short-term, in vitro exposure to therapeutical levels, distinct changes in P-glycoprotein, steroid receptors, p53 and Bcl-2 expression take place.
1	After	after	ADP	IN	_	_	_	_	_
2	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	term	term	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
8	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	therapeutical	therapeutical	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
20	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	p53	p53	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	take	take	NOUN	NN	Number=Sing	_	_	_	_
29	place	place	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9217
# text = In view of the increasing use of antiestrogens in cancer therapy and prevention, there is obvious merit in long-term in vivo studies to be conducted.
1	In	in	ADP	IN	_	_	_	_	_
2	view	view	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
6	use	use	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	antiestrogens	antiestrogen	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
11	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	there	there	PRON	EX	_	_	_	_	_
16	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	obvious	obvious	ADJ	JJ	Degree=Pos	_	_	_	_
18	merit	merit	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	term	term	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
25	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9218
# text = Document 0030011738 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011738	0030011738	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9219
# text = Role of HIV-1 Nef expression in activation pathways in CD4+ T cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	Nef	Nef	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	T	t	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9220
# text = The role of the human immunodeficiency virus (HIV-1) Nef protein in T cell activation pathways was investigated using a Jurkat CD4+ cell line stably transfected with a Nef expression vector.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
25	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	stably	stably	ADV	RB	_	_	_	_	_
30	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9221
# text = Secretion of IL-2 and TNF-alpha, surface expression of IL-2R, and DNA-binding activity of NF-kappa B and AP-1 (Fos/Jun) complex in response to phorbol myristate acetate, TNF-alpha, or immobilized antibodies to CD3 were monitored.
1	Secretion	Secretion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2R	2R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
42	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
43	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	or	or	CCONJ	CC	_	_	_	_	_
50	immobilized	immobilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
52	to	to	ADP	IN	_	_	_	_	_
53	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
54	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9222
# text = These parameters were not modified by Nef expression in Jurkat cells, whereas stimulation with the same stimuli resulted in partial inhibition of LTR activation in Nef+ Jurkat cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
19	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	+	+	SYM	SYM	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9223
# text = This inhibition was not mediated through Nef phosphorylation on Thr-15 or GTP-binding activity because mutations in critical sites did not alter this inhibition.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	Thr	Thr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-15	-15	NUM	CD	NumType=Card	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	GTP	Gtp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	because	because	SCONJ	IN	_	_	_	_	_
18	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	alter	alter	ADV	RB	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9224
# text = Analysis of truncated LTRs confirmed that inhibition of LTR activation was not mediated through NF-kappa B-binding activity but through the region containing the negative responding elements (NREs).
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	LTRs	LTRs	NOUN	NNS	Number=Plur	_	_	_	_
5	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	responding	responding	NOUN	NN	Number=Sing	_	_	_	_
30	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	NREs	NREs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9225
# text = These results suggest that Nef downmodulates LTR activation without significantly inhibiting the capacity of T cells to respond to immunological activations.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
6	downmodulates	downmodulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	LTR	LTR	ADJ	JJR	Degree=Cmp	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	without	without	SCONJ	IN	_	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
21	activations	activation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9226
# text = Document 0030011740 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011740	0030011740	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9227
# text = Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2.
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	_
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
5	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9228
# text = Expression of the human immunodeficiency virus type 1 (HIV) protease in cultured cells leads to apoptosis, preceded by cleavage of bcl-2, a key negative regulator of cell death.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
30	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
31	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9229
# text = In contrast, a high level of bcl-2 protects cells in vitro and in vivo from the viral protease and prevents cell death following HIV infection of human lymphocytes, while reducing the yields of viral structural proteins, infectivity, and tumor necrosis factor alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	protects	protect	NOUN	NNS	Number=Plur	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
21	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
24	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	death	death	SCONJ	IN	_	_	_	_	_
26	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
27	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
28	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	while	while	SCONJ	IN	_	_	_	_	_
34	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	yields	yield	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
39	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	infectivity	infectivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
46	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
48	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9230
# text = We present a model for HIV replication in which the viral protease depletes the infected cells of bcl-2, leading to oxidative stress-dependent activation of NF kappa B, a cellular factor required for HIV transcription, and ultimately to cell death.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	present	present	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
7	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
13	depletes	deplete	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
25	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
37	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	ultimately	ultimately	ADV	RB	_	_	_	_	_
44	to	to	PART	TO	_	_	_	_	_
45	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
46	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9231
# text = Purified bcl-2 is cleaved by HIV protease between phenylalanine 112 and alanine 113.
1	Purified	Purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	cleaved	cleave	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
9	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	phenylalanine	phenylalanine	NUM	CD	NumType=Card	_	_	_	_
12	112	112	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	alanine	alanine	NUM	CD	NumType=Card	_	_	_	_
15	113	113	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9232
# text = The results suggest a new option for HIV gene therapy; bcl-2 muteins that have noncleavable alterations surrounding the HIV protease cleavage site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	option	option	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	muteins	mutein	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	noncleavable	noncleavable	ADJ	JJ	Degree=Pos	_	_	_	_
19	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
20	surrounding	surround	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
23	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
24	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9233
# text = Document 0030011742 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011742	0030011742	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9234
# text = Differentiation-dependent expression of a human carboxylesterase in monocytic cells and transcription factor binding to the promoter.
1	Differentiation	Differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	carboxylesterase	carboxylesterase	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9235
# text = Carboxylesterases play an important role in defense and clearance mechanisms of the monocyte/macrophage system.
1	Carboxylesterases	Carboxylesterase	NOUN	NNS	Number=Plur	_	_	_	_
2	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
16	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9236
# text = During the differentiation process of cells from the monocytic cell line THP-1 we observed a transient transcriptional upregulation of a human carboxylesterase analyzed by means of Northern blots.
1	During	during	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	process	process	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	carboxylesterase	carboxylesterase	NOUN	NN	Number=Sing	_	_	_	_
25	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	means	means	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
30	blots	blot	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9237
# text = In PMA-treated THP-1 cells we could detect three major transcription initiation sites as revealed by Nuclease Protection Assay carried out with two overlapping antisense RNA probes.
1	In	in	ADP	IN	_	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
12	three	three	NUM	CD	NumType=Card	_	_	_	_
13	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	Nuclease	Nuclease	PROPN	NNP	Number=Sing	_	_	_	_
21	Protection	protection	PROPN	NNP	Number=Sing	_	_	_	_
22	Assay	assay	PROPN	NNP	Number=Sing	_	_	_	_
23	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	out	out	ADV	RB	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	two	two	NUM	CD	NumType=Card	_	_	_	_
27	overlapping	overlapp	ADJ	JJ	Degree=Pos	_	_	_	_
28	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
29	RNA	RNa	ADP	IN	_	_	_	_	_
30	probes	probe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9238
# text = We have recently cloned the carboxylesterase upstream sequence and showed its basal promoter activity in CHO cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	carboxylesterase	carboxylesterase	NOUN	NN	Number=Sing	_	_	_	_
7	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	CHO	Cho	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9239
# text = Using electrophoretic mobility shift analysis we demonstrated that the promoter region spanning base pairs -1 to -275, which contains several putative binding sites for transcription factors, is bound by nuclear factors Sp1 and IRBP but not by C/EBPs.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	spanning	span	VERB	VBG	VerbForm=Ger	_	_	_	_
13	base	base	NOUN	NN	Number=Sing	_	_	_	_
14	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	275	275	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	putative	putative	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
36	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	IRBP	Irbp	NOUN	NN	Number=Sing	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	C/EBPs	C/EBPs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9240
# text = Taken together these data indicate that carboxylesterase gene transcription in THP-1 cells starts at multiple initiation sites and that Sp1 and IRBP may be critical factors for modulating the differentiation-dependent transcription of this human carboxylesterase gene.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	carboxylesterase	carboxylesterase	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	starts	start	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
18	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IRBP	Irbp	PROPN	NNP	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	SCONJ	IN	_	_	_	_	_
30	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	carboxylesterase	carboxylesterase	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9241
# text = Document 0030011747 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011747	0030011747	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9242
# text = Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line.
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
4	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
5	programs	program	NOUN	NNS	Number=Plur	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NKL	NKL	PROPN	NNP	Number=Sing	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9243
# text = NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis.
1	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	target	target	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9244
# text = Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	multiplex	multiplex	ADJ	JJ	Degree=Pos	_	_	_	_
8	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
9	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	here	here	ADV	RB	PronType=Dem	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
17	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	NKL	Nkl	NOUN	NN	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	very	very	ADV	RB	_	_	_	_	_
30	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
31	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
41	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	FosB	FosB	PROPN	NNP	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
48	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9245
# text = In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
12	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
17	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
18	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
19	assays	assays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	course	course	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9246
# text = Interaction between immunoglobulin-like transcript-2/leukocyte
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9247
# text = Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity.
1	Ig	ig	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	NKL	Nkl	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	B27	B27	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	target	target	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	impairment	impairment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NKL	NKL	PROPN	NNP	Number=Sing	_	_	_	_
22	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
23	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	FosB	FosB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	as	as	ADV	RB	_	_	_	_	_
42	well	well	ADV	RB	Degree=Pos	_	_	_	_
43	as	as	ADP	IN	_	_	_	_	_
44	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
48	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
51	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9248
# text = Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	despite	despite	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	rapidity	rapidity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
27	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
30	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	programs	program	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
40	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
43	class	class	NOUN	NN	Number=Sing	_	_	_	_
44	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
45	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
46	impairs	impairs	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	very	very	ADV	RB	_	_	_	_	_
49	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9249
# text = Document 0030011751 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011751	0030011751	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9250
# text = Octamer independent activation of transcription from the kappa immunoglobulin germline promoter.
1	Octamer	Octamer	PROPN	NNP	Number=Sing	_	_	_	_
2	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
10	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9251
# text = Previous analyses of immunoglobulin V region promoters has led to the discovery of a common octamer motif which is functionally important in the tissue-specific and developmentally regulated transcriptional activation of immunoglobulin genes.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
5	V	V	PROPN	NNP	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	discovery	discovery	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
16	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
17	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	functionally	functionally	ADV	RB	_	_	_	_	_
21	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	developmentally	developmentally	ADV	RB	_	_	_	_	_
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9252
# text = The germline promoters
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
3	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 9253
# text = (Ko) located upstream of the J region gene segments of the kappa locus also contain an octamer motif (containing a single base pair mutation and referred to as the variant octamer) which has been shown previously to bind Oct-1 and Oct-2 transcription factors in vitro.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ko	Ko	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	J	j	PROPN	NNP	Number=Sing	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	locus	locus	PROPN	NNP	Number=Sing	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
20	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
25	base	base	NOUN	NN	Number=Sing	_	_	_	_
26	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
27	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	variant	variant	ADJ	JJ	Degree=Pos	_	_	_	_
34	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	previously	previously	ADV	RB	_	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	bind	bind	ADP	IN	_	_	_	_	_
43	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	2	2	NUM	CD	NumType=Card	_	_	_	_
50	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
51	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9254
# text = To further elucidate the role of this variant octamer motif in the regulation of germline transcription from the unrearranged kappa locus, we have quantitated the relative binding affinity of Oct-1 and Oct-2 for the variant octamer motif and determined the functional role of this octamer motif in transcriptional activation.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
9	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	quantitated	quantitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	relative	relative	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	variant	variant	ADJ	JJ	Degree=Pos	_	_	_	_
41	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
42	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
47	role	role	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
50	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
51	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
54	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9255
# text = We find that, although the variant octamer motif binds Oct-1 and Oct-2 in vitro with 5-fold lower affinity than the consensus octamer motif, mutation of the variant octamer motif to either a consensus octamer or non-octamer motif has no effect on transcriptional activation from the germline promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	although	although	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	variant	variant	ADJ	JJ	Degree=Pos	_	_	_	_
8	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
23	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
24	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
28	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
29	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	variant	variant	ADJ	JJ	Degree=Pos	_	_	_	_
35	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
36	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	either	either	CCONJ	CC	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
41	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	non-octamer	non-octamer	NOUN	NN	Number=Sing	_	_	_	_
44	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
45	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	no	no	DET	DT	_	_	_	_	_
47	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
48	on	on	ADP	IN	_	_	_	_	_
49	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
51	from	from	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
54	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9256
# text = We also find significant differences in activation of germline and V region promoters by kappa enhancers.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	V	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9257
# text = Our results suggest that the germline promoters and V region promoters differ in their dependence on octamer for activation and respond differently to enhancer activation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
7	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	V	have	PROPN	NNP	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
12	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	differently	differently	ADV	RB	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9258
# text = These findings have important implications in regulation of germline transcription as well as concomitant activation of the V-J recombination of the kappa light chain locus.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	well	well	ADV	RB	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	V	V	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	J	j	PROPN	NNP	Number=Sing	_	_	_	_
21	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	light	light	NOUN	NN	Number=Sing	_	_	_	_
26	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
27	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9259
# text = Document 0030011752 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011752	0030011752	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9260
# text = Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes.
1	Recombinant	Recombinant	PROPN	NNP	Number=Sing	_	_	_	_
2	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9261
# text = Transcription factors of the NFAT family play a key role in the transcription of cytokine genes and other genes during the immune response.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9262
# text = We have identified two new isoforms of the transcription factor NFAT1 (previously termed NFATp) that are the predominant isoforms expressed in murine and human T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	previously	previously	ADV	RB	_	_	_	_	_
14	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
21	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9263
# text = When expressed in Jurkat T cells, recombinant NFAT1 is regulated, as expected, by the calmodulin-dependent phosphatase calcineurin, and its function is inhibited by the immunosuppressive agent cyclosporin A (CsA).
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
9	NFAT1	nfat1	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	calmodulin	calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
22	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
32	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
33	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
34	A	A	PROPN	NNP	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9264
# text = Transactivation by recombinant NFAT1 in Jurkat T cells requires dual stimulation with ionomycin and phorbol 12-myristate 13-acetate; this activity is potentiated by coexpression of constitutively active calcineurin and is inhibited by CsA.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
4	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	constitutively	constitutively	ADV	RB	_	_	_	_	_
31	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
32	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9265
# text = Immunocytochemical analysis indicates that recombinant NFAT1 localizes in the cytoplasm of transiently transfected T cells and translocates into the nucleus in a CsA-sensitive manner following ionomycin stimulation.
1	Immunocytochemical	Immunocytochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
6	NFAT1	nfat1	NOUN	NN	Number=Sing	_	_	_	_
7	localizes	localize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transiently	transiently	ADV	RB	_	_	_	_	_
13	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	translocates	translocate	NOUN	NNS	Number=Plur	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
26	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	ionomycin	ionomycin	ADP	IN	_	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9266
# text = When expressed in COS cells, however, NFAT1 is capable of transactivation, but it is not regulated correctly: its subcellular localization and transcriptional function are not affected by stimulation of the COS cells with ionomycin and phorbol 12-myristate 13-acetate.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	COS	Cos	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	correctly	correctly	ADV	RB	_	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
23	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	subcellular	subcellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	COS	COS	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
42	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
44	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
45	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
47	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9267
# text = Recombinant NFAT1 can mediate transcription of the interleukin-2, interleukin-4, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor promoters in T cells, suggesting that NFAT1 contributes to the CsA-sensitive transcription of these genes during the immune response.
1	Recombinant	Recombinant	NOUN	NN	Number=Sing	_	_	_	_
2	NFAT1	nfat1	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
17	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
25	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	_
37	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
46	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
47	during	during	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
50	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9268
# text = Document 0030011759 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011759	0030011759	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9269
# text = A novel immunosuppressive factor in bovine colostrum blocks activation of the interleukin 2 gene enhancer at the NFAT site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	bovine	bovine	ADJ	JJ	Degree=Pos	_	_	_	_
7	colostrum	colostrum	NOUN	NN	Number=Sing	_	_	_	_
8	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9270
# text = A factor in bovine colostrum (colostrum inhibitory factor, CIF) inhibits interleukin 2 (IL2) production in activated T helper cells by blocking the accumulation of IL2 mRNA.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
5	colostrum	colostrum	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	colostrum	colostrum	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CIF	CIF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL2	IL2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	by	by	SCONJ	IN	_	_	_	_	_
26	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	IL2	IL2	NUM	CD	NumType=Card	_	_	_	_
31	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9271
# text = To determine whether CIF blocks at the level of IL2 transcription, we introduced reporter plasmids into the human T leukemia cell line Jurkat by transient transfection.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	CIF	Cif	NOUN	NN	Number=Sing	_	_	_	_
5	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL2	IL2	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	introduced	introduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
27	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9272
# text = These contained the luciferase gene under the control of either the human IL2 upstream enhancer region (segments -326 to +45) or three repeats of the NFAT element contained within it (segments -255 to -285).
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	under	under	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	IL2	Il2	NOUN	NN	Number=Sing	_	_	_	_
14	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
19	-326	-326	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	+45	+45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	three	three	NUM	CD	NumType=Card	_	_	_	_
25	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	_
30	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	within	within	ADP	IN	_	_	_	_	_
32	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	255	255	NUM	CD	NumType=Card	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	285	285	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9273
# text = Expression of luciferase in these cells was induced by phorbol myristate acetate plus a calcium ionophore.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
12	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
13	plus	plus	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
16	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9274
# text = CIF inhibited induction of either construct as did cyclosporine, which is known to block activation of the NFAT element.
1	CIF	CIF	AUX	VB	VerbForm=Inf	_	_	_	_
2	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	either	either	DET	DT	_	_	_	_	_
6	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	SCONJ	IN	_	_	_	_	_
8	did	do	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9275
# text = CIF failed to inhibit several other enhancer elements.
1	CIF	CIF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9276
# text = The NFAT-controlled luciferase gene system distinguishes CIF from other T cell inhibitory activities present in colostrum, in particular, TGF beta 1 and TGF beta 2 and the glucocorticoids.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	system	system	NOUN	NN	Number=Sing	_	_	_	_
8	distinguishes	distinguish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	CIF	CIF	PROPN	NNP	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
14	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
15	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
16	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	colostrum	colostrum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9277
# text = Stably transfected Jurkat cells behaved similarly to the transiently transfected ones with respect to inhibition by CIF and cyclosporine.
1	Stably	Stably	ADV	RB	_	_	_	_	_
2	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	behaved	behave	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	similarly	similarly	ADV	RB	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transiently	transiently	ADV	RB	Degree=Pos	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	ones	one	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	inhibition	inhibition	VERB	VB	VerbForm=Inf	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	CIF	CIF	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9278
# text = The NFAT-luc assay is a useful technique for the rapid, sensitive measurement of CIF or other immunosuppressants with a similar mode of action.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	luc	luc	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
9	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
15	measurement	measurement	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CIF	CIF	PROPN	NNP	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
24	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9279
# text = Document 0030011762 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011762	0030011762	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9280
# text = Phenylarsine oxide inhibits ex vivo HIV-1 expression.
1	Phenylarsine	Phenylarsine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	oxide	oxide	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	ex	ex	SYM	SYM	_	_	_	_	_
5	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9281
# text = Phenylarsine oxide (PAO), which is described as an inhibitor of tyrosine phosphatase activity, inhibits
1	Phenylarsine	Phenylarsine	NOUN	NN	Number=Sing	_	_	_	_
2	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 9282
# text = H2O2 release from human peripheral blood mononuclear cells (PBMCs) as measured by electrochemistry.
1	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
2	release	release	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	electrochemistry	electrochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9283
# text = Since human immunodeficiency virus type 1 (HIV-1) replication is known to be favored under oxidative stress conditions, ex vivo experiments using uninfected PBMCs, primary monocytes or a latently infected promonocytic U1 cell line show that HIV-1 replication and reactivation, monitored by p24 antigen measurement, are inhibited by PAO in a time- and concentration-dependent manner.
1	Since	since	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	favored	favore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	under	under	ADP	IN	_	_	_	_	_
19	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
20	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
21	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	ex	ex	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
24	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
25	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
26	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
27	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
28	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
31	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	latently	latently	ADV	RB	_	_	_	_	_
35	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	U1	u1	NOUN	NN	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	line	line	NOUN	NN	Number=Sing	_	_	_	_
40	show	show	NOUN	NN	Number=Sing	_	_	_	_
41	that	that	PRON	WDT	PronType=Rel	_	_	_	_
42	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	p24	p24	NUM	CD	NumType=Card	_	_	_	_
52	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
53	measurement	measurement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
61	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	,	_	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
67	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9284
# text = These observations can be linked with the inhibition of NF-kappa B activation when uninfected monocytes are induced by either tumor necrosis factor alpha (TNF-alpha) phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	uninfected	uninfect	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	either	either	DET	DT	_	_	_	_	_
22	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
23	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
32	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
35	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
37	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9285
# text = Document 0030011776 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011776	0030011776	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9286
# text = Tissue-specific activity of the gammac chain gene promoter depends upon an Ets binding site and is regulated by GA-binding protein.
1	Tissue-	Tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	GA	Ga	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9287
# text = The gammac chain is a subunit of multiple cytokine receptors (interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15), the expression of which is restricted to hematopoietic lineages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	which	which	PRON	WDT	PronType=Rel	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
45	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9288
# text = A defect in gammac leads to the X-linked severe combined immunodeficiency characterized by a block in T cell differentiation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	gammac	gammac	ADJ	JJ	Degree=Pos	_	_	_	_
5	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	X	x	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
12	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	block	block	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9289
# text = In order to better characterize the human gammac promoter and define the minimal tissue-specific promoter region, progressive 5'-deletion constructs of a segment extending 1053 base pairs upstream of the major transcription start site were generated and tested for promoter activity in various hematopoietic and nonhematopoietic cell types.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	better	better	ADV	RBR	Degree=Cmp	_	_	_	_
5	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
14	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
25	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
29	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
30	1053	1053	NUM	CD	NumType=Card	_	_	_	_
31	base	base	NOUN	NN	Number=Sing	_	_	_	_
32	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
33	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	start	start	NOUN	NN	Number=Sing	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
49	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	nonhematopoietic	nonhematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
52	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
53	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9290
# text = The -1053/+34 construct allowed promoter activity only in cells of hematopoietic origin, and tissue specificity was conserved in all other constructs tested.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1053/+34	1053/+34	NUM	CD	NumType=Card	_	_	_	_
4	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
5	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	only	only	ADV	RB	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
13	origin	origin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
17	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	all	all	DET	DT	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
24	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9291
# text = The region downstream of -90 appeared critical for basal promoter activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	90	90	NUM	CD	NumType=Card	_	_	_	_
7	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9292
# text = It contains two potential Ets binding sites conserved in the murine gammac promoter gene, one of which was found essential for functional promoter activity as determined by mutational analysis.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
5	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
12	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	mutational	mutational	ADJ	JJ	Degree=Pos	_	_	_	_
30	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9293
# text = The functional Ets binding site was found to bind Ets family proteins, principally GA-binding protein and Elf-1 and could be transactivated by GABPalpha and -beta synergistically.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	Ets	et	PROPN	NNPS	Number=Plur	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	Ets	Ets	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	principally	principally	ADV	RB	_	_	_	_	_
15	GA	ga	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Elf	Elf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	GAB	GAB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	Palpha	Palpha	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	beta	beof	NOUN	NN	Number=Sing	_	_	_	_
33	synergistically	synergistically	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9294
# text = These results indicate that, as already reported for the IL2Rbeta promoter, GA-binding protein is an essential component of gammac basal promoter activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	as	as	SCONJ	IN	_	_	_	_	_
7	already	already	ADV	RB	_	_	_	_	_
8	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL2	IL2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	GA	Ga	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	component	component	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
25	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9295
# text = Although GABP expression is not restricted to the hematopoietic lineage, its interaction with other specific factors may contribute to the tissue-specific expression of the gammac gene.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
10	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	gammac	gammac	ADJ	JJ	Degree=Pos	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9296
# text = Document 0030011779 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011779	0030011779	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9297
# text = Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
20	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9298
# text = Recruitment and extravasation of T cells through the blood-brain barrier are favored by adhesion molecule-mediated interactions of circulating T cells with endothelial cells.
1	Recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	extravasation	extravasation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	brain	brain	NOUN	NN	Number=Sing	_	_	_	_
12	barrier	barrier	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	favored	favore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	SCONJ	IN	_	_	_	_	_
22	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9299
# text = Since a common pathological finding in human T-cell leukemia virus type 1 (HTLV-1)-associated diseases is the infiltration of HTLV-1-infected T lymphocytes into various organs, we have looked for the profile of adhesion molecules expressed by HTLV-1-transformed T cells.
1	Since	since	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
4	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
5	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	X	LS	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	into	into	ADP	IN	_	_	_	_	_
33	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
34	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
37	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	looked	look	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
44	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
45	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	T	t	PROPN	NNP	Number=Sing	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9300
# text = Flow cytometry analysis indicated that these cells were expressing high levels of vascular cell adhesion molecule 1 (VCAM-1 [CD106]), a 110-kDa member of the immunoglobulin gene superfamily, first identified on endothelial cells stimulated with inflammatory cytokines.
1	Flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	expressing	expresse	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
16	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CD106	CD106	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	110	110	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-kDa	-kDa	NOUN	NN	Number=Sing	_	_	_	_
30	member	member	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	first	first	ADV	RB	_	_	_	_	_
38	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
45	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9301
# text = This adhesion molecule was also expressed by T cells obtained from one patient with HTLV-1-associated myelopathy/tropical spastic paraparesis but not by activated T cells isolated from one normal blood donor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	myelopathy	myelopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	tropical	tropical	ADJ	JJ	Degree=Pos	_	_	_	_
23	spastic	spastic	ADJ	JJ	Degree=Pos	_	_	_	_
24	paraparesis	paraparesis	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
35	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
36	donor	donor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9302
# text = The role of the viral trans-activator Tax protein in the induction of VCAM-1 was first indicated by the detection of this adhesion molecule on Jurkat T-cell clones stably expressing the tax gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	first	first	ADV	RB	_	_	_	_	_
20	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
33	stably	stably	ADV	RB	_	_	_	_	_
34	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9303
# text = The effect of Tax on VCAM-1 gene transcription was next confirmed in JPX-9 cells, a subclone of Jurkat cells, carrying the tax sequences under the control of an inducible promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	next	next	ADV	RB	_	_	_	_	_
13	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	JPX	JPX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	9	9	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
29	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
30	under	under	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9304
# text = Furthermore, deletion and mutation analyses of the VCAM-1 promoter performed with chloramphenicol acetyltransferase constructs revealed that Tax was trans activating the VCAM-1 promoter via two NF-kappaB sites present at bp -72 and -57 in the VCAM-1 gene promoter, with both of them being required for the Tax-induced expression of this adhesion molecule.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
16	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
17	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
18	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
23	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	via	via	ADP	IN	_	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	72	72	NUM	CD	NumType=Card	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	57	57	NUM	CD	NumType=Card	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	both	both	DET	DT	_	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
55	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
56	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
65	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
66	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9305
# text = Finally, gel mobility shift assays demonstrated the nuclear translocation of proteins specifically bound to these two NF-kappaB motifs, confirming that VCAM-1 was induced on Tax-expressing cells in a kappaB-dependent manner.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	gel	gel	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	confirming	confirm	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
40	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9306
# text = Collectively, these results therefore suggest that the exclusive Tax-induced expression of VCAM-1 on T cells may represent a pivotal event in the progression of HTLV-1-associated diseases.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	_
6	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	exclusive	exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
10	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
25	event	event	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9307
# text = Document 0030011783 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011783	0030011783	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9308
# text = Rel/NF-kappa B transcription factors and the control of apoptosis.
1	Rel/NF	Rel/nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9309
# text = The process of apoptosis is used to eliminate unwanted cells from a wide variety of organisms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	process	process	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	eliminate	eliminate	VERB	VB	VerbForm=Inf	_	_	_	_
9	unwanted	unwanted	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
14	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	organisms	organism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9310
# text = Various extracellular signals, often converging in common intracellular pathways, can induce apoptosis in a cell-type-specific fashion.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	often	often	ADV	RB	_	_	_	_	_
6	converging	converge	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	type-	type-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9311
# text = Recent work from several laboratories has demonstrated that Rel/NF-kappa B transcription factors regulate apoptosis in many cell types.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	laboratories	laboratory	NOUN	NNS	Number=Plur	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9312
# text = In most cells, Rel/NF-kappa B transcription factors appear to mediate survival signals that protect cells from apoptosis; however, under some circumstances, activation of these factors may also promote apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	protect	protect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	some	some	DET	DT	_	_	_	_	_
28	circumstances	circumstance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
35	also	also	ADV	RB	_	_	_	_	_
36	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
37	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9313
# text = Document 0030011790 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011790	0030011790	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9314
# text = Reactive oxygen species and antioxidants in inflammatory diseases.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
3	species	species	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9315
# text = This paper aims to review the role of free radical-induced tissue damage and antioxidant defence mechanisms in inflammatory diseases that involve pathogenic processes similar to the periodontal diseases.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
3	aims	aim	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	review	review	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
10	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
14	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
17	defence	defence	NOUN	NN	Number=Sing	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	pathogenic	pathogenic	NOUN	NN	Number=Sing	_	_	_	_
25	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
26	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	periodontal	periodontal	ADJ	JJ	Degree=Pos	_	_	_	_
30	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9316
# text = There is a clearly defined and substantial role for free radicals or reactive oxygen species (ROS) in periodontitis, but little research has been performed in this area.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	clearly	clearly	ADV	RB	_	_	_	_	_
5	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
11	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
14	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
15	species	species	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	periodontitis	periodontitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
24	research	research	NOUN	NN	Number=Sing	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	area	area	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9317
# text = This paper reviews the considerable data available relating ROS activity and antioxidant defence to inflammatory diseases and attempts to draw parallels with periodontitis, in an effort to stimulate more periodontal research in this important area.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
3	reviews	review	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
6	data	data	NOUN	NN	Number=Sing	_	_	_	_
7	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
8	relating	relat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	ROS	Ros	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
13	defence	defence	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	attempts	attempt	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	draw	draw	VERB	VB	VerbForm=Inf	_	_	_	_
21	parallels	parallel	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	periodontitis	periodontitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	effort	effort	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
30	more	more	ADV	RBR	_	_	_	_	_
31	periodontal	periodontal	ADJ	JJ	Degree=Pos	_	_	_	_
32	research	research	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
36	area	area	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9318
# text = The recent discovery of the transcription factor nuclear factor kappa B (NF-kappa B) is reviewed and several potential pathways for cytokine-induced periodontal tissue damage, mediated by NF-kappa B1 are discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	discovery	discovery	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	reviewed	review	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
23	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	periodontal	periodontal	ADJ	JJ	Degree=Pos	_	_	_	_
29	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
30	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9319
# text = Emphasis is placed on cytokines that have been studied in periodontitis, principally TNF-alpha, IL-1, IL-6, IL-8 and beta-interferon.
1	Emphasis	Emphasis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	placed	place	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	periodontitis	periodontitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	principally	principally	ADV	RB	_	_	_	_	_
14	TNF	Tnf	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	IL	il	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	8	8	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9320
# text = The link between cellular production of such important mediators of inflammation and the antioxidant (AO) thiols, cysteine and reduced glutathione (GSH), is discussed and it is hypothesised that NF-kappa B antagonists may offer important therapeutic benefits.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	link	link	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	AO	AO	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	thiols	thiol	INTJ	UH	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	cysteine	cysteine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	discussed	discussed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	hypothesised	hypothesise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
40	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
41	offer	offer	VERB	VB	VerbForm=Inf	_	_	_	_
42	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
43	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
44	benefits	benefit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9321
# text = Document 0030011791 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011791	0030011791	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9322
# text = A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	interferon	interferon	ADP	IN	_	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	Pip/LSIRF	Pip/LSIRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	negatively	negatively	ADV	RB	_	_	_	_	_
16	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9323
# text = We have isolated a novel cDNA clone encoding interferon (IFN) consensus sequence-binding protein in adult T-cell leukemia cell line or activated T cells (ICSAT); this protein is the human homolog of the recently cloned Pip/LSIRF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
7	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
8	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	;	;	PUNCT	,	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	recently	recently	ADV	RB	_	_	_	_	_
42	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	Pip/LSIRF	Pip/LSIRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9324
# text = ICSAT is structurally most closely related to the previously cloned ICSBP, a member of the IFN regulatory factor (IRF) family of proteins that binds to interferon consensus sequences (ICSs) found in many promoters of the IFN-regulated genes.
1	ICSAT	Icsat	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	structurally	structurally	ADV	RB	_	_	_	_	_
4	most	most	ADV	RBS	_	_	_	_	_
5	closely	closely	ADV	RB	_	_	_	_	_
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	previously	previously	ADV	RB	_	_	_	_	_
10	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	ICSBP	ICSBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	member	member	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
18	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	interferon	interferon	VERB	VB	VerbForm=Inf	_	_	_	_
30	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
31	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	ICSs	ICSs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
38	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9325
# text = Among T-cell lines investigated, ICSAT was abundantly expressed in human T-cell leukemia virus type 1 (HTLV-1)-infected T cells.
1	Among	among	ADP	IN	_	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	abundantly	abundantly	ADV	RB	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9326
# text = When the HTLV-1 tax gene was expressed or phorbol myristake acetate-A23187 stimulation was used, ICSAT expression was induced in Jurkat cells which otherwise do not express ICSAT.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	expressed	express	ADJ	JJ	Degree=Pos	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
12	myristake	myristake	NOUN	NN	Number=Sing	_	_	_	_
13	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	A23187	A23187	NUM	CD	NumType=Card	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	ICSAT	ICSAT	SCONJ	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	otherwise	otherwise	ADV	RB	_	_	_	_	_
29	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
32	ICSAT	Icsat	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9327
# text = When the binding of ICSAT to four different ICSs was tested, the relative differences in binding affinities for those ICSs were determined.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	four	four	NUM	CD	NumType=Card	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	ICSs	ICS	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
15	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	affinities	affinity	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	ICSs	ICSs	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	determined	determine	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9328
# text = To study the functional role of ICSAT, we performed cotransfection experiments with the human embryonal carcinoma cell line N-Tera2.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
12	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	embryonal	embryonal	ADJ	JJ	Degree=Pos	_	_	_	_
17	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	N	and	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Tera2	tera2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9329
# text = ICSAT was demonstrated to possess repressive function over the gene activation induced by IFN stimulation or by IRF-1 cotransfection.
1	ICSAT	ICSAT	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	possess	possess	VERB	VB	VerbForm=Inf	_	_	_	_
6	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	over	over	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9330
# text = Such repressive function is similar to that seen in IRF-2 or ICSBP.
1	Such	such	DET	PDT	_	_	_	_	_
2	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	ICSBP	Icsbp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9331
# text = However, we have found that ICSAT has a different repressive effect from that of IRF-2 or ICSBP in some IFN-responsive reporter constructs.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	ICSAT	Icsat	PRON	WP	PronType=Int	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	ICSBP	Icsbp	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	some	some	DET	DT	_	_	_	_	_
23	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
26	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
27	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9332
# text = These results suggest that a novel mechanism of gene regulation by "differential repression" is used by multiple members of repressor proteins with different repressive effects on the IFN-responsive genes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
13	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
14	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	"	"	PUNCT	''	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9333
# text = Document 0030011794 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011794	0030011794	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9334
# text = Transcriptional regulation during myelopoiesis.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	during	during	ADP	IN	_	_	_	_	_
4	myelopoiesis	myelopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9335
# text = The coordinated production of all blood cells from a common stem cell is a highly regulated process involving successive stages of commitment and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	production	production	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	all	all	DET	DT	_	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
11	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	highly	highly	ADV	RB	_	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	process	process	NOUN	NN	Number=Sing	_	_	_	_
18	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
19	successive	successive	ADJ	JJ	Degree=Pos	_	_	_	_
20	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9336
# text = From analyses of mice deficient in transcription factor genes and from the characterizations of chromosome breakpoints in human leukemias, it has become evident that transcription factors are important regulators of hematopoiesis.
1	From	from	ADP	IN	_	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
5	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	characterizations	characterization	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	chromosome	chromosome	DET	DT	_	_	_	_	_
16	breakpoints	breakpoint	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
30	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	hematopoiesis	hematopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9337
# text = During myelopoiesis, which includes the development of granulocytic and monocytic lineages, transcription factors from several families are active, including AML1/CBF beta, C/EBP, Ets, c-Myb, HOX, and MZF-1.
1	During	during	ADP	IN	_	_	_	_	_
2	myelopoiesis	myelopoiesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	development	development	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
18	families	family	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	AML1/	AML1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
24	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
25	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	C/	c/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
28	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	HOX	HOX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	MZF	MZF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9338
# text = Few of these factors are expressed exclusively in myeloid cells; instead it appears that they cooperatively regulate transcription of myeloid-specific genes.
1	Few	few	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	exclusively	exclusively	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	instead	instead	ADV	RB	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
14	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	cooperatively	cooperatively	ADV	RB	_	_	_	_	_
18	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9339
# text = Here we discuss recent advances in transcriptional regulation during myelopoiesis.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
5	advances	advance	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	myelopoiesis	myelopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9340
# text = Document 0030011795 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011795	0030011795	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9341
# text = The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
13	oncogenesis	oncogenesis	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9342
# text = Rel/NF-kappa B is a ubiquitous transcription factor that consists of multiple polypeptide subunits, and is subject to complex regulatory mechanisms that involve protein-protein interactions, phosphorylation, ubiquitination, proteolytic degradation, and nucleocytoplasmic translocation.
1	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
17	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	complex	complex	VERB	VB	VerbForm=Inf	_	_	_	_
24	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	ubiquitination	ubiquitination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	nucleocytoplasmic	nucleocytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
41	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9343
# text = The sophisticated control of Rel/NF-kappa B activity is not surprising since this transcription factor is involved in a wide array of cellular responses to extracellular cues, associated with growth, development, apoptosis, and pathogen invasion.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sophisticated	sophisticate	ADJ	JJ	Degree=Pos	_	_	_	_
3	control	control	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	surprising	surprising	ADJ	JJ	Degree=Pos	_	_	_	_
15	since	since	SCONJ	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
24	array	array	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	cues	cue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	pathogen	pathogen	NOUN	NN	Number=Sing	_	_	_	_
42	invasion	invasion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9344
# text = Thus, it is not unexpected that this versatile cellular homeostatic switch would be affected by a variety of viral pathogens, which have evolved mechanisms to utilize various aspects of Rel/NF-kappa B activity to facilitate their replication, cell survival and possibly evasion of immune responses.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	unexpected	unexpect	ADJ	JJ	Degree=Pos	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	versatile	versatile	NOUN	NN	Number=Sing	_	_	_	_
10	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
11	homeostatic	homeostatic	ADJ	JJ	Degree=Pos	_	_	_	_
12	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
13	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
21	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	evolved	evolve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	utilize	utilize	VERB	VB	VerbForm=Inf	_	_	_	_
29	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
30	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
41	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
45	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	possibly	possibly	ADV	RB	_	_	_	_	_
48	evasion	evasion	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
51	responses	respons	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9345
# text = This review will cover the molecular mechanisms that are utilized by mammalian oncogenic viruses to affect the activity of Rel/NF-kappa B transcription factors and the role of Rel/NF-kappa B in the regulation of viral gene expression and replication.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	review	review	NOUN	NN	Number=Sing	_	_	_	_
3	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
4	cover	cover	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
13	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
14	viruses	virus	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	role	role	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Rel/	Relith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-kappa	-kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9346
# text = Document 0030011800 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011800	0030011800	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9347
# text = Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cyclooxygenase	cyclooxygenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	trifluoromethyl	trifluoromethyl	NOUN	NN	Number=Sing	_	_	_	_
11	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	triflusal	triflusal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
19	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	deacetylated	deacetylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	hydroxy	hydroxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	trifluoromethylbenzoic	trifluoromethylbenzoic	ADJ	JJ	Degree=Pos	_	_	_	_
30	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9348
# text = The therapeutic potential of drugs that block the induction of cyclooxygenase-2 has been emphasized.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
3	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	block	block	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cyclooxygenase	cyclooxygenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	emphasized	emphasize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9349
# text = When two 4-trifluoromethyl salicylate derivatives [2-acetoxy-4-trifluoromethyl-benzoic
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	trifluoromethyl	trifluoromethyl	NOUN	NN	Number=Sing	_	_	_	_
6	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
7	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
8	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	acetoxy	acetoxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	trifluoromethyl	trifluoromethyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-benzoic	-benzoic	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9350
# text = acid (triflusal) and its deacetylated metabolite 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)] were compared with aspirin and sodium salicylate as cyclooxygenase-2 (COX-2) inhibitors, we observed that in bacterial lipopolysaccharide-activated human blood, triflusal, aspirin, and HTB, but not sodium salicylate, inhibited COX-2-mediated prostaglandin E2 (PGE2) production (IC50 = 0.16, 0.18, 0.39, and >10 mM, respectively).
1	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	triflusal	triflusal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	deacetylated	deacetylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	hydroxy	hydroxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	trifluoromethylbenzoic	trifluoromethylbenzoic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HTB	HTB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	]	]	PUNCT	-RRB-	_	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
27	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	cyclooxygenase	cyclooxygenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	COX	Cox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
44	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	triflusal	triflusal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	HTB	HTB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	but	but	CCONJ	CC	_	_	_	_	_
58	not	not	ADV	RB	_	_	_	_	_
59	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
60	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
63	COX	Cox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
68	prostaglandin	prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
69	E2	E2	NUM	CD	NumType=Card	_	_	_	_
70	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
71	PGE2	PGE2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	)	)	PUNCT	-RRB-	_	_	_	_	_
73	production	production	NOUN	NN	Number=Sing	_	_	_	_
74	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
75	IC50	IC50	NUM	CD	NumType=Card	_	_	_	_
76	=	=	SYM	SYM	_	_	_	_	_
77	0.16	0.16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
78	,	,	PUNCT	,	_	_	_	_	_
79	0.18	0.18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
80	,	,	PUNCT	,	_	_	_	_	_
81	0.39	0.39	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	and	and	CCONJ	CC	_	_	_	_	_
84	>10	>10	NUM	CD	NumType=Card	_	_	_	_
85	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
86	,	,	PUNCT	,	_	_	_	_	_
87	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
88	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
89	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9351
# text = However, only triflusal and aspirin inhibited purified COX-2 enzyme.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	triflusal	triflusal	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	aspirin	aspirin	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	COX	Cox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9352
# text = To test this apparent discrepancy, we realized that HTB and triflusal (but neither aspirin nor salicylate) produced a concentration-dependent inhibition of COX-2 protein expression in peripheral human mononuclear cells.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
5	discrepancy	discrepancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	realized	realize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	HTB	Htb	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	triflusal	triflusal	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	but	but	CCONJ	CC	_	_	_	_	_
15	neither	neither	DET	DT	_	_	_	_	_
16	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
17	nor	nor	CCONJ	CC	_	_	_	_	_
18	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	COX	cox	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9353
# text = This observation was further confirmed in a rat air pouch model in vivo, in which both aspirin and triflusal inhibited PGE2 production (ID50 = 18.9 and 11.4 mg/kg p.o., respectively) but only triflusal-treated animals showed a decrease in COX-2 expression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
9	air	air	NOUN	NN	Number=Sing	_	_	_	_
10	pouch	pouch	NOUN	NN	Number=Sing	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	triflusal	triflusal	NOUN	NN	Number=Sing	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	ID50	ID50	NUM	CD	NumType=Card	_	_	_	_
26	=	=	SYM	SYM	_	_	_	_	_
27	18.9	18.9	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	11.4	11.4	NUM	CD	NumType=Card	_	_	_	_
30	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	kg	kg	NOUN	NN	Number=Sing	_	_	_	_
33	p.o.	p.o.	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	only	only	ADV	RB	_	_	_	_	_
39	triflusal	triflusal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
43	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	COX	cox	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	2	2	NUM	CD	NumType=Card	_	_	_	_
50	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9354
# text = This different behavior may be, at least in part, due to the ability of HTB and triflusal to block the activation of the transcription factor nuclear factor-kappaB to a higher extent than aspirin and sodium salicylate.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	due	due	ADP	IN	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HTB	HTB	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	triflusal	triflusal	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
35	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
36	than	than	ADP	IN	_	_	_	_	_
37	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
40	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9355
# text = Thus, in addition to inhibiting the COX-2 activity at therapeutic concentrations, triflusal is able to block through its metabolite HTB the expression of new enzyme, and hence the resumption of PGE2 synthesis.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	SCONJ	IN	_	_	_	_	_
6	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	COX	cox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
14	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	triflusal	triflusal	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
24	HTB	Htb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
29	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	hence	hence	ADV	RB	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	resumption	resumption	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
37	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9356
# text = Triflusal and HTB may exert beneficial effects in processes in which de novo COX-2 expression is involved and, in a broader sense, in pathological situations in which genes under nuclear factor-kappaB control are up-regulated.
1	Triflusal	Triflusal	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	HTB	HTB	PROPN	NNP	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
6	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	de	de	PROPN	NNP	Number=Sing	_	_	_	_
13	novo	novo	ADP	IN	_	_	_	_	_
14	COX	cox	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	broader	broader	ADJ	JJR	Degree=Cmp	_	_	_	_
25	sense	sense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
29	situations	situation	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	genes	gene	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	under	under	ADP	IN	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
38	control	control	NOUN	NN	Number=Sing	_	_	_	_
39	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9357
# text = Document 0030011804 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011804	0030011804	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9358
# text = Transcriptional regulation of T lymphocyte development and function.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
6	development	development	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9359
# text = The development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular signaling molecules, and nuclear transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	tightly	tightly	ADV	RB	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
13	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
25	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9360
# text = Since 1988, several families of functionally important T cell transcription factors have been identified.
1	Since	since	ADP	IN	_	_	_	_	_
2	1988	1988	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	families	family	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	functionally	functionally	ADV	RB	_	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9361
# text = These include the Ikaros, LKLF, and GATA3 zinc-finger proteins; the Ets, CREB/ATF, and NF-kappa B/Rel/NFAT transcription factors; the Stat proteins; and HMG box transcription factors such as LEF1, TCF1, and Sox4.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Ikaros	Ikaros	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	LKLF	LKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	GATA3	GATA3	NUM	CD	NumType=Card	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Rel/NFAT	Rel/nfat	NOUN	NN	Number=Sing	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	_
38	box	box	NOUN	NN	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
41	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	LEF1	LEF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	TCF1	TCF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	Sox4	Sox4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9362
# text = In this review, we summarize our current understanding of the transcriptional regulation of T cell development and function with particular emphasis on the results of recent gene targeting and transgenic experiments.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	summarize	summarize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
8	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
9	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	development	development	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
22	emphasis	emphasis	NOUN	NN	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	results	result	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
32	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9363
# text = In addition to increasing our understanding of the molecular pathways that regulate T cell development and function, these results have suggested novel targets for genetic and pharmacological manipulation of T cell immunity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	SCONJ	IN	_	_	_	_	_
4	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	T	t	NUM	CD	NumType=Card	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
24	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
29	manipulation	manipulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9364
# text = Document 0030011812 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011812	0030011812	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9365
# text = A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	product	product	NOUN	NN	Number=Sing	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	p50/p105	p50/p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9366
# text = A Rel-related, mitogen-inducible, kappa B-binding protein has been cloned as an immediate-early activation gene of human peripheral blood T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	Rel-related	Rel-related	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mitogen	mitogen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B-	B-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9367
# text = The cDNA has an open reading frame of 900 amino acids capable of encoding a 97-kDa protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
6	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
7	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	900	900	NUM	CD	NumType=Card	_	_	_	_
10	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
11	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
12	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
13	of	of	SCONJ	IN	_	_	_	_	_
14	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	97	97	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9368
# text = This protein is most similar to the 105-kDa precursor polypeptide of p50-NF-kappa B.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	most	most	ADV	RBS	_	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
12	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9369
# text = Like the 105-kDa precursor, it contains an amino-terminal Rel-related domain of about 300 amino acids and a carboxy-terminal domain containing six full cell cycle or ankyrin repeats.
1	Like	like	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
6	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
9	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
14	Rel-	rel-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	about	about	ADV	RB	_	_	_	_	_
19	300	300	NUM	CD	NumType=Card	_	_	_	_
20	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
21	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
29	six	six	NUM	CD	NumType=Card	_	_	_	_
30	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
35	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9370
# text = In vitro-translated proteins, truncated downstream of the Rel domain and excluding the repeats, bind kappa B sites.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADV	RB	_	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	excluding	exclude	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	bind	bind	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9371
# text = We refer to the kappa B-binding, truncated protein as p50B by analogy with p50-NF-kappa B and to the full-length protein as p97.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	refer	refer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	p50B	p50b	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	analogy	analogy	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	length	length	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	p97.	p97.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9372
# text = p50B is able to form heteromeric kappa B-binding complexes with RelB, as well as with p65 and p50, the two subunits of NF-kappa B. Transient-transfection experiments in embryonal carcinoma cells demonstrate a functional cooperation between p50B and RelB or p65 in transactivation of a reporter plasmid dependent on a kappa B site.
1	p50B	p50b	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
6	heteromeric	heteromeric	ADJ	JJ	Degree=Pos	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	RelB	Relb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	well	well	ADV	RB	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
31	Transient	Transient	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
34	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	embryonal	embryonal	ADJ	JJ	Degree=Pos	_	_	_	_
37	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
42	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
43	between	between	ADP	IN	_	_	_	_	_
44	p50B	p50b	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
47	or	or	CCONJ	CC	_	_	_	_	_
48	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
54	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
55	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
56	on	on	ADP	IN	_	_	_	_	_
57	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
58	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
59	B	b	NOUN	NN	Number=Sing	_	_	_	_
60	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9373
# text = The data imply the existence of a complex family of NF-kappa B-like transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9374
# text = Document 0030011814 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011814	0030011814	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9375
# text = MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells.
1	MEK1	Mek1	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9376
# text = TCR engagement stimulates the activation of the protein kinase Raf-1.
1	TCR	Tcr	ADJ	JJR	Degree=Cmp	_	_	_	_
2	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
3	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9377
# text = Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and activates the MAP kinases/extracellular signal regulated kinases, ERK1 and ERK2.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	phosphorylates	phosphorylate	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MEK1	Mek1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
32	phosphorylates	phosphorylate	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
37	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
40	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
41	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	ERK1	Erk1	PROPN	NNP	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	ERK2	Erk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9378
# text = Raf-1 activity promotes IL-2 production in activated T lymphocytes.
1	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9379
# text = Therefore, we sought to determine whether MEK1 and ERK activities also stimulate IL-2 gene transcription.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	MEK1	Mek1	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	ERK	Erk	PROPN	NNP	Number=Sing	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9380
# text = Expression of constitutively active Raf-1 or MEK1 in Jurkat T cells enhanced the stimulation of IL-2 promoter-driven transcription stimulated by a calcium ionophore and PMA, and together with a calcium ionophore the expression of each protein was sufficient to stimulate NF-AT activity.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	constitutively	constitutively	ADV	RB	_	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	MEK1	MEK1	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
29	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	together	together	ADV	RB	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
38	ionophore	ionophore	SCONJ	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	each	each	DET	DT	_	_	_	_	_
43	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
46	to	to	PART	TO	_	_	_	_	_
47	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
48	NF	Nf	ADV	RB	_	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
51	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9381
# text = Expression of MEK1-interfering mutants inhibited the stimulation of IL-2 promoter-driven transcription and blocked the ability of constitutively active Ras and Raf-1 to costimulate NF-AT activity with a calcium ionophore.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	MEK1	MEK1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
6	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
7	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	constitutively	constitutively	ADV	RB	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	Ras	Ras	PROPN	NNPS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	costimulate	costimulate	VERB	VB	VerbForm=Inf	_	_	_	_
32	NF	Nf	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
39	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9382
# text = Expression of the MAP kinase-specific phosphatase, MKP-1, which blocks ERK activation, inhibited IL-2 promoter and NF-AT-driven transcription stimulated by a calcium ionophore and PMA, and in addition, MKP-1 neutralized the transcriptional enhancement caused by active Raf-1 and MEK1 expression.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	MKP	MKP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	AT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
35	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	MKP	MKP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	neutralized	neutralize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
50	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
53	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	MEK1	MEK1	NUM	CD	NumType=Card	_	_	_	_
58	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9383
# text = We conclude that the MAP kinase signal transduction pathway consisting of Raf-1, MEK1, and ERK1 and ERK2 functions in the stimulation IL-2 gene transcription in activated T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	MEK1	Mek1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	ERK1	ERK1	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	ERK2	ERK2	NUM	CD	NumType=Card	_	_	_	_
22	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9384
# text = Document 0030011815 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011815	0030011815	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9385
# text = Function and activation of NF-kappa B in the immune system.
1	Function	function	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9386
# text = NF-kappa B is a ubiquitous transcription factor.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9387
# text = Nevertheless, its properties seem to be most extensively exploited in cells of the immune system.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
6	seem	seem	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	most	most	ADV	RBS	_	_	_	_	_
10	extensively	extensively	ADV	RB	_	_	_	_	_
11	exploited	exploit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9388
# text = Among these properties are NF-kappa B's rapid posttranslational activation in response to many pathogenic signals, its direct participation in cytoplasmic/nuclear signaling, and its potency to activate transcription of a great variety of genes encoding immunologically relevant proteins.
1	Among	among	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	's	's	PART	POS	_	_	_	_	_
10	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
11	posttranslational	posttranslational	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
17	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
22	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
31	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	great	great	ADJ	JJ	Degree=Pos	_	_	_	_
39	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
42	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
43	immunologically	immunologically	ADV	RB	_	_	_	_	_
44	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
45	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9389
# text = In vertebrates, five distinct DNA binding subunits are currently known which might extensively heterodimerize, thereby forming complexes with distinct transcriptional activity, DNA sequence specificity, and cell type- and cell stage-specific distribution.
1	In	in	ADP	IN	_	_	_	_	_
2	vertebrates	vertebrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	five	five	NUM	CD	NumType=Card	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	currently	currently	ADV	RB	_	_	_	_	_
11	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	which	which	PRON	WDT	PronType=Int	_	_	_	_
13	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
14	extensively	extensively	ADV	RB	_	_	_	_	_
15	heterodimerize	heterodimerize	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	thereby	thereby	ADV	RB	_	_	_	_	_
18	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
19	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9390
# text = The activity of DNA binding NF-kappa B dimers is tightly controlled by accessory proteins called I kappa B subunits of which there are also five different species currently known in vertebrates.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	tightly	tightly	ADV	RB	_	_	_	_	_
13	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	there	there	PRON	EX	_	_	_	_	_
25	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	also	also	ADV	RB	_	_	_	_	_
27	five	five	NUM	CD	NumType=Card	_	_	_	_
28	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
29	species	species	NOUN	NNS	Number=Plur	_	_	_	_
30	currently	currently	ADV	RB	_	_	_	_	_
31	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vertebrates	vertebrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9391
# text = I kappa B proteins inhibit DNA binding and prevent nuclear uptake of NF-kappa B complexes.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9392
# text = An exception is the Bcl-3 protein which in addition can function as a transcription activating subunit in th nucleus.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	th	th	ADJ	JJ	Degree=Pos	_	_	_	_
21	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9393
# text = Other I kappa B proteins are rather involved in terminating NF-kappa B's activity in the nucleus.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
4	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	rather	rather	ADV	RB	_	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	terminating	terminat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	's	's	PART	POS	_	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9394
# text = The intracellular events that lead to the inactivation of I kappa B, i.e. the activation of NF-kappa B, are complex.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	benefit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	i.e.	i.e.	X	FW	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9395
# text = They involve phosphorylation and proteolytic reactions and seem to be controlled by the cells' redox status.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	seem	seem	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	'	's	PART	POS	_	_	_	_	_
16	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
17	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9396
# text = Interference with the activation or activity of NF-kappa B may be beneficial in suppressing toxic/septic shock, graft-vs-host reactions, acute inflammatory reactions, acute phase response, and radiation damage.
1	Interference	interference	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
17	toxic	toxic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
20	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	graft	graft	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	vs	versus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	host	host	NOUN	NN	Number=Sing	_	_	_	_
27	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
34	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	_
39	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9397
# text = The inhibition of NF-kappa B activation by antioxidants and specific protease inhibitors may provide a pharmacological basis for interfering with these acute processes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
19	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
25	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9398
# text = Document 0030011816 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011816	0030011816	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9399
# text = A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
3	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9400
# text = Recent studies have revealed that interactions between transcription factors play an important role in regulation of gene expression in eukaryotic cells.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9401
# text = To isolate cDNA clones that dominantly inhibit the DNA-binding activity of Oct-2, chosen as a representative factor, we have developed a novel screening system.
1	To	to	PART	TO	_	_	_	_	_
2	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
3	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	dominantly	dominantly	ADV	RB	_	_	_	_	_
7	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	chosen	chosen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	representative	representative	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
29	screening	screen	VERB	VBG	VerbForm=Ger	_	_	_	_
30	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9402
# text = This employs an Escherichia coli tester strain carrying a modified lac operon as a reporter gene, with the lac operator sequence replaced by an octamer sequence.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	employs	employ	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
5	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
6	tester	tester	NOUN	NN	Number=Sing	_	_	_	_
7	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
8	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	lac	lac	NOUN	NN	Number=Sing	_	_	_	_
12	operon	operon	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	lac	lac	ADJ	JJ	Degree=Pos	_	_	_	_
21	operator	operator	NOUN	NN	Number=Sing	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9403
# text = Oct-2 expressed in this tester strain represses the expression of the reporter gene and changes the phenotype of the cell from Lac+to Lac-.
1	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	tester	tester	NOUN	NN	Number=Sing	_	_	_	_
8	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
9	represses	repress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	changes	change	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	Lac	Lac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
26	to	to	ADP	IN	_	_	_	_	_
27	Lac	Lac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-.	-.	PUNCT	.	_	_	_	_	_

# sent_id = 9404
# text = Introduction of a cDNA expression library prepared from a human T-cell line into the Oct-2-harboring tester strain allowed selection of three Lac+clones out of 1 x 10(5) transformants.
1	Introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cDNA	cDNA	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	library	library	NOUN	NN	Number=Sing	_	_	_	_
7	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	_
14	into	into	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	harboring	harboring	NOUN	NN	Number=Sing	_	_	_	_
21	tester	tester	NOUN	NN	Number=Sing	_	_	_	_
22	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
23	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	three	three	NUM	CD	NumType=Card	_	_	_	_
27	Lac+	Lac+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
29	out	out	ADP	IN	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	x	x	SYM	SYM	_	_	_	_	_
33	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	transformants	transformant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9405
# text = One of them, hT86, encoding a putative zinc finger protein was found to derepress beta-galactosidase activity in the Oct-2-harboring tester strain at the transcriptional level.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	hT86	hT86	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
11	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	derepress	derepress	VERB	VB	VerbForm=Inf	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	galactosidase	galactosidase	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	harboring	harbor	NOUN	NN	Number=Sing	_	_	_	_
28	tester	tester	NOUN	NN	Number=Sing	_	_	_	_
29	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9406
# text = In gel mobility shift assays, hT86 attenuated the intensity of the retarded band composed of the octamer probe and Oct-2, suggesting a dominant negative effect on the DNA-binding activity of Oct-2.
1	In	in	ADP	IN	_	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	hT86	hT86	PROPN	NNP	Number=Sing	_	_	_	_
8	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	retarded	retarded	ADJ	JJ	Degree=Pos	_	_	_	_
14	band	band	NOUN	NN	Number=Sing	_	_	_	_
15	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
19	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9407
# text = The strategy described here provides a new approach for studying protein-protein interactions that govern the complex regulation of gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
3	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
8	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	SCONJ	IN	_	_	_	_	_
10	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
11	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	govern	govern	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9408
# text = Document 0030011827 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011827	0030011827	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9409
# text = Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB.
1	Tpl	Tpl	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-2	-2	NUM	CD	NumType=Card	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9410
# text = The Tpl-2 kinase activates the nuclear factor of activated T cells (NFAT) and induces IL-2 expression in T-cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tpl	Tpl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9411
# text = Here we show that the activation of the IL-2 promoter by Tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen-activated protein kinase (MAPK) or the calcineurin/NFAT pathways and is promoted by combinations of signaling molecules that activate these pathways.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
22	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
39	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
47	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
48	that	that	PRON	WDT	PronType=Rel	_	_	_	_
49	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
51	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9412
# text = We, therefore, conclude that signals generated by the convergence of the MAPK and the calcineurin/NFAT pathway are necessary and sufficient for the activation of the IL-2 promoter by Tpl-2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	conclude	conclude	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	convergence	convergence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9413
# text = The activation of both the IL-2 promoter and an NFAT-driven minimal promoter were shown to depend on signals transduced by Raf1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
23	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	Raf1	Raf1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9414
# text = However, it was only the IL-2 promoter whose activation by Tpl-2 was fully blocked by the dominant negative mutant MEK1S218/222A and the MEK1/MEK2 inhibitor PD098059.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	fully	fully	ADV	RB	_	_	_	_	_
19	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
24	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
25	MEK1S218/222A	MEK1S218/222a	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	MEK1	Mek1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	MEK2	MEK2	NUM	CD	NumType=Card	_	_	_	_
31	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
32	PD098059	PD098059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9415
# text = Since the activation of NFAT is MAPK-dependent these findings suggested that the activation of MAPK by Tpl-2 is either independent or only partially dependent on MEK1 and MEK2.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
12	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	either	either	CCONJ	CC	_	_	_	_	_
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	partially	partially	ADV	RB	_	_	_	_	_
28	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	MEK1	Mek1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	MEK2	Mek2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9416
# text = In addition, they suggested that the activation of the IL-2 promoter is under the control of not only NFAT but also a second factor whose activation is MEK-dependent.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
5	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	under	under	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	NFAT	Nfat	ADV	RB	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	MEK	Mek	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9417
# text = Experiments in COS-1 and EL-4 cells confirmed both hypotheses and revealed that the second factor activated by Tpl-2 is NF-kappaB.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	EL	EL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	hypotheses	hypothese	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9418
# text = While the activation of the IL-2 promoter and an NFAT-driven minimal promoter by Tpl-2 was fully blocked by the dominant negative mutant NFAT delta418, it was only partially blocked by the calcineurin inhibitor cyclosporin
1	While	while	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Tpl	Tpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	fully	fully	ADV	RB	_	_	_	_	_
23	blocked	blocked	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
29	NFAT	NFAT	NOUN	NN	Number=Sing	_	_	_	_
30	delta418	delta418	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	only	only	ADV	RB	_	_	_	_	_
35	partially	partially	ADV	RB	_	_	_	_	_
36	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
40	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
41	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9419
# text = A suggesting that the Tpl-2-mediated NFAT activation is under the control of a combination of calcineurin-dependent and independent pathways.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	suggesting	suggest	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Tpl	Tpl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	under	under	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	calcineurin-	calcineurin-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
24	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9420
# text = Both pathways were fully blocked by Bcl-2 or Bcl-X(L).
1	Both	both	DET	DT	_	_	_	_	_
2	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	fully	fully	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-X	-X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	L	L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9421
# text = Document 0030011829 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011829	0030011829	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9422
# text = Regulation of cytokine and cytokine receptor expression by glucocorticoids.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9423
# text = Glucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through inhibition of cytokine expression at the transcriptional and posttranscriptional levels.
1	Glucocorticoids	Glucocorticoid	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	GCS	GCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	profoundly	profoundly	ADV	RB	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
7	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
8	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	T	t	NUM	CD	NumType=Card	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
13	largely	largely	ADV	RB	_	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9424
# text = GCS were also reported to act indirectly by inducing transforming growth factor-beta expression, which in turn blocks T cell immunity.
1	GCS	Gc	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
7	indirectly	indirectly	ADV	RB	_	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
10	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
11	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
20	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9425
# text = In exerting their antiproliferative effects, GCS diffuse into target cells where they bind their cytoplasmic receptor, which in turn translocates to the nucleus where it inhibits transcription of cytokine genes through direct binding to the glucocorticoid response elements (GRE), which are located in the promoter region of cytokine genes or, alternatively, through antagonism of the action of transcription factors required for optimal transcriptional activation.
1	In	in	SCONJ	IN	_	_	_	_	_
2	exerting	exert	VERB	VBG	VerbForm=Ger	_	_	_	_
3	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	GCS	Gc	NOUN	NNS	Number=Plur	_	_	_	_
8	diffuse	diffuse	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	target	target	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	where	where	ADV	WRB	PronType=Int	_	_	_	_
13	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
14	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
22	translocates	translocate	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
26	where	where	ADV	WRB	PronType=Rel	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
28	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
33	through	through	ADP	IN	_	_	_	_	_
34	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	which	which	PRON	WDT	PronType=Rel	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
51	region	region	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
54	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
55	or	or	CCONJ	CC	_	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	alternatively	alternatively	ADV	RB	_	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	through	through	ADP	IN	_	_	_	_	_
60	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	action	action	NOUN	NN	Number=Sing	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
66	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
67	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
68	for	for	ADP	IN	_	_	_	_	_
69	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
70	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
71	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9426
# text = In contrast to their inhibitory effects on cytokine expression, GCS up-regulate cytokine receptor expression that correlates with enhanced cytokine effects on target cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	GCS	GCS	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	target	target	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9427
# text = In this review, we summarize the current state of knowledge of the mechanism of action of GCS, including the phenomenon of steroid-induced rebound, which ensues upon GCS withdrawal.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	summarize	summarize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
9	state	state	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	knowledge	knowledge	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	action	action	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GCS	GCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	rebound	rebound	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	ensues	ensue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	upon	upon	ADP	IN	_	_	_	_	_
32	GCS	GCS	PROPN	NNP	Number=Sing	_	_	_	_
33	withdrawal	withdrawal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9428
# text = Document 0030011833 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011833	0030011833	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9429
# text = Selenium-mediated inhibition of transcription factor NF-kappa B and HIV-1 LTR promoter activity.
1	Selenium-	Selenium-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9430
# text = The eukaryotic transcription factor NF-kappa B is involved in the inducible expression of various inflammatory genes as well as in HIV-1 replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADV	RB	_	_	_	_	_
20	well	well	ADV	RB	Degree=Pos	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9431
# text = Activation of NF-kappa B is induced by prooxidants and several stimuli eliciting oxidative stress, such as cytokines, lipopolysaccharide, UV irradiation and other mediators.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	prooxidants	prooxidant	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
14	eliciting	elicit	VERB	VBG	VerbForm=Ger	_	_	_	_
15	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
16	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
25	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9432
# text = Various antioxidants inhibit NF-kappa B activation in response to these stimuli.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
3	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9433
# text = In this study, we have investigated the effects of selenium, an integral component of glutathione peroxidase (GPX), on NF-kappa B activation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	integral	integral	ADJ	JJ	Degree=Pos	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
18	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GPX	GPX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9434
# text = In selenium-deprived Jurkat and ESb-L
1	In	in	ADP	IN	_	_	_	_	_
2	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	deprived	deprive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	ESb	ESb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	L	L	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 9435
# text = T lymphocytes, supplementation of selenium led to a substantial increase of GPX activity.
1	T	t	NOUN	NN	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	_
7	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GPX	GPX	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9436
# text = Analysis of DNA binding revealed that NF-kappa B activation in response to TNF was significantly inhibited under these conditions.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	under	under	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9437
# text = Likewise, reporter gene assays using luciferase constructs driven by the HIV-1 long terminal repeat showed a dose-dependent inhibition of NF-kappa B controlled gene expression by selenium.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
9	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	controlled	control	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9438
# text = The effects of selenium were specific for NF-kappa B, since the activity of the transcription factor AP-1 was not suppressed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	B	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9439
# text = These data suggest that selenium supplementation may be used to modulate the expression of NF-kappa B target genes and HIV-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	selenium	selenium	NOUN	NN	Number=Sing	_	_	_	_
6	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	target	target	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9440
# text = Document 0030011840 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011840	0030011840	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9441
# text = Soluble factors secreted by activated T-lymphocytes modulate the transcription of the immunosuppressive cytokine TGF-beta 2 in glial cells.
1	Soluble	Soluble	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9442
# text = Coordination of the immune response to injury or disease in the brain is postulated to involve bi-directional discourse between the immune system and the central nervous system.
1	Coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	brain	brain	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
17	bi-directional	bi-directional	ADJ	JJ	Degree=Pos	_	_	_	_
18	discourse	discourse	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
26	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9443
# text = This cross communication involves soluble mediators, including various growth factors, cytokines, and neuropeptides.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	_
3	communication	communication	NOUN	NN	Number=Sing	_	_	_	_
4	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	neuropeptides	neuropeptide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9444
# text = In this report, we demonstrate that the supernatant from activated T-lymphocytes is able to induce the transcription of a potent cytokine, TGF-beta 2 in glial cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
23	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9445
# text = The activating stimulus invokes signaling mechanisms distinct from known kinase or protease pathways.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
3	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
4	invokes	invoke	NOUN	NNS	Number=Plur	_	_	_	_
5	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	known	known	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9446
# text = Activation of TGF-beta 2 transcription correlates with the loss of binding activity for an 80 kDA glial labile repressor protein, GLRP, to a responsive region within the TFG-beta 2 promoter.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	SCONJ	IN	_	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	80	80	NUM	CD	NumType=Card	_	_	_	_
18	kDA	kDa	NOUN	NN	Number=Sing	_	_	_	_
19	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
20	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
21	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	GLRP	GLRP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	_
30	within	within	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	TFG	Tfg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9447
# text = Although GLRP shares some characteristics with the inducible transcription factor AP-1, it appears to be distinct from known AP-1 family members.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	GLRP	GLRP	PROPN	NNP	Number=Sing	_	_	_	_
3	shares	share	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	some	some	DET	DT	_	_	_	_	_
5	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9448
# text = These data along with previous observations demonstrating the potent immunosuppressive activity of TGF-beta 2, support a model for a feedback mechanism between the activated T-lymphocytes and astrocytes via TGF-beta 2 to regulate the immune response.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	along	along	ADV	RB	_	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
6	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrating	demonstrate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
10	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	model	model	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	between	between	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	via	via	ADP	IN	_	_	_	_	_
33	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
41	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9449
# text = Document 0030011843 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011843	0030011843	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9450
# text = Distinct DNase-I hypersensitive sites are associated with TAL-1 transcription in erythroid and T-cell lines.
1	Distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	TAL	Tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9451
# text = The tal-1 gene, frequently activated in human T-cell acute lymphoblastic leukemia (T-ALL), is expressed in the erythroid, megakaryocytic, and mast cell lineages during normal hematopoiesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	frequently	frequently	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
14	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	ALL	All	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	mast	mast	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
34	during	during	ADP	IN	_	_	_	_	_
35	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
36	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9452
# text = To gain further insight into the molecular mechanisms that control tal-1 expression, we investigated tal-1 chromatin structure in erythroid/megakaryocytic cell lines and in T-cell lines either with or without tal-1 rearrangements.
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	insight	insight	ADV	RB	_	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
8	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
22	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
34	either	either	CCONJ	CC	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	without	without	ADP	IN	_	_	_	_	_
38	tal	tal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9453
# text = Tal-1 transcription was shown to be monoallelic in Jurkat, a T-cell line that expresses tal-1 in the absence of apparent genomic alteration of the locus.
1	Tal	Tal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	line	line	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	expresses	express	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	tal	tal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
27	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
28	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9454
# text = Methylation studies indicated that the tal-15' GC-rich region behaves like a CpG island, hypomethylated in normal cells, and methylated de novo on transcriptionally inactive alleles in established cell lines.
1	Methylation	Methylation	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tal	tal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-15	-15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	PUNCT	``	_	_	_	_	_
9	GC	Gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	behaves	behave	NOUN	NNS	Number=Plur	_	_	_	_
14	like	like	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	CpG	CpG	PROPN	NNP	Number=Sing	_	_	_	_
17	island	island	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	hypomethylated	hypomethylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	methylated	methylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	de	de	X	FW	Foreign=Yes	_	_	_	_
27	novo	novo	ADV	RB	_	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
30	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
31	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9455
# text = Five major DNase-I hypersensitive sites (HS) were mapped in the tal-1 locus.
1	Five	five	NUM	CD	NumType=Card	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HS	H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9456
# text = HS I, IV, and V were exclusively observed in the erythroid/megakaryocytic cell lines that express tal-1 from the promoters 1a and 1b.
1	HS	h	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IV	iv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	V	V	PROPN	NNP	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	exclusively	exclusively	ADV	RB	_	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	a	a	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9457
# text = HS II was weak in hematopoietic cell lines, absent in Hela, and greatly enhanced in Jurkat, suggesting that this region might be implicated in the cis-activation of tal-1 promoter 1b in this cell line.
1	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
2	II	II	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Hela	Hela	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	greatly	greatly	ADV	RB	_	_	_	_	_
16	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cis-activation	cis-activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	b	b	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9458
# text = HS III was weak in HEL and Jurkat, and greatly enhanced in DU528, a T-cell line that bears a t (1;14) and initiates tal-1 transcription within exon 4.
1	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
2	III	III	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	HEL	HEL	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	greatly	greatly	ADV	RB	_	_	_	_	_
12	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	DU528	DU528	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	bears	bear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	t	t	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	1;14	1;14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	within	within	ADP	IN	_	_	_	_	_
34	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
35	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9459
# text = These results suggest that distinct regulatory elements are associated with the use of the different tal-1 promoters.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	use	use	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9460
# text = Document 0030011846 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011846	0030011846	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9461
# text = The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	sis/	sisith	SYM	SYM	_	_	_	_	SpaceAfter=No
19	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
32	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9462
# text = Transcriptional up-regulation of the c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene by the Tax protein of human T-cell leukemia virus type 1 has been implicated as one possible mechanism of cellular transformation by human T-cell leukemia virus type 1.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	sis/	sis/	SYM	NFP	_	_	_	_	SpaceAfter=No
9	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PDGF	Pdgf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	proto	proto	PART	TO	_	_	_	_	SpaceAfter=No
22	-oncogene	-oncogene	VERB	VB	VerbForm=Inf	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
32	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
33	type	type	NOUN	NN	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	one	one	NUM	CD	NumType=Card	_	_	_	_
40	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
41	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
44	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
47	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
50	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
51	type	type	NOUN	NN	Number=Sing	_	_	_	_
52	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9463
# text = In previous work, we identified an essential site in the c-sis/PDGF-B promoter, Tax-responsive element 1 (TRE1), necessary for transactivation by Tax.
1	In	in	ADP	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	c-sis/PDGF	c-sis/pdgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TRE1	TRE1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9464
# text = We also identified Sp1, Sp3, and NGFI-A/Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Sp3	Sp3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	TRE1	TRE1	PROPN	NNP	Number=Sing	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
27	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
28	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9465
# text = In the present work, we have investigated the mechanism(s) whereby Tax transactivates the c-sis/PDGF-B proto-oncogene.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	s	s	X	AFX	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	whereby	whereby	ADJ	JJ	Degree=Pos	_	_	_	_
15	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
16	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	c-sis/PDGF	c-sis/pdgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	proto-oncogene	proto-oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9466
# text = In vitro transcription assays showed that Tax was able to significantly increase the transcriptional activity of a template containing the -257 to +74 region of the c-sis/PDGF-B promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	template	template	NOUN	NN	Number=Sing	_	_	_	_
19	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	257	257	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
25	74	74	NUM	CD	NumType=Card	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	c-sis/PDGF-B	c-sis/pdgf-b	ADJ	JJ	Degree=Pos	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9467
# text = Electrophoretic mobility shift assay analysis showed that Tax increased the DNA binding activity of both Sp1 and NGFI-A/Egr-1 using a TRE1 probe.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	TRE1	tRE1	NUM	CD	NumType=Card	_	_	_	_
28	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9468
# text = Analysis of Tax mutants showed that two mutants, IEXC29S and IEXL320G, were unable to significantly transactivate the c-sis/PDGF-B promoter.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
4	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IEXC29	IEXC29	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	S	S	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IEXL320G	IEXL320G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	significantly	significantly	ADV	RB	_	_	_	_	_
19	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	c-sis/PDGF	c-sis/pdgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9469
# text = Finally, co-immunoprecipitation analysis revealed that Tax is able to stably bind to both Sp1 and NGFI-A/Egr-1.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	co-immunoprecipitation	co-immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	stably	stably	ADV	RB	_	_	_	_	_
12	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9470
# text = Interestingly, co-immunoprecipitation analysis also revealed that Tax mutant IEXC29S is unable to interact with NGFI-A/Egr-1, whereas Tax mutant IEXL320G is able to interact with NGFI-A/Egr-1.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	co-immunoprecipitation	co-immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
9	mutant	mutant	PROPN	NNP	Number=Sing	_	_	_	_
10	IEXC29	IEXC29	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	S	S	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
27	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
28	IEXL320G	Iexl320g	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	NGFI	NGFI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9471
# text = Document 0030011848 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011848	0030011848	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9472
# text = An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9473
# text = Lymphocytes are particularly susceptible to DNA damage-induced apoptosis, a response which may serve as a form of 'altruistic suicide' to counter their intrinsic high potential for mutation and clonal expansion.
1	Lymphocytes	Lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	particularly	particularly	ADV	RB	_	_	_	_	_
4	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
7	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	form	form	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	'altruistic	'altruistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	suicide	suicide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	'	'	PUNCT	''	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	counter	counter	VERB	VB	VerbForm=Inf	_	_	_	_
26	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
28	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
29	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
34	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9474
# text = The tumour suppressor p53 has been shown to regulate this type of apoptosis in thymocytes, but an as yet unknown, p53-independent pathway(s) appears to mediate the same event in mitogen-activated mature T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
3	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
4	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	yet	yet	ADV	RB	_	_	_	_	_
21	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-independent	-independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	s	s	X	AFX	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
34	event	event	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9475
# text = Here we show DNA damage-induced apoptosis in these T lymphocytes is dependent on the antioncogenic transcription factor interferon regulatory factor (IRF)-1.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	antioncogenic	antioncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	interferon	interferon	ADP	IN	_	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9476
# text = Thus two different anti-onco-genic transcription factors, p53 and IRF-1, are required for distinct apoptotic pathways in T lymphocytes.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
4	anti-onco	anti-onco	X	AFX	_	_	_	_	SpaceAfter=No
5	-genic	-genic	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p53	p53	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
19	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
20	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9477
# text = We also show that mitogen induction of the interleukin-1 beta converting enzyme (ICE) gene, a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3, is IRF-1-dependent.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	converting	converte	VERB	VBG	VerbForm=Ger	_	_	_	_
14	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	ICE	ice	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
22	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Caenorhabditis	Caenorhabditis	PROPN	NNP	Number=Sing	_	_	_	_
26	elegans	elegans	PROPN	NNPS	Number=Plur	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	death	death	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	ced	ce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
31	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9478
# text = Ectopic overexpression of IRF-1 results in the activation of the endogenous gene for ICE and enhances the sensitivity of cells to radiation-induced apoptosis.
1	Ectopic	Ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	ICE	ice	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9479
# text = Document 0030011851 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011851	0030011851	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9480
# text = Effects of CD45 on NF-kappa B.
1	Effects	Effects	PROPN	NNPS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9481
# text = Implications for replication of HIV-1.
1	Implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9482
# text = Increased levels of replication of the HIV type 1 are observed after the activation of infected T cells through the TCR.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9483
# text = However, anti-CD45 antibodies inhibit these effects in cells from infected individuals.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	anti-CD45	anti-CD45	NUM	CD	NumType=Card	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9484
# text = In this study, we examined interrelationships between CD45 and HIV-1 further.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	interrelationships	interrelationship	NOUN	NNS	Number=Plur	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	further	further	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9485
# text = We measured effects on the HIV-1 LTR in T cell lines that were stimulated with antibodies against CD45 and in those that lacked the expression of CD45 on their surfaces.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
19	against	against	ADP	IN	_	_	_	_	_
20	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9486
# text = First, anti-CD45 antibodies did not affect basal but decreased activated levels of expression from the HIV-1 LTR.
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	anti-CD45	anti-CD45	NUM	CD	NumType=Card	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
8	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	LTR.	LTR.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9487
# text = Second, T cells, which lack CD45 and cannot signal via the TCR, supported higher levels of viral replication and gene expression.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	CD45	Cd45	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
11	not	not	PART	RB	_	_	_	_	_
12	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	supported	support	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9488
# text = This was due to the presence of active NF-kappa B complexes in the nucleus of CD45- T cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9489
# text = Additionally, infected T cells displayed lower levels of CD45 on their surfaces.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9490
# text = Thus, CD45 plays an active role in the physiology of T cells and in the replication of HIV-1.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	physiology	physiology	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9491
# text = Document 0030011855 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011855	0030011855	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9492
# text = Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.
1	Astrocytes	Astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	glioblastoma	glioblastoma	NOUN	NN	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9493
# text = The 'octamer' sequence, ATGCAAAT or its complement ATTTGCAT, is a key element for the transcriptional regulation of immunoglobulin genes in B-lymphocytes as well as a number of housekeeping genes in all cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
3	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	'	'	PUNCT	''	_	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	ATGCAAAT	Atgcaaat	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
11	ATTTGCAT	Atttgcat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	as	as	ADV	RB	_	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	number	number	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	housekeeping	housekeeping	NOUN	NN	Number=Sing	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	all	all	DET	DT	_	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9494
# text = In lymphocytes, the octamer-binding protein Oct-2A and variants thereof are thought to contribute to the B-cell specific gene expression, while the ubiquitous protein Oct-1 seems to control general octamer site-dependent transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	octamer-binding	octamer-binding	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	Oct-2	Oct-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
11	thereof	thereof	CCONJ	CC	Typo=Yes	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	while	while	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
35	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
36	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9495
# text = Various other genes, for example interleukin-1 and MHC class II genes, contain an octamer sequence in the promoter and are expressed in cells of both the immune and nervous systems.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	example	example	NOUN	NN	Number=Sing	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	both	both	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
34	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9496
# text = This prompted us to analyze the octamer-binding proteins in the latter cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	prompted	prompt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9497
# text = Using the electrophoretic mobility shift assay, at least six novel octamer binding proteins were detected in nuclear extracts of cultured mouse astrocytes.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	at	at	ADV	RB	_	_	_	_	_
9	least	least	ADV	RBS	Degree=Sup	_	_	_	_
10	six	six	NUM	CD	NumType=Card	_	_	_	_
11	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
12	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
23	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9498
# text = These proteins are differentially expressed in human glioblastoma and neuroblastoma cell lines.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	differentially	differentially	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	glioblastoma	glioblastoma	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9499
# text = The nervous system-derived (N-Oct) proteins bound to the octamer DNA sequence in a manner which is indistinguishable from the Oct-1 and Oct-2A proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-1	-1	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9500
# text = The relationship of the N-Oct proteins to Oct-1 and Oct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against recombinant Oct-1 and Oct-2A proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Oct-2A	Oct-2A	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	clipping	clipping	NOUN	NN	Number=Sing	_	_	_	_
20	bandshift	bandshift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
26	towards	towards	ADP	IN	_	_	_	_	_
27	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	_
28	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	against	against	ADP	IN	_	_	_	_	_
30	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
31	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-1	-1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9501
# text = On the basis of these assays, all N-Oct-factors were found to be distinct from the ubiquitous Oct-1 and the lymphoid-specific Oct-2A proteins.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
22	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	A	a	NOUN	NN	Number=Sing	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9502
# text = In melanoma cells that contain the N-Oct-3 factor, a transfected lymphocyte-specific promoter was neither activated nor was it repressed upon contransfection with an Oct-2A expression vector.
1	In	in	ADP	IN	_	_	_	_	_
2	melanoma	melanoma	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	neither	neither	ADV	RB	_	_	_	_	_
21	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	nor	nor	CCONJ	CC	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	upon	upon	ADP	IN	_	_	_	_	_
27	contransfection	contransfection	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9503
# text = We therefore speculate that N-Oct-3 and other N-Oct factors have a specific role in gene expression in cells of the nervous system.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9504
# text = Document 0030011857 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011857	0030011857	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9505
# text = CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
19	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9506
# text = CD40 is an important signaling and activation
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9507
# text = Ag found on certain bone marrow-derived cells.
1	Ag	ag	PROPN	NNP	Number=Sing	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
5	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
6	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9508
# text = Recently, CD40 also has been shown to be expressed by mesenchymal cells, including human fibroblasts.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	mesenchymal	mesenchymal	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9509
# text = Little is known about the role of CD40 in fibroblasts.
1	Little	little	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	about	about	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9510
# text = The current study investigates the hypothesis that CD40 expressed on lung fibroblasts is an activation structure and mechanism for interaction with hemopoietic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	investigates	investigate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9511
# text = Communication between resident tissue fibroblasts and T cells is necessary for normal wound healing, and can be pathologic, resulting in tissue fibrosis.
1	Communication	communication	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	resident	resident	ADJ	JJ	Degree=Pos	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	T	t	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	wound	wound	NOUN	NN	Number=Sing	_	_	_	_
14	healing	healing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	pathologic	pathologic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
24	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9512
# text = Signaling through CD40 with soluble CD40 ligand stimulated fibroblast activation, as evidenced by mobilization of nuclear factor-kappaB and by induction of the proinflammatory and chemoattractant cytokines IL-6 and IL-8. IFN-gamma-primed lung fibroblasts costimulate T lymphocyte proliferation utilizing CD40, but not the well-studied costimulatory molecules B7-1 and B7-2.
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
7	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor-kappaB	factor-kappab	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	chemoattractant	chemoattractant	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	6	6	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_
36	IFN-gamma	IFN-gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
40	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
41	costimulate	costimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
42	T	t	NUM	CD	NumType=Card	_	_	_	_
43	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
44	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
45	utilizing	utilize	VERB	VBG	VerbForm=Ger	_	_	_	_
46	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	but	but	CCONJ	CC	_	_	_	_	_
49	not	not	ADV	RB	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
55	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
56	B	benefit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
57	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1	1	NUM	CD	NumType=Card	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	B7	B7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
63	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9513
# text = Data reported herein support the hypothesis that cognate interactions between tissue fibroblasts and infiltrating T lymphocytes, via the CD40/CD40L pathway, augment inflammation and may promote fibrogenesis by activating both cell types.
1	Data	data	PROPN	NNP	Number=Sing	_	_	_	_
2	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	herein	herein	ADV	RB	_	_	_	_	_
4	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	cognate	cognate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	infiltrating	infiltrat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CD40/CD40L	Cd40/cd40l	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	augment	augment	NOUN	NN	Number=Sing	_	_	_	_
24	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
28	fibrogenesis	fibrogenesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9514
# text = Document 0030011858 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011858	0030011858	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9515
# text = A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	DPA	DPA	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	member	member	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	subfamily	subfamily	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
21	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
27	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
28	control	control	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9516
# text = A novel DNA sequence element termed the J element involved in the regulated expression of class II major histocompatibility complex genes was recently described.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	termed	term	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	J	j	PROPN	NNP	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	class	class	NOUN	NN	Number=Sing	_	_	_	_
17	II	ii	NUM	CD	NumType=Card	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	recently	recently	ADV	RB	_	_	_	_	_
24	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9517
# text = To study this element and its role in class II gene regulation further, a cDNA library was screened with oligonucleotide probes containing both the S element and the nearby J element of the human DPA gene.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
7	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	further	further	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
18	library	library	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	screened	screen	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
23	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
24	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	S	s	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nearby	nearby	ADJ	JJ	Degree=Pos	_	_	_	_
32	J	j	NOUN	NN	Number=Sing	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	DPA	DPA	PROPN	NNP	Number=Sing	_	_	_	_
38	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9518
# text = Several DNA clones were obtained by this procedure, one of which, clone 18, is reported and characterized here.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	one	one	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Int	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
15	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9519
# text = It encodes a protein predicted to contain 688 amino acid residues, including 11 zinc finger motifs of the C2H2 type in the C-terminal region, that are Kruppel-like in the conservation of the H/C link sequence connecting them.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
8	688	688	NUM	CD	NumType=Card	_	_	_	_
9	amino	amino	DET	DT	_	_	_	_	_
10	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
11	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	11	11	NUM	CD	NumType=Card	_	_	_	_
15	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
16	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	C2H2	C2h2	NOUN	NN	Number=Sing	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	like	like	ADP	IN	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	conservation	conservation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	H/	h/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	C	c	NOUN	NN	Number=Sing	_	_	_	_
40	link	link	NOUN	NN	Number=Sing	_	_	_	_
41	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
42	connecting	connect	VERB	VBG	VerbForm=Ger	_	_	_	_
43	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9520
# text = The 160 N-terminal amino acids in the nonfinger region of clone 18 are highly homologous with similar regions of several other human, mouse, and Drosophila sequences, defining a subfamily of Kruppel-like zinc finger proteins termed TAB (tramtrack [ttk]-associated box) here.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	160	160	NUM	CD	NumType=Card	_	_	_	_
3	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	amino	amino	DET	DT	_	_	_	_	_
6	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nonfinger	nonfinger	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
13	18	18	NUM	CD	NumType=Card	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	highly	highly	ADV	RB	_	_	_	_	_
16	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
19	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	human	human	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
29	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	defining	define	VERB	VBG	VerbForm=Ger	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	subfamily	subfamily	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
38	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
39	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
41	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	TAB	Tab	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	tramtrack	tramtrack	NOUN	NN	Number=Sing	_	_	_	_
45	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	ttk	ttk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9521
# text = One of the Drosophila sequences, ttk, is a developmental control gene, while a second does not contain a zinc finger region but encodes a structure important in oocyte development.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	ttk	ttk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
23	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
29	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	oocyte	oocyte	ADJ	JJ	Degree=Pos	_	_	_	_
32	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9522
# text = An acidic activation domain is located between the N-terminal conserved region of clone 18 and its zinc fingers.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
15	18	18	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
19	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9523
# text = This protein appears to require both the S and J elements, which are separated by 10 bp for optimal binding.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	S	s	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	J	j	NOUN	NN	Number=Sing	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	10	10	NUM	CD	NumType=Card	_	_	_	_
18	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
21	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9524
# text = Antisense cDNA to clone 18 inhibited the expression of a reporter construct containing the DPA promoter, indicating its functional importance in the expression of this class II gene.
1	Antisense	Antisense	ADJ	JJ	Degree=Pos	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	clone	clone	VERB	VB	VerbForm=Inf	_	_	_	_
5	18	18	NUM	CD	NumType=Card	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	DPA	DPA	PROPN	NNP	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	class	class	NOUN	NN	Number=Sing	_	_	_	_
28	II	ii	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9525
# text = Document 0030011859 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011859	0030011859	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9526
# text = Alpha 4 beta 1 (CD49d/CD29) integrin costimulation of human T cells enhances transcription factor and cytokine induction in the absence of altered sensitivity to anti-CD3 stimulation.
1	Alpha	Alpha	PROPN	NNP	Number=Sing	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	CD49d/CD29	Cd49d/cd29	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
9	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9527
# text = The integrin alpha 4 beta 1 can provide a costimulus to induce IL-2 secretion and IL-2R expression leading to enhanced proliferation of purified, peripheral blood T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	ADP	IN	_	_	_	_	_
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	costimulus	costimulus	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9528
# text = Similar to expression of IL-2, we demonstrated that recombinant vascular-cell adhesion molecule-1, when co-immobilized with anti-CD3 mAb, significantly enhanced the induction of transcription factors NF-AT, AP-1, and NF-kappa
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	expression	expression	VERB	VB	VerbForm=Inf	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
13	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	co-immobilized	co-immobilized	ADJ	JJ	Degree=Pos	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
24	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	significantly	significantly	ADV	RB	_	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 9529
# text = B as determined by electromobility shift assays.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	as	as	SCONJ	IN	_	_	_	_	_
3	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	electromobility	electromobility	NOUN	NN	Number=Sing	_	_	_	_
6	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
7	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9530
# text = alpha 4 beta 1 ligation alone had no effect on transcription factor binding.
1	alpha	alpha	ADP	IN	_	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
6	alone	alone	ADV	RB	_	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9531
# text = The requirements for induction of transcription factors reflected the requirements for the secretion of multiple cytokines, including IL-2, TNF-alpha, IFN-gamma, and granulocyte macrophage-CSF.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	reflected	reflect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
33	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9532
# text = In contrast to freshly isolated T cells, in vitro-cultured T cells did not require costimulation for cytokine secretion in response to anti-CD3 alone.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	freshly	freshly	ADV	RB	_	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
18	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
21	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
26	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9533
# text = Comparison of the dose response to anti-CD3 stimulation demonstrated that half-maximal induction of IL-2 was achieved using the same dose of anti-CD3 for both freshly isolated and cultured T cells.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	dose	dose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
24	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	both	both	CCONJ	CC	_	_	_	_	_
29	freshly	freshly	ADV	RB	_	_	_	_	_
30	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9534
# text = Furthermore, the dose of OKT3 required to achieve half-maximal activation was the same using PMA or different concentrations of alpha 4 beta 1 ligands.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	achieve	achieve	VERB	VB	VerbForm=Inf	_	_	_	_
10	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	using	using	VERB	VBG	VerbForm=Ger	_	_	_	_
18	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9535
# text = Therefore, costimulation by alpha 4 beta 1 ligands was not due to stabilization of the interaction of the cells with its substrate.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	alpha	alpha	ADV	RB	_	_	_	_	_
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	due	due	ADP	IN	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9536
# text = We conclude, rather, that alpha 4 beta 1 in freshly isolated T cells delivers a distinct signal that synergizes early with signals initiated by TCR/CD3 ligation to induce DNA binding of multiple transcription factors required for cytokine gene induction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	rather	rather	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	alpha	alpha	ADP	IN	_	_	_	_	_
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	freshly	freshly	ADV	RB	_	_	_	_	_
13	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	delivers	deliver	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	synergizes	synergize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	early	early	ADV	RB	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
25	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	TCR/	TCR/	SYM	SYM	_	_	_	_	SpaceAfter=No
28	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
29	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
38	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9537
# text = Document 0030011865 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011865	0030011865	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9538
# text = Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	amyloid	amyloid	ADJ	JJ	Degree=Pos	_	_	_	_
12	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
19	microglia	microglia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9539
# text = An increasing body of evidence suggests that amyloid-beta (A beta) peptides and microglia are crucially involved in the pathogenesis of Alzheimer's disease.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
3	body	body	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	amyloid	amyloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	microglia	microglion	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	crucially	crucially	ADV	RB	_	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Alzheimer	Alzheimer	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	's	's	PART	POS	_	_	_	_	_
27	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9540
# text = In an effort to further elucidate the biological effects of A beta towards microglia, we investigated the ability of A beta peptides to activate nuclear factor (NF)-kappa B in the N9 murine microglial cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	effort	effort	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	further	further	ADV	RB	_	_	_	_	_
6	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	towards	towards	ADP	IN	_	_	_	_	_
14	microglia	microglion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
23	peptides	peptide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	N9	N9	PROPN	NNP	Number=Sing	_	_	_	_
37	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
38	microglial	microglial	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9541
# text = Co-stimulation of microglia with suboptimal concentrations of A beta(25-35) and 100 U/ml IFN gamma resulted in the detection of a specific NF-kappa B DNA-binding activity in nuclear extracts, as determined in gel mobility shift assays.
1	Co-stimulation	Co-stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	microglia	microglia	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	suboptimal	suboptimal	ADJ	JJ	Degree=Pos	_	_	_	_
6	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-35	-35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	100	100	NUM	CD	NumType=Card	_	_	_	_
16	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
18	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
19	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
20	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	as	as	SCONJ	IN	_	_	_	_	_
40	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
43	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
44	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
45	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9542
# text = This response required at least 120 min to be evident and supershift experiments revealed that the NF-kappa B complex contains both RelA and p50.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADV	RB	_	_	_	_	_
5	least	least	ADV	RBS	Degree=Sup	_	_	_	_
6	120	120	NUM	CD	NumType=Card	_	_	_	_
7	min	min	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
13	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
14	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
22	contains	contain	NOUN	NNS	Number=Plur	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9543
# text = Accordingly, immunoblot experiments showed that amongst NF-kappa B/Rel proteins, RelA and p50 are mobilized to the nucleus following microglial cell stimulation with A beta(25-35) plus IFN gamma.
1	Accordingly	accordingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	amongst	amongst	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	RelA	Rela	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p50	p50	NUM	CD	NumType=Card	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	mobilized	mobilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
24	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
25	microglial	microglial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	plus	plus	CCONJ	CC	_	_	_	_	_
37	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
38	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9544
# text = Higher concentrations of A beta(25-35) were effective by themselves in inducing NF-kappa B activation, both in the N9 microglial cell line and in rat primary microglia, as well as in human monocytes.
1	Higher	Higher	DET	DT	_	_	_	_	_
2	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	35	35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	themselves	themselves	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	N9	N9	PROPN	NNP	Number=Sing	_	_	_	_
27	microglial	microglial	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
33	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
34	microglia	microglia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	as	as	ADV	RB	_	_	_	_	_
37	well	well	ADV	RB	Degree=Pos	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9545
# text = For purposes of comparison, microglia were also stimulated with bacterial LPS, a known NF-kappa B inducer.
1	For	for	ADP	IN	_	_	_	_	_
2	purposes	purpose	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	microglia	microglia	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9546
# text = As expected, LPS strongly induced the formation of two NF-kappa B DNA-binding activities, one of which was identified as RelA/p50.
1	As	as	ADP	IN	_	_	_	_	_
2	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
5	strongly	strongly	ADV	RB	_	_	_	_	_
6	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9547
# text = The LPS response was also more rapid, as it was already evident by 40 min and remained sustained for up to 3 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	more	more	ADV	RBR	_	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	already	already	ADV	RB	_	_	_	_	_
13	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	40	40	NUM	CD	NumType=Card	_	_	_	_
16	min	min	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	up	up	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9548
# text = Collectively, these findings indicate that NF-kappa B activation might constitute one of the mechanisms underlying the inducible expression of kappa B-dependent genes in microglia stimulated by A beta peptides and IFN gamma, or by LPS.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
18	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	microglia	microglion	NOUN	NNS	Number=Plur	_	_	_	_
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
37	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9549
# text = Document 0030011866 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011866	0030011866	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9550
# text = Multiple prolactin-responsive elements mediate G1 and S phase expression of the interferon regulatory factor-1 gene.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	prolactin-responsive	prolactin-responsive	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	G1	G1	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	S	s	PROPN	NNP	Number=Sing	_	_	_	_
8	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9551
# text = The interferon regulatory factor-1 (IRF-1) gene is both an immediate-early G1 phase gene and an S phase gene inducible by PRL in rat Nb2 T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
18	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
19	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	S	S	ADJ	JJ	Degree=Pos	_	_	_	_
24	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	PRL	pRl	PROPN	NNP	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
31	Nb2	Nb2	NUM	CD	NumType=Card	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9552
# text = To understand the mechanism by which PRL regulates the biphasic expression of IRF-1, we cloned the rat IRF-1 gene and functionally characterized the IRF-1 promoter.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	PRL	PRL	PROPN	NNP	Number=Sing	_	_	_	_
8	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	cloned	clon	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
21	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	functionally	functionally	ADV	RB	_	_	_	_	_
27	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9553
# text = Upon transfection into Nb2 T cells, 1.7 kilobases (kb) of IRF-1 5'-flanking DNA linked to a chloramphenicol acetyl transferase (CAT) reporter gene mediated a 30-fold induction of CAT enzyme activity in response to 24 h of PRL stimulation.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	into	into	ADP	IN	_	_	_	_	_
4	Nb2	Nb2	NUM	CD	NumType=Card	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	1.7	1.7	NUM	CD	NumType=Card	_	_	_	_
9	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
26	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
27	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
38	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
41	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	response	response	NOUN	NN	Number=Sing	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	24	24	NUM	CD	NumType=Card	_	_	_	_
47	h	h	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	PRL	Prl	NOUN	NN	Number=Sing	_	_	_	_
50	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9554
# text = Deletion mutants containing 1.3, 0.6, and 0.2 kb
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
3	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
4	1.3	1.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	0.6	0.6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
10	kb	kb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9555
# text = 5'-flanking DNA were incrementally less transcriptionally active, although 0.2 kb still mediated a 12-fold induction by PRL.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	flanking	flanking	NOUN	NN	Number=Sing	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	incrementally	incrementally	ADV	RB	_	_	_	_	_
8	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
9	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
10	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	although	although	SCONJ	IN	_	_	_	_	_
13	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
14	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
15	still	still	ADV	RB	_	_	_	_	_
16	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	PRL	PRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9556
# text = The sequence between -1.7 and -0.2 kb linked to a heterologous thymidine kinase promoter failed to respond to PRL stimulation, suggesting that the activity of upstream PRL response elements may require an interaction with promoter-proximal elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	1.7	1.7	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
9	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
10	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	PRL	PRL	NOUN	NN	Number=Sing	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
30	PRL	PRL	NOUN	NN	Number=Sing	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	_
32	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
41	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9557
# text = By assaying CAT enzyme activity across a 24-h PRL induction time course, we were able to assign G1 vs.
1	By	by	SCONJ	IN	_	_	_	_	_
2	assaying	assay	VERB	VBG	VerbForm=Ger	_	_	_	_
3	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
4	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	across	across	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	h	h	NOUN	NN	Number=Sing	_	_	_	_
11	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	time	time	NOUN	NN	Number=Sing	_	_	_	_
14	course	course	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	assign	assign	VERB	VB	VerbForm=Inf	_	_	_	_
21	G1	G1	NUM	CD	NumType=Card	_	_	_	_
22	vs	v	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9558
# text = S phase PRL responses of the IRF-1 gene to different regions of the IRF-1 5'-flanking and promoter DNA.
1	S	be	NOUN	NN	Number=Sing	_	_	_	_
2	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
3	PRL	Prl	NOUN	NN	Number=Sing	_	_	_	_
4	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9559
# text = The 0.2-kb IRF-CAT construct was induced by PRL stimulation during the G1 phase of the cell cycle.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	0.2	0.2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
5	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
8	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	PRL	Prl	NOUN	NN	Number=Sing	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	G1	G1	PROPN	NNP	Number=Sing	_	_	_	_
17	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9560
# text = In contrast, the 1.7-kb IRF-CAT construct was inducible by PRL during both G1 and S phase of the cell cycle.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	1.7	1.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
8	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
11	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	PRL	pRl	PROPN	NNP	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	G1	G1	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	S	S	PROPN	NNP	Number=Sing	_	_	_	_
21	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9561
# text = Hence, the PRL-induced biphasic expression of the IRF-1 gene appears to be controlled by separate PRL-responsive elements: elements in the first 0.2 kb of the IRF-1 promoter region act during early activation, and elements between 0.2 and 1.7 kb act in concert with the proximal 0.2-kb region during S phase progression.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	PRL	pRl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
21	PRL	Prl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	:	:	PUNCT	:	_	_	_	_	_
26	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
30	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
31	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	region	region	NOUN	NN	Number=Sing	_	_	_	_
39	act	act	NOUN	NN	Number=Sing	_	_	_	_
40	during	during	ADP	IN	_	_	_	_	_
41	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
46	between	between	ADP	IN	_	_	_	_	_
47	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	1.7	1.7	NUM	CD	NumType=Card	_	_	_	_
50	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
51	act	act	NOUN	NN	Number=Sing	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
54	with	with	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
57	0.2	0.2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
60	region	region	NOUN	NN	Number=Sing	_	_	_	_
61	during	during	ADP	IN	_	_	_	_	_
62	S	s	NOUN	NN	Number=Sing	_	_	_	_
63	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
64	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9562
# text = Document 0030011874 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011874	0030011874	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9563
# text = Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules.
1	Peripheral	Peripheral	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
8	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
9	exhibit	exhibit	NOUN	NN	Number=Sing	_	_	_	_
10	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9564
# text = We examined signaling molecules of peripheral blood T lymphocytes obtained from women with breast cancer.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
7	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
15	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9565
# text = In 6 of 14 patients, T lymphocytes displayed an impaired ability to translocate NFeB p65 (Rel-A) following activation by anti-CD3 and IL-2.
1	In	in	ADP	IN	_	_	_	_	_
2	6	6	NUM	CD	NumType=Card	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	14	14	NUM	CD	NumType=Card	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	translocate	translocate	VERB	VB	VerbForm=Inf	_	_	_	_
15	NFeB	NFeB	PROPN	NNP	Number=Sing	_	_	_	_
16	p65	p65	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9566
# text = This observation was made despite normal cytoplasmic levels of the Rel-A protein.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	made	make	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	despite	despite	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9567
# text = We also detected abnormally low levels of the signaling molecules T-cell receptor (TCR)-zeta, ZAP-70 and p56lck in 4 of 14 breast cancer patients, i.e., defects in T-cell signaling molecules.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	abnormally	abnormally	ADV	RB	_	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
10	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
11	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	ZAP	ZAP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	70	70	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	p56lck	p56lck	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	4	4	NUM	CD	NumType=Card	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	14	14	NUM	CD	NumType=Card	_	_	_	_
29	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
30	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
31	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
40	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9568
# text = T lymphocytes from 6 of the 14 patients also exhibited an increased expression of the dual specificity phosphatase, map kinase phosphatase-1 (MKP-1).
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	6	6	NUM	CD	NumType=Card	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	14	14	NUM	CD	NumType=Card	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
17	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
18	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	map	map	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MKP	Mkp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9569
# text = MKP-1 inactivates MAP kinase and therefore may interfere with the activation of c-jun and c-fos.
1	MKP	Mkp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	inactivates	inactivate	NOUN	NNS	Number=Plur	_	_	_	_
5	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	therefore	therefore	ADV	RB	_	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9570
# text = Abnormalities of I or more signaling molecules were found in 9 of 14 patients; however, only 3 patients had T cells that exhibited all 5 defects.
1	Abnormalities	Abnormality	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	9	9	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	14	14	NUM	CD	NumType=Card	_	_	_	_
14	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	only	only	ADV	RB	_	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
21	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	all	all	DET	DT	_	_	_	_	_
27	5	5	NUM	CD	NumType=Card	_	_	_	_
28	defects	defects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9571
# text = Our data have implications for the detection of potentially dysfunctional T cells in patients with cancer.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	potentially	potentially	ADV	RB	_	_	_	_	_
10	dysfunctional	dysfunctional	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9572
# text = For example, the analysis of only 1 signaling molecule may allow patients with significant defects in T-cell signaling to go unnoticed.
1	For	for	ADP	IN	_	_	_	_	_
2	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
16	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	go	go	VERB	VB	VerbForm=Inf	_	_	_	_
23	unnoticed	unnoticed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9573
# text = Finally, despite impaired Rel-A translocation, T cells were capable of transcribing IL-2.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	despite	despite	ADP	IN	_	_	_	_	_
4	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	A	a	NOUN	NN	Number=Sing	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	SCONJ	IN	_	_	_	_	_
15	transcribing	transcribing	VERB	VBG	VerbForm=Ger	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9574
# text = Impairments in the translocation of Rel-B and c-Rel further suggest that the NFKB family members Rel-A, Rel-B and c-Rel are not required for the transcription of IL-2 in the peripheral T lymphocytes of patients with breast cancer.
1	Impairments	Impairment	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
13	further	further	ADV	RB	_	_	_	_	_
14	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NFKB	Nfkb	ADJ	JJ	Degree=Pos	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	_
20	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-A	-A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-B	-B	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
41	T	t	PROPN	NNP	Number=Sing	_	_	_	_
42	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
47	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9575
# text = Document 0030011876 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011876	0030011876	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9576
# text = Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells.
1	Potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	alkaloid	alkaloid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	cepharanthine	cepharanthine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	chronically	chronically	ADV	RB	_	_	_	_	_
17	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9577
# text = Cepharanthine is a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata and has been shown to have antiinflammatory, antiallergic, and immunomodulatory activities in vivo.
1	Cepharanthine	Cepharanthine	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	biscoclaurine	biscoclaurine	NOUN	NN	Number=Sing	_	_	_	_
5	alkaloid	alkaloid	NOUN	NN	Number=Sing	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	Stephania	Stephania	PROPN	NNP	Number=Sing	_	_	_	_
9	cepharantha	cepharantha	PROPN	NNP	Number=Sing	_	_	_	_
10	Hayata	Hayata	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
17	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	antiallergic	antiallergic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9578
# text = As several inflammatory cytokines and oxidative stresses are involved in the pathogenesis of HIV-1 infection, we investigated the inhibitory effects of cepharanthine on tumor necrosis factor alpha (TNF-alpha)- and phorbol 12-myristate 13-acetate (PMA)-induced HIV-1 replication in chronically infected cell lines.
1	As	as	ADP	IN	_	_	_	_	_
2	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
3	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
7	stresses	stress	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cepharanthine	cepharanthine	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
28	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	-	-	PUNCT	:	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
39	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
42	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
44	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	1	1	NUM	CD	NumType=Card	_	_	_	_
53	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	chronically	chronically	ADV	RB	_	_	_	_	_
56	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
58	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9579
# text = Two chronically HIV-1-infected cell lines, U1 (monocytic) and ACH-2 (T lymphocytic), were stimulated with TNF-alpha or PMA and cultured in the presence of various concentrations of the compound.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	chronically	chronically	NOUN	NN	Number=Sing	_	_	_	_
3	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	T	t	NOUN	NN	Number=Sing	_	_	_	_
21	lymphocytic	lymphocytic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
39	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	compound	compound	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9580
# text = HIV-1 replication was determined by p24 antigen level.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	p24	p24	NUM	CD	NumType=Card	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
10	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9581
# text = The inhibitory effects of cepharanthine on HIV-1 long terminal repeat (LTR)-driven gene expression and nuclear factor kappaB (NF-kappaB) activation were also examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cepharanthine	cepharanthine	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	also	also	ADV	RB	_	_	_	_	_
32	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9582
# text = Cepharanthine dose dependently inhibited HIV-1 replication in TNF-alpha- and PMA-stimulated U1 cells but not in ACH-2 cells.
1	Cepharanthine	Cepharanthine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	dose	dose	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
3	dependently	dependently	ADV	RB	_	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	U1	u1	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	ACH	ACH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9583
# text = Its 50% effective and cytotoxic concentrations were 0.016 and 2.2 microg/ml in PMA-stimulated U1 cells, respectively.
1	Its	it	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	%	%	SYM	NN	Number=Sing	_	_	_	_
4	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
7	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	0.016	0.016	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	2.2	2.2	NUM	CD	NumType=Card	_	_	_	_
12	microg	microg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	U1	u1	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9584
# text = Cepharanthine was found to suppress HIV-1 LTR-driven gene expression through the inhibition of NF-kappaB activation.
1	Cepharanthine	Cepharanthine	PRON	PRP	_	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
6	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9585
# text = These results indicate that cepharanthine is a highly potent inhibitor of HIV-1 replication in a chronically infected monocytic cell line.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	cepharanthine	cepharanthine	PRON	PRP	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	highly	highly	ADV	RB	_	_	_	_	_
9	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	chronically	chronically	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9586
# text = Since biscoclaurine alkaloids, containing cepharanthine as a major component, are widely used for the treatment of patients with various inflammatory diseases in Japan, cepharanthine should be further pursued for its chemotherapeutic potential in HIV-1-infected patients.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	biscoclaurine	biscoclaurine	NOUN	NN	Number=Sing	_	_	_	_
3	alkaloids	alkaloid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	cepharanthine	cepharanthine	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	widely	widely	ADV	RB	_	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
22	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Japan	Japan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	cepharanthine	cepharanthine	PRON	PRP	_	_	_	_	_
28	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	further	further	ADV	RB	_	_	_	_	_
31	pursued	pursue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	chemotherapeutic	chemotherapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
35	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9587
# text = Document 0030011877 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011877	0030011877	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9588
# text = Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	b	b	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
9	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	ErbB	ErbB	PROPN	NNP	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
17	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9589
# text = Self renewal of normal erythroid progenitors is induced by the receptor tyrosine kinase c-ErbB, whereas other receptors (c-Kit/Epo-R) regulate erythroid differentiation.
1	Self	self	NOUN	NN	Number=Sing	_	_	_	_
2	renewal	renewal	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
6	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	ErbB	ErbB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	Kit	Kit	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9590
# text = To address possible mechanisms that could explain this selective activity of c-ErbB, we analyzed the ability of these receptors to activate the different members of the Stat transcription factor family.
1	To	to	PART	TO	_	_	_	_	_
2	address	address	VERB	VB	VerbForm=Inf	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	ErbB	ErbB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9591
# text = Ligand activation of c-ErbB induced the tyrosine phosphorylation, DNA-binding, and reporter gene transcription of Stat 5b in erythroblasts.
1	Ligand	Ligand	NOUN	NN	Number=Sing	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	ErbB	ErbB	PROPN	NNP	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	b	b	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9592
# text = In contrast, ligand activation of c-Kit was unable to induce any of these effects in the same cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	ligand	ligand	NUM	CD	NumType=Card	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Kit	Kit	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
14	any	any	DET	DT	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9593
# text = Activation of the erythropoietin receptor caused specific DNA-binding of Stat 5b, but failed to induce reporter gene transcription.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9594
# text = These biochemical findings correlate perfectly with the selective ability of c-ErbB to cause sustained self renewal in erythroid progenitors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
4	correlate	correlate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	perfectly	perfectly	ADV	RB	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	ErbB	ErbB	PROPN	NNP	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
15	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	self	self	NOUN	NN	Number=Sing	_	_	_	_
17	renewal	renewal	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9595
# text = Document 0030011879 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011879	0030011879	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9596
# text = Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the simian virus 40 major late promoter [published erratum appears in J Biol Chem 1995 Nov 3;270(44):26721]
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	TR2	Tr2	NUM	CD	NumType=Card	_	_	_	_
5	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	40	40	NUM	CD	NumType=Card	_	_	_	_
19	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
20	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
25	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	J	j	PROPN	NNP	Number=Sing	_	_	_	_
28	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
29	Chem	Chem	PROPN	NNP	Number=Sing	_	_	_	_
30	1995	1995	NUM	CD	NumType=Card	_	_	_	_
31	Nov	Nov	PROPN	NNP	Number=Sing	_	_	_	_
32	3;270	3;270	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	44)	44)	SYM	NFP	_	_	_	_	SpaceAfter=No
35	:26721	:26721	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9597
# text = A DNA response element (TR2RE-SV40) for the TR2 orphan receptor, a member of the steroid-thyroid hormone receptor superfamily, has been identified in the simian virus 40 (SV40) +55 region (nucleotide numbers 368-389, 5'-GTTAAGGTTCGTAGGTCATGGA-3').
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TR2RE	Tr2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TR2	Tr2	NUM	CD	NumType=Card	_	_	_	_
13	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	member	member	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
23	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
33	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
34	40	40	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	SV40	SV40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	+55	+55	NUM	CD	NumType=Card	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
42	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
43	368-389	368-389	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
47	-GTTAAGGTTCGTAGGTCATGGA	-GTTAAGGTTCGTAGGTCATGGa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9598
# text = Electrophoretic mobility shift assay, using in vitro translated TR2 orphan receptor with a molecular mass of 67 kilodaltons, showed a specific binding with high affinity (dissociation constant = 9 nM) for this DNA sequence.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
9	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TR2	TR2	NUM	CD	NumType=Card	_	_	_	_
11	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	67	67	NUM	CD	NumType=Card	_	_	_	_
19	kilodaltons	kilodalton	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
30	constant	constant	NOUN	NN	Number=Sing	_	_	_	_
31	=	=	SYM	SYM	_	_	_	_	_
32	9	9	NUM	CD	NumType=Card	_	_	_	_
33	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
38	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9599
# text = DNA-swap experiments using chloramphenicol acetyl-transferase assay demonstrated that androgen can suppress the transcriptional activities of SV40 early promoter via the interaction between this TR2RE-SV40 and the chimeric receptor AR/TR2/AR with the DNA-binding domain of the TR2 orphan receptor flanked by the N-terminal and androgen-binding domains of the androgen receptor.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	swap	swap	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
6	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
9	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
10	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
20	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
25	between	between	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	TR2RE	Tr2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	SV40	SV40	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	AR/TR2/	AR/TR2/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	AR	be	NOUN	NN	Number=Sing	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	TR2	Tr2	NUM	CD	NumType=Card	_	_	_	_
45	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
46	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
47	flanked	flank	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-binding	-binding	VERB	VBG	VerbForm=Ger	_	_	_	_
55	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
59	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9600
# text = In addition, this TR2RE-SV40 can function as a repressor to suppress the transcriptional activities of both SV40 early and late promoters.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	TR2RE	Tr2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	SV40	SV40	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	SV40	SV40	NOUN	NN	Number=Sing	_	_	_	_
21	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9601
# text = Together, these data suggest the TR2RE-SV40 may represent the first identified natural DNA response element for the TR2 orphan receptor that may function as a repressor for the SV40 gene expression.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TR2RE	Tr2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	SV40	SV40	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	first	first	ADV	RBS	_	_	_	_	_
14	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
15	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TR2	Tr2	NUM	CD	NumType=Card	_	_	_	_
22	orphan	orphan	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9602
# text = Document 0030011880 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011880	0030011880	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9603
# text = T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells.
1	T	t	NOUN	NN	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
4	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9604
# text = The repetitive activation of T cells (priming) enhances the expression of many cytokines, such as IL-4, but not others, such as IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	repetitive	repetitive	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	priming	priming	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9605
# text = Molecular mechanisms underlying selective expression of cytokines by T cells remain poorly understood.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
4	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	poorly	poorly	ADJ	JJ	Degree=Pos	_	_	_	_
13	understood	understand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9606
# text = Here we show that priming of CD4 T cells selectively enhances IL-4 expression relative to IL-2 expression by a transcriptional mechanism involving nuclear factor of activated T cells (NFAT) proteins.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	relative	relative	ADV	RB	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
26	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9607
# text = As detected by in vivo footprinting, priming markedly increases the activation-dependent engagement of the P0 and P1 NFAT-binding elements of the IL-4 promoter.
1	As	as	SCONJ	IN	_	_	_	_	_
2	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
6	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	priming	prim	VERB	VBG	VerbForm=Ger	_	_	_	_
9	markedly	markedly	ADV	RB	_	_	_	_	_
10	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	P0	P0	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	P1	P1	PROPN	NNP	Number=Sing	_	_	_	_
21	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9608
# text = Moreover, each proximal P element is essential for optimal IL-4 promoter activity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	each	each	DET	DT	_	_	_	_	_
4	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
5	P	p	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9609
# text = Activated primed CD4 T cells contain more NFAT1 and support greater NFAT-directed transcription than unprimed CD4 T cells, while activator protein 1 binding and activator protein 1-mediated transcription by both cell types is similar.
1	Activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
8	NFAT1	nfat1	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
12	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
18	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	while	while	SCONJ	IN	_	_	_	_	_
23	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	both	both	DET	DT	_	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	types	type	NOUN	NNS	Number=Plur	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9610
# text = Increased expression of wild-type NFAT1 substantially increases IL-4 promoter activity in unprimed CD4 T cells, suggesting NFAT1 may be limiting for IL-4 gene expression in this cell type.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	NFAT1	nfat1	PROPN	NNP	Number=Sing	_	_	_	_
8	substantially	substantially	ADV	RB	_	_	_	_	_
9	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	unprimed	unprim	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggesting	VERB	VBG	VerbForm=Ger	_	_	_	_
22	NFAT1	nfat1	PROPN	NNP	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	limiting	limit	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9611
# text = Furthermore, a truncated form of NFAT1 acts as a dominant-negative, reducing IL-4 promoter activity in primed CD4 T cells and confirming the importance of endogenous NFAT to increased IL-4 gene expression by effector T cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	form	form	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	_
8	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dominant	dominant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	negative	negative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	confirming	confirm	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
32	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	4	4	NUM	CD	NumType=Card	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9612
# text = NFAT1 appears to be the major NFAT family member responsible for the initial increased expression of IL-4 by primed CD4 T cells.
1	NFAT1	nfat1	NOUN	NN	Number=Sing	_	_	_	_
2	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	member	member	NOUN	NN	Number=Sing	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9613
# text = Document 0030011881 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011881	0030011881	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9614
# text = Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
1	Host	host	ADJ	JJ	Degree=Pos	_	_	_	_
2	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
7	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	toll	toll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9615
# text = The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
8	against	against	ADP	IN	_	_	_	_	_
9	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
10	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	_
12	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-12	-12	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
26	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	innate	innate	ADJ	JJ	Degree=Pos	_	_	_	_
30	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
31	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9616
# text = Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
5	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	12	12	NUM	CD	NumType=Card	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
23	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	so	so	ADV	RB	_	_	_	_	_
25	remain	remain	VERB	VB	VerbForm=Inf	_	_	_	_
26	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9617
# text = Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
7	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimulators	stimulator	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	12	12	NUM	CD	NumType=Card	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	Toll	toll	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	like	like	ADP	IN	_	_	_	_	_
29	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	TLRs	TLRs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9618
# text = Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	TLR	Tlr	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
11	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
12	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
18	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
22	microbicidal	microbicidal	ADJ	JJ	Degree=Pos	_	_	_	_
23	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9619
# text = Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TLRs	TLR	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
6	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
9	innate	innate	ADJ	JJ	Degree=Pos	_	_	_	_
10	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	against	against	ADP	IN	_	_	_	_	_
13	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathogens	pathogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9620
# text = Document 0030011883 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011883	0030011883	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9621
# text = Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	B	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9622
# text = IL-10 and IL-4 suppress cytokine synthesis by different mechanisms.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9623
# text = Our previous studies in human monocytes have demonstrated that interleukin (IL)-10 inhibits lipopolysaccharide (LPS)-stimulated production of inflammatory cytokines, IL-1 beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha by blocking gene transcription.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	10	10	NUM	CD	NumType=Card	_	_	_	_
16	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
43	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
49	alpha	alpha	ADV	RB	_	_	_	_	_
50	by	by	SCONJ	IN	_	_	_	_	_
51	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
52	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
53	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9624
# text = Using electrophoretic mobility shift assays (EMSA), we now show that, in monocytes stimulated with LPS or TNF alpha, IL-10 inhibits nuclear stimulation of nuclear factor kappa B (NF kappa
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	now	now	ADV	RB	_	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9625
# text = B), a transcription factor involved in the expression of inflammatory cytokine genes.
1	B	b	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9626
# text = Several other transcription factors including NF-IL-6, AP-1, AP-2, GR, CREB, Oct-1, and Sp-1 are not affected by IL-10.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Sp	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-1	-1	NUM	CD	NumType=Card	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9627
# text = This selective inhibition by IL-10 of NF kappa B activation occurs rapidly and in a dose-dependent manner and correlates well with IL-10's cytokine synthesis inhibitory activity in terms of both kinetics and dose responsiveness.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
14	rapidly	rapidly	ADV	RB	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	well	well	ADV	RB	Degree=Pos	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	10's	10'	NOUN	NNS	Number=Plur	_	_	_	_
29	cytokine	cytokine	PRON	PRP	_	_	_	_	_
30	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	both	both	DET	DT	_	_	_	_	_
37	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	dose	dose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
40	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9628
# text = Furthermore, compounds such as tosylphenylalanyl chloromethyl ketone and pyrrolidinedithiocarbamate that are known to selectively inhibit NF kappa B activation block cytokine gene transcription in LPS-stimulated monocytes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	tosylphenylalanyl	tosylphenylalanyl	ADJ	JJ	Degree=Pos	_	_	_	_
7	chloromethyl	chloromethyl	NOUN	NN	Number=Sing	_	_	_	_
8	ketone	ketone	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	selectively	selectively	ADV	RB	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	block	block	NOUN	NN	Number=Sing	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9629
# text = Taken together, these results suggest that inhibition of NF kappa B activation may be an important mechanism for IL-10 suppression of cytokine gene transcription in human monocytes.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	10	10	NUM	CD	NumType=Card	_	_	_	_
23	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9630
# text = IL-4, another cytokine that inhibits cytokine mRNA accumulation in monocytes, shows little inhibitory effect on LPS-induced NF kappa B activation.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	another	another	DET	DT	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	cytokine	cytokine	PRON	PRP	_	_	_	_	_
10	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
17	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9631
# text = Further examination reveals that, unlike IL-10, IL-4 enhances mRNA degradation and does not suppress cytokine gene transcription.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	examination	examination	NOUN	NN	Number=Sing	_	_	_	_
3	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	unlike	unlike	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
15	mRNA	mRNa	SYM	SYM	_	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
21	cytokine	cytokine	PRON	PRP	_	_	_	_	_
22	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9632
# text = These data indicate that IL-10 and IL-4 inhibit cytokine production by different mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9633
# text = Document 0030011885 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011885	0030011885	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9634
# text = Activation of lymphokine genes in T cells: role of cis-acting DNA elements that respond to T cell activation signals.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cis-acting	cis-act	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9635
# text = Activation of T cells is initiated by the recognition of antigen on antigen presenting cells to exert the effector functions in immune and inflammatory responses.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
14	presenting	present	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
20	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9636
# text = Two types of helper T cell (Th) clones (Th1 and Th2) are defined on the basis of different patterns of cytokine (lymphokine) secretion.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	types	type	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Th	th	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Th2	th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
23	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9637
# text = They determine the outcome of an antigenic response toward humoral or cell-mediated immunity.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	determine	determine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	outcome	outcome	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	toward	toward	ADP	IN	_	_	_	_	_
10	humoral	humoral	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9638
# text = Although lymphokine genes are coordinately regulated upon antigen stimulation, they are regulated by the mechanisms common to all as well as those which are unique to each gene.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	coordinately	coordinately	ADV	RB	_	_	_	_	_
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	upon	upon	ADP	IN	_	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
17	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	all	all	DET	DT	_	_	_	_	_
20	as	as	ADV	RB	_	_	_	_	_
21	well	well	ADV	RB	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	each	each	DET	DT	_	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9639
# text = For most lymphokine genes, a combination of phorbol esters (phorbol 12-myristate 13 acetate, PMA) and calcium ionophores (A23187) is required for their maximal induction.
1	For	for	ADP	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
10	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
13	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
16	13	13	NUM	CD	NumType=Card	_	_	_	_
17	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
23	ionophores	ionophore	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	A23187	A23187	X	LS	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
32	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9640
# text = Yet phorbol ester alone or calcium ionophore alone produce several lymphokines.
1	Yet	yet	CCONJ	CC	_	_	_	_	_
2	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
3	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
4	alone	alone	ADV	RB	_	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	calcium	calcium	VERB	VB	VerbForm=Inf	_	_	_	_
7	ionophore	ionophore	ADV	RB	_	_	_	_	_
8	alone	alone	ADV	RB	_	_	_	_	_
9	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphokines	lymphokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9641
# text = The production of the granulocyte-macrophage colony stimulating factor (GM-CSF) is completely dependent on the two signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
8	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
9	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	completely	completely	ADV	RB	_	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9642
# text = We have previously found a cis-acting region spanning the GM-CSF promoter region (positions -95 to +27) that confers inducibility to reporter genes in transient transfection assays.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	95	95	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
23	27	27	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	confers	confer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	reporter	reporter	VERB	VB	VerbForm=Inf	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
33	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
34	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9643
# text = Further analysis identified three elements required for efficient induction, referred to as GM2, GC-box and conserved lymphokine element (CLE0).
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	GC	GC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	box	box	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9644
# text = GM2 defines a binding site for protein(s) whose binding is inducible by PMA.
1	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
2	defines	define	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	s	s	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9645
# text = One protein, NF-GM2 is similar to the transcription factor NF-kB.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	GM2	Gm2	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kB.	kB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 9646
# text = GC-box is a binding site for constitutively bound proteins.
1	GC	Gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	box	box	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	constitutively	constitutively	ADV	RB	_	_	_	_	_
10	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9647
# text = CLEO defines a binding site for protein(s) whose optimum binding is stimulated by PMA and A23187.
1	CLEO	Cleo	NOUN	NN	Number=Sing	_	_	_	_
2	defines	define	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	s	s	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
12	optimum	optimum	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
20	23187	23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9648
# text = Viral trans-activators such as Tax (human T cell leukemia virus-1, HTLV-1) and E2 (bovine papilloma virus, BPV) proteins are other agents which activate lymphokine gene expression by bypassing T cell receptor (TCR) mediated signaling.
1	Viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
2	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	E2	E2	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
24	papilloma	papilloma	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	BPV	BPV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
32	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	lymphokine	lymphokine	PRON	PRP	_	_	_	_	_
36	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	by	by	SCONJ	IN	_	_	_	_	_
39	bypassing	bypass	VERB	VBG	VerbForm=Ger	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9649
# text = The trans-activation domain of E2 and Tax is interchangeable although they have no obvious sequence homology between them.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	E2	E2	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	interchangeable	interchangeable	ADJ	JJ	Degree=Pos	_	_	_	_
12	although	although	SCONJ	IN	_	_	_	_	_
13	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
14	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	obvious	obvious	ADJ	JJ	Degree=Pos	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9650
# text = The viral trans-activators appear to target specific DNA binding protein such as NF-kB and Sp1 to cis-acting DNA site and promote lymphokine gene expression without TCR-mediated stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
6	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
22	-acting	-act	ADJ	JJ	Degree=Pos	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
27	lymphokine	lymphokine	PRON	PRP	_	_	_	_	_
28	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	without	without	ADP	IN	_	_	_	_	_
31	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9651
# text = Document 0030011887 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011887	0030011887	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9652
# text = Cloning of ARE-containing genes by AU-motif-directed display.
1	Cloning	Cloning	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ARE	Are	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	AU-motif	AU-motif	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	display	display	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9653
# text = A procedure suitable for cloning labile mRNAs that contain AU motifs is presented (AU-DD).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	_
3	suitable	suitable	ADJ	JJ	Degree=Pos	_	_	_	_
4	for	for	SCONJ	IN	_	_	_	_	_
5	cloning	clon	VERB	VBG	VerbForm=Ger	_	_	_	_
6	labile	labile	ADJ	JJ	Degree=Pos	_	_	_	_
7	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	AU	Au	PRON	PRP	Case=Acc|Person=2|PronType=Prs	_	_	_	_
11	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	presented	present	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	AU	AU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	DD	DD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9654
# text = These motifs are regulatory sequences within the so-called AU-rich elements (AREs) often found in 3' untranslated regions of genes such as cytokines, proto-oncogenes, and transcription factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	AU-	Au-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	AREs	ARE	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	often	often	ADV	RB	_	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	'	'	PUNCT	``	_	_	_	_	_
22	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
23	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9655
# text = AU-DD is an AU-motif-directed differential display that permits the identification of ARE-containing genes differentially expressed after cell activation.
1	AU	AU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	DD	DD	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	AU-motif	AU-motif	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-directed	-direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
9	display	display	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	permits	permit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	ARE	Are	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	differentially	differentially	ADV	RB	_	_	_	_	_
20	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9656
# text = It has been applied to peripheral blood monocytes and a T cell clone to isolate 59 cDNA fragments associated to activation.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
7	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
8	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
16	59	59	NUM	CD	NumType=Card	_	_	_	_
17	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
18	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9657
# text = Fourteen percent of isolated fragments belong to already known genes that certainly are cytokines and transduction/transcription factors.
1	Fourteen	Fourteen	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	percent	percent	ADJ	JJ	Degree=Pos	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
6	belong	belong	ADP	IN	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	already	already	ADV	RB	_	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	certainly	certainly	ADV	RB	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9658
# text = The remaining 86% correspond to unknown genes of which 92% have been confirmed to be differentially expressed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	remaining	remaining	ADJ	JJ	Degree=Pos	_	_	_	_
3	86	86	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	%	%	SYM	NN	Number=Sing	_	_	_	_
5	correspond	correspond	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	which	which	DET	WDT	PronType=Int	_	_	_	_
11	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	%	%	SYM	NN	Number=Sing	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	differentially	differentially	ADV	RB	_	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9659
# text = These data demonstrate the efficiency of the system and support the notion that numerous genes falling into those categories remain unidentified and that they can be cloned by this method.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	system	system	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	support	support	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	falling	fall	VERB	VBG	VerbForm=Ger	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	categories	category	NOUN	NNS	Number=Plur	_	_	_	_
20	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	method	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9660
# text = Copyright 1998 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1998	1998	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9661
# text = Document 0030011889 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011889	0030011889	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9662
# text = Role of ascorbate in the activation of NF-kappaB by tumour necrosis factor-alpha in T-cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	tumour	tumour	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
13	necrosis	necrosis	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9663
# text = The first product of ascorbate oxidation, the ascorbate free radical (AFR), acts in biological systems mainly as an oxidant, and through its role in the plasma membrane redox system exerts different effects on the cell.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	product	product	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	ascorbate	ascorbate	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxidation	oxidation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
10	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
11	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	AFR	AFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
19	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
20	mainly	mainly	ADV	RB	_	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	oxidant	oxidant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
32	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
33	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
34	system	system	NOUN	NN	Number=Sing	_	_	_	_
35	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
36	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
37	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
38	on	on	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9664
# text = We have investigated the role of ascorbate, AFR and dehydroascorbate (DHA) in the activation of the NF-kappaB transcription factor in Jurkat T-cells stimulated by tumour necrosis factor-alpha (TNF-alpha).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	AFR	Afr	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	dehydroascorbate	dehydroascorbate	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	DHA	DHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
27	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
32	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9665
# text = Here we show, by electrophoretic mobility shift assays, that ascorbate increases the binding of NF-kappaB to DNA in TNF-alpha-stimulated Jurkat cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
7	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
8	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
9	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
13	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	DNA	Dna	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9666
# text = The ability of ascorbate to enhance cytoplasmic inhibitory IkBalpha protein degradation correlates completely with its capacity to induce NF-kappaB binding to DNA and to potentiate NF-kappaB-mediated transactivation of the HIV-1 long terminal repeat promoter in TNF-alpha-stimulated Jurkat cells but not in cells stimulated with PMA plus ionomycin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
7	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
9	IkBalpha	IkBalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	potentiate	potentiate	VERB	VB	VerbForm=Inf	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
40	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
41	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	but	but	CCONJ	CC	_	_	_	_	_
52	not	not	PART	RB	_	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
55	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	with	with	ADP	IN	_	_	_	_	_
57	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
58	plus	plus	CCONJ	CC	_	_	_	_	_
59	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9667
# text = AFR behaves like ascorbate, while DHA and ascorbate phosphate do not affect TNF-alpha-mediated NF-kappaB activation.
1	AFR	Afr	ADJ	JJR	Degree=Cmp	_	_	_	_
2	behaves	behave	NOUN	NNS	Number=Plur	_	_	_	_
3	like	like	ADP	IN	_	_	_	_	_
4	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	while	while	SCONJ	IN	_	_	_	_	_
7	DHA	DHA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	ascorbate	ascorbate	ADJ	JJ	Degree=Pos	_	_	_	_
10	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9668
# text = These results provide new evidence for a possible relationship between the activation of the electron-transport system at the plasma membrane by ascorbate or its free radical and redox-dependent gene transcription in T-cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
9	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	electron	electron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	transport	transport	NOUN	NN	Number=Sing	_	_	_	_
18	system	system	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
22	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
28	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	redox	redox	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9669
# text = Document 0030011891 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011891	0030011891	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9670
# text = Stimulation of interferon beta gene transcription in vitro by purified NF-kappa B and a novel TH protein.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
18	TH	th	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9671
# text = The human interferon beta (IFN-beta) regulatory element consists of multiple enhanson domains which are targets for transcription factors involved in inducible expression of the promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	enhanson	enhanson	NOUN	NN	Number=Sing	_	_	_	_
16	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9672
# text = To further characterize the protein-DNA interactions mediating IFN-beta induction, positive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
9	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PRD	pRd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
28	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
36	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	cycloheximide/polyinosinic	cycloheximide/polyinosinic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	polycytidylic	polycytidylic	ADJ	JJ	Degree=Pos	_	_	_	_
41	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
42	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
44	S3	S3	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9673
# text = From HeLa cells, two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity, whereas from T-cells, four proteins--a major protein of 52 kD and three minor proteins of 82, 67, and 43-47 kD--were purified.
1	From	from	ADP	IN	_	_	_	_	_
2	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	52	52	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	45	45	NUM	CD	NumType=Card	_	_	_	_
12	kilodaltons	kilodalton	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	kD	k	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	copurified	copurify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	wherea	SCONJ	IN	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	four	four	NUM	CD	NumType=Card	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	52	52	NUM	CD	NumType=Card	_	_	_	_
35	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	three	three	NUM	CD	NumType=Card	_	_	_	_
38	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	82	82	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	67	67	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	43	43	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
48	47	47	NUM	CD	NumType=Card	_	_	_	_
49	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
51	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
52	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9674
# text = Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the (AAGTGA)4 tetrahexamer sequence and the PRDI domain.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	AAGTGA	AAGTGA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	tetrahexamer	tetrahexamer	NOUN	NN	Number=Sing	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	PRDI	PRDI	PROPN	NNP	Number=Sing	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9675
# text = This protein is immunologically distinct from IRF-1/ISGF2.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	immunologically	immunologically	ADV	RB	_	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1/ISGF2	1/isgf2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9676
# text = Uninduced or Sendai virus induced HeLa extracts were used to examine transcription in vitro using a series of IFN beta promoter deletions.
1	Uninduced	Uninduce	PROPN	NNP	Number=Sing	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	Sendai	Sendbe	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	series	series	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
20	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9677
# text = Deletions upstream of the PRDII element increased transcription in the uninduced extract, indicating predominantly negative regulation of the promoter.
1	Deletions	Deletion	NOUN	NNS	Number=Plur	_	_	_	_
2	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	PRDII	PRDII	PROPN	NNP	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	uninduced	uninduced	ADJ	JJ	Degree=Pos	_	_	_	_
12	extract	extract	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	predominantly	predominantly	ADV	RB	_	_	_	_	_
16	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9678
# text = A 2-4-fold increase in IFN-beta promoter transcription was observed in Sendai virus induced extracts, and deletion of PRDI and PRDII elements decreased this induced level of transcription.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Sendai	Sendai	PROPN	NNP	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	PRDI	PRDI	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	PRDII	Prdii	PROPN	NNP	Number=Sing	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9679
# text = When purified PRDII and tetrahexamer binding proteins were added to the induced extract, a 4-fold increase in transcription was observed.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PRDII	pRDIi	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	tetrahexamer	tetrahexamer	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	extract	extract	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9680
# text = These experiments demonstrate that it is possible to modulate IFN-beta transcription in vitro but indicate that additional proteins may be required to fully activate IFN-beta transcription.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	fully	fully	ADV	RB	_	_	_	_	_
26	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
27	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9681
# text = Document 0030011893 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011893	0030011893	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9682
# text = Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.
1	Cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	rapidly	rapidly	ADV	RB	_	_	_	_	_
9	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9683
# text = The B cell-associated surface molecule CD40 functions to regulate B cell responses.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	B	B	NOUN	NN	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9684
# text = Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 production, and, in combination with cytokines, to Ig isotype switching.
1	Cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	homotypic	homotypic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	Ig	ig	VERB	VB	VerbForm=Inf	_	_	_	_
29	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
30	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9685
# text = Tyrosine kinase activity is increased shortly after engagement of this receptor.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	shortly	shortly	ADV	RB	_	_	_	_	_
7	after	after	ADP	IN	_	_	_	_	_
8	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9686
# text = Little is known about how the very early events induced by CD40 cross-linking link to cellular responses.
1	Little	little	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	about	about	SCONJ	IN	_	_	_	_	_
5	how	how	ADV	WRB	PronType=Int	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
13	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	linking	link	NOUN	NN	Number=Sing	_	_	_	_
16	link	link	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9687
# text = In this study, we demonstrate that nuclear factor (NF)-kappa B and NF-kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
30	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
31	on	on	SCONJ	IN	_	_	_	_	_
32	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	tonsillar	tonsillar	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	on	on	ADP	IN	_	_	_	_	_
39	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9688
# text = The activation is rapid and is mediated through a tyrosine kinase-dependent pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9689
# text = The complexes detected in electrophoretic mobility shift assays contain p50, p65 (RelA), c-Rel, and most likely other components.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
6	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
7	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
8	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
9	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	p65	p65	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
23	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
24	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9690
# text = By using transient transfection assays, we found that cross-linking CD40 supports NF-kappa B-dependent gene expression.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
4	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
12	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
13	supports	support	NOUN	NNS	Number=Plur	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9691
# text = Our results define the NF-kappa B system as an intermediate event in CD40 signaling and suggest that the CD40 pathway can influence the expression of B cell-associated genes with NF-kappa B consensus sites.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	system	system	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
13	event	event	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
16	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9692
# text = Document 0030011895 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011895	0030011895	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9693
# text = Intranuclear targeted delivery of functional NF-kappaB by 70 kDa heat shock protein.
1	Intranuclear	Intranuclear	PROPN	NNP	Number=Sing	_	_	_	_
2	targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	delivery	delivery	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	70	70	NUM	CD	NumType=Card	_	_	_	_
11	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
12	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
13	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9694
# text = The 70 kDa heat shock protein (Hsp70) is a highly conserved, ubiquitous protein involved in chaperoning proteins to various cellular organelles.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	70	70	NUM	CD	NumType=Card	_	_	_	_
3	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
4	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
5	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Hsp70	Hsp70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	highly	highly	ADV	RB	_	_	_	_	_
13	conserved	conserved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	chaperoning	chaperon	VERB	VBG	VerbForm=Ger	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	organelles	organelle	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9695
# text = Here we show that when added exogenously to cells, Hsp70 is readily imported into both cytoplasmic and nuclear compartments in a cell-type-specific fashion.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	exogenously	exogenously	ADV	RB	_	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Hsp70	Hsp70	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	readily	readily	ADV	RB	_	_	_	_	_
14	imported	import	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	compartments	compartment	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9696
# text = We exploited this ability of Hsp70 to deliver NF-kappaB, a key transcriptional regulator of inflammatory responses.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	exploited	exploit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Hsp70	Hsp70	PROPN	NNP	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	deliver	deliver	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	responses	respons	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9697
# text = We demonstrate that a fusion protein composed of a C-terminal Hsp70 peptide and the p50 subunit of NF-kappaB was directed into the nucleus of cells, could bind DNA specifically, and activated Igkappa expression and TNFalpha production.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
13	Hsp70	Hsp70	NOUN	NN	Number=Sing	_	_	_	_
14	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	into	into	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
32	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	specifically	specifically	ADV	RB	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	Igkappa	Igkappa	PROPN	NNP	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
42	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9698
# text = We therefore propose that Hsp70 can be used as a vehicle for intracytoplasmic and intranuclear delivery of proteins or DNA to modulate gene expression and thereby control immune responses.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Hsp70	Hsp70	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	vehicle	vehicle	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	intranuclear	intranuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	delivery	delivery	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	thereby	thereby	ADV	RB	_	_	_	_	_
27	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
28	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
29	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9699
# text = Document 0030011899 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011899	0030011899	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9700
# text = A negative regulatory region containing a glucocorticosteroid response element (nGRE) in the human interleukin-1beta gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	glucocorticosteroid	glucocorticosteroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	nGRE	nGRE	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	gene.	gene.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 9701
# text = Interleukin-1 beta (IL-1beta) is one of the most important inflammatory mediators in human inflammatory and immunological diseases.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	most	most	ADV	RBS	_	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
24	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9702
# text = The regulation of human IL-1beta gene expression has been studied for several years, and a few regulatory elements have been discovered in the promoter region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
16	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9703
# text = However, little is known about negative regulation of IL-1beta expression at the transcriptional level, which may play an important role in anti-inflammatory and immunosuppressive effects.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	about	about	ADP	IN	_	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
30	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9704
# text = We have identified a negative regulatory element located in the region between -685 and -395.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	-685	-685	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	395	395	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9705
# text = Within this region, a 19-bp nuclear factor binding site (-570 to -552) was characterized by DNase I footprinting and electromobility shift assay.
1	Within	within	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	(-570	(-570	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	552	552	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
23	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	electromobility	electromobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9706
# text = A consensus sequence for a negative glucocorticoid response element (nGRE) and a transcription activator protein-2 binding site were noted within this footprint.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	nGRE	nGRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	within	within	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9707
# text = Functional studies showed a 2.5-fold increase in promoter activity when this 19-bp binding site was deleted in the reporter constructs IL-1beta/CAT and IL-1beta/SV40 promoter/CAT.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	constructs	construct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
40	CAT.	CAT.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 9708
# text = Dexamethasone (10(-8) M) repressed chloramphenicol acetyltransferase (CAT) production by 75% in the wild-type fragment but not in a deletion mutant lacking the 19-bp site.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
5	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	M	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
30	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
31	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9709
# text = A protein of about 150 kD that bound to this negative regulatory sequence was identified by UV cross-linking.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	about	about	ADV	RB	_	_	_	_	_
5	150	150	NUM	CD	NumType=Card	_	_	_	_
6	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	ADV	WRB	PronType=Rel	_	_	_	_
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
18	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-linking	-linking	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9710
# text = This is the first description of a negative regulatory region responsive to glucocorticoids in a cytokine gene.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	description	description	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9711
# text = Document 0030011900 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011900	0030011900	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9712
# text = Differences in transcriptional enhancers of HIV-1 and HIV-2.
1	Differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9713
# text = Response to T cell activation signals.
1	Response	response	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9714
# text = T cell activation results in high levels of HIV replication and is thought to be one mechanism leading to the conversion from latent to active viral infection.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	conversion	conversion	NOUN	NN	Number=Sing	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	latent	latent	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9715
# text = In HIV-1, the sequences that respond to these signaling events are found in the long terminal repeat (LTR) and comprise the transcriptional enhancer, which contains two conserved binding sites for the nuclear factor kappa B (NF kappa
1	In	in	ADP	IN	_	_	_	_	_
2	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	events	event	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
19	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
20	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	comprise	comprise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	two	two	NUM	CD	NumType=Card	_	_	_	_
33	conserved	conserve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	PROPN	NNP	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9716
# text = B).
1	B	b	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9717
# text = The corresponding region in the second AIDS retrovirus, HIV-2, contains a conserved and a divergent NF kappa B binding site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
8	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9718
# text = We demonstrate that the HIV-1 LTR responds better than the HIV-2 LTR to T cell activation signals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
9	responds	respond	NOUN	NNS	Number=Plur	_	_	_	_
10	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9719
# text = These qualitative differences in the response to T cell activation are reproduced not only when HIV-1 or HIV-2 enhancers are placed upstream of a heterologous promoter but also when these enhancers are switched between their respective LTR.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	qualitative	qualitative	ADJ	JJ	Degree=Pos	_	_	_	_
3	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	reproduced	reproduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	placed	place	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	when	when	ADV	WRB	PronType=Int	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
36	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	switched	switch	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	between	between	ADP	IN	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
41	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9720
# text = In electrophoretic mobility shift assays, NF kappa B binds to both conserved sites in the HIV-1 transcriptional enhancer and only to the single conserved site in the HIV-2 transcriptional enhancer.
1	In	in	ADP	IN	_	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	only	only	ADV	RB	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
27	conserved	conserve	ADJ	JJ	Degree=Pos	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9721
# text = Instead of NF kappa B, the activator protein 3 binds to the divergent site in HIV-2.
1	Instead	instead	ADV	RB	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9722
# text = In conclusion, HIV-1 and HIV-2 are differentially regulated by T cell activation signals, and this difference may account for the longer period of viral latency observed with HIV-2 than with HIV-1 infection.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	differentially	differentially	ADV	RB	_	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	longer	longer	ADJ	JJ	Degree=Pos	_	_	_	_
28	period	period	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
31	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
32	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	than	than	ADP	IN	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9723
# text = Document 0030011907 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011907	0030011907	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9724
# text = Involvement of NF-kappaB p50/p65 heterodimer in activation of the human pro-interleukin-1beta gene at two subregions of the upstream enhancer element.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	p65	p65	NUM	CD	NumType=Card	_	_	_	_
9	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	pro-interleukin	pro-interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	subregions	subregion	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9725
# text = A region between-3134 and -2729 bp upstream from the transcription site of the human pro-interleukin 1beta (proIL-1beta) gene was identified as an LPS-responsive enhancer element.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	3134	3134	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	2729	2729	NUM	CD	NumType=Card	_	_	_	_
9	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
10	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	pro-interleukin	pro-interleukin	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
35	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
36	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9726
# text = In this study, the influence of the sequences located between -3134 and -2987 on the transcriptional activity of the proIL-1beta gene in LPS-stimulated Raw 264.7 cells was examined in detail.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	3134	3134	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	2987	2987	NUM	CD	NumType=Card	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	proIL	proil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	Raw	Raw	PROPN	NNP	Number=Sing	_	_	_	_
33	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	detail	detail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9727
# text = The results obtained by transient transfection of fos -CAT constructs that contained serial 5'-deletion mutations showed that the region between -3134 and -3059 appears to be required for the induction of transcription by LPS.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
6	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
11	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	serial	serial	ADJ	JJ	Degree=Pos	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
19	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
20	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	3134	3134	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	-3059	-3059	NUM	CD	NumType=Card	_	_	_	_
29	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
32	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9728
# text = Gel shift assay studies with synthetic oligonucleotides corresponding to partial sequences of the latter region and nuclear extracts from stimulated cells revealed specific protein binding sites between -3110 and -3090 and between -3079 and -3059.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	oligonucleotides	oligonucleotides	NOUN	NNS	Number=Plur	_	_	_	_
8	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	between	between	ADP	IN	_	_	_	_	_
28	-3110	-3110	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	-3090	-3090	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	between	between	ADP	IN	_	_	_	_	_
33	-3079	-3079	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	-3059	-3059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9729
# text = These specific bindings were time and LPS dose dependent.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	bindings	bindings	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	time	time	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
8	dose	dose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9730
# text = The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF-kappaB components p50 and p65, and did not contain other NF-kappaB proteins (p52, c-Rel, Rel B), AP-1 proteins (c-Fos, C-Jun), CREB or C/EBPbeta (NF-IL6).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	against	against	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	both	both	ADV	RB	_	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	components	component	NOUN	NNS	Number=Plur	_	_	_	_
23	p50	p50	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
31	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
44	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	_
50	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
60	,	,	PUNCT	,	_	_	_	_	_
61	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
62	or	or	CCONJ	CC	_	_	_	_	_
63	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
64	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
65	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
68	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9731
# text = Mutation of either of the putative NF-kappaB-binding sites in the enhancer element decreased the LPS-stimulated transcriptional activity.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	either	either	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9732
# text = These data indicated that two NF-kappaB-binding sites, which are located between -3134 and -3059, are critical for the activation of proIL-1beta gene transcription.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	3134	3134	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	3059	3059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	proIL	proil	ADV	RB	_	_	_	_	SpaceAfter=No
30	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9733
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9734
# text = Document 0030011914 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011914	0030011914	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9735
# text = The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
9	positively	positively	ADV	RB	_	_	_	_	_
10	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9736
# text = Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) infection is associated with increased levels of viral replication and burden in the peripheral blood and lymphoid organs.
1	Clinical	Clinical	ADJ	JJ	Degree=Pos	_	_	_	_
2	deterioration	deterioration	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
22	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	burden	burden	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
28	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
31	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9737
# text = T cell activation and ensuing cellular gene activation can be critical for HIV-1 replication.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	ensuing	ensue	VERB	VBG	VerbForm=Ger	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9738
# text = The hypothesis that the nuclear factor of activated T cells (NF-AT) may influence HIV-1 replication is therefore compelling given the tight correlation of HIV-1 transcriptional induction to T cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	therefore	therefore	ADV	RB	_	_	_	_	_
24	compelling	compelling	ADJ	JJ	Degree=Pos	_	_	_	_
25	given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
28	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	T	T	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9739
# text = We report that certain NF-AT(Rel) family members productively bind the kappaB regulatory elements, synergize with NF-kappaB and Tat in transcriptional activation of HIV-1, and enhance HIV-1 replication in T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	members	member	NOUN	NNS	Number=Plur	_	_	_	_
13	productively	productively	ADV	RB	_	_	_	_	_
14	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	_
37	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9740
# text = These results link regulatory factors critical to T cell commitment directly to HIV-1 replication.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	link	link	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	T	t	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
11	directly	directly	ADV	RB	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9741
# text = Document 0030011921 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011921	0030011921	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9742
# text = Studies into the effect of tyrosine phosphatase inhibitor phenylarsine oxide on NFkappaB activation in T lymphocytes during aging: evidence for altered IkappaB-alpha phosphorylation and degradation.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	into	into	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	phenylarsine	phenylarsine	NOUN	NN	Number=Sing	_	_	_	_
10	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	aging	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9743
# text = Nuclear
1	Nuclear	nuclear	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 9744
# text = Factor kappa B (NFkappaB) is a critical regulator of several genes involved in immune and inflammatory responses.
1	Factor	factor	NOUN	NN	Number=Sing	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9745
# text = Treatment of T cells with a variety of stimuli, including TNF-alpha, leads to the translocation of the active p65-50 heterodimer to the nucleus, albeit at a lower level in T cells from the elderly.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	50	50	NUM	CD	NumType=Card	_	_	_	_
26	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	albeit	albeit	SCONJ	IN	_	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
35	level	level	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	elderly	elderly	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9746
# text = We demonstrate here that pretreatment with PAO results in the inhibition of NFkappaB induction in TNF-alpha treated T cells, suggesting a role for PAO-sensitive phosphatase in the activation of the NFkappaB via this pathway in human T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	PAO	pao	NOUN	NN	Number=Sing	_	_	_	_
8	results	result	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NFkappaB	Nfkappab	PROPN	NNP	Number=Sing	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	alpha	alpha	ADV	RB	_	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
30	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	via	via	ADP	IN	_	_	_	_	_
38	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
39	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9747
# text = Furthermore, it demonstrates that aging does not influence the sensitivity of this phosphatase.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	aging	age	VERB	VBG	VerbForm=Ger	_	_	_	_
7	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9748
# text = Treatment with DMP prior to treatment with PAO and TNF abolishes the inhibition induced by PAO, in T cells from both young and old donors, alike.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	DMP	DMP	PROPN	NNP	Number=Sing	_	_	_	_
4	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	treatment	treatment	VERB	VB	VerbForm=Inf	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
11	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	old	old	ADJ	JJ	Degree=Pos	_	_	_	_
26	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	alike	alike	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9749
# text = Finally, we demonstrate that a failure to degrade IkappaB-alpha in cytosols of TNF-treated T cells pretreated with PAO is due to its interference with the phosphorylation of IkappaB-alpha and not due to its inhibitory effect on proteasomal degradation.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	degrade	degrade	VERB	VB	VerbForm=Inf	_	_	_	_
10	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cytosols	cytosol	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	due	due	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	not	not	ADV	RB	_	_	_	_	_
38	due	due	ADP	IN	_	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
41	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
42	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
43	on	on	ADP	IN	_	_	_	_	_
44	proteasomal	proteasomal	ADJ	JJ	Degree=Pos	_	_	_	_
45	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9750
# text = These data collectively suggest that PAO interferes with the phosphorylation and the regulated degradation of IkappaB-alpha, induced by TNF, without affecting the chymotryptic activity of the proteasome, independent of age.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	collectively	collectively	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	PAO	pao	PROPN	NNP	Number=Sing	_	_	_	_
7	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	without	without	SCONJ	IN	_	_	_	_	_
25	affecting	affecte	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	chymotryptic	chymotryptic	ADJ	JJ	Degree=Pos	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9751
# text = Document 0030011923 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011923	0030011923	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9752
# text = Defining therapeutic targets by using adenovirus:
1	Defining	defining	VERB	VBG	VerbForm=Ger	_	_	_	_
2	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
3	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	SCONJ	IN	_	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 9753
# text = blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
1	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	destructive	destructive	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	synovium	synovium	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	spares	spare	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9754
# text = The role of the transcription factor NF-kappaB in the pathogenesis of rheumatoid arthritis has long been a subject of controversy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	long	long	ADV	RB	Degree=Pos	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	subject	subject	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	controversy	controversy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9755
# text = We used an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha, which has the advantage that it can be used in the diseased tissue itself, with >90% of the synovial macrophages, fibroblasts, and T cells infected.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	adenoviral	adenoviral	ADJ	JJ	Degree=Pos	_	_	_	_
5	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
17	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	diseased	diseased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
32	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	>	>	SYM	NFP	_	_	_	_	SpaceAfter=No
36	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	%	%	SYM	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
41	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	T	t	PROPN	NNP	Number=Sing	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9756
# text = We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammatory cytokines is NF-kappaB-dependent in rheumatoid synovial tissue, in contrast to the main anti-inflammatory mediators, like IL-10 and -11, and the IL-1 receptor antagonist.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
24	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
25	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
32	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	like	like	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	10	10	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	-11	-11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
48	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9757
# text = Of even more interest, IkappaBalpha overexpression inhibited the production of matrix metalloproteinases 1 and 3 while not affecting their tissue inhibitor.
1	Of	of	ADP	IN	_	_	_	_	_
2	even	even	ADV	RB	_	_	_	_	_
3	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
4	interest	interest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	matrix	matrix	NUM	CD	NumType=Card	_	_	_	_
13	metalloproteinases	metalloproteinase	NOUN	NNS	Number=Plur	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	while	while	SCONJ	IN	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9758
# text = Blocking NF-kappaB in the rheumatoid joint thus has a very beneficial profile, reducing both the inflammatory response and the tissue destruction.
1	Blocking	Blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	joint	joint	NOUN	NN	Number=Sing	_	_	_	_
9	thus	thus	ADV	RB	_	_	_	_	_
10	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	very	very	ADV	RB	_	_	_	_	_
13	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
14	profile	profile	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
24	destruction	destruction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9759
# text = The adenoviral technique described here has widespread applicability, allowing rapid testing of the effects of blocking a potential therapeutic target in either cultures of normal cells or in the diseased tissue itself.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adenoviral	adenoviral	ADJ	JJ	Degree=Pos	_	_	_	_
3	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	here	here	ADV	RB	PronType=Dem	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
8	applicability	applicability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
11	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
12	testing	testing	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
20	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
21	target	target	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	either	either	DET	DT	_	_	_	_	_
24	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	diseased	disease	ADJ	JJ	Degree=Pos	_	_	_	_
32	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
33	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9760
# text = Document 0030011927 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011927	0030011927	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9761
# text = The control of lytic replication of Epstein-Barr virus in B lymphocytes (Review).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Review	Review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9762
# text = Uncontrolled replication of a virus, which is harmful to the host is also disadvantageous to the virus.
1	Uncontrolled	Uncontroll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	harmful	harmful	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	host	host	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	disadvantageous	disadvantageous	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9763
# text = Most viruses cannot compete with the various immune mechanisms and become eliminated in the course of infection.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
4	not	not	PART	RB	_	_	_	_	_
5	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
13	eliminated	eliminated	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	course	course	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9764
# text = Therefore, only the time between infection and eradication remains for these viruses to proliferate.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	time	time	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	eradication	eradication	NOUN	NN	Number=Sing	_	_	_	_
10	remains	remain	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9765
# text = A few viruses, like the Herpesviruses or the papillomaviruses, however, have developed a sophisticated strategy for persisting lifelong, usually asymptomatically in the host, hiding from the immune system and producing infectious progeny at the same time.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
3	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	like	like	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Herpesviruses	Herpesviruse	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	papillomaviruses	papillomaviruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	sophisticated	sophisticate	ADJ	JJ	Degree=Pos	_	_	_	_
18	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	persisting	persist	VERB	VBG	VerbForm=Ger	_	_	_	_
21	lifelong	lifelong	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	usually	usually	ADV	RB	_	_	_	_	_
24	asymptomatically	asymptomatically	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	hiding	hide	VERB	VBG	VerbForm=Ger	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
33	system	system	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
36	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
37	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
38	at	at	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
41	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9766
# text = This strategy depends on a separation of latency and the lytic replication, either by time due to differentiation-dependent mechanisms or by spatial separation as the result of different host cell types.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
3	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	separation	separation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	time	time	NOUN	NN	Number=Sing	_	_	_	_
17	due	due	ADP	IN	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	spatial	spatial	ADJ	JJ	Degree=Pos	_	_	_	_
26	separation	separation	NOUN	NN	Number=Sing	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	result	result	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
32	host	host	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9767
# text = Both are true for the Epstein-Barr virus (EBV).
1	Both	both	DET	DT	_	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9768
# text = B cells and epithelial cells have a pivotal role in the life cycle of the virus.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	life	life	NOUN	NN	Number=Sing	_	_	_	_
13	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9769
# text = The former can become latently infected and are thought to be the virus reservoir in vivo, whereas the latter were shown to be permissive for lytic replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	former	former	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
5	latently	latently	ADV	RB	_	_	_	_	_
6	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9770
# text = However, replication of EBV in vivo is controlled primarily by host immune mechanisms selecting for cells that are not permissive for viral replication as the result of a particular set of transcription factors.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	primarily	primarily	ADV	RB	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	host	host	NOUN	NN	Number=Sing	_	_	_	_
13	immune	immune	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	selecting	selecte	VERB	VBG	VerbForm=Ger	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	result	result	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
31	set	set	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9771
# text = These factors control the activity of the regulatory immediate-early genes and, in addition, lytic and latent cycle regulatory genes negatively interfere with each other and thus link cellular and viral gene regulatory mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
21	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
22	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	negatively	negatively	ADV	RB	_	_	_	_	_
25	interfere	interfere	ADV	RB	PronType=Dem	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	each	each	DET	DT	_	_	_	_	_
28	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	thus	thus	ADV	RB	_	_	_	_	_
31	link	link	NOUN	NN	Number=Sing	_	_	_	_
32	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9772
# text = Disturbance of both the immune surveillance as well as viral gene regulation may result in EBV-associated disease.
1	Disturbance	Disturbance	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
6	surveillance	surveillance	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9773
# text = Document 0030011933 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011933	0030011933	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9774
# text = Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1).
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
28	PEBP2/	PEBP2/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
29	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9775
# text = The receptor for the macrophage colony-stimulating factor (or colony-stimulating factor 1 [CSF-1]) is expressed from different promoters in monocytic cells and placental trophoblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
6	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	or	or	CCONJ	CC	_	_	_	_	_
12	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	placental	placental	ADJ	JJ	Degree=Pos	_	_	_	_
33	trophoblasts	trophoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9776
# text = We have demonstrated that the monocyte-specific expression of the CSF-1 receptor is regulated at the level of transcription by a tissue-specific promoter whose activity is stimulated by the monocyte/B-cell-specific transcription factor PU.1 (D.-E.Zhang, C.J.Hetherington, H.-M.Chen, and D.G.Tenen, Mol.Cell.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	monocyte/B-cell	monocyte/B-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	D.	D.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	E.Zhang	E.Zhang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	C.J.Hetherington	C.J.Hetherington	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	H.-M.	H.-M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	Chen	Chen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	D.G.Tenen	D.G.Tenen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	Mol.Cell	Mol.Cell	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9777
# text = Biol.14:373-381, 1994).
1	Biol.14:373-381	Biol.14:373-381	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1994	1994	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9778
# text = Here we report that the tissue specificity of this promoter is also mediated by sequences in a region II (bp -88 to - 59), which lies 10 bp upstream from the PU.1-binding site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
7	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	88	88	NUM	CD	NumType=Card	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	_
26	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	10	10	NUM	CD	NumType=Card	_	_	_	_
32	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
33	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9779
# text = When analyzed by DNase footprinting, region II was protected preferentially in monocytic cells.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
5	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	PRON	PRP	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	preferentially	preferentially	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9780
# text = Electrophoretic mobility shift assays confirmed that region II interacts specifically with nuclear proteins from monocytic cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
10	specifically	specifically	ADV	RB	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9781
# text = Two gel shift complexes (Mono A and Mono B) were formed with separate sequence elements within this region.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
7	A	A	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9782
# text = Competition and supershift experiments indicate that Mono B contains a member of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family, which includes the AML1 gene product, while Mono A is a distinct complex preferentially expressed in monocytic cells.
1	Competition	competition	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	member	member	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	polyomavirus	polyomavirus	NOUN	NN	Number=Sing	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	core	core	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PEBP2/	PEBP2ith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	while	while	SCONJ	IN	_	_	_	_	_
39	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	no	no	DET	DT	_	_	_	_	_
41	A	a	NOUN	NN	Number=Sing	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
45	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
46	preferentially	preferentially	ADV	RB	_	_	_	_	_
47	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9783
# text = Promoter constructs with mutations in these sequence elements were no longer expressed specifically in monocytes.
1	Promoter	Promoter	NOUN	NN	Number=Sing	_	_	_	_
2	constructs	construct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	no	no	ADV	RB	_	_	_	_	_
11	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9784
# text = Furthermore, multimerized region II sequence elements enhanced the activity of a heterologous thymidine kinase promoter in monocytic cells but not other cell types tested.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	types	type	NOUN	NNS	Number=Plur	_	_	_	_
25	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9785
# text = These results indicate that the monocyte/B-cell-specific transcription factor PU.1 and the Mono A and Mono B protein complexes act in concert to regulate monocyte-specific transcription of the CSF-1 receptor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monocyte/B-cell	monocyte/B-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
15	A	a	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
21	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9786
# text = Document 0030011936 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011936	0030011936	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9787
# text = IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	cooperates	cooperate	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	latently	latently	ADV	RB	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	acutely	acutely	ADV	RB	_	_	_	_	_
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9788
# text = IL-10 is elevated in HIV-1-infected individuals and has been implicated in disease progression.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
18	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9789
# text = In this study, we investigated the effects of IL-10 on the activation of HIV-1 from infected monocytes and macrophages.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9790
# text = Although IL-10 alone did not induce HIV-1 replication, in the presence of TNF-alpha, IL-10 markedly enhanced virion production from a chronically infected promonocytic cell line (U1) and in acutely infected monocyte-derived macrophages.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	alone	alone	ADV	RB	_	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	10	10	NUM	CD	NumType=Card	_	_	_	_
25	markedly	markedly	ADV	RB	_	_	_	_	_
26	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	virion	virion	NOUN	NN	Number=Sing	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	chronically	chronically	ADV	RB	_	_	_	_	_
32	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	line	line	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	U1	U1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	acutely	acutely	ADV	RB	_	_	_	_	_
42	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9791
# text = Neutralizing mAbs to IL-10 and TNF-alpha indicated that both cytokines were essential for the induction and were required to generate a synergistic increase in virus expression.
1	Neutralizing	Neutralize	ADJ	JJ	Degree=Pos	_	_	_	_
2	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9792
# text = The effects of the two cytokines were distinguishable functionally since pretreatment with TNF-alpha attenuated the cytokine cooperativity, while pretreatment with IL-10 potentiated their cooperativity, suggesting that IL-10 and TNF-alpha play different roles in the activation of virus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	distinguishable	distinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
9	functionally	functionally	ADV	RB	_	_	_	_	_
10	since	since	ADP	IN	_	_	_	_	_
11	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
16	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	cooperativity	cooperativity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	while	while	SCONJ	IN	_	_	_	_	_
22	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	potentiated	potentiate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	cooperativity	cooperativity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	10	10	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
40	play	play	NOUN	NN	Number=Sing	_	_	_	_
41	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
42	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9793
# text = Northern blot analysis as well as Ab blocking and cytokine secretion studies indicated that the induction of either endogenous TNF-alpha or IL-10 was not involved in the cooperativity, nor was an up-regulation of TNF-alpha receptors.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	_
8	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
11	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
12	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
13	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	either	either	CCONJ	CC	_	_	_	_	_
19	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
20	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cooperativity	cooperativity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	nor	nor	CCONJ	CC	_	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
44	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9794
# text = In combination with TNF-alpha, IL-10 stimulated activating protein-1 (AP-1) and nuclear factor (NF)-kappa B binding activities and cooperated to increase HIV-1 steady-state mRNA levels and enhance long terminal repeat-directed transcription through activation of the NF-kappa B binding sites, suggesting the IL-10 effect occurs at least in part at the transcriptional level.
1	In	in	ADP	IN	_	_	_	_	_
2	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	cooperated	cooperate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
36	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	steady	steady	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	state	state	NOUN	NN	Number=Sing	_	_	_	_
42	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
43	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
46	long	long	ADV	RB	Degree=Pos	_	_	_	_
47	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
48	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
52	through	through	ADP	IN	_	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
59	B	b	NOUN	NN	Number=Sing	_	_	_	_
60	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
61	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
67	10	10	NUM	CD	NumType=Card	_	_	_	_
68	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
69	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
70	at	at	ADV	RB	_	_	_	_	_
71	least	least	ADV	RBS	Degree=Sup	_	_	_	_
72	in	in	ADP	IN	_	_	_	_	_
73	part	part	NOUN	NN	Number=Sing	_	_	_	_
74	at	at	ADP	IN	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
77	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9795
# text = These results indicate that IL-10, in addition to down-regulating the cellular immune response to HIV-1, may also play a role in TNF-alpha-mediated activation of HIV-1 replication in the monocyte/macrophage lineage.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
45	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
46	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9796
# text = Document 0030011937 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011937	0030011937	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9797
# text = Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
11	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
22	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9798
# text = T-lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, and is associated with a decrease in interleukin 2 (IL-2), gamma interferon, and granulocyte-macrophage colony-stimulating factor mRNA levels.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
3	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
10	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
11	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
24	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
42	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
48	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
51	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
52	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
53	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9799
# text = We report here that 1,25(OH)2D3-mediated repression in Jurkat cells is cycloheximide resistant, suggesting that it is a direct transcriptional repressive effect on IL-2 expression by the vitamin D3 receptor (VDR).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
18	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
37	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9800
# text = We therefore examined vitamin D3-mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with IL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
5	D3	D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	cotransfecting	cotransfect	VERB	VBG	VerbForm=Ger	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	VDR	VDR	ADJ	JJR	Degree=Cmp	_	_	_	_
30	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
31	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	by	by	SCONJ	IN	_	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9801
# text = We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3-mediated repression in vivo to a short 40-bp region encompassing an important positive regulatory element, NF-AT-1, which is bound by a T-cell-specific transcription factor, NFATp, as well as by AP-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	delineated	delineate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	conferring	conferr	VERB	VBG	VerbForm=Ger	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
28	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
35	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	which	which	PRON	WDT	PronType=Rel	_	_	_	_
46	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
47	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	as	as	ADV	RB	_	_	_	_	_
60	well	well	ADV	RB	Degree=Pos	_	_	_	_
61	as	as	ADP	IN	_	_	_	_	_
62	by	by	ADP	IN	_	_	_	_	_
63	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9802
# text = VDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the VDR DNA-binding domain alone, however, bound the element but also could not repress IL-2 expression.
1	VDR	VDR	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	bind	bind	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	repress	repress	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
27	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	bound	bound	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	also	also	ADV	RB	_	_	_	_	_
36	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9803
# text = These results indicate that DNA binding by VDR is necessary but not sufficient to mediate IL-2 repression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DNA	Dna	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9804
# text = By combining partially purified proteins in vitro, we observed the loss of the bound NFATp/AP-1-DNA complex upon inclusion of VDR or VDR-retinoid X receptor.
1	By	by	SCONJ	IN	_	_	_	_	_
2	combining	combi	VERB	VBG	VerbForm=Ger	_	_	_	_
3	partially	partially	ADV	RB	_	_	_	_	_
4	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
16	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	inclusion	inclusion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	X	x	NOUN	NN	Number=Sing	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9805
# text = Order of addition and off-rate experiments indicate that the VDR-retinoid X receptor heterodimer blocks NFATp/AP-1 complex formation and then stably associates with the NF-AT-1 element.
1	Order	order	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	off	off	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
9	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	_
15	X	x	ADP	IN	_	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
18	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
19	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	then	then	ADV	RB	PronType=Dem	_	_	_	_
28	stably	stably	ADV	RB	_	_	_	_	_
29	associates	associate	VERB	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	AT	at	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9806
# text = This direct inhibition by a nuclear hormone receptor of transcriptional activators of the IL-2 gene may provide a mechanistic explanation of how vitamin derivatives can act as potent immunosuppressive agents.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	mechanistic	mechanistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	SCONJ	IN	_	_	_	_	_
24	how	how	ADV	WRB	PronType=Int	_	_	_	_
25	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
26	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
27	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
28	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
31	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
32	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9807
# text = Document 0030011940 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011940	0030011940	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9808
# text = Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes.
1	Leukotriene	Leukotriene	PROPN	NNP	Number=Sing	_	_	_	_
2	B4	B4	PROPN	NNP	Number=Sing	_	_	_	_
3	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9809
# text = We have examined the effect of leukotriene B4 (LTB4), a potent lipid proinflammatory mediator, on the expression of the proto-oncogenes c-jun and c-fos.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	leukotriene	leukotriene	NOUN	NN	Number=Sing	_	_	_	_
8	B4	B4	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
15	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
16	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
26	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
27	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9810
# text = In addition, we looked at the modulation of nuclear factors binding specifically to the AP-1 element after LTB4 stimulation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	looked	look	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	LTB4	LTB4	NUM	CD	NumType=Card	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9811
# text = LTB4 increased the expression of the c-fos gene in a time- and concentration-dependent manner.
1	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	_
2	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9812
# text = The c-jun mRNA, which is constitutively expressed in human peripheral-blood monocytes at relatively high levels, was also slightly augmented by LTB4, although to a much lower extent than c-fos.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	relatively	relatively	ADV	RB	_	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	slightly	slightly	ADV	RB	_	_	_	_	_
24	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	although	although	SCONJ	IN	_	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
32	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
33	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
34	than	than	ADP	IN	_	_	_	_	_
35	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9813
# text = The kinetics of expression of the two genes were also slightly different, with c-fos mRNA reaching a peak at 15 min after stimulation and c-jun at 30 min.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	slightly	slightly	ADV	RB	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	with	with	X	GW	_	_	_	_	_
15	c-	c-	X	GW	_	_	_	_	SpaceAfter=No
16	fos	fo	X	GW	_	_	_	_	_
17	mRNA	mRNA	X	GW	_	_	_	_	_
18	reaching	reach	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	15	15	NUM	CD	NumType=Card	_	_	_	_
23	min	min	NOUN	NNS	Number=Plur	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	30	30	NUM	CD	NumType=Card	_	_	_	_
31	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9814
# text = Both messages rapidly declined thereafter.
1	Both	both	DET	DT	_	_	_	_	_
2	messages	message	NOUN	NNS	Number=Plur	_	_	_	_
3	rapidly	rapidly	ADV	RB	_	_	_	_	_
4	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	thereafter	thereafter	ADV	RB	_	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9815
# text = Stability of the c-fos and c-jun mRNA was not affected by LTB4, as assessed after actinomycin D treatment.
1	Stability	stability	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	actinomycin	actinomycin	ADP	IN	_	_	_	_	_
20	D	d	PROPN	NNP	Number=Sing	_	_	_	_
21	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9816
# text = Nuclear transcription studies in vitro showed that LTB4 increased the transcription of the c-fos gene 7-fold and the c-jun gene 1.4-fold.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	1.4	1.4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9817
# text = Resting monocytes contained nuclear factors binding to the AP-1 element, but stimulation of monocytes with LTB4 induced greater AP-1-binding activity of nuclear proteins.
1	Resting	rest	ADJ	JJ	Degree=Pos	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9818
# text = These results indicate that LTB4 may regulate the production of different cytokines by modulating the yield and/or the function of transcription factors such as AP-1-binding proto-oncogene products.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	yield	yield	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	or	or	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-oncogene	-oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
34	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9819
# text = Document 0030011942 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011942	0030011942	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9820
# text = Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
3	intermediates	intermediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	apparently	apparently	ADV	RB	_	_	_	_	_
6	widely	widely	ADV	RB	_	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9821
# text = Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes.
1	Hydrogen	Hydrogen	ADJ	JJ	Degree=Pos	_	_	_	_
2	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
5	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
8	commonly	commonly	ADV	RB	_	_	_	_	_
9	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9822
# text = In this study, we show that micromolar concentrations of H2O2 can induce the expression and replication of HIV-1 in a human T cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	micromolar	micromolar	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9823
# text = The effect is mediated by the NF-kappa B transcription factor which is potently and rapidly activated by an H2O2 treatment of cells from its inactive cytoplasmic form.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	potently	potently	ADV	RB	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
28	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
29	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9824
# text = N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2.
1	N-acetyl	N-acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-L-	-L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	well	well	ADV	RB	Degree=Pos	_	_	_	_
10	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	counteracts	counteract	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
19	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ROI	Roi	X	AFX	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	living	living	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9825
# text = NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	_
5	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
24	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
31	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
32	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9826
# text = This suggests that diverse agents thought to activate NF-kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
5	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
6	thought	think	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
18	all	all	ADV	RB	_	_	_	_	_
19	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
24	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9827
# text = ROI appear to serve as messengers mediating directly or indirectly the release of the inhibitory subunit I kappa B from NF-kappa B.
1	ROI	ROI	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
7	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	indirectly	indirectly	ADV	RB	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	release	release	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9828
# text = Document 0030011945 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011945	0030011945	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9829
# text = The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	product	product	NOUN	NN	Number=Sing	_	_	_	_
7	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	noncanonical	noncanonical	ADJ	JJ	Degree=Pos	_	_	_	_
23	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9830
# text = The interleukin-2 IL-2 receptor beta-chain (IL-2Rbeta) is an essential component of the receptors for IL-2 and IL-15.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-chain	-chain	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
20	component	component	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9831
# text = Although IL-2Rbeta is constitutively expressed by lymphocytes, its expression can be further induced by a number of stimuli, including phorbol 12-myristate 13-acetate (PMA).
1	Although	although	SCONJ	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	further	further	ADV	RB	_	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
25	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
26	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
29	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
31	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9832
# text = We have now characterized factors that bind to an enhancer region located between nucleotides -170 and -139 of the human IL-2Rbeta promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	170	170	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	139	139	NUM	CD	NumType=Card	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9833
# text = Both Sp1 and Sp3 bound to the 5' portion of this region, whereas a PMA-inducible factor (PIF) mainly bound to its 3' portion and bound to the Sp binding motifs as well.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Sp3	Sp3	NUM	CD	NumType=Card	_	_	_	_
5	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	's	PUNCT	``	_	_	_	_	_
10	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	PIF	PIF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	mainly	mainly	ADV	RB	_	_	_	_	_
25	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	'	'	PUNCT	``	_	_	_	_	_
30	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	Sp	sp	NOUN	NN	Number=Sing	_	_	_	_
36	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
37	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
38	as	as	ADV	RB	_	_	_	_	_
39	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9834
# text = In Jurkat T cells, induction of PIF DNA binding activity was rapidly induced, required de novo protein synthesis, and was sustained at a high level for at least 23 h.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PIF	PIF	NOUN	NN	Number=Sing	_	_	_	_
9	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	rapidly	rapidly	ADV	RB	_	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	de	de	X	FW	Foreign=Yes	_	_	_	_
18	novo	novo	ADJ	JJ	Degree=Pos	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=1|Tense=Past|VerbForm=Fin	_	_	_	_
24	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
28	level	level	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	at	at	ADV	RB	_	_	_	_	_
31	least	least	ADV	RBS	Degree=Sup	_	_	_	_
32	23	23	NUM	CD	NumType=Card	_	_	_	_
33	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9835
# text = Interestingly, PIF was constitutively activated in human T-cell leukemia virus type 1-transformed MT-2 cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PIF	PIF	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	constitutively	constitutively	ADV	RB	_	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	MT	mt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9836
# text = In this paper, we demonstrate that PIF is Egr-1 based on its recognition by anti-Egr-1 antisera in gel mobility shift assays, even though the IL-2Rbeta DNA binding motif differed substantially from the canonical Egr-1 binding site.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	PIF	PIF	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-1	-1	NUM	CD	NumType=Card	_	_	_	_
12	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	anti-Egr	anti-Egr	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	_
19	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
22	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
23	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
24	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	even	even	ADV	RB	_	_	_	_	_
27	though	though	SCONJ	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL-	Il-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	_
32	DNA	dna	PROPN	NNP	Number=Sing	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
35	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	substantially	substantially	ADV	RB	_	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	canonical	canonical	ADJ	JJ	Degree=Pos	_	_	_	_
40	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-1	-1	NUM	CD	NumType=Card	_	_	_	_
42	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
43	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9837
# text = In addition, Egr-1 bound to the Sp binding site.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	bound	bound	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Sp	sp	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9838
# text = In Jurkat cells, both sites were required for maximal IL-2Rbeta promoter activity, and in HeLaS3 cells, transfection of Egr-1 could drive activity of a reporter construct containing both sites.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	HeLaS3	HeLaS3	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	_
27	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
28	drive	drive	VERB	VB	VerbForm=Inf	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
33	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
34	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
35	both	both	DET	DT	_	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9839
# text = Moreover, Sp1 and Egr-1 could form a complex with kinetics that correlated with the production of Egr-1 in Jurkat cells upon PMA stimulation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-1	-1	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9840
# text = Thus, Sp1 and Egr-1 physically and functionally cooperate to mediate maximal IL-2Rbeta promoter activity.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	_
7	physically	physically	ADV	RB	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	functionally	functionally	ADV	RB	_	_	_	_	_
10	cooperate	cooperate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
13	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9841
# text = Document 0030011947 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011947	0030011947	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9842
# text = Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection.
1	Processing	processing	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9843
# text = Transcription of the human immunodeficiency virus type-1 (HIV-1) genome is regulated in part by cellular factors and is stimulated by activation of latently infected T cells.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	part	part	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	latently	latently	ADV	RB	_	_	_	_	_
30	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9844
# text = T-cell activation also correlates with the induction of the factor NF-kappa B which binds to two adjacent sites in the HIV-1 long terminal repeat.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9845
# text = This factor consists of two DNA-binding subunits of relative molecular mass 50,000 (50K) associated with two 65K subunits.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
14	50,000	50,000	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	K	k	NUM	CD	NumType=Card	_	_	_	_
24	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9846
# text = It is located in the nucleus in mature B cells, but is present in other cell types as an inactive cytoplasmic complex.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9847
# text = External stimuli, including those that activate T cells, result in nuclear translocation of active NF-kappa B.
1	External	external	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
5	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	result	result	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9848
# text = The cloning of the complementary DNA for the 50K subunit helped to identify an exclusively cytoplasmic 105K precursor (p105) (V.B., P.K. and A.I., manuscript submitted).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	K	k	NUM	CD	NumType=Card	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	helped	help	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	exclusively	exclusively	ADV	RB	_	_	_	_	_
17	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
18	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	K	k	NUM	CD	NumType=Card	_	_	_	_
20	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	V.B.	V.B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	P.K.	P.K.	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	A.I.	A.I.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	manuscript	manuscript	NOUN	NN	Number=Sing	_	_	_	_
32	submitted	submit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9849
# text = The expression of active NF-kappa B might therefore also be regulated by the extent of processing of p105.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
10	therefore	therefore	ADV	RB	_	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9850
# text = Because HIV-1 requires active NF-kappa B for efficient transcription, we tested the effect of HIV-1 infection on the processing of the human 105K precursor.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	K	k	NUM	CD	NumType=Card	_	_	_	_
32	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9851
# text = We show here that the HIV-1 protease can process p105 and increases levels of active nuclear NF-kappa B complex.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	process	process	VERB	VB	VerbForm=Inf	_	_	_	_
12	p105	p105	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9852
# text = Document 0030011949 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011949	0030011949	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9853
# text = Transcription specific differences visualized by fluorescence in situ hybridization pattern on interphase nuclei of different cell types.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
4	visualized	visualize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
9	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
10	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	interphase	interphase	ADJ	JJ	Degree=Pos	_	_	_	_
13	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9854
# text = Application of a "formamide free" and thus "material preserving" in situ hybridization technique using the cDNA of the myf3 gene revealed the following results: Human rhabdomyosarcoma cells, characterized by a high expression of myf3 show intensive hybridization signals in their interphase.
1	Application	application	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
5	formamide	formamide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
6	free	free	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	"	"	PUNCT	''	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	thus	thus	ADV	RB	_	_	_	_	_
10	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
11	material	material	ADJ	JJ	Degree=Pos	_	_	_	_
12	preserving	preserve	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	"	"	PUNCT	''	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
16	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
17	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	myf3	myf3	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	PRON	NN	Number=Sing	_	_	_	_
25	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	rhabdomyosarcoma	rhabdomyosarcoma	NOUN	NN	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	myf3	myf3	NUM	CD	NumType=Card	_	_	_	_
41	show	show	NOUN	NN	Number=Sing	_	_	_	_
42	intensive	intensive	ADJ	JJ	Degree=Pos	_	_	_	_
43	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
44	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
47	interphase	interphase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9855
# text = RNase treatment prior to hybridization considerably reduces the size of this signals.
1	RNase	RNase	NOUN	NN	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
6	considerably	considerably	ADV	RB	_	_	_	_	_
7	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	size	size	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9856
# text = In comparison, isolated nuclei of human lymphocytes in which no need for the expression of this gene exists, show barely hybridization signals.
1	In	in	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	need	need	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	show	show	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
22	barely	barely	ADV	RB	_	_	_	_	_
23	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
24	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9857
# text = Correspondingly,
1	Correspondingly	Correspondingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 9858
# text = RNase treatment had no effect on hybridization pattern at all.
1	RNase	RNase	ADJ	JJ	Degree=Pos	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
8	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
9	at	at	ADV	RB	_	_	_	_	_
10	all	all	ADV	RB	_	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9859
# text = In conclusion an increased transcription efficiency of a cell type specific gene is accompanied by a higher hybridization accessibility in the corresponding cell nuclei.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
18	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
19	accessibility	accessibility	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9860
# text = Document 0030011953 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011953	0030011953	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9861
# text = Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells.
1	Protease	Protease	NOUN	NN	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	distinguishes	distinguish	NOUN	NNS	Number=Plur	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	class	class	NOUN	NN	Number=Sing	_	_	_	_
9	II	ii	NUM	CD	NumType=Card	_	_	_	_
10	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
11	X1	X1	PROPN	NNP	Number=Sing	_	_	_	_
12	box	box	NOUN	NN	Number=Sing	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9862
# text = The X box region is critical for directing the expression of class II major histocompatibility complex genes in B lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	X	x	NOUN	NN	Number=Sing	_	_	_	_
3	box	box	NOUN	NN	Number=Sing	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9863
# text = Although several class II promoter-specific DNA binding factors have been described, only the X box region factor, RFX, shows a genetic correlation with class II expression, being deficient in some B cell lines derived from patients with class II-deficient congenital immunodeficiency.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
3	class	class	NOUN	NN	Number=Sing	_	_	_	_
4	II	ii	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	X	x	NOUN	NN	Number=Sing	_	_	_	_
18	box	box	NOUN	NN	Number=Sing	_	_	_	_
19	region	region	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	RFX	Rfx	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
27	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	class	class	NOUN	NN	Number=Sing	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
34	deficient	deficient	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	some	some	DET	DT	_	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
40	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	class	class	NOUN	NN	Number=Sing	_	_	_	_
45	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
48	congenital	congenital	ADJ	JJ	Degree=Pos	_	_	_	_
49	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9864
# text = To further evaluate the role of X box DNA-binding proteins in class II gene expression, the role of the X box region was examined in both class II-positive and -negative lymphoid cells.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	X	x	NOUN	NN	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	X	x	PROPN	NNP	Number=Sing	_	_	_	_
24	box	box	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	class	class	NOUN	NN	Number=Sing	_	_	_	_
31	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
37	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9865
# text = In addition to the wild-type B cell line Raji, two class II transcriptional mutant cell lines, SJO and RJ2.2.5, and Jurkat, a class II negative T cell line, were examined.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	SJO	SJO	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	RJ	RJ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	2.2.5	2.2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	class	class	NOUN	NN	Number=Sing	_	_	_	_
31	II	ii	NUM	CD	NumType=Card	_	_	_	_
32	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9866
# text = In contrast to wild-type B cells, neither of the class II mutant cell lines could use the X box region to direct the expression of a transiently transfected reporter gene, indicating that the X box-dependent transcriptional pathway is defective in these cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	neither	neither	DET	DT	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	class	class	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	_
15	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	use	use	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	X	x	NOUN	NN	Number=Sing	_	_	_	_
22	box	box	NOUN	NN	Number=Sing	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	direct	direct	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	transiently	transiently	ADV	RB	_	_	_	_	_
31	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	X	x	PROPN	NNP	Number=Sing	_	_	_	_
39	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9867
# text = The binding activity of the X1 box DNA-binding protein RFX was examined and found to be present in wild-type B cells and the mutant RJ2.2.5 but was absent in SJO and Jurkat.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	X1	X1	PROPN	NNP	Number=Sing	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	RFX	Rfx	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
29	RJ2.2.5	Rj2.2.5	NOUN	NN	Number=Sing	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	SJO	SJO	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9868
# text = However, other X1 box-specific activities were detected in all these cell lines.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	X1	X1	NOUN	NN	Number=Sing	_	_	_	_
5	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	all	all	DET	PDT	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9869
# text = To determine whether these different X1 box activities represented distinct DNA binding proteins or multimeric forms of the same factor(s), protease treatment of the crude nuclear extracts followed by DNA-binding assays were carried out and demonstrated that B cell extracts contain at least two X1-specific factors.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	X1	X1	NOUN	NN	Number=Sing	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
9	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	multimeric	multimeric	ADJ	JJ	Degree=Pos	_	_	_	_
16	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	s	s	X	AFX	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	protease	protease	ADJ	JJ	Degree=Pos	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	crude	crude	ADJ	JJ	Degree=Pos	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
32	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
37	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	out	out	ADP	RP	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
47	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
48	at	at	ADV	RB	_	_	_	_	_
49	least	least	ADV	RBS	Degree=Sup	_	_	_	_
50	two	two	NUM	CD	NumType=Card	_	_	_	_
51	X1	X1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
54	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9870
# text = One of these cleaved products (band 1 pk) correlates with RFX activity.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	cleaved	cleaved	ADJ	JJ	Degree=Pos	_	_	_	_
5	products	product	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	band	band	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	pk	pk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	RFX	RFX	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9871
# text = A similar comparison with protease-treated extracts prepared from Jurkat cells demonstrated the presence of the band 1pk activity despite an absence of the native RFX activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	protease	protease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	band	band	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	pk	pk	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	despite	despite	ADP	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
28	RFX	RFX	NOUN	NN	Number=Sing	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9872
# text = In contrast, protease treatment and analysis of SJO extracts showed no detectable levels of the band 1pk activity.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	SJO	SJO	PROPN	NNP	Number=Sing	_	_	_	_
10	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	no	no	DET	DT	_	_	_	_	_
13	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	band	band	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	pk	pk	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9873
# text = These results demonstrate that multiple X1 box-specific DNA-binding activities exist in all lymphoid cells, but the presence of an actively binding RFX species correlates with class II transcription.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	X1	X1	NOUN	NN	Number=Sing	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
14	exist	exist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	actively	actively	ADV	RB	_	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	RFX	RFX	PROPN	NNP	Number=Sing	_	_	_	_
28	species	species	NOUN	NNS	Number=Plur	_	_	_	_
29	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	class	class	NOUN	NN	Number=Sing	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9874
# text = Document 0030011958 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011958	0030011958	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9875
# text = Differential RNA display identifies novel genes associated with decreased vitamin D receptor expression.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
3	display	display	NOUN	NN	Number=Sing	_	_	_	_
4	identifies	identify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
11	D	d	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9876
# text = To characterize further the function of the intracellular vitamin D receptor (VDR), we have developed stable transfectant variants of a vitamin D-responsive cell line (U937) which express either decreased or increased numbers of VDR.
1	To	to	PART	TO	_	_	_	_	_
2	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
3	further	further	ADV	RBR	Degree=Cmp	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
10	D	d	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
20	transfectant	transfectant	ADJ	JJ	Degree=Pos	_	_	_	_
21	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
25	D-	D-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
34	either	either	CCONJ	CC	_	_	_	_	_
35	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9877
# text = In this study we have analyzed changes in gene expression associated with this variable VDR expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
15	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9878
# text = Initial experiments indicated that a 50% decrease in VDR levels was associated with a 2-fold increase in cell proliferation and a similar rise in c-myc mRNA expression.
1	Initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	%	%	SYM	NN	Number=Sing	_	_	_	_
8	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	VDR	Vdr	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
30	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9879
# text = Further studies were carried out using differential RNA display (DD).
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	out	out	ADP	RP	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
8	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
9	display	display	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	DD	D	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9880
# text = Sequence analysis of DD products revealed two cDNAs with identity to known gene products: the catalytic sub-unit of DNA-protein kinase (DNA-PK(CS)), and the peroxisomal enzyme 17beta-hydroxysteroid dehydrogenase type IV (17beta-HSD IV).
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DD	DD	PROPN	NNP	Number=Sing	_	_	_	_
5	products	product	NOUN	NNS	Number=Plur	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	sub-unit	sub-unit	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	PK	PK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	CS	CS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	peroxisomal	peroxisomal	ADJ	JJ	Degree=Pos	_	_	_	_
36	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
37	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	hydroxysteroid	hydroxysteroid	NOUN	NN	Number=Sing	_	_	_	_
40	dehydrogenase	dehydrogenase	NOUN	NN	Number=Sing	_	_	_	_
41	type	type	NOUN	NN	Number=Sing	_	_	_	_
42	IV	iv	PROPN	NNP	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	17beta	17beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	HSD	Hsd	PROPN	NNP	Number=Sing	_	_	_	_
47	IV	iv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9881
# text = Northern analysis confirmed that expression of both mRNAs was reduced in cells with decreased numbers of VDR.
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9882
# text = Down-regulation of 17beta-HSD IV mRNA expression was associated with enhanced estradiol inactivation by U937 cells, suggesting a link between estrogenic pathways and cell proliferation.
1	Down	down	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	HSD	Hsd	NOUN	NN	Number=Sing	_	_	_	_
8	IV	iv	NOUN	NN	Number=Sing	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	_
16	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	U937	U937	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	link	link	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	estrogenic	estrogenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9883
# text = Further Northern analyses indicated that there was no significant change in 17beta-HSD IV or DNA-PK(CS) mRNA levels following treatment with 1,25(OH)2D3, although expression of both genes varied with changes in cell proliferation.
1	Further	further	ADV	RB	_	_	_	_	_
2	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	there	there	PRON	EX	_	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	change	change	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	HSD	Hsd	NOUN	NN	Number=Sing	_	_	_	_
15	IV	iv	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	PK	Pk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CS	CS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	although	although	SCONJ	IN	_	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	both	both	DET	DT	_	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	varied	varied	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9884
# text = These data suggest that, in addition to its established role as a hormone-dependent trans-activator, VDR may influence gene expression by ligand-independent mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
24	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
30	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9885
# text = Document 0030011959 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011959	0030011959	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9886
# text = Mapping of the transcriptional repression domain of the lymphoid-specific transcription factor oct-2A.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
6	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	oct	oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9887
# text = The lymphoid-specific transcription factor Oct-2a is implicated in B cell-specific transcriptional activity via the octamer motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	via	via	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
23	motif.	motif.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9888
# text = Structure/function analysis of various Oct-2a effector regions in the context of the GAL4 DNA-binding domain revealed that Oct-2a contains two functionally different activation domains at the N and the C termini.
1	Structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
7	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
12	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	context	context	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	GAL4	GAL4	PROPN	NNP	Number=Sing	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	contains	contain	NOUN	NN	Number=Sing	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	functionally	functionally	ADV	RB	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	N	N	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	C	C	NOUN	NN	Number=Sing	_	_	_	_
41	termini	termini	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9889
# text = The transcriptional activity of both domains is strongly potentiated by interactions with distinct B cell-specific coactivators.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	strongly	strongly	ADV	RB	_	_	_	_	_
9	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	coactivators	coactivator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9890
# text = Recently, we have identified a repression domain located within the N terminus of Oct-2a (amino acids 2-99).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	N	N	PROPN	NNP	Number=Sing	_	_	_	_
13	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
20	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	99	99	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9891
# text = When this domain was transferred to a potent activator, transcription was strongly inhibited.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	transferred	transfer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
9	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	strongly	strongly	ADV	RB	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9892
# text = In this study we present a deletion analysis of the N-terminal region of Oct-2a to determine the minimal repression domain.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	present	present	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2a	2a	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
22	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9893
# text = We identified a stretch of 23 amino acids, rich in serine and threonine residues, which was responsible for most of the repression activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	stretch	stretch	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	23	23	NUM	CD	NumType=Card	_	_	_	_
7	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
8	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
15	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9894
# text = We show that repression is strongly dependent on the type of enhancer present in the reporter plasmid as well as on the cell line tested.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	strongly	strongly	ADV	RB	_	_	_	_	_
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	_
25	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9895
# text = The possibility that Oct-2a can act as an activator and/or a repressor may have important consequences for the function of Oct-2a in B cell differentiation and other developmental processes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	a	a	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	or	or	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
36	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
37	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9896
# text = Document 0030011964 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011964	0030011964	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9897
# text = The tumour associated cell surface antigen A6H is costimulatory for human CD4+ but not CD8+ T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	A6H	A6h	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	T	t	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9898
# text = The A6H monoclonal antibody (mAb) recognizes a 120,000-140,000 MW antigen that is expressed at similar densities on 85-90% of human CD4+ and CD8+ T cells and on renal cell carcinomas.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	A6	a6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	H	h	PROPN	NNP	Number=Sing	_	_	_	_
4	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	120,000	120,000	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	140,000	140,000	NUM	CD	NumType=Card	_	_	_	_
14	MW	Mw	ADJ	JJ	Degree=Pos	_	_	_	_
15	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
21	densities	density	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	85	85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	+	+	SYM	SYM	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	+	+	SYM	SYM	_	_	_	_	_
34	T	t	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	on	on	ADP	IN	_	_	_	_	_
38	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9899
# text = The binding of the A6H mAb induced a costimulatory signal in anti-CD3 activated T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	A6	a6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	H	H	PROPN	NNP	Number=Sing	_	_	_	_
7	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
8	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	T	t	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9900
# text = In the present report, we show that A6H costimulated cell proliferation and cytokine production in purified CD4+ T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	A6H	A6h	DET	DT	_	_	_	_	_
10	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
18	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9901
# text = Unexpectedly, the CD8+ T-cell subpopulation failed to respond.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	subpopulation	subpopulation	NOUN	NN	Number=Sing	_	_	_	_
9	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9902
# text = CD4+ T cells costimulated with the A6H mAb upregulated CD80, CD86, CD71, interleukin-2 (IL-2)R alpha, IL-2R beta and IL-2R gamma, while no corresponding up-regulation of these cell surface molecules was seen in CD8+ T cells.
1	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	+	+	SYM	SYM	_	_	_	_	_
3	T	t	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	A6	a6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	H	H	PROPN	NNP	Number=Sing	_	_	_	_
10	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
11	upregulated	upregulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CD86	CD86	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	CD71	CD71	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	X	LS	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	R	r	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
32	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	while	while	SCONJ	IN	_	_	_	_	_
40	no	no	DET	DT	_	_	_	_	_
41	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
42	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
49	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
50	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
51	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	+	+	SYM	SYM	_	_	_	_	_
55	T	t	NUM	CD	NumType=Card	_	_	_	_
56	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9903
# text = In order to investigate the nature of the A6H mAb costimulus at the transcriptional level we have examined induction of the transcription factors OCT-1, AP-1 and NF-kappa B which are known to be transcriptional regulators of several cytokine and cytokine receptor genes, including the IL-2 and IL-2R genes.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	A6	a6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	H	H	PROPN	NNP	Number=Sing	_	_	_	_
11	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
12	costimulus	costimulus	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	OCT	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
42	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
45	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
48	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
49	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	2	2	NUM	CD	NumType=Card	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
60	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9904
# text = Co-ligation of the A6H antigen and the CD3 complex induced expression of the transcription factor AP-1 in CD4+ T cells, whereas no increase in NF-kappa B and octamer-binding (Oct) proteins was seen compared to T cells stimulated with anti-CD3 alone.
1	Co	co	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-ligation	-ligation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	A6	A6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	H	h	PROPN	NNP	Number=Sing	_	_	_	_
7	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+	+	SYM	SYM	_	_	_	_	_
24	T	t	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	whereas	whereas	SCONJ	IN	_	_	_	_	_
28	no	no	DET	DT	_	_	_	_	_
29	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
43	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
44	seen	see	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	with	with	ADP	IN	_	_	_	_	_
51	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
52	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9905
# text = Furthermore, no induction of AP-1 was seen in A6H costimulated CD8+ T cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	A6H	A6h	PROPN	NNP	Number=Sing	_	_	_	_
13	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9906
# text = These results suggests that both proximal steps in CD8+ T-cell activation as well as the later phases are unresponsive to A6H ligation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
7	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T-	T-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
19	phases	phase	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	A6H	A6h	DET	DT	_	_	_	_	_
24	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9907
# text = Molecular differences of the A6H molecule or distinct regulation of the A6H transduced AP-1 activation pathway may exist in CD4+ and CD8+ T cell subpopulations.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	A6	A6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	H	h	PROPN	NNP	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	A6H	A6h	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	+	+	SYM	SYM	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	+	+	SYM	SYM	_	_	_	_	_
28	T	t	NUM	CD	NumType=Card	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	subpopulations	subpopulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9908
# text = Document 0030011965 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011965	0030011965	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9909
# text = Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	type-	type-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
21	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	Y	y	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	family	family	NOUN	NN	Number=Sing	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9910
# text = The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	rapidly	rapidly	ADV	RB	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	potently	potently	ADV	RB	_	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9911
# text = Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified.
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	299	299	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	228	228	NUM	CD	NumType=Card	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	CArG	Carg	NOUN	NN	Number=Sing	_	_	_	_
21	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9912
# text = We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	essential	essential	NOUN	NN	Number=Sing	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	137	137	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	64	64	NUM	CD	NumType=Card	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9913
# text = This element had maximal activity in lymphoid cells, paralleling the cell type specificity of Elf-1 expression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	paralleling	parallel	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9914
# text = Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	when	when	ADV	WRB	PronType=Int	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Y	y	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9915
# text = Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	137	137	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	64	64	NUM	CD	NumType=Card	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	7	7	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9916
# text = Elf-1 physically associated with HMG-I and with NF-kappa B p50 and c-Rel in vitro, suggesting that protein-protein interactions might functionally coordinate the actions of the upstream and downstream positive regulatory elements.
1	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	physically	physically	ADV	RB	_	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
29	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
30	functionally	functionally	ADV	RB	_	_	_	_	_
31	coordinate	coordinate	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
39	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
40	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
41	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9917
# text = This is the first report of a physical interaction between an Ets family member and NF-kappa B family proteins.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	member	member	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9918
# text = These findings provide significant new insights into the protein-protein and protein-DNA interactions that regulate cell-type-specific and inducible IL-2R alpha gene expression and also have implications for other genes regulated by Elf-1 and NF-kappa B family proteins.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-type-specific	-type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	X	LS	_	_	_	_	SpaceAfter=No
25	R	r	X	GW	_	_	_	_	_
26	alpha	alpha	X	GW	_	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	also	also	ADV	RB	_	_	_	_	_
31	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	family	family	NOUN	NN	Number=Sing	_	_	_	_
47	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9919
# text = Document 0030011968 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011968	0030011968	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9920
# text = LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha.
1	LMP	Lmp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
5	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
13	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	B	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha.	alpha.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 9921
# text = LMP-1, an Epstein-Barr virus membrane protein expressed during latent infection, has oncogenic properties, as judged from its ability to transform B lymphocytes and rodent fibroblasts.
1	LMP	Lmp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
15	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
19	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	judged	judged	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	transform	transform	VERB	VB	VerbForm=Inf	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	rodent	rodent	ADJ	JJ	Degree=Pos	_	_	_	_
32	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9922
# text = LMP-1 induces the expression of bcl2, an oncogene which protects cells from apoptosis, as well as of genes encoding other proteins involved in cell regulation and growth control.
1	LMP	Lmp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	bcl2	bcl2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	protects	protect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9923
# text = The mechanisms by which LMP-1 upregulates these proteins is unknown, but it is plausible that LMP-1 modifies signal transduction pathways that result in the activation of one or more transcription factors that ultimately regulate transcription of oncogenic genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	DET	WDT	PronType=Int	_	_	_	_
5	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	upregulates	upregulate	NOUN	NNS	Number=Plur	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	plausible	plausible	ADJ	JJ	Degree=Pos	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	LMP	LMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	modifies	modify	NOUN	NNS	Number=Plur	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
25	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	result	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	one	one	NUM	CD	NumType=Card	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
37	that	that	PRON	WDT	PronType=Rel	_	_	_	_
38	ultimately	ultimately	ADV	RB	_	_	_	_	_
39	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
43	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9924
# text = NF-kappa B, a transcription factor controlling the expression of genes involved in cell activation and growth control, has been shown to be activated by LMP-1.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
4	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9925
# text = The mechanism(s) regulating this activation remains unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9926
# text = Our data indicate that increased NF-kappa B DNA binding and functional activity are present in B-lymphoid cells stably or transiently expressing LMP-1.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	stably	stably	ADV	RB	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	transiently	transiently	ADV	RB	_	_	_	_	_
25	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
26	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9927
# text = I kappa B alpha is selectively modified in LMP-1-expressing B cells.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	selectively	selectively	ADV	RB	_	_	_	_	_
7	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9928
# text = A phosphorylated form of I kappa B alpha and increased protein turnover-degradation correlate with increased NF-kappa B nuclear translocation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
15	correlate	correlate	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9929
# text = This results in increased transcription of NF-kappa B-dependent-genes, including those encoding p105 and I kappa B alpha (MAD3).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
18	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
19	p105	p105	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	B	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	MAD3	MAD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9930
# text = These results indicate that LMP-1 activates NF-kappa B in B-cell lines by targeting I kappa B alpha.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	targeting	targete	VERB	VBG	VerbForm=Ger	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9931
# text = Identification of the pathways activated by LMP-1 to result in posttranslational modifications of I kappa B alpha will aid in determining the role of this virus-host cell protein interaction in Epstein-Barr virus-mediated oncogenesis.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	posttranslational	posttranslational	ADJ	JJ	Degree=Pos	_	_	_	_
14	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
21	aid	aid	VERB	VB	VerbForm=Inf	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	host	host	NOUN	NN	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
38	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	oncogenesis	oncogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9932
# text = Document 0030011975 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011975	0030011975	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9933
# text = Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils.
1	Granulocyte	Granulocyte	PROPN	NNP	Number=Sing	_	_	_	_
2	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	72	72	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9934
# text = Granulocyte colony-stimulating factor (G-CSF) signaling involves activation of STATs, proteins that serve the dual function of signal transduction and activation of transcription.
1	Granulocyte	Granulocyte	PROPN	NNP	Number=Sing	_	_	_	_
2	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
11	involves	involve	NOUN	NNS	Number=Plur	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STATs	STAT	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	serve	serve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9935
# text = We previously demonstrated that G-CSF activated a distinct Stat3-like protein in immature and mature normal myeloid cells, StatG.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	G-	G-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
7	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	StatG	StatG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9936
# text = StatG in normal immature human myeloid cells, i.e. adult CD34+ bone marrow cells, was composed of Stat3beta.
1	StatG	Statg	PRON	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	i.e.	i.e.	X	FW	_	_	_	_	_
10	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
11	CD34	CD34	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
14	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9937
# text = This investigation was undertaken to determine the composition of StatG in mature normal human myeloid cells, i.e. polymorphonuclear neutrophilic granulocytes (PMN).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	StatG	Statg	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	i.e.	i.e.	X	FW	_	_	_	_	_
19	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	neutrophilic	neutrophilic	ADJ	JJ	Degree=Pos	_	_	_	_
21	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	PMN	Pmn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9938
# text = These studies revealed that the major protein in extracts of PMN activated by G-CSF to bind the high-affinity serum-inducible element (hSIE) is a 72-kDa protein that cross-reacts with Stat3 monoclonal antibody, which we have designated Stat3gamma.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PMN	PMN	PROPN	NNP	Number=Sing	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
22	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
25	element	element	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	hSIE	hsie	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	72	72	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	cross-reacts	cross-react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
39	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
40	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	which	which	PRON	WDT	PronType=Rel	_	_	_	_
43	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
44	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9939
# text = Stat3gamma is derived from Stat3alpha by limited proteolysis and lacks the carboxyl-terminal portion of Stat3alpha.
1	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
17	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9940
# text = Because this region of Stat3alpha is involved in transcriptional activation, our findings suggest the possibility that Stat3gamma may be transcriptionally inactive and may compete with Stat3alpha for Stat3 binding sites in these terminally differentiated myeloid cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
14	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
15	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
24	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
33	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	terminally	terminally	ADV	RB	_	_	_	_	_
38	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9941
# text = Document 0030011978 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011978	0030011978	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9942
# text = NF-kappa B-independent suppression of HIV expression by ascorbic acid.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
7	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	ascorbic	ascorbic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9943
# text = Ascorbic acid (ascorbate or vitamin C) has been shown to suppress the induction of HIV in latently infected T lymphocytic cells following stimulation with a tumor promoter (PMA) and inflammatory cytokine (TNF-alpha).
1	Ascorbic	Ascorbic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	latently	latently	ADV	RB	_	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9944
# text = To assess whether this inhibition was mediated via modulation of the cellular transcription factor, NF-kappa B, we carried out gel shift analysis on nuclear extracts prepared under different conditions of cell stimulation in the presence or absence of ascorbate, N-acetylcysteine (NAC), or zidovudine (AZT).
1	To	to	PART	TO	_	_	_	_	_
2	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	via	via	ADP	IN	_	_	_	_	_
9	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	out	out	ADP	RP	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
30	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	under	under	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	or	or	CCONJ	CC	_	_	_	_	_
52	zidovudine	zidovudine	NOUN	NN	Number=Sing	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	AZT	AZT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9945
# text = Pretreatment of ACH-2 T cells by NAC followed by stimulation with PMA, TNF-alpha, or hydrogen peroxide (H2O2) resulted in strong suppression of NF-kappa B activation.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ACH	ACH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
10	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	hydrogen	hydrogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
30	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9946
# text = In contrast, neither ascorbate nor AZT affected NF-kappa B activity under all three induction conditions in the ACH-2 cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	neither	neither	CCONJ	CC	_	_	_	_	_
5	ascorbate	ascorbate	ADJ	JJ	Degree=Pos	_	_	_	_
6	nor	nor	CCONJ	CC	_	_	_	_	_
7	AZT	Azt	ADV	RB	_	_	_	_	_
8	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	under	under	ADP	IN	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9947
# text = Ascorbate and AZT also had no effect on NF-kappa B activation following TNF-alpha- or PMA-induced stimulation of U1 promonocytic cells.
1	Ascorbate	Ascorbate	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	AZT	AZT	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	U1	U1	NUM	CD	NumType=Card	_	_	_	_
26	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9948
# text = These results suggest that the molecular mechanism of HIV inhibition by ascorbate is not mediated via NF-kappa B inhibition, unlike that seen with other antioxidants.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	ascorbate	ascorbate	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	unlike	unlike	ADP	IN	_	_	_	_	_
24	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	seen	see	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9949
# text = Document 0030011989 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011989	0030011989	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9950
# text = Stat6 inhibits human interleukin-4 promoter activity in T cells.
1	Stat6	Stat6	NUM	CD	NumType=Card	_	_	_	_
2	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9951
# text = The differentiation of naive T-helper (Th) cells into cytokine-secreting effector
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Th	th	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	secreting	secreting	NOUN	NN	Number=Sing	_	_	_	_
15	effector	effector	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 9952
# text = Th cells requires exposure to multiple signals, including exogenous cytokines.
1	Th	th	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
10	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9953
# text = Interleukin-4 (IL-4) plays a major role in this process by promoting the differentiation of IL-4-secreting Th2 cells.
1	Interleukin	Interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	process	process	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	secreting	secreting	VERB	VBG	VerbForm=Ger	_	_	_	_
26	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9954
# text = In Th2 cells, IL-4 gene expression is tightly controlled at the level of transcription by the coordinated binding of multiple transcription factors to regulatory elements in the proximal promoter region.
1	In	in	ADP	IN	_	_	_	_	_
2	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	tightly	tightly	ADV	RB	_	_	_	_	_
12	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9955
# text = Nuclear factor of activated T cell (NFAT) family members play a critical role in regulating IL-4 transcription and interact with up to five sequences (termed P0 through P4) in the IL-4 promoter.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	members	member	NOUN	NNS	Number=Plur	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	up	up	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	five	five	NUM	CD	NumType=Card	_	_	_	_
28	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	P0	P0	NUM	CD	NumType=Card	_	_	_	_
32	through	through	ADP	IN	_	_	_	_	_
33	P4	P4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	4	4	NUM	CD	NumType=Card	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9956
# text = The molecular mechanisms by which IL-4 induces expression of the IL-4 gene are not known, although the IL-4-activated transcription factor signal transducer and activator of transcription 6 (Stat6) is required for this effect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	although	although	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
31	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	6	6	NUM	CD	NumType=Card	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	Stat6	stat6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9957
# text = We report here that Stat6 interacts with three binding sites in the human IL-4 promoter by electrophoretic mobility shift assays.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Stat6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9958
# text = These sites overlap the P1, P2, and P4 NFAT elements.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
3	overlap	overlap	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	P1	p1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	P2	p2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	P4	P4	NUM	CD	NumType=Card	_	_	_	_
11	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9959
# text = To investigate the role of Stat6 in regulating IL-4 transcription, we used Stat6-deficient Jurkat T cells with different intact IL-4 promoter constructs in cotransfection assays.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	SCONJ	IN	_	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	Stat6	Stat6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
32	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9960
# text = We show that, whereas a multimerized response element from the germline IgE promoter was highly induced by IL-4 in Stat6-expressing Jurkat cells, the intact human IL-4 promoter was repressed under similar conditions.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	whereas	whereas	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
13	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	highly	highly	ADV	RB	_	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Stat6	Stat6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
26	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	4	4	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	under	under	ADP	IN	_	_	_	_	_
39	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
40	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9961
# text = We conclude that the function of Stat6 is highly dependent on promoter context and that this factor promotes IL-4 gene expression in an indirect manner.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Stat6	stat6	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	highly	highly	ADV	RB	_	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	context	context	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
27	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9962
# text = Document 0030011993 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030011993	0030011993	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9963
# text = Paradoxical priming effects of IL-10 on cytokine production.
1	Paradoxical	Paradoxical	ADJ	JJ	Degree=Pos	_	_	_	_
2	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9964
# text = IL-10 is a well-known immunosuppressive and/or anti-inflammatory cytokine.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	or	or	CCONJ	CC	_	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9965
# text = However, we report in vitro experimental studies in which IL-10 primed leukocytes and led to an enhanced production of tumor necrosis factor (TNF) upon further stimulation by lipopolysaccharide (LPS).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
7	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
8	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	upon	upon	ADP	IN	_	_	_	_	_
30	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9966
# text = Monocytes and peripheral blood mononuclear cells (PBMC) prepared from whole blood maintained for 20
1	Monocytes	Monocyte	PROPN	NNPS	Number=Plur	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	prepared	prepare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	20	20	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 9967
# text = h at 37 degrees C in the presence of recombinant human IL-10 had an enhanced capacity to produce TNF in response to LPS.
1	h	h	INTJ	UH	_	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	37	37	NUM	CD	NumType=Card	_	_	_	_
4	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
21	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9968
# text = In addition to TNF, LPS-induced IL-6 and spontaneous IL-1ra production were also enhanced.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	ra	ra	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9969
# text = When isolated PBMC were first cultured for 20 h in the presence of IL-10 on Teflon to prevent adherence, washed to remove IL-10 and then further cultured in plastic dishes for an additional 20 h in the presence of LPS or IL-1beta, an enhanced release of TNF was observed.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	first	first	ADV	RB	_	_	_	_	_
6	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	_
9	h	h	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
21	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	washed	wash	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	remove	remove	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	then	then	ADV	RB	PronType=Dem	_	_	_	_
31	further	further	ADV	RB	_	_	_	_	_
32	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
35	dishes	dish	NOUN	NNS	Number=Plur	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
39	20	20	NUM	CD	NumType=Card	_	_	_	_
40	h	h	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
46	or	or	CCONJ	CC	_	_	_	_	_
47	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	release	release	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
56	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
57	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9970
# text = This was not the case when PBMC were pre-cultured in plastic multidishes in the presence of IL-10.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	case	case	NOUN	NN	Number=Sing	_	_	_	_
6	when	when	ADV	WRB	PronType=Int	_	_	_	_
7	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	pre-cultured	pre-culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
12	multidishes	multidish	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9971
# text = TNF mRNA expression induced by LPS was decreased when the pre-treatment of PBMC with IL-10 was performed on plastic, whereas this was not the case when cells were pre-cultured with IL-10 on Teflon.
1	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	pre-treatment	pre-treatment	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	10	10	NUM	CD	NumType=Card	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	case	case	NOUN	NN	Number=Sing	_	_	_	_
29	when	when	ADV	WRB	PronType=Int	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	pre-cultured	pre-culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	10	10	NUM	CD	NumType=Card	_	_	_	_
37	on	on	ADP	IN	_	_	_	_	_
38	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9972
# text = Furthermore, NFkappaB translocation following LPS activation was higher after IL-10 pre-treatment on Teflon than on plastic.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
6	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	pre-treatment	pre-treatment	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9973
# text = Interestingly, an enhanced frequency of CD16 and CD68(+) cells among the CD14(+) cells was observed in the presence of IL-10, independently of the pre-culture conditions of the PBMC.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD16	CD16	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD68	Cd68	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	+)	+)	PUNCT	-RRB-	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	among	among	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD14	Cd14	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	+)	+)	PUNCT	-RRB-	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	independently	independently	ADV	RB	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	pre-culture	pre-culture	ADJ	JJ	Degree=Pos	_	_	_	_
33	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9974
# text = Altogether, these results indicate that the IL-10-induced up-regulation of cytokine production depends on the prevention of monocyte adherence by red cells in the whole blood assays or by cultures of PBMC on Teflon.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
25	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
32	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
33	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	Teflon	Teflon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9975
# text = In contrast, the adherence parameter has no effect on the IL-10-induced modulation of some monocyte surface markers.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
6	parameter	parameter	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	_
20	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9976
# text = Document 0030012016 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012016	0030012016	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9977
# text = Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3).
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	FOSB	Fosb	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	G0S3	G0S3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9978
# text = G0S3 is a member of a set of putative G0/G1 switch regulatory genes (G0S genes) selected by screening cDNA libraries prepared from human blood mononuclear cells cultured for 2 hr with lectin and cycloheximide.
1	G0S3	G0S3	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	member	member	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	set	set	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
10	G0/G1	G0/G1	PROPN	NNP	Number=Sing	_	_	_	_
11	switch	switch	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	G0	G0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	S	S	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	screening	scree	VERB	VBG	VerbForm=Ger	_	_	_	_
22	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
23	libraries	library	NOUN	NNS	Number=Plur	_	_	_	_
24	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
28	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9979
# text = The sequence shows high homology with the murine FOSB gene, which encodes a component of the AP1 transcriptional regulator.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
9	FOSB	Fosb	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9980
# text = Comparison of cDNA and genomic sequences reveals a 4-exon structure characteristic of the FOS family of genes.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
7	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
12	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
13	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	FOS	FOS	ADJ	JJ	Degree=Pos	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9981
# text = Freshly isolated cells show high levels of FOSB/G0S3 and FOS/G0S7 mRNAs, which decline rapidly during incubation in culture medium.
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/G0S3	/G0S3	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	FOS	FOS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	/G0S7	/G0S7	NOUN	NN	Number=Sing	_	_	_	_
13	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	decline	decline	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
22	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9982
# text = The kinetics of expression suggest that the high initial levels are caused by the isolation procedure, and do not reflect constitutive expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
16	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	reflect	reflect	VERB	VB	VerbForm=Inf	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9983
# text = In cells preincubated for a day, levels of FOS mRNA reach a maximum 20 min after the addition of lectin and decline to control levels over the next 3 hr.
1	In	in	ADP	IN	_	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	day	day	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	reach	reach	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
15	20	20	NUM	CD	NumType=Card	_	_	_	_
16	min	min	NOUN	NNS	Number=Plur	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	over	over	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	next	next	ADJ	JJ	Degree=Pos	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9984
# text = Levels of FOSB mRNA reach a maximum 40 min after the addition of lectin and decline to control levels over the next 6 hr.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	reach	reach	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	maximum	maximum	NOUN	NN	Number=Sing	_	_	_	_
8	40	40	NUM	CD	NumType=Card	_	_	_	_
9	min	min	NOUN	NNS	Number=Plur	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	over	over	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	next	next	ADJ	JJ	Degree=Pos	_	_	_	_
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9985
# text = In freshly isolated cells, both FOS and FOSB mRNAs increase dramatically in response to the protein synthesis inhibitor cycloheximide.
1	In	in	ADP	IN	_	_	_	_	_
2	freshly	freshly	ADV	RB	_	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNAs	mRNAs	PROPN	NNP	Number=Sing	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	dramatically	dramatically	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9986
# text = In preincubated cells, the cycloheximide response is decreased, especially in the case of FOSB.
1	In	in	ADP	IN	_	_	_	_	_
2	preincubated	preincubate	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	especially	especially	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	case	case	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9987
# text = These differences in expression of FOS and FOSB suggest different roles and regulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	_
9	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9988
# text = Regions of low base order-dependent stem-loop potential in the region of the gene are defined.
1	Regions	region	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
4	base	base	NOUN	NN	Number=Sing	_	_	_	_
5	order	order	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	stem	stem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
11	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9989
# text = These indicate where base order has been adapted for purposes other than stem-loop stability (e.g., encoding proteins or gene regulation).
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	where	where	ADV	WRB	PronType=Int	_	_	_	_
4	base	base	NOUN	NN	Number=Sing	_	_	_	_
5	order	order	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	adapted	adapt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	purposes	purpose	NOUN	NNS	Number=Plur	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	than	than	ADP	IN	_	_	_	_	_
13	stem	stem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
16	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9990
# text = Regions of low potential in a 68.5-kb genomic segment containing the FOSB gene suggest that the potential may help locate genes in uncharted DNA sequences.
1	Regions	region	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
4	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	68.5	68.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
10	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
11	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
12	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	FOSB	FOSB	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
16	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	help	help	VERB	VB	VerbForm=Inf	_	_	_	_
22	locate	locate	VERB	VB	VerbForm=Inf	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	uncharted	uncharted	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 9991
# text = Document 0030012020 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012020	0030012020	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 9992
# text = Transcriptional regulation of the ferritin heavy-chain gene: the activity of the CCAAT binding factor NF-Y is modulated in heme-treated Friend leukemia cells and during monocyte-to-macrophage differentiation.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ferritin	ferritin	ADJ	JJ	Degree=Pos	_	_	_	_
6	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	Y	y	PROPN	NNP	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	heme	heme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	Friend	friend	NOUN	NN	Number=Sing	_	_	_	_
28	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	during	during	ADP	IN	_	_	_	_	_
32	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 9993
# text = The ferritin H-chain gene promoter regulation was analyzed in heme-treated Friend leukemia cells (FLCs) and during monocyte-to-macrophage differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ferritin	ferritin	ADJ	JJ	Degree=Pos	_	_	_	_
3	H-	h-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	heme	heme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	Friend	friend	NOUN	NN	Number=Sing	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	FLCs	FLC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9994
# text = In the majority of cell lines studied, the regulation of ferritin expression was exerted mostly at the translational level.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ferritin	ferritin	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	mostly	mostly	ADV	RB	_	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9995
# text = However, in differentiating erythroid cells, which must incorporate high levels of iron to sustain hemoglobin synthesis, and in macrophages, which are involved in iron storage, transcriptional regulation seemed to be a relevant mechanism.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	SCONJ	IN	_	_	_	_	_
4	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
5	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
10	incorporate	incorporate	VERB	VB	VerbForm=Inf	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	iron	iron	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	sustain	sustain	VERB	VB	VerbForm=Inf	_	_	_	_
17	hemoglobin	hemoglobin	ADP	IN	_	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	iron	iron	ADJ	JJ	Degree=Pos	_	_	_	_
29	storage	storage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	seemed	seem	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
38	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9996
# text = We show here that the minimum region of the ferritin H-gene promoter that is able to confer transcriptional regulation by heme in FLCs to a reporter gene is 77 nucleotides upstream of the TATA box.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	minimum	minimum	NOUN	NN	Number=Sing	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ferritin	ferritin	ADJ	JJ	Degree=Pos	_	_	_	_
11	H-	H-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	heme	heme	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	FLCs	FLC	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	77	77	NUM	CD	NumType=Card	_	_	_	_
31	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
32	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
36	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9997
# text = This cis element binds a protein complex referred to as HRF
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cis	cis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	HRF	HRF	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 9998
# text = (heme-responsive factor), which is greatly enhanced both in heme-treated FLCs and during monocyte-to-macrophage differentiation.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	heme	heme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	greatly	greatly	ADV	RB	_	_	_	_	_
11	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	heme	heme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	FLCs	Flcs	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9999
# text = The CCAAT element present in reverse orientation in this promoter region of the ferritin H-chain gene is necessary for binding and for gene activity, since a single point mutation is able to abolish the binding of HRF and the transcriptional activity in transfected cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CCAAT	CCAAT	NOUN	NN	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
7	orientation	orientation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ferritin	ferritin	ADJ	JJ	Degree=Pos	_	_	_	_
15	H-	H-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	since	since	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
30	point	point	NOUN	NN	Number=Sing	_	_	_	_
31	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	abolish	abolish	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	HRF	HRF	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10000
# text = By competition experiments and supershift assays, we identified the induced HRF as containing at least the ubiquitous transcription factor NF-Y.
1	By	by	ADP	IN	_	_	_	_	_
2	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
6	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	HRF	Hrf	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	at	at	ADV	RB	_	_	_	_	_
16	least	least	ADV	RBS	Degree=Sup	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Y.	Y.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 10001
# text = NF-Y is formed by three subunits, A, B, and C, all of which are necessary for DNA binding.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Y	y	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	all	all	DET	DT	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	SCONJ	IN	_	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10002
# text = Cotransfection with a transdominant negative mutant of the NF-YA subunit abolishes the transcriptional activation by heme, indicating that NF-Y plays an essential role in this activation.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transdominant	transdominant	ADJ	JJ	Degree=Pos	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	YA	ya	PROPN	NNP	Number=Sing	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	heme	heme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Y	y	PROPN	NNP	Number=Sing	_	_	_	_
25	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10003
# text = We have also observed a differential expression of the NF-YA subunit in heme-treated and control FLCs and during monocyte-to-macrophage differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	YA	ya	PROPN	NNP	Number=Sing	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	heme	heme	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
20	FLCs	FLC	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10004
# text = Document 0030012022 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012022	0030012022	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10005
# text = Biphasic control of NF-kappa B activation induced by the triggering of HLA-DR antigens expressed on B cells.
1	Biphasic	Biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
17	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10006
# text = The regulation of NF-kappa B activation following the triggering of HLA-DR antigens by mAb L243 has been studied at various times in Raji cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
16	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
19	L243	L243	NOUN	NN	Number=Sing	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
25	times	time	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10007
# text = Electrophoretic mobility shift assays demonstrated a strong increase of NF-kappa B DNA binding after triggering of HLA-DR antigens.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	ADV	RB	_	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	after	after	SCONJ	IN	_	_	_	_	_
17	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
22	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10008
# text = Using TNF-alpha-activity neutralizing antibodies, the authors demonstrated that the upregulation of NF-kappa B was found to depend, at later time point, on an autocrine effect of TNF-alpha secreted following triggering of HLA-DR antigens.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	alpha-activity	alpha-activity	NOUN	NN	Number=Sing	_	_	_	_
5	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
6	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	authors	author	NOUN	NNS	Number=Plur	_	_	_	_
10	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	later	later	ADV	RB	_	_	_	_	_
26	time	time	NOUN	NN	Number=Sing	_	_	_	_
27	point	point	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	autocrine	autocrine	ADJ	JJ	Degree=Pos	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	alpha	alpha	ADV	RB	_	_	_	_	_
37	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
39	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
44	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10009
# text = In contrast, it was found to be TNF-alpha independent in the early time point.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	alpha	alpha	ADV	RB	_	_	_	_	_
12	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	time	time	NOUN	NN	Number=Sing	_	_	_	_
17	point	point	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10010
# text = Moreover, the upregulation of NF-kappa B binding activity is regulated by the triggering of selected epitopes of HLA-DR antigens.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
24	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10011
# text = In fact, mAb L243 but not the staphylococcal superantigens, staphylococcal exotoxin toxic shock syndrome toxin-I or staphylococcal enterotoxin B, regulate the NF-kappa B binding activity.
1	In	in	ADP	IN	_	_	_	_	_
2	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
5	L243	L243	NUM	CD	NumType=Card	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
10	superantigens	superantigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
13	exotoxin	exotoxin	ADP	IN	_	_	_	_	_
14	toxic	toxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
16	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
17	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
22	enterotoxin	enterotoxin	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10012
# text = Document 0030012023 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012023	0030012023	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10013
# text = Tissue-specific regulation of the ecto-5'-nucleotidase promoter.
1	Tissue-	Tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ecto	ecto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
10	nucleotidase	nucleotidase	NOUN	NN	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10014
# text = Role of the camp response element site in mediating repression by the upstream regulatory region.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	camp	camp	NOUN	NN	Number=Sing	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10015
# text = We have isolated the 5' region of the ecto-5'-nucleotidase (low K(m)
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	'	PUNCT	``	_	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ecto	ecto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
14	nucleotidase	nucleotidase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	K	K	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	m	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 10016
# text = 5'-NT) gene and established that a 969-base pair (bp) fragment confers cell-specific expression of a CAT reporter gene that correlates with the expression of endogenous ecto-5'-NT mRNA and enzymatic activity.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	NT	not	PART	RB	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	established	establish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	969	969	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	base	base	NOUN	NN	Number=Sing	_	_	_	_
14	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
19	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
36	ecto	ecto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-5	-5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	NT	not	PROPN	NNP	Number=Sing	_	_	_	_
41	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	enzymatic	enzymatic	ADJ	JJ	Degree=Pos	_	_	_	_
44	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10017
# text = A 768-bp upstream negative regulatory region has been identified that conferred lymphocyte-specific negative regulation in a heterologous system with a 244-bp deoxycytidine kinase core promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	768	768	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	244	244	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	deoxycytidine	deoxycytidine	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	core	core	NOUN	NN	Number=Sing	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10018
# text = DNase I footprinting identified several protected areas including Sp1, Sp1/AP-2, and cAMP response element (CRE) binding sites within the 201-bp core promoter region and Sp1, NRE-2a, TCF-1/LEF-1, and Sp1/NF-AT binding sites in the upstream regulatory region.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	footprinting	footprint	AUX	VBG	VerbForm=Ger	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	areas	area	NOUN	NNS	Number=Plur	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Sp1/AP	sp1/Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	within	within	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	201	201	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
29	core	core	NOUN	NN	Number=Sing	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-2a	-2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1/LEF	1/LEF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	Sp1/NF	Sp1/NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	AT	at	SCONJ	IN	_	_	_	_	_
48	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
49	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
53	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
54	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10019
# text = Whereas the CRE site was essential in mediating the negative activity of the upstream regulatory region in Jurkat but not in HeLa cells, mutation of the Sp1/AP-2 site decreased promoter activity in both cell lines.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	SCONJ	IN	_	_	_	_	_
8	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Sp1/AP	sp1/Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	both	both	DET	DT	_	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10020
# text = Electrophoretic mobility shift assay analysis of proteins binding to the CRE site identified both ATF-1 and ATF-2 in Jurkat cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	ATF	ATF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	ATF	ATF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10021
# text = Finally, phorbol 12-myristate 13-acetate increased the activity of both the core and the 969-bp promoter fragments, and this increase was abrogated by mutations at the CRE site.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
4	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
7	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	core	core	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	969	969	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10022
# text = In summary, we have identified a tissue-specific regulatory region 5' of the ecto-5'-NT core promoter that requires the presence of a functional CRE site within the basal promoter for its suppressive activity.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	ecto	ecto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	NT	not	ADJ	JJ	Degree=Pos	_	_	_	_
23	core	core	NOUN	NN	Number=Sing	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
32	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	within	within	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10023
# text = Document 0030012031 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012031	0030012031	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10024
# text = Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc [published erratum appears in J Biol Chem 1996 Dec 27;271(52):33705]
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	member	member	NOUN	NN	Number=Sing	_	_	_	_
20	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
24	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	J	j	PROPN	NNP	Number=Sing	_	_	_	_
27	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
28	Chem	Chem	PROPN	NNP	Number=Sing	_	_	_	_
29	1996	1996	NUM	CD	NumType=Card	_	_	_	_
30	Dec	Dec	PROPN	NNP	Number=Sing	_	_	_	_
31	27;271	27;271	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	52)	52)	SYM	NFP	_	_	_	_	SpaceAfter=No
34	:33705	:33705	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10025
# text = The cyclosporin A (CsA)/FK506-sensitive nuclear factor of activated T cells (NFAT) plays a key role in the inducible expression of cytokine genes in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
3	A	a	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	/FK506	/FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-sensitive	-sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10026
# text = Although NFAT has been recently shown to be inducible in several non-T immune cells, the NFAT gene family members characterized to date have been isolated only from T cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	recently	recently	ADV	RB	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	non-T	non-t	ADJ	JJ	Degree=Pos	_	_	_	_
13	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	date	date	NOUN	NN	Number=Sing	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	T	T	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10027
# text = To further characterize NFAT function in human B cells and to demonstrate cytokine gene specificity of NFAT proteins, we report here the isolation and characterization of a cDNA clone from the Raji B cell line.
1	To	to	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	characterize	characterize	NOUN	NN	Number=Sing	_	_	_	_
4	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	here	here	ADV	RB	PronType=Dem	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
30	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10028
# text = The cDNA clone encodes a new isoform, NFATc.beta, of the NFAT gene family member NFATc (designated here NFATc.alpha).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
7	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	member	member	NOUN	NN	Number=Sing	_	_	_	_
17	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	here	here	ADV	RB	PronType=Dem	_	_	_	_
21	NFATc.alpha	NFATc.alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10029
# text = The amino acid sequence of NFATc.beta differs from that of NFATc.alpha in the first NH2-terminal 29 residues and contains an additional region of 142 residues at the COOH terminus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	amino	amino	DET	DT	_	_	_	_	_
3	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	_
7	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NFATc.alpha	NFATc.alpha	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
15	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	29	29	NUM	CD	NumType=Card	_	_	_	_
19	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	142	142	NUM	CD	NumType=Card	_	_	_	_
27	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	COOH	COOH	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
31	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10030
# text = Northern analysis using a probe encompassing a common region of both isoforms showed two mRNA species of 2.7 and 4.5 kilobase pairs, while an NFATc.beta-specific probe detected only the 4.5-kilobase pair mRNA which was preferentially expressed in the spleen.
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
6	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
13	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	species	species	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	2.7	2.7	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	4.5	4.5	NUM	CD	NumType=Card	_	_	_	_
21	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
22	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	while	while	SCONJ	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	4.5	4.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
36	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
37	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	preferentially	preferentially	ADV	RB	_	_	_	_	_
41	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10031
# text = Transient expression of NFATc.beta was capable of activating an interleukin-2 NFAT-driven reporter gene in stimulated Jurkat cells in a CsA-sensitive manner.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	SCONJ	IN	_	_	_	_	_
8	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	stimulated	stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
27	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10032
# text = However, NFATc.beta neither bound to the kappa3 element ( an NFAT-binding site ) in the tumor necrosis factor-alpha promoter nor activated the tumor necrosis factor-alpha promoter in cotransfection assays.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NFATc.beta	NFATc.beta	PROPN	NNP	Number=Sing	_	_	_	_
4	neither	neither	DET	DT	_	_	_	_	_
5	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	kappa3	kappa3	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	nor	nor	CCONJ	CC	_	_	_	_	_
26	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
36	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10033
# text = These data suggest that different members or isoforms of NFAT gene family may regulate inducible expression of different cytokine genes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	members	member	NOUN	NNS	Number=Plur	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10034
# text = Document 0030012032 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012032	0030012032	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10035
# text = Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor-kappaB	factor-kappab	NOUN	NN	Number=Sing	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	dermal	dermal	ADJ	JJ	Degree=Pos	_	_	_	_
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10036
# text = Bacterial lipopolysaccharide (LPS)-mediated immune responses, including activation of monocytes, macrophages, and endothelial cells, play an important role in the pathogenesis of Gram-negative bacteria-induced sepsis syndrome.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
9	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	play	play	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	Gram-	Gram-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
32	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	sepsis	sepsis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
36	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10037
# text = Activation of NF-kappaB is thought to be required for cytokine release from LPS-responsive cells, a critical step for endotoxic effects.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	release	release	NOUN	NN	Number=Sing	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
22	step	step	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	endotoxic	endotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
25	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10038
# text = Here we investigated the role and involvement of interleukin-1 (IL-1) and tumor necrosis factor (TNF-alpha) signal transducer molecules in LPS signaling in human dermal microvessel endothelial cells (HDMEC) and THP-1 monocytic cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
19	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
27	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
28	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
31	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	dermal	dermal	ADJ	JJ	Degree=Pos	_	_	_	_
35	microvessel	microvessel	NOUN	NN	Number=Sing	_	_	_	_
36	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	HDMEC	HDMEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10039
# text = LPS stimulation of HDMEC and THP-1 cells initiated an IL-1 receptor-like NF-kappaB signaling cascade.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HDMEC	Hdmec	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	like	like	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
22	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10040
# text = In transient cotransfection experiments, dominant negative mutants of the IL-1 signaling pathway, including MyD88, IRAK, IRAK2, and TRAF6 inhibited both IL-1- and LPS-induced NF-kappaB-luciferase activity.
1	In	in	ADP	IN	_	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
3	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	MyD88	MyD88	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	IRAK2	Irak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	TRAF6	TRAF6	PROPN	NNP	Number=Sing	_	_	_	_
26	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10041
# text = LPS-induced NF-kappaB activation was not inhibited by a dominant negative mutant of TRAF2 that is involved in TNF signaling.
1	LPS	Lps	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	TNF	Tnf	ADJ	JJ	Degree=Pos	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10042
# text = LPS-induced activation of NF-kappaB-responsive reporter gene was not inhibited by IL-1 receptor antagonist.
1	LPS	Lps	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10043
# text = TLR2 and TLR4 were expressed on the cell surface of HDMEC and THP-1 cells.
1	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	TLR4	TLR4	NUM	CD	NumType=Card	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	HDMEC	Hdmec	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10044
# text = These findings suggest that a signal transduction molecule in the LPS receptor complex may belong to the IL-1 receptor/toll-like receptor (TLR) super family, and the LPS signaling cascade uses an analogous molecular framework for signaling as IL-1 in mononuclear phagocytes and endothelial cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
7	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
8	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	LPS	LPS	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	belong	belong	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	toll	toll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	TLR	Tlr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	super	super	ADV	RB	_	_	_	_	_
31	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
36	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
37	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
38	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
41	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
42	framework	framework	NOUN	NN	Number=Sing	_	_	_	_
43	for	for	SCONJ	IN	_	_	_	_	_
44	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
45	as	as	ADP	IN	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
51	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10045
# text = Document 0030012035 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012035	0030012035	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10046
# text = The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	toll	toll	NOUN	NN	Number=Sing	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	divergence	divergence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	SAPK	SAPK	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	TRAF6	TRAF6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10047
# text = The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
6	Toll	toll	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	hToll	hToll	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	cloned	cloned	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1R	1R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	superfamily	superfamily	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	adaptive	adaptive	ADJ	JJ	Degree=Pos	_	_	_	_
36	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10048
# text = Signaling by hToll is shown to occur through sequential recruitment of the adapter molecule MyD88 and the IL-1R-associated kinase.
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	hToll	hToll	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	sequential	sequential	ADJ	JJ	Degree=Pos	_	_	_	_
10	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	adapter	adapter	NOUN	NN	Number=Sing	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
15	MyD88	Myd88	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL-	Il-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	1R-	1R-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10049
# text = Tumor necrosis factor receptor-activated factor 6 (TRAF6) and the nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) are both involved in subsequent steps of NF-kappaB activation.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TRAF6	Traf6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	both	both	ADV	RB	_	_	_	_	_
29	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
32	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10050
# text = Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	version	version	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
9	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
12	hToll	hToll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	kinase/	kinase/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
25	NH2	Nh2	PART	TO	Abbr=Yes	_	_	_	SpaceAfter=No
26	-terminal	-terminal	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	thus	thus	ADV	RB	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
33	divergence	divergence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	two	two	NUM	CD	NumType=Card	_	_	_	_
37	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10051
# text = Document 0030012037 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012037	0030012037	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10052
# text = Cell specific expression of human Bruton's agammaglobulinemia tyrosine kinase gene (Btk) is regulated by Sp1- and Spi-1/PU.1-family members.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	Bruton	Bruton	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	's	's	PART	POS	_	_	_	_	_
8	agammaglobulinemia	agammaglobulinemia	NOUN	NN	Number=Sing	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Btk	Btk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Spi-1/	spi-1/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10053
# text = Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase involved in the human disease X-linked agammaglobulinemia (XLA).
1	Bruton	Bruton	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	's	's	PART	POS	_	_	_	_	_
3	agammaglobulinemia	agammaglobulinemia	NOUN	NN	Number=Sing	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	Btk	Btk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
19	X	x	SYM	SYM	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	agammaglobulinemia	agammaglobulinemia	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	XLA	XLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10054
# text = The gene is expressed in all hematopoietic cells with the exception of T-cells and plasma cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10055
# text = For this expression pattern the first 280 bp upstream of the major transcriptional start site seems to be sufficient.
1	For	for	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	pattern	pattern	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	280	280	NUM	CD	NumType=Card	_	_	_	_
8	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
9	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	start	start	NOUN	NN	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10056
# text = In vitro footprinting analysis within this part of the promoter revealed two Sp1 binding sites as well as a PU-box.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	part	part	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	PU-	Pu-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10057
# text = The transcription factor Spi-1/PU.1 as well as the closely related factor Spi-B bound to the PU-box in B-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	Spi-1	Spi-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	PU	Pu	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.1	.1	NUM	CD	NumType=Card	_	_	_	_
8	as	as	ADV	RB	_	_	_	_	_
9	well	well	ADV	RB	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	closely	closely	ADV	RB	_	_	_	_	_
13	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	Spi	Spi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	PU	PU	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	box	box	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10058
# text = In the erythroleukemia cell line K562, due to the absence of Spi-B, only PU.1 bound to the Btk promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	line	line	NOUN	NN	Number=Sing	_	_	_	_
6	K562	K562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	due	due	ADP	IN	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	only	only	ADV	RB	_	_	_	_	_
18	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
19	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Btk	Btk	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10059
# text = Mutation of either site reduced the expression in transient transfection experiments.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	either	either	DET	DT	_	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
10	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
11	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10060
# text = However, mutation of the PU box had no effect in the T-cell line Jurkat, where none of the Spi-1 family members is expressed.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PU	PU	PROPN	NNP	Number=Sing	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	where	where	ADV	WRB	PronType=Rel	_	_	_	_
19	none	none	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10061
# text = In addition Spi-B as well as PU.1 were able to transactivate Btk expression.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	Spi	Spi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	as	as	ADV	RB	_	_	_	_	_
7	well	well	ADV	RB	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
14	Btk	Btk	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10062
# text = In fetal liver of PU.1-/- mice, which lack lymphoid and myeloid cells, expression of Btk was reduced two- to threefold but not abolished.
1	In	in	ADP	IN	_	_	_	_	_
2	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
3	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	/-	/-	PUNCT	.	_	_	_	_	_
8	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Btk	Btk	PROPN	NNP	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	threefold	threefold	VERB	VB	VerbForm=Inf	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10063
# text = Collectively this study shows that expression of the Btk gene is regulated by the combined action of Sp1- and PU.1-family members.
1	Collectively	collectively	ADV	RB	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Btk	Btk	PROPN	NNP	Number=Sing	_	_	_	_
10	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	action	action	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10064
# text = Document 0030012047 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012047	0030012047	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10065
# text = Activation of nuclear factor kappa B in human neuroblastoma cell lines.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10066
# text = The nuclear factor kappa B (NF-kappa B) is a eukaryotic transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10067
# text = In B cells and macrophages it is constitutively present in cell nuclei, whereas in many other cell types, NF-kappa B translocates from cytosol to nucleus as a result of transduction by tumor necrosis factor alpha (TNF alpha), phorbol ester, and other polyclonal signals.
1	In	in	ADP	IN	_	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	translocates	translocate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	nucleus	nucleus	VERB	VB	VerbForm=Inf	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	result	result	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
46	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
50	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
51	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10068
# text = Using neuroblastoma cell lines as models, we have shown that in neural cells NF-kappa B was present in the cytosol and translocated into nuclei as a result of TNF alpha treatment.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	neural	neural	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	into	into	ADP	IN	_	_	_	_	_
27	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	result	result	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
33	alpha	alpha	ADP	IN	_	_	_	_	_
34	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10069
# text = The TNF alpha-activated NF-kappa B was transcriptionally functional.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
3	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10070
# text = NF-kappa B activation by TNF alpha was not correlated with cell differentiation or proliferation.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10071
# text = However, reagents such as nerve growth factor (NGF) and the phorbol ester phorbol 12-myristate 13-acetate (PMA), which induce phenotypical differentiation of the SH-SY5Y neuroblastoma cell line, activated NF-kappa B, but only in that particular cell line.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	reagents	reagent	NOUN	NNS	Number=Plur	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	nerve	nerve	ADJ	JJ	Degree=Pos	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	NGF	NGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
20	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
22	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	phenotypical	phenotypical	ADJ	JJ	Degree=Pos	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	SH	Sh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	SY5Y	SY5y	NOUN	NN	Number=Sing	_	_	_	_
36	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
44	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	but	but	CCONJ	CC	_	_	_	_	_
47	only	only	ADV	RB	_	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
50	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10072
# text = In a NGF-responsive rat pheochromocytoma cell line, PC12, PMA activated NF-kappa B, whereas NGF did not.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	NGF	NGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
6	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
7	pheochromocytoma	pheochromocytoma	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	PC12	Pc12	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	whereas	whereas	SCONJ	IN	_	_	_	_	_
21	NGF	NGF	PROPN	NNP	Number=Sing	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10073
# text = In other neuroblastoma cell lines, such as SK-N-Be(2), the lack of PMA induction of differentiation was correlated with the lack of NF-kappa B activation.
1	In	in	ADP	IN	_	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	SK	SK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Be	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10074
# text = We found, moreover, that in SK-N-Be(2) cells protein kinase C (PKC) enzymatic activity was much lower compared with that in a control cell line and that the low PKC enzymatic activity was due to low PKC protein expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	SK	SK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Be	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	C	C	PROPN	NNP	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	enzymatic	enzymatic	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	much	much	ADV	RB	_	_	_	_	_
27	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	control	control	NOUN	NN	Number=Sing	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	line	line	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
40	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
41	enzymatic	enzymatic	ADJ	JJ	Degree=Pos	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
44	due	due	ADP	IN	_	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
47	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10075
# text = NF-kappa B was not activated by retinoic acid, which induced morphological differentiation of all the neuroblastoma cell lines used in the present study.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	all	all	DET	PDT	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
22	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
26	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10076
# text = Thus, NF-kappa B activation was not required for neuroblastoma cell differentiation.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10077
# text = Furthermore, the results obtained with TNF alpha proved that NF-kappa B activation was not sufficient for induction of neuroblastoma differentiation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	ADV	RB	_	_	_	_	_
9	proved	prove	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	neuroblastoma	neuroblastoma	NOUN	NN	Number=Sing	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10078
# text = Document 0030012050 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012050	0030012050	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10079
# text = Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
7	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10080
# text = NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	tat	tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	product	product	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10081
# text = To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	members	member	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	abilities	abilitie	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	subunits	subunit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
43	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10082
# text = We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	together	together	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
34	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10083
# text = Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells.
1	Little	little	ADJ	JJ	Degree=Pos	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	p105	p105	NUM	CD	NumType=Card	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	p65	p65	NUM	CD	NumType=Card	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	length	length	NOUN	NN	Number=Sing	_	_	_	_
27	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10084
# text = These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	tat	tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	product	product	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
35	RNA.	RNA.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10085
# text = Document 0030012057 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012057	0030012057	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10086
# text = Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist.
1	Cobalt	Cobal	PROPN	NNP	Number=Sing	_	_	_	_
2	chloride	chloride	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
8	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
15	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
20	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
25	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	60	60	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10087
# text = In response to hypoxia, sickle red blood cells (SS RBC) and leukocytes exhibit increased adherence to the vascular endothelium, while diapedesis of leukocytes through the blood vessel increases.
1	In	in	ADP	IN	_	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	hypoxia	hypoxia	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	sickle	sickle	ADJ	JJ	Degree=Pos	_	_	_	_
7	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	SS	Ss	PROPN	NNP	Number=Sing	_	_	_	_
12	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	exhibit	exhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
22	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	while	while	SCONJ	IN	_	_	_	_	_
25	diapedesis	diapedesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
31	vessel	vessel	NOUN	NN	Number=Sing	_	_	_	_
32	increases	increase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10088
# text = However, the cellular signaling pathway(s) caused by hypoxia is poorly understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	poorly	poorly	ADV	RB	_	_	_	_	_
15	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10089
# text = We utilized CoCl2 as a mimetic molecule for hypoxia to study cellular signaling pathways.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	utilized	utilize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	CoCl2	CoCl2	NUM	CD	NumType=Card	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	mimetic	mimetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
12	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
13	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10090
# text = We found that in human umbilical vein endothelial cells (HUVEC), CoCl2 at 2 mM concentration induced the surface expression of a subset of CAMs (VCAM-1) and activation of transcription factor NF-kappaB in the nuclear extracts of HUVEC.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
7	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CoCl2	CoCl2	NUM	CD	NumType=Card	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	mM	mm	PROPN	NNP	Number=Sing	_	_	_	_
18	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	CAMs	Cams	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	VCAM	VCAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10091
# text = Furthermore, CoCl2 also caused time-dependent tyrosine phosphorylation of mitogen-activated protein (MAP) kinase isoform ERK2 without significantly affecting ERK1, indicating ERK2 is the preferred substrate for upstream kinase of the MAPK pathway.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CoCl2	CoCl2	PART	TO	Abbr=Yes	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
21	ERK2	Erk2	NOUN	NN	Number=Sing	_	_	_	_
22	without	without	SCONJ	IN	_	_	_	_	_
23	significantly	significantly	ADV	RB	_	_	_	_	_
24	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
25	ERK1	ERK1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	ERK2	ERK2	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	preferred	preferred	ADJ	JJ	Degree=Pos	_	_	_	_
32	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
35	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
39	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10092
# text = Inhibitors of MAP kinase (PD98059) or platelet-activating factor (PAF)- receptor antagonist (CV3988) inhibited the CoCl2-induced NF-kappaB activation and VCAM-1 expression.
1	Inhibitors	Inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PD98059	PD98059	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PAF	PAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	CV3988	CV3988	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	CoCl2	Cocl2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10093
# text = Augmented expression of VCAM-1 led to increased SS RBC adhesion, inhibitable by a VCAM-1 antibody.
1	Augmented	Augmented	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	increased	increase	VERB	VB	VerbForm=Inf	_	_	_	_
10	SS	SS	PROPN	NNP	Number=Sing	_	_	_	_
11	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	inhibitable	inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10094
# text = Additionally, CoCl2 caused a two- to threefold increase in the rate of transendothelial migration of monocyte-like HL-60 cells and a twentyfold increase in phosphorylation of platelet endothelial cell adhesion molecules (PECAM-1).
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CoCl2	CoCl2	PART	TO	Abbr=Yes	_	_	_	_
4	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	threefold	threefold	VERB	VB	VerbForm=Inf	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
21	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	60	60	NUM	CD	NumType=Card	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	twentyfold	twentyfold	NOUN	NN	Number=Sing	_	_	_	_
28	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
33	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10095
# text = The transendothelial migration of monocytes was inhibited by an antibody to PECAM-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	PECAM	PECAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10096
# text = Both phosphorylation of PECAM-1 and transendothelial migration of monocytes in response to CoCl2 were inhibited by protein kinase inhibitor (GF109203X) and augmented by protein phosphatase inhibitor (Calyculin
1	Both	both	DET	DT	_	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PECAM	PECAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	CoCl2	CoCl2	NUM	CD	NumType=Card	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GF109203X	GF109203X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
30	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Calyculin	Calyculin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 10097
# text = A).
1	A	A	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10098
# text = Our data suggests that CoCl2-induced cellular signals directing increased expression of VCAM-1 in HUVEC involve downstream activation of MAP kinase and NF-kappaB, while the phosphorylation of PECAM-1 occurs as a result of activation of PKC.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	CoCl2	Cocl2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
10	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
19	involve	involve	ADJ	JJ	Degree=Pos	_	_	_	_
20	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	while	while	SCONJ	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	PECAM	PECAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	result	result	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10099
# text = We conclude that PAF-receptor antagonist inhibits the CoCl2- or hypoxia-induced increase in the adhesion of SS RBC, PECAM-1 phosphorylation, and the concomitant transendothelial migration of monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	PAF	Paf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
8	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CoCl2	Cocl2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	SS	SS	PROPN	NNP	Number=Sing	_	_	_	_
22	RBC	RBC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	PECAM	PECAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
32	transendothelial	transendothelial	ADJ	JJ	Degree=Pos	_	_	_	_
33	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10100
# text = Document 0030012061 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012061	0030012061	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10101
# text = Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation.
1	Tap	tap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	tip	tip	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
13	saimiri	saimirus	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
16	lymphocyte	lymphocyte	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10102
# text = Tip of herpesvirus saimiri associates with Lck and down-regulates Lck-mediated activation.
1	Tip	tip	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
4	saimiri	saimiri	NOUN	NN	Number=Sing	_	_	_	_
5	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	Lck-mediated	Lck-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10103
# text = We identified a novel cellular Tip-associated protein (Tap) by a yeast two-hybrid screen.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
6	Tip	tip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Tap	tap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
18	screen	screen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10104
# text = Tap associated with Tip following transient expression in COS-1 cells and stable expression in human Jurkat-T cells.
1	Tap	tap	NOUN	NN	Number=Sing	_	_	_	_
2	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	Tip	tip	PROPN	NNP	Number=Sing	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
6	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10105
# text = Expression of Tip and Tap in Jurkat-T cells induced dramatic cell aggregation.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Tip	tip	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Tap	tap	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10106
# text = Aggregation was likely caused by the up-regulated surface expression of adhesion molecules including integrin alpha, L-selectin, ICAM-3, and H-CAM.
1	Aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	likely	likely	ADV	RB	_	_	_	_	_
4	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	integrin	integrin	ADP	IN	_	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	L-selectin	L-selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	ICAM	ICAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CAM	CAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10107
# text = Furthermore, NF-kappaB transcriptional factor of aggregated cells had approximately 40-fold higher activity than that of parental cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	aggregated	aggregated	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
16	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10108
# text = Thus, Tap is likely to be an important cellular mediator of Tip function in T cell transformation by herpesvirus saimiri.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tap	tap	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Tip	tip	NOUN	NN	Number=Sing	_	_	_	_
14	function	function	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
21	saimiri	saimiri	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10109
# text = Document 0030012064 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012064	0030012064	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10110
# text = Cell-type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/JUN.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	type-specific	type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	ADP	IN	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	JUN	JUN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10111
# text = The human tumor necrosis factor alpha (TNF-alpha) gene is one of the earliest genes transcribed after the stimulation of a B cell through its antigen receptor or via the CD-40 pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	via	via	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	40	40	NUM	CD	NumType=Card	_	_	_	_
37	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10112
# text = In both cases, induction of TNF-alpha gene transcription can be blocked by the immunosuppressants cyclosporin A and FK506, which suggested a role for the NFAT family of proteins in the regulation of the gene in B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
18	cyclosporin	cyclosporin	ADP	IN	_	_	_	_	_
19	A	a	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10113
# text = Furthermore, in T cells, two molecules of NFATp bind to the TNF-alpha promoter element kappa 3 in association with ATF-2 and Jun proteins bound to an immediately adjacent cyclic AMP response element (CRE) site.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
11	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	association	association	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	immediately	immediately	ADV	RB	_	_	_	_	_
34	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
35	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
36	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
37	response	response	NOUN	NN	Number=Sing	_	_	_	_
38	element	element	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	CRE	CRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10114
# text = Here, using the murine B-cell lymphoma cell line A20, we show that the TNF-alpha gene is regulated in a cell-type-specific manner.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	A20	A20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10115
# text = In A20 B cells, the TNF-alpha gene is not regulated by NFATp bound to the kappa 3 element.
1	In	in	ADP	IN	_	_	_	_	_
2	A20	A20	NUM	CD	NumType=Card	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10116
# text = Instead, ATF-2 and Jun proteins bind to the composite kappa 3/CRE site and NFATp binds to a newly identified second NFAT site centered at -76 nucleotides relative to the TNF-alpha transcription start site.
1	Instead	instead	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	composite	composite	NOUN	NN	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	3/CRE	3/cre	NOUN	NN	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	_
18	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	newly	newly	ADV	RB	_	_	_	_	_
22	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
24	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	76	76	NUM	CD	NumType=Card	_	_	_	_
30	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
31	relative	relative	ADV	RB	_	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	start	start	NOUN	NN	Number=Sing	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10117
# text = This new site plays a critical role in the calcium-mediated, cyclosporin A-sensitive induction of TNF-alpha in both A20 B cells and Ar-5 cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	calcium-	calcium-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	A20	A20	NUM	CD	NumType=Card	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Ar	ar	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	5	5	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10118
# text = Consistent with these results, quantitative DNase footprinting of the TNF-alpha promoter using increasing amounts of recombinant NFATp demonstrated that the -76 site binds to NFATp with a higher affinity than the kappa 3 site.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
8	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
17	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
20	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
21	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	76	76	NUM	CD	NumType=Card	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	_
27	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	NFATp	NFATp	VERB	VB	VerbForm=Inf	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
33	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
34	than	than	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	3	3	NUM	CD	NumType=Card	_	_	_	_
38	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10119
# text = Two other previously unrecognized NFATp-binding sites in the proximal TNF-alpha promoter were also identified by this analysis.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	unrecognized	unrecognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10120
# text = Thus, through the differential use of the same promoter element, the composite kappa 3/CRE site, the TNF-alpha gene is regulated in a cell-type-specific manner in response to the same extracellular signal.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
6	use	use	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	3/CRE	3/cre	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	type-specific	type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
37	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
38	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10121
# text = Document 0030012069 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012069	0030012069	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10122
# text = Regulation of human epsilon germline transcription: role of B-cell-specific activator protein.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
5	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10123
# text = Germline transcripts initiate from promoters upstream of the immunoglobulin switch region, and are necessary to target the appropriate switch region for recombination and switching.
1	Germline	Germline	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	initiate	initiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
6	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
10	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
20	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	switching	switch	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10124
# text = Different cytokines activate transcription at the appropriate germline promoter.
1	Different	different	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
8	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10125
# text = Because binding sites for B-cell-specific activator protein (BSAP) are located upstream of several switch regions in the immunoglobulin heavy chain gene cluster, BSAP might play a role in the regulation of germline transcription and isotype switching.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	BSAP	Bsap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
19	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
20	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
24	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
25	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	_
30	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
31	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	role	role	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
42	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10126
# text = We investigated whether BSAP plays a role in the transcriptional regulation of the epsilon germline promoter in human B cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
5	plays	plays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
15	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10127
# text = Our results showed that BSAP plays a role in both IL-4-dependent induction and CD40-mediated upregulation of human epsilon germline transcription.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
6	plays	plays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
25	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10128
# text = BSAP is unique among the transcription factors that regulate epsilon germline expression, because it is B cell specific, and is at the merging point of two signalling pathways that are critical for IgE switching.
1	BSAP	Bsap	SYM	NFP	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
4	among	among	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	epsilon	epsilon	ADP	IN	_	_	_	_	_
11	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	because	because	SCONJ	IN	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	merging	merging	NOUN	NN	Number=Sing	_	_	_	_
26	point	point	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
30	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	SCONJ	IN	_	_	_	_	_
35	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	_
36	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10129
# text = Document 0030012079 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012079	0030012079	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10130
# text = Activation of the human delta-globin gene promoter in primary adult erythroid cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	delta	delta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
12	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10131
# text = Restoration of the CCAAT box or insertion of an erythroid Kruppel-like factor (EKLF) binding site in the delta promoter activates its expression in several erythroid cell lines.
1	Restoration	restoration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
5	box	box	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
29	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10132
# text = We extended these studies using a novel primary human adult erythroid cell (hAEC) system to investigate these effects at the late erythroblast stage.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	extended	extend	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
11	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	hAEC	hAEC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	system	system	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
24	erythroblast	erythroblast	ADJ	JJ	Degree=Pos	_	_	_	_
25	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10133
# text = Restoration of the CCAAT box at -70 bp, or insertion of an EKLF binding site at -85 bp or -95 bp in the promoter significantly increased delta globin gene expression in hAEC.
1	Restoration	restoration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CCAAT	Ccaat	PROPN	NNP	Number=Sing	_	_	_	_
5	box	box	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	70	70	NUM	CD	NumType=Card	_	_	_	_
9	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	85	85	NUM	CD	NumType=Card	_	_	_	_
21	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	95	95	NUM	CD	NumType=Card	_	_	_	_
25	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	significantly	significantly	ADV	RB	_	_	_	_	_
30	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
32	globin	globin	ADP	IN	_	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	hAEC	hAEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10134
# text = Our results demonstrate that the altered CCAAT box (CCAAC) and the lack of an EKLF binding site in delta-globin contribute to its low level of expression in the hAEC model as well.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	CCAAC	CCAAC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	delta	delta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
24	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
28	level	level	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	hAEC	hAEC	PROPN	NNP	Number=Sing	_	_	_	_
34	model	model	NOUN	NN	Number=Sing	_	_	_	_
35	as	as	ADV	RB	_	_	_	_	_
36	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10135
# text = Document 0030012083 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012083	0030012083	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10136
# text = Induction of a functional vitamin D receptor in all-trans-retinoic acid-induced monocytic differentiation of M2-type leukemic blast cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
6	D	would	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
14	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	M2	m2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
24	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10137
# text = Different types of acute myeloid leukemia blast cells were induced to differentiate in vitro with all-trans-retinoic acid (ATRA) and vitamin D3 (VD).
1	Different	different	ADJ	JJ	Degree=Pos	_	_	_	_
2	types	type	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
5	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
6	leukemia	leukemia	ADP	IN	_	_	_	_	_
7	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ATRA	ATRA	X	AFX	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
27	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	VD	VD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10138
# text = M0/M1 leukemic cells are not sensitive to differentiating agents, whereas M3 leukemic cells are induced to undergo granulocytic differentiation after ATRA treatment but are not sensitive to VD.
1	M0/M1	M0/M1	NUM	CD	NumType=Card	_	_	_	_
2	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	SCONJ	IN	_	_	_	_	_
8	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
12	M3	M3	NUM	CD	NumType=Card	_	_	_	_
13	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	undergo	undergo	VERB	VB	VerbForm=Inf	_	_	_	_
19	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	ATRA	Atra	PROPN	NNP	Number=Sing	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	VD	VD	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10139
# text = M2 leukemic blast cells behave differently because they undergo monocytic differentiation with both the differentiation inducers.
1	M2	M2	X	LS	_	_	_	_	_
2	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
3	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	behave	behave	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	differently	differently	ADV	RB	_	_	_	_	_
7	because	because	SCONJ	IN	_	_	_	_	_
8	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
9	undergo	undergo	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10140
# text = To gain some insight into the maturation of M2-type leukemic cells, we studied the molecular mechanisms underlying monocytic differentiation induced by ATRA and VD in spontaneous M2 blast cells as well as in Kasumi-1 cells (an acute myeloid leukemia M2-type cell line).
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	some	some	DET	DT	_	_	_	_	_
4	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	M2	m2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
20	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	VD	V	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
30	M2	m2	NUM	CD	NumType=Card	_	_	_	_
31	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	as	as	ADV	RB	_	_	_	_	_
34	well	well	ADV	RB	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	Kasumi	Kasumi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
44	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
45	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
46	M2	m2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	type	type	NOUN	NN	Number=Sing	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10141
# text = Our results indicate that ATRA as well as VD efficiently increases the nuclear abundance of VD receptor (VDR) and promotes monocytic differentiation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
6	as	as	ADV	RB	_	_	_	_	_
7	well	well	ADV	RB	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	VD	VD	PROPN	NNP	Number=Sing	_	_	_	_
10	efficiently	efficiently	ADV	RB	_	_	_	_	_
11	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	VD	V	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10142
# text = VDR is functionally active in ATRA-treated Kasumi-1 cells because it efficiently heterodimerizes with retinoid X receptor, binds to a DR3-type vitamin D-responsive element, and activates the transcription of a vitamin D-responsive element-regulated reporter gene.
1	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	functionally	functionally	ADV	RB	_	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	Kasumi	Kasumi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	because	because	SCONJ	IN	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	efficiently	efficiently	ADV	RB	_	_	_	_	_
16	heterodimerizes	heterodimerize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	_
19	X	x	ADP	IN	_	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	type	type	NOUN	NN	Number=Sing	_	_	_	_
28	vitamin	vitamin	NOUN	NNS	Number=Plur	_	_	_	_
29	D-	D-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
31	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
40	D-	D-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
41	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
42	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10143
# text = Consistent with these findings, VD-responsive genes are induced by ATRA treatment of Kasumi-1 cells, suggesting that the genetic program underlying monocytic differentiation is activated.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	VD	V	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ATRA	Atra	PROPN	NNP	Number=Sing	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Kasumi	Kasumi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
25	program	program	NOUN	NN	Number=Sing	_	_	_	_
26	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
27	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10144
# text = The molecular mechanism by which ATRA increases the nuclear abundance of a functional VDR is still unknown, but our data clearly indicate that the M2 leukemic cell context is only permissive of monocytic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
7	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	still	still	ADV	RB	_	_	_	_	_
17	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
21	data	data	NOUN	NN	Number=Sing	_	_	_	_
22	clearly	clearly	ADV	RB	_	_	_	_	_
23	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	M2	m2	NOUN	NN	Number=Sing	_	_	_	_
27	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	context	context	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10145
# text = Document 0030012084 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012084	0030012084	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10146
# text = Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	_
3	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
25	method	method	NOUN	NN	Number=Sing	_	_	_	_
26	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
27	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
28	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	assay	assay	VERB	VB	VerbForm=Inf	_	_	_	_
31	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10147
# text = Nuclear factor of activated T-cells (NFAT-1) is a transcription factor which is considered to be an important regulator in early T-cell activation.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
26	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10148
# text = We have developed a system to monitor the transcriptional activity of NFAT-1 at the single cell level in whole animals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	system	system	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
22	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10149
# text = The system is based on the use of an oligomerized NFAT-1 binding motif that directs transcription of SV40 T-antigen in transgenic mice.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	system	system	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	use	use	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	oligomerized	oligomerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
21	T-	T-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10150
# text = This report represents the first demonstration that a multimerized short binding motif can function appropriately in transgenic mice.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	report	report	NOUN	NN	Number=Sing	_	_	_	_
3	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
15	appropriately	appropriately	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10151
# text = NFAT-1 activity had previously been thought to be confined to activated T-lymphocytes upon release of intracellular calcium.
1	NFAT	Nfat	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	previously	previously	ADV	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	upon	upon	ADP	IN	_	_	_	_	_
17	release	release	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10152
# text = By targeting NFAT-1-dependent gene expression in transgenic mice we discovered new sites of NFAT-1 activity.
1	By	by	SCONJ	IN	_	_	_	_	_
2	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
3	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
12	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	discovered	discover	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10153
# text = Besides in T-lymphocytes NFAT-1 activity could also be induced in T-lymphocyte-depleted spleen cells and purified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C.
1	Besides	besides	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	spleen	spleen	NOUN	NNS	Number=Plur	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	release	release	NOUN	NN	Number=Sing	_	_	_	_
31	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
32	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
37	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10154
# text = A difference in the time course of appearance of NFAT-1 activity between T-lymphocytes and non-T-lymphocytes was revealed.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	time	time	NOUN	NN	Number=Sing	_	_	_	_
6	course	course	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	non-T-	non-t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10155
# text = Constitutive expression was observed in a small population of cells in the dermis and some mice have developed skin lesions.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
8	population	population	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	dermis	dermis	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	some	some	DET	DT	_	_	_	_	_
16	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	skin	skin	ADJ	JJ	Degree=Pos	_	_	_	_
20	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10156
# text = Interestingly, the tissue pattern of expression of the NFAT-1 activity resembles the expression pattern described for HIV-LTR/tat transgenic mice (Vogel, J., Hinrichs, S. H., Reynolds, R. K., Luciw, P. A., and Jay, G. (1988) Nature 335, 606-611).
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
5	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	resembles	resemble	NOUN	NNS	Number=Plur	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
18	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
25	transgenic	transgenic	NOUN	NN	Number=Sing	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Vogel	Vogel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	J.	J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	Hinrichs	Hinrichs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
35	H.	H.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	Reynolds	Reynolds	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	R.	R.	PROPN	NNP	Number=Sing	_	_	_	_
40	K.	K.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	Luciw	Luciw	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	P.	P.	PROPN	NNP	Number=Sing	_	_	_	_
45	A.	A.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	Jay	Jay	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	G.	G.	PROPN	NNP	Number=Sing	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	1988	1988	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	Nature	nature	NOUN	NN	Number=Sing	_	_	_	_
55	335	335	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	606-611	606-611	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10157
# text = This similarity in expression and the fact that NFAT-1 has been shown to bind functional sequences in HIV-LTR suggest a role for NFAT-1 in dermal activation of the HIV-LTR.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	ADV	WRB	PronType=Rel	_	_	_	_
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
17	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
23	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	dermal	dermal	ADJ	JJ	Degree=Pos	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10158
# text = Document 0030012086 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012086	0030012086	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10159
# text = The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
3	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10160
# text = All immunoglobulin genes contain a conserved octanucleotide promoter element, ATGCAAAT, which has been shown to be required for their normal B-cell-specific transcription.
1	All	all	DET	DT	_	_	_	_	_
2	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	octanucleotide	octanucleotide	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	ATGCAAAT	ATGCAAAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10161
# text = Proteins that bind this octamer have been purified, and cDNAs encoding octamer-binding proteins have been cloned.
1	Proteins	Protein	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cDNAs	cDNAs	SCONJ	IN	_	_	_	_	_
12	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
13	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10162
# text = Some of these proteins (referred to as OTF-2) are lymphoid specific, whereas at least one other, and possibly more (referred to as OTF-1), is found ubiquitously in all cell types.
1	Some	some	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	lymphoid	lymphoid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	ADV	RB	_	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	possibly	possibly	ADV	RB	_	_	_	_	_
25	more	more	ADV	RBR	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	all	all	DET	DT	_	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10163
# text = The exact role of these different proteins in directing the tissue-specific expression of immunoglobulin genes is unclear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10164
# text = We have identified two human pre-B-cell lines that contain extremely low levels of OTF-2 yet still express high levels of steady-state immunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an immunoglobulin gene in vitro.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	pre-B	pre-b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	extremely	extremely	ADV	RB	_	_	_	_	_
13	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	yet	yet	CCONJ	CC	_	_	_	_	_
20	still	still	ADV	RB	_	_	_	_	_
21	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	state	state	NOUN	NN	Number=Sing	_	_	_	_
28	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
29	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-chain	-chain	ADJ	JJ	Degree=Pos	_	_	_	_
31	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	efficiently	efficiently	ADV	RB	_	_	_	_	_
36	transcribe	transcribe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10165
# text = Addition of a highly enriched preparation of OTF-1 made from one of these pre-B cells or from HeLa cells specifically stimulated in vitro transcription of an immunoglobulin gene.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	highly	highly	ADV	RB	_	_	_	_	_
5	enriched	enriched	ADJ	JJ	Degree=Pos	_	_	_	_
6	preparation	preparation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	made	make	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
17	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	specifically	specifically	ADV	RB	_	_	_	_	_
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10166
# text = Furthermore, OFT-1 appeared to have approximately the same transactivation ability as OTF-2 when normalized for binding activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	OFT	OFT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
9	approximately	approximately	ADV	RB	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	normalized	normalized	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10167
# text = These results suggest that OTF-1, without OTF-2, is sufficient for transcription of immunoglobulin genes and that OTF-2 alone is not responsible for the B-cell-specific regulation of immunoglobulin gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	without	without	ADP	IN	_	_	_	_	_
10	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	OTF	Otf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	alone	alone	ADV	RB	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10168
# text = Document 0030012093 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012093	0030012093	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10169
# text = alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization.
1	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Tocopheryl	Tocopheryl	PROPN	NNP	Number=Sing	_	_	_	_
4	succinate	succinate	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
6	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10170
# text = The adherence of monocytes to activated endothelium is an early event in atherogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	event	event	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10171
# text = Because antioxidants have been considered to be of antiatherosclerotic potential, we investigated the effects of alpha-tocopherol (TCP) and its acetate and succinate esters on monocyte adhesion to cytokine-stimulated human umbilical vein endothelial cells (HUVEC).
1	Because	because	SCONJ	IN	_	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	antiatherosclerotic	antiatherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
10	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	succinate	succinate	ADJ	JJ	Degree=Pos	_	_	_	_
28	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
38	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
39	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10172
# text = Endothelial cells were treated with TCP, alpha-tocopherol acetate (TCP acetate), or alpha-tocopheryl succinate (TCP succinate) before stimulation with tumor necrosis factor-alpha (TNF-alpha; 10 U/ml, 6 h) or interleukin-1 beta (IL-1 beta; 10 U/ml, 6 h).
1	Endothelial	Endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	TCP	Tcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
11	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
14	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	tocopheryl	tocopheryl	NOUN	NN	Number=Sing	_	_	_	_
21	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TCP	Tcp	NOUN	NN	Number=Sing	_	_	_	_
24	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	before	before	ADP	IN	_	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
30	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	;	;	PUNCT	,	_	_	_	_	_
39	10	10	NUM	CD	NumType=Card	_	_	_	_
40	U/ml	u/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	6	6	NUM	CD	NumType=Card	_	_	_	_
43	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	or	or	CCONJ	CC	_	_	_	_	_
46	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	_
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	;	;	PUNCT	,	_	_	_	_	_
56	10	10	NUM	CD	NumType=Card	_	_	_	_
57	U/ml	u/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	6	6	NUM	CD	NumType=Card	_	_	_	_
60	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10173
# text = Cytokine-stimulated cell surface expression of vascular cell adhesion molecule-1 (VCAM-1, CD106) and E-selectin (ELAM-1, CD62E), but not of intercellular adhesion molecule-1 (ICAM-1, CD54), was time- and dose-dependently inhibited by TCP succinate but not by TCP or TCP acetate.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
11	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	CD106	CD106	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ELAM	ELAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	CD62E	CD62E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	not	not	ADV	RB	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	CD54	CD54	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
48	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	dependently	dependently	ADV	RB	_	_	_	_	_
54	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
57	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
58	but	but	CCONJ	CC	_	_	_	_	_
59	not	not	ADV	RB	_	_	_	_	_
60	by	by	ADP	IN	_	_	_	_	_
61	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
62	or	or	CCONJ	CC	_	_	_	_	_
63	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
64	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10174
# text = TCP succinate (200 microM, 24 h) reduced TNF-induced VCAM-1 and E-selectin expression from a specific mean fluorescence intensity of 151 +/- 28 to 12 +/- 4 channels and from 225 +/- 38 to 79 +/- 21 channels, respectively.
1	TCP	TCp	SYM	NFP	_	_	_	_	_
2	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	200	200	NUM	CD	NumType=Card	_	_	_	_
5	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	24	24	NUM	CD	NumType=Card	_	_	_	_
8	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	mean	mean	NOUN	NN	Number=Sing	_	_	_	_
25	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
26	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	151	151	NUM	CD	NumType=Card	_	_	_	_
29	+/-	+/-	SYM	SYM	_	_	_	_	_
30	28	28	NUM	CD	NumType=Card	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	12	12	NUM	CD	NumType=Card	_	_	_	_
33	+/-	+/-	SYM	SYM	_	_	_	_	_
34	4	4	NUM	CD	NumType=Card	_	_	_	_
35	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	225	225	NUM	CD	NumType=Card	_	_	_	_
39	+/-	+/-	SYM	SYM	_	_	_	_	_
40	38	38	NUM	CD	NumType=Card	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	79	79	NUM	CD	NumType=Card	_	_	_	_
43	+/-	+/-	SYM	SYM	_	_	_	_	_
44	21	21	NUM	CD	NumType=Card	_	_	_	_
45	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10175
# text = Succinate alone had no effect.
1	Succinate	Succinate	PROPN	NNP	Number=Sing	_	_	_	_
2	alone	alone	ADV	RB	_	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10176
# text = Decreased adhesion molecule expression was associated with a reduction of monocytic cell adhesion.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10177
# text = TCP succinate (20 microM, 72 h), but not TCP (200 microM, 72 h), reduced U-937 cell adhesion to TNF-alpha-stimulated (10 U/ml, 6 h) HUVEC by 30% (P < 0.025) and to IL-1 beta-stimulated HUVEC by 56% (P < 0.010).
1	TCP	TCp	SYM	NFP	_	_	_	_	_
2	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	20	20	NUM	CD	NumType=Card	_	_	_	_
5	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	72	72	NUM	CD	NumType=Card	_	_	_	_
8	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	TCP	Tcp	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	200	200	NUM	CD	NumType=Card	_	_	_	_
16	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	72	72	NUM	CD	NumType=Card	_	_	_	_
19	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	937	937	NUM	CD	NumType=Card	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	10	10	NUM	CD	NumType=Card	_	_	_	_
36	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	6	6	NUM	CD	NumType=Card	_	_	_	_
40	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	HUVEC	HUVEC	NOUN	NN	Number=Sing	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	%	%	SYM	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	P	p	NOUN	NN	Number=Sing	_	_	_	_
48	<	<	PUNCT	-LRB-	_	_	_	_	_
49	0.025	0.025	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	to	to	ADP	IN	_	_	_	_	_
53	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	_
56	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	HUVEC	Huvec	PROPN	NNP	Number=Sing	_	_	_	_
60	by	by	ADP	IN	_	_	_	_	_
61	56	56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	%	%	SYM	NN	Number=Sing	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	P	p	NOUN	NN	Number=Sing	_	_	_	_
65	<	<	PUNCT	-LRB-	_	_	_	_	_
66	0.010	0.010	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10178
# text = Electrophoretic mobility-shift assays of HUVEC nuclear proteins revealed a decrease in TNF-alpha-stimulated nuclear factor-kappa B (NF-kappa B) activation after pretreatment of HUVEC with TCP succinate but not with TCP, TCP acetate, or succinate alone.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HUVEC	Huvec	ADJ	JJ	Degree=Pos	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	TCP	TCP	NOUN	NN	Number=Sing	_	_	_	_
37	succinate	succinate	NOUN	NN	Number=Sing	_	_	_	_
38	but	but	CCONJ	CC	_	_	_	_	_
39	not	not	ADV	RB	_	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	TCP	TCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	TCP	TCP	PROPN	NNP	Number=Sing	_	_	_	_
44	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	or	or	CCONJ	CC	_	_	_	_	_
47	succinate	succinate	VERB	VB	VerbForm=Inf	_	_	_	_
48	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10179
# text = In conclusion, we demonstrate that the vitamin E derivative TCP succinate prevents monocytic cell adhesion to cytokine-stimulated endothelial cells by inhibiting the activation of NF-kappa B, further emphasizing the antiatherosclerotic potential of lipid soluble antioxidants.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
9	E	e	NOUN	NN	Number=Sing	_	_	_	_
10	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
11	TCP	Tcp	NOUN	NN	Number=Sing	_	_	_	_
12	succinate	succinate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	further	further	SCONJ	IN	_	_	_	_	_
34	emphasizing	emphasize	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	antiatherosclerotic	antiatherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
37	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
40	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
41	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10180
# text = Document 0030012098 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012098	0030012098	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10181
# text = Lineage- and stage-specific expression of runt box polypeptides in primitive and definitive hematopoiesis.
1	Lineage	Lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	runt	runt	NOUN	NN	Number=Sing	_	_	_	_
10	box	box	NOUN	NN	Number=Sing	_	_	_	_
11	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	definitive	definitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10182
# text = Translocations involving the human CBFA2 locus have been associated with leukemia.
1	Translocations	Translocation	NOUN	NNS	Number=Plur	_	_	_	_
2	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	CBFA2	Cbfa2	NOUN	NN	Number=Sing	_	_	_	_
6	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10183
# text = This gene, originally named AML1, is a human homologue of the Drosophila gene runt that controls early events in fly embryogenesis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	originally	originally	ADV	RB	_	_	_	_	_
5	named	name	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	runt	runt	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	events	event	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	fly	fly	ADJ	JJ	Degree=Pos	_	_	_	_
23	embryogenesis	embryogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10184
# text = To clarify the role of mammalian runt products in normal and leukemic hematopoiesis, we have studied their pattern of expression in mouse hematopoietic tissues in the adult and during ontogeny using an anti-runt box antiserum.
1	To	to	PART	TO	_	_	_	_	_
2	clarify	clarify	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
7	runt	runt	NOUN	NN	Number=Sing	_	_	_	_
8	products	product	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
13	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	during	during	ADP	IN	_	_	_	_	_
31	ontogeny	ontogeny	NOUN	NN	Number=Sing	_	_	_	_
32	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	anti-runt	anti-runt	ADJ	JJ	Degree=Pos	_	_	_	_
35	box	box	NOUN	NN	Number=Sing	_	_	_	_
36	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10185
# text = In the adult bone marrow, we found expression of runt polypeptides in differentiating myeloid cells and in B lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
4	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
5	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	runt	runt	ADJ	JJ	Degree=Pos	_	_	_	_
12	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10186
# text = Within the erythroid lineage, runt expression is biphasic, clearly present in the erythroblasts of early blood islands and of the fetal liver, but absent in the adult.
1	Within	within	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
4	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	runt	runt	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	clearly	clearly	ADV	RB	_	_	_	_	_
12	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	islands	island	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
24	liver	liver	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	adult	adult	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10187
# text = Biochemical analysis by Western blotting of fetal and adult hematopoietic populations shows several runt isoforms.
1	Biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
5	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
12	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	runt	runt	NOUN	NN	Number=Sing	_	_	_	_
15	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10188
# text = At least one of them appears to be myeloid specific.
1	At	at	ADV	RB	_	_	_	_	_
2	least	least	ADV	RBS	Degree=Sup	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
6	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	myeloid	myeloid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10189
# text = Document 0030012099 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012099	0030012099	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10190
# text = Some antioxidants inhibit, in a co-ordinate fashion, the production of tumor necrosis factor-alpha, IL-beta, and IL-6 by human peripheral blood mononuclear cells.
1	Some	some	DET	DT	_	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
3	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	co-ordinate	co-ordinate	ADJ	JJ	Degree=Pos	_	_	_	_
8	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
31	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10191
# text = Some antioxidants, including butylated hydroxyanisole (BHA), tetrahydropapaveroline (THP), nordihydroguiauretic acid, and 10,11-dihydroxyaporphine (DHA), were found to be potent inhibitors of the production of tumor necrosis factor (TNF)-alpha, IL-1 beta, and IL-6 by human peripheral blood mononuclear cells (PBMC) stimulated by lipopolysaccharide (LPS) (IC50s in the low micromolar range).
1	Some	some	DET	DT	_	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
5	butylated	butylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	hydroxyanisole	hydroxyanisole	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	BHA	BHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	tetrahydropapaveroline	tetrahydropapaveroline	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	nordihydroguiauretic	nordihydroguiauretic	ADJ	JJ	Degree=Pos	_	_	_	_
17	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	10,11	10,11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dihydroxyaporphine	dihydroxyaporphine	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	DHA	DHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
32	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	production	production	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
38	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	_
49	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	6	6	NUM	CD	NumType=Card	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
57	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
58	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
59	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
61	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
62	PBMC	PBMC	X	LS	_	_	_	_	SpaceAfter=No
63	)	)	PUNCT	-RRB-	_	_	_	_	_
64	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
65	by	by	ADP	IN	_	_	_	_	_
66	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
67	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
68	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	)	)	PUNCT	-RRB-	_	_	_	_	_
70	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
71	IC50s	IC50	NOUN	NNS	Number=Plur	_	_	_	_
72	in	in	ADP	IN	_	_	_	_	_
73	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
74	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
75	micromolar	micromolar	ADJ	JJ	Degree=Pos	_	_	_	_
76	range	range	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10192
# text = Inhibition of cytokine production was gene selective and not due to general effects on protein synthesis.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
7	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	due	due	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
13	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10193
# text = Inhibition of cytokine production by PBMC was observed also when other inducers were used (staphylococci, silica, zymosan).
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	staphylococci	staphylococci	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	silica	silica	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	zymosan	zymosan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10194
# text = Much higher concentrations of other antioxidants--including ascorbic acid, trolox, alpha-tocopherol, butylated hydroxytoluene, and the 5-lipoxygenase inhibitor zileuton--did not affect the production of these cytokines.
1	Much	much	ADJ	JJ	Degree=Pos	_	_	_	_
2	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
6	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	ascorbic	ascorbic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	trolox	trolox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	butylated	butylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	hydroxytoluene	hydroxytoluene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
26	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
27	zileuton	zileuton	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
29	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	production	production	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
36	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10195
# text = The active compounds did not inhibit IL-1-induced production of IL-6 in fibroblasts, showing the cell selectivity of the effect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	selectivity	selectivity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10196
# text = Antioxidant-mediated inhibition of cytokine production was correlated with low levels of the corresponding messenger RNAs.
1	Antioxidant	Antioxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	corresponding	correspond	NOUN	NN	Number=Sing	_	_	_	_
16	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
17	RNAs	RNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10197
# text = Nuclear run-on experiments showed that THP inhibited transcription of the IL-1 beta gene.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	THP	THP	PROPN	NNP	Number=Sing	_	_	_	_
9	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10198
# text = THP decreased the concentration of the transcription factors NF-kappa B and AP-1 detected in nuclear extracts of PBMC cultured in the presence or absence of LPS.
1	THP	THp	SYM	NFP	_	_	_	_	_
2	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
23	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10199
# text = THP and DHA markedly decreased the levels of TNF-alpha and IL-1 beta in the circulation of mice following LPS injection.
1	THP	THP	SYM	NFP	_	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	DHA	DHA	PROPN	NNP	Number=Sing	_	_	_	_
4	markedly	markedly	ADV	RB	_	_	_	_	_
5	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	circulation	circulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
22	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
23	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
24	injection	injection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10200
# text = Thus antioxidants vary widely in potency as inhibitors of the activation of transcription factors and of the transcription of genes for pro-inflammatory cytokines.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	antioxidants	antioxidant	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	vary	vary	ADJ	JJ	Degree=Pos	_	_	_	_
4	widely	widely	ADV	RB	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10201
# text = Coordinate inhibition of the transcription of genes for inflammatory cytokines could provide a strategy for therapy of diseases with inflammatory pathogenesis and for septic shock.
1	Coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
25	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10202
# text = Document 0030012103 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012103	0030012103	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10203
# text = Activation of nuclear factor-kappaB by lipopolysaccharide in mononuclear leukocytes is prevented by inhibitors of cytosolic phospholipase A2.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
18	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
19	A2	a2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10204
# text = In monocytes, lipopolysaccharide induces synthesis and activity of the 85-kDa cytosolic phospholipase A2.
1	In	in	ADP	IN	_	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	85	85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
14	cytosolic	cytosolic	NOUN	NN	Number=Sing	_	_	_	_
15	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
16	A2	A2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10205
# text = This enzyme releases arachidonic acid and lyso-phospholipids from membranes which are metabolized to eicosanoids and platelet-activating-factor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
3	releases	release	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	arachidonic	arachidonic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	lyso	lyso	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-phospholipids	-phospholipid	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	metabolized	metabolize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	eicosanoids	eicosanoid	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-activating	-activat	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	-factor	-factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10206
# text = These lipid mediators increase activity of transcription factors and expression of cytokine genes indicating a function for cytosolic phospholipase A2 in signal transduction and inflammation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
3	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
4	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
19	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
20	A2	a2	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
23	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10207
# text = We have shown previously that trifluoromethylketone inhibitors of cytosolic phospholipase
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	previously	previously	ADV	RB	_	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	trifluoromethylketone	trifluoromethylketone	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
10	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10208
# text = A2 suppressed interleukin-1beta protein and steady-state mRNA levels in human lipopolysaccharide-stimulated peripheral blood mononuclear leukocytes.
1	A2	A2	PART	TO	Abbr=Yes	_	_	_	_
2	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	state	state	NOUN	NN	Number=Sing	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10209
# text = In this study, the subcellular mechanisms were analyzed by which trifluoromethylketones interfere with gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	subcellular	subcellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Int	_	_	_	_
12	trifluoromethylketones	trifluoromethylketones	NOUN	NNS	Number=Plur	_	_	_	_
13	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10210
# text = We found that they reduced the initial interleukin-1beta mRNA transcription rate through prevention of degradation of inhibitor-kappaB alpha.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
5	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	mRNA	mRNa	SYM	SYM	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10211
# text = Consequently, cytosolic activation, nuclear translocation and DNA-binding of nuclear factor-kappaB were decreased.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10212
# text = Trifluoromethylketones ameliorate chronic inflammation in vivo.
1	Trifluoromethylketones	Trifluoromethylketone	NOUN	NNS	Number=Plur	_	_	_	_
2	ameliorate	ameliorate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
4	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10213
# text = Thus, this therapeutic potency may reside in retention of inactive nuclear factor-kappaB in the cytosol thereby abrogating interleukin-1beta gene transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
5	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	reside	reside	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	retention	retention	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
19	thereby	thereby	ADV	RB	_	_	_	_	_
20	abrogating	abrogat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	interleukin	interleukin	ADV	RB	_	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10214
# text = Document 0030012104 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012104	0030012104	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10215
# text = C/EBP activators are required for HIV-1 replication and proviral induction in monocytic cell lines.
1	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	EBP	Ebp	PROPN	NNP	Number=Sing	_	_	_	_
4	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10216
# text = Previous work has shown that C/EBP sites and C/EBP transcriptional activators are necessary for HIV-1 LTR activity in monocytes/macrophages.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10217
# text = We have investigated the role that C/EBP proteins play in induction and replication of HIV-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10218
# text = Ectopic expression of the dominant negative C/EBP protein LIP inhibited HIV-1 mRNA and virus production in activated U1 cells, demonstrating that C/EBP proteins are required for provirus induction.
1	Ectopic	Ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	LIP	lip	NOUN	NN	Number=Sing	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	U1	U1	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	EBP	Ebp	PROPN	NNP	Number=Sing	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	provirus	provirus	ADJ	JJ	Degree=Pos	_	_	_	_
35	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10219
# text = U1 lines overexpressing C/EBP activator NF-IL-6 produced more viral mRNA and virus particles following cellular activation than control lines, demonstrating that C/EBP proteins are limiting for virus transcription.
1	U1	U1	NUM	CD	NumType=Card	_	_	_	_
2	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
3	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
4	C/	C/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
5	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
6	activator	activator	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
14	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	particles	particle	NOUN	NNS	Number=Plur	_	_	_	_
19	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	control	control	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	demonstrating	demonstrate	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	EBP	Ebp	PROPN	NNP	Number=Sing	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	limiting	limit	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10220
# text = HIV-1 harboring mutations within two C/EBP sites were crippled in their ability to replicate in U937 promonocytic cells, indicating that these sites are required for replication.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	harboring	harboring	NOUN	NN	Number=Sing	_	_	_	_
5	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	C/	C/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	EBP	Ebp	PROPN	NNP	Number=Sing	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	crippled	crippl	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	U937	U937	NUM	CD	NumType=Card	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10221
# text = These data identify C/EBP proteins as regulators of HIV-1 expression in monocytes/macrophages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	identify	identify	NOUN	NN	Number=Sing	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	macrophages.	macrophages.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10222
# text = Document 0030012109 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012109	0030012109	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10223
# text = The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10224
# text = The development of resistance to host defense mechanisms such as tumor necrosis factor (TNF)- and Fas-mediated apoptosis of transformed or virus-infected cells may be a critical component in the development of disease.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	host	host	VERB	VB	VerbForm=Inf	_	_	_	_
7	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
8	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
9	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
32	component	component	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	development	development	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10225
# text = To find genes that protect cells from apoptosis, we used an expression cloning strategy and identified BHRF1, an Epstein-Barr virus (EBV) early-lytic-cycle protein with distant homology to Bcl-2, as an anti-apoptosis protein.
1	To	to	PART	TO	_	_	_	_	_
2	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	protect	protect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
15	strategy	strategy	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	early	early	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-lytic	-lytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	distant	distant	ADJ	JJ	Degree=Pos	_	_	_	_
35	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	anti-apoptosis	anti-apoptosis	ADJ	JJ	Degree=Pos	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10226
# text = Expression of BHRF1 in MCF-Fas cells conferred nearly complete resistance against both anti-Fas antibody and TNF-mediated apoptosis.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	MCF	MCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	nearly	nearly	ADV	RB	_	_	_	_	_
11	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
12	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
13	against	against	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	anti-Fas	anti-Fas	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10227
# text = In addition, BHRF1 protected these cells from monocyte-mediated killing but failed to protect them from killing mediated by lymphokine-activated killer cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	BHRF1	BHRF1	NUM	CD	NumType=Card	_	_	_	_
5	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	monocyte-	monocyte-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	killing	kille	VERB	VBG	VerbForm=Ger	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
16	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	killing	kill	NOUN	NN	Number=Sing	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10228
# text = The ability of BHRF1 to protect MCF-Fas cells from apoptosis induced by various stimuli was identical to that of Bcl-2 and Bcl-xL.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
7	MCF	MCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
16	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	xL	xL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10229
# text = Moreover, the mechanism of action of BHRF1 resembled that of Bcl-2 and Bcl-xL as it inhibited TNF- and anti-Fas-induced activation of two enzymes participating in the apoptosis pathway, cytosolic phospholipase
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	action	action	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
9	resembled	resemble	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	xL	xL	NOUN	NN	Number=Sing	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	anti-Fas-induced	anti-Fas-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
30	participating	participate	VERB	VBG	VerbForm=Ger	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
37	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10230
# text = A2 and caspase-3/CPP32, but did not interfere with the activation of NF-kappaB-like transcription factors.
1	A2	A2	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	caspase-3/CPP32	caspase-3/CPP32	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10231
# text = A putative function of BHRF1 in EBV-infected epithelial cells may be to protect virus-infected cells from TNF- and/or anti-Fas- induced cell death in order to maximize virus production.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	function	function	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	or	or	CCONJ	CC	_	_	_	_	_
26	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
27	-Fas	-Fas	ADV	RB	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	death	death	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	order	order	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	maximize	maximize	VERB	VB	VerbForm=Inf	_	_	_	_
36	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
37	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10232
# text = Surprisingly, expression of neither BHRF1 nor Bcl-2 in a B-cell line, BJAB, protected the cells from anti-Fas-mediated apoptosis even though they increased the survival of serum-starved cells.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	neither	neither	DET	DT	_	_	_	_	_
6	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
7	nor	nor	CCONJ	CC	_	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	BJAB	BJAB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	protected	protect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	anti-Fas-	anti-Fas-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	even	even	ADV	RB	_	_	_	_	_
28	though	though	SCONJ	IN	_	_	_	_	_
29	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
30	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	starved	starve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10233
# text = Thus, the protective role of BHRF1 against apoptosis resembles that of Bcl-2 in being cell type specific and dependent on the apoptotic stimulus.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protective	protective	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	BHRF1	BHRF1	NUM	CD	NumType=Card	_	_	_	_
8	against	against	ADP	IN	_	_	_	_	_
9	apoptosis	apoptosis	ADJ	JJ	Degree=Pos	_	_	_	_
10	resembles	resemble	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	ADV	WRB	PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	being	being	AUX	VBG	VerbForm=Ger	_	_	_	_
18	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
26	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10234
# text = Document 0030012117 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012117	0030012117	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10235
# text = In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	death	death	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	metalloproteinases	metalloproteinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10236
# text = Cellular pathways for induction of programmed cell death (PCD) have been identified, but little is known about specific extracellular matrix processes that may affect apoptosis along those pathways.
1	Cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	death	death	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PCD	pCd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	about	about	ADP	IN	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
24	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
28	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
29	along	along	ADP	IN	_	_	_	_	_
30	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10237
# text = In this study, a series of Burkitt's lymphoma (BL) cell lines were assayed for their expression of tissue inhibitor of metalloproteinases (TIMP)-1.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	series	series	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	's	's	PART	POS	_	_	_	_	_
10	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
23	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	metalloproteinases	metalloproteinase	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TIMP	TIMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10238
# text = Results indicate that TIMP-1-positive BL lines show resistance to cold-shock-induced apoptosis.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
9	BL	Bl	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	cold	cold	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10239
# text = Furthermore, recombinant TIMP-1, but not TIMP-2 or a synthetic metalloproteinase inhibitor (BB-94), confers resistance to apoptosis induced by both CD95-dependent and -independent (cold shock, serum deprivation, and gamma-radiation) pathways in TIMP-1-negative BL lines.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
4	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
16	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	BB	bb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	94	94	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
25	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	CD95	Cd95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	cold	cold	ADJ	JJ	Degree=Pos	_	_	_	_
39	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
42	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	TIMP	TIMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
56	BL	Bl	NOUN	NN	Number=Sing	_	_	_	_
57	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10240
# text = TIMP-1 suppression of PCD is not due to metalloproteinase inhibition, as reduction and alkylation of the TIMP-1 did not abolish this activity.
1	TIMP	Timp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	PCD	PCD	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	due	due	ADP	IN	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	alkylation	alkylation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	abolish	abolish	VERB	VB	VerbForm=Inf	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10241
# text = Retroviral induction of TIMP-1 not only resulted in cell survival but also in continued DNA synthesis for up to 5 d in the absence of serum, while controls underwent apoptosis.
1	Retroviral	Retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TIMP	TIMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	only	only	ADV	RB	_	_	_	_	_
9	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	continued	continue	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	up	up	ADP	RP	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	_
23	d	d	PROPN	NNP	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	while	while	SCONJ	IN	_	_	_	_	_
31	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
32	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10242
# text = This resistance to apoptosis is reversed by anti-TIMP-1 antibodies, demonstrating that secreted TIMP-1 is active in blocking apoptosis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	anti-TIMP	anti-TIMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
23	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10243
# text = Furthermore, TIMP-1 upregulation induced expression of Bcl-XL but not Bcl-2 as well as decreased NF-kappaB activity as compared with controls.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TIMP	TIMP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	XL	XL	PROPN	NNP	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	as	as	SCONJ	IN	_	_	_	_	_
27	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10244
# text = These results demonstrate that TIMP-1 suppresses apoptosis in B cells and suggests a novel activity for TIMP-1 in tissue homeostasis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TIMP	Timp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	TIMP	TIMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
24	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10245
# text = Document 0030012126 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012126	0030012126	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10246
# text = Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.
1	Cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	core	core	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10247
# text = Tissue-specific expression of interleukin-3 (IL-3) is mediated via cis-acting elements located within 315 base pairs of the transcription start.
1	Tissue	Tissue	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	3	3	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
18	-acting	-act	ADJ	JJ	Degree=Pos	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	315	315	NUM	CD	NumType=Card	_	_	_	_
23	base	base	NOUN	NN	Number=Sing	_	_	_	_
24	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	start	start	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10248
# text = This is achieved in part through the positive activities of the AP-1 and Elf-1 sites in the IL-3 promoter.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	part	part	NOUN	NN	Number=Sing	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Elf	Elf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10249
# text = The contribution to T cell-specific expression by other promoter sites was assessed in a transient expression assay with IL-3 promoter constructs linked to a luciferase gene, focusing initially on the core binding factor (CBF) site, which is footprinted in vivo upon T cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
26	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	focusing	focus	VERB	VBG	VerbForm=Ger	_	_	_	_
33	initially	initially	ADV	RB	_	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	core	core	NOUN	NN	Number=Sing	_	_	_	_
37	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	which	which	PRON	WDT	PronType=Rel	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	footprinted	footprint	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
49	upon	upon	ADP	IN	_	_	_	_	_
50	T	t	PROPN	NNP	Number=Sing	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10250
# text = Activity of the CBF site is shown to be critically dependent on the adjacent activator site Act-1.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	critically	critically	ADV	RB	_	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	Act	act	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10251
# text = Together the Act-1 and CBF sites form a functional unit (AC unit) with dual activity.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	Act	act	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	form	form	ADP	IN	Typo=Yes	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	unit	unit	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	AC	Ac	NOUN	NN	Number=Sing	_	_	_	_
15	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10252
# text = The AC unit is demonstrated to enhance basal activity of promoters both in fibroblasts and T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AC	Ac	NOUN	NN	Number=Sing	_	_	_	_
3	unit	unit	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
8	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10253
# text = This activity is further inducible in activated T cells, but not in fibroblasts.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10254
# text = In addition to the already identified NIP repressor site, evidence is presented for a second repressor region that restricts promoter activity in fibroblasts.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	already	already	ADV	RB	_	_	_	_	_
6	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NIP	Nip	NOUN	NN	Number=Sing	_	_	_	_
8	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	restricts	restrict	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10255
# text = Finally, a novel positive regulatory element has been mapped in the IL-3 promoter between nucleotide -180 and -210 that leads to increased expression in T cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	180	180	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	210	210	NUM	CD	NumType=Card	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	increased	increase	VERB	VB	VerbForm=Inf	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10256
# text = Together these results demonstrate that T cell expression of IL-3 is not specified by the activity of a single tissue-specific element, but instead involves multiple interacting elements that provide both specific positive regulation in T cells and specific negative regulation in fibroblasts.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	specified	specify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
22	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	instead	instead	ADV	RB	_	_	_	_	_
29	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
31	interacting	interacting	ADJ	JJ	Degree=Pos	_	_	_	_
32	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	both	both	DET	DT	_	_	_	_	_
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
38	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
44	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
45	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10257
# text = Document 0030012127 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012127	0030012127	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10258
# text = Relief of cyclin
1	Relief	relief	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10259
# text = A gene transcriptional inhibition during activation of human primary T lymphocytes via CD2 and CD28 adhesion molecules.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	NOUN	NN	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10260
# text = Cyclin
1	Cyclin	Cyclin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 10261
# text = A transcription is cell cycle regulated and induced by cell proliferative signals.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10262
# text = To understand the mechanisms underlined in this regulation in normal human cells, we have analysed in vivo protein-DNA interactions at the Cyclin A locus in primary T lymphocytes.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	underlined	underlin	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Cyclin	Cyclin	PROPN	NNP	Number=Sing	_	_	_	_
26	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10263
# text = Stimulation of purified T lymphocytes by a combination of monoclonal antibodies directed at CD2 and CD28 adhesion molecules gives rise to a long lasting proliferation in the absence of accessory cells.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
12	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
19	gives	give	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	rise	rise	VERB	VB	VerbForm=Inf	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
24	lasting	lasting	NOUN	NN	Number=Sing	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10264
# text = Cyclin
1	Cyclin	Cyclin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 10265
# text = A was observed after 4 days of costimulation with anti CD2 + CD28 whereas stimulation by anti CD2 or anti CD28 alone was not effective.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	days	day	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	anti	anti	X	AFX	_	_	_	_	_
11	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
12	+	+	SYM	SYM	_	_	_	_	_
13	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
14	whereas	whereas	NOUN	NNS	Number=Plur	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	anti	anti	X	AFX	_	_	_	_	_
18	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	anti	anti	X	AFX	_	_	_	_	_
21	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
22	alone	alone	ADV	RB	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10266
# text = In vivo genomic DMS footprinting revealed upstream of the major transcription initiation sites, the presence of at least three protein binding sites, two of which were constitutively occupied.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
4	DMS	Dm	NOUN	NNS	Number=Plur	_	_	_	_
5	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
6	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	three	three	NUM	CD	NumType=Card	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	constitutively	constitutively	ADV	RB	_	_	_	_	_
30	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10267
# text = They bind in vitro respectively ATF-1 and NF-Y proteins.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
5	respectively	respectively	ADV	RB	_	_	_	_	_
6	ATF	Atf	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Y	y	NOUN	NN	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10268
# text = The third site was occupied in quiescent cells or in cells stimulated by anti CD2 or anti CD28 alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	anti	anti	X	AFX	_	_	_	_	_
15	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	anti	anti	X	AFX	_	_	_	_	_
18	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
19	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10269
# text = The mitogenic combination of anti CD2 + anti CD28 released the footprint as cells were committed to proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
3	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	anti	anto	X	AFX	_	_	_	_	_
6	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
7	+	+	SYM	SYM	_	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	released	release	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	committed	commit	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10270
# text = Consistent with theses results, nuclear extracts prepared from quiescent cells formed a specific complex with this element, whereas extracts prepared from cells treated with anti CD2 + anti CD28 failed to do so after cells entered a proliferative state.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
4	s	's	PART	POS	_	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
23	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	anti	anti	X	AFX	_	_	_	_	_
29	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
30	+	+	SYM	SYM	_	_	_	_	_
31	anti	anti	X	AFX	_	_	_	_	_
32	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
33	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	do	do	VERB	VB	VerbForm=Inf	_	_	_	_
36	so	so	ADV	RB	_	_	_	_	_
37	after	after	SCONJ	IN	_	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	entered	enter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
42	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10271
# text = Document 0030012134 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012134	0030012134	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10272
# text = A factor known to bind to endogenous
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	endogenous	endogenous	X	ADD	_	_	_	_	_

# sent_id = 10273
# text = Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphocytes	lymphocytes	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10274
# text = The transcriptional enhancer located in the first intron of the immunoglobulin heavy chain constant region is a major determinant of B-cell-specific expression of immunoglobulin genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
12	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10275
# text = Like other enhancers, the Ig heavy chain enhancer contains several short sequence motifs that bind specific transcription factors.
1	Like	like	ADP	IN	_	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
7	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10276
# text = Each binding site contributes to the overall activity of the enhancer, however no single element seems absolutely required for activity.
1	Each	each	DET	DT	_	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	absolutely	absolutely	ADV	RB	_	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10277
# text = For a better understanding of the
1	For	for	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
4	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_

# sent_id = 10278
# text = Ig heavy chain enhancer components, we have cloned and analyzed individual sequence elements.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10279
# text = We find that the factor that binds to the E3 enhancer motif, CATGTGGC, is a ubiquitous transcription factor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CATGTGGC	CATGTGGC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10280
# text = It is present in an active form in both B cells and non-B cells, where it can mediate transcriptional activation in vitro and in vivo.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	non	non	X	AFX	_	_	_	_	SpaceAfter=No
14	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	where	where	ADV	WRB	PronType=Rel	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10281
# text = However, despite its ability to activate transcription of a transfected reporter gene, the factor is apparently unable to bind to the endogenous
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	despite	despite	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	apparently	apparently	ADV	RB	_	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	endogenous	endogenous	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10282
# text = Ig heavy chain enhancer in non-lymphoid cells:
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	non-lymphoid	non-lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 10283
# text = In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3, was detected in B cells but not in non-B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
11	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	muE3	muE3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	non	non	X	AFX	_	_	_	_	SpaceAfter=No
30	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10284
# text = From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes: (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa
1	From	from	ADP	IN	_	_	_	_	_
2	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	picture	picture	NOUN	NN	Number=Sing	_	_	_	_
8	emerges	emerge	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	there	there	PRON	EX	_	_	_	_	_
11	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	three	three	NUM	CD	NumType=Card	_	_	_	_
15	categories	category	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	a	a	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
37	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
38	as	as	ADP	IN	_	_	_	_	_
39	Oct-2A	Oct-2A	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2B	2b	NOUN	NN	Number=Sing	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	not	not	PART	RB	_	_	_	_	_
47	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
50	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	:	:	PUNCT	:	_	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	b	b	X	LS	_	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
58	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
59	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
60	as	as	ADP	IN	_	_	_	_	_
61	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 10285
# text = B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors, exemplified by the one binding to the E3 sequence motif.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
15	form	form	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	c	c	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	exemplified	exemplify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	one	one	NOUN	NN	Number=Sing	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
35	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
36	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10286
# text = This factor is present in an active form in a variety of cell types but is apparently unable to bind to the endogenous
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	form	form	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	types	type	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	apparently	apparently	ADV	RB	_	_	_	_	_
18	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	endogenous	endogenous	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10287
# text = Ig heavy chain enhancer in non-B cells, perhaps due to a non-permissive chromatin structure of the Ig heavy chain locus.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	non	non	X	AFX	_	_	_	_	SpaceAfter=No
7	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	perhaps	perhaps	ADV	RB	_	_	_	_	_
11	due	due	ADP	IN	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	non-permissive	non-permissive	ADJ	JJ	Degree=Pos	_	_	_	_
15	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
16	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
20	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
21	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
22	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10288
# text = Document 0030012135 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012135	0030012135	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10289
# text = Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10290
# text = Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood.
1	Malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
2	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
3	usually	usually	ADV	RB	_	_	_	_	_
4	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10291
# text = PU.1 is a hematopoietic-specific Ets family transcription factor that is required for development of some lymphoid and myeloid lineages.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	some	some	DET	DT	_	_	_	_	_
18	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
21	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10292
# text = PU.1 can also act as an oncoprotein as activation of its expression in erythroid precursors by proviral insertion or transgenesis causes erythroleukemias in mice.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
18	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	transgenesis	transgenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	erythroleukemias	erythroleukemia	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10293
# text = Restoration of terminal differentiation in the mouse erythroleukemia (MEL) cells requires a decline in the level of PU.1, indicating that PU.1 can block erythroid differentiation.
1	Restoration	restoration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
8	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	MEL	MEL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	PU.1	PU.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
27	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10294
# text = Here we investigate the mechanism by which PU.1 interferes with erythroid differentiation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
9	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10295
# text = We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
5	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
14	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10296
# text = Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
9	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10297
# text = PU.1 represses GATA-1-mediated transcriptional activation.
1	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
2	represses	represse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10298
# text = Both the DNA binding and transactivation domains of PU.1 are required for repression and both domains are also needed to block terminal differentiation in MEL cells.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	needed	need	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
22	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	MEL	Mel	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10299
# text = We also show that ectopic expression of PU.1 in Xenopus embryos is sufficient to block erythropoiesis during normal development.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Xenopus	Xenopus	PROPN	NNP	Number=Sing	_	_	_	_
11	embryos	embryo	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
16	erythropoiesis	erythropoiesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10300
# text = Furthermore, introduction of exogenous GATA-1 in both MEL cells and Xenopus embryos and explants relieves the block to erythroid differentiation imposed by PU.1.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
6	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	MEL	Mel	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Xenopus	Xenopus	ADJ	JJ	Degree=Pos	_	_	_	_
14	embryos	embryo	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	explants	explant	NOUN	NNS	Number=Plur	_	_	_	_
17	relieves	relieve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	block	block	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	erythroid	erythroid	VERB	VB	VerbForm=Inf	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	imposed	impose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10301
# text = Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	stoichiometry	stoichiometry	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	SCONJ	IN	_	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	_
9	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	opposing	oppos	VERB	VBG	VerbForm=Ger	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
18	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
19	governing	govern	VERB	VBG	VerbForm=Ger	_	_	_	_
20	processes	processe	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
26	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10302
# text = Document 0030012137 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012137	0030012137	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10303
# text = Phosphorylation of TRAF2 inhibits binding to the CD40 cytoplasmic domain.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
9	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
10	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10304
# text = TRAF2 is a signal transducing adaptor molecule which binds to the CD40 cytoplasmic domain.
1	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
6	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10305
# text = We have found that it is phosphorylated, predominantly on serine residues, when transiently overexpressed in 293 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	predominantly	predominantly	ADV	RB	_	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
12	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	transiently	transiently	ADV	RB	_	_	_	_	_
16	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	293	293	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10306
# text = The phosphorylation appears to be related to the signaling events that are activated by TRAF2 under these circumstances, since two nonfunctional mutants were found to be phosphorylated significantly less than the wild-type protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
10	events	event	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
16	under	under	ADP	IN	_	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	circumstances	circumstance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	since	since	ADP	IN	_	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	nonfunctional	nonfunctional	ADJ	JJ	Degree=Pos	_	_	_	_
23	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	significantly	significantly	ADV	RB	_	_	_	_	_
30	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
31	than	than	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	type	type	NOUN	NN	Number=Sing	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10307
# text = Furthermore, the phosphorylation status of TRAF2 had significant effects on the ability of the protein to bind to CD40, as evidenced by our observations that the CD40 cytoplasmic domain interacted preferentially with underphosphorylated TRAF2 and that phosphatase treatment significantly enhanced the binding of TRAF2 to CD40.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	status	status	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
26	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
30	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
31	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
32	interacted	interact	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	preferentially	preferentially	ADV	RB	_	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	underphosphorylated	underphosphorylated	ADJ	JJ	Degree=Pos	_	_	_	_
36	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
39	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
40	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
41	significantly	significantly	ADV	RB	_	_	_	_	_
42	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	_
47	to	to	ADP	IN	_	_	_	_	_
48	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10308
# text = We conclude from these studies that the phosphorylation of TRAF2 is likely to play an important role in regulating signaling by virtue of its ability to influence the CD40-TRAF2 interaction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	virtue	virtue	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	_
32	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10309
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10310
# text = Document 0030012151 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012151	0030012151	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10311
# text = Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter.
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	families	family	NOUN	NNS	Number=Plur	_	_	_	_
13	target	target	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
16	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
22	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10312
# text = CD40 activation of B cells is strongly influenced by the presence of cytokines.
1	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	strongly	strongly	ADV	RB	_	_	_	_	_
8	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10313
# text = However, the molecular basis for the interplay between these distinct stimuli is not clearly delineated.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
12	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	clearly	clearly	ADV	RB	_	_	_	_	_
16	delineated	delineated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10314
# text = IFN regulatory factor 1 (IRF-1) is a transcription factor activated by either CD40 or cytokines.
1	IFN	Ifn	ADP	IN	_	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	X	LS	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10315
# text = We have found that these different sets of signals target a common cis-acting element in the promoter of this gene, the IRF-1 gamma-activated site (GAS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
7	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
10	target	target	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	GAS	Gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10316
# text = Targeting of the IRF-1 GAS is not confined to activation via CD40 but extends to other stimuli that mimic the CD40 signaling cascade, like TNF-alpha and EBV.
1	Targeting	targeting	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	extends	extend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
24	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
25	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	like	like	ADP	IN	_	_	_	_	_
28	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10317
# text = In contrast to induction of STATs by cytokines, the IRF-1 GAS-binding complex activated by CD40, TNF-alpha, or EBV contains
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STATs	STAT	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	GAS	gas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
28	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_

# sent_id = 10318
# text = Rel proteins, specifically p50 and p65.
1	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	specifically	specifically	ADV	RB	_	_	_	_	_
5	p50	p50	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10319
# text = In this system, simultaneous exposure to CD40L together with either IL-4 or IFN-gamma does not lead to the activation of novel Rel/STAT complexes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
6	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	CD40L	Cd40l	VERB	VB	VerbForm=Inf	_	_	_	_
9	together	together	ADV	RB	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	either	either	DET	DT	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
19	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
27	Rel/	Rel/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
29	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10320
# text = Given the importance of IRF-1 in a variety of biologic functions from proliferation to apoptosis, our findings support the notion that modulation of IRF-1 levels may be a critical control point in B cell activation.
1	Given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
13	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
20	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
21	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
35	control	control	NOUN	NN	Number=Sing	_	_	_	_
36	point	point	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10321
# text = Document 0030012160 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012160	0030012160	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10322
# text = Signal transduction pathways activated in endothelial cells following infection with Chlamydia pneumoniae.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Chlamydia	Chlamydia	PROPN	NNP	Number=Sing	_	_	_	_
12	pneumoniae	pneumonia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10323
# text = Chlamydia pneumoniae is an important respiratory pathogen.
1	Chlamydia	Chlamydia	PROPN	NNP	Number=Sing	_	_	_	_
2	pneumoniae	pneumoniae	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
7	pathogen	pathogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10324
# text = Recently, its presence has been demonstrated in atherosclerotic lesions.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10325
# text = In this study, we characterized C. pneumoniae-mediated activation of endothelial cells and demonstrated an enhanced expression of endothelial adhesion molecules followed by subsequent rolling, adhesion, and transmigration of leukocytes (monocytes, granulocytes).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
8	pneumoniae	pneumoniae	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
27	rolling	rolling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	transmigration	transmigration	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10326
# text = These effects were blocked by mAbs against endothelial and/or leukocyte adhesion molecules (beta1 and beta2 integrins).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
7	against	against	ADP	IN	_	_	_	_	_
8	endothelial	endothelial	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	or	or	CCONJ	CC	_	_	_	_	_
12	leukocyte	leukocyte	VERB	VB	VerbForm=Inf	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
19	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10327
# text = Additionally, activation of different signal transduction pathways in C. pneumoniae-infected endothelial cells was shown: protein tyrosine phosphorylation, up-regulation of phosphorylated p42/p44 mitogen-activated protein kinase, and NF-kappaB activation/translocation occurred within 10-15 min.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
7	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
8	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
11	pneumoniae	pneumonia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	p42	p42	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	p44	p44	NUM	CD	NumType=Card	_	_	_	_
31	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	-activated	-activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
42	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
43	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	within	within	ADP	IN	_	_	_	_	_
45	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	15	15	NUM	CD	NumType=Card	_	_	_	_
48	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10328
# text = Increased mRNA and surface expression of E-selectin, ICAM-1, and VCAM-1 were noted within hours.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10329
# text = Thus, C. pneumoniae triggers a cascade of events that could lead to endothelial activation, inflammation, and thrombosis, which in turn may result in or may promote atherosclerosis.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
4	pneumoniae	pneumoniae	NOUN	NN	Number=Sing	_	_	_	_
5	triggers	trigger	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	thrombosis	thrombosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
31	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10330
# text = Document 0030012161 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012161	0030012161	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10331
# text = A functional T-cell receptor signaling pathway is required for p95vav activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10332
# text = Stimulation of the T-cell antigen receptor (TCR) induces activation of multiple tyrosine kinases, resulting in phosphorylation of numerous intracellular substrates.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
23	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
24	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10333
# text = One substrate is p95vav, which is expressed exclusively in hematopoietic and trophoblast cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	exclusively	exclusively	ADV	RB	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	trophoblast	trophoblast	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10334
# text = It contains a number of structural motifs, including Src homology 2, Src homology 3, and pleckstrin homology domains and a putative guanine nucleotide exchange domain.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	number	number	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
7	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
10	Src	Src	PROPN	NNP	Number=Sing	_	_	_	_
11	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Src	Src	PROPN	NNP	Number=Sing	_	_	_	_
15	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	pleckstrin	pleckstrin	ADJ	JJ	Degree=Pos	_	_	_	_
20	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
21	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
25	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
26	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
27	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
28	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10335
# text = The role of p95vav in TCR-mediated signaling processes is unclear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
10	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10336
# text = Here, we show that overexpression of p95vav alone in Jurkat T cells leads to activation of the nuclear factors, including NFAT, involved in interleukin-2 expression.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
9	alone	alone	ADV	RB	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	NFAT	Nfat	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10337
# text = Furthermore, p95vav synergizes with TCR stimulation in inducing NFAT- and interleukin-2-dependent transcription.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	p95vav	p95vave	VERB	VBP	Abbr=Yes|Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	synergizes	synergize	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10338
# text = In contrast, NFAT activation by a G-protein-coupled receptor is not modulated by p95vav overexpression, suggesting that the effect is specific to the TCR signaling pathways.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	protein-	protein-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
17	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
28	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
29	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10339
# text = Although removal of the first 67 amino acids of p95vav activates its transforming potential in NIH 3T3 cells, this region appears to be required for its function in T cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	67	67	NUM	CD	NumType=Card	_	_	_	_
7	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
8	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
11	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
14	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	NIH	Nih	PROPN	NNP	Number=Sing	_	_	_	_
17	3T3	3T3	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10340
# text = We further demonstrate that the p95vav-induced NFAT activation is not mimicked by Ras activation, though its function is dependent upon Ras and Raf.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	though	though	SCONJ	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	function	function	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	upon	upon	ADP	IN	_	_	_	_	_
24	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10341
# text = Furthermore, the activating function of p95vav is blocked by FK506, suggesting that its activity also depends on calcineurin.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p95vav	p95vav	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10342
# text = To further dissect p95vav involvement in TCR signaling, we analyzed various Jurkat mutants deficient in TCR signaling function or TCR expression and showed that an intact TCR signaling pathway is required for p95vav to function.
1	To	to	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	dissect	dissect	NOUN	NN	Number=Sing	_	_	_	_
4	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
15	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
28	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
29	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	function	function	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10343
# text = However, overexpression of p95vav does not appear to influence TCR-induced protein tyrosine phosphorylation or increases in cytoplasmic free calcium.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p95vav	p95vav	NOUN	NN	Number=Sing	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
11	TCR	Tcr	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
21	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
22	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10344
# text = Taken together, our data suggest that p95vav plays an important role at an yet unidentified proximal position in the TCR signaling cascade.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	p95vav	p95vave	NOUN	NN	Number=Sing	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	yet	yet	ADV	RB	_	_	_	_	_
16	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	position	position	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
23	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10345
# text = Document 0030012169 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012169	0030012169	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10346
# text = Transcription factors in immune-mediated disease.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	immune-mediated	immune-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
5	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10347
# text = A large amount of detailed information about the intracellular proteins regulating NF-kappa B activation and the cellular response to NF-kappa B activation has emerged recently.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
3	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	detailed	detailed	ADJ	JJ	Degree=Pos	_	_	_	_
6	information	information	NOUN	NN	Number=Sing	_	_	_	_
7	about	about	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	emerged	emerge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10348
# text = Several small molecules, an antisense oligonucleotide, and gene therapeutic agents that inhibit NF-kappa b activation have been described.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
7	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	b	b	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10349
# text = Despite this, there are still significant gaps in our understanding of this process and its consequences.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	there	there	PRON	EX	_	_	_	_	_
5	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	still	still	ADV	RB	_	_	_	_	_
7	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
8	gaps	gap	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
11	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	process	process	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	consequences	consequences	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10350
# text = In contrast, the characterization of transcription factors selectively regulating cytokine production by CD4+ T cell subsets is at a very early stage.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	very	very	ADV	RB	_	_	_	_	_
23	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
24	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10351
# text = Three interacting proteins have recently been shown to contribute to subset-restricted expression of the IL-4 gene.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	interacting	interacting	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	recently	recently	ADV	RB	_	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	subset	subset	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
12	-restricted	-restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10352
# text = There are other elements regulating IL-4 gene expression, however, and the relative importance of these recently identified proteins has yet to be determined.
1	There	there	PRON	EX	_	_	_	_	_
2	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
17	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	recently	recently	ADV	RB	_	_	_	_	_
21	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	yet	yet	ADV	RB	_	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10353
# text = Document 0030012174 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012174	0030012174	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10354
# text = Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
1	Separation	separation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	redox	redox	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10355
# text = Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate) individually initiate signaling.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	begins	begin	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
17	series	series	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	stimuli-specific	stimuli-specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
34	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	mitomycin	mitomycin	NOUN	NN	Number=Sing	_	_	_	_
37	C	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
42	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
45	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
47	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
48	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
50	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	individually	individually	ADV	RB	_	_	_	_	_
53	initiate	initiate	ADJ	JJ	Degree=Pos	_	_	_	_
54	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10356
# text = These initial pathways culminate in a common pathway through which all of the stimulating agents ultimately signal NF-kappa B activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	culminate	culminate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
16	ultimately	ultimately	ADV	RB	_	_	_	_	_
17	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10357
# text = We distinguish the stimuli-specific pathways by showing that the oxidative stimuli trigger NF-kappa B activation in only one of two human T-cell lines (Wurzburg but not Jurkat), whereas tumor necrosis factor alpha and phorbol 12-myristate 13-acetate readily stimulate in both lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	distinguish	distinguish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	stimuli-specific	stimuli-specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
12	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Wurzburg	Wurzburg	PROPN	NNP	Number=Sing	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	ADV	RB	_	_	_	_	_
31	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	whereas	whereas	SCONJ	IN	_	_	_	_	_
35	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
36	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
41	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
43	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
44	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
47	readily	readily	ADV	RB	_	_	_	_	_
48	stimulate	stimulate	ADV	RB	Degree=Pos	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	both	both	DET	DT	_	_	_	_	_
51	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10358
# text = We propose the common pathway as the simplest way of accounting for the common requirements and properties of the signaling pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	simplest	simplest	ADJ	JJS	Degree=Sup	_	_	_	_
9	way	way	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	accounting	accounte	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
15	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10359
# text = We include a redox-regulatory mechanism(s) in this common pathway to account for the previously demonstrated redox regulation of NF-kappa B activation in Jurkat cells (in which oxidants don't activate NF-kappa B); we put tyrosine phosphorylation in the common pathway by showing that kinase activity (inhibitable by herbimycin A and tyrphostin 47) is required for NF-kappa B activation by all stimuli tested in both cell lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	redox	redox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	s	s	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	previously	previously	ADV	RB	_	_	_	_	_
20	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	in	in	ADP	IN	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	_
36	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
37	n't	not	PART	RB	_	_	_	_	_
38	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
39	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	;	;	PUNCT	,	_	_	_	_	_
45	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
46	put	put	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
48	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
52	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
53	by	by	SCONJ	IN	_	_	_	_	_
54	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
55	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
57	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	inhibitable	inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
60	by	by	ADP	IN	_	_	_	_	_
61	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
62	A	a	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	tyrphostin	tyrphostin	NOUN	NN	Number=Sing	_	_	_	_
65	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
66	)	)	PUNCT	-RRB-	_	_	_	_	_
67	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
68	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
69	for	for	ADP	IN	_	_	_	_	_
70	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
72	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
73	B	b	NOUN	NN	Number=Sing	_	_	_	_
74	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
75	by	by	ADP	IN	_	_	_	_	_
76	all	all	DET	DT	_	_	_	_	_
77	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
78	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
79	in	in	ADP	IN	_	_	_	_	_
80	both	both	DET	DT	_	_	_	_	_
81	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
82	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
83	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10360
# text = Since internal sites of oxidant production have been shown to play a key role in the cytokine-stimulated activation of NF-kappa B, and since tyrosine kinase and phosphatase activities are known to be altered by oxidants, these findings suggest that intracellular redox status controls NF-kappa B activation by regulating tyrosine phosphorylation event(s) within the common step of the NF-kappa B signal transduction pathway.
1	Since	since	ADP	IN	_	_	_	_	_
2	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	since	since	SCONJ	IN	_	_	_	_	_
29	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
33	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
38	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
44	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	that	that	SCONJ	IN	_	_	_	_	_
46	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
47	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
48	status	status	NOUN	NN	Number=Sing	_	_	_	_
49	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
50	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
53	B	b	NOUN	NN	Number=Sing	_	_	_	_
54	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
55	by	by	SCONJ	IN	_	_	_	_	_
56	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
57	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
58	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
59	event	event	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	s	s	X	AFX	_	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	within	within	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
66	step	step	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
69	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
72	B	b	NOUN	NN	Number=Sing	_	_	_	_
73	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
74	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
75	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10361
# text = Document 0030012180 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012180	0030012180	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10362
# text = CD30 ligation induces nuclear factor-kappa B activation in human T cell lines.
1	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
2	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10363
# text = CD30 is a recently described member of the tumor necrosis factor/nerve growth factor receptor superfamily.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	recently	recently	ADV	RB	_	_	_	_	_
5	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	member	member	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	nerve	nerve	NOUN	NN	Number=Sing	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10364
# text = In this report, we show that following incubation of L540 cells (Hodgkin's disease-derived, T cell-like, CD30+ cells) with the agonistic anti-CD30 monoclonal antibodies (mAb) M44 and M67, two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts, as determined in gel retardation assays.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	L540	L540	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	's	's	PART	POS	_	_	_	_	_
16	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	like	like	INTJ	UH	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	agonistic	agonistic	ADJ	JJ	Degree=Pos	_	_	_	_
32	anti-CD30	anti-CD30	NUM	CD	NumType=Card	_	_	_	_
33	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
34	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	M44	m44	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	M67	M67	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	two	two	NUM	CD	NumType=Card	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
50	B	b	NOUN	NN	Number=Sing	_	_	_	_
51	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
52	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
53	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
54	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
58	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	as	as	SCONJ	IN	_	_	_	_	_
61	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
64	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
65	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10365
# text = The effect of the mAb towards NF-kappa B activation was rapid, as it occurred within 20 min, and was sustained for up to 6 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
6	towards	towards	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	20	20	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	up	up	ADV	RB	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10366
# text = By comparison, an isotype-matched antibody had no effect on NF-kappa B activation.
1	By	by	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	isotype-matched	isotype-matched	ADJ	JJ	Degree=Pos	_	_	_	_
6	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10367
# text = Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, < 1% und 93% CD30+, respectively), the extent of CD30-mediated NF-kappa B activation correlated with the proportion of CD30+ cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Th	th	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
11	functionally	functionally	ADV	RB	_	_	_	_	_
12	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	0	0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	28	28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	<	<	PUNCT	-LRB-	_	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	_
32	und	und	ADJ	JJ	Degree=Pos	_	_	_	_
33	93	93	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	%	%	SYM	NN	Number=Sing	_	_	_	_
35	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
50	B	b	NOUN	NN	Number=Sing	_	_	_	_
51	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
52	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	+	+	SYM	SYM	_	_	_	_	_
59	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10368
# text = In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1, p65 RelA, and possibly other transcription factors.
1	In	in	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
16	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
21	p50	p50	NUM	CD	NumType=Card	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B1	b1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	p65	p65	NUM	CD	NumType=Card	_	_	_	_
28	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	possibly	possibly	ADV	RB	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10369
# text = Collectively, our results demonstrate that nuclear translocation and activation of NF-kappa B rank among the short-term cellular responses elicited following CD30 ligation.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	rank	rank	NOUN	NN	Number=Sing	_	_	_	_
17	among	among	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	term	term	NOUN	NN	Number=Sing	_	_	_	_
22	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_
23	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
24	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
27	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10370
# text = Document 0030012181 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012181	0030012181	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10371
# text = Downregulation of Wilms' tumor gene (WT1) is not a prerequisite for erythroid or megakaryocytic differentiation of the leukemic cell line K562.
1	Downregulation	Downregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Wilms	Wilm	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
4	'	's	PART	POS	_	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	WT1	WT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	prerequisite	prerequisite	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	K562	k562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10372
# text = The Wilms' tumor gene (WT1) encodes a transcription factor of the zinc finger type.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Wilms	Wilm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	'	's	PART	POS	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	WT1	wt1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
16	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10373
# text = A high expression of WT1 has been detected in a range of acute leukemias, and WT1 is downregulated during induced differentiation of some leukemic cell lines.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	range	range	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	some	some	DET	DT	_	_	_	_	_
25	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10374
# text = Overexpression of WT1 in some myeloid cell lines confers resistance to differentiation induction.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	some	some	DET	DT	_	_	_	_	_
6	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
10	resistance	resistance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10375
# text = These observations suggest that a high WT1 expression in hematopoietic cells is incompatible with differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	WT1	wt1	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	incompatible	incompatible	ADJ	JJ	Degree=Pos	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10376
# text = In this study, each of the four different isoforms of WT1 was constitutively overexpressed in the leukemic cell line K562.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	each	each	DET	DT	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	four	four	NUM	CD	NumType=Card	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	constitutively	constitutively	ADV	RB	_	_	_	_	_
15	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	K562	K562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10377
# text = K562 cells express endogenous WT1, which is downregulated as a response to induced differentiation along the erythroid and megakaryocytic pathways.
1	K562	K562	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
5	WT1	wt1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	along	along	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10378
# text = We now demonstrate that a forced exogenous expression of the four different isoforms of WT1 in K562 does not affect the differentiation response, as judged by accumulation of hemoglobin in response to hemin or the expression of megakaryocytic cell surface markers in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	forced	force	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	four	four	NUM	CD	NumType=Card	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	K562	K562	NUM	CD	NumType=Card	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	hemin	hemin	VERB	VB	VerbForm=Inf	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
42	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	response	response	NOUN	NN	Number=Sing	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	O	of	INTJ	UH	_	_	_	_	SpaceAfter=No
49	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
50	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10379
# text = We conclude that downregulation of WT1 during induced differentiation of K562 cells is not a prerequisite for erythroid or megakaryocytic differentiation of these cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	WT1	WT1	NUM	CD	NumType=Card	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	K562	K562	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	prerequisite	prerequisite	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10380
# text = Document 0030012183 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012183	0030012183	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10381
# text = A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p75	p75	NUM	CD	NumType=Card	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	p75TNF	p75TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
18	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	lymphotoxin	lymphotoxin	ADP	IN	_	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	p55TNF	p55TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10382
# text = Despite overwhelming evidence that enhanced production of the p75 tumor necrosis factor receptor (p75TNF-R) accompanies development of specific human inflammatory pathologies such as multi-organ failure during sepsis, inflammatory liver disease, pancreatitis, respiratory distress syndrome, or AIDS, the function of this receptor remains poorly defined in vivo.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	overwhelming	overwhelming	ADJ	JJ	Degree=Pos	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	p75	p75	NUM	CD	NumType=Card	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	p75TNF	p75tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	R	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	accompanies	accompany	NOUN	NNS	Number=Plur	_	_	_	_
20	development	development	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathologies	pathology	NOUN	NNS	Number=Plur	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	multi-organ	multi-organ	ADJ	JJ	Degree=Pos	_	_	_	_
29	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
30	during	during	ADP	IN	_	_	_	_	_
31	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
34	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
35	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	pancreatitis	pancreatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	respiratory	respiratory	ADJ	JJ	Degree=Pos	_	_	_	_
40	distress	distress	NOUN	NN	Number=Sing	_	_	_	_
41	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	function	function	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
50	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
51	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
52	poorly	poorly	ADV	RB	_	_	_	_	_
53	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10383
# text = We show here that at levels relevant to human disease, production of the human p75TNF-R in transgenic mice results in a severe inflammatory syndrome involving mainly the pancreas, liver, kidney, and lung, and characterized by constitutively increased NF-kappaB activity in the peripheral blood mononuclear cell compartment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	p75TNF	p75TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	R	R	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
21	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
22	results	result	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
28	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
29	mainly	mainly	ADV	RB	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	pancreas	pancrea	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	liver	liver	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	constitutively	constitutively	ADV	RB	_	_	_	_	_
44	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
48	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
52	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
53	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
54	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
55	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10384
# text = This process is shown to evolve independently of the presence of TNF, lymphotoxin alpha, or the p55TNF-R, although coexpression of a human TNF transgene accelerated pathology.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	process	process	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	evolve	evolve	VERB	VB	VerbForm=Inf	_	_	_	_
7	independently	independently	ADV	RB	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	lymphotoxin	lymphotoxin	ADP	IN	_	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	p55TNF	p55tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	R	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	although	although	SCONJ	IN	_	_	_	_	_
24	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
29	transgene	transgene	PRON	PRP	_	_	_	_	_
30	accelerated	accelerate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	pathology	pathology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10385
# text = These results establish an independent role for enhanced p75TNF-R production in the pathogenesis of inflammatory disease and implicate the direct involvement of this receptor in a wide range of human inflammatory pathologies.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	p75TNF	p75tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	R	r	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	implicate	implicate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
23	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
30	range	range	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
34	pathologies	pathology	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10386
# text = Document 0030012196 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012196	0030012196	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10387
# text = A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	Ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	human	human	VERB	VB	VerbForm=Inf	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
27	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10388
# text = Human immunodeficiency virus type 1 (HIV-1) and HIV-2 are structurally related retroviruses which both cause AIDS in humans.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	structurally	structurally	ADV	RB	_	_	_	_	_
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
22	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10389
# text = Although both viruses establish latency in quiescent human-peripheral-blood T cells, the asymptomatic phase of HIV-2 infection may be more prolonged than that of HIV-1.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
4	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	T	t	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	asymptomatic	asymptomatic	ADJ	JJ	Degree=Pos	_	_	_	_
18	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	more	more	ADV	RBR	_	_	_	_	_
27	prolonged	prolong	ADJ	JJ	Degree=Pos	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10390
# text = The latent phases of both HIV-1 and HIV-2 infection have been shown to be disrupted by T-cell activation, a process that requires host cell transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
3	phases	phase	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	disrupted	disrupt	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	process	process	NOUN	NN	Number=Sing	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	host	host	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10391
# text = In the case of HIV-1, the transcription factor NF-kappa B is sufficient for inducible transcriptional activation.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	case	case	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10392
# text = In contrast, factors in addition to NF-kappa B are required to activate HIV-2 transcription in infected T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10393
# text = In this report, we demonstrate that a novel Ets-related transcription factor, Elf-1, binds specifically to two purine-rich motifs in the HIV-2 enhancer.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	Ets-	Ets-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
20	specifically	specifically	ADV	RB	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
26	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10394
# text = Mutagenesis experiments demonstrated that these Elf-1 binding sites are required for induction of HIV-2 transcription following T-cell-receptor-mediated T-cell activation.
1	Mutagenesis	Mutagenesis	PROPN	NNP	Number=Sing	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	Elf	Elf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	T-cell	T-cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	receptor-mediated	receptor-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10395
# text = Moreover, Elf-1 is the only factor present in activated T-cell nuclear extracts that binds to these sites in electrophoretic mobility shift assays.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
24	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10396
# text = Thus, Elf-1 is a novel transcription factor that appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10397
# text = These results may explain differences in the clinical spectra of diseases caused by HIV-1 and HIV-2 and may also have implications for the design of therapeutic approaches to HIV-2 infection.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	spectra	spectra	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
12	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
25	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	design	design	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
31	approaches	approache	NOUN	NNS	Number=Plur	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10398
# text = Document 0030012198 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012198	0030012198	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10399
# text = A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	3	3	NUM	CD	NumType=Card	_	_	_	_
12	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	cooperatively	cooperatively	ADV	RB	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10400
# text = Interleukin-3 (IL-3) is a cytokine that is expressed primarily in activated T cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	primarily	primarily	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10401
# text = Here we identified an inducible T cell-specific enhancer 14 kb upstream of the IL-3 gene that responded to activation of T cell receptor signaling pathways.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	T	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	14	14	NUM	CD	NumType=Card	_	_	_	_
12	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
13	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
29	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10402
# text = The IL-3 enhancer spanned an inducible cyclosporin A-sensitive DNase I-hypersensitive site found only in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	3	3	NUM	CD	NumType=Card	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	spanned	span	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
10	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10403
# text = Four NFAT-like elements exist within the enhancer.
1	Four	Four	PROPN	NNP	Number=Sing	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	like	like	SCONJ	IN	_	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	exist	exist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10404
# text = The two most active NFAT-like elements were located at the center of the DNase I-hypersensitive site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	most	most	ADV	RBS	_	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	like	like	SCONJ	IN	_	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	center	center	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10405
# text = One of these NFAT-like elements encompassed overlapping Oct- and NFATp/c-binding sites, which functioned in a highly synergistic manner.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	like	like	SCONJ	IN	_	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	encompassed	encompass	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	overlapping	overlapp	VERB	VBG	VerbForm=Ger	_	_	_	_
10	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NFATp/c	NFATp/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-binding	-binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	functioned	function	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	highly	highly	ADV	RB	_	_	_	_	_
22	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10406
# text = We suggest that the T cell-specific expression of the IL-3 gene is partly controlled through the enhancer by cooperation between Oct and NFAT family proteins.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	partly	partly	ADV	RB	_	_	_	_	_
18	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10407
# text = Document 0030012203 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012203	0030012203	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10408
# text = An allosteric drug, o,o'-bismyristoyl thiamine disulfide, suppresses HIV-1 replication through prevention of nuclear translocation of both HIV-1
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	allosteric	allosteric	ADJ	JJ	Degree=Pos	_	_	_	_
3	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	o	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
7	o	of	ADV	RB	_	_	_	_	SpaceAfter=No
8	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
9	bismyristoyl	bismyristoyl	ADJ	JJ	Degree=Pos	_	_	_	_
10	thiamine	thiamine	NOUN	NN	Number=Sing	_	_	_	_
11	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 10409
# text = Tat and NF-kappa B.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10410
# text = The efficacy of o,o'-bismyristoyl thiamine disulfide (BMT) was examined in detail against HIV-1 laboratory isolates (HTLV-IIIB, JRFL, and MN), primary isolates (KMT and KMO), and simian immunodeficiency virus (SIVmac251) in vitro.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	o	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
6	o	of	ADV	RB	_	_	_	_	SpaceAfter=No
7	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
8	bismyristoyl	bismyristoyl	ADJ	JJ	Degree=Pos	_	_	_	_
9	thiamine	thiamine	NOUN	NN	Number=Sing	_	_	_	_
10	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	BMT	BMT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	detail	detail	NOUN	NN	Number=Sing	_	_	_	_
18	against	against	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
23	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-IIIB	-IIIB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	JRFL	JRFL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	MN	MN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
35	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	KMT	KMT	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	KMO	KMO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
44	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
45	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	SIVmac251	SIVmac251	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10411
# text = BMT inhibited the replication of HIV-1 in both laboratory and primary isolates in vitro.
1	BMT	BMT	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
14	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10412
# text = In addition, BMT exhibited antiviral activity against SIVmac251.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	BMT	BMT	PROPN	NNP	Number=Sing	_	_	_	_
5	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	against	against	ADP	IN	_	_	_	_	_
9	SIVmac251	SIVmac251	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10413
# text = Minimizing energy studies of BMT structure reveal that a trans-disulfide of thiamine (holo drug) disulfide (TDS, protodrug) is allosterically transited to the reactive twisted disulfide of BMT (allo drug) by o,o'-bismyristoyl esterification of TDS.
1	Minimizing	minimizing	VERB	VBG	VerbForm=Ger	_	_	_	_
2	energy	energy	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	BMT	Bmt	ADJ	JJ	Degree=Pos	_	_	_	_
6	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
7	reveal	reveal	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	trans	tran	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	thiamine	thiamine	PRON	PRP	_	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	holo	holo	X	AFX	_	_	_	_	_
17	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	TDS	tds	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	protodrug	protodrug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	allosterically	allosterically	ADV	RB	_	_	_	_	_
27	transited	transit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
31	twisted	twist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	BMT	BMT	PROPN	NNP	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	allo	allo	X	AFX	_	_	_	_	_
37	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	o	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
42	o	of	ADV	RB	_	_	_	_	SpaceAfter=No
43	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
44	bismyristoyl	bismyristoyl	ADJ	JJ	Degree=Pos	_	_	_	_
45	esterification	esterification	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	TDS	TDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10414
# text = BMT inhibits nuclear translocation of both HIV-1 transactivator (TAT) and the cellular transcriptional nuclear factor-KB (NF-kappa B), resulting in the suppression of HIV-1 replication.
1	BMT	Bmt	ADJ	JJS	Degree=Sup	_	_	_	_
2	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TAT	TAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	KB	KB	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10415
# text = Document 0030012206 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012206	0030012206	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10416
# text = Activation of nuclear factor kappa B in human lymphoblastoid cells by low-dose ionizing radiation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
15	ionizing	ionizing	NOUN	NN	Number=Sing	_	_	_	_
16	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10417
# text = Nuclear factor kappa B (NF-kappa B) is a pleiotropic transcription factor which is involved in the transcriptional regulation of several specific genes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10418
# text = Recent reports demonstrated that ionizing radiation in the dose range of 2-50 Gy results in expression of NF-kappa B in human KG-1 myeloid leukemia cells and human B-lymphocyte precursor cells; the precise mechanism involved and the significance are not yet known.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ionizing	ionize	VERB	VBG	VerbForm=Ger	_	_	_	_
6	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
10	range	range	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	2-	2-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	50	50	NUM	CD	NumType=Card	_	_	_	_
14	Gy	Gy	ADJ	JJ	Degree=Pos	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	KG	kg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
29	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
36	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	;	;	PUNCT	,	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
41	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
42	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	not	not	PART	RB	_	_	_	_	_
48	yet	yet	ADV	RB	_	_	_	_	_
49	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10419
# text = The present report demonstrates that even lower doses of ionizing radiation, 0.25-2.0
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	even	even	ADV	RB	_	_	_	_	_
7	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
8	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	ionizing	ionizing	VERB	VBG	VerbForm=Ger	_	_	_	_
11	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	0.25	0.25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	2.0	2.0	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 10420
# text = Gy, are capable of inducing expression of NF-kappa B in EBV-transformed 244B human lymphoblastoid cells.
1	Gy	Gy	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
5	of	of	SCONJ	IN	_	_	_	_	_
6	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	244B	244b	PROPN	NNP	Number=Sing	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10421
# text = These results are in a dose range where the viability of the cells remains very high.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
7	range	range	NOUN	NN	Number=Sing	_	_	_	_
8	where	where	ADV	WRB	PronType=Rel	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	viability	viability	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	very	very	ADV	RB	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10422
# text = After exposure to 137Cs gamma rays at a dose rate of 1.17 Gy/min, a maximum in expression of NF-kappa B was seen at 8 h after a 0.5-Gy exposure.
1	After	after	ADP	IN	_	_	_	_	_
2	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	137C	137C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	s	's	PART	POS	_	_	_	_	_
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	rays	ray	NOUN	NNS	Number=Plur	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
11	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	1.17	1.17	NUM	CD	NumType=Card	_	_	_	_
14	Gy/min	Gy/min	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	maximum	maximum	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	8	8	NUM	CD	NumType=Card	_	_	_	_
29	h	h	NOUN	NN	Number=Sing	_	_	_	_
30	after	after	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	0.5	0.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	Gy	Gy	NOUN	NN	Number=Sing	_	_	_	_
35	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10423
# text = Time-course studies revealed a biphasic time-dependent expression after 0.5-, 1- and 2-Gy exposures.
1	Time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	course	course	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
8	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	0.5	0.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Gy	Gy	NOUN	NN	Number=Sing	_	_	_	_
22	exposures	exposure	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10424
# text = However, for each time examined, the expression of NF-kappa B was maximum after the 0.5-Gy exposure.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	each	each	DET	DT	_	_	_	_	_
5	time	time	NOUN	NN	Number=Sing	_	_	_	_
6	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	0.5	0.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Gy	Gy	NOUN	NN	Number=Sing	_	_	_	_
22	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10425
# text = The expression of the p50 and p65 NF-kappa B subunits was also shown to be regulated differentially after exposures to 1.0 and 2.0 Gy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p65	p65	NUM	CD	NumType=Card	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	differentially	differentially	ADV	RB	_	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	exposures	exposure	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	1.0	1.0	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	2.0	2.0	NUM	CD	NumType=Card	_	_	_	_
26	Gy	Gy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10426
# text = Document 0030012208 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012208	0030012208	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10427
# text = Interleukin-10 stabilizes inhibitory kappaB-alpha in human monocytes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	stabilizes	stabilize	NOUN	NNS	Number=Plur	_	_	_	_
5	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10428
# text = Interleukin-10 (IL-10) protects animals from lethal endotoxemia.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-10	-10	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	protects	protect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	lethal	lethal	ADJ	JJ	Degree=Pos	_	_	_	_
12	endotoxemia	endotoxemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10429
# text = This beneficial effect is mediated, in part, by inhibition of inflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
19	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10430
# text = Evidence suggests that IL-10 may inhibit activation of the transcription factor nuclear factor-kappaB (NF-kappaB) through an unknown mechanism.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-kappaB	-kappaB	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10431
# text = NF-kappaB activation in response to inflammatory signals is dependent upon degradation of its associated inhibitory peptide, inhibitory kappaB-alpha (IkappaB-alpha).
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	upon	upon	ADP	IN	_	_	_	_	_
13	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
18	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
21	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IkappaB-	Ikappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10432
# text = We hypothesized that IL-10 prevents human monocyte NF-kappaB activation and resultant TNF-alpha production by stabilization of IkappaB-alpha.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	resultant	resultant	NOUN	NN	Number=Sing	_	_	_	_
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IkappaB-	Ikappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10433
# text = The purpose of this study was to determine the effect of IL-10 on lipopolysaccharide (LPS)-induced human monocyte TNF-alpha production, NF-kappaB activation, and IkappaB-alpha degradation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
24	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10434
# text = Monocytes were isolated from human donors.
1	Monocytes	Monocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10435
# text = Cells were stimulated with endotoxin (LPS, 100 ng/mL) with and without human IL-10 (10 ng/mL).
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	100	100	NUM	CD	NumType=Card	_	_	_	_
10	ng/	ng/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
11	mL	mL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	without	without	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	IL-10	IL-10	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	10	10	NUM	CD	NumType=Card	_	_	_	_
20	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	mL	mL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10436
# text = Following stimulation, TNF-alpha was measured in cell supernatants by ELISA, NF-kappaB activity by electrophoretic mobility shift assay, and IkappaB-alpha levels by Western blot.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
21	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
22	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
23	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
32	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10437
# text = We observed that after LPS stimulation of human monocytes, TNF-alpha increased to 798+/-67 pg/mL (p < .001 versus control).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
14	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	798+/-67	798+/-67	NUM	CD	NumType=Card	_	_	_	_
17	pg/mL	pg/mL	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	p	p	NOUN	NN	Number=Sing	_	_	_	_
20	<	<	PUNCT	-LRB-	_	_	_	_	_
21	.001	.001	NUM	CD	NumType=Card	_	_	_	_
22	versus	versus	ADJ	JJ	Degree=Pos	_	_	_	_
23	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10438
# text = IL-10 attenuated LPS-stimulated TNF-alpha production (297+/-54; p < .001 versus LPS alone).
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	297+/-54	297+/-54	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	p	p	NOUN	NN	Number=Sing	_	_	_	_
16	<	<	PUNCT	-LRB-	_	_	_	_	_
17	.001	.001	NUM	CD	NumType=Card	_	_	_	_
18	versus	versus	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
20	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10439
# text = After LPS stimulation in human monocytes, IkappaB-alpha protein levels decreased, and NF-kappaB DNA binding increased.
1	After	after	ADP	IN	_	_	_	_	_
2	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10440
# text = IL-10 pretreatment prevented LPS-induced decreases in IkappaB-alpha protein levels and attenuated NF-kappaB DNA binding.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
5	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10441
# text = IL-10 appears to prevent activation of NF-kappaB by preserving IkappaB-alpha protein levels, leading to a reduction in TNF-alpha release.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	preserving	preserve	VERB	VBG	VerbForm=Ger	_	_	_	_
14	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	alpha	alpha	ADP	IN	_	_	_	_	_
28	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10442
# text = Document 0030012212 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012212	0030012212	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10443
# text = Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
3	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	markedly	markedly	ADV	RB	_	_	_	_	_
6	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10444
# text = Although many functions of human alveolar macrophages are altered compared with their precursor cell, the blood monocyte (monocyte), the reason(s) for these functional changes have not been determined.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	reason	reason	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	s	s	X	AFX	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
31	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
32	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	determined	determin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10445
# text = We recently reported that human alveolar macrophages do not express AP-1 DNA binding activity (Monick, M. M., Carter, A. B., Gudmundsson, G., Geist, L. J., and Hunninghake, G. W. (1998)
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	recently	recently	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	Monick	Monick	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
21	M.	M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Carter	Carter	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	A.	A.	PROPN	NNP	Number=Sing	_	_	_	_
26	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Gudmundsson	Gudmundsson	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	G.	G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	Geist	Geist	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
35	J.	J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	Hunninghake	Hunninghake	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	G.	G.	PROPN	NNP	Number=Sing	_	_	_	_
41	W.	W.	PROPN	NNP	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	1998	1998	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 10446
# text = Am.
1	Am	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10447
# text = J. Physiol. 275, L389-L397).
1	J.	J.	PROPN	NNP	Number=Sing	_	_	_	_
2	Physiol	Physiol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_
4	275	275	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	L389-	l389-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	L397	L397	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10448
# text = To determine why alveolar macrophages do not express AP-1 DNA binding activity, we first showed that there was not a decrease in expression of the FOS and JUN proteins that make up the AP-1 complex.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	why	why	ADV	WRB	PronType=Int	_	_	_	_
4	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
5	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
6	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	first	first	ADV	RB	_	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	there	there	PRON	EX	_	_	_	_	_
21	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	FOS	Fo	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	JUN	Jun	ADJ	JJ	Degree=Pos	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	make	make	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	up	up	ADP	RP	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10449
# text = There was, however, a significant difference in the amounts of the nuclear protein, REF-1 (which regulates AP-1 DNA binding by altering the redox status of FOS and JUN proteins), in alveolar macrophages compared with monocytes.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
8	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	by	by	SCONJ	IN	_	_	_	_	_
29	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
32	status	status	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	FOS	FOS	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	JUN	JUN	PROPN	NNP	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
42	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
43	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10450
# text = In addition, in vitro differentiation of monocytes to a macrophage-like cell resulted in decreased amounts of REF-1.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10451
# text = Finally, addition of REF-1 from activated monocytes to alveolar macrophage nuclear proteins resulted in a marked increase in AP-1 DNA binding.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	alveolar	alveolar	VERB	VB	VerbForm=Inf	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10452
# text = These studies strongly suggest that the process of differentiation of monocytes into alveolar macrophages is associated with a loss of REF-1 and AP-1 activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	process	process	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	REF	REF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10453
# text = This observation may explain, in part, some of the functional differences observed for alveolar macrophages compared with monocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	some	some	DET	DT	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10454
# text = Document 0030012213 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012213	0030012213	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10455
# text = Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus.
1	Control	Control	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
5	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10456
# text = Infection of human B cells with Epstein-Barr virus (EBV) results in activation of the cell cycle and cell growth.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10457
# text = To interpret the mechanisms by which EBV activates the cell, we have assayed many proteins involved in control of the G0 and G1 phases of the cell cycle and regulation of apoptosis.
1	To	to	PART	TO	_	_	_	_	_
2	interpret	interpret	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	G0	G0	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	G1	G1	NUM	CD	NumType=Card	_	_	_	_
25	phases	phasis	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10458
# text = In EBV infection most of the changes, including the early induction of cyclin D2, are dependent on expression of EBV genes, but an alteration in the E2F-4 profile was partly independent of viral gene expression, presumably occurring in response to signal transduction activated when the virus binds to its receptor, CD21.
1	In	in	ADP	IN	_	_	_	_	_
2	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
3	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
4	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
15	D2	d2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	partly	partly	ADV	RB	_	_	_	_	_
36	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	presumably	presumably	ADV	RB	_	_	_	_	_
43	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	response	response	NOUN	NN	Number=Sing	_	_	_	_
46	to	to	PART	TO	_	_	_	_	_
47	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
48	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
49	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
50	when	when	ADV	WRB	PronType=Int	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
53	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
54	to	to	ADP	IN	_	_	_	_	_
55	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
56	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	CD21	CD21	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10459
# text = By comparing the expression of genes controlling apoptosis, including those encoding several members of the BCL-2 family of proteins, the known relative resistance of EBV-immortalized B-cell lines to apoptosis induced by low serum was found to correlate with expression of both BCL-2 and A20.
1	By	by	SCONJ	IN	_	_	_	_	_
2	comparing	compare	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
8	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
11	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
12	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	members	member	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
27	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
41	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	to	to	PART	TO	_	_	_	_	_
45	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	both	both	DET	DT	_	_	_	_	_
50	BCL	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	2	2	NUM	CD	NumType=Card	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	A20	A20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10460
# text = A20 can be regulated by the NF-kappaB transcription factor, which is known to be activated by the EBV LMP-1 protein.
1	A20	A20	NOUN	NN	Number=Sing	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
22	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10461
# text = Quantitative assays demonstrated a direct temporal relationship between LMP-1 protein levels and active NF-kappaB during the time course of infection.
1	Quantitative	Quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
2	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
6	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
7	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	time	time	NOUN	NN	Number=Sing	_	_	_	_
22	course	course	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10462
# text = Document 0030012215 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012215	0030012215	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10463
# text = Induction of immediate early response genes by macrophage colony-stimulating factor in normal human monocytes.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
4	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10464
# text = A group of coordinately induced protooncogenes, cytoskeletal, and extracellular matrix genes have been termed immediate early response genes, and their induction has been associated with growth factor-stimulated cell proliferation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	group	group	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	coordinately	coordinately	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	protooncogenes	protooncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	cytoskeletal	cytoskeletal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	termed	term	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
18	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10465
# text = We have investigated the induction of these genes by macrophage-CSF (M-CSF) in human monocytes that do not proliferate in response to M-CSF but require the factor for optimal cell differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10466
# text = Normal human monocytes were isolated, carefully washed, and incubated for 36 to 48 h in fetal bovine serum-containing medium.
1	Normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	carefully	carefully	ADV	RB	_	_	_	_	_
8	washed	wash	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	36	36	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	48	48	NUM	CD	NumType=Card	_	_	_	_
16	h	h	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
19	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
20	serum-	serum-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
22	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10467
# text = At the end of this incubation the resting cells were stimulated with M-CSF, and RNA was isolated for analysis by Northern blotting.
1	At	at	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	end	end	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	resting	resting	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
25	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10468
# text = RNA from control resting cells contained low to undetectable levels of c-jun, fibronectin receptor, and actin mRNA.
1	RNA	RNa	ADP	IN	_	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	control	control	NOUN	NN	Number=Sing	_	_	_	_
4	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	low	low	ADV	RB	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	actin	actin	PROPN	NNP	Number=Sing	_	_	_	_
20	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10469
# text = Within 15 to 30 min of addition of M-CSF, however, there was a dramatic coordinate induction of these genes.
1	Within	within	ADP	IN	_	_	_	_	_
2	15	15	NUM	CD	NumType=Card	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	30	30	NUM	CD	NumType=Card	_	_	_	_
5	min	min	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	there	there	PRON	EX	_	_	_	_	_
16	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
19	coordinate	coordinate	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10470
# text = The c-jun gene expression was very transient and was not detectable by 60 min after M-CSF addition.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	60	60	NUM	CD	NumType=Card	_	_	_	_
15	min	min	NOUN	NNS	Number=Plur	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
19	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10471
# text = In contrast, the expression of actin and fibronectin receptor mRNA was more sustained, and the expression of these genes remained elevated at 24 to 48 h after M-CSF addition.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	actin	actin	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	more	more	ADV	RBR	_	_	_	_	_
14	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	24	24	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	48	48	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
32	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10472
# text = We also observed the induction of the myelomonocytic specific tyrosine kinase hck gene simultaneously with the other immediate early response genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	hck	hck	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10473
# text = The protein synthesis inhibitor cycloheximide did not block the induction of any of these genes, and in fact, super-induced the expression of c-jun and hck.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
4	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
5	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	any	any	DET	DT	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	super	super	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	hck	hck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10474
# text = Nuclear run on transcription of the c-jun, hck, and actin genes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	hck	hck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	actin	actin	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10475
# text = Therefore, in normal human monocytes M-CSF induces immediate early response genes without inducing cell proliferation.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	without	without	SCONJ	IN	_	_	_	_	_
16	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10476
# text = These genes may then play a role in altering the physiologic status of the cells in response to CSF.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
12	status	status	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10477
# text = Document 0030012216 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012216	0030012216	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10478
# text = An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	v-	v-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
9	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
10	light	light	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-chain	-chain	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10479
# text = Lymphoid cells transformed by Abelson murine leukemia virus have provided one of the classic models for study of early B-cell development and immunoglobulin rearrangement.
1	Lymphoid	Lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	Abelson	Abelson	PROPN	NNP	Number=Sing	_	_	_	_
6	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
7	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	classic	classic	ADJ	JJ	Degree=Pos	_	_	_	_
15	models	model	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	study	study	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	development	development	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
26	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10480
# text = Most of these cells have rearranged their heavy-chain locus but not their light chain genes, suggesting that an active v-abl protein interferes with this differentiation step.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
11	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	light	light	NOUN	NN	Number=Sing	_	_	_	_
16	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	v-	v-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	step	step	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10481
# text = To test this hypothesis, light-chain gene structure was examined in pre-B cells transformed by temperature-sensitive mutants of the Abelson virus and in derivatives that survive at the nonpermissive temperature because they express a human BCL-2 gene.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	light	light	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
15	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
22	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Abelson	Abelson	PROPN	NNP	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	survive	survive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nonpermissive	nonpermissive	ADJ	JJ	Degree=Pos	_	_	_	_
35	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	_
36	because	because	SCONJ	IN	_	_	_	_	_
37	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
38	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	BCL	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10482
# text = Our studies reveal that inactivation of the v-abl protein tyrosine kinase triggers high-frequency rearrangement of kappa and lambda light-chain genes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	v-	v-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-frequency	-frequency	NOUN	NN	Number=Sing	_	_	_	_
16	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_
21	light	light	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10483
# text = These events are accompanied by marked increases in the expression of RAG-1 and RAG-2 RNAs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	events	event	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	RAG	rag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	RNAs	RNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10484
# text = These increases occur in the absence of protein synthesis but are dependent on inactivation of the v-abl protein tyrosine kinase.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
3	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	v-	v-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10485
# text = As documented in the accompanying paper (Klug et al., this issue), an active v-abl protein also suppresses the activity of NF-kappa B/rel and expression controlled by the kappa intron enhancer.
1	As	as	SCONJ	IN	_	_	_	_	_
2	documented	document	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	accompanying	accompanying	NOUN	NN	Number=Sing	_	_	_	_
6	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Klug	Klug	X	ADD	_	_	_	_	_
9	et	et	X	FW	_	_	_	_	_
10	al.	al.	X	FW	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	issue	issue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
18	v-	v-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	intron	intron	ADP	IN	_	_	_	_	_
39	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10486
# text = Together these data demonstrate that the v-abl protein specifically interferes with light-chain gene rearrangement by suppressing at least two pathways essential for this stage of B-cell differentiation and suggest that tyrosine phosphorylation is important in regulating RAG gene expression.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	specifically	specifically	ADV	RB	_	_	_	_	_
11	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	light	light	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	at	at	ADV	RB	_	_	_	_	_
21	least	least	ADV	RBS	Degree=Sup	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
24	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
39	in	in	SCONJ	IN	_	_	_	_	_
40	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
41	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10487
# text = Document 0030012219 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012219	0030012219	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10488
# text = Concomitant downregulation of IgH 3' enhancer activity and c-myc expression in a plasmacytoma x fibroblast environment: implications for dysregulation of translocated c-myc.
1	Concomitant	Concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
2	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	'	PUNCT	``	_	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
16	x	x	SYM	SYM	_	_	_	_	_
17	fibroblast	fibroblast	NOUN	NN	Number=Sing	_	_	_	_
18	environment	environment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	myc	myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10489
# text = Regulation of immunoglobulin heavy chain (IgH) gene expression is controlled by a B cell-specific promoter, intronic enhancer and additional B cell-specific enhancer elements identified recently in the 3' end of the IgH locus.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
4	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
5	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	intronic	intronic	ADJ	JJ	Degree=Pos	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
31	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	recently	recently	ADV	RB	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	'	'	PUNCT	``	_	_	_	_	_
37	end	end	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
41	locus	locus	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10490
# text = One of the latter elements, the IgH 3' enhancer, is of particular interest: (1) it is B cell-specific and active only in late B cell development; (2) in rodent plasmacytomas and in some human Burkitt's lymphomas it is part of a locus control region (LCR) that is involved in deregulation of the c-myc oncogene as a result of translocation into the IgH locus; and (3) it has been implicated in the mechanisms that control
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	''	_	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
16	interest	interest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	1	1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
29	only	only	ADV	RB	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	2	2	X	LS	_	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	rodent	rodent	ADJ	JJ	Degree=Pos	_	_	_	_
41	plasmacytomas	plasmacytoma	NOUN	NNS	Number=Plur	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	some	some	DET	DT	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	's	's	PART	POS	_	_	_	_	_
48	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
49	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
50	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
51	part	part	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	locus	locus	ADJ	JJ	Degree=Pos	_	_	_	_
55	control	control	NOUN	NN	Number=Sing	_	_	_	_
56	region	region	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	_
60	that	that	PRON	WDT	PronType=Rel	_	_	_	_
61	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
62	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	deregulation	deregulation	NOUN	NN	Number=Sing	_	_	_	_
65	of	of	ADP	IN	_	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
68	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
69	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
70	as	as	ADP	IN	_	_	_	_	_
71	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
72	result	result	NOUN	NN	Number=Sing	_	_	_	_
73	of	of	ADP	IN	_	_	_	_	_
74	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
75	into	into	ADP	IN	_	_	_	_	_
76	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
77	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
78	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
79	;	;	PUNCT	,	_	_	_	_	_
80	and	and	CCONJ	CC	_	_	_	_	_
81	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
82	3	3	X	LS	_	_	_	_	SpaceAfter=No
83	)	)	PUNCT	-RRB-	_	_	_	_	_
84	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
85	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
86	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
87	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
88	in	in	ADP	IN	_	_	_	_	_
89	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
90	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
91	that	that	PRON	WDT	PronType=Rel	_	_	_	_
92	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_

# sent_id = 10491
# text = Ig gene class switch recombination.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
3	class	class	NOUN	NN	Number=Sing	_	_	_	_
4	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
5	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10492
# text = We have used a somatic cell hybridization approach to genetically analyse regulation of the activity of the IgH 3' enhancer.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
8	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	genetically	genetically	ADV	RB	_	_	_	_	_
11	analyse	analyse	VERB	VB	VerbForm=Inf	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'	'	PUNCT	''	_	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10493
# text = When mouse MPC11 plasmacytoma cells, in which the IgH 3' enhancer is active, are fused with fibroblasts, Ig expression is extinguished at the level of transcription.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
3	MPC	MPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	11	11	NUM	CD	NumType=Card	_	_	_	_
5	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IgH	Igh	NOUN	NN	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	extinguished	extinguish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10494
# text = Here we show that in a MPC11 plasmacytoma x fibroblast environment, the IgH 3' enhancer is transcriptionally inactive.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	MPC	MPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	11	11	NUM	CD	NumType=Card	_	_	_	_
9	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
10	x	x	SYM	SYM	_	_	_	_	_
11	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
12	environment	environment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'	'	PUNCT	''	_	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
21	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10495
# text = Furthermore, we demonstrate that binding of several B cell-specific transcription factors, essential for IgH 3' enhancer activity, is lacking, which may explain 3' enhancer inactivity, although the binding of repressors cannot be excluded.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'	'	PUNCT	``	_	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	lacking	lack	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	'	'	PUNCT	``	_	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
33	inactivity	inactivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	although	although	SCONJ	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
40	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
41	not	not	PART	RB	_	_	_	_	_
42	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
43	excluded	exclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10496
# text = Moreover, the high expression level of c-myc, characteristic of the parental MPC11 cells carrying the t(12;15) translocation, is down-regulated in the hybrids to that in unfused fibroblasts.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	myc	myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
15	MPC11	Mpc11	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	12;15	12;15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	unfused	unfused	ADJ	JJ	Degree=Pos	_	_	_	_
36	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10497
# text = Therefore, inactivation of the IgH 3' enhancer is a multifactorial process affecting several transcription factors that control the cell-specific and developmental activity of the enhancer.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	PUNCT	''	_	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	multifactorial	multifactorial	ADJ	JJ	Degree=Pos	_	_	_	_
13	process	process	NOUN	NN	Number=Sing	_	_	_	_
14	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
15	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10498
# text = Document 0030012224 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012224	0030012224	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10499
# text = Sp1 is a critical factor for the monocytic specific expression of human CD14.
1	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	CD14	CD14	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10500
# text = CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages, and its expression is markedly increased during the process of monocyte differentiation.
1	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	14	14	NUM	CD	NumType=Card	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
6	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
16	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	markedly	markedly	ADV	RB	_	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	process	process	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10501
# text = In order to study CD14 gene regulation, the human CD14 gene was cloned from a partial EcoRI digested chromosome 5 library.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
5	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	14	14	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	14	14	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
20	EcoRI	Ecori	PROPN	NNP	Number=Sing	_	_	_	_
21	digested	digest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	chromosome	chromosome	DET	DT	_	_	_	_	_
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10502
# text = A 5.5-kilobase genomic clone contained the full-length CD14 coding sequence and 4.2 kilobases of 5'-upstream sequence.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	5.5	5.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
7	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	length	length	NOUN	NN	Number=Sing	_	_	_	_
12	CD14	Cd14	NOUN	NN	Number=Sing	_	_	_	_
13	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	4.2	4.2	NUM	CD	NumType=Card	_	_	_	_
17	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10503
# text = One major and one minor transcription start site were identified 101 and 130 base pairs (bp) upstream, respectively, from the protein translation start ATG.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	start	start	NOUN	NN	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	101	101	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	130	130	NUM	CD	NumType=Card	_	_	_	_
14	base	base	NOUN	NN	Number=Sing	_	_	_	_
15	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
27	start	start	NOUN	NN	Number=Sing	_	_	_	_
28	ATG	ATG	ADV	RB	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10504
# text = A DNA fragment containing 128 bp of upstream sequence had strong, monocyte-specific promoter activity in the CD14 positive monocytic cell line Mono Mac 6 as compared to the nonmonocytic cell lines HeLa and REX.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	128	128	NUM	CD	NumType=Card	_	_	_	_
6	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	monocyte-specific	monocyte-specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	14	14	NUM	CD	NumType=Card	_	_	_	_
20	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
25	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nonmonocytic	nonmonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
34	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	REX	REX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10505
# text = Four regions in this DNA fragment interact with nuclear proteins isolated from monocytic cells.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
7	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10506
# text = The Sp1 transcription factor bound to three different regions in the CD14 promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	14	14	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10507
# text = Mutation of the major Sp1 binding site (-110 bp) decreased tissue-specific promoter activity, and these results, together with transactivation experiments, demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
9	110	110	NUM	CD	NumType=Card	_	_	_	_
10	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tissue-	tissue-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	together	together	ADV	RB	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
25	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
30	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
33	role	role	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10508
# text = CD14 Sp1 site oligonucleotides bound preferentially to a 105-kDa Sp1 species, which is present in higher relative levels in monocytic than non-monocytic cells, suggesting that modification of Sp1, such as phosphorylation, may explain how the Sp1 site mediates monocytic specific promoter activity.
1	CD14	CD14	NUM	CD	NumType=Card	_	_	_	_
2	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
5	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	preferentially	preferentially	ADV	RB	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
12	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
13	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
20	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	than	than	ADP	IN	_	_	_	_	_
25	non-monocytic	non-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
40	how	how	ADV	WRB	PronType=Int	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
43	site	site	NOUN	NN	Number=Sing	_	_	_	_
44	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
46	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
47	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
48	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10509
# text = Document 0030012226 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012226	0030012226	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10510
# text = Redox signals and NF-kappaB activation in T cells.
1	Redox	Redox	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10511
# text = Accumulating data from a number of laboratories have recently indicated that the response of transcription factor NF-kappaB to alterations in the redox homeostasis of cells may play an important role in modulating immune function.
1	Accumulating	accumulate	VERB	VBG	VerbForm=Ger	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	number	number	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	laboratories	laboratory	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	recently	recently	ADV	RB	_	_	_	_	_
10	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
25	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	SCONJ	IN	_	_	_	_	_
34	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
35	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
36	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10512
# text = The activation of NF-kappaB has been recognized to regulate a number of genes necessary for normal T cell responses including IL-2, IL-6, IL-8, and several T cell surface receptors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	number	number	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
39	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10513
# text = Diminished NF-kappaB activity has been shown to occur in T cells with aging, suggesting that impaired activation of NF-kappaB might occur during cellular senescence.
1	Diminished	Diminish	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	aging	ag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
26	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	senescence	senescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10514
# text = In addition, aberrancies in NF-kappaB activity have been implicated in the immunopathogenesis of diseases involving immune or inflammatory processes such as atherosclerosis and HIV-1 infection.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	immunopathogenesis	immunopathogenesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
18	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10515
# text = The role of H2O2 and other reactive oxygen species (ROS) as an integratory secondary messenger for divergent T cell signals has been complicated by the fact that various T cell lines and peripheral blood T cells differ markedly in the levels of NF-kappaB activation induced by oxidant stress.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	O2	O2	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
9	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
10	species	species	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ROS	ROS	X	ADD	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	integratory	integratory	ADJ	JJ	Degree=Pos	_	_	_	_
17	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
18	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	complicated	complicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
37	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	markedly	markedly	ADV	RB	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
49	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
50	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
53	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10516
# text = Additionally, proposed pathways of NF-kappaB activation have been based on indirect evidence provided by experiments which used antioxidants to inhibit active NF-kappaB formation.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
15	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
16	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10517
# text = Further, complete activation of T cells requires at least two signals, one that stimulates an increase in intracellular calcium and one that stimulates enzymatic processes including kinases.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	at	at	ADV	RB	_	_	_	_	_
10	least	least	ADV	RBS	Degree=Sup	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	one	one	NUM	CD	NumType=Card	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	enzymatic	enzymatic	ADJ	JJ	Degree=Pos	_	_	_	_
27	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10518
# text = Similarly, substantial evidence indicates that full activation of NF-kappaB requires dual signals.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10519
# text = The ability of H2O2 or other ROS to induce T cell signals and functional responses by these two mechanisms is reviewed and the specific response of NF-kappaB to redox changes in T cells is examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	reviewed	review	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	redox	redox	VERB	VB	VerbForm=Inf	_	_	_	_
32	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10520
# text = Data are also presented to suggest that the redox regulation in NF-kappaB activation may be relevant to immune-related diseases and to aging.
1	Data	data	NOUN	NN	Number=Sing	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	presented	present	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	immune	immune	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	to	to	SCONJ	IN	_	_	_	_	_
26	aging	ag	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10521
# text = Document 0030012227 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012227	0030012227	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10522
# text = PGG-glucan, a soluble beta-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-kappa B-like factor in human PMN: evidence for a glycosphingolipid beta-(1,3)-glucan receptor.
1	PGG-	PGG-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	glucan	glucan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
8	1,3	1,3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	glucan	glucan	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
16	burst	burst	NOUN	NN	Number=Sing	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	microbicidal	microbicidal	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	PMN	Pmn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	:	:	PUNCT	:	_	_	_	_	_
36	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	glycosphingolipid	glycosphingolipid	ADJ	JJ	Degree=Pos	_	_	_	_
40	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,3	,3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	glucan	glucan	ADJ	JJ	Degree=Pos	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10523
# text = PGG-Glucan, a soluble beta-(1,6)-branched beta-(1,3)-linked glucose homopolymer derived from the cell wall of the yeast Saccharomyces cerevisiae, is an immunomodulator which enhances leukocyte anti-infective activity and enhances myeloid and megakaryocyte progenitor proliferation.
1	PGG-	PGG-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	Glucan	Glucan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,6	,6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	branched	branch	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,3	,3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	glucose	glucose	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	homopolymer	homopolymer	NOUN	NN	Number=Sing	_	_	_	_
22	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	yeast	yeast	PROPN	NNP	Number=Sing	_	_	_	_
30	Saccharomyces	Saccharomyces	PROPN	NNP	Number=Sing	_	_	_	_
31	cerevisiae	cerevisia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	immunomodulator	immunomodulator	NOUN	NN	Number=Sing	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
39	anti-infective	anti-infective	ADJ	JJ	Degree=Pos	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
43	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	megakaryocyte	megakaryocyte	ADJ	JJ	Degree=Pos	_	_	_	_
46	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
47	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10524
# text = Incubation of human whole blood with PGG-Glucan significantly enhanced the oxidative burst response of subsequently isolated blood leukocytes to both soluble and particulate activators in a dose-dependent manner, and increased leukocyte microbicidal activity.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	PGG	PGG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Glucan	Glucan	PROPN	NNP	Number=Sing	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
14	burst	burst	NOUN	NN	Number=Sing	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	subsequently	subsequently	ADV	RB	_	_	_	_	_
18	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	particulate	particulate	ADJ	JJ	Degree=Pos	_	_	_	_
26	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
37	microbicidal	microbicidal	ADJ	JJ	Degree=Pos	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10525
# text = No evidence for inflammatory cytokine production was obtained under these conditions.
1	No	no	DET	DT	_	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	under	under	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10526
# text = Electrophoretic mobility shift assays demonstrated that PGG-Glucan induced the activation of an NF-kappaB-like nuclear transcription factor in purified human neutrophils.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	PGG	PGG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Glucan	Glucan	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10527
# text = The binding of 3H-PGG-Glucan to human leukocyte membranes was specific, concentration-dependent, saturable, and high affinity
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	3H	3H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	PGG	PGG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Glucan	Glucan	PROPN	NNP	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	human	human	VERB	VB	VerbForm=Inf	_	_	_	_
11	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
12	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	saturable	saturable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
24	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10528
# text = (Kd approximately 6 nM).
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Kd	K	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	approximately	approximately	ADV	RB	_	_	_	_	_
4	6	6	NUM	CD	NumType=Card	_	_	_	_
5	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10529
# text = A monoclonal antibody specific to the glycosphingolipid lactosylceramide was able to inhibit activation of the NF-kappaB-like factor by PGG-Glucan, and ligand binding data, including polysaccharide specificity, suggested that the PGG-Glucan binding moiety was lactosylceramide.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
3	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	glycosphingolipid	glycosphingolipid	ADJ	JJ	Degree=Pos	_	_	_	_
8	lactosylceramide	lactosylceramide	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	PGG	PGG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	Glucan	Glucan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	data	data	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
33	polysaccharide	polysaccharide	NOUN	NN	Number=Sing	_	_	_	_
34	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	PGG	PGG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Glucan	Glucan	PROPN	NNP	Number=Sing	_	_	_	_
42	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
43	moiety	moiety	NOUN	NN	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	lactosylceramide	lactosylceramide	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10530
# text = These results indicate that PGG-Glucan enhances neutrophil anti-microbial functions and that interaction between this beta-glucan and human neutrophils is mediated by the glycosphingolipid lactosylceramide present at the cell surface.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PGG	PGG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Glucan	Glucan	PROPN	NNP	Number=Sing	_	_	_	_
8	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
9	neutrophil	neutrophil	ADP	IN	_	_	_	_	_
10	anti-microbial	anti-microbial	ADJ	JJ	Degree=Pos	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	glucan	glucan	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	glycosphingolipid	glycosphingolipid	ADJ	JJ	Degree=Pos	_	_	_	_
28	lactosylceramide	lactosylceramide	NOUN	NN	Number=Sing	_	_	_	_
29	present	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10531
# text = Document 0030012228 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012228	0030012228	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10532
# text = Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.
1	Cloning	Cloning	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	myeloid-cell	myeloid-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	C	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10533
# text = Chicken NF-M transcription factor, in cooperation with either c-Myb or v-Myb, is active in the combinatorial activation of myeloid-cell-specific genes in heterologous cell types, such as embryonic fibroblasts.
1	Chicken	Chicken	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	M	M	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	combinatorial	combinatorial	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	myeloid-cell	myeloid-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
38	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10534
# text = In humans, similar effects were observed with homologous members of the CCAAT/enhancer-binding protein (C/EBP) family of transcriptional regulators, especially the human homolog of chicken NF-M, C/EBP-beta (NF-IL6).
1	In	in	ADP	IN	_	_	_	_	_
2	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	C/	Cith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	especially	especially	ADV	RB	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	chicken	chicken	NOUN	NN	Number=Sing	_	_	_	_
34	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	C/EBP-	C/EBP-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10535
# text = However, the NF-IL6 gene is expressed in a variety of nonmyeloid cell types and is strongly inducible in response to inflammatory stimuli, making it an unlikely candidate to have an exclusive role as a combinatorial differentiation switch during myelopoiesis in human cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nonmyeloid	nonmyeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	types	type	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	strongly	strongly	ADV	RB	_	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	making	make	VERB	VBG	VerbForm=Ger	_	_	_	_
28	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	unlikely	unlikely	ADJ	JJ	Degree=Pos	_	_	_	_
31	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	exclusive	exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	combinatorial	combinatorial	ADJ	JJ	Degree=Pos	_	_	_	_
40	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
41	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
42	during	during	ADP	IN	_	_	_	_	_
43	myelopoiesis	myelopoiesis	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10536
# text = By using a reverse transcription-PCR-based approach and a set of primers specific for the DNA-binding domains of highly homologous members of the C/EBP family of transcriptional regulators, we have cloned a novel human gene encoding a member of the C/EBP gene family, identified as the human homolog of CRP1, C/EBP-epsilon.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	set	set	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	primers	primer	NOUN	NNS	Number=Plur	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	highly	highly	ADV	RB	_	_	_	_	_
25	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
38	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	member	member	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
51	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
52	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
53	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	as	as	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
59	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	CRP1	CRP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10537
# text = A 1.2-kb cDNA encoding full-length human C/EBP-epsilon was cloned from a promyelocyte-late myeloblast-derived lambda gt11 library.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	1.2	1.2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
5	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	length	length	NOUN	NN	Number=Sing	_	_	_	_
10	human	human	NOUN	NN	Number=Sing	_	_	_	_
11	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	EBP-	EBP-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
22	myeloblast	myeloblast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	lambda	lambda	NOUN	NN	Number=Sing	_	_	_	_
26	gt11	gt11	NUM	CD	NumType=Card	_	_	_	_
27	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10538
# text = Molecular analysis of the cDNA and genomic clones indicated the presence of two exons encoding a protein with an apparent molecular mass of 32 kDa and a pI of 9.5.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cDNA	cDNa	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
8	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
9	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
15	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	32	32	NUM	CD	NumType=Card	_	_	_	_
25	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	pI	pi	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	9.5	9.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10539
# text = Primer extension analysis of C/EBP-epsilon mRNA detected a single major transcription start site approximately 200 bp upstream of the start codon.
1	Primer	Primer	NOUN	NN	Number=Sing	_	_	_	_
2	extension	extension	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	start	start	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	approximately	approximately	ADV	RB	_	_	_	_	_
19	200	200	NUM	CD	NumType=Card	_	_	_	_
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	start	start	NOUN	NN	Number=Sing	_	_	_	_
25	codon	codon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10540
# text = The putative promoter area is similar to those of several other myeloid-cell-specific genes in that it contains no TATAAA box but has a number of purine-rich stretches with multiple sites for the factors of the Ets family of transcriptional regulators.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	area	area	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	no	no	DET	DT	_	_	_	_	_
23	TATAAA	TATAAa	NOUN	NN	Number=Sing	_	_	_	_
24	box	box	NOUN	NN	Number=Sing	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	number	number	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
33	stretches	stretch	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
43	family	family	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
46	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10541
# text = Northern blot analyses indicated a highly restricted mRNA expression pattern, with the strongest expression occurring in promyelocyte and late-myeloblast-like cell lines.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	strongest	strongest	ADJ	JJS	Degree=Sup	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	late	late	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	myeloblast	myeloblast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10542
# text = Western blot and immunoprecipitation studies using rabbit anti-C/EBP-epsilon antibodies raised against the N-terminal portion of C/EBP-epsilon (amino acids 1 to 115) showed that C/EBP-epsilon is a 32-kDa nuclear phosphoprotein.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
8	anti-C	anti-c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
13	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
14	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	against	against	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
19	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	amino	amino	DET	DT	_	_	_	_	_
28	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	115	115	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	EBP-	EBP-	PUNCT	:	_	_	_	_	SpaceAfter=No
38	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
44	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
45	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10543
# text = The human C/EBP-epsilon protein exhibited strong and specific binding to double-stranded DNA containing consensus C/EBP sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	C	C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stranded	stranded	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
20	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
21	C/	C/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10544
# text = Cotransfection of the C/EBP-epsilon sense and antisense expression constructs together with chloramphenicol acetyltransferase reporter vectors containing myeloid-cell-specific c-mim and human myeloperoxidase promoters suggested a role for C/EBP-epsilon transcription factor in the regulation of a subset of myeloid-cell-specific genes.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
9	sense	sense	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
14	together	together	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
17	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	myeloid-cell	myeloid-cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	c-mim	c-mim	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	myeloperoxidase	myeloperoxidase	NOUN	NN	Number=Sing	_	_	_	_
28	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
29	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
52	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10545
# text = Transient tranfection of a promyelocyte cell line (NB4) with a C/EBP-epsilon expression plasmid increased cell growth by sevenfold, while antisense C/EBP-epsilon caused a fivefold decrease in clonal growth of these cells.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	tranfection	tranfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NB4	NB4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	epsilon	epsilon	X	FW	Foreign=Yes	_	_	_	_
18	expression	expression	X	GW	_	_	_	_	_
19	plasmid	plasmid	X	AFX	_	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	sevenfold	sevenfold	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	while	while	SCONJ	IN	_	_	_	_	_
27	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
28	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	EBP-	EBP-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
32	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	fivefold	fivefold	ADJ	JJ	Degree=Pos	_	_	_	_
35	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
38	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10546
# text = Document 0030012232 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012232	0030012232	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10547
# text = Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Ets-	Ets-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10548
# text = The retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates cell cycle progression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
16	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10549
# text = Elf-1 is a lymphoid-specific Ets transcription factor that regulates inducible gene expression during T cell activation.
1	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10550
# text = In this report, it is demonstrated that Elf-1 contains a sequence motif that is highly related to the Rb binding sites of several viral oncoproteins and binds to the pocket region of Rb both in vitro and in vivo.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	highly	highly	ADV	RB	_	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Rb	Rb	NOUN	NN	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	pocket	pocket	NOUN	NN	Number=Sing	_	_	_	_
34	region	region	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
37	both	both	CCONJ	CC	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10551
# text = Elf-1 binds exclusively to the underphosphorylated form of Rb and fails to bind to Rb mutants derived from patients with retinoblastoma.
1	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
5	exclusively	exclusively	ADV	RB	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	underphosphorylated	underphosphorylated	ADJ	JJ	Degree=Pos	_	_	_	_
9	form	form	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
18	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10552
# text = Co-immunoprecipitation experiments demonstrated an association between Elf-1 and Rb in resting normal human T cells.
1	Co	co	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-immunoprecipitation	-immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	association	association	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10553
# text = After T cell activation, the phosphorylation of Rb results in the release of Elf-1, which is correlated temporally with the activation of Elf-1-mediated transcription.
1	After	after	SCONJ	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	release	release	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	temporally	temporally	ADV	RB	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10554
# text = Overexpression of a phosphorylation-defective form of Rb inhibited Elf-1-dependent transcription during T cell activation.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10555
# text = These results demonstrate that Rb interacts specifically with a lineage-restricted Ets transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10556
# text = This regulated interaction may be important for the coordination of lineage-specific effector functions such as lymphokine production with cell cycle progression in activated T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	regulated	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
3	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	lymphokine	lymphokine	ADJ	JJ	Degree=Pos	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
23	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10557
# text = Document 0030012238 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012238	0030012238	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10558
# text = Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	8	8	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	through	through	SCONJ	IN	_	_	_	_	_
20	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
21	concurrently	concurrently	ADV	RB	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	kappaB-	kappaB-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	8	8	NUM	CD	NumType=Card	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10559
# text = Cytomegalovirus (CMV) infection induced interleukin-8 (IL-8) gene transcription in a human monocytic cell line, THP-1 cells, leading to IL-8 secretion.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	8	8	NUM	CD	NumType=Card	_	_	_	_
34	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10560
# text = The functional analysis of the IL-8 gene revealed that both AP-1- and NF-kappaB factor-binding elements were involved in conferring the responsiveness to CMV.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	8	8	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	SCONJ	IN	_	_	_	_	_
28	conferring	conferr	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10561
# text = Moreover, electrophoretic mobility shift assays demonstrated that CMV induced the formation of NF-kappaB and AP-1 complexes.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
7	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10562
# text = These results suggest that CMV activates these transcriptional factors, resulting in IL-8 gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10563
# text = Document 0030012240 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012240	0030012240	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10564
# text = The NF kappa B independent cis-acting sequences in HIV-1 LTR responsive to T-cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
3	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
4	B	B	PROPN	NNP	Number=Sing	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
15	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	T-	t-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10565
# text = The rate of transcription initiation directed by the long terminal repeat (LTR) of HIV-1 increases in response to mitogenic stimuli of T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
24	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10566
# text = Here we show that the response of the HIV-1 LTR may be governed by two independent sequences located 5' to the site of transcription initiation sequences that bind either NFAT-1 or NF kappa B.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	governed	govern	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	'	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
29	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	either	either	CCONJ	CC	_	_	_	_	_
33	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10567
# text = The rate of LTR-directed gene expression increased in response to treatment with either a phorbol ester or tumor necrosis factor alpha if either the NFAT-1 or NF kappa B binding sites were deleted, but failed to respond to these mitogenic stimuli if both sequences were absent.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	treatment	treatment	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	either	either	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	if	if	SCONJ	IN	_	_	_	_	_
25	either	either	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	failed	fail	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
45	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
46	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
47	if	if	SCONJ	IN	_	_	_	_	_
48	both	both	DET	DT	_	_	_	_	_
49	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
50	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10568
# text = The HIV-1 mutant virus containing both NF kappa B and NFAT-1 deletion was able to replicate although at a much decreased growth rate, while the deletion of NFAT-1 alone increased the viral growth rate in Jurkat cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
21	although	although	SCONJ	IN	_	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
25	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	alone	alone	ADV	RB	_	_	_	_	_
37	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
41	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10569
# text = Neither deletion of NF kappa B nor deletion of NFAT-1 decreased activation of viral replication by phorbol ester.
1	Neither	neither	DET	DT	_	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	nor	nor	ADJ	JJ	Degree=Pos	_	_	_	_
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10570
# text = Document 0030012241 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012241	0030012241	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10571
# text = Control of NF-kappa B activity by the I kappa B beta inhibitor.
1	Control	Control	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10572
# text = The transcription factor NF-kappa B is maintained in an inactive cytoplasmic state by I kappa B inhibitors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	maintained	maintain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	state	state	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10573
# text = In mammalian cells, I kappa B alpha and I kappa B beta proteins have been purified and shown to be the inhibitors of NF-kappa B through their association with the p65 or c-Rel subunits.
1	In	in	ADP	IN	_	_	_	_	_
2	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	through	through	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	association	association	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
39	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10574
# text = In addition, we have isolated a third NF-kappa B inhibitor, I kappa B epsilon (1).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10575
# text = Upon treatment with a large variety of inducers, I kappa B alpha, I kappa B beta are proteolytically degraded, resulting in NF-kappa B translocation into the nucleus.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
6	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	proteolytically	proteolytically	ADV	RB	_	_	_	_	_
21	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
30	into	into	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10576
# text = Here we show that in E29.1
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	E29.1	E29.1	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 10577
# text = T cell hybridoma
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	hybridoma	hybridoma	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10578
# text = I kappa B alpha and I kappa B beta are equally associated with p65 and that I kappa B beta is degraded in response to TNF alpha in contrast to what has been originally published.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	b	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	equally	equally	ADV	RB	_	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	SCONJ	IN	_	_	_	_	_
31	what	what	PRON	WP	PronType=Int	_	_	_	_
32	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	originally	originally	ADV	RB	_	_	_	_	_
35	published	publish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10579
# text = Our data also suggest that, unlike I kappa B alpha, I kappa B beta is constitutively phosphorylated and resynthesized as a hypophosphorylated form.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	unlike	unlike	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	constitutively	constitutively	ADV	RB	_	_	_	_	_
19	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	resynthesized	resynthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	hypophosphorylated	hypophosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10580
# text = The absence of slow migrating forms of I kappa B beta following stimulation suggests that the phosphorylation does not necessarily constitute the signal-induced event which targets the molecule for proteolysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
5	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
6	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	necessarily	necessarily	ADV	RB	_	_	_	_	_
21	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	event	event	NOUN	NN	Number=Sing	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	targets	target	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10581
# text = Document 0030012248 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012248	0030012248	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10582
# text = Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site.
1	Lipopolysaccharide	Lipopolysaccharide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	p65	p65	NUM	CD	NumType=Card	_	_	_	_
21	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10583
# text = Exposure of monocytic cells to bacterial lipopolysaccharide (LPS) activates the NF-kappa
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	LPS	LPS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10584
# text = B/Rel family of proteins and leads to the rapid induction of inflammatory gene products, including tissue factor (TF).
1	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	ADJ	JJ	Degree=Pos	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
19	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10585
# text = TF is the primary cellular initiator of the coagulation protease cascades.
1	TF	TF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	initiator	initiator	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
10	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
11	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10586
# text = Here we report the characterization of a nuclear complex from human monocytic cells that bound to a kappa B-like site, 5'-CGGAGTTTCC-3', in the 5'-flanking region of the human TF gene.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
26	-CGGAGTTTCC	-cggagtttcc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10587
# text = This nuclear complex was activated by LPS with kinetics that preceded induction of the TF gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	preceded	proceed	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10588
# text = In vitro binding studies demonstrated that the TF site bound translated c-Rel and p65 homodimers but not p50/p65 heterodimers or p50 homodimers.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
11	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p65	p65	NUM	CD	NumType=Card	_	_	_	_
16	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
21	p65	p65	NUM	CD	NumType=Card	_	_	_	_
22	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
25	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10589
# text = Base-pair substitutions in the TF site indicated that the presence of a cytosine at position 1 precluded binding of NF-kappa B.
1	Base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
4	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	cytosine	cytosine	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	position	position	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	precluded	preclude	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10590
# text = In fact, under low-ionic-strength conditions, the TF complex did not migrate with translated p50/p65 dimers but instead comigrated with c-Rel/p65 dimers.
1	In	in	ADP	IN	_	_	_	_	_
2	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	under	under	ADP	IN	_	_	_	_	_
5	low-ionic	low-ionic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	strength	strength	NOUN	NN	Number=Sing	_	_	_	_
8	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	migrate	migrate	VERB	VB	VerbForm=Inf	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	p65	p65	NUM	CD	NumType=Card	_	_	_	_
21	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	instead	instead	ADV	RB	_	_	_	_	_
24	comigrated	comigrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	p65	p65	NUM	CD	NumType=Card	_	_	_	_
30	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10591
# text = Antibodies against the NF-kappa B and Rel proteins and UV cross-linking studies revealed the presence of c-Rel and p65 and the absence of p50 in the TF complex and further showed that c-Rel/p65 heterodimers selectively bound to the TF kappa B-like site.
1	Antibodies	Antibody	NOUN	NNS	Number=Plur	_	_	_	_
2	against	against	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
10	proteins	protein	PROPN	NNPS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
13	cross	cross	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
14	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
15	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
16	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	p50	p50	NUM	CD	NumType=Card	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
33	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	further	further	ADV	RB	_	_	_	_	_
36	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
39	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	p65	p65	NUM	CD	NumType=Card	_	_	_	_
42	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
43	selectively	selectively	ADV	RB	_	_	_	_	_
44	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
48	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
49	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
52	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10592
# text = Functional studies indicated that the TF site conferred LPS inducibility on a heterologous promoter and was transactivated by c-Rel or p65.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
10	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10593
# text = Taken together, our results demonstrated that binding of c-Rel/p65 heterodimers to a novel kappa
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	p65	p65	NUM	CD	NumType=Card	_	_	_	_
15	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10594
# text = B-like site mediated LPS induction of TF gene expression in monocytic cells.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
10	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10595
# text = Document 0030012250 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012250	0030012250	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10596
# text = A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	thiol	thiol	ADJ	JJ	Degree=Pos	_	_	_	_
3	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
4	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
6	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
7	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10597
# text = The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	germline	germline	PROPN	NNP	Number=Sing	_	_	_	_
22	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	there	there	PRON	EX	_	_	_	_	_
27	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
29	information	information	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	SCONJ	IN	_	_	_	_	_
31	whether	whether	SCONJ	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
36	in	in	SCONJ	IN	_	_	_	_	_
37	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
38	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
39	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10598
# text = Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75.
1	Accordingly	accordingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	germline	germline	PROPN	NNP	Number=Sing	_	_	_	_
13	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	's	's	PART	POS	_	_	_	_	_
21	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	DND39	DND39	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	DG75	DG75	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10599
# text = In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	n-	n-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-L-	-l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
16	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	_
17	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	_
37	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
38	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10600
# text = Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
7	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	decoy	decoy	NOUN	NN	Number=Sing	_	_	_	_
30	oligodeoxynucleotides	oligodeoxynucleotide	NOUN	NNS	Number=Plur	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
37	only	only	ADV	RB	_	_	_	_	_
38	partly	partly	ADV	RB	_	_	_	_	_
39	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
46	Cepsilon	Cepsilon	NOUN	NN	Number=Sing	_	_	_	_
47	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10601
# text = However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	decoy	decoy	NOUN	NN	Number=Sing	_	_	_	_
6	oligodeoxynucleotides	oligodeoxynucleotide	NOUN	NNS	Number=Plur	_	_	_	_
7	together	together	ADV	RB	_	_	_	_	_
8	almost	almost	ADV	RB	_	_	_	_	_
9	completely	completely	ADV	RB	_	_	_	_	_
10	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
17	Cepsilon	Cepsilon	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10602
# text = Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB.
1	Of	of	ADP	IN	_	_	_	_	_
2	note	note	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
15	Cepsilon	Cepsilon	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	markedly	markedly	ADV	RB	_	_	_	_	_
19	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	decoy	decoy	NOUN	NN	Number=Sing	_	_	_	_
26	oligodeoxynucleotide	oligodeoxynucleotide	ADV	RB	_	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10603
# text = The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	deletional	deletional	ADJ	JJ	Degree=Pos	_	_	_	_
10	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
11	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
12	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
15	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10604
# text = NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Smu/	Smuith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	Sepsilon	Sepsilon	PROPN	NNP	Number=Sing	_	_	_	_
8	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
9	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	_
22	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
23	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10605
# text = It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
8	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10606
# text = These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	germline	germline	PROPN	NNP	Number=Sing	_	_	_	_
19	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-mediated	-mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
37	in	in	SCONJ	IN	_	_	_	_	_
38	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
39	both	both	DET	DT	_	_	_	_	_
40	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	germline	germline	PROPN	NNP	Number=Sing	_	_	_	_
43	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	class	class	NOUN	NN	Number=Sing	_	_	_	_
47	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10607
# text = Document 0030012253 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012253	0030012253	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10608
# text = Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	_
8	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	allergen	allergen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10609
# text = Glucocorticoids (GC) have long been used as the most effective agents for the treatment of allergic diseases accompanied by eosinophilia such as chronic asthma and atopic dermatitis.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	long	long	ADV	RB	Degree=Pos	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	most	most	ADV	RBS	_	_	_	_	_
12	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
13	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
19	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
20	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	eosinophilia	eosinophilion	NOUN	NN	Number=Sing	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
26	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
29	dermatitis	dermatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10610
# text = The development of chronic eosinophilic inflammation is dependent on interleukin-5 (IL-5), a selective eosinophil-activating factor, produced by helper T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
5	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
6	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	5	5	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
21	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10611
# text = To delineate the regulatory mechanisms of human IL-5 synthesis, we established allergen-specific CD4+ T-cell clones from asthmatic patients.
1	To	to	PART	TO	_	_	_	_	_
2	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	5	5	NUM	CD	NumType=Card	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	established	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	allergen-specific	allergen-specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	T-	T-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	asthmatic	asthmatic	ADJ	JJ	Degree=Pos	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10612
# text = GC efficiently suppressed IL-5 synthesis of T-cell clones activated via either T-cell receptor (TCR) or IL-2 receptor (IL-2R).
1	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
2	efficiently	efficiently	ADV	RB	_	_	_	_	_
3	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	either	either	DET	DT	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2R	2r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10613
# text = Induction of IL-5 mRNA upon TCR and IL-2R stimulation was totally inhibited by dexamethasone.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
7	upon	upon	ADP	IN	_	_	_	_	_
8	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	X	LS	_	_	_	_	SpaceAfter=No
13	R	r	X	GW	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	totally	totally	ADV	RB	_	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10614
# text = Human IL-5 promoter/enhancer-luciferase gene construct transfected to T-cell clones was transcribed on either TCR or IL-2R stimulation and was clearly downregulated by dexamethasone, indicating that the approximately 500-bp human IL-5 gene segment located 5' upstream of the coding region contains activation-inducible enhancer elements responsible for the regulation by GC.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	5	5	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-luciferase	-luciferase	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	either	either	DET	DT	_	_	_	_	_
20	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	clearly	clearly	ADV	RB	_	_	_	_	_
29	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	approximately	approximately	ADV	RB	_	_	_	_	_
37	500	500	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	5	5	NUM	CD	NumType=Card	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
45	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
46	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	'	'	PUNCT	''	_	_	_	_	_
49	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
53	region	region	NOUN	NN	Number=Sing	_	_	_	_
54	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
55	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
58	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
59	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
60	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
61	for	for	ADP	IN	_	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
64	by	by	ADP	IN	_	_	_	_	_
65	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10615
# text = Electrophoretic mobility shift assay analysis suggested that AP-1 and NF-kappaB are among the possible targets of GC actions on TCR-stimulated T cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	analysis	analysis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	among	among	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
19	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	_
22	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10616
# text = NF-AT and NF-kappaB were not significantly induced by IL-2 stimulation.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10617
# text = Our results showing that GC suppressed IL-5 production by human CD4+ T cells activated by two distinct stimuli, TCR and IL-2R stimulation, underscore the efficacy of GC in the treatment of allergic diseases via suppression of T-cell IL-5 synthesis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
6	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	5	5	NUM	CD	NumType=Card	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	+	+	SYM	SYM	_	_	_	_	_
15	T	t	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
21	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	underscore	underscore	ADV	RB	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
40	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
41	via	via	ADP	IN	_	_	_	_	_
42	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	5	5	NUM	CD	NumType=Card	_	_	_	_
49	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10618
# text = Document 0030012258 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012258	0030012258	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10619
# text = Transcription of a minimal promoter from the NF-IL6 gene is regulated by CREB/ATF and SP1 proteins in U937 promonocytic cells.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	U937	U937	NUM	CD	NumType=Card	_	_	_	_
23	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10620
# text = NF-IL6 is an important transcriptional regulator of genes induced in activated monocytes/macrophages, and NF-IL6 is the only CCAAT/enhancer-binding protein (C/EBP) family member whose steady-state mRNA levels increase upon activation of monocytes (1).
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
25	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	enhancer-binding	enhancer-binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	C/	Cith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	_
34	member	member	NOUN	NN	Number=Sing	_	_	_	_
35	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
36	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	state	state	NOUN	NN	Number=Sing	_	_	_	_
39	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
40	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
41	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
42	upon	upon	ADP	IN	_	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10621
# text = We show that increased transcription of the NF-IL6 gene is responsible, at least in part, for induction of NF-IL6 mRNA following activation of U937 promonocytic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	at	at	ADV	RB	_	_	_	_	_
16	least	least	ADV	RBS	Degree=Sup	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
26	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	U937	U937	NUM	CD	NumType=Card	_	_	_	_
31	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10622
# text = We have identified a 104-bp minimal promoter region of the NF-IL6 gene that is sufficient for basal and activation-dependent induction of transcription in U937 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	104	104	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	U937	U937	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10623
# text = This region contains binding sites for the cAMP response element-binding protein/activation transcription factor (CREB/ATF) and Sp1 families of transcription factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
25	families	family	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10624
# text = Each site is functionally important and contributes independently to transcription of the NF-IL6 gene in U937 cells.
1	Each	each	DET	DT	_	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	functionally	functionally	ADV	RB	_	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	independently	independently	ADV	RB	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	U937	U937	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10625
# text = Document 0030012260 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012260	0030012260	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10626
# text = Identification of nucleotide sequences that regulate transcription of the MCF13 murine leukemia virus long terminal repeat in activated T cells.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	MCF	Mcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	13	13	NUM	CD	NumType=Card	_	_	_	_
12	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	long	long	ADV	RB	Degree=Pos	_	_	_	_
16	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
17	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10627
# text = The region downstream of the enhancer (DEN) of the long terminal repeat of the mink cell focus-forming murine leukemia virus is important for viral pathogenicity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	DEN	DEN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
13	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
14	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	mink	mink	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	focus	focus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
22	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
29	pathogenicity	pathogenicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10628
# text = Another important activity of DEN is its control of transcription in activated T cells, and we have determined that an NF-kappaB site is critical for this activity.
1	Another	another	DET	DT	_	_	_	_	_
2	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	DEN	DEN	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10629
# text = Document 0030012261 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012261	0030012261	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10630
# text = Lymphoid specific gene expression of the adenovirus early region 3 promoter is mediated by NF-kappa B binding motifs.
1	Lymphoid	Lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	adenovirus	adenovirus	ADJ	JJ	Degree=Pos	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10631
# text = A primary site of infection by human adenoviruses is lymphoid cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	adenoviruses	adenoviruse	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10632
# text = However, analysis of the viral control elements and the cellular factors that regulate adenoviral gene expression in lymphocytes has not been reported.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	adenoviral	adenoviral	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10633
# text = The adenovirus early region 3 (ES) gene products are involved in the maintenance of viral persistence by complexing with the class I MHC antigens, thus preventing their cell surface expression with a resultant decrease in host immunologic destruction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adenovirus	adenovirus	ADJ	JJ	Degree=Pos	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ES	ES	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	products	product	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
18	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	complexing	complex	VERB	VBG	VerbForm=Ger	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
26	antigens	antigens	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	thus	thus	ADV	RB	_	_	_	_	_
29	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	resultant	resultant	ADJ	JJ	Degree=Pos	_	_	_	_
37	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	host	host	NOUN	NN	Number=Sing	_	_	_	_
40	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
41	destruction	destruction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10634
# text = To determine whether different cellular factors were involved in E3 regulation in lymphocytes as compared with HeLa cells, both DNA binding and transfection analysis with the E3 promoter in both cell types were performed.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	E3	E3	NUM	CD	NumType=Card	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
25	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	types	type	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10635
# text = These studies detected two novel domains referred to as L1 and L2 with a variety of lymphoid but not HeLa extracts.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
7	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	L1	L1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	L2	L2	NUM	CD	NumType=Card	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
21	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10636
# text = Each of these domains possessed strong homology to motifs previously found to bind the cellular factor NF-kappa B.
1	Each	each	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
5	possessed	possess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
7	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
10	previously	previously	ADV	RB	_	_	_	_	_
11	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10637
# text = Transfections of E3 constructs linked to the chloramphenicol acetyltransferase gene revealed that mutagenesis of the distal NF-kappa B motif (L2) had minimal effects on promoter expression in HeLa cells, but resulted in dramatic decreases in expression by lymphoid cells.
1	Transfections	Transfection	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	E3	E3	NUM	CD	NumType=Card	_	_	_	_
4	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
5	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
9	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	L2	l2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
39	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10638
# text = In contrast, mutagenesis of proximal NF-kappa B motif (L1) had minimal effects on gene expression in both HeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the L2 mutation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	L1	L1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	small	small	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	reproducible	reproducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	when	when	ADV	WRB	PronType=Int	_	_	_	_
45	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	L2	l2	NOUN	NN	Number=Sing	_	_	_	_
49	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10639
# text = Reversing the position and subsequent mutagenesis of the L1 and L2 domains indicated that the primary sequence of these motifs rather than their position in the E3 promoter was critical for regulating gene expression.
1	Reversing	Reverse	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	position	position	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	L1	L1	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	L2	L2	NUM	CD	NumType=Card	_	_	_	_
12	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
13	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
21	rather	rather	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	position	position	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	SCONJ	IN	_	_	_	_	_
32	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10640
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10641
# text = Document 0030012262 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012262	0030012262	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10642
# text = The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Megakaryocyte	Megakaryocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
4	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
12	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
17	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
27	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10643
# text = The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
4	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	collagen	collagen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10644
# text = Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	_
6	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
11	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	core	core	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
19	-30	-30	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	92	92	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	351	351	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
40	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	'	'	PUNCT	''	_	_	_	_	_
42	flank	flank	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10645
# text = We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	229	229	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	''	_	_	_	_	_
15	flank	flank	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	_
19	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	level	level	NOUN	NN	Number=Sing	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	features	feature	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10646
# text = Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
3	AP1	AP1	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	dyad	dyad	NOUN	NN	Number=Sing	_	_	_	_
8	symmetry	symmetry	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	enhancer	enhancer	ADJ	JJR	Degree=Cmp	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
20	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	members	member	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	fos/c	fos/c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-jun	-jun	ADJ	JJ	Degree=Pos	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10647
# text = The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	AP1	AP1	NUM	CD	NumType=Card	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mitogen	mitogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	_
24	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10648
# text = Inhibition of the MAP kinase cascade with PD98059, a specific inhibitor of MAPK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megakaryocytic.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	alpha2	alpha2	NUM	CD	NumType=Card	_	_	_	_
24	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	_
25	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	become	become	VERB	VB	VerbForm=Inf	_	_	_	_
31	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10649
# text = We provide a model of megakaryocytic differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kinase pathway to activate two tandem AP1 binding sites in the alpha2 integrin enhancer.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	alpha2	alpha2	NOUN	NN	Number=Sing	_	_	_	_
14	integrin	integrin	ADP	IN	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
17	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
25	two	two	NUM	CD	NumType=Card	_	_	_	_
26	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
27	AP1	AP1	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	alpha2	alpha2	NOUN	NN	Number=Sing	_	_	_	_
33	integrin	integrin	ADP	IN	_	_	_	_	_
34	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10650
# text = Document 0030012269 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012269	0030012269	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10651
# text = Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	granulopoiesis	granulopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
13	lethality	lethality	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	B	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
21	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10652
# text = Transcription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins, mainly I kappa B alpha and I kappa B beta.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	X	GW	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	mainly	mainly	ADV	RB	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10653
# text = Apparently normal at birth, I kappa B alpha-/- mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days.
1	Apparently	apparently	ADV	RB	_	_	_	_	_
2	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	birth	birth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-/-	-/-	PUNCT	.	_	_	_	_	_
11	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
12	exhibit	exhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
14	runting	runting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
17	defects	defects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
21	granulopoiesis	granulopoiesis	NOUN	NN	Number=Sing	_	_	_	_
22	postnatally	postnatally	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	typically	typically	ADV	RB	_	_	_	_	_
25	dying	die	VERB	VBG	VerbForm=Ger	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	8	8	NUM	CD	NumType=Card	_	_	_	_
28	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10654
# text = Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B. NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities.
1	Hematopoietic	Hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
2	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
6	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	ADV	RB	_	_	_	_	_
23	all	all	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	thought	think	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_
36	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
41	results	result	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
44	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
45	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
46	because	because	SCONJ	IN	_	_	_	_	_
47	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
48	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
49	both	both	CCONJ	CC	_	_	_	_	_
50	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
51	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
52	B	b	PROPN	NNP	Number=Sing	_	_	_	_
53	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
57	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
62	B	B	PROPN	NNP	Number=Sing	_	_	_	_
63	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
64	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
65	dramatically	dramatically	ADV	RB	_	_	_	_	_
66	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	_
67	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
68	of	of	ADP	IN	_	_	_	_	_
69	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10655
# text = In contrast to hematopoietic cells, I kappa B alpha-/- embryonic fibroblasts show minimal constitutive NF-kappa B, as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-/-	-/-	PUNCT	.	_	_	_	_	_
12	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
13	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
14	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
37	with	with	SCONJ	IN	_	_	_	_	_
38	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
39	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
40	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
41	beta	beof	NOUN	NN	Number=Sing	_	_	_	_
42	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10656
# text = Our results indicate that I kappa b beta, but not I kappa B alpha, is required for the signal-dependent activation of NF-kappa B in fibroblasts.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	b	benefit	NOUN	NN	Number=Sing	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10657
# text = However, I kappa B alpha is required for the postinduction repression of NF-kappa B in fibroblasts.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	postinduction	postinduction	NOUN	NN	Number=Sing	_	_	_	_
12	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10658
# text = These results define distinct roles for the two forms of I kappa B and demonstrate the necessity for stringent control of NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	B	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	necessity	necessity	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	stringent	stringent	ADJ	JJ	Degree=Pos	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10659
# text = Document 0030012274 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012274	0030012274	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10660
# text = The evolutionarily conserved sequence upstream of the human Ig heavy chain S gamma 3 region is an inducible promoter: synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	evolutionarily	evolutionarily	ADV	RB	Degree=Pos	_	_	_	_
3	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
10	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
11	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
12	S	's	PART	POS	_	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
25	ligand	ligand	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	via	via	ADP	IN	_	_	_	_	_
31	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	6	6	NUM	CD	NumType=Card	_	_	_	_
40	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
41	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10661
# text = Germline C gamma gene transcription is a crucial event in the process that leads to switch DNA recombination to IgG, but its regulation in the human is poorly understood.
1	Germline	Germline	PROPN	NNP	Number=Sing	_	_	_	_
2	C	C	PROPN	NNP	Number=Sing	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	event	event	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	process	process	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	switch	switch	VERB	VB	VerbForm=Inf	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	human	human	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	poorly	poorly	ADV	RB	_	_	_	_	_
30	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10662
# text = We took advantage of our monoclonal model of germinal center B cell differentiation, IgM+ IgD+ CL-01 cells, to define the role of the I gamma 3 evolutionarily conserved sequence (ECS) in the germline transcriptional activation of the human C gamma 3 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	took	take	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
7	model	model	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
10	center	center	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IgM	IgM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	IgD	IgD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	+	+	SYM	SYM	_	_	_	_	_
19	CL	CL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	01	01	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	I	I	PROPN	NNP	Number=Sing	_	_	_	_
31	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	evolutionarily	evolutionarily	ADV	RB	_	_	_	_	_
34	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
47	C	C	PROPN	NNP	Number=Sing	_	_	_	_
48	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
49	3	3	NUM	CD	NumType=Card	_	_	_	_
50	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10663
# text = The I gamma 3 ECS lies upstream of the major I gamma 3 transcription initiation site and displays more than 90% identity with the corresponding human I gamma 1, I gamma 2, and I gamma 4 regions.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	3	3	NUM	CD	NumType=Card	_	_	_	_
5	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	_
6	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	%	%	SYM	NN	Number=Sing	_	_	_	_
23	identity	identity	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
27	human	human	AUX	MD	VerbForm=Fin	_	_	_	_
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
38	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
39	4	4	NUM	CD	NumType=Card	_	_	_	_
40	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10664
# text = Reporter luciferase gene vectors containing the human gamma 3 ECS were used to transfect CL-01 cells, which have been shown to undergo Smu-->S gamma 3 DNA recombination, upon engagement of CD40 by CD40 ligand (CD40L) and exposure to IL-4.
1	Reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
2	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	ECS	Ec	PROPN	NNP	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	transfect	transfect	VERB	VB	VerbForm=Inf	_	_	_	_
15	CL	Cl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	01	01	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	undergo	undergo	PROPN	NNP	Number=Sing	_	_	_	_
26	Smu	Smu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-->	-->	PUNCT	,	_	_	_	_	SpaceAfter=No
28	S	s	PROPN	NNP	Number=Sing	_	_	_	_
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	upon	upon	ADP	IN	_	_	_	_	_
35	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
40	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	CD40L	CD40L	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10665
# text = In these transfected CL-01 cells, CD40:CD40L engagement and exposure to IL-4 synergistically induced gamma 3 ECS-dependent luciferase reporter gene activation.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	CL	CL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	01	01	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	CD40:CD40L	Cd40:cd40l	PROPN	NNP	Number=Sing	_	_	_	_
10	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	4	for	NUM	CD	NumType=Card	_	_	_	_
17	synergistically	synergistically	ADV	RB	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10666
# text = Targeted mutational analysis demonstrated that a tandem NF-kappa B/Rel binding motif is critical for the gamma 3 ECS responsiveness to both CD40L and IL-4, while a STAT-6-binding site is additionally required for IL-4 inducibility.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	mutational	mutational	ADJ	JJ	Degree=Pos	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	_
22	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	_
23	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	CD40L	CD40L	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	while	while	SCONJ	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	additionally	additionally	ADV	RB	_	_	_	_	_
42	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	4	4	NUM	CD	NumType=Card	_	_	_	_
47	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10667
# text = Electrophoretic mobility shift assays showed that p50/p65/c-Rel and STAT-6 are effectively induced by CD40L and IL-4, respectively, and bind to specific DNA motifs within the ECS.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	ADV	RB	_	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	p50/p65/c	p50/p65/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	effectively	effectively	ADV	RB	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	CD40L	Cd40l	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	bind	bind	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
32	within	within	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10668
# text = These partially overlapping CD40L and IL-4 responsive elements are functionally cooperative as the disruption of one of them prevents synergistic promoter activation.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	partially	partially	ADV	RB	_	_	_	_	_
3	overlapping	overlapp	VERB	VBG	VerbForm=Ger	_	_	_	_
4	CD40L	Cd40l	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
10	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	functionally	functionally	ADV	RB	_	_	_	_	_
13	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	one	one	NUM	CD	NumType=Card	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
22	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10669
# text = Thus, the gamma 3 ECS is an inducible promoter containing cis elements that critically mediate CD40L and IL-4-triggered transcriptional activation of the human C gamma 3 gene.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	ECS	ECS	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	critically	critically	ADV	RB	_	_	_	_	_
16	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	C	C	PROPN	NNP	Number=Sing	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	3	3	NUM	CD	NumType=Card	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10670
# text = Document 0030012283 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012283	0030012283	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10671
# text = Transcriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	independently	independently	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10672
# text = BACKGROUND: IL-5 is fundamentally involved in eosinophilic inflammation.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	fundamentally	fundamentally	ADV	RB	_	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10673
# text = Control of IL-5 production may be effective for the management of allergic diseases.
1	Control	Control	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	management	management	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
15	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10674
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 10675
# text = We aimed to find the transcriptional mechanisms that regulate the IL-5 gene to selectively control IL-5 synthesis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	aimed	aim	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	selectively	selectively	ADV	RB	_	_	_	_	_
17	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	5	5	NUM	CD	NumType=Card	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10676
# text = METHODS: Allergen-specific T-cell clones and T-cell hybridomas were established from the peripheral blood lymphocytes of patients with asthma, and the transcriptional regulation of the IL-5 gene was investigated with transient transfection and electrophoretic mobility shift analysis.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Allergen	Allergen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	5	5	NUM	CD	NumType=Card	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
39	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
42	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
43	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
44	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10677
# text = RESULTS: A human IL-5 promoter/enhancer-luciferase gene construct, pIL-5(-511)Luc, was transcribed on activation of IL-5-producing T-cell clones, but not IL-5-nonproducing clones.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	pIL	pil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	(-511	(-511	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	Luc	Luc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
33	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	nonproducing	nonproducing	VERB	VBG	VerbForm=Ger	_	_	_	_
44	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10678
# text = pIL-5(-511)Luc was transcribed by T-cell hybridomas derived from fusion between IL-5-producing T-cell clones and an IL-5 gene-nonexpressing T-cell line, but not by hybridomas derived from IL-5-nonproducing T-cell clones.
1	pIL	pil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(-511	(-511	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	Luc	Luc	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	hybridomas	hybridoma	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	5	5	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	nonexpressing	nonexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
33	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	_
41	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	from	from	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	nonproducing	nonproducing	NOUN	NN	Number=Sing	_	_	_	_
48	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10679
# text = IL-5 synthesis was not only induced by T-cell receptor stimulation but also by IL-2 receptor stimulation.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	ADV	RB	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10680
# text = Binding of NF-AT, NF-kappaB, and AP-1 was induced by T-cell receptor (TcR) stimulation, although there was no significant upregulation of binding by IL-2 stimulation.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	although	although	SCONJ	IN	_	_	_	_	_
27	there	there	PRON	EX	_	_	_	_	_
28	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	no	no	DET	DT	_	_	_	_	_
30	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
31	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	SCONJ	IN	_	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10681
# text = CONCLUSION: IL-5 synthesis by human helper
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10682
# text = T cells is regulated at the transcriptional level.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10683
# text = A unique transcriptional mechanism distinct from those regulating the IL-2 or IL-4 genes seems to control the IL-5 gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10684
# text = Selective regulation of IL-5 gene transcription may be useful for treating eosinophlic inflammation.
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	eosinophlic	eosinophlic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10685
# text = Document 0030012284 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012284	0030012284	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10686
# text = Monochloramine inhibits phorbol ester-inducible neutrophil respiratory burst activation and T cell interleukin-2 receptor expression by inhibiting inducible protein kinase C activity.
1	Monochloramine	Monochloramine	PRON	PRP	_	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
4	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
7	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
8	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
9	burst	burst	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	T	t	NUM	CD	NumType=Card	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C	C	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10687
# text = Monochloramine derivatives are long lived physiological oxidants produced by neutrophils during the respiratory burst.
1	Monochloramine	Monochloramine	NOUN	NN	Number=Sing	_	_	_	_
2	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	long	long	ADV	RB	Degree=Pos	_	_	_	_
5	lived	live	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
7	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	_
8	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	respiratory	respiratory	ADJ	JJ	Degree=Pos	_	_	_	_
14	burst	burst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10688
# text = The effects of chemically prepared monochloramine (NH2Cl) on protein kinase C (PKC) and PKC-mediated cellular responses were studied in elicited rat peritoneal neutrophils and human Jurkat T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	chemically	chemically	ADV	RB	_	_	_	_	_
5	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	monochloramine	monochloramine	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NH2Cl	NH2Cl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
28	peritoneal	peritoneal	ADJ	JJ	Degree=Pos	_	_	_	_
29	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
33	T	T	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10689
# text = Neutrophils pretreated with NH2Cl (30-50 microM) showed a marked decrease in the respiratory burst activity induced by phorbol 12-myristate 13-acetate (PMA), which is a potent PKC activator.
1	Neutrophils	Neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
2	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	NH2Cl	NH2Cl	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	50	50	NUM	CD	NumType=Card	_	_	_	_
9	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	respiratory	respiratory	ADJ	JJ	Degree=Pos	_	_	_	_
18	burst	burst	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
26	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
37	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
38	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10690
# text = These cells, however, were viable and showed a complete respiratory burst upon arachidonic acid stimulation, which induces the respiratory burst by a PKC-independent mechanism.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	viable	viable	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
12	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
13	burst	burst	NOUN	NN	Number=Sing	_	_	_	_
14	upon	upon	ADP	IN	_	_	_	_	_
15	arachidonic	arachidonic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	respiratory	respiratory	ADJ	JJ	Degree=Pos	_	_	_	_
23	burst	burst	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
29	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10691
# text = The NH2Cl-treated neutrophils showed a decrease in both PKC activity and PMA-induced phosphorylation of a 47-kDa protein, which corresponds to the cytosolic factor of NADPH oxidase, p47(phox).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NH2Cl	NH2Cl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	corresponds	correspond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NADPH	NADPH	DET	DT	_	_	_	_	_
33	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	p47	p47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	phox	phox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10692
# text = Jurkat T cells pretreated with NH2Cl (20-70 microM) showed a decrease in the expression of the interleukin-2 receptor alpha chain following PMA stimulation.
1	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	NH2Cl	NH2Cl	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	70	70	NUM	CD	NumType=Card	_	_	_	_
11	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10693
# text = This was also accompanied by a decrease in both PKC activity and nuclear transcription factor-kappaB activation, also without loss of cell viability.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	without	without	ADP	IN	_	_	_	_	_
22	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	viability	viability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10694
# text = These results show that NH2Cl inhibits PKC-mediated cellular responses through inhibition of the inducible PKC activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NH2	NH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	Cl	Cl	NOUN	NN	Number=Sing	_	_	_	_
7	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
8	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
18	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10695
# text = Document 0030012289 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012289	0030012289	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10696
# text = Expression of IkappaBalpha in the nucleus of human peripheral blood T lymphocytes.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	T	t	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10697
# text = According to current models the inhibitory capacity of I(kappa)B(alpha) would be mediated through the retention of Rel/NF-kappaB proteins in the cytosol.
1	According	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
4	models	model	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	I	I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	retention	retention	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10698
# text = However, I(kappa)B(alpha) has also been detected in the nucleus of cell lines and when overexpressed by transient transfection.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	when	when	ADV	WRB	PronType=Int	_	_	_	_
23	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
26	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10699
# text = To gain better insight into the potential role of nuclear I(kappa)B(alpha) in a physiological context we have analysed its presence in the nucleus of human peripheral blood T lymphocytes (PBL).
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
4	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
22	context	context	NOUN	NN	Number=Sing	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
34	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	PBL	PBL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10700
# text = We demonstrate the nuclear localization of I(kappa)B(alpha) in PBL by different techniques: Western blot, indirect immunofluorescence and electron microscopy.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	techniques	technique	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
22	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
25	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	electron	electron	NOUN	NN	Number=Sing	_	_	_	_
28	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10701
# text = Low levels of nuclear
1	Low	low	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 10702
# text = I(kappa)B(alpha) were detected in resting cells whereas a superinduction was obtained after PMA activation.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	whereas	whereas	SCONJ	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	superinduction	superinduction	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10703
# text = The nuclear pool of I(kappa)B(alpha) showed a higher stability than cytosolic I(kappa)B(alpha) and was partially independent of the resynthesis of the protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	pool	pool	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
16	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	cytosolic	cytosolic	NOUN	NN	Number=Sing	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	partially	partially	ADV	RB	_	_	_	_	_
30	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	resynthesis	resynthesis	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10704
# text = Unexpectedly, the presence of nuclear
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 10705
# text = I(kappa)B(alpha) did not inhibit NF-kappaB binding to DNA and this phenomenon was not due to the presence of IkappaBbeta at the nuclear level.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	due	due	ADP	IN	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10706
# text = Immunoprecipitation experiments failed to demonstrate an association between nuclear
1	Immunoprecipitation	Immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	association	association	NOUN	NN	Number=Sing	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 10707
# text = I(kappa)B(alpha) and NF-kappaB proteins.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10708
# text = Our results demonstrate that in resting and PMA-activated human PBL, I(kappa)B(alpha) is present in the nucleus in an apparently inactive form unable to disrupt NF-kappaB binding from DNA.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADV	RB	_	_	_	_	_
6	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	apparently	apparently	ADV	RB	_	_	_	_	_
30	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
31	form	form	NOUN	NN	Number=Sing	_	_	_	_
32	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10709
# text = Document 0030012290 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012290	0030012290	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10710
# text = Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.
1	Tolerance	Tolerance	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	lipopolysaccharide	lipopolysaccharide	VERB	VB	VerbForm=Inf	_	_	_	_
4	involves	involves	NOUN	NNS	Number=Plur	_	_	_	_
5	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	predominance	predominance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10711
# text = Stimulation of the human monocytic cell line Mono Mac 6 with lipopolysaccharide (LPS) leads to rapid and transient expression of cytokines like tumor necrosis factor (TNF).
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
9	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
24	like	like	ADP	IN	_	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10712
# text = When such cells are precultured for 2 days with a low dose of LPS (20 ng/ml) followed by stimulation with a high dose of LPS (1 microgram/ml), expression of the TNF gene is minimal, i.e. the cells are tolerant.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	precultured	preculture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	days	day	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	20	20	NUM	CD	NumType=Card	_	_	_	_
17	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	microgram	microgram	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	i.e.	i.e.	X	FW	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
49	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10713
# text = In nuclear run-on analysis, such tolerant cells show only a low degree of transcription, indicating that tolerance operates at or upstream of the transcription level.
1	In	in	ADP	IN	_	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	on	on	ADP	IN	_	_	_	_	_
6	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
9	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
15	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
22	operates	operate	NOUN	NNS	Number=Plur	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10714
# text = The CD14 LPS receptor is, however, up-regulated (not down-regulated) in tolerant cells, and LPS can, in fact, still lead to activation of tolerant cells as evidenced by mobilization of the transcription factor nuclear factor kappa B (NF-kappa B).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	14	14	NUM	CD	NumType=Card	_	_	_	_
4	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulated	regulated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	not	not	PART	RB	_	_	_	_	_
15	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	still	still	ADV	RB	_	_	_	_	_
31	lead	lead	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	as	as	SCONJ	IN	_	_	_	_	_
38	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
46	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
47	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
48	B	b	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
53	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10715
# text = Resolution of the NF-kappa B complex in gel shift analysis shows that the binding protein, mobilized in naive Mono Mac 6 cells, consists mainly of p50-p65 heterodimers, while in tolerant cells, the p50 homodimer is predominant.
1	Resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
11	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
12	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
13	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	mobilized	mobilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
22	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
23	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
24	6	6	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	mainly	mainly	ADV	RB	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	p65	p65	NUM	CD	NumType=Card	_	_	_	_
33	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	while	while	SCONJ	IN	_	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
42	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
43	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10716
# text = This increase in p50 homodimers coincides with an increase in p105 mRNA, suggestive of a transcriptional up-regulation of p50.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
6	coincides	coincide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	p105	p105	NUM	CD	NumType=Card	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	suggestive	suggestive	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10717
# text = Reporter gene analysis reveals that the NF-kappa B complex mobilized in tolerant cells is functionally inactive in that NF-kappa B-dependent luciferase constructs containing the human immunodeficiency virus long terminal repeat or the TNF 5'-region show only minimal transactivation after LPS stimulation.
1	Reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	mobilized	mobilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	functionally	functionally	ADV	RB	_	_	_	_	_
18	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
28	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
29	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
33	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
34	long	long	ADV	RB	Degree=Pos	_	_	_	_
35	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
36	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
40	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	region	region	NOUN	NN	Number=Sing	_	_	_	_
44	show	show	NOUN	NN	Number=Sing	_	_	_	_
45	only	only	ADV	RB	_	_	_	_	_
46	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
47	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
48	after	after	ADP	IN	_	_	_	_	_
49	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
50	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10718
# text = Similar to Mono Mac 6 cells, primary blood monocytes, when precultured with a low dose of LPS, also become tolerant and produce little TNF after LPS stimulation.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
4	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	precultured	preculture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	tolerant	tolerant	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
26	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
27	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
28	after	after	ADP	IN	_	_	_	_	_
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10719
# text = The tolerant blood monocytes also up-regulate CD14, and they mobilize NF-kappa B with a predominance of p50 homodimers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
13	mobilize	mobilize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	predominance	predominance	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p50	p50	NUM	CD	NumType=Card	_	_	_	_
23	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10720
# text = Taken together, these results demonstrate that tolerance to LPS is determined by post-receptor mechanisms that involve an altered composition of the NF-kappa B complex.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	post	post	X	AFX	_	_	_	_	SpaceAfter=No
15	-receptor	-receptor	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10721
# text = Document 0030012299 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012299	0030012299	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10722
# text = Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	NFAT1	nfat1	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	P0	P0	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
35	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10723
# text = Allergen-specific T cells in atopic patients are polarized IL-4-producing Th2 cells, promoting IgE synthesis by B cells.
1	Allergen	Allergen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	polarized	polarize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
20	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10724
# text = The molecular basis for increased IL-4 gene expression in atopy is not fully understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	atopy	atopy	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	fully	fully	ADV	RB	_	_	_	_	_
16	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10725
# text = IL-4 gene regulation in general involves the nuclear factor of activated T cells (NFAT) family of transcription factors, of which NFAT1 and NFAT2 are most prominent in peripheral T cells.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
8	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	NFAT1	nfat1	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	NFAT2	Nfat2	NUM	CD	NumType=Card	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	most	most	ADV	RBS	_	_	_	_	_
31	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10726
# text = Recently, a unique inhibitory role of NFAT1 in IL-4 gene control was shown in the mouse.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	control	control	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10727
# text = In a series of electrophoretic mobility shift assays with protein extracts of highly polarized
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	series	series	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
6	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
7	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
8	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	polarized	polarize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 10728
# text = Th2 clones from atopics and Th1 clones from controls we compared DNA-binding activities at the two NFAT-binding elements P0 and P1 of the crucial proximal human IL-4 promoter.
1	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
2	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	atopics	atopic	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
7	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	controls	controls	NOUN	NNS	Number=Plur	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	P0	P0	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	P1	P1	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
29	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10729
# text = At the most proximal P0 site, NFAT-containing complexes devoid of NFAT2 were readily inducible in the Th1 clones, but hardly or not in the Th2 clones.
1	At	at	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	most	most	ADV	RBS	_	_	_	_	_
4	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
5	P0	P0	NOUN	NN	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	NFAT	NFAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	devoid	devoid	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFAT2	NFAT2	NUM	CD	NumType=Card	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	readily	readily	ADV	RB	_	_	_	_	_
17	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Th1	th1	NOUN	NN	Number=Sing	_	_	_	_
21	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	hardly	hardly	ADV	RB	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Th2	Th2	NOUN	NN	Number=Sing	_	_	_	_
30	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10730
# text = In contrast, both in Th1 and Th2 clones NFAT-containing complexes were strongly inducible at the P1 site, consisting of NFAT2 and a P0-compatible NFAT activity, without apparent differences between Th1 and Th2 clones.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
9	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
10	NFAT	Nfat	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
13	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	strongly	strongly	ADV	RB	_	_	_	_	_
16	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	P1	P1	PROPN	NNP	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NFAT2	NFAT2	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	P0-	p0-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
29	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	without	without	ADP	IN	_	_	_	_	_
33	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
34	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
35	between	between	ADP	IN	_	_	_	_	_
36	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
39	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10731
# text = Like in Th2 clones, suppressed NFAT-P0 complex formation was observed also at the polyclonal level in peripheral blood mononuclear cells (PBMC) of three of five severe atopic dermatitis patients with strongly elevated serum IgE levels, but not in control PBMC.
1	Like	like	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	P0	P0	PROPN	NNP	Number=Sing	_	_	_	_
10	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
11	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
21	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
22	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PBMC	PBMC	X	LS	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	three	three	NUM	CD	NumType=Card	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	five	five	NUM	CD	NumType=Card	_	_	_	_
31	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
32	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
33	dermatitis	dermatitis	NOUN	NN	Number=Sing	_	_	_	_
34	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	strongly	strongly	ADV	RB	_	_	_	_	_
37	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
39	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
40	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	but	but	CCONJ	CC	_	_	_	_	_
43	not	not	ADV	RB	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	control	control	NOUN	NN	Number=Sing	_	_	_	_
46	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10732
# text = These findings suggest that high-level IL-4 production in atopic
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	atopic	atopic	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10733
# text = Th2 cells is associated with selective reduction of suppressive NFAT1 activity at the IL-4 P0 element and that some patients with this multifactorial disease may have a putative systemic disorder at this level.
1	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
7	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	NFAT1	NFAT1	NUM	CD	NumType=Card	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	P0	P0	NUM	CD	NumType=Card	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	some	some	DET	DT	_	_	_	_	_
22	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	multifactorial	multifactorial	ADJ	JJ	Degree=Pos	_	_	_	_
26	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
31	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
32	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10734
# text = Document 0030012307 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012307	0030012307	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10735
# text = Platelet-activating factor induces phospholipid turnover, calcium flux, arachidonic acid liberation, eicosanoid generation, and oncogene expression in a human B cell line.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
6	phospholipid	phospholipid	ADJ	JJ	Degree=Pos	_	_	_	_
7	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
10	flux	flux	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	arachidonic	arachidonic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	liberation	liberation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	eicosanoid	eicosanoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10736
# text = Platelet-activating factor is a potent mediator of the inflammatory response.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
8	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10737
# text = Studies of the actions of platelet-activating factor have centered mainly around neutrophils, monocytes, and platelets.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	centered	center	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	mainly	mainly	ADV	RB	_	_	_	_	_
13	around	around	ADP	IN	_	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10738
# text = In this report we begin to uncover the influence of platelet-activating factor on B lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	begin	begin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	uncover	uncover	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10739
# text = Employing the EBV-transformed human B cell line SKW6.4, we demonstrate that platelet-activating factor significantly alters membrane phospholipid metabolism indicated by the incorporation of 32P into phosphatidylcholine, phosphatidylinositol, and phosphatidic acid but not significantly into phosphatidylethanolamine at concentrations ranging from 10(-9) to 10(-6) M.
1	Employing	Employ	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	SKW6.4	Skw6.4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	alters	alter	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	membrane	membrane	PRON	NN	Number=Sing	_	_	_	_
22	phospholipid	phospholipid	ADJ	JJ	Degree=Pos	_	_	_	_
23	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	_
24	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	32P	32p	NOUN	NN	Number=Sing	_	_	_	_
30	into	into	ADP	IN	_	_	_	_	_
31	phosphatidylcholine	phosphatidylcholine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	phosphatidic	phosphatidic	ADJ	JJ	Degree=Pos	_	_	_	_
37	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
38	but	but	CCONJ	CC	_	_	_	_	_
39	not	not	ADV	RB	_	_	_	_	_
40	significantly	significantly	ADV	RB	_	_	_	_	_
41	into	into	ADP	IN	_	_	_	_	_
42	phosphatidylethanolamine	phosphatidylethanolamine	NOUN	NN	Number=Sing	_	_	_	_
43	at	at	ADP	IN	_	_	_	_	_
44	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
45	ranging	range	VERB	VBG	VerbForm=Ger	_	_	_	_
46	from	from	ADP	IN	_	_	_	_	_
47	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
49	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	(-6	(-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	_
55	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10740
# text = The inactive precursor, lyso-platelet-activating factor, at a concentration as high as 10(-7) M had no effect on any of the membrane phospholipids.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
3	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	lyso	lyso	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
20	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	M	m	NOUN	NN	Number=Sing	_	_	_	_
23	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	no	no	DET	DT	_	_	_	_	_
25	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	any	any	DET	DT	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
31	phospholipids	phospholipid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10741
# text = We also show that platelet-activating factor from 10(-12) to 10(-6) M induced rapid and significant elevation in intracellular calcium levels, whereas lyso-platelet-activating factor was again ineffective.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(-12	(-12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	(-6	(-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	M	be	NOUN	NN	Number=Sing	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	whereas	whereas	SCONJ	IN	_	_	_	_	_
29	lyso	lyso	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-platelet	-platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	again	again	ADV	RB	_	_	_	_	_
36	ineffective	ineffective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10742
# text = We further demonstrate the impact of platelet-activating factor binding to B cells by measuring platelet-activating factor induced arachidonic acid release and 5-hydroxyeicosatetraenoic acid production.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	impact	impact	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	measuring	measure	VERB	VBG	VerbForm=Ger	_	_	_	_
17	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	arachidonic	arachidonic	ADJ	JJ	Degree=Pos	_	_	_	_
23	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	hydroxyeicosatetraenoic	hydroxyeicosatetraenoic	ADJ	JJ	Degree=Pos	_	_	_	_
29	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
30	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10743
# text = Moreover, platelet-activating factor was capable of inducing transcription of the nuclear proto-oncogenes c-fos and c-jun.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
17	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10744
# text = Finally we explored the possible role of 5-hydroxyeicosatetraenoic acid as a regulator of arachidonic acid liberation demonstrating that endogenous 5-lipoxygenase activity modulates platelet-activating factor induced arachidonic acid release perhaps acting at the level of phospholipase A2.
1	Finally	finally	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	explored	explore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	hydroxyeicosatetraenoic	hydroxyeicosatetraenoic	NOUN	NN	Number=Sing	_	_	_	_
11	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	arachidonic	arachidonic	ADJ	JJ	Degree=Pos	_	_	_	_
17	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
18	liberation	liberation	NOUN	NN	Number=Sing	_	_	_	_
19	demonstrating	demonstrating	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	modulates	modulate	NOUN	NNS	Number=Plur	_	_	_	_
27	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	arachidonic	arachidonic	ADJ	JJ	Degree=Pos	_	_	_	_
33	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
34	release	release	NOUN	NN	Number=Sing	_	_	_	_
35	perhaps	perhaps	ADV	RB	_	_	_	_	_
36	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	level	level	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
42	A2	a2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10745
# text = In summary, platelet-activating factor is shown here to have a direct and profound effect on a pure B cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	here	here	ADV	RB	PronType=Dem	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	pure	pure	ADJ	JJ	Degree=Pos	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10746
# text = Document 0030012308 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012308	0030012308	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10747
# text = Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
12	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10748
# text = Previous studies have implicated a role for intracellular thiols in the activation of nuclear factor-kappaB and transcriptional regulation of endothelial cell adhesion molecules.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	thiols	thiol	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
25	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10749
# text = This study was designed to determine whether changes in endothelial cell glutathione (GSH) or oxidized glutathione (GSSG) can alter neutrophil adhesivity and to define the molecular mechanism that underlies this GSSG/GSH-induced adhesion response.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	GSH	GSH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
24	neutrophil	neutrophil	ADP	IN	_	_	_	_	_
25	adhesivity	adhesivity	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
31	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	underlies	underly	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	GSSG/GSH	GSSG/GSh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10750
# text = Treatment of human umbilical vein endothelial cell (HUVEC) monolayers for 6 hours with 0.2 mmol/L diamide and 1 mmol/L buthionine sulfoximine (BSO) decreased GSH levels and increased the ratio of GSSG to GSH without cell toxicity.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
5	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HUVEC	HUVEC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	monolayers	monolayer	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	0.2	0.2	NUM	CD	NumType=Card	_	_	_	_
17	mmol/L	mmol/l	NOUN	NN	Number=Sing	_	_	_	_
18	diamide	diamide	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	mmol/L	mmol/l	NOUN	NN	Number=Sing	_	_	_	_
22	buthionine	buthionine	NUM	CD	NumType=Card	_	_	_	_
23	sulfoximine	sulfoximine	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	BSO	BSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	GSH	Gsh	ADJ	JJ	Degree=Pos	_	_	_	_
29	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	GSH	Gsh	VERB	VB	VerbForm=Inf	_	_	_	_
38	without	without	ADP	IN	_	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	toxicity	toxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10751
# text = These redox changes are similar to those observed with anoxia/reoxygenation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	anoxia	anoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10752
# text = Diamide plus BSO-induced thiol/disulfide imbalance was associated with a biphasic increase in neutrophil adhesion to HUVECs with peak responses observed at 15 minutes (phase 1) and 240 minutes (phase 2).
1	Diamide	Diamide	PROPN	NNP	Number=Sing	_	_	_	_
2	plus	plus	CCONJ	CC	_	_	_	_	_
3	BSO	Bso	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	disulfide	disulfide	NOUN	NN	Number=Sing	_	_	_	_
9	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
23	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
24	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	15	15	NUM	CD	NumType=Card	_	_	_	_
27	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
30	1	1	X	LS	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	240	240	NUM	CD	NumType=Card	_	_	_	_
34	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10753
# text = N-Acetylcysteine treatment attenuated neutrophil adhesion in both phases, which indicated a role for GSH in the adhesion responses.
1	N	not	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Acetylcysteine	Acetylcysteine	ADJ	JJ	Degree=Pos	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	neutrophil	neutrophil	ADP	IN	_	_	_	_	_
7	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	phases	phase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
21	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10754
# text = Interestingly, phase 1 adhesion was inversely correlated with GSH levels but not with the GSSG/GSH ratio, whereas phase 2 neutrophil adhesion was positively correlated with GSSG/GSH ratio but not with GSH levels.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inversely	inversely	ADV	RB	_	_	_	_	_
8	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	GSH	Gsh	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	GSSG	Gssg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	GSH	Gsh	PROPN	NNP	Number=Sing	_	_	_	_
19	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	positively	positively	ADV	RB	_	_	_	_	_
28	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	GSH	Gsh	PROPN	NNP	Number=Sing	_	_	_	_
33	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	GSH	Gsh	DET	DT	_	_	_	_	_
38	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10755
# text = Intercellular adhesion molecule-1 and P-selectin-specific monoclonal antibodies attenuated the increased neutrophil adhesion during both phases, whereas an anti-E-selectin monoclonal antibody also attenuated the phase 2 response.
1	Intercellular	Intercelular	ADJ	JJ	Degree=Pos	_	_	_	_
2	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	P-selectin-specific	P-selectin-specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
10	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	phases	phase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	anti-E-	anti-E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
24	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10756
# text = Pretreatment with actinomycin D and cycloheximide or with competing ds-oligonucleotides that contained nuclear factor-kappaB or activator protein-1 cognate DNA sequences significantly attenuated the phase 2 response, which implicated a role for de novo protein synthesis.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	actinomycin	actinomycin	NOUN	NN	Number=Sing	_	_	_	_
4	D	d	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	with	with	SCONJ	IN	_	_	_	_	_
9	competing	compete	VERB	VBG	VerbForm=Ger	_	_	_	_
10	ds	d	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	cognate	cognate	NOUN	NN	Number=Sing	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
27	significantly	significantly	ADV	RB	_	_	_	_	_
28	attenuated	attenuate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	implicated	implicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	role	role	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	de	de	PROPN	NNP	Number=Sing	_	_	_	_
40	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
42	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10757
# text = Surface expression of intercellular adhesion molecule-1, P-selectin, and E-selectin on HUVECs correlated with the phase 1 and 2 neutrophil adhesion responses.
1	Surface	surface	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	P-selectin	P-selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
17	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10758
# text = This study demonstrates that changes in endothelial cell GSSG/GSH cause transcription-independent and transcription-dependent surface expression of different endothelial cell adhesion molecules, which leads to a 2-phase neutrophil-endothelial adhesion response.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	GSH	Gsh	ADJ	JJ	Degree=Pos	_	_	_	_
12	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
36	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
39	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10759
# text = Document 0030012311 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012311	0030012311	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10760
# text = Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.
1	Alpha	Alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	cultured	cultured	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10761
# text = Antioxidants have been proposed to be anti-atherosclerotic agents; however, the mechanisms underlying their beneficial effects are poorly understood.
1	Antioxidants	Antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	anti-atherosclerotic	anti-atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
8	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	;	;	PUNCT	,	_	_	_	_	_
10	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
14	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	poorly	poorly	ADV	RB	_	_	_	_	_
20	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10762
# text = We have examined the effect of alpha-tocopherol (alpha-tcp) on one cellular event in atherosclerotic plaque development, monocyte adhesion to stimulated endothelial cells (ECs).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	tocopherol	tocopherol	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	tcp	tcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	event	event	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	plaque	plaque	NOUN	NN	Number=Sing	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	stimulated	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
28	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10763
# text = Human umbilical vein ECs were pretreated with alpha-tcp before stimulation with known agonists of monocyte adhesion: IL-1 (10 ng/ml), LPS (10 ng/ml), thrombin (30 U/ml), or PMA (10 nM).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
3	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
4	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	tcp	tcp	NOUN	NN	Number=Sing	_	_	_	_
11	before	before	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	10	10	NUM	CD	NumType=Card	_	_	_	_
25	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	10	10	NUM	CD	NumType=Card	_	_	_	_
32	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	thrombin	thrombin	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	30	30	NUM	CD	NumType=Card	_	_	_	_
39	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	10	10	NUM	CD	NumType=Card	_	_	_	_
47	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10764
# text = Agonist-induced monocytic cell adhesion, but not basal adhesion, was inhibited in a time- and concentration-dependent manner by alpha-tcp.
1	Agonist	Agonist	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
10	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	tcp	tcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10765
# text = The IC50 of alpha-tcp on an IL-1-induced response was 45 microM.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IC50	IC50	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	tcp	tcp	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	45	45	NUM	CD	NumType=Card	_	_	_	_
17	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10766
# text = The inhibition correlated with a decrease in steady state levels of E-selectin mRNA and cell surface expression of E-selectin which is consistent with the ability of a monoclonal antibody to E-selectin to inhibit monocytic cell adhesion in this system.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
9	state	state	NOUN	NN	Number=Sing	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
31	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	E-	E-	X	GW	_	_	_	_	SpaceAfter=No
34	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
37	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10767
# text = Probucol (50 microM) and N-acetylcysteine (20 mM) also inhibited agonist-induced monocytic cell adhesion; whereas, several other antioxidants had no significant effect.
1	Probucol	Probucol	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	50	50	NUM	CD	NumType=Card	_	_	_	_
4	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	20	20	NUM	CD	NumType=Card	_	_	_	_
11	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
27	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	no	no	DET	DT	_	_	_	_	_
29	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10768
# text = Protein kinase C (PKC) does not appear to play a role in the alpha-tcp effect since no suppression of phosphorylation of PKC substrates was observed.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	tcp	tcp	NOUN	NN	Number=Sing	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	since	since	ADP	IN	_	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
27	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10769
# text = Activation of the transcription factor NF-kappa B is reported to be necessary but not sufficient for E-selectin expression in EC.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10770
# text = Electrophoretic mobility shift assays failed to show an alpha-tcp-induced decrease in activation of this transcription factor after cytokine stimulation.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	alpha-	alpha-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	tcp-induced	tcp-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10771
# text = It has been hypothesized that alpha-tcp acts as an anti-atherosclerotic molecule by inhibiting generation of oxidized LDL--a putative triggering molecule in the atherosclerotic process.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	hypothesized	hypothesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	tcp	tcp	NOUN	NN	Number=Sing	_	_	_	_
9	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	anti-atherosclerotic	anti-atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
13	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
16	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	oxidized	oxidized	ADJ	JJ	Degree=Pos	_	_	_	_
19	LDL	LDL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
23	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
28	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10772
# text = Our results point to a novel alternative mechanism of action of alpha-tcp.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	point	point	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	alternative	alternative	NOUN	NN	Number=Sing	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	tcp.	tcp.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10773
# text = Document 0030012317 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012317	0030012317	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10774
# text = CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
1	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-mediated	-mediated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10775
# text = During the course of serious bacterial infections, lipopolysaccharide (LPS) is believed to interact with macrophage receptors, resulting in the generation of inflammatory mediators and systemic symptoms including hemodynamic instability and shock.
1	During	during	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	course	course	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	serious	serious	ADJ	JJ	Degree=Pos	_	_	_	_
6	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
7	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
30	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	hemodynamic	hemodynamic	ADJ	JJ	Degree=Pos	_	_	_	_
33	instability	instability	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10776
# text = CD14, a glycosylphosphatidylinositol-linked antigen, functions as an LPS signaling receptor.
1	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10777
# text = A critical issue concerns the mechanism by which CD14, which has no transmembrane domain, transduces its signal following LPS binding.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
3	issue	issue	NOUN	NN	Number=Sing	_	_	_	_
4	concerns	concern	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	transduces	transduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
20	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
21	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10778
# text = Recently, investigators have hypothesized that CD14-mediated signaling is effected through a receptor-associated tyrosine kinase (TK), suggesting a multicomponent receptor model of LPS signaling.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	investigators	investigator	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	hypothesized	hypothesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	CD14	Cd14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
9	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	effected	effect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TK	TK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	multicomponent	multicomponent	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	model	model	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
30	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10779
# text = Wild-type Chinese hamster ovary (CHO)-K1 cells can be activated by endotoxin to release arachidonate following transfection with human CD14 (CHO/CD14).
1	Wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	type	type	NOUN	NN	Number=Sing	_	_	_	_
4	Chinese	chinese	ADJ	JJ	Degree=Pos	_	_	_	_
5	hamster	hamster	NOUN	NN	Number=Sing	_	_	_	_
6	ovary	ovary	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CHO	Cho	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	K1	K1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
20	arachidonate	arachidonate	NOUN	NN	Number=Sing	_	_	_	_
21	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
22	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	CHO/CD	CHO/CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10780
# text = Nuclear translocation of cytosolic NF-kappa B is correlated with a number of LPS-inducible responses.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	number	number	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
18	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10781
# text = We sought to determine if this pathway were present in CHO/CD14 cells and to elucidate the relationship of NF-kappa B activation to the CD14 receptor system.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	if	if	SCONJ	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	CHO/CD	Cho/cd	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	14	14	NUM	CD	NumType=Card	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10782
# text = LPS-stimulated translocation of NF-kappa B in CHO/CD14 cells resembled the same response in the murine macrophage-like cell line RAW 264.7.
1	LPS	Lps	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	CHO/CD	Cho/cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	resembled	resemble	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	_
26	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
27	264.7	264.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10783
# text = Protein synthesis inhibitors and corticosteroids, which suppress arachidonate release and the synthesis of proinflammatory cytokines, had no effect on translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, demonstrating that NF-kappa B translocation is an early event.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	corticosteroids	corticosteroid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	suppress	suppress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	arachidonate	arachidonate	ADJ	JJ	Degree=Pos	_	_	_	_
10	release	release	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	no	no	DET	DT	_	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	CHO/CD14	CHO/CD14	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
32	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
42	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
45	event	event	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10784
# text = Although TK activity was consistently observed by immunoblotting extracts from activated RAW 264.7 cells, LPS-induced phosphotyrosine residues were not observed from similarly treated CHO/CD14 cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	TK	TK	PROPN	NNP	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	consistently	consistently	ADV	RB	_	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
9	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
13	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	phosphotyrosine	phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	similarly	similarly	ADV	RB	_	_	_	_	_
26	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	CHO/CD	Cho/cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	14	14	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10785
# text = Furthermore, the TK inhibitors herbimycin A and genistein failed to inhibit translocation of NF-kappa B in CHO/CD14 or RAW 264.7 cells, although both of these agents inhibited LPS-induced TK activity in RAW 264.7 cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	TK	TK	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibitors	inhibitor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	herbimycin	herbimycin	ADJ	JJ	Degree=Pos	_	_	_	_
7	A	a	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	_
10	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	CHO/CD14	CHO/CD14	PROPN	NNP	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
23	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	although	although	SCONJ	IN	_	_	_	_	_
27	both	both	DET	DT	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
31	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	TK	TK	PROPN	NNP	Number=Sing	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	_
39	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10786
# text = These results imply that TK activity is not obligatory for CD14-mediated signal transduction to occur in response to LPS.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TK	TK	PROPN	NNP	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	obligatory	obligatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	CD14	CD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
15	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10787
# text = Document 0030012318 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012318	0030012318	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10788
# text = Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat.
1	Itk	Itk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	CD2	CD2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10789
# text = We investigated the functional role of Itk, a member of the cytoplasmic tyrosine kinase Tec family, in T cell activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Itk	Itk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	member	member	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	Tec	Tec	PROPN	NNP	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10790
# text = Stimulation of either CD2 or T cell receptor (TCR)/CD3 on Tcells by monoclonal antibody-mediated cross-linking induced tyrosine phosphorylation of Itk, which was maximal as early as 1 min after stimulation.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	either	either	CCONJ	CC	_	_	_	_	_
4	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TCR)	TCR)	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/CD3	/CD3	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	Tcells	Tcells	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Itk	Itk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
30	as	as	ADV	RB	_	_	_	_	_
31	early	early	ADV	RB	Degree=Pos	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	min	min	NOUN	NNS	Number=Plur	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10791
# text = The tyrosine kinase activity in the anti-Itk immunoprecipitate was significantly activated upon these stimulations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
8	-Itk	-Itk	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunoprecipitate	immunoprecipitate	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	upon	upon	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	stimulations	stimulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10792
# text = Interleukin-2 (IL-2) promoter activity stimulated by cross-linking of CD2, TCR/CD3, and CD28 with antibodies was significantly reduced by transient expression of an Itk mutant lacking the kinase activity.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	TCR/CD3	TCR/CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	Itk	Itk	PROPN	NNP	Number=Sing	_	_	_	_
33	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
34	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10793
# text = The reduction paralleled a decrease in tyrosine phosphorylation of endogenous wild-type Itk.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	paralleled	parallel	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	Itk	Itk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10794
# text = Stimulation of CD2 or TCR/CD3 induced activation of the nuclear factor of activated T cells (NFAT), the binding site of which is included in the IL-2 gene promoter.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	TCR/	TCR/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	included	include	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10795
# text = The activation of NFAT was also impaired by expression of the Itk mutant.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Itk	Itk	PROPN	NNP	Number=Sing	_	_	_	_
13	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10796
# text = These results demonstrate that Itk plays a role in IL-2 production, indicating a critical involvement of Itk in the initial stage of T cell activation by mediating signals from the TCR/CD3 complex, CD2, and CD28.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Itk	Itk	PROPN	NNP	Number=Sing	_	_	_	_
6	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Itk	Itk	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
24	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
31	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	TCR/CD3	TCR/CD3	NOUN	NN	Number=Sing	_	_	_	_
35	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10797
# text = Document 0030012321 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012321	0030012321	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10798
# text = Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
15	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10799
# text = To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene, we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor, designated NF-microB, in the murine IgH enhancer.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	highly	highly	ADV	RB	_	_	_	_	_
11	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	OCTA	OCTA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	nucleotide	nucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
18	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
29	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
38	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	SCONJ	IN	_	_	_	_	_
43	mutating	mutat	VERB	VBG	VerbForm=Ger	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
46	site	site	NOUN	NN	Number=Sing	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
50	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
51	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	microB	microB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
65	IgH	Igh	ADP	IN	_	_	_	_	_
66	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10800
# text = We demonstrate that the NF-microB-binding site plays a critical role in the IgH enhancer, because mutation of the microB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the B-cell lineage but not in nonlymphoid cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	microB	microb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	because	because	SCONJ	IN	_	_	_	_	_
21	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	microB	microB	PROPN	NNP	Number=Sing	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
27	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
33	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
42	but	but	CCONJ	CC	_	_	_	_	_
43	not	not	PART	RB	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10801
# text = This effect was comparable to or even stronger than the effect of a mutation in the OCTA site.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	even	even	ADV	RB	_	_	_	_	_
8	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
9	than	than	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	OCTA	OCTA	PROPN	NNP	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10802
# text = Moreover, combined mutation of both microB and OCTA sites further reduced enhancer activity in lymphoid cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	microB	microB	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	OCTA	OCTA	PROPN	NNP	Number=Sing	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	further	further	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10803
# text = Interestingly, alteration of either the microB or E3 site in a 70-base-pair fragment of the IgH enhancer that lacks the binding site for OCTA abolished enhancer activity in lymphoid cells completely.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	either	either	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	microB	microb	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	E3	E3	NUM	CD	NumType=Card	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	base	base	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
18	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IgH	Igh	ADJ	JJ	Degree=Pos	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	OCTA	OCTA	PROPN	NNP	Number=Sing	_	_	_	_
30	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	completely	completely	ADV	RB	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10804
# text = Nevertheless, a multimer of the microB motif alone showed no enhancer activity.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	multimer	multimer	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	microB	microB	PROPN	NNP	Number=Sing	_	_	_	_
8	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
9	alone	alone	ADV	RB	_	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10805
# text = DNase footprinting analysis corroborated the functional data showing that a lymphoid-specific protein binds to the microB DNA motif.
1	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
2	footprinting	footprint	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	corroborated	corroborate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	data	data	NOUN	NN	Number=Sing	_	_	_	_
8	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	microB	microB	PROPN	NNP	Number=Sing	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10806
# text = Our results suggest that the microB element is a new crucial element important for lymphoid-specific expression of the IgH gene but that interaction with another enhancer element is essential for its activity.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	microB	microb	NOUN	NN	Number=Sing	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
11	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IgH	Igh	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	another	another	DET	DT	_	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	element	element	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10807
# text = Document 0030012328 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012328	0030012328	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10808
# text = Molecular regulation of cytokine gene expression during the immune response.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10809
# text = Cytokine expression by immune system cells plays an important role in the regulation of the immune response.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
5	system	system	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10810
# text = On first encounter with antigen, naive CD4+ T helper (Th) cells differentiate into cytokine-producing effector cells.
1	On	on	ADP	IN	_	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	encounter	encounter	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
8	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	T	t	NUM	CD	NumType=Card	_	_	_	_
11	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Th	th	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	differentiate	differentiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
21	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10811
# text = Two types of effector cells characterized by their distinct expression of cytokine profiles have been described.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	types	type	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10812
# text = Th1 cells produce IL-2 and IFN-gamma, whereas Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13.
1	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-4	-4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10813
# text = In many pathological situations, the balance between Th1 and Th2 immune responses determines the outcome of diverse immunologically mediated clinical syndromes including infectious, autoimmune, and allergic diseases.
1	In	in	ADP	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
4	situations	situation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
14	determines	determine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	outcome	outcome	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
19	immunologically	immunologically	ADV	RB	_	_	_	_	_
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
22	syndromes	syndrome	NOUN	NNS	Number=Plur	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	autoimmune	autoimmune	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
30	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10814
# text = However, the molecular basis for the tissue-specific expression of Th1/Th2-like cytokines has remained elusive.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Th1	Th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
15	Th2	Th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-like	-like	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	remained	remain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	elusive	elusive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10815
# text = In this review we evaluate the possible in vivo role of different transcription factors and transcriptional mechanisms in T cell differentiation and the immune response.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	evaluate	evaluate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10816
# text = Document 0030012330 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012330	0030012330	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10817
# text = Characterization of NF(P), the nuclear factor that interacts with the regulatory P sequence (5'-CGAAAATTTCC-3') of the human interleukin-4 gene: relationship to NF-kappa B and NF-AT.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	P	p	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	5'-CGAAAATTTCC	5'-cgaaaatttcc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	:	:	PUNCT	:	_	_	_	_	_
32	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10818
# text = The P sequence of the human interleukin-4 (IL-4) gene, which was defined as a responsive element for phorbol 12-myristate 13-acetate and calcium ionophore (A23187) in Jurkat
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	P	p	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
26	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
29	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
34	ionophore	ionophore	ADV	RB	_	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	A23187	A23187	X	LS	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 10819
# text = T cells, shares sequence similarity with the NF-kappa B and the NF-AT binding sites.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	shares	share	NOUN	NNS	Number=Plur	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	AT	AT	SCONJ	IN	_	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10820
# text = We examined whether NF(P), a nuclear factor specific for the P sequence, is related to NF-kappa B and NF-AT.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	P	P	NOUN	NN	Number=Sing	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10821
# text = NF-kappa B (P65 or P65/P50 heterodimer) bound to the P sequence in electrophoretic mobility shift assays (EMSA) and activated transcription through the P sequence when expression plasmids were cotransfected with P sequence-driven reporter plasmids in Jurkat T cells.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P65	P65	NUM	CD	NumType=Card	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	P65	P65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
10	P50	P50	NUM	CD	NumType=Card	_	_	_	_
11	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	P	p	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	through	through	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	P	P	NOUN	NN	Number=Sing	_	_	_	_
32	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
33	when	when	ADV	WRB	PronType=Int	_	_	_	_
34	expression	expression	NUM	CD	NumType=Card	_	_	_	_
35	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	P	p	NOUN	NN	Number=Sing	_	_	_	_
40	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
44	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
47	T	T	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10822
# text = In EMSAs, NF(P) binding was inhibited by the unlabeled NF-AT binding site but not by the unlabeled AP1 binding site and purified NF-AT contained an activity that bound to the P sequence.
1	In	in	ADP	IN	_	_	_	_	_
2	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	unlabeled	unlabel	ADJ	JJ	Degree=Pos	_	_	_	_
14	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	AT	at	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	unlabeled	unlabel	ADJ	JJ	Degree=Pos	_	_	_	_
24	AP1	Ap1	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	purified	purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	AT	at	ADV	RB	_	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	P	P	NOUN	NN	Number=Sing	_	_	_	_
40	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10823
# text = Both mobility shift and sequence specificity of NF-AT were similar to those of NF(P) and only a small amount of P65 was detected in NF(P) in crude nuclear extracts.
1	Both	both	DET	DT	_	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	AT	AT	PRON	WDT	PronType=Rel	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
24	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	P65	P65	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	crude	crude	ADJ	JJ	Degree=Pos	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10824
# text = These results indicate that the component(s) of NF-AT has the potential to reconstitute NF(P) whereas NF-kappa B alone cannot account for NF(P) in crude extracts.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
14	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	reconstitute	reconstitute	VERB	VB	VerbForm=Inf	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	alone	alone	ADV	RB	_	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
30	not	not	PART	RB	_	_	_	_	_
31	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	crude	crude	ADJ	JJ	Degree=Pos	_	_	_	_
39	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10825
# text = Unlike NF-AT, NF(P) does not contain AP1 as its DNA binding component.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
13	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10826
# text = Document 0030012342 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012342	0030012342	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10827
# text = Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10828
# text = The present work has studied mechanisms responsible for induction of early growth response 1 (EGR-1) gene expression during monocytic differentiation of U-937 myeloid leukemia cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	937	937	NUM	CD	NumType=Card	_	_	_	_
29	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10829
# text = Differentiation of U-937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of the serine/threonine protein kinase C, was associated with transcriptional activation of EGR-1 promoter-reporter constructs.
1	Differentiation	Differentiation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	937	937	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
38	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10830
# text = The EGR-1 promoter contains six CC(A/T)6GG (CArG) motifs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	six	six	NUM	CD	NumType=Card	_	_	_	_
8	CC	cc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	A/T	A/T	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	6GG	6gg	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CArG	CArG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10831
# text = The two 5'-most distal CArG sequences conferred TPA inducibility.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	most	most	ADV	RBS	_	_	_	_	_
7	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
8	CArG	CArG	PROPN	NNP	Number=Sing	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10832
# text = In contrast, there was little effect of TPA on EGR-1 transcription in a TPA-resistant U-937 cell variant, designated TUR.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	there	there	PRON	EX	_	_	_	_	_
5	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
20	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	937	937	NUM	CD	NumType=Card	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	variant	variant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	TUR	Tur	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10833
# text = Treatment of both U-937 and TUR cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases 1 and 2A, was associated with induction of monocytic differentiation and EGR-1 transcription through the 5'-most CArG element.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	937	937	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	TUR	Tur	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	2A	2a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	through	through	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
44	CArG	Carg	NOUN	NN	Number=Sing	_	_	_	_
45	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10834
# text = Since these findings supported the involvement of serine/threonine protein phosphorylation in the regulation of EGR-1 expression, we studied activation of the 40S ribosomal protein S6 serine/threonine kinases, pp70S6K and pp90rsk.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
4	supported	support	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	S	s	NOUN	NN	Number=Sing	_	_	_	_
29	ribosomal	ribosomal	ADJ	JJ	Degree=Pos	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	S6	S6	NUM	CD	NumType=Card	_	_	_	_
32	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
35	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	pp70S6	pp70S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	K	k	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10835
# text = Although both kinases participate in regulating cell growth, there was no detectable activation of pp70S6K during TPA- or okadaic acid-induced monocytic differentiation.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	there	there	PRON	EX	_	_	_	_	_
11	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	no	no	DET	DT	_	_	_	_	_
13	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	pp70S6	pp70S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	K	k	NUM	CD	NumType=Card	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
23	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10836
# text = Moreover, rapamycin, an inhibitor of pp70S6K activation, had no effect on induction of EGR-1 expression.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	pp70S6	pp70S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	K	k	NUM	CD	NumType=Card	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10837
# text = In contrast, analysis of pp90rsk activity by phosphorylation of a peptide derived from S6 protein demonstrated stimulation of this kinase in TPA-treated U-937, and not TUR, cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	S6	S6	NUM	CD	NumType=Card	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	TUR	Tur	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10838
# text = Okadaic acid treatment of both cell types was associated with activation of pp90rsk.
1	Okadaic	Okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	types	type	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10839
# text = Document 0030012356 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012356	0030012356	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10840
# text = Human immunodeficiency virus type 1
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 10841
# text = Tat upregulates interleukin-2 secretion in activated T cells.
1	Tat	Tat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	upregulates	upregulate	X	GW	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10842
# text = Dysregulation of cytokines secreted by T cells may play an important role in the pathogenesis of AIDS.
1	Dysregulation	Dysregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
4	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10843
# text = To investigate the effects of human immunodeficiency virus type 1 (HIV-1)
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 10844
# text = Tat on interleukin-2 (IL-2) expression, we used IL-2 promoter-chloramphenicol acetyltransferase constructs and IL-2-secreting Jurkat T cells as a model system.
1	Tat	Tat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
21	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
22	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	secreting	secreting	NOUN	NN	Number=Sing	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	model	model	NOUN	NN	Number=Sing	_	_	_	_
35	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10845
# text = Transient expression of HIV-1
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 10846
# text = Tat induced a five- to eightfold increase in IL-2 promoter activity in Jurkat T cells stimulated with phytohemagglutinin and phorbol myristate acetate.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	five	five	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	eightfold	eightfold	VERB	VB	VerbForm=Inf	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
24	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
25	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10847
# text = IL-2 secretion was increased more than twofold in both Jurkat T cells and primary T cells stimulated by extracellular HIV-1
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
8	than	than	ADP	IN	_	_	_	_	_
9	twofold	twofold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 10848
# text = Tat protein.
1	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10849
# text = Analysis of mRNA suggested that
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
4	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_

# sent_id = 10850
# text = Tat exerts its effect on IL-2 primarily at the transcriptional level.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	primarily	primarily	ADV	RB	_	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10851
# text = The NF-kappa B site at positions -206 to -195 of the IL-2 promoter was required but not sufficient for the Tat effect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	206	206	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	195	195	NUM	CD	NumType=Card	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	sufficient	sufficient	VERB	VB	VerbForm=Inf	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10852
# text = The Tat-mediated increase in IL-2 promoter activity could selectively be blocked by antisense tat or-unlike the analogous effect of human T-cell lymphotropic virus type 1 Tax-by cyclosporin A.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	selectively	selectively	ADV	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
18	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	unlike	unlike	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	type	type	NOUN	NN	Number=Sing	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	by	by	ADP	IN	_	_	_	_	_
36	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
37	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10853
# text = The observed increase in IL-2 levels might facilitate virus spread from or to T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
3	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
10	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	spread	spread	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10854
# text = Furthermore, it might contribute to the hypergammaglobulinemia or, together with other cytokines found to be dysregulated, the T-helper cell dysfunctions observed in AIDS patients.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
5	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hypergammaglobulinemia	hypergammaglobulinemia	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	together	together	ADV	RB	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	dysregulated	dysregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	dysfunctions	dysfunction	NOUN	NNS	Number=Plur	_	_	_	_
25	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
28	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10855
# text = Document 0030012358 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012358	0030012358	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10856
# text = Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes.
1	Pyrrolidine	Pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
2	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
21	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
26	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	60	60	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10857
# text = We examined the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor kappa B (NF-kappa B), on the induction of apoptosis by a variety of agents.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
7	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	potently	potently	ADV	RB	_	_	_	_	_
14	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10858
# text = Treatment of a human promyelocytic leukemia cell line, HL-60, with 10 micrograms/mL etoposide or 2 microM 1-beta-D-arabinofuranosylcytosine induced NF-kappa B activation within 1 hr and subsequently caused apoptosis within 3-4 hr.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	10	10	NUM	CD	NumType=Card	_	_	_	_
16	micrograms	microgram	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	mL	mL	ADJ	JJ	Degree=Pos	_	_	_	_
19	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
23	1-beta	1-beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	D-	D-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	arabinofuranosylcytosine	arabinofuranosylcytosine	NOUN	NN	Number=Sing	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	within	within	ADP	IN	_	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	subsequently	subsequently	ADV	RB	_	_	_	_	_
38	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	within	within	ADP	IN	_	_	_	_	_
41	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	4	4	NUM	CD	NumType=Card	_	_	_	_
44	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10859
# text = The simultaneous addition of 50-500 microM PDTC with these agents blocked NF-kappa B activation and completely abrogated both morphologically apoptotic changes and internucleosomal DNA fragmentation for up to 6 hr.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
3	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	500	500	NUM	CD	NumType=Card	_	_	_	_
8	microM	microm	NUM	CD	NumType=Card	_	_	_	_
9	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	completely	completely	ADV	RB	_	_	_	_	_
21	abrogated	abrogate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	morphologically	morphologically	ADV	RB	_	_	_	_	_
24	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
25	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	internucleosomal	internucleosomal	ADJ	JJ	Degree=Pos	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	up	up	ADV	RB	_	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	6	6	NUM	CD	NumType=Card	_	_	_	_
34	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10860
# text = However, PDTC failed to inhibit the endonuclease activity contained in the whole cell lysates.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
4	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	endonuclease	endonuclease	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10861
# text = The inhibitory effect of PDTC was also observed in etoposide- and dexamethasone-induced apoptosis in human thymocytes at a concentration of 1-10 microM.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	dexamethasone	dexamethasone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10862
# text = Since PDTC has both antioxidant and metal-ion chelating activities, we tested the effects of N-acetyl-L-cysteine (NAC) (antioxidant) or o-phenanthroline (OP) (metal-ion chelator) on the induction of apoptosis.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	PDTC	PDTC	PROPN	NNP	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	metal	metal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	ion	ion	NOUN	NN	Number=Sing	_	_	_	_
10	chelating	chelating	NOUN	NN	Number=Sing	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-L	-l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	o-phenanthroline	o-phenanthroline	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	OP	op	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	metal	metal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-ion	-ion	NOUN	NN	Number=Sing	_	_	_	_
37	chelator	chelator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10863
# text = Pretreatment of HL-60 cells or thymocytes with 100-500 microM OP for 2 hr, but not 10-60 mM
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	500	500	NUM	CD	NumType=Card	_	_	_	_
13	microM	microm	PROPN	NNP	Number=Sing	_	_	_	_
14	OP	op	PROPN	NNP	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-60	-60	NUM	CD	NumType=Card	_	_	_	_
23	mM	mm	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10864
# text = NAC, suppressed subsequent occurrence of apoptosis induced by etoposide.
1	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
5	occurrence	occurrence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	etoposide	etoposide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10865
# text = These results suggest that the activation of NF-kappa B plays an important role in the apoptotic process of human hematopoietic cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
19	process	process	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10866
# text = Document 0030012360 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012360	0030012360	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10867
# text = The development of functionally responsive T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	functionally	functionally	ADV	RB	_	_	_	_	_
5	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10868
# text = The work reviewed in this article separates T cell development into four phases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	reviewed	review	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	article	article	NOUN	NN	Number=Sing	_	_	_	_
7	separates	separate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	T	t	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	four	four	NUM	CD	NumType=Card	_	_	_	_
13	phases	phase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10869
# text = First is an expansion phase prior to TCR rearrangement, which appears to be correlated with programming of at least some response genes for inducibility.
1	First	first	ADV	RB	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
6	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	TCR	TCR	ADJ	JJR	Degree=Cmp	_	_	_	_
9	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	programming	programming	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	at	at	ADV	RB	_	_	_	_	_
20	least	least	ADV	RBS	Degree=Sup	_	_	_	_
21	some	some	DET	DT	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10870
# text = This phase can occur to some extent outside of the thymus.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	some	some	DET	DT	_	_	_	_	_
7	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
8	outside	outside	ADP	IN	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10871
# text = However, the profound T cell deficit of nude mice indicates that the thymus is by far the most potent site for inducing the expansion per se, even if other sites can induce some response acquisition.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	deficit	deficit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nude	nude	ADJ	JJ	Degree=Pos	_	_	_	_
10	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
11	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	far	far	ADV	RB	Degree=Pos	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	most	most	ADV	RBS	_	_	_	_	_
20	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	SCONJ	IN	_	_	_	_	_
23	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
26	per	per	ADP	IN	_	_	_	_	_
27	se	se	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	even	even	ADV	RB	_	_	_	_	_
30	if	if	SCONJ	IN	_	_	_	_	_
31	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
35	some	some	DET	DT	_	_	_	_	_
36	response	response	NOUN	NN	Number=Sing	_	_	_	_
37	acquisition	acquisition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10872
# text = Second is a controlled phase of TCR gene rearrangement.
1	Second	second	ADV	RB	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10873
# text = The details of the regulatory mechanism that selects particular loci for rearrangement are still not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	details	detail	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	selects	select	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
10	loci	loci	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	still	still	ADV	RB	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10874
# text = It seems that the rearrangement of the TCR gamma loci in the gamma delta lineage may not always take place at a developmental stage strictly equivalent to the rearrangement of TCR beta in the alpha beta lineage, and it is not clear just how early the two lineages diverge.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
15	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	always	always	ADV	RB	_	_	_	_	_
19	take	take	VERB	VB	VerbForm=Inf	_	_	_	_
20	place	place	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
24	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
25	strictly	strictly	ADV	RB	_	_	_	_	_
26	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
37	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	not	not	PART	RB	_	_	_	_	_
43	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
44	just	just	ADV	RB	_	_	_	_	_
45	how	how	ADV	WRB	PronType=Int	_	_	_	_
46	early	early	ADV	RB	Degree=Pos	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	two	two	NUM	CD	NumType=Card	_	_	_	_
49	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
50	diverge	diverge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10875
# text = In the TCR alpha beta lineage, however, the final gene rearrangement events are accompanied by rapid proliferation and an interruption in cellular response gene inducibility.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	final	final	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	interruption	interruption	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10876
# text = The loss of conventional responsiveness is probably caused by alterations at the level of signaling, and may be a manifestation of the physiological state that is a precondition for selection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	conventional	conventional	ADJ	JJ	Degree=Pos	_	_	_	_
5	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	probably	probably	ADV	RB	_	_	_	_	_
8	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	manifestation	manifestation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
25	state	state	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	precondition	precondition	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	selection	selection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10877
# text = Third is the complex process of selection.
1	Third	third	ADV	RB	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
5	process	process	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	selection	selection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10878
# text = Whereas peripheral T cells can undergo forms of positive selection (by antigen-driven clonal expansion) and negative selection (by abortive stimulation leading to anergy or death), neither is exactly the same phenomenon that occurs in the thymic cortex.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	undergo	undergo	VERB	VB	VerbForm=Inf	_	_	_	_
7	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	by	by	ADP	IN	_	_	_	_	_
13	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
17	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
21	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	by	by	ADP	IN	_	_	_	_	_
24	abortive	abortive	ADJ	JJ	Degree=Pos	_	_	_	_
25	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	neither	neither	CCONJ	CC	_	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	exactly	exactly	ADV	RB	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
38	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
39	that	that	PRON	WDT	PronType=Rel	_	_	_	_
40	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
44	cortex	cortex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10879
# text = Negative selection in the cortex appears to be a suicidal inversion of antigen responsiveness: instead of turning on IL-2 expression, the activated cell destroys its own chromatin.
1	Negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
2	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cortex	cortex	NOUN	NN	Number=Sing	_	_	_	_
6	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	suicidal	suicidal	ADJ	JJ	Degree=Pos	_	_	_	_
11	inversion	inversion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
14	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	instead	instead	ADV	RB	_	_	_	_	_
17	of	of	SCONJ	IN	_	_	_	_	_
18	turning	turn	VERB	VBG	VerbForm=Ger	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	destroys	destroy	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
31	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10880
# text = The genes that need to be induced for this response are not yet identified, but it is unquestionably a form of activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	need	need	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	yet	yet	ADV	RB	_	_	_	_	_
14	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	unquestionably	unquestionably	ADV	RB	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	form	form	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10881
# text = It is interesting that in humans and rats, cortical thymocytes undergoing negative selection can still induce IL-2R alpha expression and even be rescued in vitro, if exogenous IL-2 is provided.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	interesting	interesting	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	rats	rat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	cortical	cortical	ADJ	JJ	Degree=Pos	_	_	_	_
11	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	undergoing	undergoing	VERB	VBG	VerbForm=Ger	_	_	_	_
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	still	still	ADV	RB	_	_	_	_	_
17	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	even	even	ADV	RB	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	rescued	rescue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	if	if	SCONJ	IN	_	_	_	_	_
31	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
32	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10882
# text = Perhaps murine thymocytes are denied this form of rescue because they shut off IL-2R beta chain expression at an earlier stage or because they may be uncommonly Bcl-2 deficient (cf. Sentman et al., 1991; Strasser et al., 1991).
1	Perhaps	perhaps	ADV	RB	_	_	_	_	_
2	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
3	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	denied	deny	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
10	because	because	SCONJ	IN	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	shut	shut	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	off	off	ADP	RP	_	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
23	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	because	because	SCONJ	IN	_	_	_	_	_
26	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	uncommonly	uncommonly	ADV	RB	_	_	_	_	_
30	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	cf.	cf.	X	FW	_	_	_	_	_
36	Sentman	Sentman	X	GW	_	_	_	_	_
37	et	et	X	FW	_	_	_	_	_
38	al.	al.	X	FW	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	1991	1991	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	;	;	PUNCT	,	_	_	_	_	_
42	Strasser	Strasser	PROPN	NNP	Number=Sing	_	_	_	_
43	et	et	X	FW	_	_	_	_	_
44	al.	al.	X	FW	_	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	1991	1991	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10883
# text = Even so, medullary thymocytes remain at least partially susceptible to negative selection even as they continue to mature .
1	Even	even	ADV	RB	_	_	_	_	_
2	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	medullary	medullary	ADJ	JJ	Degree=Pos	_	_	_	_
5	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	partially	partially	ADV	RB	_	_	_	_	_
10	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
14	even	even	ADV	RB	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	continue	continue	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	mature	mature	VERB	VB	VerbForm=Inf	_	_	_	_
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10884
# text = Document 0030012361 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012361	0030012361	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10885
# text = LPS tolerance in monocytes/macrophages: three 3' cytosins are required in the DNA binding motif for detection of upregulated NF-kappa B p50 homodimers.
1	LPS	Lp	ADJ	JJ	Degree=Pos	_	_	_	_
2	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	cytosins	cytosin	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	upregulated	upregulate	ADJ	JJ	Degree=Pos	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	p50	p50	NUM	CD	NumType=Card	_	_	_	_
28	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10886
# text = When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	repeatedly	repeatedly	ADV	RB	_	_	_	_	_
11	then	then	ADV	RB	PronType=Dem	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	initially	initially	ADV	RB	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	very	very	ADV	RB	_	_	_	_	_
28	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	i.e.	i.e.	X	FW	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10887
# text = Tolerant cells still express the CD14 receptor and they can still be activated to mobilize NF-kappa B into nucleus.
1	Tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	still	still	ADV	RB	_	_	_	_	_
4	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	14	14	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	still	still	ADV	RB	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	mobilize	mobilize	VERB	VB	VerbForm=Inf	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10888
# text = Analysis of the binding proteins employing the -605 motif of the human TNF promoter (GGGGCTGTCCC) revealed that in tolerant cells of the human monocytic cell line Mono Mac 6 there is a predominance of p50p50 of NF-kappa B.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	employing	employ	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	605	605	NUM	CD	NumType=Card	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	GGGGCTGTCCC	GGGGCTGTCCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	_
30	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
31	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	there	there	PRON	EX	_	_	_	_	_
34	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	predominance	predominance	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	p50p50	p50p50	NUM	CD	NumType=Card	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
43	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10889
# text = We now show that a mutant motif that exchanges the terminal 3' C for a G fails to bind the p50 homodimer that is upregulated in LPS toler ant human Mono Mac 6 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
7	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	exchanges	exchange	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	_
14	C	c	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	G	g	NOUN	NN	Number=Sing	_	_	_	_
18	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
29	toler	toler	ADV	RB	_	_	_	_	_
30	ant	ant	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
33	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10890
# text = The same is true for nuclear extracts taken from the murine P388D1 macrophage cell line when tested with the -516 motif of the murine TNF promoter (GGGGGCTTTCCC).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
12	P388D1	P388d1	NOUN	NN	Number=Sing	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	tested	tested	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	516	516	NUM	CD	NumType=Card	_	_	_	_
22	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
26	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	GGGGGCTTTCCC	GGGGGCTTTCCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10891
# text = Here the wild type motif gives efficient binding of p50p50 that again is upregulated in tolerant cells whereas a mutant with a 3' G shows hardly any binding of p50p50.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
6	gives	give	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p50p50	p50p50	NUM	CD	NumType=Card	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	again	again	ADV	RB	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	'	'	PUNCT	``	_	_	_	_	_
25	G	g	NOUN	NN	Number=Sing	_	_	_	_
26	shows	show	NOUN	NNS	Number=Plur	_	_	_	_
27	hardly	hardly	ADV	RB	_	_	_	_	_
28	any	any	DET	DT	_	_	_	_	_
29	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	p50p50	p50p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10892
# text = Conversely, the murine kappa light chain enhancer motif (GGGGACTTTCCG) does not efficiently bind the nuclear p50p50 from tolerant murine P388 macrophages.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	light	light	NOUN	NN	Number=Sing	_	_	_	_
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	GGGGACTTTCCG	GGGGACTTTCCG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	efficiently	efficiently	ADV	RB	_	_	_	_	_
16	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	p50p50	p50p50	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	tolerant	tolerant	NOUN	NN	Number=Sing	_	_	_	_
22	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
23	P388	P388	NOUN	NN	Number=Sing	_	_	_	_
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10893
# text = Binding is, however, readily detected when the 3' G is replaced by a C.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	readily	readily	ADV	RB	_	_	_	_	_
7	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	``	_	_	_	_	_
12	G	g	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10894
# text = These data show that the detection of upregulated p50 homodimers in LPS tolerant cells is dependent on subtle differences in the sequence of the DNA binding motif.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	upregulated	upregulate	ADJ	JJ	Degree=Pos	_	_	_	_
9	p50	p50	NUM	CD	NumType=Card	_	_	_	_
10	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
13	tolerant	tolerant	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
19	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10895
# text = Document 0030012364 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012364	0030012364	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10896
# text = Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.
1	Cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
2	disposition	disposition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	sulphamethoxazole	sulphamethoxazole	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	hypersensitivity	hypersensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10897
# text = 1. Bioactivation of sulphamethoxazole (SMX) to chemically-reactive metabolites and subsequent protein conjugation is thought to be involved in SMX hypersensitivity.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Bioactivation	Bioactivation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	sulphamethoxazole	sulphamethoxazole	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	chemically	chemically	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
13	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	SMX	Smx	ADJ	JJ	Degree=Pos	_	_	_	_
25	hypersensitivity	hypersensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10898
# text = We have therefore examined the cellular metabolism, disposition and conjugation of SMX and its metabolites in vitro.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	disposition	disposition	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10899
# text = 2. Flow cytometry revealed binding of N-hydroxy (SMX-NHOH) and nitroso (SMX-NO) metabolites of SMX, but not of SMX itself, to the surface of viable white blood cells.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
4	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	hydroxy	hydroxy	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	NHOH	NHOH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	nitroso	nitroso	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	SMX	Smx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	NO	no	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	not	not	ADV	RB	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	_
30	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	viable	viable	ADJ	JJ	Degree=Pos	_	_	_	_
37	white	white	ADJ	JJ	Degree=Pos	_	_	_	_
38	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10900
# text = Cellular haptenation by SMX-NO was reduced by exogenous glutathione (GSH).
1	Cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	haptenation	haptenation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	NO	no	DET	DT	_	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	GSH	GSH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10901
# text = 3. SMX-NHOH and SMX-NO were rapidly reduced back to the parent compound by cysteine (CYS), GSH, human peripheral blood cells and plasma, suggesting that this is an important and ubiquitous bioinactivation mechanism.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	NHOH	NHOH	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	NO	no	INTJ	UH	_	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	rapidly	rapidly	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	back	back	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	parent	parent	NOUN	NN	Number=Sing	_	_	_	_
17	compound	compound	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CYS	CYS	INTJ	UH	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	GSH	Gsh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
28	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
41	bioinactivation	bioinactivation	NOUN	NN	Number=Sing	_	_	_	_
42	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10902
# text = 4.
1	4	4	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10903
# text = Fluorescence HPLC showed that SMX-NHOH and SMX-NO depleted CYS and GSH in buffer, and to a lesser extent, in cells and plasma.
1	Fluorescence	Fluorescence	PROPN	NNP	Number=Sing	_	_	_	_
2	HPLC	HPLC	PROPN	NNP	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	NHOH	NHOH	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	NO	no	DET	DT	_	_	_	_	_
12	depleted	deplete	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	CYS	CYS	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	GSH	GSH	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	buffer	buffer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
23	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10904
# text = 5.
1	5	5	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10905
# text = Neutrophil apoptosis and inhibition of neutrophil function were induced at lower concentrations of SMX-NHOH and SMX-NO than those inducing loss of membrane viability, with SMX having no effect.
1	Neutrophil	Neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
2	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
12	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	NHOH	NHOH	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	NO	no	INTJ	UH	_	_	_	_	_
21	than	than	ADP	IN	_	_	_	_	_
22	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
24	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
27	viability	viability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	with	with	SCONJ	IN	_	_	_	_	_
30	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	_
31	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
32	no	no	DET	DT	_	_	_	_	_
33	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10906
# text = Lymphocytes were significantly (P<0.05) more sensitive to the direct cytotoxic effects of SMX-NO than neutrophils.
1	Lymphocytes	Lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	significantly	significantly	ADV	RB	_	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	more	more	ADV	RBR	_	_	_	_	_
10	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytotoxic	cytotoxic	NOUN	NN	Number=Sing	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	NO	no	INTJ	UH	_	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10907
# text = 6. Partitioning of SMX-NHOH into red blood cells was significantly (P<0.05) lower than with the hydroxylamine of dapsone.
1	6	6	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Partitioning	Partitioning	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	SMX	SMX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	NHOH	NHOH	PROPN	NNP	Number=Sing	_	_	_	_
8	into	into	ADP	IN	_	_	_	_	_
9	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	hydroxylamine	hydroxylamine	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	dapsone	dapsone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10908
# text = 7. Our results suggest that the balance between oxidation of SMX to its toxic metabolites and their reduction is an important protective cellular mechanism.
1	7	7	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_
3	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	oxidation	oxidation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	SMX	Smx	PROPN	NNP	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	toxic	toxic	ADJ	JJ	Degree=Pos	_	_	_	_
16	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
23	protective	protective	ADJ	JJ	Degree=Pos	_	_	_	_
24	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10909
# text = If an imbalance exists, haptenation of the toxic metabolites to bodily proteins including the surface of viable cells can occur, and may result in drug hypersensitivity.
1	If	if	SCONJ	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	_
4	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	haptenation	haptenation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	toxic	toxic	ADJ	JJ	Degree=Pos	_	_	_	_
10	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	bodily	bodily	VERB	VB	VerbForm=Inf	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	viable	viable	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
28	hypersensitivity	hypersensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10910
# text = Document 0030012370 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012370	0030012370	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10911
# text = Induction of Mn SOD in human monocytes without inflammatory cytokine production by a mutant endotoxin.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
4	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	without	without	ADP	IN	_	_	_	_	_
9	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
15	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10912
# text = Endotoxin selectively induces monocyte
1	Endotoxin	Endotoxin	PROPN	NNP	Number=Sing	_	_	_	_
2	selectively	selectively	ADV	RB	_	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 10913
# text = Mn superoxide dismutase (SOD) without affecting levels of Cu,Zn SOD, catalase, or glutathione peroxidase.
1	Mn	Mn	ADJ	JJ	Degree=Pos	_	_	_	_
2	superoxide	superoxide	NOUN	NN	Number=Sing	_	_	_	_
3	dismutase	dismutase	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	SOD	Sod	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	without	without	SCONJ	IN	_	_	_	_	_
8	affecting	affecte	VERB	VBG	VerbForm=Ger	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Cu	Cu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Zn	Zn	PROPN	NNP	Number=Sing	_	_	_	_
14	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	glutathione	glutathione	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10914
# text = However, little is known about the structure-activity relationship and the mechanism by which endotoxin induces Mn SOD.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	about	about	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	endotoxin	endotoxin	ADP	IN	_	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
20	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10915
# text = In this study we demonstrated that a mutant Escherichia coli endotoxin lacking myristoyl fatty acid at the 3' R-3-hydroxymyristate position of the lipid A moiety retained its full capacity to coagulate Limulus amoebocyte lysate compared with the wild-type E. coli endotoxin and markedly stimulated the activation of human monocyte nuclear factor-kappaB and the induction of Mn SOD mRNA and enzyme activity.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
9	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
10	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
11	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
12	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
13	myristoyl	myristoyl	ADJ	JJ	Degree=Pos	_	_	_	_
14	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
15	acid	acid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	_
20	R-	R-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	hydroxymyristate	hydroxymyristate	NOUN	NN	Number=Sing	_	_	_	_
24	position	position	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lipid	lipid	NOUN	NN	Number=Sing	_	_	_	_
28	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	moiety	moiety	NOUN	NN	Number=Sing	_	_	_	_
30	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
32	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
34	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	coagulate	coagulate	VERB	VB	VerbForm=Inf	_	_	_	_
37	Limulus	Limulus	PROPN	NNP	Number=Sing	_	_	_	_
38	amoebocyte	amoebocyte	NOUN	NN	Number=Sing	_	_	_	_
39	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
40	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	type	type	NOUN	NN	Number=Sing	_	_	_	_
46	E.	E.	NOUN	NN	Number=Sing	_	_	_	_
47	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
48	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	markedly	markedly	ADV	RB	_	_	_	_	_
51	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
56	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
57	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
58	factor-kappaB	factor-kappab	NOUN	NN	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
64	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
65	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
68	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10916
# text = However, in contrast to the wild-type endotoxin, it failed to induce significant production of tumor necrosis factor-alpha and macrophage inflammatory protein-1alpha by monocytes and did not induce the phosphorylation and nuclear translocation of mitogen-activated protein kinase.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
16	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10917
# text = These results suggest that 1) lipid A myristoyl fatty acid, although it is important for the induction of inflammatory cytokine production by human monocytes, is not necessary for the induction of Mn SOD, 2) endotoxin-mediated induction of Mn SOD and inflammatory cytokines are regulated, at least in part, through different signal transduction pathways, and 3) failure of the mutant endotoxin to induce tumor necrosis factor-alpha production is, at least in part, due to its inability to activate mitogen-activated protein kinase.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	1	1	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	lipid	lipid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	myristoyl	myristoyl	ADJ	JJ	Degree=Pos	_	_	_	_
10	fatty	fatty	NOUN	NN	Number=Sing	_	_	_	_
11	acid	acid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	although	although	SCONJ	IN	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
36	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	2	2	X	LS	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	endotoxin-	endotoxin-	SYM	NFP	_	_	_	_	SpaceAfter=No
41	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	_
45	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
48	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
49	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	at	at	ADV	RB	_	_	_	_	_
53	least	least	ADV	RBS	Degree=Sup	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	through	through	ADP	IN	_	_	_	_	_
58	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
59	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
60	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
61	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	3	3	X	LS	_	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
69	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
70	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
71	to	to	PART	TO	_	_	_	_	_
72	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
73	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
74	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
75	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
77	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
78	production	production	NOUN	NN	Number=Sing	_	_	_	_
79	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
80	,	,	PUNCT	,	_	_	_	_	_
81	at	at	ADV	RB	_	_	_	_	_
82	least	least	ADV	RBS	Degree=Sup	_	_	_	_
83	in	in	ADP	IN	_	_	_	_	_
84	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	due	due	ADP	IN	_	_	_	_	_
87	to	to	ADP	IN	_	_	_	_	_
88	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
89	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
90	to	to	PART	TO	_	_	_	_	_
91	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
92	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
93	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
94	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
95	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
96	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
97	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10918
# text = Document 0030012371 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012371	0030012371	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10919
# text = Of the GATA-binding proteins, only GATA-4 selectively regulates the human IL-5 gene promoter in IL-5 producing cells which express multiple GATA-binding proteins.
1	Of	of	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	only	only	ADV	RB	_	_	_	_	_
9	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	selectively	selectively	ADV	RB	_	_	_	_	_
13	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	producing	producing	VERB	VBG	VerbForm=Ger	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
30	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10920
# text = Interleukin-5 (IL-5) is produced by T lymphocytes and known to support B cell growth and eosinophilic differentiation of the progenitor cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	support	support	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
20	growth	growth	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	progenitor	progenitor	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10921
# text = Using ATL-16T cells which express IL-5 mRNA, we have identified a region, within the human IL-5 gene promoter, that regulates IL-5 gene transcription.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	ATL	Atl	ADV	RB	_	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	16T	16t	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	5	5	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
29	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	5	5	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10922
# text = This cis-acting sequence contains the core binding motif, (A/T)GATA(A/G), for GATA-binding family proteins and thus suggests the involvement of these family members.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	A/T	Aetween	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	A/G	A/G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	thus	thus	ADV	RB	_	_	_	_	_
28	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	_
34	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10923
# text = In this report, we describe the cloning of human GATA-4 (hGATA-4) and show that hGATA-4 selectively interacts with the -70 GATA site within the IL-5 proximal promoter region.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	hGATA	hGATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	selectively	selectively	ADV	RB	_	_	_	_	_
26	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	70	70	NUM	CD	NumType=Card	_	_	_	_
31	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	_
33	within	within	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	5	5	NUM	CD	NumType=Card	_	_	_	_
38	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
40	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10924
# text = By promoter deletion and mutation analyses, we established this region as a positive regulatory element.
1	By	by	ADP	IN	_	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	established	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10925
# text = Cotransfection experiments revealed that both hGATA-4 and PMA/A23187 stimulation are necessary for the IL-5 promoter activation.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	A23187	A23187	NUM	CD	NumType=Card	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	5	5	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10926
# text = The requirement of another regulatory element called CLE0, which lies downstream of the -70 GATA site, was also demonstrated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	another	another	DET	DT	_	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	-70	-70	NUM	CD	NumType=Card	_	_	_	_
16	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10927
# text = ATL-16T cells express mRNA of three GATA-binding proteins, hGATA-2, hGATA-3 and hGATA-4, and each of them has a potential to bind to the consensus (A/T)GATA(G/ A) motif.
1	ATL	Atl	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	16T	16t	ADJ	JJS	Degree=Sup	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	hGATA	hGATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	hGATA	hGATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	each	each	DET	DT	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
30	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	A/T	A/T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	G/	G/	X	ADD	_	_	_	_	_
44	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10928
# text = However, using ATL-16T nuclear extract, we demonstrated that GATA-4 is the only GATA-binding protein that forms specific DNA-protein complex with the -70 GATA site.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	16T	16T	PROPN	NNP	Number=Sing	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	extract	extract	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
19	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	forms	form	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	70	70	NUM	CD	NumType=Card	_	_	_	_
34	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10929
# text = The electrophoretic mobility shift assay with extracts of COS cells expressing GATA-binding proteins showed that GATA-4 has the highest binding affinity to the -70 GATA site among the three GATA-binding proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	COS	Cos	NOUN	NN	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
12	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	70	70	NUM	CD	NumType=Card	_	_	_	_
30	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	among	among	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	three	three	NUM	CD	NumType=Card	_	_	_	_
35	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10930
# text = When the transactivation ability was compared among the three, GATA-4 showed the highest activity.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	among	among	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10931
# text = These results demonstrate the selective role of GATA-4 in the transcriptional regulation of the IL-5 gene in a circumstance where multiple members of the GATA-binding proteins are expressed.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	circumstance	circumstance	NOUN	NN	Number=Sing	_	_	_	_
24	where	where	ADV	WRB	PronType=Rel	_	_	_	_
25	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10932
# text = Document 0030012376 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012376	0030012376	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10933
# text = Transcriptional and posttranscriptional regulation of erythroid gene expression in anthracycline-induced differentiation of human erythroleukemic cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	anthracycline	anthracycline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	erythroleukemic	erythroleukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10934
# text = Aclacinomycin (ACLA) and doxorubicin (DOX) were used at subtoxic concentrations to induce erythroid differentiation in the human leukemic cell line K562.
1	Aclacinomycin	Aclacinomycin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	ACLA	ACLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	doxorubicin	doxorubicin	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	DOX	DOX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	subtoxic	subtoxic	ADJ	JJ	Degree=Pos	_	_	_	_
14	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	_
25	K562	k562	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10935
# text = Cell hemoglobinization was accompanied by the increased expression of genes encoding gamma-globin and porphobilinogen deaminase (PBGD), an enzyme of heme synthesis.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	hemoglobinization	hemoglobinization	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	porphobilinogen	porphobilinogen	NOUN	NN	Number=Sing	_	_	_	_
17	deaminase	deaminase	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PBGD	pBGd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	heme	heme	ADJ	JJ	Degree=Pos	_	_	_	_
26	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10936
# text = By using run-on assays, ACLA was shown to induce an enhancement of the transcription of erythroid genes, including gamma-globin, PBGD, erythropoietin receptor, and GATA-1 transcription factor.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	on	on	ADP	IN	_	_	_	_	_
6	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	ACLA	ACLA	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	PBGD	pBGd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10937
# text = In contrast, in DOX-treated cells, the transcription rate of these genes was unchanged in comparison with control cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	DOX	DOX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	unchanged	unchange	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	control	control	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10938
# text = In addition, inhibition of mRNA synthesis with actinomycin D indicated that DOX induced an increased stability of PBGD and GATA-1 mRNAs, whereas ACLA did not affect the half-lives of these mRNAs.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
7	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	actinomycin	actinomycin	PROPN	NNP	Number=Sing	_	_	_	_
10	D	D	PROPN	NNP	Number=Sing	_	_	_	_
11	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	DOX	DOX	PROPN	NNP	Number=Sing	_	_	_	_
14	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	PBGD	PBGD	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	ACLA	ACLA	PROPN	NNP	Number=Sing	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	lives	life	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10939
# text = Because the increase in erythroid mRNA steady-state level in anthracycline-treated cells was inhibited by cycloheximide, this suggests that transcriptional activation in ACLA-treated cells and mRNA stabilization in DOX-treated cells were dependent on de novo protein synthesis.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	erythroid	erythroid	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
7	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	state	state	NOUN	NN	Number=Sing	_	_	_	_
10	level	level	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	anthracycline	anthracycline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	ACLA	ACLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	treated	treated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
33	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	DOX	DOX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
41	on	on	ADP	IN	_	_	_	_	_
42	de	de	X	FW	Foreign=Yes	_	_	_	_
43	novo	novo	ADJ	JJ	Degree=Pos	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10940
# text = Finally, GATA-1 protein level was shown to be increased in ACLA-treated but not in DOX-treated cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	ACLA	ACLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	DOX	DOX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10941
# text = These two anthracyclines, although closely related in their structures, appeared to act as differentiation inducers by distinct mechanisms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	anthracyclines	anthracycline	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	although	although	SCONJ	IN	_	_	_	_	_
6	closely	closely	ADV	RB	_	_	_	_	_
7	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	structures	structure	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10942
# text = Indeed, erythroid gene expression was demonstrated to be regulated transcriptionally by ACLA and mainly posttranscriptionally by DOX.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ACLA	ACLA	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	mainly	mainly	ADV	RB	_	_	_	_	_
16	posttranscriptionally	posttranscriptionally	ADV	RB	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	DOX	DOX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10943
# text = Document 0030012381 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012381	0030012381	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10944
# text = Expression of erythroid-specific genes in megakaryoblastic disorders.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
9	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10945
# text = Currently available data indicate that erythroid and megakaryocytic differentiation pathways are closely related to each other, and there may exist progenitor cells common to those two lineages may exist.
1	Currently	currently	ADV	RB	_	_	_	_	_
2	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	closely	closely	ADV	RB	_	_	_	_	_
13	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	each	each	DET	DT	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	there	there	PRON	EX	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	_
22	progenitor	progenitor	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	two	two	NUM	CD	NumType=Card	_	_	_	_
28	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10946
# text = Acute megakaryoblastic leukemia (AML-M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	AML	aml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	M7	M7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
11	myeloproliferative	myeloproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Down	Down	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	's	's	PART	POS	_	_	_	_	_
16	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
24	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
27	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10947
# text = These blast cells express lineage-specific transcription factors such as GATA-1 common to these lineages and frequently express erythroid-specific mRNAs such as gamma-globin and erythroid delta-aminolevulinate synthase (ALAS-E), indicating that most of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	common	common	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	frequently	frequently	ADV	RB	_	_	_	_	_
21	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
33	delta-	delta-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	aminolevulinate	aminolevulinate	ADJ	JJ	Degree=Pos	_	_	_	_
35	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	ALAS	Alas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	E	e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
43	that	that	SCONJ	IN	_	_	_	_	_
44	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	M7	M7	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
52	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
53	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
54	erythroid	erythroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	and	and	CCONJ	CC	_	_	_	_	_
56	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
57	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10948
# text = These results suggest that blasts in M7 and TMD may correspond to progenitors of both erythroid and megakaryocytic lineages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	M7	M7	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	correspond	correspond	VERB	VB	VerbForm=Inf	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10949
# text = Document 0030012383 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012383	0030012383	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10950
# text = Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation.
1	Replication	Replication	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	control	control	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10951
# text = Tumor necrosis factor (TNF)-alpha controls T-cell activation and is a major inducer of human immunodeficiency virus (HIV)-1 replication in chronically infected cells.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
10	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	chronically	chronically	ADV	RB	_	_	_	_	_
30	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10952
# text = Therefore, we have investigated its role in primary cultures of HIV-infected human T lymphocytes by using neutralizing anti-TNF-alpha antibodies or TNF-alpha.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
7	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
20	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_
21	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10953
# text = Primary resting
1	Primary	primary	X	GW	_	_	_	_	_
2	resting	resting	X	ADD	_	_	_	_	_

# sent_id = 10954
# text = T lymphocytes produced TNF-alpha and supported HIV replication after T-cell receptor activation.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	supported	support	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10955
# text = Addition of neutralizing anti-TNF-alpha antibodies drastically reduced p24 antigen release and prevented CD4+ cell depletion associated with infection.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	SCONJ	IN	_	_	_	_	_
3	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
4	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
8	drastically	drastically	ADV	RB	_	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	p24	p24	NUM	CD	NumType=Card	_	_	_	_
11	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
12	release	release	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10956
# text = Anti-TNF-alpha also prevented nuclear factor-kappa B (NF-kappa B) activation, and a good correlation between this inhibition and inhibition of HIV replication was observed.
1	Anti-TNF	Anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	good	good	ADJ	JJ	Degree=Pos	_	_	_	_
22	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10957
# text = Moreover, supplementing the cultures with high doses of IL-2 reverted anti-TNF-alpha inhibition of cell proliferation but did not affect the inhibition of HIV p24 antigen release or NF-kappa B activation in the same cultures.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	supplementing	supplement	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	reverted	revert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
29	p24	p24	NUM	CD	NumType=Card	_	_	_	_
30	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
31	release	release	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
41	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10958
# text = Moreover, anti-TNF-alpha inhibited HIV-1 long terminal repeat (LTR)-driven transcription of a reporter gene in primary T cells in response to activation, either in the presence or the absence of HIV-1 Tat.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	anti-TNF	anti-tnf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	alpha	alpha	ADV	RB	_	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	either	either	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10959
# text = Our results support an important role for autocrine TNF-alpha secretion in controlling HIV replication in primary T cells because of its ability to maintain NF-kappa B elevated in the nucleus of T cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	autocrine	autocrine	NOUN	NN	Number=Sing	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	because	because	ADP	IN	_	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10960
# text = Document 0030012384 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012384	0030012384	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10961
# text = A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
25	assignment	assignment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10962
# text = Lipopolysaccharide (LPS) is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor alpha (TNF-alpha) and other inflammatory mediators.
1	Lipopolysaccharide	Lipopolysaccharide	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
8	stimulator	stimulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
15	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10963
# text = Given the deleterious effects to the host of TNF-alpha, it has been postulated that TNF-alpha gene expression must be tightly regulated.
1	Given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	deleterious	deleterious	ADJ	JJ	Degree=Pos	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	host	host	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	tightly	tightly	ADV	RB	_	_	_	_	_
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10964
# text = The nature of the nuclear factor(s) that control TNF-alpha gene transcription in humans remains obscure, although NF-kappaB has been suggested.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	control	control	NOUN	NN	Number=Sing	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
19	remains	remains	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	obscure	obscure	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	although	although	SCONJ	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10965
# text = Our previous studies pertaining to macrophage response to LPS identified a novel DNA-binding domain located from -550 to -487 in the human TNF-alpha promoter that contains transcriptional activity, but lacks any known NF-kappaB-binding sites.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	pertaining	pertai	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	macrophage	macrophage	VERB	VB	VerbForm=Inf	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
10	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
17	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	550	550	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	487	487	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	any	any	DET	DT	_	_	_	_	_
39	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappaB-	kappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10966
# text = We have used this DNA fragment to isolate and purify a 60-kDa protein binding to this fragment and obtained its amino-terminal sequence, which was used to design degenerate probes to screen a cDNA library from THP-1 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	purify	purify	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	design	design	VERB	VB	VerbForm=Inf	_	_	_	_
33	degenerate	degenerate	ADJ	JJ	Degree=Pos	_	_	_	_
34	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	screen	screen	NOUN	NN	Number=Sing	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
39	library	library	NOUN	NN	Number=Sing	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10967
# text = A novel cDNA clone (1.8 kb) was isolated and fully sequenced.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
4	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	1.8	1.8	NUM	CD	NumType=Card	_	_	_	_
7	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	fully	fully	ADV	RB	_	_	_	_	_
13	sequenced	sequence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10968
# text = Characterization of this cDNA clone revealed that its induction was dependent on LPS activation of THP-1 cells; hence, the name LPS-induced TNF-alpha factor (LITAF).
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	clone	clone	PRON	NN	Number=Sing	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	name	name	NOUN	NN	Number=Sing	_	_	_	_
25	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10969
# text = Inhibition of LITAF mRNA expression in THP-1 cells resulted in a reduction of TNF-alpha transcripts.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10970
# text = In addition, high level of expression of LITAF mRNA was observed predominantly in the placenta, peripheral blood leukocytes, lymph nodes, and the spleen.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	level	level	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	predominantly	predominantly	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	placenta	placenta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
23	nodes	node	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10971
# text = Finally, chromosomal localization using fluorescence in situ hybridization revealed that LITAF mapped to chromosome 16p12-16p13.3.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
4	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
9	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	_
13	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	chromosome	chromosome	VERB	VB	VerbForm=Inf	_	_	_	_
16	16p12-16p13.3	16p12-16p13.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10972
# text = Together, these findings suggest that LITAF plays an important role in the activation of the human TNF-alpha gene and proposes a new mechanism to control TNF-alpha gene expression.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	LITAF	LITAF	PROPN	NNP	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	proposes	propose	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
29	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10973
# text = Document 0030012388 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012388	0030012388	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10974
# text = BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.
1	BCL	Bcl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	POZ	Poz	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10975
# text = Approximately 40% of diffuse large cell lymphoma are associated with chromosomal translocations that deregulate the expression of the BCL6 gene by juxtaposing heterologous promoters to the BCL-6 coding domain.
1	Approximately	approximately	ADV	RB	_	_	_	_	_
2	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	%	%	SYM	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	diffuse	diffuse	ADJ	JJ	Degree=Pos	_	_	_	_
6	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	chromosomal	chromosomal	NOUN	NN	Number=Sing	_	_	_	_
13	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	deregulate	deregulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	juxtaposing	juxtapose	VERB	VBG	VerbForm=Ger	_	_	_	_
24	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
25	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	6	6	NUM	CD	NumType=Card	_	_	_	_
31	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10976
# text = The BCL6 gene encodes a 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain, suggesting that it may function as a transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	six	six	NUM	CD	NumType=Card	_	_	_	_
12	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
14	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	POZ	Poz	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10977
# text = By using a DNA sequence selected for its ability to bind recombinant BCL-6 in vitro, we show here that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
12	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
13	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	here	here	ADV	RB	PronType=Dem	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	6	6	NUM	CD	NumType=Card	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10978
# text = In transient transfectin experiments, BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.
1	In	in	ADP	IN	_	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfectin	transfectin	NOUN	NN	Number=Sing	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
12	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	target	target	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	upon	upon	ADP	IN	_	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
34	N-	N-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
36	half	half	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10979
# text = We demonstrate that this part of the BCL6 molecule contains an autonomous transrepressor domain and that two noncontiguous regions, including the POZ motif, mediate maximum transrepressive activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	part	part	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
10	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	autonomous	autonomous	ADJ	JJ	Degree=Pos	_	_	_	_
13	transrepressor	transrepressor	NOUN	NN	Number=Sing	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	noncontiguous	noncontiguous	ADJ	JJ	Degree=Pos	_	_	_	_
19	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	POZ	POZ	NOUN	NN	Number=Sing	_	_	_	_
24	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
27	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
28	transrepressive	transrepressive	ADJ	JJ	Degree=Pos	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10980
# text = These results indicate that the BCL-6 protein can function as a sequence-specific transcriptional repressor and have implications for the role of BCL6 in normal lymphoid development and lymphomagenesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	BCL	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	role	role	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	BCL6	BCL6	NUM	CD	NumType=Card	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
30	development	development	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	lymphomagenesis	lymphomagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10981
# text = Document 0030012390 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012390	0030012390	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10982
# text = Expression of c-fos and c-jun proteins and AP-1 binding activity during cell cycle progression of
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
19	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_

# sent_id = 10983
# text = HL60 cells and phytohemagglutinin-stimulated lymphocytes.
1	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10984
# text = The protein products of the c-fos (p62c-fos) and c-jun (p39c-jun) genes are members of the AP-1 transcription factor family and are thought to play important roles in the regulation of gene expression during the cell cycle.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	products	product	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	p62c	p62c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p39c	p39c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	members	member	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	family	family	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
37	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
38	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
45	during	during	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10985
# text = Most studies on the expression of these proteins in relation to the cell cycle have been performed at the mRNA level, and therefore do not give direct information about the presence of the proteins during the cell cycle.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	therefore	therefore	ADV	RB	_	_	_	_	_
25	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	give	give	VERB	VB	VerbForm=Inf	_	_	_	_
28	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
29	information	information	NOUN	NN	Number=Sing	_	_	_	_
30	about	about	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
36	during	during	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10986
# text = We have used Western blotting to investigate the presence of these proteins during the cell cycles of two different cellular systems: a continuously growing myeloid leukemic cell line, HL60, and normal cells stimulated into cycle, phyto- hemagglutinin (PHA)-stimulated normal human peripheral blood lymphocytes (PBL).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
5	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	cycles	cycle	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	:	:	PUNCT	:	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	continuously	continuously	NOUN	NN	Number=Sing	_	_	_	_
25	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
27	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	HL60	HL60	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	into	into	ADP	IN	_	_	_	_	_
38	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	phyto	phyto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	_
42	hemagglutinin	hemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
49	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
50	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
51	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
52	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	PBL	PBL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10987
# text = The binding activity of transcription factor AP-1, which consists of dimers of Fos and Jun family proteins, was also studied using a gel shift assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
28	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
29	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10988
# text = We found nuclear p62c-fos, p39c-jun, and AP-1 binding activity throughout the cell cycle both in HL60 cells and in PHA-stimulated PBL, and we postulate that these proteins are required throughout the cell cycle and not transiently in the G0 to G1 transition as previous mRNA studies have indicated.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	p62c	p62c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	p39c	p39c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	throughout	throughout	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
35	postulate	postulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	throughout	throughout	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	not	not	ADV	RB	_	_	_	_	_
47	transiently	transiently	ADV	RB	_	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	G0	G0	PROPN	NNP	Number=Sing	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	G1	G1	NUM	CD	NumType=Card	_	_	_	_
53	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
54	as	as	ADP	IN	_	_	_	_	_
55	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
56	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
57	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
58	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
59	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10989
# text = We demonstrated an uncoupling of AP-1 binding activity from p62c-fos, and p39c-jun AP-1 activity was expressed more strongly in the G1- and G2/M-phase enriched samples than in the S-phase enriched samples of HL60 cells, while levels of nuclear p62c-fos and p39c-jun were constant.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	uncoupling	uncoupling	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	p62c	p62c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	p39c	p39c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	more	more	ADV	RBR	_	_	_	_	_
27	strongly	strongly	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	G1	g1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	G2/	g2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	M-	M-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
36	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
38	than	than	ADP	IN	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	S-	s-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
43	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	HL60	HL60	PROPN	NNP	Number=Sing	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	while	while	SCONJ	IN	_	_	_	_	_
50	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
53	p62c	p62c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	p39c	p39c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
60	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
61	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10990
# text = Nuclei of unstimulated PBL from different donors expressed p62c-fos and p39c-jun, but AP-1 was not detected in the majority of samples.
1	Nuclei	Nuclei	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
4	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
7	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	p62c	p62c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	p39c	p39c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10991
# text = Following PHA stimulation of PBL, the increase in AP-1 activity was delayed with respect to the augmentation of p39c-jun expression.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	PHA	PHa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	delayed	delay	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	augmentation	augmentation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p39c	p39c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10992
# text = We also observed that cytoplasmic p62c-fos and p39c-jun were present in HL60 cells and PHA-stimulated PBL.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
6	p62c	p62c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	p39c	p39c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10993
# text = However, no cytoplasmic p62c-fos was detected in unstimulated PBL, although in some cases cytoplasmic p39c-jun was detected, suggesting that subcellular compartmentalization of these proteinsmay occur under certain circumstances.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
5	p62c	p62c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
12	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	although	although	SCONJ	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	some	some	DET	DT	_	_	_	_	_
17	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
18	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
19	p39c	p39c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	subcellular	subcellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	compartmentalization	compartmentalization	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
31	proteinsmay	proteinsmay	AUX	MD	VerbForm=Fin	_	_	_	_
32	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
33	under	under	ADP	IN	_	_	_	_	_
34	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
35	circumstances	circumstance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 10994
# text = Document 0030012393 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012393	0030012393	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 10995
# text = Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
5	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HePTP	HePTP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 10996
# text = Activation of T lymphocytes to produce cytokines is regulated by the counterbalance of protein-tyrosine kinases and protein-tyrosine phosphatases, many of which have a high degree of substrate specificity because of physical association with their targets.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	counterbalance	counterbalance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
28	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	substrate	substrate	ADJ	JJ	Degree=Pos	_	_	_	_
31	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
32	because	because	ADP	IN	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
35	association	association	NOUN	NN	Number=Sing	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10997
# text = Overexpression of hematopoietic protein-tyrosine phosphatase (HePTP) results in suppression of T lymphocyte activation as measured by T cell antigen receptor-induced activation of transcription factors binding to the 5' promoter of the interleukin-2 gene.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein-	protein-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HePTP	Heptp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
22	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	'	's	PUNCT	``	_	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10998
# text = Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen-activated protein (MAP) kinases Erk1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells.
1	Efforts	effort	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	pinpoint	pinpoint	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	action	action	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HePTP	Heptp	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
17	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	HePTP	HePTP	PROPN	NNP	Number=Sing	_	_	_	_
20	acts	acts	PROPN	NNPS	Number=Plur	_	_	_	_
21	directly	directly	ADV	RB	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	MAP	map	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
32	Erk1	Erk1	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	consequently	consequently	ADV	RB	_	_	_	_	_
37	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
44	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
48	T	t	PROPN	NNP	Number=Sing	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10999
# text = In contrast, HePTP had no effects on N-terminal c-Jun kinase or on events upstream of the MAP kinases.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	HePTP	HePTP	PROPN	NNP	Number=Sing	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	events	event	NOUN	NNS	Number=Plur	_	_	_	_
18	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
22	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11000
# text = The specificity of HePTP correlated with its physical association through its noncatalytic N terminus with Erk and another MAP kinase, p38, but not Jnk or other proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HePTP	HePTP	PROPN	NNP	Number=Sing	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
9	association	association	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	noncatalytic	noncatalytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	N	n	PROPN	NNP	Number=Sing	_	_	_	_
14	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	Erk	Erk	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	another	another	DET	DT	_	_	_	_	_
19	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	p38	p38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	Jnk	Jnk	PROPN	NNP	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11001
# text = We propose that HePTP plays a negative role in antigen receptor signaling by specifically regulating MAP kinases in the cytosol and at early time points of T cell activation before the activation-induced expression of nuclear dual-specific MAP kinase phosphatases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HePTP	HePTP	PROPN	NNP	Number=Sing	_	_	_	_
5	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	specifically	specifically	ADV	RB	_	_	_	_	_
15	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	_
25	points	point	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	before	before	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
41	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
42	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
43	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11002
# text = Document 0030012394 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012394	0030012394	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11003
# text = Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
10	molecule/CD69	molecule/cd69	NOUN	NN	Number=Sing	_	_	_	_
11	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11004
# text = The induction of the AP-1 transcription factor has been ascribed to the early events leading to T cell differentiation and activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	ascribed	ascribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	events	event	NOUN	NNS	Number=Plur	_	_	_	_
17	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11005
# text = We have studied the regulation of AP-1 activity in human peripheral blood T lymphocytes stimulated through the activation inducer molecule (AIM)/CD69 activation pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
22	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	AIM	aim	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	/CD69	/CD69	NUM	CD	NumType=Card	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11006
# text = Phorbol esters are required to induce AIM/CD69 cell-surface expression as well as for triggering the proliferation of T cells in conjunction with anti-AIM mAb.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
7	AIM/CD69	AIM/CD69	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	for	for	SCONJ	IN	_	_	_	_	_
16	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
26	-AIM	-AIM	PROPN	NNP	Number=Sing	_	_	_	_
27	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11007
# text = Mobility shift assays showed that addition of anti-AIM mAb to PMA-treated T lymphocytes markedly enhanced the binding activity of AP-1 to its cognate sequence, the phorbol ester response element.
1	Mobility	Mobility	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	ADV	RB	_	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
9	-AIM	-AIM	PROPN	NNP	Number=Sing	_	_	_	_
10	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	markedly	markedly	ADV	RB	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	cognate	cognate	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
33	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11008
# text = In contrast, anti-AIM mAb did not induce any change in the binding activity of NF-kappa B, a transcription factor whose activity is also regulated by protein kinase C.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
5	-AIM	-AIM	PROPN	NNP	Number=Sing	_	_	_	_
6	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	any	any	DET	DT	_	_	_	_	_
11	change	change	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11009
# text = The increase in AP-1-binding activity was accompanied by the marked stimulation of the transcription of c-fos but not that of c-jun.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11010
# text = Blockade of the DNA-binding complexes with an anti-Fos mAb demonstrated a direct participation of c-Fos in the AP-1 complexes induced by anti-AIM mAb.
1	Blockade	Blockade	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
11	-Fos	-Fos	PROPN	NNP	Number=Sing	_	_	_	_
12	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
13	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
16	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	AIM	aim	PROPN	NNP	Number=Sing	_	_	_	_
32	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11011
# text = Most of the AP-1 activity could be eliminated when the anti-AIM mAb was added to the culture medium in the presence of cycloheximide, suggesting that de novo protein synthesis is crucial for the induction of AP-1-binding activity.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	eliminated	eliminate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	when	when	ADV	WRB	PronType=Int	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
14	-AIM	-AIM	PROPN	NNP	Number=Sing	_	_	_	_
15	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
21	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	de	de	PROPN	NNP	Number=Sing	_	_	_	_
31	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
45	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11012
# text = These data provide the evidence that activation of human peripheral blood T cells through the AIM activation pathway regulate the activity of AP-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	AIM	aim	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
19	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11013
# text = Therefore, this pathway appears as a crucial step in the initiation of early T cell activation events.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
5	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	step	step	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11014
# text = Document 0030012399 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012399	0030012399	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11015
# text = A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	CTL	CTL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
22	perforin	perforin	ADP	IN	_	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11016
# text = This study was designed to determine the potential cis-elements involved in transcriptional regulation of the mouse perforin gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
19	perforin	perforin	ADP	IN	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11017
# text = DNase I hypersensitive site (DHS) mapping revealed that the perforin locus contained six DHS within 7.0 kb of the 5' upstream sequence (-7.0 kb) and two DHS in intron 2.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	DHS	DHS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
9	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	perforin	perforin	NOUN	NN	Number=Sing	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
14	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	six	six	NUM	CD	NumType=Card	_	_	_	_
16	DHS	D	NOUN	NNS	Number=Plur	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	7.0	7.0	NUM	CD	NumType=Card	_	_	_	_
19	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	'	'	PUNCT	``	_	_	_	_	_
24	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
25	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	7.0	7.0	NUM	CD	NumType=Card	_	_	_	_
29	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	two	two	NUM	CD	NumType=Card	_	_	_	_
33	DHS	D	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
36	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11018
# text = The six 5' upstream and one intronic DHS were detected in only perforin-expressing lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	six	six	NUM	CD	NumType=Card	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	''	_	_	_	_	_
5	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	intronic	intronic	ADJ	JJ	Degree=Pos	_	_	_	_
9	DHS	D	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	perforin	perforin	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11019
# text = Chloramphenicol acetyltransferase (CAT) activities directed by 5' upstream promoter were detected preferentially in perforin-expressing cell lines.
1	Chloramphenicol	Chloramphenicol	PROPN	NNP	Number=Sing	_	_	_	_
2	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	preferentially	preferentially	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	perforin	perforin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11020
# text = A construct termed PFP5a containing -795 bp exhibited the highest CAT activity, and PFP9a20 containing only -73 bp also produced significantly high CAT activity in CTLL-R8 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
3	termed	term	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	PFP5	PFP5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	795	795	NUM	CD	NumType=Card	_	_	_	_
9	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
10	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
13	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	PFP9a20	PFP9a20	PROPN	NNP	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	73	73	NUM	CD	NumType=Card	_	_	_	_
22	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	R8	R8	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11021
# text = The proximal region in PFP9a20 contained two potential Sp1 binding sites (GC box and GT box) and one Ets binding site (EBS).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	PFP9a20	PFP9a20	NUM	CD	NumType=Card	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
9	Sp1	Sp1	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
14	box	box	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GT	Gt	NOUN	NN	Number=Sing	_	_	_	_
17	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11022
# text = Electrophoretic mobility shift assay showed that each of the cis-elements bound specific protein factors.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	each	each	DET	DT	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-elements	-element	NOUN	NNS	Number=Plur	_	_	_	_
12	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11023
# text = When single-point mutation was introduced to each GC box, EBS, and GT box in PFP9a20, at least 3-fold less CAT activity was observed in CTLL-R8 cells.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	point	point	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	each	each	DET	DT	_	_	_	_	_
10	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	_
11	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GT	Gt	NOUN	NN	Number=Sing	_	_	_	_
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	PFP9a20	PFP9a20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	at	at	ADV	RB	_	_	_	_	_
22	least	least	ADV	RBS	Degree=Sup	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
27	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	R8	R8	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11024
# text = To confirm the importance of the three cis-acting elements in the perforin gene expression, point mutation was introduced again to each proximal GC box, EBS, and GT box of PFP5a.
1	To	to	PART	TO	_	_	_	_	_
2	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-acting	-acting	VERB	VBG	VerbForm=Ger	_	_	_	_
10	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	perforin	perforin	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	point	point	NOUN	NN	Number=Sing	_	_	_	_
18	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	again	again	ADV	RB	_	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	each	each	DET	DT	_	_	_	_	_
24	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
25	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
26	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	GT	gt	NOUN	NN	Number=Sing	_	_	_	_
32	box	box	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	PFP5	PFP5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11025
# text = The point mutations resulted in a 2.5- to 3-fold reduction of CAT activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	point	point	NOUN	NN	Number=Sing	_	_	_	_
3	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
4	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11026
# text = The results suggest that a combination of the three proximal cis-acting elements may constitute a minimal region responsible for CTL-specific expression of perforin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-acting	-act	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	CTL	CTL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	perforin	perforin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11027
# text = Document 0030012400 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012400	0030012400	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11028
# text = Retinoic acid downmodulates erythroid differentiation and GATA1 expression in purified adult-progenitor culture.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	downmodulates	downmodulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GATA1	Gata1	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	adult	adult	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
14	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11029
# text = All-trans retinoic acid (RA) is an important morphogen in vertebrate development, a normal constituent in human adult blood and is also involved in the control of cell growth and differentiation in acute promyelocytic leukemia.
1	All	all	DET	DT	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
4	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	morphogen	morphogen	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vertebrate	vertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	constituent	constituent	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
23	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	also	also	ADV	RB	_	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
38	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11030
# text = We have examined the effects of RA on normal hematopoiesis by using early hematopoietic progenitor cells (HPC) stringently purified from adult peripheral blood.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
13	early	early	ADV	RB	Degree=Pos	_	_	_	_
14	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
15	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	stringently	stringently	ADV	RB	_	_	_	_	_
21	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11031
# text = In clonogenetic fetal calf serum-supplemented (FCS+) or -nonsupplemented (FCS-) culture treated with saturating levels of interleukin-3 (IL-3) granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin (Ep) (combined with c-kit ligand in FCS(-)-culture conditions), RA induces a dramatic dose-dependent shift from erythroid to granulomonocytic colony formation, the latter colonies being essentially represented by granulocytic clones.
1	In	in	ADP	IN	_	_	_	_	_
2	clonogenetic	clonogenetic	ADJ	JJ	Degree=Pos	_	_	_	_
3	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
4	calf	calf	NOUN	NN	Number=Sing	_	_	_	_
5	serum-	serum-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	FCS	FCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	nonsupplemented	nonsupplemented	ADJ	JJ	Degree=Pos	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	FCS	Fcs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	saturating	saturating	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
35	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	Ep	Ep	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
53	kit	kit	NOUN	NN	Number=Sing	_	_	_	_
54	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	FCS	FCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
61	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
65	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
66	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
67	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
68	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
71	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
72	from	from	ADP	IN	_	_	_	_	_
73	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
74	to	to	ADP	IN	_	_	_	_	_
75	granulomonocytic	granulomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
76	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
77	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	,	,	PUNCT	,	_	_	_	_	_
79	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
80	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
81	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
82	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
83	essentially	essentially	ADV	RB	_	_	_	_	_
84	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
85	by	by	ADP	IN	_	_	_	_	_
86	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
87	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
88	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11032
# text = This shift is apparently not caused by a recruitment phenomenon, because in FCS+ culture, the total number of colonies is not significantly modified by RA addition.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	apparently	apparently	ADV	RB	_	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
10	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	because	because	SCONJ	IN	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	FCS	FCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
29	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11033
# text = In FCS- liquid-suspension culture supplemented with saturating Ep level and low-dose IL-3/GM-CSF, adult HPC undergo unilineage erythropoietic differentiation:
1	In	in	ADP	IN	_	_	_	_	_
2	FCS	FCS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	_
4	liquid	liquid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	suspension	suspension	NOUN	NN	Number=Sing	_	_	_	_
7	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
8	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	SCONJ	IN	_	_	_	_	_
10	saturating	saturat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	Ep	Ep	PROPN	NNP	Number=Sing	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
17	IL-3/GM	IL-3/Gm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
22	HPC	Hpc	NOUN	NN	Number=Sing	_	_	_	_
23	undergo	undergo	NOUN	NN	Number=Sing	_	_	_	_
24	unilineage	unilineage	NOUN	NN	Number=Sing	_	_	_	_
25	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 11034
# text = Here again, treatment with high-dose RA induces a shift from the erythroid to granulocytic differentiation pathway.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	again	again	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
9	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11035
# text = Studies on RA time-response or pulse treatment in semisolid or liquid culture show that early RA addition is most effective, thus indicating that early but not late HPC are sensitive to its action.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
4	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	pulse	pulse	NOUN	NN	Number=Sing	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	semisolid	semisolid	ADJ	JJ	Degree=Pos	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	liquid	liquid	ADJ	JJ	Degree=Pos	_	_	_	_
14	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
15	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
18	RA	RA	NOUN	NN	Number=Sing	_	_	_	_
19	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	thus	thus	ADV	RB	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
31	HPC	Hpc	PROPN	NNPS	Number=Plur	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11036
# text = We then analyzed the expression of the master GATA1 gene, which encodes a finger transcription factor required for normal erythroid development; addition of RA to HPC stimulated into unilineage erythropoietic differentiation in liquid culture caused a virtually complete inhibition of GATA1 mRNA induction.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	then	then	ADV	RB	PronType=Dem	_	_	_	_
3	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	master	master	NOUN	NN	Number=Sing	_	_	_	_
9	GATA1	GATA1	PROPN	NNP	Number=Sing	_	_	_	_
10	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	into	into	ADP	IN	_	_	_	_	_
31	unilineage	unilineage	ADJ	JJ	Degree=Pos	_	_	_	_
32	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	liquid	liquid	ADJ	JJ	Degree=Pos	_	_	_	_
36	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
37	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	virtually	virtually	ADV	RB	_	_	_	_	_
40	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
41	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	GATA1	GATA1	PROPN	NNP	Number=Sing	_	_	_	_
44	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11037
# text = These results indicate that RA directly inhibits the erythroid differentiation program at the level of early adult HPC, and may lead to a shift from the erythroid to granulocytic differentiation pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	program	program	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	level	level	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
17	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
18	HPC	Hpc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
32	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11038
# text = This phenomenon is correlated with inhibition of GATA1 induction in the early stages of erythropoietic differentiation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GATA1	GATA1	NUM	CD	NumType=Card	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11039
# text = Document 0030012410 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012410	0030012410	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11040
# text = STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients.
1	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11041
# text = A signal transduction pathway activated by many cytokines has recently been elaborated.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	recently	recently	ADV	RB	_	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	elaborated	elaborate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11042
# text = The JAK kinases and the signal transducers and activators of transcription (STAT) factors have been found to be essential components.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
7	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11043
# text = In this report, we describe the presence of constitutively activated
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	constitutively	constitutively	ADV	RB	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 11044
# text = STAT factors in peripheral blood cells from patients with acute leukemia.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11045
# text = We used oligonucleotide probes from the beta-casein and IRF-1 gene promoters and the ISRE probe to detect STAT proteins in nuclear extracts from acute leukemia cells in bandshift assays.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
4	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	ISRE	Isre	ADJ	JJ	Degree=Pos	_	_	_	_
19	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
22	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
29	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	bandshift	bandshift	ADJ	JJ	Degree=Pos	_	_	_	_
33	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11046
# text = Specific DNA protein complex formation was observed with the probes from the beta-casein and IRF-1 gene promoters, but not with the ISRE oligonucleotide probe, when cell extracts from acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) were investigated.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
5	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ISRE	Isre	NOUN	NN	Number=Sing	_	_	_	_
28	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
29	probe	probe	ADV	RB	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	when	when	ADV	WRB	PronType=Int	_	_	_	_
32	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
36	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
37	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	acute	acute	VERB	VB	VerbForm=Inf	_	_	_	_
43	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
44	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	AML	aml	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11047
# text = We used nonradioactive oligonucleotides as competitors to show the specificity of the complex formation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	nonradioactive	nonradioactive	ADJ	JJ	Degree=Pos	_	_	_	_
4	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	competitors	competitor	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
14	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11048
# text = Specific antibodies directed against the individual STAT proteins were used in supershift experiments.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	against	against	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
13	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11049
# text = STAT5- and STAT1-related factors were detected in ALL and STAT1-, STAT3-, and STAT5-related proteins were present in nuclear cell extracts from AML.
1	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	STAT1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	ALL	all	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	AML	AML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11050
# text = Since the cells were not treated with cytokines before the nuclear proteins were extracted, we conclude that these factors are constitutively activated in vivo.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	before	before	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	constitutively	constitutively	ADV	RB	_	_	_	_	_
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11051
# text = It is likely that the constitutive activation of
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_

# sent_id = 11052
# text = STAT proteins is a part of the events of leukemogenesis.
1	STAT	Stat	PRON	WP	PronType=Int	_	_	_	_
2	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	part	part	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	leukemogenesis	leukemogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11053
# text = Document 0030012413 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012413	0030012413	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11054
# text = Glucocorticoid-induced apoptosis of lymphoid cells.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11055
# text = The induction of cell death in lymphoid cells by glucocorticoids is one of the earliest and most thoroughly studied models of apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	death	death	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	most	most	ADV	RBS	_	_	_	_	_
18	thoroughly	thoroughly	ADV	RB	_	_	_	_	_
19	studied	study	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	models	model	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11056
# text = Although the exact mechanism by which apoptosis occurs in lymphocytes is unknown many biochemical and molecular changes have been shown to occur in these cells in response to glucocorticoids.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unknown	unknown	ADV	RB	_	_	_	_	_
13	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
14	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11057
# text = The role of chromatin degradation and endonucleases in the apoptotic process has been closely studied, as well as the involvement of several oncogenes in glucocorticoid-induced cell lysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	endonucleases	endonuclease	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	process	process	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	closely	closely	ADV	RB	_	_	_	_	_
15	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	ADV	RB	_	_	_	_	_
18	well	well	ADV	RB	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11058
# text = In addition, the clinical importance of glucocorticoid-induced apoptosis in the treatment of lymphoid neoplasms has recently received increased attention.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
6	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	glucocorticoid	glucocorticoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	neoplasms	neoplasm	NOUN	NNS	Number=Plur	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	recently	recently	ADV	RB	_	_	_	_	_
20	received	receive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	attention	attention	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11059
# text = Document 0030012420 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012420	0030012420	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11060
# text = Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun.
1	Targeted	target	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11061
# text = The proto-oncogene products c-Fos and c-Jun heterodimerize through their leucine zippers to form the AP-1 transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
4	products	product	NOUN	NNS	Number=Plur	_	_	_	_
5	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
11	heterodimerize	heterodimerize	VERB	VB	VerbForm=Inf	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	leucine	leucine	NOUN	NN	Number=Sing	_	_	_	_
15	zippers	zipper	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11062
# text = The transcriptional activity of the heterodimer is regulated by signal-dependent phosphorylation and dephosphorylation events.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11063
# text = The stability of c-Fos was found to also be controlled by intracellular signal transduction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11064
# text = In transient expression and in vitro degradation experiments, the stability of c-Fos was decreased when the protein was dimerized with phosphorylated c-Jun.
1	In	in	ADP	IN	_	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
7	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	dimerized	dimerize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11065
# text = c-Jun protein isolated from phorbol ester-induced cells did not target c-Fos for degradation, which suggests that c-Fos is transiently stabilized after stimulation of cell growth.
1	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
15	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	transiently	transiently	ADV	RB	_	_	_	_	_
27	stabilized	stabilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	after	after	ADP	IN	_	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11066
# text = v-Fos protein, the retroviral counterpart of c-Fos, was not susceptible to degradation targeted by c-Jun.
1	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	retroviral	retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
7	counterpart	counterpart	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
18	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11067
# text = Document 0030012427 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012427	0030012427	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11068
# text = Functional antagonism between vitamin D3 and retinoic acid in the regulation of CD14 and CD23 expression during monocytic differentiation of U-937 cells.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
5	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
8	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	14	14	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	937	937	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11069
# text = 1,25 alpha-Dihydroxicholecalciferol (VitD3) and retinoic acid (RA) are important regulators of the proliferation and differentiation of several cell types.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	Dihydroxicholecalciferol	Dihydroxicholecalciferol	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	VitD3	VitD3	X	LS	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11070
# text = This paper describes how the expression of the monocyte-macrophage Ag, CD14, and the low affinity Fc receptor for IgE, CD23, were inversely regulated during VitD3- and RA-induced monocytic differentiation of human U-937 monoblasts.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
3	describes	describe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	how	how	ADV	WRB	PronType=Int	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	monocyte-	monocyte-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
11	Ag	ag	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
18	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
19	Fc	Fc	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	inversely	inversely	ADV	RB	_	_	_	_	_
28	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
40	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	937	937	NUM	CD	NumType=Card	_	_	_	_
43	monoblasts	monoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11071
# text = PMA induced the expression of both CD14 and CD23 mRNA and protein.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	14	14	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11072
# text = Exposure to VitD3 rapidly induced the de novo expression of CD14 mRNA and protein.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
4	rapidly	rapidly	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	de	de	PROPN	NNP	Number=Sing	_	_	_	_
8	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11073
# text = The addition of cycloheximide completely blocked the VitD3 induction of CD14 mRNA expression, indicating that the induction was dependent on ongoing protein synthesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
5	completely	completely	ADV	RB	_	_	_	_	_
6	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	VitD3	VitD3	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11074
# text = While inducing CD14 expression, VitD3 concomitantly suppressed the basal, PMA-, and RA-inducible CD23 expression in a dose-dependent manner.
1	While	while	SCONJ	IN	_	_	_	_	_
2	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
3	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	14	14	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
8	concomitantly	concomitantly	ADV	RB	_	_	_	_	_
9	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	basal	basal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11075
# text = In contrast, U-937 cells induced by RA strongly increased their expression of CD23 mRNA and protein, whereas they completely lacked detectable CD14 cell surface or mRNA expression.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	937	937	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
11	strongly	strongly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
23	completely	completely	ADV	RB	_	_	_	_	_
24	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
26	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	14	14	NUM	CD	NumType=Card	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11076
# text = Furthermore, the VitD3- and the PMA-induced CD14 expression was inhibited as a temporal consequence of the RA-induced differentiation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	VitD3	VitD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
19	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11077
# text = The results suggest that there exists a functional antagonism between VitD3 and RA that may have important implications for the regulation of certain immune and inflammatory responses through their inverse effects on CD14 and CD23 gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	there	there	PRON	EX	_	_	_	_	_
6	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	antagonism	antagonism	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
24	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	inverse	inverse	NOUN	NN	Number=Sing	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	14	14	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11078
# text = Document 0030012433 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012433	0030012433	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11079
# text = Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
10	nephropathy	nephropathy	ADJ	JJ	Degree=Pos	_	_	_	_
11	show	show	NOUN	NN	Number=Sing	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11080
# text = Increased oxidative stress and subsequent activation of the transcription factor NF-kappaB has been linked to the development of late diabetic complications.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
3	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
22	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
23	complications	complication	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11081
# text = To determine whether oxidative stress dependent NF-kappaB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobility Shift Assay based semiquantitative detection system which enabled us to determine NF-kappaB activation in ex vivo isolated peripheral blood mononuclear cells.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
5	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
17	nephropathy	nephropathy	NOUN	NN	Number=Sing	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	Electrophoretic	Electrophoretic	PROPN	NNP	Number=Sing	_	_	_	_
22	Mobility	Mobility	NOUN	NN	Number=Sing	_	_	_	_
23	Shift	shift	PROPN	NNP	Number=Sing	_	_	_	_
24	Assay	assay	PROPN	NNP	Number=Sing	_	_	_	_
25	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
27	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	enabled	enable	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	ex	ex	ADJ	JJ	Degree=Pos	_	_	_	_
40	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
41	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
43	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
44	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11082
# text = We examined 33 patients with diabetes mellitus (Type I and
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	33	33	NUM	CD	NumType=Card	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	_
7	mellitus	mellitus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	Type	type	NOUN	NN	Number=Sing	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_

# sent_id = 11083
# text = Type II).
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11084
# text = Patients with diabetic nephropathy showed higher NF-kappaB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kappaBp65 than patients without renal complications.
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
4	nephropathy	nephropathy	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Electrophoretic	Electrophoretic	PROPN	NNP	Number=Sing	_	_	_	_
14	Mobility	Mobility	PROPN	NNP	Number=Sing	_	_	_	_
15	Shift	shift	PROPN	NNP	Number=Sing	_	_	_	_
16	Assays	Assays	PROPN	NNPS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
19	immunohistological	immunohistological	ADJ	JJ	Degree=Pos	_	_	_	_
20	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaBp65	kappaBp65	PROPN	NNP	Number=Sing	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
28	without	without	ADP	IN	_	_	_	_	_
29	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
30	complications	complication	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11085
# text = NF-kappaB binding activity correlated with the degree of albuminuria (r = 0.316) and with thrombomodulin plasma concentrations (r = 0.33), indicative for albuminuria associated endothelial dysfunction.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	albuminuria	albuminuria	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	r	be	NOUN	NN	Number=Sing	_	_	_	_
14	=	=	SYM	SYM	_	_	_	_	_
15	0.316	0.316	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	thrombomodulin	thrombomodulin	NOUN	NN	Number=Sing	_	_	_	_
20	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
21	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	r	be	NOUN	NN	Number=Sing	_	_	_	_
24	=	=	SYM	SYM	_	_	_	_	_
25	0.33	0.33	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	indicative	indicative	ADJ	JJ	Degree=Pos	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	albuminuria	albuminurion	X	GW	_	_	_	_	_
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
33	dysfunction	dysfunction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11086
# text = In a 3 day intervention study in which 600 mg of the antioxidant thioctic acid (alpha-lipoic acid) per day were given to nine patients with diabetic nephropathy oxidative stress in plasma samples was decreased by 48% and NF-kappaB binding activity in ex vivo isolated peripheral blood mononuclear cells by 38%.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	day	day	NOUN	NN	Number=Sing	_	_	_	_
5	intervention	intervention	NOUN	NN	Number=Sing	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	600	600	NUM	CD	NumType=Card	_	_	_	_
10	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
14	thioctic	thioctic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
20	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	per	per	ADP	IN	_	_	_	_	_
23	day	day	NOUN	NN	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	given	give	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	nine	nine	NUM	CD	NumType=Card	_	_	_	_
28	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
31	nephropathy	nephropathy	NOUN	NN	Number=Sing	_	_	_	_
32	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
33	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
36	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	%	%	SYM	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	ex	ex	ADJ	JJ	Degree=Pos	_	_	_	_
50	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
51	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
53	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
54	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
56	by	by	ADP	IN	_	_	_	_	_
57	38%	38%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11087
# text = In conclusion, activation of the transcription factor NF-kappaB in ex vivo isolated peripheral blood mononuclear cells of patients with diabetes mellitus correlates with the degree of diabetic nephropathy.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	ex	ex	NUM	CD	NumType=Card	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
15	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	diabetes	diabete	NOUN	NNS	Number=Plur	_	_	_	_
24	mellitus	mellitus	CCONJ	CC	_	_	_	_	_
25	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	diabetic	diabetic	ADJ	JJ	Degree=Pos	_	_	_	_
31	nephropathy	nephropathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11088
# text = NF-kappaB activation is at least in part dependent on oxidative stress since thioctic acid (alpha-lipoic acid) reduced NF-kappaB binding activity.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	at	at	ADV	RB	_	_	_	_	_
7	least	least	ADV	RBS	Degree=Sup	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	part	part	ADJ	JJ	Degree=Pos	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
13	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
14	since	since	ADP	IN	_	_	_	_	_
15	thioctic	thioctic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	lipoic	lipoic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11089
# text = Document 0030012434 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012434	0030012434	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11090
# text = Oxidative stress suppresses transcription factor activities in stimulated lymphocytes.
1	Oxidative	Oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
2	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
3	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	stimulated	stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11091
# text = Effects of oxidative stress on stimulation-dependent signal transduction, leading to IL-2 expression, were studied.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
4	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11092
# text = Purified quiescent human blood T lymphocytes were subjected to: (i) acute exposure to hydrogen peroxide; (ii) chronic exposure to hydrogen peroxide; and (iii) acute exposure to ionizing radiation.
1	Purified	Purify	ADJ	JJ	Degree=Pos	_	_	_	_
2	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	subjected	subject	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	i	i	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	hydrogen	hydrogen	VERB	VB	VerbForm=Inf	_	_	_	_
18	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
24	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	hydrogen	hydrogen	VERB	VB	VerbForm=Inf	_	_	_	_
27	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	;	;	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
34	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	SCONJ	IN	_	_	_	_	_
36	ionizing	ionizing	VERB	VBG	VerbForm=Ger	_	_	_	_
37	radiation	radiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11093
# text = The cells were then stimulated for 6 h.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11094
# text = DNA-binding activities (determined by the electrophoretic mobility shift assay) of three transcription factors: NFkappaB, AP-1 and NFAT, were abolished in the lymphocytes by all three modes of oxidative stress.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
10	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
11	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	three	three	NUM	CD	NumType=Card	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	NFkappaB	Nfkappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	all	all	DET	DT	_	_	_	_	_
34	three	three	NUM	CD	NumType=Card	_	_	_	_
35	modes	mode	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
38	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11095
# text = The lymphocytes exhibited lipid peroxidation only upon exposure to the lowest level of hydrogen peroxide used (20 microM).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
5	peroxidation	peroxidation	NOUN	NN	Number=Sing	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	upon	upon	ADP	IN	_	_	_	_	_
8	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	lowest	lowest	ADJ	JJS	Degree=Sup	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	hydrogen	hydrogen	NOUN	NN	Number=Sing	_	_	_	_
15	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	20	20	NUM	CD	NumType=Card	_	_	_	_
19	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11096
# text = All three modes of oxidative stress induced catalase activity in the lymphocytes.
1	All	all	DET	DT	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	modes	mode	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
6	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11097
# text = The only exception was hydrogen peroxide at 20 microM, which did not induce catalase activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
3	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	hydrogen	hydrogen	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	peroxide	peroxide	ADV	RB	_	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	_
9	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	catalase	catalase	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11098
# text = We conclude that: (i) suppression of specific transcription factor functions can potentially serve as a marker of exposure to oxidative stress and its effects on human lymphocytes; (ii) lipid peroxidation is only detectable in human lymphocytes upon exposure to weak oxidative stress which does not induce catalase activity; (iii) therefore, transcription factor DNA-binding activities are more sensitive to oxidative stress than lipid peroxidation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	i	i	X	LS	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	potentially	potentially	ADV	RB	_	_	_	_	_
16	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
24	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
36	peroxidation	peroxidation	NOUN	NN	Number=Sing	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	only	only	ADV	RB	_	_	_	_	_
39	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
43	upon	upon	ADP	IN	_	_	_	_	_
44	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	weak	weak	VERB	VB	VerbForm=Inf	_	_	_	_
47	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
48	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
49	which	which	PRON	WDT	PronType=Rel	_	_	_	_
50	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
51	not	not	PART	RB	_	_	_	_	_
52	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
53	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	_
54	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	;	;	PUNCT	,	_	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	_
59	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
60	,	,	PUNCT	,	_	_	_	_	_
61	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
62	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
63	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
66	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
67	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
68	more	more	ADV	RBR	_	_	_	_	_
69	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
70	to	to	ADP	IN	_	_	_	_	_
71	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
72	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
73	than	than	ADP	IN	_	_	_	_	_
74	lipid	lipid	ADJ	JJ	Degree=Pos	_	_	_	_
75	peroxidation	peroxidation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11099
# text = Document 0030012440 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012440	0030012440	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11100
# text = Induction of NF-kappa B during monocyte differentiation is associated with activation of HIV-gene expression.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11101
# text = Cells of the monocyte-macrophage lineage are important targets of HIV infection.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
7	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11102
# text = We report here that the phenotypic differentiation of monocyte cell lines induced by phorbol esters or tumour necrosis factor alpha (TNF alpha) is associated with expression of nuclear factor kappa B (NF-kappa B).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11103
# text = In parallel with such differentiation, HIV transcription, monitored using an HIV long terminal repeat reporter gene construct, is activated in such cells under the influence of enhanced NF-kappa B expression.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	monitored	monitor	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
14	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
15	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
16	repeat	repeat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11104
# text = Also, in a promonocyte cell line chronically infected with HIV, NF-kappa B expression and HIV transcription were enhanced on stimulation with phorbol ester or TNF alpha.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	promonocyte	promonocyte	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	chronically	chronically	ADV	RB	_	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
27	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
30	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11105
# text = Thus, stimulation of monocyte cell lines by phorbol esters or TNF alpha induces cell differentiation and activates HIV transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
10	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
13	alpha	alpha	ADV	RB	_	_	_	_	_
14	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11106
# text = Such a process may have fundamental implications in AIDS pathogenesis in vivo and may be important in disease progression induced by opportunistic infections directly or indirectly involving macrophages.
1	Such	such	DET	PDT	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	process	process	NOUN	NN	Number=Sing	_	_	_	_
4	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
5	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
6	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
7	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	AIDS	aids	NOUN	NN	Number=Sing	_	_	_	_
10	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
19	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	opportunistic	opportunistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
24	directly	directly	ADV	RB	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	indirectly	indirectly	ADV	RB	_	_	_	_	_
27	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
28	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11107
# text = Document 0030012441 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012441	0030012441	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11108
# text = Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.
1	Hypoxia	Hypoxia	PROPN	NNP	Number=Sing	_	_	_	_
2	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
16	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11109
# text = The response of mammalian cells to stress is controlled by transcriptional regulatory proteins such as nuclear factor kappa B (NF-kappa B) to induce a wide variety of early response genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
30	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11110
# text = In this report, we show that exposure of cells to hypoxia (0.02% O2) results in I kappa B alpha degradation, increased NF-kappa B DNA binding activity, and transactivation of a reporter gene construct containing two NF-kappa B DNA binding sites.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	0.02	0.02	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	%	%	SYM	NN	Number=Sing	_	_	_	_
16	O2	O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	results	result	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappa	kappa	X	GW	_	_	_	_	_
22	B	b	X	GW	_	_	_	_	_
23	alpha	alpha	X	GW	_	_	_	_	_
24	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
42	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
43	two	two	NUM	CD	NumType=Card	_	_	_	_
44	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
47	B	b	NOUN	NN	Number=Sing	_	_	_	_
48	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
49	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
50	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11111
# text = Pretreatment of cells with protein tyrosine kinase inhibitors and the dominant negative allele of c-Raf-1 (Raf 301) inhibited I kappa B alpha degradation, NF-kappa B binding, and transactivation of kappa B reporter constructs by hypoxia.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	_
22	301	301	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
41	B	b	NOUN	NN	Number=Sing	_	_	_	_
42	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
43	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11112
# text = To demonstrate a direct link between changes in the phosphorylation pattern of I kappa B alpha with NF-kappa B activation, we immunoprecipitated I kappa B alpha after varying times of hypoxic exposure and found that its tyrosine phosphorylation status increased during hypoxic exposure.
1	To	to	PART	TO	_	_	_	_	_
2	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	link	link	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	immunoprecipitated	immunoprecipitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	alpha	alpha	ADV	RB	_	_	_	_	_
30	after	after	SCONJ	IN	_	_	_	_	_
31	varying	vary	VERB	VBG	VerbForm=Ger	_	_	_	_
32	times	time	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	hypoxic	hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
35	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	that	that	SCONJ	IN	_	_	_	_	_
39	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
41	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
42	status	status	NOUN	NN	Number=Sing	_	_	_	_
43	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	during	during	ADP	IN	_	_	_	_	_
45	hypoxic	hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
46	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11113
# text = Inhibition of the transfer of tyrosine phosphoryl groups onto I kappa B alpha prevented I kappa B alpha degradation and NF-kappa B binding.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphoryl	phosphoryl	NOUN	NN	Number=Sing	_	_	_	_
8	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
9	onto	onto	ADP	IN	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	B	PROPN	NNP	Number=Sing	_	_	_	_
13	alpha	alpha	ADV	RB	_	_	_	_	_
14	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	ADP	IN	_	_	_	_	_
19	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11114
# text = In comparison to other activators of NF-kappa B such as phorbol myristate acetate or tumor necrosis factor, we did not detect changes in the tyrosine phosphorylation status of I kappa B alpha following treatment with either of these agents.
1	In	in	ADP	IN	_	_	_	_	_
2	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
14	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
15	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
25	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
29	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
30	status	status	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
37	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	either	either	CCONJ	CC	_	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11115
# text = These results suggest that tyrosine phosphorylation of I kappa B alpha during hypoxia is an important proximal step which precedes its dissociation and degradation from NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	step	step	NOUN	NN	Number=Sing	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	precedes	precede	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11116
# text = Document 0030012443 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012443	0030012443	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11117
# text = A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria [see comments]
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	OCT	oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
18	malaria	malaria	NOUN	NN	Number=Sing	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	see	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11118
# text = Genetic variation in cytokine promoter regions is postulated to influence susceptibility to infection, but the molecular mechanisms by which such polymorphisms might affect gene regulation are unknown.
1	Genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
2	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
11	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	which	which	DET	WDT	PronType=Int	_	_	_	_
21	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
22	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
23	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
24	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
25	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11119
# text = Through systematic DNA footprinting of the TNF (encoding tumour necrosis factor, TNF) promoter region, we have identified a single nucleotide polymorphism (SNP) that causes the helix-turn-helix transcription factor OCT-1 to bind to a novel region of complex protein-DNA interactions and alters gene expression in human monocytes.
1	Through	through	ADP	IN	_	_	_	_	_
2	systematic	systematic	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	tumour	tumour	NUM	CD	NumType=Card	_	_	_	_
11	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
24	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
25	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	SNP	SNP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	OCT	oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
47	region	region	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
50	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
53	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
56	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
60	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11120
# text = The OCT-1-binding genotype, found in approximately 5% of Africans, is associated with fourfold increased susceptibility to cerebral malaria in large case-control studies of
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	OCT	Oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	approximately	approximately	ADV	RB	_	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	%	%	SYM	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Africans	Africans	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	fourfold	fourfold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	cerebral	cerebral	ADJ	JJ	Degree=Pos	_	_	_	_
25	malaria	malarion	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
28	case	case	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_

# sent_id = 11121
# text = West African and East African populations, after correction for other known TNF polymorphisms and linked HLA alleles.
1	West	West	PROPN	NNP	Number=Sing	_	_	_	_
2	African	African	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	East	East	PROPN	NNP	Number=Sing	_	_	_	_
5	African	african	ADJ	JJ	Degree=Pos	_	_	_	_
6	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	correction	correction	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	TNF	Tnf	ADP	RP	_	_	_	_	_
14	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	HLA	Hla	PROPN	NNP	Number=Sing	_	_	_	_
18	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11122
# text = Document 0030012448 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012448	0030012448	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11123
# text = NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11124
# text = C5a, a potent peptide chemoattractant, stimulates interleukin-8 (IL-8) secretion from peripheral blood mononuclear cells (PBMC).
1	C5a	C5a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
5	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
6	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	8	8	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11125
# text = Experiments were conducted to understand the mechanisms for C5a-induced IL-8 production, which was 14-fold greater than that in unstimulated cells by 2 hours.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	a-	a-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	8	8	NUM	CD	NumType=Card	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
22	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11126
# text = IL-8 secretion was accompanied by accumulation of IL-8 mRNA in the cytosol and by nuclear expression of a kappaB DNA binding activity within 30 minutes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	8	8	NUM	CD	NumType=Card	_	_	_	_
4	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	within	within	ADP	IN	_	_	_	_	_
28	30	30	NUM	CD	NumType=Card	_	_	_	_
29	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11127
# text = AP-1 but not NF-IL-6 DNA binding activity was also detected in C5a-stimulated PBMC; however, its delayed expression (maximal at 4 hours) suggested a less important role in the rapid production of IL-8.
1	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
26	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	delayed	delay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
38	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
39	role	role	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
43	production	production	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11128
# text = The correlation between C5a-induced kappaB binding activity and IL-8 gene expression was examined in the RAW264.7 macrophage cells using reporter genes directed by the kappaB sequence from IkappaBalpha and IL-8 promoter regions.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
22	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
31	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	8	8	NUM	CD	NumType=Card	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11129
# text = C5a-induced reporter gene expression was abolished by introducing mutations into the kappaB sites and by coexpression of a dominant negative IkappaBalpha construct resistant to agonist-induced phosphorylation.
1	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	introducing	introduce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
24	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
25	construct	construct	ADJ	JJ	Degree=Pos	_	_	_	_
26	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	agonist	agonist	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
29	-induced	-induce	ADJ	JJ	Degree=Pos	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11130
# text = Pertussis toxin, which ADP-ribosylates the Gi proteins known to couple to the C5a receptor, produced minimal inhibition of C5a-induced IL-8 expression and had little effect on C5a-induced calcium mobilization in RAW264.7 cells.
1	Pertussis	Pertussis	PROPN	NNP	Number=Sing	_	_	_	_
2	toxin	toxin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	DET	WDT	PronType=Int	_	_	_	_
5	ADP	ADP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	ribosylates	ribosylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Gi	gi	PROPN	NNP	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	couple	couple	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
22	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	a-	a-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	8	8	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
34	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
40	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11131
# text = These results suggest that NF-kappaB activation is required for C5a-induced IL-8 gene expression and that this response is mediated primarily through a pertussis toxin-insensitive pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	C5	C5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	a-	a-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	8	8	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	primarily	primarily	ADV	RB	_	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	pertussis	pertussis	NOUN	NN	Number=Sing	_	_	_	_
30	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
33	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11132
# text = Document 0030012461 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012461	0030012461	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11133
# text = CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes.
1	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
15	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
21	multi-protein	multi-protein	NOUN	NN	Number=Sing	_	_	_	_
22	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11134
# text = Precise regulation of MHC class II expression plays a crucial role in the control of the immune response.
1	Precise	precise	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	control	control	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11135
# text = The transactivator CIITA behaves as a master controller of constitutive and inducible MHC class II gene activation, but its exact mechanism of action is not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
3	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
4	behaves	behave	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	master	master	NOUN	NN	Number=Sing	_	_	_	_
8	controller	controller	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
21	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	exact	exact	ADV	RB	_	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	action	action	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11136
# text = Activation of MHC class II promoters requires binding of at least three distinct multi-protein complexes (RFX, X2BP and NF-Y).
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	at	at	ADV	RB	_	_	_	_	_
11	least	least	ADV	RBS	Degree=Sup	_	_	_	_
12	three	three	NUM	CD	NumType=Card	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	multi-protein	multi-protein	NOUN	NN	Number=Sing	_	_	_	_
15	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RFX	RFX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	X2BP	X2BP	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11137
# text = It is known that the stability of this binding results from cooperative interactions between these proteins.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11138
# text = We show here that expression of CIITA in MHC class II- cells triggers occupation of the promoters by these complexes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
15	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11139
# text = This observation raised the possibility that the effect of CIITA on promoter occupation is mediated by an effect on the cooperative stabilization of the DNA-bound multi-protein complexes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	raised	raise	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
22	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
28	multi-protein	multi-protein	NOUN	NN	Number=Sing	_	_	_	_
29	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11140
# text = We show, however, that the presence of CIITA does not affect the stability of the higher-order protein complex formed on DNA by RFX, X2BP and NF-Y.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	order	order	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	RFX	RFX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	X2BP	X2BP	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11141
# text = This suggests other mechanisms for CIITA-induced promoter occupancy, such as an effect on chromatin structure leading to increased accessibility of MHC class II promoters.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
18	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
19	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	accessibility	accessibility	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
25	class	class	NOUN	NN	Number=Sing	_	_	_	_
26	II	ii	NUM	CD	NumType=Card	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11142
# text = This ability of CIITA to facilitate promoter occupation is undissociable from its transactivation potential.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	undissociable	undissociable	ADJ	JJ	Degree=Pos	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
14	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11143
# text = Finally, we conclude that this effect of CIITA is cell-type specific, since expression of CIITA is not required for normal occupation of MHC class II promoters in B lymphocytes.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	since	since	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	occupation	occupation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
28	class	class	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11144
# text = Document 0030012465 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012465	0030012465	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11145
# text = Activation of distinct transcription factors in neutrophils by bacterial LPS, interferon-gamma, and GM-CSF and the necessity to overcome the action of endogenous proteases.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
10	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	necessity	necessity	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
29	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11146
# text = Human neutrophils can be induced to actively transcribe a number of early-response genes, in particular those encoding cytokines, chemokines, and the high-affinity surface receptor for IgG, FcgammaRI.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	actively	actively	ADV	RB	_	_	_	_	_
8	transcribe	transcribe	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	number	number	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
19	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
21	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	FcgammaRI	FcgammaRI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11147
# text = Although little is known to date about the regulation of gene transcription in neutrophils, several indications point to a role for distinct transcription factors, such as members of the NF-kappaB and STAT families.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	date	date	NOUN	NN	Number=Sing	_	_	_	_
7	about	about	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
17	indications	indication	NOUN	NNS	Number=Plur	_	_	_	_
18	point	point	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	members	member	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
37	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11148
# text = In this study, we investigated whether these transcription factors become activated under stimulatory conditions which are known to induce gene transcription in neutrophils.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	under	under	ADP	IN	_	_	_	_	_
14	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11149
# text = Unexpectedly, we found that conventional procedures employed to prepare cellular extracts cause the release of proteolytic activities that are normally stored in intracellular granules, resulting in the degradation of various NF-kappaB/Rel and STAT proteins.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	conventional	conventional	ADJ	JJ	Degree=Pos	_	_	_	_
7	procedures	procedure	NOUN	NNS	Number=Plur	_	_	_	_
8	employed	employ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	prepare	prepare	VERB	VB	VerbForm=Inf	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	cause	cause	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	release	release	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	normally	normally	ADV	RB	_	_	_	_	_
22	stored	store	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11150
# text = To circumvent this problem, we developed an alternative procedure which allowed us to show that in neutrophils, LPS and TNFalpha induce a NF-kappaB DNA-binding activity which essentially consists of p50/RelA dimers, and that IFNgamma promotes the binding of STAT1 homodimers to the IFNgamma response region of the FcgammaRI promoter.
1	To	to	PART	TO	_	_	_	_	_
2	circumvent	circumvent	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	problem	problem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
10	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
23	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	essentially	essentially	ADV	RB	_	_	_	_	_
34	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
37	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	_
38	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
43	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
48	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	_
52	response	response	NOUN	NN	Number=Sing	_	_	_	_
53	region	region	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	FcgammaRI	FcgammaRI	PROPN	NNP	Number=Sing	_	_	_	_
57	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11151
# text = Moreover, we report that neutrophil stimulation with GM-CSF results in the formation of a STAT5-containing DNA-binding activity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
12	results	result	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	STAT5	STAT5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11152
# text = Collectively, the current findings open new perspectives about mechanisms that are likely to regulate gene transcription in neutrophils.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
7	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
8	perspectives	perspective	NOUN	NNS	Number=Plur	_	_	_	_
9	about	about	ADP	IN	_	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11153
# text = In addition, the procedure described herein could prove useful in other cell types that express high levels of endogenous proteases.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	_
6	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	herein	herein	ADV	RB	_	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
10	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	types	type	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11154
# text = Document 0030012472 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012472	0030012472	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11155
# text = Transcription of the hypersensitive site HS2 enhancer in erythroid cells.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	HS2	Hs2	NUM	CD	NumType=Card	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11156
# text = In the human genome, the erythroid-specific hypersensitive site HS2 enhancer regulates the transcription of the downstream beta-like globin genes 10-50 kilobases away.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	HS2	HS2	NUM	CD	NumType=Card	_	_	_	_
13	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
14	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	50	50	NUM	CD	NumType=Card	_	_	_	_
28	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
29	away	away	ADV	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11157
# text = The mechanism of HS2 enhancer function is not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HS2	HS2	NUM	CD	NumType=Card	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11158
# text = The present study employs RNA protection assays to analyze the transcriptional status of the HS2 enhancer in transfected recombinant chloramphenicol acetyltransferase (CAT) plasmids.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	employs	employ	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	RNA	RNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
7	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	status	status	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HS2	Hs2	NOUN	NN	Number=Sing	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
20	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
21	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11159
# text = In erythroid K562 cells in which the HS2 enhancer is active, the HS2 sequence directs the synthesis of long enhancer transcripts that are initiated apparently from within the enhancer and elongated through the intervening DNA into the cis-linked CAT gene.
1	In	in	ADP	IN	_	_	_	_	_
2	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	K562	K562	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HS2	Hs2	NOUN	NN	Number=Sing	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	HS2	Hs2	NOUN	NN	Number=Sing	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
16	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	apparently	apparently	ADV	RB	_	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	within	within	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	elongated	elongate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	through	through	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	intervening	intervene	VERB	VBG	VerbForm=Ger	_	_	_	_
36	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
37	into	into	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cis	cis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
40	-linked	-link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11160
# text = In nonerythroid HL-60 cells in which the HS2 enhancer is inactive, long enhancer transcripts are not detectable.
1	In	in	ADP	IN	_	_	_	_	_
2	nonerythroid	nonerythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HS2	Hs2	NOUN	NN	Number=Sing	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11161
# text = Splitting the HS2 enhancer between two tandem Ap1 sites abolishes the synthesis of a group of long enhancer transcripts and results in loss of enhancer function and transcriptional silencing of the cis-linked CAT gene.
1	Splitting	split	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	HS2	Hs2	NOUN	NN	Number=Sing	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
8	Ap1	Ap1	NUM	CD	NumType=Card	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	group	group	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	results	result	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	silencing	silencing	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cis	cis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
33	-linked	-link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11162
# text = In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site.
1	In	in	SCONJ	IN	_	_	_	_	_
2	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	intervening	intervening	VERB	VBG	VerbForm=Ger	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	tracking	tracking	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HS2	Hs2	NOUN	NN	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	i	i	X	LS	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	open	open	VERB	VB	VerbForm=Inf	_	_	_	_
29	up	up	ADP	RP	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
32	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	deliver	deliver	NOUN	NN	Number=Sing	_	_	_	_
42	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
43	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
44	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
48	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
49	where	where	ADV	WRB	PronType=Rel	_	_	_	_
50	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
51	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
52	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
58	at	at	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	cap	cap	NOUN	NN	Number=Sing	_	_	_	_
61	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11163
# text = Document 0030012485 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012485	0030012485	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11164
# text = Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells.
1	Low	low	ADV	RB	Degree=Pos	_	_	_	_
2	CD3+CD28-induced	CD3+CD28-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
11	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
12	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
13	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11165
# text = The capacity of neonatal T cells to secrete interleukin-2 (IL-2) has been reported to be variable.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	secrete	secrete	VERB	VB	VerbForm=Inf	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11166
# text = We analysed IL-2 production in purified neonatal and adult T cells using polyclonal activator phorbol ester + calcium ionophore (PDBu + iono) or receptor-mediated anti-CD3/anti-CD3+ anti-CD28 stimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analysed	analyse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
9	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
19	+	+	SYM	SYM	_	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
21	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	PDBu	PDBu	NOUN	NN	Number=Sing	_	_	_	_
24	+	+	SYM	SYM	_	_	_	_	_
25	iono	iono	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	receptor-	receptor-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	anti-CD3/anti-CD3+	anti-CD3/anti-CD3+	SYM	SYM	_	_	_	_	_
31	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
32	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11167
# text = PDBu + iono induced equally high IL-2 levels in both groups and, when stimulated with plate-bound anti-CD3 monoclonal antibody (mAb), the IL-2 secretion by neonatal cells was undetectable and adult cells produced low amounts of IL-2 (mean 331 +/- 86 pg/ml).
1	PDBu	PDBu	PROPN	NNP	Number=Sing	_	_	_	_
2	+	+	SYM	SYM	_	_	_	_	_
3	iono	iono	ADV	RB	_	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	equally	equally	ADV	RB	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	plate	plate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-bound	-bound	NOUN	NN	Number=Sing	_	_	_	_
21	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
22	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
23	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
43	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	2	2	NUM	CD	NumType=Card	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	mean	mean	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	331	331	NUM	CD	NumType=Card	_	_	_	_
51	+/-	+/-	SYM	SYM	_	_	_	_	_
52	86	86	NUM	CD	NumType=Card	_	_	_	_
53	pg/ml	pg/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11168
# text = The addition of anti-CD28 mAb to anti-CD3-stimulated cells markedly increased IL-2 production in both cell types, but levels of IL-2 in neonatal T cells remained clearly lower than those of adult T cells (respective mean values: 385 +/- 109 pg/ml and 4494 +/- 1199 pg/ml).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
5	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-stimulated	-stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	markedly	markedly	ADV	RB	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	T	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	clearly	clearly	ADV	RB	_	_	_	_	_
33	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
34	than	than	ADP	IN	_	_	_	_	_
35	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
42	mean	mean	NOUN	NN	Number=Sing	_	_	_	_
43	values	value	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	:	:	PUNCT	:	_	_	_	_	_
45	385	385	NUM	CD	NumType=Card	_	_	_	_
46	+/-	+/-	SYM	SYM	_	_	_	_	_
47	109	109	NUM	CD	NumType=Card	_	_	_	_
48	pg/ml	pg/ml	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	4494	4494	NUM	CD	NumType=Card	_	_	_	_
51	+/-	+/-	SYM	SYM	_	_	_	_	_
52	1199	1199	NUM	CD	NumType=Card	_	_	_	_
53	pg/ml	pg/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11169
# text = As NF-kappa B is a critical transcription factor in the control of IL-2 expression, we next analysed its nuclear translocation in neonatal and adult T cells using the electrophoretic mobility shift assay and, because induction of reactive oxygen intermediates (ROI) is required for the activation of NF-kappa B, we also analysed levels of intracellular ROI in these cells using the ROI-reactive fluorochrome DCFH-DA and flow cytometry.
1	As	as	ADP	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	b	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	next	next	ADV	RB	_	_	_	_	_
22	analysed	analyse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
35	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
36	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
37	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	because	because	SCONJ	IN	_	_	_	_	_
41	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
44	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
45	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
51	for	for	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
58	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
61	also	also	ADV	RB	_	_	_	_	_
62	analysed	analyse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
63	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
66	ROI	ROI	NOUN	NNS	Number=Plur	_	_	_	_
67	in	in	ADP	IN	_	_	_	_	_
68	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
69	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
70	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
71	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
72	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
73	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
74	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
75	fluorochrome	fluorochrome	NOUN	NN	Number=Sing	_	_	_	_
76	DCFH	DCFh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	DA	da	NOUN	NN	Number=Sing	_	_	_	_
79	and	and	CCONJ	CC	_	_	_	_	_
80	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
81	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11170
# text = In neonatal T cells NF-kappa B activation and ROI formation after anti-CD3 stimulation were low compared with adult T cells and, although addition of anti-CD28 mAb increased induction of NF-kappa B and ROI formation, levels similar to those of adults were not achieved.
1	In	in	ADP	IN	_	_	_	_	_
2	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	ROI	Roi	NOUN	NN	Number=Sing	_	_	_	_
12	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	although	although	SCONJ	IN	_	_	_	_	_
26	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
29	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
30	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	ROI	Roi	PROPN	NNP	Number=Sing	_	_	_	_
39	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
42	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	adults	adult	NOUN	NNS	Number=Plur	_	_	_	_
47	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11171
# text = After PDBu + iono stimulation, the cells showed similar ROI formation and IL-2 secretion.
1	After	after	SCONJ	IN	_	_	_	_	_
2	PDBu	PDBu	PROPN	NNP	Number=Sing	_	_	_	_
3	+	+	SYM	SYM	_	_	_	_	_
4	iono	iono	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	ROI	Roi	NOUN	NN	Number=Sing	_	_	_	_
12	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11172
# text = Our results suggest that reduced IL-2 production by neonatal T cells is specific for anti-CD3 and anti-CD3+ anti-CD28-mediated stimulation and that these activators cannot effectively activate the ROI-NF-kappa B signalling pathway in neonatal T cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
29	not	not	PART	RB	_	_	_	_	_
30	effectively	effectively	ADV	RB	_	_	_	_	_
31	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	ROI	Roi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
40	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11173
# text = Document 0030012490 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012490	0030012490	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11174
# text = Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain.
1	Control	Control	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFATx1	NFATx1	NUM	CD	NumType=Card	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	calcineurin-	calcineurin-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11175
# text = The nuclear factor of activated T cells (NFAT) regulates cytokine gene expression in T cells through cis-acting elements located in the promoters of several cytokine genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T	T	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	cytokine	cytokine	PRON	PRP	_	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
29	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11176
# text = NFATx1, which is preferentially expressed in the thymus and peripheral blood leukocytes, is one of four members of the NFAT family of transcription factors.
1	NFATx1	NFATx1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	preferentially	preferentially	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	four	four	NUM	CD	NumType=Card	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11177
# text = We have performed domain analysis of NFATx1 by examining the effects of deletion mutations.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	domain	domain	ADJ	JJ	Degree=Pos	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NFATx1	NFATx1	PROPN	NNP	Number=Sing	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	examining	examine	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
14	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11178
# text = We found that NFATx1 DNA binding activity and interaction with AP-1 polypeptides were dependent on its central Rel similarity region and that transcriptional activation was reduced by deletions of either its N-terminal domain or its C-terminal domain, suggesting the presence of intrinsic transcriptional activation motifs in both regions.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NFATx1	NFATx1	PROPN	NNP	Number=Sing	_	_	_	_
5	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	polypeptides	polypeptide	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
20	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
21	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	either	either	CCONJ	CC	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
36	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
39	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
41	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
50	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	both	both	DET	DT	_	_	_	_	_
53	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11179
# text = We also identified a potent inhibitory sequence within its N-terminal domain.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11180
# text = We show that the inactivation of the inhibition was dependent on the activity of calcineurin, a calcium-calmodulin-dependent phosphatase.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	calcium-calmodulin	calcium-calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11181
# text = We also show that calcineurin associated with the N-terminal domain of NFATx1 at multiple docking sites and caused a reduction of size, indicative of dephosphorylation, in NFATx1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NFATx1	Nfatx1	PROPN	NNP	Number=Sing	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	docking	docking	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	size	size	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicative	indicative	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	ATx1	ATx1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11182
# text = We have mapped the inhibitory activity to less than 60 residues, containing motifs that are conserved in all NFAT proteins.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	less	less	VERB	VB	VerbForm=Inf	_	_	_	_
9	than	than	ADP	IN	_	_	_	_	_
10	60	60	NUM	CD	NumType=Card	_	_	_	_
11	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	all	all	DET	DT	_	_	_	_	_
20	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11183
# text = Finally, we demonstrate that deletion in NFATx1 of the mapped 60 residues leads to its nuclear translocation independent of calcium signaling.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	NFATx1	NFATx1	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mapped	map	ADJ	JJ	Degree=Pos	_	_	_	_
12	60	60	NUM	CD	NumType=Card	_	_	_	_
13	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
22	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11184
# text = Our results support the model proposing that the N-terminal domain confers calcium-signaling dependence on NFATx1 transactivation activity by regulating its intracellular localization through a protein module that associates with calcineurin and is a target of its phosphatase activity.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	proposing	propose	VERB	VBG	VerbForm=Ger	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
13	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	NFATx1	NFATx1	NUM	CD	NumType=Card	_	_	_	_
19	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	module	module	NOUN	NN	Number=Sing	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	target	target	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11185
# text = Document 0030012492 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012492	0030012492	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11186
# text = Precise alignment of sites required for mu enhancer activation in B cells.
1	Precise	precise	NOUN	NN	Number=Sing	_	_	_	_
2	alignment	alignment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11187
# text = The lymphocyte-specific immunoglobulin mu heavy-chain gene intronic enhancer is regulated by multiple nuclear factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
6	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
7	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-chain	-chain	ADJ	JJ	Degree=Pos	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	intronic	intronic	ADJ	JJ	Degree=Pos	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11188
# text = The previously defined minimal enhancer containing the muA, muE3, and muB sites is transactivated by a combination of the ETS-domain proteins PU.1 and Ets-1 in nonlymphoid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	muA	mua	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	muE3	muE3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	muB	mub	NOUN	NN	Number=Sing	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	ETS	Et	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
26	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11189
# text = The core GGAAs of the muA and muB sites are separated by 30 nucleotides, suggesting that ETS proteins bind to these sites from these same side of the DNA helix.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	core	core	NOUN	NN	Number=Sing	_	_	_	_
3	GGAAs	GGAA	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	muA	mua	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	muB	mub	NOUN	NN	Number=Sing	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	30	30	NUM	CD	NumType=Card	_	_	_	_
14	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	proteins	NOUN	NNS	Number=Plur	_	_	_	_
20	bind	bind	ADP	IN	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
27	side	side	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11190
# text = We tested the necessity for appropriate spatial alignment of these elements by using mutated enhancers with altered spacings.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	necessity	necessity	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
7	spatial	spatial	ADJ	JJ	Degree=Pos	_	_	_	_
8	alignment	alignment	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	spacings	spacing	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11191
# text = A 4- or 10-bp insertion between muE3 and muB inactivated the mu enhancer in S194 plasma cells but did not affect in vitro binding of Ets-1, PU.1, or the muE3-binding protein TFE3, alone or in pairwise combinations.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
8	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	muE3	muE3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	muB	muB	PROPN	NNP	Number=Sing	_	_	_	_
13	inactivated	inactivate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	S194	S194	NUM	CD	NumType=Card	_	_	_	_
19	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
30	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	muE3	muE3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	TFE3	TFE3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	pairwise	pairwise	ADJ	JJ	Degree=Pos	_	_	_	_
46	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11192
# text = Circular permutation and phasing analyses demonstrated that PU.1 binding but not TFE3 or Ets-1 bends mu enhancer DNA toward the major groove.
1	Circular	circular	ADJ	JJ	Degree=Pos	_	_	_	_
2	permutation	permutation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	phasing	phasing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	TFE3	TFE3	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	bends	bend	NOUN	NNS	Number=Plur	_	_	_	_
18	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	toward	toward	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
24	groove	groove	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11193
# text = We propose that the requirement for precise spacing of the muA and muB elements is due in part to a directed DNA bend induced by PU.1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
8	spacing	spacing	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	muA	mua	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	muB	mub	NOUN	NN	Number=Sing	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	part	part	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	bend	bend	NOUN	NN	Number=Sing	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11194
# text = Document 0030012495 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012495	0030012495	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11195
# text = Regulation of the megakaryocytic glycoprotein IX promoter by the oncogenic Ets transcription factor Fli-1. Glycoprotein (GP) IX is a subunit of the von Willebrand receptor, GPIb-V-IX, which mediates adhesion of platelets to the subendothelium of damaged blood vessels.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
6	IX	ix	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	X	LS	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n
18	Glycoprotein	Glycoprotein	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GP	GP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	IX	Ix	PROPN	NNP	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	von	von	PROPN	NNP	Number=Sing	_	_	_	_
29	Willebrand	Willebrand	PROPN	NNP	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	GPIb	GPIb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	V	V	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	IX	IX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	subendothelium	subendothelium	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	damaged	damage	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
49	vessels	vessel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11196
# text = Previous characterization of the GPIX promoter identified a functional Ets site that, when disrupted, reduced promoter activity.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GPIX	GPIX	PROPN	NNP	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	ADV	WRB	PronType=Rel	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	disrupted	disrupt	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11197
# text = However, the Ets protein(s) that regulated GPIX promoter expression was unknown.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	s	s	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	regulated	regulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	GPIX	Gpix	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11198
# text = In this study, transient cotransfection of several GPIX promoter/reporter constructs into 293T kidney fibroblasts with a Fli-1 expression vector shows that the oncogenic protein Fli-1 can transactivate the GPIX promoter when an intact GPIX Ets site is present.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
6	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	GPIX	GPIX	PROPN	NNP	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
13	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
14	into	into	ADP	IN	_	_	_	_	_
15	293T	293t	ADJ	JJ	Degree=Pos	_	_	_	_
16	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
17	fibroblasts	fibroblast	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	Fli	Fli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
25	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	Fli	Fli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	GPIX	GPIX	PROPN	NNP	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	when	when	ADV	WRB	PronType=Int	_	_	_	_
39	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
41	GPIX	Gpix	PROPN	NNP	Number=Sing	_	_	_	_
42	Ets	Et	PROPN	NNPS	Number=Plur	_	_	_	_
43	site	site	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11199
# text = In addition, Fli-1 binding of the GPIX Ets site was identified in antibody supershift experiments in nuclear extracts derived from hematopoietic human erythroleukemia cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GPIX	GPIX	PROPN	NNP	Number=Sing	_	_	_	_
11	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
17	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
18	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
22	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11200
# text = Comparative studies showed that Fli-1 was also able to transactivate the GPIbalpha and, to a lesser extent, the GPIIb promoter.
1	Comparative	Comparative	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	GPIbalpha	GPIbalpha	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
19	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	GPIIb	GPIIb	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11201
# text = Immunoblot analysis identified Fli-1 protein in lysates derived from platelets.
1	Immunoblot	Immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
10	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11202
# text = In addition, expression of Fli-1 was identified immunohistochemically in megakaryocytes derived from CD34(+) cells treated with the megakaryocyte differentiation and proliferation factor, thrombopoietin.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	immunohistochemically	immunohistochemically	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	+)	+)	SYM	NFP	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	megakaryocyte	megakaryocyte	NOUN	NN	Number=Sing	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	thrombopoietin	thrombopoietin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11203
# text = These results suggest that Fli-1 is likely to regulate lineage-specific genes during megakaryocytopoiesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	megakaryocytopoiesis	megakaryocytopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11204
# text = Document 0030012500 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012500	0030012500	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11205
# text = Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells.
1	Aspirin	aspirin	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	stimulated	stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11206
# text = BACKGROUND: The induction of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin by tumor necrosis factor-alpha (TNF) is mediated by mobilization of the transcription factor nuclear factor-kappa B (NF-kappa B).
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	E-	E-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11207
# text = Since salicylates have been reported to inhibit NF-kappa B activation by preventing the degradation of its inhibitor
1	Since	since	SCONJ	IN	_	_	_	_	_
2	salicylates	salicylate	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 11208
# text = I kappa B, we studied a potential inhibition of this pathway by acetylsalicylate (aspirin) in human umbilical vein endothelial cells (HUVECs).
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	acetylsalicylate	acetylsalicylate	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
21	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
22	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11209
# text = METHODS AND RESULTS: Gel-shift analyses demonstrated dose-dependent inhibition of TNF-induced NF-kappa B mobilization by aspirin at concentrations ranging from 1 to 10 mmol/L.
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Gel-	Gel-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	shift	shift	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
26	ranging	range	VERB	VBG	VerbForm=Ger	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	10	10	NUM	CD	NumType=Card	_	_	_	_
31	mmol/	mmol/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
32	L	L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11210
# text = Induction of VCAM-1 and E-selectin surface expression by TNF was dose-dependently reduced by aspirin over the same range, while induction of intercellular adhesion molecule-1 (ICAM-1) was hardly affected.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	dependently	dependently	ADV	RB	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
20	over	over	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
23	range	range	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	while	while	SCONJ	IN	_	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
30	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	X	LS	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	hardly	hardly	ADV	RB	_	_	_	_	_
40	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11211
# text = Aspirin appeared to prevent VCAM-1 transcription, since it dose-dependently inhibited induction of VCAM-1 mRNA by TNF.
1	Aspirin	aspirin	PROPN	NNP	Number=Sing	_	_	_	_
2	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
5	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	since	since	SCONJ	IN	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
12	dose	dose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	-dependently	-dependently	ADV	RB	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11212
# text = As a functional consequence, adhesion of U937 monocytes to TNF-stimulated HUVECs was markedly reduced by aspirin due to suppression of VCAM-1 and E-selectin upregulation.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	U937	U937	NUM	CD	NumType=Card	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	markedly	markedly	ADV	RB	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
20	due	due	ADP	IN	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	VCAM	VCAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	E-	E-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
30	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11213
# text = These effects of aspirin were not related to the inhibition of cyclooxygenase activity, since indomethacin was ineffective.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cyclooxygenase	cyclooxygenase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	since	since	SCONJ	IN	_	_	_	_	_
16	indomethacin	indomethacin	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	ineffective	ineffective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11214
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 11215
# text = Our data suggest that aspirin inhibits NF-kappa B mobilization, induction of VCAM-1 and E-selectin, and subsequent monocyte adhesion in endothelial cells stimulated by TNF, thereby providing an additional mechanism for therapeutic effects of aspirin.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	aspirin	aspirin	ADJ	JJ	Degree=Pos	_	_	_	_
6	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	VCAM	VCAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
24	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	thereby	thereby	ADV	RB	_	_	_	_	_
34	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
37	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
40	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11216
# text = Document 0030012501 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012501	0030012501	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11217
# text = The role of early growth response gene 1 (egr-1) in regulation of the immune response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11218
# text = The induction of immediate early genes in cells of the immune system is critical to determining the ultimate outcome of exposure to antigen.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	SCONJ	IN	_	_	_	_	_
16	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	ultimate	ultimate	ADJ	JJ	Degree=Pos	_	_	_	_
19	outcome	outcome	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11219
# text = The importance of many of these genes relates to the role their transcription factor products play in dictating patterns of expression of downstream, function-related genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	relates	relate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	products	product	NOUN	NNS	Number=Plur	_	_	_	_
16	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	dictating	dictat	ADJ	JJ	Degree=Pos	_	_	_	_
19	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11220
# text = Evidence from several systems indicates that the immediate early gene, egr-1 may be of particular importance in the immune system.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
4	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
5	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
19	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11221
# text = Recently, the egr-1 promoter has been shown to be highly responsive to the diverse biochemical signals generated by antigen and cytokines in cells of the immune system.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	highly	highly	ADV	RB	_	_	_	_	_
13	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
17	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
19	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
29	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11222
# text = Furthermore, an important role for egr-1 in determining the differentiation pathway of myeloid cell precursors has been recently elaborated.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-1	-1	NUM	CD	NumType=Card	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	recently	recently	ADV	RB	_	_	_	_	_
21	elaborated	elaborate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11223
# text = Finally, potential targets of regulation by the zinc-finger transcription factor encoded by egr-1 include the interleukin-2, CD44, ICAM-1, and tumor necrosis factor genes.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
4	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	_
18	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CD44	Cd44	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
32	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11224
# text = The role of egr-1 in regulation of the immune response will be discussed in the context of these recent studies.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	egr	egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	context	context	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
21	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11225
# text = Document 0030012506 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012506	0030012506	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11226
# text = T-cell functional regions of the human IL-3 proximal promoter.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11227
# text = The human interleukin-3 (IL-3) gene is expressed almost exclusively in activated T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	almost	almost	ADV	RB	_	_	_	_	_
15	exclusively	exclusively	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11228
# text = Its expression is regulated at both the transcriptional and post-transcriptional level.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	post	post	X	AFX	_	_	_	_	SpaceAfter=No
11	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11229
# text = We have previously shown that treatment of Jurkat T cells with phytohemaglutinin (PHA) and the phorbol ester, PMA, activated transcription initiation from the IL-3 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	phytohemaglutinin	phytohemaglutinin	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
19	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11230
# text = To define the regions of the gene required for transcription activation, we generated a series of reporter constructs containing different regions of the IL-3 gene 5' and 3' flanking sequences.
1	To	to	PART	TO	_	_	_	_	_
2	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	series	series	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
20	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	'	'	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	'	'	PUNCT	``	_	_	_	_	_
34	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11231
# text = Both positive and negative regulatory elements were identified in the proximal 5' flanking region of the IL-3 gene.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	_
14	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11232
# text = The promoter region between -173 and -60 contained the strongest activating elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	173	173	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	60	60	NUM	CD	NumType=Card	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	strongest	strongest	ADJ	JJS	Degree=Sup	_	_	_	_
13	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
14	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11233
# text = The transcription factor AP-1 could bind to this positive activator region of the promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11234
# text = We also examined the function of the IL-3 CK-1/CK-2 elements that are present in many cytokine genes and found that they acted as a repressor of basal level expression when cloned upstream of a heterologous promoter but were also inducible by PMA/PHA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-1/CK	-1/ck	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
27	acted	act	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
33	level	level	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	when	when	ADV	WRB	PronType=Int	_	_	_	_
36	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
41	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
42	but	but	CCONJ	CC	_	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	also	also	ADV	RB	_	_	_	_	_
45	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
49	PHA.	PHA.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11235
# text = Document 0030012512 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012512	0030012512	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11236
# text = Negative regulation of human immunodeficiency virus type 1 expression in monocytes: role of the 65-kDa plus 50-kDa NF-kappa B dimer.
1	Negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
19	plus	plus	CCONJ	CC	_	_	_	_	_
20	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11237
# text = Although monocytic cells can provide a reservoir for viral production in vivo, their regulation of human immunodeficiency virus type 1 (HIV-1) transcription can be either latent, restricted, or productive.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	either	either	ADV	RB	_	_	_	_	_
31	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11238
# text = These differences in gene expression have not been molecularly defined.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	molecularly	molecularly	ADV	RB	_	_	_	_	_
10	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11239
# text = In THP-1 cells with restricted HIV expression, there is an absence of DNA-protein binding complex formation with the HIV-1 promoter-enhancer associated with markedly less viral RNA production.
1	In	in	ADP	IN	_	_	_	_	_
2	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	there	there	PRON	EX	_	_	_	_	_
12	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
21	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	markedly	markedly	ADV	RB	_	_	_	_	_
33	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
34	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
35	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11240
# text = This absence of binding was localized to the NF-kappa B region of the HIV-1 enhancer; the 65-kDa plus 50-kDa NF-kappa B heterodimer was preferentially lost.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	SCONJ	IN	_	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
25	plus	plus	CCONJ	CC	_	_	_	_	_
26	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	preferentially	preferentially	ADV	RB	_	_	_	_	_
36	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11241
# text = Adding purified NF-kappa B protein to nuclear extracts from cells with restricted expression overcomes this lack of binding.
1	Adding	add	AUX	VBG	VerbForm=Ger	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	overcomes	overcome	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11242
# text = In addition, treatment of these nuclear extracts with sodium deoxycholate restored their ability to form the heterodimer, suggesting the presence of an inhibitor of NF-kappa B activity.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
11	deoxycholate	deoxycholate	NOUN	NN	Number=Sing	_	_	_	_
12	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11243
# text = Furthermore, treatment of nuclear extracts from these cells that had restricted expression with lipopolysaccharide increased viral production and NF-kappa B activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11244
# text = Antiserum specific for NF-kappa B binding proteins, but not c-rel-specific antiserum, disrupted heterodimer complex formation.
1	Antiserum	Antiserum	PROPN	NNP	Number=Sing	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	rel-specific	rel-specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	disrupted	disrupt	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
20	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11245
# text = Thus, both NF-kappa B-binding complexes are needed for optimal viral transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11246
# text = Binding of the 65-kDa plus 50-kDa heterodimer to the HIV-1 enhancer can be negatively regulated in monocytes, providing one mechanism restricting HIV-1 gene expression.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
7	plus	plus	CCONJ	CC	_	_	_	_	_
8	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	negatively	negatively	ADV	RB	_	_	_	_	_
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	providing	provid	VERB	VBG	VerbForm=Ger	_	_	_	_
26	one	one	NUM	CD	NumType=Card	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
28	restricting	restrict	VERB	VBG	VerbForm=Ger	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11247
# text = Document 0030012516 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012516	0030012516	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11248
# text = Cooperation of binding sites for STAT6 and NF kappa B/rel in the IL-4-induced up-regulation of the human IgE germline promoter.
1	Cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	SCONJ	IN	_	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
27	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11249
# text = Ig heavy chain class switching is directed by cytokines inducing transcription from unrearranged CH genes.
1	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
2	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
3	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	unrearranged	unrearrange	ADJ	JJ	Degree=Pos	_	_	_	_
14	CH	Ch	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11250
# text = Subsequently, such primed cells can undergo switch recombination to express the selected new isotype.
1	Subsequently	subsequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
4	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	undergo	undergo	ADV	RB	_	_	_	_	_
8	switch	switch	VERB	VB	VerbForm=Inf	_	_	_	_
9	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
15	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11251
# text = In the case of IgE class switching, IL-4 activates the IgE germline promoter by inducing the interaction of the transcription factor STAT6 (IL-4STAT) with a responsive DNA element in the proximal region of the promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	case	case	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	_
15	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	ADV	RB	_	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4STAT	4stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11252
# text = This study describes the characterization of two additional cis-acting elements that interact with members of the NF kappa B/rel transcription factor family in an IL-4-independent fashion.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	describes	describe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	members	member	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
33	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11253
# text = Electrophoretic mobility shift assays show that the nucleoprotein complex formed on the upstream site (NF kappa B1) contains the classical p50/p65 heterodimer.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nucleoprotein	nucleoprotein	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B1	B1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	p65	p65	NUM	CD	NumType=Card	_	_	_	_
26	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11254
# text = The complex on the proximal site (NF kappa B2) appears to be composed of p50 and relB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B2	b2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	relB	relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11255
# text = IgE germline promoter reporter gene constructs carrying point mutations in the NF kappa B2 site were largely unresponsive to IL-4 stimulation in transient transfection experiments, while plasmids with similar mutations in the NF kappa B1 site responded to cytokine stimulation better than the wild-type promoter.
1	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
2	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
8	point	point	NOUN	NN	Number=Sing	_	_	_	_
9	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B2	B2	NUM	CD	NumType=Card	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	largely	largely	ADV	RB	_	_	_	_	_
18	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
26	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
27	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
33	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	_
40	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
43	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
44	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
45	than	than	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	type	type	NOUN	NN	Number=Sing	_	_	_	_
50	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11256
# text = The NF kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 11257
# text = B2 effect was dependent on the presence of the STAT6 binding site, demonstrating that the NF kappa B2 motif is necessary but not sufficient for mediating cytokine up-regulation.
1	B2	B2	NUM	CD	NumType=Card	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	STAT6	Stat6	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B2	b2	NUM	CD	NumType=Card	_	_	_	_
20	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	cytokine	cytokine	PRON	PRP	_	_	_	_	_
29	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11258
# text = In addition, the combination of a NF kappa B/rel binding site and the STAT6 response element conferred IL-4 inducibility to a heterologous minimal promoter, while the individual sites had no effect.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	rel	rel	X	FW	Foreign=Yes	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
28	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	while	while	SCONJ	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	no	no	DET	DT	_	_	_	_	_
37	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11259
# text = The available data suggest that the NF kappa B2 nucleoprotein complex may cooperate with DNA-bound STAT6 to achieve IL-4-dependent activation of the human IgE germline gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B2	B2	NUM	CD	NumType=Card	_	_	_	_
10	nucleoprotein	nucleoprotein	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
18	STAT6	Stat6	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	achieve	achieve	VERB	VB	VerbForm=Inf	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
31	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11260
# text = Document 0030012522 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012522	0030012522	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11261
# text = Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
4	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
5	+	+	SYM	SYM	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-mediated	-mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11262
# text = To elucidate the role of retinoic acid (RA) in anti-CD40 + interleukin-4 (IL-4)-mediated B-cell activation, the effect of 10(-12) to 10(-6) mol/L RA was studied in anti-CD40 (1 microgram/mL) + IL-4 (5 ng/mL)-mediated proliferation and Ig synthesis by human peripheral blood mononuclear cells (PBMC) and B cells in healthy donors.
1	To	to	PART	TO	_	_	_	_	_
2	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	_
13	+	+	SYM	SYM	_	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	(-12	(-12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
37	6	6	X	LS	_	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	mol/	molith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
40	L	L	PROPN	NNP	Number=Sing	_	_	_	_
41	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	microgram/	microgram/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	mL	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	+	+	SYM	SYM	_	_	_	_	_
52	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
54	4	4	NUM	CD	NumType=Card	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	5	5	NUM	CD	NumType=Card	_	_	_	_
57	ng/mL	ng/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	-mediated	-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
60	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
63	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
64	by	by	ADP	IN	_	_	_	_	_
65	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
66	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
67	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
68	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
69	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
70	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
71	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	)	)	PUNCT	-RRB-	_	_	_	_	_
73	and	and	CCONJ	CC	_	_	_	_	_
74	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
75	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
76	in	in	ADP	IN	_	_	_	_	_
77	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
78	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11263
# text = Anti-CD40 +
1	Anti-CD40	Anti-CD40	NUM	CD	NumType=Card	_	_	_	_
2	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 11264
# text = IL-4-mediated proliferation of PBMC and B cells was inhibited by RA in a dose-dependent manner, with maximal inhibition of 62% +/-
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	62	62	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	%	%	SYM	NN	Number=Sing	_	_	_	_
29	+/-	+/-	SYM	NFP	_	_	_	_	_

# sent_id = 11265
# text = 5% in PBMC and 55%
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	%	%	SYM	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	55	55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	%	%	SYM	NN	Number=Sing	_	_	_	_

# sent_id = 11266
# text = +/- 4.4% in B cells by all-trans RA, and 58% +/- 6.7% and 51% +/- 4.7%, respectively by 13-cis RA.
1	+/-	+/-	SYM	NFP	_	_	_	_	_
2	4.4	4.4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	%	%	SYM	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
11	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	58	58	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	%	%	SYM	NN	Number=Sing	_	_	_	_
16	+/-	+/-	SYM	SYM	_	_	_	_	_
17	6.7	6.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	51	51	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	+/-	+/-	SYM	SYM	_	_	_	_	_
23	4.7	4.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
31	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11267
# text = IgE synthesis was even more markedly inhibited by RA starting at concentrations of >10(-14) mol/L for B cells and >10(-10) mol/L for PBMC.
1	IgE	Ige	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	synthesis	synthesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	even	even	ADV	RB	_	_	_	_	_
5	more	more	ADV	RBR	_	_	_	_	_
6	markedly	markedly	ADV	RB	_	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
10	starting	start	VERB	VBG	VerbForm=Ger	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	>10(-14	>10(-14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	>10(-10	>10(-10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11268
# text = Maximal inhibition of IgE production for B cells was at 10(-8) mol/L for all-trans RA (94% +/- 1.8%) and 96% +/- 3.2% for 13-cis RA.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
13	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	all	all	DET	DT	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	trans	trans	NOUN	NNS	Number=Plur	_	_	_	_
20	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	94	94	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	%	%	SYM	NN	Number=Sing	_	_	_	_
24	+/-	+/-	SYM	SYM	_	_	_	_	_
25	1.8	1.8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	96	96	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	%	%	SYM	NN	Number=Sing	_	_	_	_
31	+/-	+/-	SYM	SYM	_	_	_	_	_
32	3.2	3.2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
37	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
38	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11269
# text = Low concentrations of RA inhibiting IgE synthesis (10(-10) mol/L) affected neither B-cell proliferation nor the production of IgA, IgG, and IgM.
1	Low	low	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
6	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
7	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
11	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	neither	neither	DET	DT	_	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	nor	nor	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IgA	IgA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	IgM	IgM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11270
# text = Elucidation of the mechanism involved in this inhibition of IgE production shows that epsilon germline transcription is decreased by RA, whereas production of interferon-gamma (IFN-gamma) was not enhanced in the presence of RA.
1	Elucidation	Elucidation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
15	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	whereas	SCONJ	IN	_	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11271
# text = To differentiate whether the RA effect was mediated by RA receptors alpha, beta, and gamma, the expression of the retinoic acid receptors (RAR) was examined by reverse transcriptase-polymerase chain reaction (RT-PCR).
1	To	to	PART	TO	_	_	_	_	_
2	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
24	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
33	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
36	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
37	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	RT-PCR	RT-PCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11272
# text = The data show that unstimulated human peripheral B cells express mRNA of the RA receptor alpha, beta, and gamma.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11273
# text = Using retinoids with different receptor binding specificity (CD336, CD437, CD2019, CD367), dose-dependent inhibition of IgE synthesis was shown by all four derivates, but was most marked by an RA binding the alpha receptor with high specificity.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
7	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	CD336	CD336	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CD437	CD437	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	CD2019	Cd2019	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	CD367	CD367	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	_
24	synthesis	synthesis	PROPN	NNP	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	all	all	DET	DT	_	_	_	_	_
29	four	four	NUM	CD	NumType=Card	_	_	_	_
30	derivates	derivate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	most	most	ADV	RBS	_	_	_	_	_
35	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
45	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11274
# text = Taken together, this study shows that RA inhibits
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
9	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_

# sent_id = 11275
# text = IgE production of anti-CD40 + IL-4-stimulated B cells in vitro.
1	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	anti-CD40	anti-CD40	NUM	CD	NumType=Card	_	_	_	_
5	+	+	SYM	SYM	_	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11276
# text = Copyright 1998 by The American Society of Hematology.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1998	1998	NUM	CD	NumType=Card	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	American	american	ADJ	JJ	Degree=Pos	_	_	_	_
6	Society	Society	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Hematology	Hematology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11277
# text = Document 0030012523 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012523	0030012523	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11278
# text = Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.
1	Interferons	Interferon	NOUN	NNS	Number=Plur	_	_	_	_
2	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	interleukin	interleukin	ADV	RB	_	_	_	_	_
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
14	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11279
# text = Interferons (IFNs) inhibit induction by IL-4 of multiple genes in human monocytes.
1	Interferons	Interferon	NOUN	NNS	Number=Plur	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IFNs	IFNs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11280
# text = However, the mechanism by which IFNs mediate this inhibition has not been defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	IFNs	IFNs	PROPN	NNPS	Number=Plur	_	_	_	_
8	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11281
# text = IL-4 activates gene expression by inducing tyrosine phosphorylation, homodimerization, and nuclear translocation of the latent transcription factor, STAT6 (signal transducer and activator of transcription-6).
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
5	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	homodimerization	homodimerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	STAT6	Stat6	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11282
# text = STAT6-responsive elements are characteristically present in the promoters of IL-4-inducible genes.
1	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-responsive	-responsive	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	characteristically	characteristically	ADV	RB	_	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11283
# text = Because STAT6 activation is essential for IL-4-induced gene expression, we examined the ability of type I and type II IFNs to regulate activation of STAT6 by IL-4 in primary human monocytes.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	IFNs	IFN	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	4	4	NUM	CD	NumType=Card	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11284
# text = Pretreatment of monocytes with IFN-beta or IFN-gamma, but not IL-1, IL-2, macrophage colony-stimulating factor, granulocyte/macrophage colony-stimulating factor, IL-6, or transforming growth factor beta suppressed activation of STAT6 by IL-4.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
32	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
43	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	beta	beof	NOUN	NN	Number=Sing	_	_	_	_
46	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11285
# text = This inhibition was associated with decreased tyrosine phosphorylation and nuclear translocation of STAT6 and was not evident unless the cells were preincubated with IFN for at least 1 hr before IL-4 stimulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
18	unless	unless	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	at	at	ADV	RB	_	_	_	_	_
27	least	least	ADV	RBS	Degree=Sup	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
30	before	before	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11286
# text = Furthermore, inhibition by IFN could be blocked by cotreatment with actinomycin D and correlated temporally with induction of the JAK/STAT inhibitory gene, SOCS-1.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing|Typo=Yes	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cotreatment	cotreatment	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	actinomycin	actinomycin	NOUN	NN	Number=Sing	_	_	_	_
13	D	d	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	temporally	temporally	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
24	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	SOCS	SOCS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11287
# text = Forced expression of SOCS-1 in a macrophage cell line, RAW264, markedly suppressed trans-activation of an IL-4-inducible reporter as well as IL-6- and IFN-gamma-induced reporter gene activity.
1	Forced	forced	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	RAW264	RAW264	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	markedly	markedly	ADV	RB	_	_	_	_	_
16	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
27	as	as	ADV	RB	_	_	_	_	_
28	well	well	ADV	RB	Degree=Pos	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-gamma	-gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11288
# text = These findings demonstrate that IFNs inhibit IL-4-induced activation of STAT6 and STAT6-dependent gene expression, at least in part, by inducing expression of SOCS-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IFNs	IFNs	PROPN	NNPS	Number=Plur	_	_	_	_
6	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT6	Stat6	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	STAT6	Stat6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	at	at	ADV	RB	_	_	_	_	_
22	least	least	ADV	RBS	Degree=Sup	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	by	by	SCONJ	IN	_	_	_	_	_
27	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11289
# text = Document 0030012536 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012536	0030012536	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11290
# text = Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IkB	IkB	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11291
# text = The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
9	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	target	target	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	synergizes	synergize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11292
# text = We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	s	s	X	AFX	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
24	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11293
# text = While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B.
1	While	while	SCONJ	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	U937	U937	NUM	CD	NumType=Card	_	_	_	_
17	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11294
# text = Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation.
1	Having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+)	+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	accelerating	accelerat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	IkB	IkB	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	focused	focus	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	IkB	Ikb	PROPN	NNP	Number=Sing	_	_	_	_
31	alpha	alpha	ADP	IN	_	_	_	_	_
32	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11295
# text = While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation.
1	While	while	SCONJ	IN	_	_	_	_	_
2	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
6	sequentially	sequentially	ADV	RB	_	_	_	_	_
7	result	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	incomplete	incomplete	ADJ	JJ	Degree=Pos	_	_	_	_
15	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IkB	Ikb	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	co-activation	co-activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
33	accelerates	accelerate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IkB	Ikb	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	results	result	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
44	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
45	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11296
# text = Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	alone	alone	ADV	RB	_	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	or	or	CCONJ	CC	_	_	_	_	_
20	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IkB	IkB	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	U937	U937	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11297
# text = Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
8	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	GF	gf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	109203X	109203X	PROPN	NNP	Number=Sing	_	_	_	_
12	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 11298
# text = IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus.
1	IkB	Ikb	X	LS	_	_	_	_	_
2	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	irrespective	irrespective	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IkB	Ikb	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
37	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11299
# text = Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation.
1	Contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IkB	Ikb	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	ADP	IN	_	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
35	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11300
# text = These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
16	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	synergize	synergize	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
41	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
42	at	at	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	level	level	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	IkB	Ikb	PROPN	NNP	Number=Sing	_	_	_	_
47	alpha	alpha	ADP	IN	_	_	_	_	_
48	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11301
# text = Document 0030012539 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012539	0030012539	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11302
# text = Protein kinase C is not a downstream effector of p21ras in activated T cells.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11303
# text = The aim of this present study was to investigate the role of protein kinase C (PKC), downstream of p21ras, in activating interleukin-2 (IL-2) gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	C	C	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	in	in	SCONJ	IN	_	_	_	_	_
25	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11304
# text = It has been reported that PKC is an effector of p21ras in T cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11305
# text = Data is presented, using the potent and selective PKC inhibitor Ro 31-8425 and transient expression of a constitutively active ras mutant, which clearly shows that PKC is not downstream of p21ras in the induction of NF-AT and AP-1 transcriptional activity and in the expression of IL-2 in human Jurkat T cells.
1	Data	data	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	presented	present	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
10	PKC	Pkc	PROPN	NNP	Number=Sing	_	_	_	_
11	inhibitor	inhibitor	ADP	IN	_	_	_	_	_
12	Ro	Ro	PROPN	NNP	Number=Sing	_	_	_	_
13	31-	31-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	8425	8425	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	constitutively	constitutively	ADV	RB	_	_	_	_	_
21	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
22	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
23	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	clearly	clearly	ADV	RB	_	_	_	_	_
27	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	2	2	NUM	CD	NumType=Card	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
58	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
59	T	t	PROPN	NNP	Number=Sing	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11306
# text = Reporter gene experiments demonstrated that NF-kappa B transcriptional activity is not affected by expression of activated p21ras.
1	Reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11307
# text = The signaling pathways involving PKC activation, calcium mobilization and ras activation combine to provide the necessary components for production of IL-2 during T cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
5	PKC	Pkc	PROPN	NNP	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
9	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	ras	ras	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	combine	combine	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
18	components	component	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	T	t	NUM	CD	NumType=Card	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11308
# text = Document 0030012541 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012541	0030012541	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11309
# text = Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	Mycoplasma	Mycoplasma	PROPN	NNP	Number=Sing	_	_	_	_
25	fermentans	fermentan	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
27	lipoproteins.	lipoprotein.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 11310
# text = Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN).
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	8	8	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	8	8	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	belongs	belong	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	CXC	CXC	PROPN	NNP	Number=Sing	_	_	_	_
21	subfamily	subfamily	ADV	RB	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
28	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	PMN	PMN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11311
# text = IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	8	8	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	notably	notably	ADV	RB	_	_	_	_	_
13	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
14	products	product	NOUN	NNS	Number=Plur	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	about	about	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	mechanisms	mechanisms	NOUN	NNS	Number=Plur	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
33	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	8	8	NUM	CD	NumType=Card	_	_	_	_
37	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11312
# text = In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Mycoplasma	Mycoplasma	PROPN	NNP	Number=Sing	_	_	_	_
9	fermentans	fermentan	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	lipid-associated	lipid-associated	ADJ	JJ	Degree=Pos	_	_	_	_
11	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LAMPf	LAMPf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	8	8	NUM	CD	NumType=Card	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	PMN	Pmn	NOUN	NN	Number=Sing	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
40	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11313
# text = It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	LAMPf	LAMPf	PROPN	NNP	Number=Sing	_	_	_	_
15	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	series	series	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
21	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
22	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
23	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
31	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11314
# text = By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	PD	PD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	98059	98059	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	SB	Sb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	203580	203580	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	MEK1	MEK1	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	1/2	1/2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p38	p38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
31	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	both	both	DET	DT	_	_	_	_	_
35	ERK	ERK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	1/	1/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	p38	p38	NUM	CD	NumType=Card	_	_	_	_
40	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
41	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
44	role	role	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	production	production	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	8	8	NUM	CD	NumType=Card	_	_	_	_
52	by	by	ADP	IN	_	_	_	_	_
53	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	PMN	Pmn	NOUN	NN	Number=Sing	_	_	_	_
56	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	with	with	ADP	IN	_	_	_	_	_
58	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
59	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11315
# text = Document 0030012543 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012543	0030012543	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11316
# text = Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	allergies	allergy	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11317
# text = Interleukin-10 (IL-10) and transforming growth factor beta (TGF-beta) are inhibitory for B and T cells, IgE production, and mast cell proliferation, and they induce apoptosis in eosinophils.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-10	-10	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	mast	mast	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
36	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11318
# text = These cytokines are therefore candidate genes which could contribute to the development of asthma or allergies.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	therefore	therefore	ADV	RB	_	_	_	_	_
5	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	development	development	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	allergies	allergy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11319
# text = We investigated the hypothesis that polymorphic nucleotides within the IL-10 and TGF-beta gene promoters would link to the expression of allergies and asthma.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
7	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
19	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
20	link	link	VERB	VB	VerbForm=Inf	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	allergies	allergy	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11320
# text = DNA taken from families with an asthmatic proband was examined for base exchanges by single-stranded conformational polymorphism (SSCP).
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	families	family	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	asthmatic	asthmatic	ADJ	JJ	Degree=Pos	_	_	_	_
8	proband	proband	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	base	base	NOUN	NN	Number=Sing	_	_	_	_
13	exchanges	exchange	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	conformational	conformational	ADJ	JJ	Degree=Pos	_	_	_	_
19	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	SSCP	SSCP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11321
# text = We demonstrated the presence of a polymorphism in the promoter region of the IL-10 gene and four in the TGF-beta gene promoters (3 in TGF-beta1 and 1 in TGF-beta2).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	four	four	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	3	3	NUM	CD	NumType=Card	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	beta2	beta2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11322
# text = The IL-10 gene polymorphism was a C-to-A exchange 571 base pairs upstream from the translation start site and was present between consensus binding sequences for Sp1 and elevated total serum.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	A	a	NOUN	NN	Number=Sing	_	_	_	_
14	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
15	571	571	NUM	CD	NumType=Card	_	_	_	_
16	base	base	NOUN	NN	Number=Sing	_	_	_	_
17	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
18	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
22	start	start	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
27	between	between	ADP	IN	_	_	_	_	_
28	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
36	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11323
# text = This polymorphism was associated with elevated total serum IgE in subjects heterozygotic or homozygotic for this base exchange (p < 0.009).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
8	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
9	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
12	heterozygotic	heterozygotic	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	homozygotic	homozygotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	base	base	NOUN	NN	Number=Sing	_	_	_	_
18	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	p	p	NOUN	NN	Number=Sing	_	_	_	_
21	<	<	PUNCT	-LRB-	_	_	_	_	_
22	0.009	0.009	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11324
# text = The base exchange at -509 (from the transcription initiation site) in the TGF-beta promoter also linked to elevated total IgE (p < 0.01).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	base	base	NOUN	NN	Number=Sing	_	_	_	_
3	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	509	509	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	from	from	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
25	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	p	p	NOUN	NN	Number=Sing	_	_	_	_
28	<	<	PUNCT	-LRB-	_	_	_	_	_
29	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11325
# text = This polymorphism represented a C-to-T base exchange which induced a YY1 consensus sequence and is present in a region of the promoter associated with negative transcription regulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
3	represented	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	to	to	PART	TO	_	_	_	_	SpaceAfter=No
8	-T	-t	VERB	VB	VerbForm=Inf	_	_	_	_
9	base	base	NOUN	NN	Number=Sing	_	_	_	_
10	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	YY1	YY1	NUM	CD	NumType=Card	_	_	_	_
15	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11326
# text = Document 0030012546 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012546	0030012546	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11327
# text = Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFAT4	NFAT4	PROPN	NNP	Number=Sing	_	_	_	_
5	opposed	oppose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11328
# text = The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T	T	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	group	group	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11329
# text = NFAT activation is mediated in part by induced nuclear import.
1	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	part	part	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	import	import	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11330
# text = This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	process	process	NOUN	NN	Number=Sing	_	_	_	_
3	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
10	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
14	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11331
# text = The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
5	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	phosphorylates	phosphorylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	NFAT4	NFAT4	NUM	CD	NumType=Card	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11332
# text = Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NFAT4	NFAT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11333
# text = In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	calcineurin-	calcineurin-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	exclusion	exclusion	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFAT4	NFAT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11334
# text = These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NFAT4	NFAT4	PROPN	NNP	Number=Sing	_	_	_	_
10	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	opposed	oppose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11335
# text = Document 0030012547 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012547	0030012547	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11336
# text = Stimulation of neutrophil interleukin-8 production by eosinophil granule major basic protein.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	8	8	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	_
10	granule	granule	NOUN	NN	Number=Sing	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11337
# text = We evaluated the ability of eosinophil granule major basic protein (MBP) to stimulate interleukin (IL)-8 production by neutrophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	_
7	granule	granule	NOUN	NN	Number=Sing	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	8	8	NUM	CD	NumType=Card	_	_	_	_
22	production	production	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11338
# text = MBP over the concentration range of 0.1 to 10 microM stimulated the release of up to approximately 8 ng/ml IL-8.
1	MBP	MBp	SYM	NFP	_	_	_	_	_
2	over	over	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
5	range	range	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	0.1	0.1	NUM	CD	NumType=Card	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	microM	microM	PROPN	NNP	Number=Sing	_	_	_	_
11	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	release	release	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	up	up	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	8	8	NUM	CD	NumType=Card	_	_	_	_
19	ng/	ngith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
20	ml	ml	PROPN	NNP	Number=Sing	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11339
# text = Incubation with 2 microM MBP showed that, after a 1 h lag, the level of IL-8 release increased with time for approximately 10 h.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	microM	microm	PROPN	NNP	Number=Sing	_	_	_	_
5	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	_
13	lag	lag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	8	8	NUM	CD	NumType=Card	_	_	_	_
21	release	release	NOUN	NN	Number=Sing	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	approximately	approximately	ADV	RB	_	_	_	_	_
27	10	10	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11340
# text = At the 2 microM concentration, eosinophil cationic protein, eosinophil-derived neurotoxin, and eosinophil peroxidase did not stimulate significant levels of IL-8 production.
1	At	at	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
5	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	eosinophil	eosinophil	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
8	cationic	cationic	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	neurotoxin	neurotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	_
18	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
22	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	8	8	NUM	CD	NumType=Card	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11341
# text = MBP stimulated 2-fold increases in IL-8 messenger RNA (mRNA) after 1 and 3
1	MBP	MBp	SYM	NFP	_	_	_	_	_
2	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
6	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
12	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 11342
# text = h of incubation, which were blocked by pretreatment with actinomycin D.
1	h	h	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	actinomycin	actinomycin	ADP	IN	_	_	_	_	_
12	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11343
# text = However, stimulation with MBP did not produce an increase in the binding activity of nuclear factor (NF)-kappaB or activator protein-1.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	_
6	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11344
# text = No NF-IL-6 binding activity was detected in the same nuclear extracts.
1	No	no	DET	DT	_	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11345
# text = In addition, stimulation with MBP prolonged the stability of IL-8 mRNA.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	_
7	prolonged	prolong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	PROPN	NNP	Number=Sing	_	_	_	_
14	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11346
# text = MBP also induced transient increases in mRNA for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta, but did not stimulate the release of either chemokine.
1	MBP	MBp	SYM	NFP	_	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
5	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MIP	MIP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	MIP	Mip	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	release	release	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	either	either	DET	DT	_	_	_	_	_
30	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11347
# text = These findings indicate that MBP is selective among the eosinophil granule proteins as a stimulus for neutrophil IL-8 release and, further, that stimulation of neutrophil IL-8 release by MBP involves both transcriptional and posttranscriptional regulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
8	among	among	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	_
11	granule	granule	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	8	8	NUM	CD	NumType=Card	_	_	_	_
21	release	release	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	further	further	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	8	8	NUM	CD	NumType=Card	_	_	_	_
33	release	release	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	_
36	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
37	both	both	CCONJ	CC	_	_	_	_	_
38	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
41	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11348
# text = We postulate that MBP-induced release of IL-8 by neutrophils may contribute to the pathophysiology of acute asthma and other inflammatory lung diseases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	postulate	postulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	MBP	Mbp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	release	release	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	8	8	NUM	CD	NumType=Card	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pathophysiology	pathophysiology	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
21	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
26	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11349
# text = Document 0030012555 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012555	0030012555	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11350
# text = Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
20	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	:	:	PUNCT	:	_	_	_	_	_
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	16	16	NUM	CD	NumType=Card	_	_	_	_
27	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11351
# text = The putative factors that couple the signal transduction from surface receptors to the activation of cytokine synthesis in natural killer (NK) cells have not been elucidated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	couple	couple	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
20	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11352
# text = We report here that the nuclear factor of activated T cells (NFATp), a cyclosporin A (CsA)-sensitive factor that regulates the transcription of several cytokines, mediates CD16-induced activation of cytokine genes in human NK cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
18	A	a	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	CD16	CD16	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-induced	-induced	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
39	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11353
# text = CD16 (Fc gamma RIIIA)-induced expression of cytokine mRNA in NK cells occurs via a CsA-sensitive and Ca(2+)-dependent mechanism.
1	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	16	16	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
5	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
6	RIIIA	RIIIA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11354
# text = Stimulation of NK cells with CD16 ligands induces NFAT-like DNA binding activity in the nuclear extracts from these cells, as detected in electrophoretic mobility shift assays.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	16	16	NUM	CD	NumType=Card	_	_	_	_
8	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
9	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
10	NFAT	NFAT	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
28	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
29	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
30	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11355
# text = This occurs with fast kinetics after stimulation, via a CsA-sensitive and Ca(2+)-dependent mechanism that does not require de novo protein synthesis.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	_
5	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
6	after	after	ADP	IN	_	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	via	via	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
26	de	de	NOUN	NN	Number=Sing	_	_	_	_
27	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11356
# text = NK cell NFAT is present in the cytosol of nonstimulated cells, migrates to the nucleus upon stimulation, and can associate with AP-1.
1	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
3	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nonstimulated	nonstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	migrates	migrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
17	upon	upon	ADP	IN	_	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11357
# text = Two distinct molecules, NFATp and NFATc, have been reported to mediate NFAT activity.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
14	NFAT	NFAT	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11358
# text = The results of supershift assays using NFATp- and NFATc- specific antibodies indicate that NK cell activation early after CD16 ligand binding involves primarily, if not exclusively, NFATp, and Western blot analysis shows that this has the same electrophoretic mobility (approximately 120 kD) as that of T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
14	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	early	early	ADV	RB	Degree=Pos	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	16	16	NUM	CD	NumType=Card	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
26	primarily	primarily	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	if	if	SCONJ	IN	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	exclusively	exclusively	ADV	RB	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
36	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
37	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
38	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	that	that	SCONJ	IN	_	_	_	_	_
40	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
41	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
44	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
45	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	approximately	approximately	ADV	RB	_	_	_	_	_
48	120	120	NUM	CD	NumType=Card	_	_	_	_
49	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	as	as	ADP	IN	_	_	_	_	_
52	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11359
# text = NK cells do not express NFATc constitutively, but NFATc mRNA accumulation is induced in these cells within 2 h of stimulation with CD16 ligands.
1	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
6	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	h	h	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	16	16	NUM	CD	NumType=Card	_	_	_	_
26	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11360
# text = However, supershift assays using the available mAb recognizing the T cell NFATc revealed no detectable NFATc protein in nuclear and cytoplasmic extracts from CD16- or phorbol ester-stimulated cells at any time tested, up to 4 h.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	supershift	supershift	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
8	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
9	recognizing	recognize	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
13	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
14	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
17	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
23	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	CD16	CD16	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
29	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	any	any	DET	DT	_	_	_	_	_
35	time	time	NOUN	NN	Number=Sing	_	_	_	_
36	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	up	up	ADP	IN	_	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	4	4	NUM	CD	NumType=Card	_	_	_	_
41	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11361
# text = These results provide the first direct evidence that both CsA-sensitive transcription factors, NFATp and NFATc, are expressed in human NK cells, and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells, results in early activation of NFATp and subsequently induced expression of NFATc mRNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADV	RBS	_	_	_	_	_
6	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	or	or	CCONJ	CC	_	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
44	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	case	case	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	CD16	CD16	PROPN	NNP	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
55	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	results	result	NOUN	NNS	Number=Plur	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
60	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	subsequently	subsequently	ADV	RB	_	_	_	_	_
65	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
66	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	_
69	mRNA.	mRNA.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11362
# text = Document 0030012565 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012565	0030012565	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11363
# text = Overexpression of protein kinase C-zeta stimulates leukemic cell differentiation.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
7	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11364
# text = A function for protein kinase C-zeta (PKC-zeta), a member of the phorbol ester nonresponsive atypical protein kinase C subfamily, in modulating differentiation was examined in the leukemic U937 cell.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	member	member	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
21	nonresponsive	nonresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
22	atypical	atypical	ADJ	JJ	Degree=Pos	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	C	C	PROPN	NNP	Number=Sing	_	_	_	_
26	subfamily	subfamily	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	modulating	modulat	ADJ	JJ	Degree=Pos	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
36	U937	U937	NUM	CD	NumType=Card	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11365
# text = Transfected U937 cells stably overexpressing PKC-zeta displayed a longer doubling time, lower saturation density at confluency, and an increase in adherence to plastic as compared to control cells.
1	Transfected	Transfect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	U937	U937	NUM	CD	NumType=Card	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	stably	stably	ADV	RB	_	_	_	_	_
5	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
6	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	zeta	zeta	PROPN	NNP	Number=Sing	_	_	_	_
9	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	longer	longer	ADJ	JJR	Degree=Cmp	_	_	_	_
12	doubling	doubling	NOUN	NN	Number=Sing	_	_	_	_
13	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
16	saturation	saturation	NOUN	NN	Number=Sing	_	_	_	_
17	density	density	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	confluency	confluency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	SCONJ	IN	_	_	_	_	_
29	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11366
# text = PKC-zeta cells expressed a more differentiated phenotype as assessed by changes in morphology, surface antigen expression, and lysosomal enzyme activities and were distinct from parental U937 cells stimulated to differentiate by exposure to phorbol esters.
1	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	differentiated	differentiated	ADJ	JJ	Degree=Pos	_	_	_	_
9	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
18	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
23	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
24	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
30	U937	U937	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
39	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11367
# text = In contrast to parental U937 cells, PKC-zeta cells constitutively expressed mRNA transcripts for c-jun and a low mobility AP-1 binding activity.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	parental	parental	VERB	VB	VerbForm=Inf	_	_	_	_
5	U937	U937	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	constitutively	constitutively	ADV	RB	_	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11368
# text = Thus, PKC-zeta overexpression stimulates a type of phenotypic differentiation that differs significantly from maturation occurring upon activation of other PKC subfamilies induced by phorbol ester treatment.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
6	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
7	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	differs	differ	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
18	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
19	upon	upon	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
24	subfamilies	subfamily	NOUN	NNS	Number=Plur	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
28	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
29	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11369
# text = Increased expression of the c-jun protooncogene and an increase in AP-1 binding activity in PKC-zeta cells provides a potential mechanism for explaining the altered differentiation status of this cell.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
7	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	explaining	explain	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
31	status	status	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11370
# text = Document 0030012569 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012569	0030012569	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11371
# text = Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11372
# text = Numerous genes required during the immune or inflammation response as well as the adhesion process are regulated by nuclear factor kappaB (NF-kappaB).
1	Numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	during	during	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	immune	immune	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	process	process	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11373
# text = Associated with its inhibitor, I kappaB, NF-kappaB resides as an inactive form in the cytoplasm.
1	Associated	associate	VERB	VBN	Tense=Past|Typo=Yes|VerbForm=Part|Voice=Pass	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	resides	reside	NOUN	NNS	Number=Plur	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11374
# text = Upon stimulation by various agents, I kappaB is proteolyzed and NF-kappaB translocates to the nucleus, where it activates its target genes.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
5	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	proteolyzed	proteolyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	translocates	translocate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	where	where	ADV	WRB	PronType=Rel	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11375
# text = The transduction pathways that lead to I kappaB inactivation remain poorly understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	SCONJ	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappaB	kappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
10	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	poorly	poorly	ADJ	JJ	Degree=Pos	_	_	_	_
12	understood	understand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11376
# text = In this study, we have characterized a cellular mutant, the 70/Z3-derived 1.3E2 murine pre-B cell line, that does not activate NF-kappaB in response to several stimuli.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	70/Z3	70/Z3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	1.3E2	1.3E2	NUM	CD	NumType=Card	_	_	_	_
17	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
18	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
19	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
24	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
34	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11377
# text = We demonstrate that upon stimulation by lipopolysaccharide, Taxol, phorbol myristate acetate, interleukin-1, or double-stranded RNA, I kappaB alpha is not degraded, as a result of an absence of induced phosphorylation on serines 32 and 36.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	upon	upon	ADP	IN	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Taxol	Taxol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
12	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
13	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	result	result	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
41	on	on	ADP	IN	_	_	_	_	_
42	serines	serine	NOUN	NNS	Number=Plur	_	_	_	_
43	32	32	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11378
# text = Neither a mutation in I kappaB alpha nor a mutation in p50 or relA, the two major subunits of NF-kappaB in this cell line, accounts for this phosphorylation defect.
1	Neither	neither	CCONJ	CC	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
8	nor	nor	CCONJ	CC	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	p50	p50	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	relA	relA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	accounts	account	NOUN	NNS	Number=Plur	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
33	defect	defect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11379
# text = As well as culminating in the inducible phosphorylation of I kappaB alpha on serines 32 and 36, all the stimuli that are inactive on 1.3E2 cells exhibit a sensitivity to the antioxidant pyrrolidine dithiocarbamate (PDTC).
1	As	as	ADV	RB	_	_	_	_	_
2	well	well	ADV	RB	Degree=Pos	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	culminating	culminat	VERB	VBG	VerbForm=Ger	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	ADV	RB	_	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	serines	serine	NOUN	NNS	Number=Plur	_	_	_	_
15	32	32	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	all	all	DET	PDT	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	1.3E2	1.3E2	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	exhibit	exhibit	NOUN	NN	Number=Sing	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
34	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
35	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11380
# text = In contrast, stimuli such as hyperosmotic shock or phosphatase inhibitors, which use PDTC-insensitive pathways, induce I kappaB alpha degradation in 1.3E2.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	stimuli	stimuli	ADJ	JJ	Degree=Pos	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	hyperosmotic	hyperosmotic	ADJ	JJ	Degree=Pos	_	_	_	_
8	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	PDTC	Pdtc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	induce	induce	SCONJ	IN	_	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappaB	kappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	alpha	alpha	ADP	IN	_	_	_	_	_
24	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	1.3E2	1.3E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11381
# text = Analysis of the redox status of 1.3E2 does not reveal any difference from wild-type 70Z/3.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
5	status	status	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	1.3E2	1.3E2	NUM	CD	NumType=Card	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
11	any	any	DET	DT	_	_	_	_	_
12	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	70Z	70z	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11382
# text = We also report that the human T-cell leukemia virus type 1 (HTLV-1)-derived Tax trans-activator induces NF-kappaB activity in 1.3E2, suggesting that this viral protein does not operate via the defective pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
21	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
24	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	1.3E2	1.3E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	operate	operate	VERB	VB	VerbForm=Inf	_	_	_	_
40	via	via	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11383
# text = Finally, we show that two other I kappaB molecules, I kappaB beta and the recently identified I kappaB epsilon, are not degraded in the 1.3E2 cell line following stimulation.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappaB	kappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappaB	kappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	recently	recently	ADV	RB	_	_	_	_	_
18	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	1.3E2	1.3E2	NUM	CD	NumType=Card	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	line	line	NOUN	NN	Number=Sing	_	_	_	_
31	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
32	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11384
# text = Our results demonstrate that 1.3E2 is a cellular transduction mutant exhibiting a defect in a step that is required by several different stimuli to activate NF-kappaB.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	1.3E2	1.3E2	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
10	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
11	exhibiting	exhibite	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	step	step	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
23	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11385
# text = In addition, this analysis suggests a common step in the signaling pathways that trigger I kappaB alpha, I kappaB beta, and I kappaB epsilon degradation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
9	step	step	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	pathways	pathway	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappaB	kappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappaB	kappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappaB	kappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	epsilon	epsilon	ADP	IN	_	_	_	_	_
28	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11386
# text = Document 0030012570 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012570	0030012570	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11387
# text = RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells.
1	RP1	RP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	member	member	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	adenomatous	adenomatous	ADJ	JJ	Degree=Pos	_	_	_	_
9	polyposis	polyposis	NOUN	NN	Number=Sing	_	_	_	_
10	coli-binding	coli-bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	EB	EB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	like	like	ADP	IN	_	_	_	_	_
15	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	differentially	differentially	ADV	RB	_	_	_	_	_
20	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11388
# text = Cross-linking of the CD3 and CD28 molecules on T lymphocytes represents one of the most effective signals for T lymphocyte activation and triggering of their cytotoxic effector function.
1	Cross	cross	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	linking	linking	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	most	most	ADV	RBS	_	_	_	_	_
18	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
19	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
29	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
30	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11389
# text = To identify genes that are expressed in T cells after stimulation, mRNA from T lymphocytes that had been activated by the simultaneous stimulation of the CD3 and CD28 trigger molecules was transcribed for a differential mRNA display analysis into cDNA and was compared with cDNA from CD28- or CD3-activated or resting lymphocytes.
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
24	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
30	trigger	trigger	ADJ	JJR	Degree=Cmp	_	_	_	_
31	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
37	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
38	display	display	NOUN	NN	Number=Sing	_	_	_	_
39	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
40	into	into	ADP	IN	_	_	_	_	_
41	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
44	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	cDNA	cDNa	PROPN	NNP	Number=Sing	_	_	_	_
47	from	from	ADP	IN	_	_	_	_	_
48	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	_
50	or	or	CCONJ	CC	_	_	_	_	_
51	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	or	or	CCONJ	CC	_	_	_	_	_
55	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
56	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11390
# text = Differential expression was confirmed subsequently by Northern blot analysis.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	subsequently	subsequently	ADV	RB	_	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
8	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
9	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11391
# text = One of the cDNA fragments expressed specifically in CD3- and CD28-activated
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
5	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-activated	-activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_

# sent_id = 11392
# text = T cells was designated RP1.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	RP1	RP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11393
# text = The predictive protein-coding region of RP1 had a significant homology to members of the recently found adenomatous polyposis coli (APC) protein-binding EB1 gene family, which codes for yet unknown protein(s).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predictive	predictive	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RP1	RP1	PROPN	NNP	Number=Sing	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
11	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	members	member	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	recently	recently	ADV	RB	_	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	adenomatous	adenomatous	ADJ	JJ	Degree=Pos	_	_	_	_
19	polyposis	polyposis	NOUN	NN	Number=Sing	_	_	_	_
20	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	APC	APC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	EB1	EB1	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	codes	code	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	yet	yet	ADV	RB	_	_	_	_	_
34	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	s	s	X	AFX	_	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11394
# text = Bacterially expressed RP1 protein revealed specific binding to wild-type but not to mutated APC protein.
1	Bacterially	Bacterially	ADV	RB	_	_	_	_	_
2	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	RP1	Rp1	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	APC	Apc	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11395
# text = The rapid up-regulation of RP1 mRNA in properly activated T cells suggests that this gene might belong to the immediate/early gene family, which controls the signal transduction cascade downstream of the TCR.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
3	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RP1	RP1	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	properly	properly	ADV	RB	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
19	belong	belong	VERB	VB	VerbForm=Inf	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
25	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
32	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
33	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
34	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11396
# text = As the expression level of the RP1 gene in activated T cells and a spectrum of tumor-derived cell lines correlates with the proliferative status of the cells, members of the EB1-like gene family may not only be involved in the tumorigenesis of colorectal cancers but may also play a role in the proliferative control of normal cells.
1	As	as	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	level	level	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	RP1	RP1	PROPN	NNP	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
22	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
26	status	status	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	EB	EB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	family	family	NOUN	NN	Number=Sing	_	_	_	_
40	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
41	not	not	PART	RB	_	_	_	_	_
42	only	only	ADV	RB	_	_	_	_	_
43	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
44	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	tumorigenesis	tumorigenesis	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	colorectal	colorectal	ADJ	JJ	Degree=Pos	_	_	_	_
50	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	_
51	but	but	CCONJ	CC	_	_	_	_	_
52	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
53	also	also	ADV	RB	_	_	_	_	_
54	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
55	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
56	role	role	NOUN	NN	Number=Sing	_	_	_	_
57	in	in	ADP	IN	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
60	control	control	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
63	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11397
# text = Document 0030012571 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012571	0030012571	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11398
# text = Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.
1	Non-steroidal	Non-steroidal	ADJ	JJ	Degree=Pos	_	_	_	_
2	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
4	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
11	HSP70	HSP70	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11399
# text = Recent studies have shown that the non-steroidal anti-inflammatory drugs (NSAIDs) activate heat shock transcription factor (HSF1) from a latent cytoplasmic form to a nuclear, DNA binding state.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	non-steroidal	non-steroidal	ADJ	JJ	Degree=Pos	_	_	_	_
8	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NSAIDs	NSAid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
14	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	HSF1	Hsf1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
24	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
25	form	form	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11400
# text = As HSF1 can function as both an activator of heat shock genes and a repressor of non-heat shock genes such as IL1B and c- fos, we have examined the potential role of HSF1 in the effects of NSAIDs on gene expression in a human monocytic cell line THP-1.
1	As	as	SCONJ	IN	_	_	_	_	_
2	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
11	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	non	non	X	AFX	_	_	_	_	SpaceAfter=No
18	-heat	-heat	ADJ	JJ	Degree=Pos	_	_	_	_
19	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	IL1B	Il1b	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	_
27	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
34	role	role	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	HSF1	HSF1	NUM	CD	NumType=Card	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	NSAIDs	NSAid	NOUN	NNS	Number=Plur	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	line	line	NOUN	NN	Number=Sing	_	_	_	_
51	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11401
# text = We found that two members of the NSAIDs, sodium salicylate and sulindac repress the IL1B promoter to similar degree to heat shock or HSF1 overexpression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	members	member	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NSAIDs	Nsaids	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	sodium	sodium	ADJ	JJ	Degree=Pos	_	_	_	_
11	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	sulindac	sulindac	NOUN	NN	Number=Sing	_	_	_	_
14	repress	repress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL1B	Il1b	PROPN	NNP	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
20	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
23	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	HSF1	Hsf1	NUM	CD	NumType=Card	_	_	_	_
26	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11402
# text = In addition, sodium salicylate and additional NSAIDs used at concentrations that activate HSF1 also inhibited the expression of other monocytic genes (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, ICAM-1) activated by exposure to a pro-inflammatory stimulus (lipopolysaccharide, LPS).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
5	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
8	NSAIDs	NSAid	NOUN	NNS	Number=Plur	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	activate	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
52	to	to	ADP	IN	_	_	_	_	_
53	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
55	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11403
# text = At least in the case of the IL1B promoter, repression did not seem to involve another factor whose activity is affected by the NSAIDs, NFkappaB as the IL1B promoter fragment used in our studies is not NFkappaB responsive and binds specifically to HSF1.
1	At	at	ADV	RB	_	_	_	_	_
2	least	least	ADV	RBS	Degree=Sup	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	case	case	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL1B	IL1B	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	seem	seem	VERB	VB	VerbForm=Inf	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
17	another	another	DET	DT	_	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	NSAIDs	Nsaids	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL1B	Il1b	PROPN	NNP	Number=Sing	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
33	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
36	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	NFkappaB	Nfkappab	ADJ	JJ	Degree=Pos	_	_	_	_
40	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
43	specifically	specifically	ADV	RB	_	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11404
# text = Exposure to NSAIDs had a complex effect on HSP gene expression and while sulindac activated the stress responsive HSP70B promoter, sodium salicylate did not.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	NSAIDs	Nsaids	PROPN	NNP	Number=Sing	_	_	_	_
4	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	HSP	Hsp	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	while	while	SCONJ	IN	_	_	_	_	_
14	sulindac	sulindac	NOUN	NN	Number=Sing	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
18	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
19	HSP70B	Hsp70b	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
23	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
24	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11405
# text = In addition, only a subset of the NSAIDs induced HSP70 mRNA species.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NSAIDs	Nsaids	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	HSP70	HSP70	NUM	CD	NumType=Card	_	_	_	_
12	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
13	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11406
# text = These findings reflect the properties of HSF1 which can be activated to at least two DNA binding forms only one of which activates heat shock promoters and suggest that individual NSAID family members may differentially induce one or other of these forms.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	reflect	reflect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	at	at	ADV	RB	_	_	_	_	_
14	least	least	ADV	RBS	Degree=Sup	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
25	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
31	NSAID	nsaid	NOUN	NN	Number=Sing	_	_	_	_
32	family	family	NOUN	NN	Number=Sing	_	_	_	_
33	members	member	NOUN	NNS	Number=Plur	_	_	_	_
34	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
35	differentially	differentially	ADV	RB	_	_	_	_	_
36	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
37	one	one	NUM	CD	NumType=Card	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	forms	form	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11407
# text = Overall therefore, exposure to NSAIDs leads to a profound switch in gene expression in monocytic cells, with suppression of genes involved in macrophage activation and induction of stress genes and HSF1 appears to play a regulatory role in these effects.
1	Overall	overall	ADV	RB	_	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	exposure	exposure	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	NSAIDs	NSAid	PROPN	NNP	Number=Sing	_	_	_	_
7	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
11	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	HSF1	Hsf1	NOUN	NN	Number=Sing	_	_	_	_
34	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
39	role	role	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11408
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11409
# text = Document 0030012572 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012572	0030012572	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11410
# text = Modulation of mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon).
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
12	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
22	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11411
# text = Human C/EBP epsilon is a newly cloned gene coding for a CCAAT/enhancer binding protein that may be involved in the regulation of myeloid differentiation.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
4	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
5	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	newly	newly	ADV	RB	_	_	_	_	_
9	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	coding	cod	VERB	VBG	VerbForm=Ger	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11412
# text = Our studies showed that levels of C/EBP epsilon mRNA were markedly increased in NB4 cells (promyelocytic leukemia line), because they were induced by 9-cis retinoic acid (9-cis RA) to differentiate towards granulocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
10	epsilon	epsilon	ADP	IN	_	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	markedly	markedly	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	because	because	SCONJ	IN	_	_	_	_	_
25	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
32	retinoic	retinoic	NOUN	NN	Number=Sing	_	_	_	_
33	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
38	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
42	towards	towards	ADP	IN	_	_	_	_	_
43	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11413
# text = Accumulation of C/EBP epsilon mRNA occurred as early as 1 hour after exposure of NB4 cells to 9-cis RA (5 x 10(-7) mol/L); and at 48 hours, levels were increased by 5.1-fold.
1	Accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
6	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	as	as	ADV	RB	_	_	_	_	_
10	early	early	ADV	RB	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
23	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	x	x	SYM	SYM	_	_	_	_	_
27	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
29	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	;	;	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	48	48	NUM	CD	NumType=Card	_	_	_	_
37	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	5.1	5.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11414
# text = Dose-response studies showed that 10(-7) to 10(-6) mol/L 9-cis RA (12 hours) resulted in peak levels of C/EBP epsilon mRNA; but even 10(-10) mol/L 9-cis RA increased levels of these transcripts.
1	Dose	Dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
9	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
17	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
20	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	12	12	NUM	CD	NumType=Card	_	_	_	_
23	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
33	epsilon	epsilon	ADP	IN	_	_	_	_	_
34	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	even	even	ADV	RB	_	_	_	_	_
38	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
40	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
43	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
46	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
47	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
51	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11415
# text = NB4 cells pulse-exposed (30 minutes) to all-trans retinoic acid (ATRA), washed, and cultured (3 days) with either dimethylsulfoxide (DMSO) or hexamethylene bisacetamide (HMBA) had a prominent increase in levels of C/EBP epsilon mRNA and an increase in granulocytic differentiation, but exposure to either DMSO or HMBA alone had no effect on base levels of C/EBP epsilon and did not induce differentiation.
1	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	pulse	pulse	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	exposed	exposed	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	30	30	NUM	CD	NumType=Card	_	_	_	_
8	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	trans	tran	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	washed	wash	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	cultured	culture	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	_
26	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	either	either	CCONJ	CC	_	_	_	_	_
30	dimethylsulfoxide	dimethylsulfoxide	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	hexamethylene	hexamethylene	NOUN	NN	Number=Sing	_	_	_	_
36	bisacetamide	bisacetamide	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	HMBA	HMBA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
43	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
49	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
50	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
51	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
57	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	but	but	CCONJ	CC	_	_	_	_	_
60	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
61	to	to	ADP	IN	_	_	_	_	_
62	either	either	CCONJ	CC	_	_	_	_	_
63	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	_
64	or	or	CCONJ	CC	_	_	_	_	_
65	HMBA	HMBA	PROPN	NNP	Number=Sing	_	_	_	_
66	alone	alone	ADV	RB	_	_	_	_	_
67	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
68	no	no	DET	DT	_	_	_	_	_
69	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
70	on	on	ADP	IN	_	_	_	_	_
71	base	base	NOUN	NN	Number=Sing	_	_	_	_
72	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
73	of	of	ADP	IN	_	_	_	_	_
74	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
76	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
77	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
78	and	and	CCONJ	CC	_	_	_	_	_
79	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
80	not	not	PART	RB	_	_	_	_	_
81	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
82	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11416
# text = Macrophage-differentiation of NB4 reduced levels of C/EBP epsilon mRNA.
1	Macrophage	Macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
6	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
12	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11417
# text = Nuclear run-off assays and half-life studies showed that accumulation of C/EBP epsilon mRNA by 9-cis RA was due to enhanced transcription.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-off	-off	ADJ	JJ	Degree=Pos	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	life	life	NOUN	NN	Number=Sing	_	_	_	_
9	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
17	epsilon	epsilon	ADP	IN	_	_	_	_	_
18	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
22	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
23	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	due	due	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11418
# text = Furthermore, this C/EBP epsilon mRNA accumulation did not require synthesis of new protein factors because 9-cis RA induced C/EBP epsilon mRNA accumulation in the absence of new protein synthesis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
10	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
13	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	because	because	SCONJ	IN	_	_	_	_	_
19	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
22	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	C/	Cith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
25	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
26	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
27	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
28	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
34	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
35	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11419
# text = ATRA also induced expression of C/EBP epsilon protein in NB4 cells, as shown by Western blotting.
1	ATRA	ATRA	ADV	RB	_	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
9	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
19	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11420
# text = In contrast to the increase of C/EBP epsilon in 9-cis RA-mediated granulocytic differentiation, the DMSO-induced differentiation of HL-60 cells down the granulocytic pathway was associated with an initial reduction of C/EBP epsilon mRNA levels.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
10	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
15	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	DMSO	Dmso	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	60	60	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	down	down	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
40	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
45	epsilon	epsilon	ADP	IN	_	_	_	_	_
46	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
47	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11421
# text = In summary, we have discovered that expression of C/EBP epsilon mRNA is markedly enhanced as the NB4 promyelocytes are induced by retinoids to differentiate towards granulocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
13	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	markedly	markedly	ADV	RB	_	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NB4	Nb4	NOUN	NN	Number=Sing	_	_	_	_
21	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
28	towards	towards	ADP	IN	_	_	_	_	_
29	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11422
# text = This induction of C/EBP epsilon mRNA expression is transcriptionally mediated and occurs in the absence of synthesis of additional protein factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	epsilon	epsilon	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11423
# text = We suspect that the C/EBP epsilon promoter/enhancer contains a retinoic acid-response element that is directly stimulated by retinoids.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suspect	suspect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	_
7	epsilon	epsilon	ADP	IN	_	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
14	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	directly	directly	ADV	RB	_	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11424
# text = Document 0030012573 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012573	0030012573	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11425
# text = Signalling via CD28 of human naive neonatal T lymphocytes.
1	Signalling	Signall	VERB	VBG	VerbForm=Ger	_	_	_	_
2	via	via	ADP	IN	_	_	_	_	_
3	CD28	Cd28	PROPN	NNP	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
7	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11426
# text = Accessory molecules play a crucial role in the development of the T cell response to antigenic challenge.
1	Accessory	Accessory	ADJ	JJ	Degree=Pos	_	_	_	_
2	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
3	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	development	development	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11427
# text = We have examined the role of CD28 in modulating the 'naive' neonatal T cell response to anti-CD2-mediated activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
12	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	'	'	PUNCT	''	_	_	_	_	_
14	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11428
# text = To compare the role of CD28, neonatal and adult T cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of anti-CD28 MoAb.
1	To	to	PART	TO	_	_	_	_	_
2	compare	compare	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
20	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
21	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
29	MoAb	MoAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11429
# text = With anti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable IL-2, whereas adult T cells proliferated vigorously, with significant IL-2 production.
1	With	with	ADP	IN	_	_	_	_	_
2	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
3	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	proliferated	proliferate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	slightly	slightly	ADV	RB	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	no	no	DET	DT	_	_	_	_	_
13	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	proliferated	proliferate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	vigorously	vigorously	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11430
# text = Costimulation with anti-CD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of adult T cells, whereas adult T cells showed only slight increases.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
4	MoAb	MoAb	PROPN	NNP	Number=Sing	_	_	_	_
5	greatly	greatly	ADV	RB	_	_	_	_	_
6	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	only	only	ADV	RB	_	_	_	_	_
30	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
31	increases	increase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11431
# text = Although IL-2 secretion was increased in the presence of anti-CD28 MoAb, neonatal T cell IL-2 production remained lower than in adults.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
13	MoAb	MoAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	_
22	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
24	than	than	ADP	IN	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11432
# text = In contrast, enhancement of IL-2 mRNA expression in neonates was similar to adult levels.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	neonates	neonate	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	adult	adult	VERB	VB	VerbForm=Inf	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11433
# text = Anti-CD28 MoAb costimulation increased NF kappa B levels in neonates, albeit to levels lower than that of adults.
1	Anti-CD28	Anti-CD28	NUM	CD	NumType=Card	_	_	_	_
2	MoAb	MoAb	PROPN	NNP	Number=Sing	_	_	_	_
3	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	neonates	neonate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	albeit	albeit	SCONJ	IN	_	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	levels	level	VERB	VB	VerbForm=Inf	_	_	_	_
15	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11434
# text = The cellular mechanism governing the diminished proliferative response of neonatal T lymphocytes to anti-CD2 may therefore be due to decreased NF kappa B induction, reduced IL-2 mRNA expression and deficient IL-2 production.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	governing	govern	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	neonatal	neonatal	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	anti-CD2	anti-cd2	NUM	CD	NumType=Card	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	therefore	therefore	ADV	RB	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	due	due	ADP	IN	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
34	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11435
# text = Although anti-CD28 MoAb costimulation enhances all of the above signals, NF kappa B and IL-2 levels remain lower than in adults, suggesting the need for further activation requirements in the neonate.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	anti-CD28	anti-CD28	PROPN	NNP	Number=Sing	_	_	_	_
3	MoAb	MoAb	PROPN	NNP	Number=Sing	_	_	_	_
4	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
5	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	above	above	ADJ	JJ	Degree=Pos	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	B	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	need	need	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	neonate	neonate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11436
# text = Document 0030012579 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012579	0030012579	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11437
# text = c-Rel and p65 subunits bind to an upstream NF-kappaB site in human granulocyte macrophage-colony stimulating factor promoter involved in phorbol ester response in 5637 cells.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	p65	p65	NUM	CD	NumType=Card	_	_	_	_
6	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
7	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
21	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
27	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	5637	5637	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11438
# text = To further clarify the complex transcriptional regulation of the human GM-CSF gene, which was extensively investigated in activated T cells, we have studied the role of an upstream NF-kappaB like site in the 5637 non-lymphoid cell line, which derives from a bladder carcinoma and constitutively produces GM-CSF.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	clarify	clarify	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	extensively	extensively	ADV	RB	_	_	_	_	_
19	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
36	like	like	ADP	IN	_	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	5637	5637	NUM	CD	NumType=Card	_	_	_	_
41	non-lymphoid	non-lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	which	which	PRON	WDT	PronType=Rel	_	_	_	_
46	derives	derive	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
47	from	from	ADP	IN	_	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	bladder	bladder	NOUN	NN	Number=Sing	_	_	_	_
50	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	constitutively	constitutively	ADV	RB	_	_	_	_	_
53	produces	produce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
54	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11439
# text = This sequence, named the A element, has an active role on GM-CSF transcription and is responsive to the tumor promoter PMA in transient transfection experiments.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	named	name	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	PMA	Pma	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
28	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
29	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11440
# text = We describe here a heterodimeric binding complex of NF-kappaB subunits (c-Rel and p65) which is identical to the one obtained using the HIV-LTR-kappaB site as recognition sequence and different from the one (c-Rel and p50) observed with nuclear extracts from Mo T-lymphoid HTLV-II infected cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	heterodimeric	heterodimeric	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	one	one	NOUN	NN	Number=Sing	_	_	_	_
26	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	LTR-kappaB	Ltr-kappab	PROPN	NNP	Number=Sing	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
35	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	one	one	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
51	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
52	from	from	ADP	IN	_	_	_	_	_
53	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	_
54	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
55	lymphoid	lymphoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
56	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	II	ii	NUM	CD	NumType=Card	_	_	_	_
59	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11441
# text = Document 0030012580 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012580	0030012580	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11442
# text = Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105.
1	Ubiquitin-	Ubiquitin-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
11	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
12	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11443
# text = Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
1	Reconstitution	Reconstitution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
7	system	system	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ubiquitin-	ubiquitin-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	carrier	carrier	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
21	ubiquitin-	ubiquitin-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	ligase	ligase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11444
# text = In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family.
1	In	in	ADP	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
15	consisting	consisting	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	p50	p50	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
34	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11445
# text = p50 is translated as a precursor of 105 kDa.
1	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	105	105	NUM	CD	NumType=Card	_	_	_	_
9	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11446
# text = The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
4	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	rapidly	rapidly	ADV	RB	_	_	_	_	_
10	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
17	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11447
# text = The mechanism of generation of p50 is not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p50	p50	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11448
# text = It has been suggested that the ubiquitin-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis, in which half of the molecule is spared, have been obscure.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ubiquitin-	ubiquitin-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
9	system	system	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
21	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
27	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	half	half	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	spared	spare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	obscure	obscure	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11449
# text = Palombella and colleagues (Palombella, V.J., Rando, O.J., Goldberg, A.L., and Maniatis, T.(1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor.
1	Palombella	Palombella	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	colleagues	colleague	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	Palombella	Palombella	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	V.J.	V.J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Rando	Rando	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	O.J.	O.J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Goldberg	Goldberg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	A.L.	A.L.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Maniatis	Maniatis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	T.	T.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	1994	1994	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	78	78	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	773-785	773-785	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	ubiquitin	ubiquitin	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
43	system	system	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	truncated	truncated	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	artificially	artificially	ADV	RB	_	_	_	_	_
49	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
54	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11450
# text = They have also shown that proteasome inhibitors block the processing both in vitro and in vivo.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	proteasome	proteasome	DET	DT	_	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	block	block	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11451
# text = In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin-carrier protein, E2-F1, that is involved in the conjugation and degradation of p53, is also required for the limited processing of the p105 precursor, and (d) a novel, approximately 320-kDa species of ubiquitin-protein ligase, is involved in the process.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
13	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
14	system	system	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	directly	directly	ADV	RB	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	a	a	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	ubiquitin-	ubiquitin-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
26	system	system	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
34	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
35	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	b	b	X	LS	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	ubiquitin	ubiquitin	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
46	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
47	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
49	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
50	step	step	NOUN	NN	Number=Sing	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	processing	processing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	c	c	X	LS	_	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	recently	recently	ADV	RB	_	_	_	_	_
60	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
61	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
62	species	species	NOUN	NNS	Number=Plur	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	ubiquitin-	ubiquitin-	SYM	NFP	_	_	_	_	SpaceAfter=No
66	carrier	carrier	NOUN	NN	Number=Sing	_	_	_	_
67	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	E2-	e2-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	F1	F1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	,	,	PUNCT	,	_	_	_	_	_
72	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
73	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
74	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
75	in	in	ADP	IN	_	_	_	_	_
76	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
77	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	_
78	and	and	CCONJ	CC	_	_	_	_	_
79	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
80	of	of	ADP	IN	_	_	_	_	_
81	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
84	also	also	ADV	RB	_	_	_	_	_
85	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
86	for	for	ADP	IN	_	_	_	_	_
87	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
88	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
89	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
90	of	of	ADP	IN	_	_	_	_	_
91	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
92	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
93	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
94	,	,	PUNCT	,	_	_	_	_	_
95	and	and	CCONJ	CC	_	_	_	_	_
96	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
97	d	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
98	)	)	PUNCT	-RRB-	_	_	_	_	_
99	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
100	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
101	,	,	PUNCT	,	_	_	_	_	_
102	approximately	approximately	ADV	RB	_	_	_	_	_
103	320	320	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
104	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
105	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
106	species	species	NOUN	NNS	Number=Plur	_	_	_	_
107	of	of	ADP	IN	_	_	_	_	_
108	ubiquitin-protein	ubiquitin-protein	ADJ	JJ	Degree=Pos	_	_	_	_
109	ligase	ligase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
110	,	,	PUNCT	,	_	_	_	_	_
111	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
112	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
113	in	in	ADP	IN	_	_	_	_	_
114	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
115	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
116	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11452
# text = This novel enzyme is distinct from E6-AP, the p53-conjugating ligase, and from E3 alpha, the "N-end rule" ligase.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	E6	e6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-conjugating	-conjugat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	ligase	ligase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
23	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	end	end	NOUN	NN	Number=Sing	_	_	_	_
26	rule	rule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	"	"	PUNCT	''	_	_	_	_	_
28	ligase	ligase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11453
# text = Document 0030012586 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012586	0030012586	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11454
# text = The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
6	directs	direct	NOUN	NNS	Number=Plur	_	_	_	_
7	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-stimulating	-stimulat	VERB	VBG	VerbForm=Ger	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11455
# text = The macrophage colony-stimulating factor (M-CSF) receptor is expressed in a tissue-specific fashion from two distinct promoters in monocytes/macrophages and the placenta.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
3	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	placenta	placenta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11456
# text = In order to further understand the transcription factors which play a role in the commitment of multipotential progenitors to the monocyte/macrophage lineage, we have initiated an investigation of the factors which activate the M-CSF receptor very early during the monocyte differentiation process.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	multipotential	multipotential	ADJ	JJ	Degree=Pos	_	_	_	_
18	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
27	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
40	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
41	very	very	ADV	RB	_	_	_	_	_
42	early	early	ADV	RB	Degree=Pos	_	_	_	_
43	during	during	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
46	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
47	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11457
# text = Here we demonstrate that the human monocytic M-CSF receptor promoter directs reporter gene activity in a tissue-specific fashion.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	ADV	RB	_	_	_	_	_
13	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11458
# text = Since one of the few transcription factors which have been implicated in the regulation of monocyte genes is the macrophage- and B-cell-specific PU.1 transcription factor, we investigated whether PU.1 binds and activates the M-CSF receptor promoter.
1	Since	since	ADP	IN	_	_	_	_	_
2	one	one	NUM	CD	NumType=Card	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	whether	whether	SCONJ	IN	_	_	_	_	_
34	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
35	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11459
# text = Here we demonstrate that both in vitro-translated PU.1 and PU.1 from nuclear extracts bind to a specific site in the M-CSF receptor promoter just upstream from the major transcription initiation site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	translated	translated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
16	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	just	just	ADV	RB	_	_	_	_	_
29	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11460
# text = Mutations in this site which eliminate PU.1 binding decrease M-CSF receptor promoter activity significantly in macrophage cell lines only.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	eliminate	eliminate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
10	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	only	only	ADV	RB	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11461
# text = Furthermore, PU.1 transactivates the M-CSF receptor promoter in nonmacrophage cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
4	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	nonmacrophage	nonmacrophage	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11462
# text = These results suggest that PU.1 plays a major role in macrophage gene regulation and development by directing the expression of a receptor for a key macrophage growth factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
6	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
26	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
27	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11463
# text = Document 0030012588 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012588	0030012588	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11464
# text = The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
3	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	females	female	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	tiny	tiny	ADJ	JJ	Degree=Pos	_	_	_	_
8	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
9	X	x	SYM	SYM	_	_	_	_	_
10	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	undergo	undergo	VERB	VB	VerbForm=Inf	_	_	_	_
20	X	x	ADP	IN	_	_	_	_	_
21	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11465
# text = Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype.
1	Mental	mental	ADJ	JJ	Degree=Pos	_	_	_	_
2	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	constellation	constellation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	congenital	congenital	ADJ	JJ	Degree=Pos	_	_	_	_
8	malformations	malformation	NOUN	NNS	Number=Plur	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	usually	usually	ADV	RB	_	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	Turner	Turner	NOUN	NN	Number=Sing	_	_	_	_
14	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	some	some	DET	DT	_	_	_	_	_
19	females	female	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	mosaic	mosaic	NOUN	NN	Number=Sing	_	_	_	_
23	45,X	45,X	ADP	IN	_	_	_	_	SpaceAfter=No
24	/46,X	/46,X	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,r	,r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	X	x	SYM	SYM	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	karyotype	karyotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11466
# text = Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	females	female	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	XIST	Xist	NOUN	NN	Number=Sing	_	_	_	_
9	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	tiny	tiny	ADJ	JJ	Degree=Pos	_	_	_	_
13	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
14	X	x	SYM	SYM	_	_	_	_	_
15	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	either	either	ADV	RB	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11467
# text = As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia, nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active.
1	As	as	ADP	IN	_	_	_	_	_
2	XIST	Xist	ADJ	JJS	Degree=Sup	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	X	x	PROPN	NNP	Number=Sing	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
15	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	spermatogonia	spermatogonia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	nonexpression	nonexpression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
24	even	even	ADV	RB	_	_	_	_	_
25	when	when	ADV	WRB	PronType=Int	_	_	_	_
26	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
27	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
29	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
35	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11468
# text = We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	ring	re	NOUN	NN	Number=Sing	_	_	_	_
8	X	X	SYM	SYM	_	_	_	_	_
9	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
10	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
11	XIST	Xist	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	XISTE	Xiste	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	three	three	NUM	CD	NumType=Card	_	_	_	_
20	females	female	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
23	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11469
# text = The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	tiny	tiny	ADJ	JJ	Degree=Pos	_	_	_	_
4	ring	re	NOUN	NN	Number=Sing	_	_	_	_
5	X	x	SYM	SYM	_	_	_	_	_
6	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
7	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	acetylated	acetylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
18	H4	H4	NOUN	NN	Number=Sing	_	_	_	_
19	marking	marking	NOUN	NN	Number=Sing	_	_	_	_
20	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	level	level	NOUN	NN	Number=Sing	_	_	_	_
28	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
32	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11470
# text = We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	tow	tow	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	XISTE	XISTE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	_
9	ring	re	NOUN	NN	Number=Sing	_	_	_	_
10	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
13	whether	whether	SCONJ	IN	_	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	normally	normally	ADV	RB	_	_	_	_	_
18	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	X	x	NOUN	NN	Number=Sing	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11471
# text = Analyses of hybrid cells show that TIMP, ZXDA, and ZXDB loci on the proximal short arm, and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	hybrid	hybrid	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	TIMP	TIMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	ZXDA	ZXDA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	ZXDB	ZXDB	PROPN	NNP	Number=Sing	_	_	_	_
13	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
18	arm	arm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	AR	be	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	PHKA1	PHKA1	NUM	CD	NumType=Card	_	_	_	_
24	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	arm	arm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	tiny	tiny	ADJ	JJ	Degree=Pos	_	_	_	_
36	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
37	X	x	SYM	SYM	_	_	_	_	_
38	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
39	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
40	XIST	Xist	ADJ	JJ	Degree=Pos	_	_	_	_
41	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11472
# text = Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
5	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	XIST	Xist	NOUN	NN	Number=Sing	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	transcribe	transcribe	VERB	VB	VerbForm=Inf	_	_	_	_
14	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	AR	ar	NOUN	NN	Number=Sing	_	_	_	_
19	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	along	along	ADP	IN	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	one	one	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	X	x	NOUN	NN	Number=Sing	_	_	_	_
30	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11473
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11474
# text = Document 0030012605 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012605	0030012605	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11475
# text = Various modes of basic helix-loop-helix protein-mediated regulation of murine leukemia virus transcription in lymphoid cell lines.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	modes	mode	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
5	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
8	protein-	protein-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11476
# text = The transcriptionally regulatory regions of the lymphomagenic Akv and SL3-3 murine leukemia retroviruses (MLVs) contain two types of E-box consensus motifs, CAGATG.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	lymphomagenic	lymphomagenic	ADJ	JJ	Degree=Pos	_	_	_	_
8	Akv	Akv	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	MLVs	MLVs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	types	type	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	box	box	NOUN	NN	Number=Sing	_	_	_	_
25	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
26	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	CAGATG	CAGATG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11477
# text = One type, EA/S, is located in the upstream promoter region, and the other, E(gre), is located in a tandem repeat with enhancer properties.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	EA/S	EA/S	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	E(	E(	X	GW	_	_	_	_	SpaceAfter=No
19	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
27	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11478
# text = We have examined the requirements of the individual E-boxes in MLV transcriptional regulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
9	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	boxes	box	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	MLV	MLV	PROPN	NNP	Number=Sing	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11479
# text = In lymphoid cell lines only, the E(gre)-binding protein complexes included ALF1 or HEB and E2A basic helix-loop-helix proteins.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	E	e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
16	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	ALF1	ALF1	PROPN	NNP	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	HEB	HEB	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	E2A	E2A	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
23	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11480
# text = Ectopic ALF1 and E2A proteins required intact E(gre) motifs for mediating transcriptional activation.
1	Ectopic	Ectopic	PROPN	NNP	Number=Sing	_	_	_	_
2	ALF1	ALF1	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	intact	intact	X	GW	_	_	_	_	_
8	E(	E(	X	GW	_	_	_	_	SpaceAfter=No
9	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11481
# text = ALF1 transactivated transcription of Akv MLV through the two E(gre) motifs equally, whereas E2A protein required the promoter-proximal E(gre) motif.
1	ALF1	ALF1	X	LS	_	_	_	_	_
2	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Akv	Akv	PROPN	NNP	Number=Sing	_	_	_	_
6	MLV	MLV	PROPN	NNP	Number=Sing	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	E(	E(	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
14	equally	equally	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
24	E	e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11482
# text = In T- and B-cell lines, the E(gre) motifs were of major importance for Akv MLV transcriptional activity, while the EA/S motif had some effect.
1	In	in	ADP	IN	_	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	E(	E(	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
18	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	Akv	Akv	PROPN	NNP	Number=Sing	_	_	_	_
21	MLV	MLV	PROPN	NNP	Number=Sing	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	while	while	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	EA/S	EA/S	PROPN	NNP	Number=Sing	_	_	_	_
28	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
29	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	some	some	DET	DT	_	_	_	_	_
31	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11483
# text = In contrast, neither E(gre) nor EA/S motifs contributed pronouncedly to Akv MLV transcription in NIH 3T3 cells lacking DNA-binding ALF1 or HEB and E2A proteins.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	neither	neither	DET	DT	_	_	_	_	_
5	E(	E(	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	nor	nor	CCONJ	CC	_	_	_	_	_
9	EA/S	EA/S	ADJ	JJ	Degree=Pos	_	_	_	_
10	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
11	contributed	contribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	pronouncedly	pronouncedly	ADV	RB	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	Akv	Akv	PROPN	NNP	Number=Sing	_	_	_	_
15	MLV	MLV	PROPN	NNP	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	NIH	Nih	PROPN	NNP	Number=Sing	_	_	_	_
19	3T3	3T3	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	ALF1	Alf1	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	HEB	Heb	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	E2A	E2a	PROPN	NNP	Number=Sing	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11484
# text = The Id1 protein was found to repress ALF1 activity in vitro and in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Id1	id1	NUM	CD	NumType=Card	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
8	ALF1	ALF1	NUM	CD	NumType=Card	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 11485
# text = Moreover, ectopic Id1 repressed E(gre)-directed but not EA/S-directed MLV transcription in lymphoid cell lines.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ectopic	ectopic	X	GW	_	_	_	_	_
4	Id1	id1	X	GW	_	_	_	_	_
5	repressed	repress	X	GW	_	_	_	_	_
6	E	e	X	GW	_	_	_	_	SpaceAfter=No
7	(	(	X	GW	_	_	_	_	SpaceAfter=No
8	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-directed	-direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	EA/S-	EA/S-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	MLV	Mlv	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11486
# text = In conclusion, E(gre) motifs and interacting basic helix-loop-helix proteins are important determinants for MLV transcriptional activity in lymphocytic cell lines.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	E(	E(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	gre	gre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
10	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
11	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	MLV	MLV	PROPN	NNP	Number=Sing	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11487
# text = Document 0030012607 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012607	0030012607	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11488
# text = Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11489
# text = The Th2-type cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), induce expression of a distinct subset of genes in human monocytes, including FcepsilonRIIb (CD23), 15-lipoxygenase, IL-1 receptor antagonist (IL-1ra), and type I and type II IL-1 receptors (IL-1R).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Th2	Th2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-type	-type	NOUN	NN	Number=Sing	_	_	_	_
4	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-13	-13	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	induce	induce	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
28	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
36	FcepsilonRIIb	FcepsilonRIIb	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CD23	CD23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
49	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-1ra	-1ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	and	and	CCONJ	CC	_	_	_	_	_
56	type	type	NOUN	NN	Number=Sing	_	_	_	_
57	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
60	II	ii	NUM	CD	NumType=Card	_	_	_	_
61	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
63	1	1	NUM	CD	NumType=Card	_	_	_	_
64	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	1R	1r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11490
# text = Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma) inhibit induction of these genes by IL-4 and IL-13.
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	type	type	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11491
# text = However, the mechanism by which IFNs mediate this inhibition has not been defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	IFNs	IFNs	PROPN	NNPS	Number=Plur	_	_	_	_
8	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11492
# text = In this overview, we discuss the role of the transcription factor, STAT6 (signal transducer and activator of transcription-6) in mediating IL-4- and IL-13-induced gene expression in monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	overview	overview	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	in	in	SCONJ	IN	_	_	_	_	_
26	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11493
# text = We also discuss our recent findings that type I and type II IFNs suppress IL-4/IL-13-inducible gene expression by inhibiting tyrosine phosphorylation and nuclear translocation of STAT6.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
6	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	IFNs	IFN	PROPN	NNP	Number=Sing	_	_	_	_
14	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
15	IL-4/IL-13	IL-4/IL-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11494
# text = The ability of type I and type II IFNs to inhibit IL-4/IL-13-induced STAT6 activity is dose- and time-dependent, and is not unique to monocytes because IFNs induce the same effects in fibroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	IFNs	IFN	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
12	IL-4/IL-13	IL-4/IL-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	because	because	SCONJ	IN	_	_	_	_	_
31	IFNs	IFN	PROPN	NNPS	Number=Plur	_	_	_	_
32	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
35	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11495
# text = Inhibition of STAT6 activity is not evident unless cells are preincubated with IFN for at least 1 h before IL-4 stimulation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
8	unless	unless	SCONJ	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	at	at	ADV	RB	_	_	_	_	_
16	least	least	ADV	RBS	Degree=Sup	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	h	h	NOUN	NN	Number=Sing	_	_	_	_
19	before	before	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11496
# text = Furthermore, inhibition can be blocked by actinomycin D, indicating a requirement for de novo transcription.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	actinomycin	actinomycin	ADP	IN	_	_	_	_	_
9	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	de	de	PROPN	NNP	Number=Sing	_	_	_	_
16	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11497
# text = We propose a model in which stimulation of monocytes by IFN activates de novo synthesis of an inhibitory factor, possibly one or more members of the SOCS/ SSI/CIS gene family, capable of suppressing activation of STAT6 by IL-4 and IL-13.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
12	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
13	de	de	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	novo	novo	ADJ	JJ	Degree=Pos	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	possibly	possibly	ADV	RB	_	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
25	members	member	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	SOCS	SOCS	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	_
30	SSI	SSI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	CIS	CIS	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
34	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
37	of	of	SCONJ	IN	_	_	_	_	_
38	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	4	4	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11498
# text = Because STAT6 activation plays an essential role in IL-4/IL-13-induced gene expression, the ability of IFN-beta and IFN-gamma to inhibit STAT6 activity provides an explanation for how IFNs can suppress IL-4/IL-13-inducible gene expression.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	IL-4/IL-13	IL-4/IL-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
26	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
31	for	for	SCONJ	IN	_	_	_	_	_
32	how	how	ADV	WRB	PronType=Int	_	_	_	_
33	IFNs	IFN	NOUN	NNS	Number=Plur	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
36	IL-4/IL-13	IL-4/IL-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11499
# text = Document 0030012611 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012611	0030012611	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11500
# text = Positive and negative regulation of IL-2 gene expression: role of multiple regulatory sites.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11501
# text = Interleukin 2 (IL-2) is an important lymphokine required in the process of T cell activation, proliferation, clonal expansion and differentiation.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	process	process	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
24	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11502
# text = The IL-2 gene displays both T cell specific and inducible expression: it is only expressed in CD4+ T cells after antigenic or mitogenic stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	only	only	ADV	RB	_	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	T	t	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11503
# text = Several cis-acting regulatory sites are required for induction of the IL-2 gene after stimulation.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11504
# text = In this study, we have analysed the function of these cis-acting regulatory sites in the context of the native IL-2 enhancer and promoter sequence.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	context	context	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11505
# text = The results of this study suggest that the NFAT (-276 to -261), the distal octamer (-256 to -248) and the proximal octamer (-75 to -66) sites not only act as enhancers of IL-2 gene transcription in the presence of cellular stimulation, but also have a silencing effect on IL-2 gene expression in resting cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
10	(-276	(-276	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	261	261	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
18	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	256	256	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	248	248	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
29	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
30	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
31	75	75	NUM	CD	NumType=Card	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	66	66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	not	not	ADV	RB	_	_	_	_	_
38	only	only	ADV	RB	_	_	_	_	_
39	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	as	as	SCONJ	IN	_	_	_	_	_
41	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
53	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	but	but	CCONJ	CC	_	_	_	_	_
56	also	also	ADV	RB	_	_	_	_	_
57	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
58	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	silencing	silence	NOUN	NN	Number=Sing	_	_	_	_
60	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
61	on	on	ADP	IN	_	_	_	_	_
62	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	2	2	NUM	CD	NumType=Card	_	_	_	_
65	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
66	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
67	in	in	ADP	IN	_	_	_	_	_
68	resting	rest	ADJ	JJ	Degree=Pos	_	_	_	_
69	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11506
# text = Two other sites display disparate effects on IL-2 gene expression in different T leukemia cell lines: the distal purine box (-291 to -277) and the proximal purine box sites (-145 to -128).
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	disparate	disparate	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
22	purine	purine	NOUN	NN	Number=Sing	_	_	_	_
23	box	box	NOUN	NN	Number=Sing	_	_	_	_
24	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
25	291	291	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	277	277	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
33	purine	purine	NOUN	NN	Number=Sing	_	_	_	_
34	box	box	NOUN	NN	Number=Sing	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	145	145	NUM	CD	NumType=Card	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	128	128	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11507
# text = Finally, the AP-1 (-186 to -176) and the kappa B sites (-206 to -195) respond to different cellular activation in EL4 cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	-186	-186	NUM	CD	NumType=Card	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	176	176	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
19	206	206	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	195	195	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	respond	respond	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	EL4	EL4	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11508
# text = The AP-1 site mediated the response to PMA stimulation while the kappa B site responded to IL-1 stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
12	while	while	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11509
# text = These data suggest that the regulation of IL-2 gene expression is a complex process and multiple cis-acting regulatory sites interact to exert different effects in T cells representative of alternative stages of differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
16	process	process	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
22	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	representative	representative	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
35	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11510
# text = Document 0030012613 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012613	0030012613	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11511
# text = Nuclear transcription factors that bind to elements of the IL-2 promoter.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11512
# text = Induction requirements in primary human T cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11513
# text = Prior studies have identified several elements that contribute to the activity of the IL-2 promoter in the stimulated T cell line, Jurkat.
1	Prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11514
# text = The sites and their corresponding nuclear binding factors include: NF-kappa B, AP-1, AP-3, OCT-1, and NF-AT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	corresponding	correspond	NOUN	NN	Number=Sing	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	OCT	Oct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11515
# text = The latter "nuclear factor for activated T cells" likely contributes to the tissue specificity of IL-2 gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
3	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	"	"	PUNCT	``	_	_	_	_	_
11	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
12	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
16	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11516
# text = Using electrophoretic mobility shift assays, we have studied these transcription factors in primary T cells from human blood to verify their presence in a physiologic setting and to identify the signals that stimulate factor activity.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	verify	verify	VERB	VB	VerbForm=Inf	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
27	setting	set	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11517
# text = All factors are induced in the nuclei of T cells upon activation with mitogens but not with exogenous IL-2 growth factor.
1	All	all	DET	DT	_	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11518
# text = However, the signaling requirements and sensitivity to protein synthesis inhibitors differ considerably.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
5	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
10	synthesis	synthesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
12	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	considerably	considerably	ADV	RB	_	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11519
# text = Only the activities for NF-AT and AP-1 sites require two signals for optimal induction, i.e., PMA plus either lectin or antibody to the CD3 or CD28 surface molecules.
1	Only	only	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
23	plus	plus	CCONJ	CC	_	_	_	_	_
24	either	either	CCONJ	CC	_	_	_	_	_
25	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
33	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
34	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11520
# text = Other factors are induced by lectin, antibody, and/or PMA alone.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	antibody	antibody	PRON	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	or	or	CCONJ	CC	_	_	_	_	_
13	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
14	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11521
# text = After appropriate stimulation, both NF-AT and AP-1 are peculiarly sensitive to the protein synthesis inhibitor anisomycin.
1	After	after	ADP	IN	_	_	_	_	_
2	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	both	both	CCONJ	CC	_	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	peculiarly	peculiarly	ADV	RB	_	_	_	_	_
15	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
21	anisomycin	anisomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11522
# text = Our data correlate the activity of NF-AT and AP-1 in gel shift assays with the two signals requirements for IL-2 gene expression.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	correlate	correlate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
22	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11523
# text = Document 0030012617 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012617	0030012617	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11524
# text = Cytokine-modulating activity of tepoxalin, a new potential antirheumatic.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
10	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
11	antirheumatic	antirheumatic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11525
# text = Tepoxalin is a new dual cyclooxygenase/5-lipoxygenase anti-inflammatory compound currently under clinical investigation.
1	Tepoxalin	Tepoxalin	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
6	cyclooxygenase	cyclooxygenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-lipoxygenase	-lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
10	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
12	currently	currently	ADV	RB	_	_	_	_	_
13	under	under	ADP	IN	_	_	_	_	_
14	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
15	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11526
# text = It has been shown to possess anti-inflammatory activity in a variety of animal models and more recently to inhibit IL-2 induced signal transduction.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	possess	possess	VERB	VB	VerbForm=Inf	_	_	_	_
7	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
14	models	model	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	more	more	ADV	RBR	_	_	_	_	_
17	recently	recently	ADV	RB	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
25	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11527
# text = The current study was conducted to evaluate the cytokine modulating activity of tepoxalin and the role of iron in these effects.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	iron	iron	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11528
# text = In human peripheral blood mononuclear cells (PBMC) stimulated with OKT3/PMA, tepoxalin inhibited lymphocyte proliferation with an IC50 of 6 microM.
1	In	in	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	tepoxalin	tepoxalin	ADP	IN	_	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	IC50	IC50	PROPN	NNP	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	6	6	NUM	CD	NumType=Card	_	_	_	_
25	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11529
# text = Additionally, it inhibited the production of LTB4 (IC50 = 0.5 microM) and the cytokines IL-2, IL-6 and TNF alpha (IC50 = 10-12 microM).
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IC50	IC50	NUM	CD	NumType=Card	_	_	_	_
11	=	=	SYM	SYM	_	_	_	_	_
12	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
13	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytokines	cytokine	PROPN	NNPS	Number=Plur	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	IC50	IC50	NUM	CD	NumType=Card	_	_	_	_
30	=	=	SYM	SYM	_	_	_	_	_
31	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-12	-12	NUM	CD	NumType=Card	_	_	_	_
33	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11530
# text = Cytotoxicity was not demonstrated at these concentrations.
1	Cytotoxicity	Cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11531
# text = Add-back experiments with either cytokines (IL-2 or IL-6), LTB4 or conditioned media failed to restore the proliferative response in the presence of tepoxalin.
1	Add	add	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	back	back	ADP	RP	_	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	either	either	DET	DT	_	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	LTB4	LTB4	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	media	media	NOUN	NN	Number=Sing	_	_	_	_
22	failed	fail	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11532
# text = However, the concurrent addition of iron (in the form of ferrous or ferric chloride and other iron salts) reversed the inhibition of proliferation caused by tepoxalin.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	concurrent	concurrent	ADJ	JJ	Degree=Pos	_	_	_	_
5	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	iron	iron	ADJ	JJ	Degree=Pos	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	form	form	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	ferrous	ferrous	ADJ	JJ	Degree=Pos	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	ferric	ferric	ADJ	JJ	Degree=Pos	_	_	_	_
16	chloride	chloride	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	iron	iron	ADJ	JJ	Degree=Pos	_	_	_	_
20	salts	salt	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	reversed	reverse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
27	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11533
# text = Tepoxalin also inhibits the activation of NF kappa B, a transcription factor which acts on several cytokine genes.
1	Tepoxalin	Tepoxalin	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11534
# text = Tepoxalin's effect on NF kappa B is also reversed by the addition of iron salts.
1	Tepoxalin	Tepoxalin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	's	's	PART	POS	_	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	B	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	iron	iron	ADJ	JJ	Degree=Pos	_	_	_	_
16	salts	salt	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11535
# text = These data suggest that the action of tepoxalin to inhibit proliferation in PBMC may be at least in part due to its ability to reduce the amount of available iron resulting in decreased activation of NF kappa B and subsequent inhibition of cytokine production.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	action	action	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	at	at	ADV	RB	_	_	_	_	_
17	least	least	ADV	RBS	Degree=Sup	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	part	part	NOUN	NN	Number=Sing	_	_	_	_
20	due	due	ADP	IN	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	reduce	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
30	iron	iron	NOUN	NN	Number=Sing	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B	B	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
41	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
44	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11536
# text = Document 0030012618 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012618	0030012618	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11537
# text = Role of the X2 box in activated transcription from the DRA promoter in B cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
5	box	box	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11538
# text = We investigated the function of the evolutionary conserved X2 box in the promoter of the HLA-DRA gene from the human major histocompatibility complex (MHC) in resting and activated B cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	evolutionary	evolutionary	NOUN	NN	Number=Sing	_	_	_	_
8	conserved	conserve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	X2	X2	NUM	CD	NumType=Card	_	_	_	_
10	box	box	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
24	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	resting	resting	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11539
# text = NF-X2, which contains members of the AP-1/ATF/CREB families of transcription factors, interacts with the X2 box (5'-TGCGTCA-3') from positions -97 to -91 in the DRA promoter.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	members	member	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1/ATF	1/atf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
15	families	familie	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	interacts	interacts	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
24	box	box	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	5'-TGCGTCA	5'-TGCGTCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	97	97	NUM	CD	NumType=Card	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	91	91	NUM	CD	NumType=Card	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
41	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11540
# text = In resting Raji cells, little to no binding to the X2 box was observed.
1	In	in	ADP	IN	_	_	_	_	_
2	resting	rest	ADJ	JJ	Degree=Pos	_	_	_	_
3	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
13	box	box	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11541
# text = In sharp contrast, in B cells treated with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), strong interactions between the X2 box and NF-X2 containing c-Fos were observed.
1	In	in	ADP	IN	_	_	_	_	_
2	sharp	sharp	ADJ	JJ	Degree=Pos	_	_	_	_
3	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
12	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
13	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
21	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
25	box	box	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
30	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
31	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11542
# text = As determined by transient expression and RNA analyses, the activation of protein kinase C (PKC) also increased rates of transcription from the wild-type DRA promoter but not from a DRA promoter bearing clustered point mutations in the X2 box.
1	As	as	SCONJ	IN	_	_	_	_	_
2	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
8	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	C	C	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	rates	rate	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	not	not	ADV	RB	_	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
38	clustered	clustered	ADJ	JJ	Degree=Pos	_	_	_	_
39	point	point	NOUN	NN	Number=Sing	_	_	_	_
40	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
44	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11543
# text = Since the co-expression with a dominant negative c-Fos abolished the responsiveness to TPA, we conclude that activated transcription of the DRA gene depends on interactions between the X2 box and NF-X2, which contains c-Fos.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	co-expression	co-expression	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
7	negative	negative	NOUN	NN	Number=Sing	_	_	_	_
8	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
10	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
28	between	between	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
31	box	box	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	which	which	PRON	WDT	PronType=Rel	_	_	_	_
38	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
40	Fos.	Fos.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11544
# text = Document 0030012624 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012624	0030012624	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11545
# text = Expression of transcription factor genes after influenza A virus infection.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	after	after	ADP	IN	_	_	_	_	_
7	influenza	influenza	NOUN	NN	Number=Sing	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11546
# text = Infection of human monocytes with influenza
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	influenza	influenza	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 11547
# text = A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	broad	broad	ADJ	JJ	Degree=Pos	_	_	_	_
6	range	range	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	attracting	attract	VERB	VBG	VerbForm=Ger	_	_	_	_
14	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
15	before	before	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	undergo	undergo	ADJ	JJ	Degree=Pos	_	_	_	_
20	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11548
# text = The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorly understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
11	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	still	still	ADV	RB	_	_	_	_	_
17	poorly	poorly	ADJ	JJ	Degree=Pos	_	_	_	_
18	understood	understand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11549
# text = Activation of NF-kappa B seems to play an important role in the regulation of many proinflammatory cytokine genes, but cannot be the only mechanism, since several cytokine genes lack respective binding sites in their promoter regions.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
18	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
24	not	not	PART	RB	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
28	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	since	since	SCONJ	IN	_	_	_	_	_
31	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
34	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
35	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
36	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
37	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
41	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11550
# text = Therefore, we additionally investigated other transcription factors of possible importance such as CREB, CTF, OTF-1, and OTF-2.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	additionally	additionally	ADV	RB	_	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
11	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	CTF	CTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11551
# text = To explore long-term regulatory mechanisms, we investigated the induction of transcription factors on the gene expression level which may be important to substitute for metabolized transcription factor proteins after their activation.
1	To	to	PART	TO	_	_	_	_	_
2	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
3	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	term	term	NOUN	NN	Number=Sing	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	substitute	substitute	VERB	VB	VerbForm=Inf	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	metabolized	metabolize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	after	after	ADP	IN	_	_	_	_	_
33	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11552
# text = We identified a cell-type-specific differential response: CREB, CTF, OTF-1, OFT-2, and NF-kappa B genes were strongly induced 1 to 4 hours after influenza
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	differential	differential	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CTF	CTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	OFT	OFT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	strongly	strongly	ADV	RB	_	_	_	_	_
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	4	4	NUM	CD	NumType=Card	_	_	_	_
36	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
37	after	after	ADP	IN	_	_	_	_	_
38	influenza	influenza	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 11553
# text = A virus infection in the monocytic cell line Mono Mac 6, while in freshly prepared human monocytes no significant changes were detected.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
3	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	Mono	Mono	PROPN	NNP	Number=Sing	_	_	_	_
10	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	_
11	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	while	while	SCONJ	IN	_	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	freshly	freshly	ADV	RB	_	_	_	_	_
16	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	no	no	DET	DT	_	_	_	_	_
20	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
21	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11554
# text = In infected monocytes, which die by apoptosis, the expression of CREB, CTF, and OTF-2 was rather suppressed 8 hours after infection.
1	In	in	ADP	IN	_	_	_	_	_
2	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	die	die	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	apoptosis	apoptosis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	CTF	CTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	OTF	OTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	rather	rather	ADV	RB	_	_	_	_	_
23	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	8	8	NUM	CD	NumType=Card	_	_	_	_
25	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11555
# text = In conclusion, the long-term regulation of transcription factor gene expression in non-proliferating cells seems to be of minor importance after influenza infection since in apoptosisprone cells an immediate availability of transcription factor proteins is required.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	term	term	NOUN	NN	Number=Sing	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	non-proliferating	non-proliferat	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	minor	minor	ADJ	JJ	Degree=Pos	_	_	_	_
22	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
23	after	after	ADP	IN	_	_	_	_	_
24	influenza	influenza	ADJ	JJ	Degree=Pos	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	since	since	SCONJ	IN	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	apoptosisprone	apoptosisprone	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
32	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11556
# text = Document 0030012626 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012626	0030012626	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11557
# text = Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	helix	helix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-loop	-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	E2A	E2a	PROPN	NNP	Number=Sing	_	_	_	_
16	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11558
# text = The E2A gene encodes transcription factors of the helix-loop-helix family that are implicated in cell-specific gene expression as part of dimeric complexes that interact with E box enhancer elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	_
3	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
12	family	family	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	part	part	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	dimeric	dimeric	ADJ	JJ	Degree=Pos	_	_	_	_
26	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	E	e	NOUN	NN	Number=Sing	_	_	_	_
31	box	box	NOUN	NN	Number=Sing	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11559
# text = It has previously been shown that transcripts of the E2A gene can be detected in a wide range of cell types.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	E2A	E2a	PROPN	NNP	Number=Sing	_	_	_	_
11	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
18	range	range	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11560
# text = We have now examined expression of the mouse E2A gene at the protein level using polyclonal antisera directed against distinct portions of the E2A protein to probe blots of cellular extracts.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	E2	E2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
18	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	_
19	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	against	against	ADP	IN	_	_	_	_	_
21	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	portions	portion	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	E2A	E2A	PROPN	NNP	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	probe	probe	VERB	VB	VerbForm=Inf	_	_	_	_
29	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
32	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11561
# text = A 73 kDa protein was identified by this analysis: this protein is highly enriched in cell lines of B lymphoid origin as compared to pancreatic beta-cells and fibroblast cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	73	73	NUM	CD	NumType=Card	_	_	_	_
3	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	highly	highly	ADV	RB	_	_	_	_	_
15	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	pancreatic	pancreatic	ADJ	JJ	Degree=Pos	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11562
# text = The detection of this protein selectively in extracts of lymphoid cells correlates with the presence of the E box-binding activity LEF1/BCF1 in these cells; this binding activity was previously shown to be efficiently recognized by antiserum directed against E2A gene products.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	selectively	selectively	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	E	e	NOUN	NN	Number=Sing	_	_	_	_
19	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	LEF1/BCF1	Lef1/bcf1	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	previously	previously	ADV	RB	_	_	_	_	_
33	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	efficiently	efficiently	ADV	RB	_	_	_	_	_
37	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
40	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	against	against	ADP	IN	_	_	_	_	_
42	E2A	E2a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
44	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11563
# text = Transfection of cells with full length E2A cDNA leads to appearance of protein co-migrating with the 73 kDa protein on SDS gel electrophoresis and co-migrating with LEF1/BCF1 on mobility shift analysis.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
6	length	length	NOUN	NN	Number=Sing	_	_	_	_
7	E2	E2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
10	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	co-migrating	co-migrat	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	73	73	NUM	CD	NumType=Card	_	_	_	_
19	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	SDS	SDS	NOUN	NN	Number=Sing	_	_	_	_
23	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
24	electrophoresis	electrophoresis	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	co-migrating	co-migrat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	LEF1/BCF1	LEF1/BCF1	PROPN	NNP	Number=Sing	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
31	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
32	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11564
# text = Our results are consistent with the view that the DNA-binding activity LEF1/BCF1 is a homodimer of E2A proteins; the selective appearance of this putative cell-specific transcription factor in B lymphoid cells seems to be attributable, at least in part, to the elevated E2A protein concentrations in these cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	view	view	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	LEF1/	Lef1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	BCF1	Bcf1	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	E2A	E2a	PROPN	NNP	Number=Sing	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
25	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
36	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	at	at	ADV	RB	_	_	_	_	_
44	least	least	ADV	RBS	Degree=Sup	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	E2A	E2a	NOUN	NN	Number=Sing	_	_	_	_
52	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
53	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
56	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11565
# text = Document 0030012630 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012630	0030012630	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11566
# text = Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
3	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11567
# text = Inducible nitric oxide (iNO) is produced at sites of vascular inflammation by resident and nonresident vascular wall cells, but its role in the inflammatory process is not known.
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
3	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	iNO	iNO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
13	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	resident	resident	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	nonresident	nonresident	ADJ	JJ	Degree=Pos	_	_	_	_
18	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
19	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
24	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	process	process	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11568
# text = In this study, we show that a novel function of iNO is to terminate inflammatory processes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	iNO	iNO	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	terminate	terminate	VERB	VB	VerbForm=Inf	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11569
# text = We find that iNO produced by murine macrophage-like cells, RAW264.7, can inhibit cytokine-induced endothelial cell activation in a separated and mixed endothelial-RAW264.7 coculture system.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	iNO	ino	PROPN	NNP	Number=Sing	_	_	_	_
5	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	264.7	264.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	RAW264.7	RAW264.7	NOUN	NN	Number=Sing	_	_	_	_
32	coculture	coculture	NOUN	NN	Number=Sing	_	_	_	_
33	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11570
# text = Both iNO production and endothelial VCAM-1 expression were induced simultaneously with bacterial LPS and murine-specific IFN-gamma.
1	Both	both	DET	DT	_	_	_	_	_
2	iNO	ino	ADJ	JJ	Degree=Pos	_	_	_	_
3	production	production	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
15	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	murine	murine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11571
# text = Inhibition of iNO synthase (iNOS) activity with N omega-monomethyl-L-arginine in endothelial-RAW264.7 cocultures, stimulated with murine-specific IFN-gamma and LPS, decreased iNO production by 86%, augmented VCAM-1 and iNOS expression in endothelial and RAW264.7 cells, respectively, and increased monocyte adhesion to the endothelial cell surface.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	iNO	ino	DET	DT	_	_	_	_	_
4	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	iNOS	iNOS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	N	N	PROPN	NNP	Number=Sing	_	_	_	_
11	omega	omega	X	AFX	_	_	_	_	SpaceAfter=No
12	-monomethyl	-monomethyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	L	l	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-RAW264.7	-RAW264.7	NUM	CD	NumType=Card	_	_	_	_
20	cocultures	coculture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	murine	murine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	iNO	ino	DET	DT	_	_	_	_	_
35	production	production	NOUN	NN	Number=Sing	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	86	86	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	VCAM	VCAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	iNOS	inos	ADJ	JJ	Degree=Pos	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	RAW	raw	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
59	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
60	to	to	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
63	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
64	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11572
# text = Transient transfection studies using various VCAM-1 promoter constructs demonstrated that inhibitory effects of iNO on VCAM-1 gene transcription were mediated, in part, by inhibitory effects of iNO on kappa B cis-acting elements.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
6	VCAM	VCAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
11	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
14	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	iNO	iNO	PROPN	NNP	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	VCAM	VCAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	iNO	iNO	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
40	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11573
# text = Immunofluorescence studies using an Ab to the RelA (p65) subunit of nuclear factor-kappa B revealed that iNO inhibited the activation of nuclear factor-kappa B.
1	Immunofluorescence	Immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	iNO	iNO	PROPN	NNP	Number=Sing	_	_	_	_
22	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11574
# text = These studies indicate that iNO attenuates iNOS expression in macrophages and inhibits monocyte adhesion to endothelial cells, and suggest that endogenously derived iNO may be an important autoregulatory inhibitor of vascular inflammation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	iNO	iNO	X	GW	_	_	_	_	_
6	attenuates	attenuate	X	GW	_	_	_	_	_
7	iNOS	inos	X	GW	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	endogenously	endogenously	ADV	RB	_	_	_	_	_
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	iNO	ino	PROPN	NNP	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
33	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11575
# text = Document 0030012632 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012632	0030012632	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11576
# text = Human cytomegalovirus binding to human monocytes induces immunoregulatory gene expression.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
8	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11577
# text = To continue our investigation of the cellular events that occur following human CMV (HCMV) infection, we focused on the regulation of cellular activation following viral binding to human monocytes.
1	To	to	PART	TO	_	_	_	_	_
2	continue	continue	VERB	VB	VerbForm=Inf	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	focused	focus	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11578
# text = First, we showed that viral binding induced a number of immunoregulatory genes (IL-1beta, A20, NF-kappaB-p105/p50, and IkappaBalpha) in unactivated monocytes and that neutralizing
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	number	number	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	A20	A20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-kappaB-p105/p50	-kappaB-p105/p50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 11579
# text = Abs to the major HCMV glycoproteins, gB (UL55) and gH (UL75), inhibited the induction of these genes.
1	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	HCMV	Hcmv	NOUN	NN	Number=Sing	_	_	_	_
6	glycoproteins	glycoprotein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	gB	gB	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	UL55	UL55	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	gH	gH	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	UL75	UL75	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11580
# text = Next, we demonstrated that these viral ligands directly up-regulated monocyte gene expression upon their binding to their appropriate cellular receptors.
1	Next	next	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
8	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
9	directly	directly	ADV	RB	_	_	_	_	_
10	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	upon	upon	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11581
# text = We then investigated if HCMV binding also resulted in the translation and secretion of cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	then	then	ADV	RB	PronType=Dem	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	if	if	SCONJ	IN	_	_	_	_	_
5	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11582
# text = Our results showed that HCMV binding to monocytes resulted in the production and release of IL-1beta protein.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	release	release	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11583
# text = Because these induced gene products have NF-kappaB sites in their promoter regions, we next examined whether there was an up-regulation of nuclear NF-kappaB levels.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	products	product	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	next	next	ADV	RB	_	_	_	_	_
18	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	whether	whether	SCONJ	IN	_	_	_	_	_
20	there	there	PRON	EX	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11584
# text = These experiments showed that, in fact, NF-kappaB was translocated to the nucleus following viral binding or purified viral ligand binding.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
17	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11585
# text = Changes in IkappaBalpha levels correlated with the changes in NF-kappaB translocation.
1	Changes	change	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11586
# text = Lastly, we demonstrated that p38 kinase activity played a central role in IL-1beta production and that it was rapidly up-regulated following infection.
1	Lastly	Lastly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	p38	p38	NUM	CD	NumType=Card	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	played	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	rapidly	rapidly	ADV	RB	_	_	_	_	_
24	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11587
# text = These results support our hypothesis that HCMV initiates a signal transduction pathway that leads to monocyte activation and pinpoints a potential mechanism whereby HCMV infection of monocytes can result in profound pathogenesis, especially in chronic inflammatory-type conditions.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	hypothesis	hypothesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	HCMV	HCMV	NOUN	NN	Number=Sing	_	_	_	_
8	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	pinpoints	pinpoint	NOUN	NNS	Number=Plur	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	whereby	whereby	ADP	IN	_	_	_	_	_
24	HCMV	Hcmv	PROPN	NNP	Number=Sing	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
32	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	especially	especially	ADV	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
37	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	type	type	NOUN	NN	Number=Sing	_	_	_	_
40	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11588
# text = Document 0030012642 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012642	0030012642	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11589
# text = Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.
1	Evidence	evidence	SCONJ	IN	_	_	_	_	_
2	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	limiting	limiting	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11590
# text = Cyclosporine (CsA) is both a clinical immunosuppressive drug and a probe to dissect intracellular signaling pathways.
1	Cyclosporine	Cyclosporine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	both	both	DET	PDT	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
10	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	dissect	dissect	VERB	VB	VerbForm=Inf	_	_	_	_
16	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11591
# text = In vitro, CsA inhibits lymphocyte gene activation by inhibiting the phosphatase activity of calcineurin (CN).
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
6	lymphocyte	lymphocyte	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CN	CN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11592
# text = In clinical use, CsA treatment inhibits 50-75% of CN activity in circulating leukocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	use	use	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
8	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CN	Cn	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11593
# text = We modeled this degree of CN inhibition in primary human leukocytes in vitro in order to study the effect of partial CN inhibition on the downstream signaling events that lead to gene activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	modeled	model	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	order	order	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
22	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
27	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
28	events	event	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11594
# text = In CsA-treated leukocytes stimulated by calcium ionophore, the degree of reduction in CN activity was accompanied by a similar degree of inhibition of each event tested: dephosphorylation of nuclear factor of activated T cell proteins, nuclear DNA binding, activation of a transfected reporter gene construct, IFN-gamma and IL-2 mRNA accumulation, and IFN-gamma production.
1	In	in	ADP	IN	_	_	_	_	_
2	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
9	ionophore	ionophore	ADV	RB	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	CN	CN	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
23	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	each	each	DET	DT	_	_	_	_	_
28	event	event	NOUN	NN	Number=Sing	_	_	_	_
29	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
30	:	:	PUNCT	:	_	_	_	_	_
31	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
42	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
50	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
51	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	2	2	NUM	CD	NumType=Card	_	_	_	_
60	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
61	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
67	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11595
# text = Furthermore, the degree of CN inhibition was reflected by a similar degree of reduction in lymphocyte proliferation and IFN-gamma production in the allogeneic mixed lymphocyte cultures.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	reflected	reflect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
13	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	allogeneic	allogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
27	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
29	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11596
# text = These data support the conclusion that CN activity is rate-limiting for the activation of primary human T lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	CN	Cn	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	limiting	limiting	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	NOUN	NN	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11597
# text = Thus, the reduction of CN activity observed in CsA-treated patients is accompanied by a similar degree of reduction in lymphocyte gene activation, and accounts for the immunosuppression observed.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	CN	PROPN	NNP	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
19	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	accounts	account	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
32	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11598
# text = Document 0030012646 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012646	0030012646	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11599
# text = Activation of transcription by binding of NF-E1 (YY1) to a newly identified element in the first exon of the human DR alpha gene.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	SCONJ	IN	_	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	YY1	YY1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	newly	newly	ADV	RB	_	_	_	_	_
16	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
21	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	DR	Dr	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	ADP	IN	_	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11600
# text = A previously unrecognized element, located downstream of the start site of transcription in the first exon of the DR alpha gene, has been defined that enhances promoter activity up to eightfold in a position-dependent manner.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	start	start	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
17	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	ADP	IN	_	_	_	_	_
22	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	up	up	ADV	RB	_	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	eightfold	eightfold	VERB	VB	VerbForm=Inf	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	position	position	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11601
# text = Mutations in this DNA-binding site abolished binding of a nuclear factor in human B cell nuclear extract and decreased the activity of the DR alpha promoter to a basal level.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11602
# text = Significant sequence homology of this element was found in the DNA of the DR beta, DP alpha and -beta, and DQ alpha genes, always located downstream of the transcriptional start site.
1	Significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	DP	DP	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	DQ	Dq	ADJ	JJ	Degree=Pos	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	always	always	ADV	RB	_	_	_	_	_
29	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
34	start	start	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11603
# text = The nuclear factor binds to the DR alpha and DP alpha element but not to the element in the DQ alpha gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	DP	DP	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
21	alpha	alpha	ADP	IN	_	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11604
# text = It was identified as NF-E1 (YY1).
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	YY	Yy	INTJ	UH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11605
# text = This protein, previously identified by its binding to the Ig kappa
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	previously	previously	ADV	RB	_	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
8	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 11606
# text = 3' enhancer and the Ig heavy chain mu E1 site, thus also appears to be quite important in the regulation of MHC class II gene expression.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	'	'	PUNCT	``	_	_	_	_	_
3	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
7	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	mu	mu	NOUN	NN	Number=Sing	_	_	_	_
10	E1	E1	NUM	CD	NumType=Card	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	thus	thus	ADV	RB	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	quite	quite	ADV	RB	_	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
25	class	class	NOUN	NN	Number=Sing	_	_	_	_
26	II	ii	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11607
# text = Document 0030012648 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012648	0030012648	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11608
# text = Identification of upstream regulatory elements that repress expression of adult beta-like globin genes in a primitive erythroid environment.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	repress	repress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	environment	environment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11609
# text = Our investigations have focused on localizing cis-elements responsible for the down regulation of the adult beta-like globin genes (delta and beta) in immature, or primitive erythroid tissues.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	investigations	investigation	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	on	on	SCONJ	IN	_	_	_	_	_
6	localizing	localizing	VERB	VBG	VerbForm=Ger	_	_	_	_
7	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	down	down	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
33	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
34	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11610
# text = We studied their activity after transfection into K562 cells, an erythroleukemia cell line with an embryonic-fetal phenotype.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	K562	K562	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	erythroleukemia	erythroleukemia	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
20	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11611
# text = Analyzed DNA sequences included delta and beta 5' flanking regions extending from approximately -500 to +50bp (promoter regions), truncated delta and beta 5' flanking regions extending from approximately -250 to +50 bp, and chimeric promoter constructions, which consisted of a distal delta or beta fragment fused to a proximal beta or delta sequence.
1	Analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
4	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	_
10	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
11	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
12	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	500	500	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
19	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	truncated	truncated	ADJ	JJ	Degree=Pos	_	_	_	_
27	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
30	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	'	'	PUNCT	``	_	_	_	_	_
32	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
33	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
34	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	approximately	approximately	ADV	RB	_	_	_	_	_
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	250	250	NUM	CD	NumType=Card	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	+50	+50	NUM	CD	NumType=Card	_	_	_	_
41	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
45	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
46	constructions	construction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	which	which	PRON	WDT	PronType=Rel	_	_	_	_
49	consisted	consist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
53	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
54	or	or	CCONJ	CC	_	_	_	_	_
55	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
56	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
57	fused	fuse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
58	to	to	ADP	IN	_	_	_	_	_
59	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
60	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
61	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
62	or	or	CCONJ	CC	_	_	_	_	_
63	delta	delof	NOUN	NN	Number=Sing	_	_	_	_
64	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11612
# text = In CAT reporter constructions no appreciable level of CAT activity was supported by the beta globin promoter, and only low level activity by the delta promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
3	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
4	constructions	construction	NOUN	NNS	Number=Plur	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	appreciable	appreciable	ADJ	JJ	Degree=Pos	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	supported	support	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	globin	globin	ADP	IN	_	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11613
# text = Truncation of the beta globin promoter led to a 2-3 fold increase in promoter activity.
1	Truncation	Truncation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
14	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11614
# text = In contrast, deletion of the upstream portion of the delta promoter led to a 10 fold decrease in expression.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
18	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11615
# text = Coupling of the upstream beta globin sequence from approximately -500 to -250 bp to the truncated delta promoter fragment led to complete extinction of transcription activity, consistent with a negative regulatory effect of the beta globin gene upstream element(s).
1	Coupling	Coupling	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	approximately	approximately	ADV	RB	_	_	_	_	_
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	500	500	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	250	250	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
22	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
25	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
39	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
42	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	s	s	X	AFX	_	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11616
# text = Fusion of the upstream portion of the delta promoter to the truncated beta globin promoter yielded a modest increase in promoter strength relative to the truncated beta gene promoter, indicating the presence of a positive transcriptional element(s) in the upstream delta globin regulatory region.
1	Fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
5	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	yielded	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	modest	modest	ADJ	JJ	Degree=Pos	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	strength	strength	NOUN	NN	Number=Sing	_	_	_	_
23	relative	relative	ADV	RB	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
38	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	s	s	X	AFX	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
45	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
46	globin	globin	ADP	IN	_	_	_	_	_
47	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
48	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11617
# text = Site-directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	SCONJ	IN	_	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	BP1	BP1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	BP2	BP2	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
18	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	_
32	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
33	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
36	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11618
# text = DNase I footprinting of the upstream delta-globin region revealed protected sequences corresponding to consensus binding sites for GATA-1 and BP2.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	footprinting	footprint	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
7	delta	delta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
14	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	consensus	consensus	VERB	VB	VerbForm=Inf	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	BP2	BP2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11619
# text = These results confirm that sequences in the upstream promoter region of the adult beta globin gene contribute to its factor-mediated suppression early in development and then may modulate its expression at a later stage.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	confirm	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	globin	globin	ADP	IN	_	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
24	early	early	ADV	RB	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	then	then	ADV	RB	PronType=Dem	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
36	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11620
# text = Document 0030012649 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012649	0030012649	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11621
# text = IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
9	heterodimerization	heterodimerization	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
12	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphoblasts	lymphoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11622
# text = Despite differences in T cell responses induced by interleukin (IL)-2 and IL-7, both cytokines modulate T cell functions by activation of signal transducers and activators of transcription (STAT) proteins.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
22	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	T	t	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
30	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11623
# text = We examined the contribution of the two isoforms of STAT5, STAT5A and STAT5B, to IL-2- and IL-7-induced activation of human peripheral blood T lymphoblasts.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	A	a	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	STAT5B	STAT5B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
32	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	lymphoblasts	lymphoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11624
# text = Both cytokines induced assembly of STAT5A and STAT5B containing complexes capable of binding to the interferon-gamma activation sequence (GAS), and these complexes rapidly translocated (within 1 min) into the nucleus of IL-2- or IL-7-treated cells.
1	Both	both	DET	DT	_	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	A	A	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	STAT5B	Stat5b	PROPN	NNP	Number=Sing	_	_	_	_
10	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
13	of	of	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
29	rapidly	rapidly	ADV	RB	_	_	_	_	_
30	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	within	within	ADP	IN	_	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	into	into	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11625
# text = The kinetics of this translocation were delayed in IL-7-treated as compared to IL-2-treated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	delayed	delay	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11626
# text = IL-2 and IL-7 were equivalent in their ability to induce tyrosine phosphorylation of STAT5A and STAT5B and to facilitate binding of these STATs to an immobilized GAS element.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	A	A	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	STAT5B	STAT5B	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	STATs	STAT	NOUN	NNS	Number=Plur	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	immobilized	immobilize	ADJ	JJ	Degree=Pos	_	_	_	_
32	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11627
# text = Both IL-2 and IL-7 induced substantial amounts of STAT5A/STAT5B heterodimerization.
1	Both	both	DET	DT	_	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	7	7	NUM	CD	NumType=Card	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
11	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT5A/	Stat5a/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	STAT5B	Stat5b	NOUN	NN	Number=Sing	_	_	_	_
15	heterodimerization	heterodimerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11628
# text = Moreover, we observed constitutive association of STAT3 with each STAT5 isomer.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	association	association	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	each	each	DET	DT	_	_	_	_	_
11	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
12	isomer	isomer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11629
# text = These data suggest that IL-2 and IL-7 induce assembly of STAT heterodimers in a similar manner and that subsequent cellular responses may be driven by induction of similar sets of genes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	7	7	NUM	CD	NumType=Card	_	_	_	_
12	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
13	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
20	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
24	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_
25	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
33	sets	set	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11630
# text = Document 0030012651 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012651	0030012651	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11631
# text = Characterization of the human immunodeficiency virus type 1 enhancer-binding proteins from the human T-cell line Jurkat.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11632
# text = The transcription of the human immunodeficiency virus type 1 (HIV-1) is under the control of cellular proteins that bind to the viral long terminal repeat (LTR).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	under	under	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	control	control	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11633
# text = Among the protein-binding regions of the HIV-1 LTR is the transcription-enhancer region.
1	Among	among	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11634
# text = We show that at least one inducible, C1, and one constitutive, C2, protein can bind to the HIV enhancer in Jurkat cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	at	at	ADV	RB	_	_	_	_	_
5	least	least	ADV	RBS	Degree=Sup	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	C1	C1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	constitutive	constitutive	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	C2	c2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11635
# text = The two proteins differ in their surface charge, since they are separable by anion-exchange chromatography.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
8	charge	charge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	since	since	SCONJ	IN	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	separable	separable	ADJ	JJ	Degree=Pos	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	anion	anion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
18	chromatography	chromatography	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11636
# text = Bivalent cations such as Mg2+ and Zn2+ differentially affect their binding to oligonucleotides which contain the HIV-enhancer domain.
1	Bivalent	Bivalent	ADJ	JJ	Degree=Pos	_	_	_	_
2	cations	cation	NOUN	NNS	Number=Plur	_	_	_	_
3	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	Mg2	Mg2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Zn2	Zn2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	differentially	differentially	ADV	RB	_	_	_	_	_
11	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11637
# text = Both C1 and C2 proteins also bind to a similar sequence found in the interleukin-2-receptor alpha-subunit enhancer.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	C1	c1	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	C2	C2	NUM	CD	NumType=Card	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	bind	bind	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11638
# text = The inducible C1 protein was partially purified by three chromatographic steps and characterized by u.v. cross-linking as a 47 kDa protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
3	C1	C1	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	partially	partially	ADV	RB	_	_	_	_	_
7	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	chromatographic	chromatographic	ADJ	JJ	Degree=Pos	_	_	_	_
11	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	u.v.	u.v.	NOUN	NN	Number=Sing	_	_	_	_
16	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	47	47	NUM	CD	NumType=Card	_	_	_	_
21	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11639
# text = Document 0030012652 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012652	0030012652	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11640
# text = Cyclosporin A-resistant transactivation of the IL-2 promoter requires activity of okadaic acid-sensitive serine/threonine phosphatases.
1	Cyclosporin	Cyclosporin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
5	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
22	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11641
# text = Expression of the IL-2 gene requires activation of T cells through stimulation of the TCR and costimulation through accessory receptors.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11642
# text = We have found recently that okadaic acid-sensitive Ser/Thr phosphatases are involved in a cyclosporin A-insensitive pathway that selectively transmits costimulatory signals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	recently	recently	ADV	RB	_	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
10	Ser/	ser/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Thr	Thr	NOUN	NN	Number=Sing	_	_	_	_
12	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
18	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	selectively	selectively	ADV	RB	_	_	_	_	_
24	transmits	transmit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11643
# text = In this study, we analyzed whether activities of these phosphatases are necessary for the expression of the IL-2 gene.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11644
# text = In both activated peripheral blood T lymphocytes and activated tumorigenic T cell lines, IL-2 gene expression was blocked at the transcriptional level by okadaic acid.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	tumorigenic	tumorigenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	level	level	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
28	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11645
# text = The transcription factors active at the IL-2 promoter were differentially influenced: upon down-modulation of okadaic acid-sensitive phosphatases, transactivation by octamer, NF-kappa B, and NF of activated T cells proteins was abrogated, while transactivation by AP-1 proteins was even enhanced.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	differentially	differentially	ADV	RB	_	_	_	_	_
13	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	upon	upon	ADP	IN	_	_	_	_	_
16	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
24	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	NF	NF	ADP	IN	_	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	T	t	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	while	while	SCONJ	IN	_	_	_	_	_
46	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
50	1	1	NUM	CD	NumType=Card	_	_	_	_
51	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
52	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
53	even	even	ADV	RB	_	_	_	_	_
54	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11646
# text = Document 0030012653 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012653	0030012653	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11647
# text = TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia.
1	TCL1	TCL1	NUM	CD	NumType=Card	_	_	_	_
2	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	preleukemic	preleukemic	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	case	case	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ataxia	ataxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	telangiectasia	telangiectasia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11648
# text = The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1)] and inversions [inv14(q11;q32.1)] with TCR alpha/beta loci in T-cell leukemias, such as T-prolymphocytic (T-PLL).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCL1	TCL1	NUM	CD	NumType=Card	_	_	_	_
3	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
7	14q32.1	14q32.1	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	chromosome	chromosome	ADJ	JJ	Degree=Pos	_	_	_	_
12	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
13	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	14;14	14;14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	q11;q32.1	q11;q32.1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	t(	t(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	7;14	7;14	X	LS	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	q35;q32.1	q35;q32.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	]	]	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	inversions	inversion	NOUN	NNS	Number=Plur	_	_	_	_
31	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	inv14	inv14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	q11;	q11;	PUNCT	,	_	_	_	_	SpaceAfter=No
35	q32.1	q32.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	]	]	PUNCT	-RRB-	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	_
40	alpha/	alpha/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
42	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
49	as	as	ADP	IN	_	_	_	_	_
50	T-prolymphocytic	T-prolymphocytic	PROPN	NNP	Number=Sing	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	PLL	PLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11649
# text = It is also involved in T- acute and- chronic leukemias arising in cases of ataxia-telangiectasia (AT), an immunodeficiency syndrome.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	_
8	acute	acute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	_
11	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
12	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	_
13	arising	arise	VERB	VBG	VerbForm=Ger	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	ataxia-	ataxia-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	telangiectasia	telangiectasia	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AT	and	ADV	RB	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	immunodeficiency	immunodeficiency	ADJ	JJ	Degree=Pos	_	_	_	_
25	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11650
# text = Similar chromosomal rearrangements occur also in the clonally expanded T cells in AT patients before the appearance of the overt leukemia.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
3	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
4	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	clonally	clonally	ADV	RB	_	_	_	_	_
9	expanded	expand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	before	before	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	overt	overt	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11651
# text = We have analyzed the expression of TCL1 mRNA and protein in peripheral blood lymphocytes (PBLs) from four AT cases and from healthy controls.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TCL1	TCL1	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	PBLs	PBL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	four	four	NUM	CD	NumType=Card	_	_	_	_
20	AT	at	ADP	IN	_	_	_	_	_
21	cases	casis	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
25	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11652
# text = We found that the TCL1 gene was overexpressed in the PBLs of an AT patient with a large clonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCL1	tCL1	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	PBLs	PBLs	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	AT	at	ADJ	JJ	Degree=Pos	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
19	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
20	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	population	population	NOUN	NN	Number=Sing	_	_	_	_
23	exhibiting	exhibite	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	14;14	14;14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
38	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11653
# text = Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the distal part of chromosome 14.
1	Fluorescence	Fluorescence	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
4	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TCL1	TCL1	NUM	CD	NumType=Card	_	_	_	_
8	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
9	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	lymphocyte	lymphocyte	VERB	VB	VerbForm=Inf	_	_	_	_
12	metaphases	metaphase	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	AT	At	NOUN	NN	Number=Sing	_	_	_	_
16	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
22	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
23	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	breakpoint	breakpoint	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	14;	14;	PUNCT	,	_	_	_	_	SpaceAfter=No
32	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
35	lies	lie	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	within	within	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	TCL1	tCL1	NOUN	NN	Number=Sing	_	_	_	_
39	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	inverted	invert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	duplication	duplication	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
50	part	part	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
53	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11654
# text = These data indicate that TCL1 is activated in preleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at 14q11.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TCL1	TCL1	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	preleukemic	preleukemic	ADJ	JJ	Degree=Pos	_	_	_	_
10	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	chromosome	chromosome	DET	DT	_	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
23	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	14q11	14q11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11655
# text = Deregulation of TCL1 is the first event in the initiation of malignancy in these types of leukemias and represents a potential tool for clinical evaluation.
1	Deregulation	deregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TCL1	TCL1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	event	event	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	types	type	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
22	tool	tool	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
25	evaluation	evaluation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11656
# text = Document 0030012656 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012656	0030012656	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11657
# text = Arrested development: understanding v-abl.
1	Arrested	arrest	ADJ	JJ	Degree=Pos	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_
4	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
5	v-	v-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	abl	abl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11658
# text = The protein tyrosine kinase activity of the v-abl oncogene has been demonstrated to subvert the normal second messenger systems used by lymphoid cells for growth and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
10	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	subvert	subvert	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
19	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
20	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
21	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11659
# text = Transformation of bone marrow with the Abelson murine leukemia virus results in the appearance of B cell lineage cells arrested at the pre-B cell stage.
1	Transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
4	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Abelson	Abelson	PROPN	NNP	Number=Sing	_	_	_	_
8	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
9	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	results	result	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	arrested	arrest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
24	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11660
# text = Recent reports have characterized these cells expressing high v-abl kinase activity as deficient in detectable NF-kappaB
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	abl	abl	ADJ	JJ	Degree=Pos	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 11661
# text = DNA binding activity and low level RAG gene expression.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	RAG	rag	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11662
# text = These observations suggest that v-abl may be inhibiting the differentiation of B cells by blocking these two crucial elements in the maturation pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	abl	abl	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	inhibiting	inhibit	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
24	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11663
# text = Document 0030012657 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012657	0030012657	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11664
# text = Mechanisms of transactivation by nuclear factor of activated T cells-1.
1	Mechanisms	Mechanism	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11665
# text = Nuclear factor of activated T cells-family proteins (NFAT1/NFATp, NFATc, NFAT3, and NFAT4/NFATx/NFATc3) play a key role in the transcription of cytokine genes and other genes during the immune response.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	NFATc	NFATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	NFAT3	NFAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NFAT4/NFATx	NFAT4/NFATx	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	NFATc3	NFATc3	X	LS	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
36	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
37	during	during	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11666
# text = We have defined the mechanisms of transactivation by NFAT1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	NFAT1	NFAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11667
# text = NFAT1 possesses two transactivation domains whose sequences are not conserved in the other NFAT-family proteins, and a conserved DNA-binding domain that mediates the recruitment of cooperating nuclear transcription factors even when it is expressed in the absence of other regions of the protein.
1	NFAT1	NFAT1	NUM	CD	NumType=Card	_	_	_	_
2	possesses	possess	NOUN	NNS	Number=Plur	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
5	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
6	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
7	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	cooperating	cooperate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	even	even	ADV	RB	_	_	_	_	_
36	when	when	ADV	WRB	PronType=Int	_	_	_	_
37	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
45	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11668
# text = The activity of the NH2-terminal transactivation domain is modulated by an adjacent regulatory region that contains several conserved sequence motifs represented only in the NFAT family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
8	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	conserved	conserved	ADJ	JJ	Degree=Pos	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
22	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
23	represented	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NFAT	NFAT	ADJ	JJ	Degree=Pos	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11669
# text = Our results emphasize the multiple levels at which NFAT-dependent transactivation is regulated, and predict significant differences in the architecture of cooperative transcription complexes containing different NFAT-family proteins.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	emphasize	emphasize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	NFAT	NFAT	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	predict	predict	VERB	VB	VerbForm=Inf	_	_	_	_
18	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
19	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	architecture	architecture	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
27	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
28	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
29	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	family	family	NOUN	NN	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11670
# text = Document 0030012661 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012661	0030012661	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11671
# text = Inhibition of transcription factor Stat1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	Stat1	Stat1	NUM	CD	NumType=Card	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
17	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11672
# text = Activation of T cells results in a cascade of gene activation and subsequent proliferation and differentiation into effector phenotypes.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
14	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
19	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11673
# text = The regulation of transcription factors belonging to the signal transducer and activator of transcription (STAT) family was analyzed in PHA-activated mononuclear cells and in purified T cells activated by cross-linking cell surface CD3.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-linking	-link	NOUN	NN	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
38	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11674
# text = Cell activation resulted in a delayed induction of STAT DNA-binding activity, which was sustained for several days, was composed predominantly of Stat1 and Stat3, and was blocked by cycloheximide and actinomycin D.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	predominantly	predominantly	ADV	RB	_	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Stat1	stat1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	actinomycin	actinomycin	VERB	VB	VerbForm=Inf	_	_	_	_
37	D.	D.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 11675
# text = Increased Stat1 and Stat3 mRNA and protein levels were detected, respectively 4 and 24 h after activation.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	respectively	respectively	ADV	RB	_	_	_	_	_
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	24	24	NUM	CD	NumType=Card	_	_	_	_
16	h	h	NOUN	NN	Number=Sing	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11676
# text = Stimulation of the cAMP signal transduction pathway, which skews cytokine production toward a Th2 pattern, resulted in the preferential suppression of Stat1 activity.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
5	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
6	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	skews	skews	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	toward	toward	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
16	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	preferential	preferential	ADJ	JJ	Degree=Pos	_	_	_	_
22	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Stat1	Stat1	NUM	CD	NumType=Card	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11677
# text = cAMP inhibited the induction of expression of IL-2 receptor components, but did not inhibit IL-4 receptor alpha-chain and CD69 expression or the induction of activator protein 1 transcription factors.
1	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha-	alpha-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	CD69	Cd69	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11678
# text = cAMP signaling inhibited Stat1 at several different levels, including suppression of DNA binding and down-regulation of Stat1 protein and mRNA levels.
1	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
2	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
3	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	Stat1	stat1	NUM	CD	NumType=Card	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
11	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Stat1	stat1	NUM	CD	NumType=Card	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11679
# text = Our results demonstrate the regulation of STAT activity by a signaling pathway that regulates the T cell functional phenotype and is distinct from the cytokine-activated Janus kinase-STAT signaling pathway.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
19	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
32	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
33	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11680
# text = Document 0030012663 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012663	0030012663	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11681
# text = Neutrophil maturation and the role of retinoic acid.
1	Neutrophil	Neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
2	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
8	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11682
# text = Neutrophil maturation occurs in well defined morphological stages that correlate with the acquisition of molecular markers associated with neutrophil function.
1	Neutrophil	Neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
2	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
3	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADV	RB	_	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
8	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	correlate	correlate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	acquisition	acquisition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
20	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11683
# text = A variety of factors are known to play a role in terminal neutrophil maturation, including the vitamin A derivative, retinoic acid.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
13	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
14	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
19	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
23	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11684
# text = Retinoic acid can directly modulate gene expression via binding to its nuclear receptors, which can, in turn, activate transcription of target genes.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	directly	directly	ADV	RB	_	_	_	_	_
5	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	via	via	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	target	target	NOUN	NN	Number=Sing	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11685
# text = A role for retinoic acid during neutrophil maturation has been suggested from a variety of sources.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
8	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	sources	source	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11686
# text = Here we present a review of the mechanism of retinoic acid receptor action and the major evidence showing that normal retinoid signaling is required for neutrophil maturation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	present	present	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	review	review	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
11	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	action	action	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
18	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	retinoid	retinoid	NOUN	NN	Number=Sing	_	_	_	_
22	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
27	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11687
# text = Document 0030012665 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012665	0030012665	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11688
# text = Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Ca2+/	ca2+/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	calmodulin	calmodulin	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	IV	iv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11689
# text = The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	+/calmodulin-dependent	+/calmodulin-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	CaMK	CaMK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	IV	iv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	selectively	selectively	ADV	RB	_	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	after	after	SCONJ	IN	_	_	_	_	_
23	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
37	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	some	some	DET	DT	_	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
45	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
46	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
47	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
48	events	event	NOUN	NNS	Number=Plur	_	_	_	_
49	that	that	PRON	WDT	PronType=Rel	_	_	_	_
50	follow	follow	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
51	TCR	Tcr	ADJ	JJ	Degree=Pos	_	_	_	_
52	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11690
# text = Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy with T cell mitogens and with the p21ras oncoprotein.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CaMKIV	CaMKIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	_
8	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
32	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11691
# text = CaMKIV/
1	CaMKIV	CaMKIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	_

# sent_id = 11692
# text = Gr signaling is associated with transcriptional activation of c-fos but is independent of p21ras or calcineurin.
1	Gr	Gr	NOUN	NN	Number=Sing	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11693
# text = AP-1 is an integral component of the nuclear factor of activated T cells (NFAT) transcriptional complex, which is required for interleukin 2 gene expression in T cells.
1	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	integral	integral	ADJ	JJ	Degree=Pos	_	_	_	_
7	component	component	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	interleukin	interleukin	ADV	RB	_	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11694
# text = We demonstrate that CaMKIV/Gr reconstitutes the capacity of the cytosolic component of NFAT to direct transcription from NFAT sites in non-T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	CaMKIV	CaMKIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	_
7	reconstitutes	reconstitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
13	component	component	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	direct	direct	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	no	no	DET	DT	_	_	_	_	SpaceAfter=No
24	n-T	n-t	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11695
# text = These results reveal a central role for CaMKIV/Gr as a Ca(2+)-regulated activator of gene transcription in T lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	CaMKIV	CaMKIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	Gr	Gr	PROPN	NNP	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11696
# text = Document 0030012670 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012670	0030012670	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11697
# text = Transactivation of the interleukin-1alpha promoter by human T-cell leukemia virus type I and type II Tax proteins.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	_
19	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11698
# text = Human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of interleukin-1alpha (IL-1alpha).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	constitutively	constitutively	ADV	RB	_	_	_	_	_
19	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
20	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11699
# text = To analyze the mechanisms that lead to the expression of IL-1alpha in HTLV-I-infected cell lines, we studied regulatory regions of the human IL-1alpha promoter involved in activation of the IL-1alpha gene.
1	To	to	PART	TO	_	_	_	_	_
2	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11700
# text = IL-1alpha promoter constructs drive transcription of the chloramphenicol acetyltransferase (CAT) reporter gene in HTLV-I-positive MT-2 cells, which constitutively produce IL-1alpha.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
6	drive	drive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	MT	mt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	constitutively	constitutively	ADV	RB	_	_	_	_	_
30	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	IL	il	ADV	RB	_	_	_	_	SpaceAfter=No
32	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11701
# text = In a cotransfection assay, the Tax protein of both HTLV-I and HTLV-II specifically activated transcription from the IL-1alpha promoter in an uninfected Jurkat cell line.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	II	II	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	specifically	specifically	ADV	RB	_	_	_	_	_
19	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11702
# text = A mutant Tax protein deficient in transactivation of genes by the nuclear factor (NF)-kappaB pathway was unable to induce transcriptional activity of IL-1alpha promoter-CAT constructs, but was rescued by exogenous provision of p65/p50 NF-kappaB.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
3	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-1alpha	-1alpha	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
32	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	rescued	rescue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
39	provision	provision	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	p65/p50	p65/p50	NUM	CD	NumType=Card	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11703
# text = We found that two IL-1alpha kappaB-like sites (positions -1,065 to -1,056 and +646 to +655) specifically formed a complex with NF-kappaB-containing nuclear extract from MT-2 cells and that NF-kappaB bound with higher affinity to the 3' NF-kappaB binding site than to the 5' NF-kappaB site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	like	like	SCONJ	IN	_	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1,065	1,065	NUM	CD	NumType=Card	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	-1,056	-1,056	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	+646	+646	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	+655	+655	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	specifically	specifically	ADV	RB	_	_	_	_	_
24	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
33	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
34	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
45	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
48	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	'	'	PUNCT	``	_	_	_	_	_
53	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
56	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
57	site	site	NOUN	NN	Number=Sing	_	_	_	_
58	than	than	ADP	IN	_	_	_	_	_
59	to	to	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	'	's	NOUN	NN	Number=Sing	_	_	_	_
63	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
66	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11704
# text = Moreover, deletion of either 5' or 3' NF-kappaB sites reduced IL-1alpha promoter activity in MT-2 cells and transactivation of the IL-1alpha promoter by exogenous NF-kappaB and Tax in Jurkat cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	either	either	CCONJ	CC	_	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL	IL	ADV	RB	_	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11705
# text = These data suggest a general role for Tax induction of IL-1alpha gene transcription by the NF-kappaB pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11706
# text = Expression of IL-1alpha by HTLV-I productively infected cells may be important in the hypercalcemia, osteolytic bone lesions, neutrophilia, elevation of C-reactive protein, and fever frequently seen in patients with HTLV-I-induced adult T-cell leukemia/lymphoma.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	productively	productively	ADV	RB	_	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	hypercalcemia	hypercalcemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	osteolytic	osteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
22	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	neutrophilia	neutrophilia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	C-	C-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	fever	fever	ADV	RB	_	_	_	_	_
34	frequently	frequently	ADV	RB	_	_	_	_	_
35	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
45	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	leukemia	leukemion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
49	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11707
# text = Document 0030012679 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012679	0030012679	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11708
# text = IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
6	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-1	-1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11709
# text = IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
21	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	relatively	relatively	ADV	RB	_	_	_	_	_
31	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
32	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	12	12	NUM	CD	NumType=Card	_	_	_	_
35	target	target	NOUN	NN	Number=Sing	_	_	_	_
36	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
37	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11710
# text = To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes.
1	To	to	ADP	IN	_	_	_	_	_
2	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
3	clarify	clarify	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	12	12	NUM	CD	NumType=Card	_	_	_	_
11	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	set	set	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	out	out	ADP	RP	_	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	first	first	ADV	RB	_	_	_	_	_
28	by	by	SCONJ	IN	_	_	_	_	_
29	contrasting	contraste	VERB	VBG	VerbForm=Ger	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11711
# text = We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	namely	namely	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	MIP	Mip	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	MIP	Mip	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IFN	Ifn	ADP	IN	_	_	_	_	_
30	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-1	-1	NUM	CD	NumType=Card	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11712
# text = IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses.
1	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IFNs	IFNs	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
17	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11713
# text = We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	_
7	directly	directly	ADV	RB	_	_	_	_	_
8	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	regulates	regulate	VERB	NNS	Number=Plur	_	_	_	_
11	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11714
# text = We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	indirectly	indirectly	ADV	RB	_	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11715
# text = Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	12	12	NUM	CD	NumType=Card	_	_	_	_
10	synergistically	synergistically	ADV	RB	_	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	12	12	NUM	CD	NumType=Card	_	_	_	_
24	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11716
# text = The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT4	STAT4	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	ways	way	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11717
# text = First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA.
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	STAT4	STAT4	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL-	Il-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	second	second	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	STAT4	STAT4	PROPN	NNP	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
35	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11718
# text = In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11719
# text = Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	contributor	contributor	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	12	12	NUM	CD	NumType=Card	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	12	12	NUM	CD	NumType=Card	_	_	_	_
26	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
27	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-/-	-/-	PUNCT	.	_	_	_	_	_
33	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
34	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
46	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11720
# text = Document 0030012688 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012688	0030012688	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11721
# text = USF-related transcription factor, HIV-TF1, stimulates transcription of human immunodeficiency virus-1.
1	USF	USF	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	TF1	TF1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11722
# text = The transcription factor HIV-TF1, which binds to a region about 60 bp upstream from the enhancer of the human immunodeficiency virus-1 (HIV-1), was purified from human B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	TF1	tF1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	about	about	ADP	IN	_	_	_	_	_
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11723
# text = HIV-TF1 had a molecular weight of 39,000.
1	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	TF1	tF1	PROPN	NNP	Number=Sing	_	_	_	_
4	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	39,000	39,000	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11724
# text = Binding of HIV-TF1 to the HIV long terminal repeat (LTR) activated transcription from the HIV promoter in vitro.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	TF1	TF1	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
9	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11725
# text = The HIV-TF1-binding site in HIV LTR was similar to the site recognized by upstream stimulatory factor (USF) in the adenovirus major late promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
11	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
20	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	USF	USF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
28	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
29	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11726
# text = DNA-binding properties of HIV-TF1 suggested that HIV-TF1 might be identical or related to USF.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	TF1	TF1	PROPN	NNP	Number=Sing	_	_	_	_
8	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	TF1	TF1	PROPN	NNP	Number=Sing	_	_	_	_
13	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	USF	USF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11727
# text = Interestingly, treatment of purified HIV-TF1 by phosphatase greatly reduced its DNA-binding activity, suggesting that phosphorylation of HIV-TF1 was essential for DNA binding.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	TF1	tF1	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
11	greatly	greatly	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	DNA	DNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	TF1	TF1	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	SCONJ	IN	_	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11728
# text = The disruption of HIV-TF1-binding site induced a 60% decrease in the level of transcription from the HIV promoter in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	%	%	SYM	NN	Number=Sing	_	_	_	_
14	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11729
# text = These results suggest that HIV-TF1 is involved in transcriptional regulation of HIV-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	TF1	tF1	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11730
# text = Document 0030012693 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012693	0030012693	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11731
# text = An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	+)	+)	SYM	NFP	_	_	_	_	_
13	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
14	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11732
# text = The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	SCONJ	IN	_	_	_	_	_
31	alternatively	alternatively	ADV	RB	_	_	_	_	_
32	mediating	mediating	VERB	VBG	VerbForm=Ger	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	protecting	protect	VERB	VBG	VerbForm=Ger	_	_	_	_
35	against	against	ADP	IN	_	_	_	_	_
36	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11733
# text = However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	+)	+)	SYM	NFP	_	_	_	_	_
14	bone	bone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11734
# text = We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	virtually	virtually	ADV	RB	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	CD34	Cd34	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	+)	+)	PUNCT	-RRB-	_	_	_	_	_
12	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
13	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
27	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
30	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	eg	eg	X	FW	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
42	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
54	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
57	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11735
# text = In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	+)	+)	SYM	NFP	_	_	_	_	_
18	bone	bone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	clonogenic	clonogenic	NOUN	NN	Number=Sing	_	_	_	_
22	function	function	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11736
# text = These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	offer	offer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	insight	insight	ADV	RB	_	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	maintaining	maintain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
29	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
30	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	adjunct	adjunct	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
41	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	_
42	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
43	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
44	approached	approach	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	caution	caution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11737
# text = Document 0030012698 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012698	0030012698	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11738
# text = Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	x	x	SYM	SYM	_	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	L	L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	apoptosis	apoptosis	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	transfectants	transfectant	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11739
# text = Human T-cell leukemia virus type 1 (HTLV-1) Tax is thought to play a pivotal role in immortalization of T cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11740
# text = We have recently shown that the expression of Tax protected the mouse T-cell line CTLL-2 against apoptosis induced by interleukin-2 (IL-2) deprivation and converted its growth from being IL-2 dependent to being IL-2 independent.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
10	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
13	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	CTLL	Ctll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	against	against	ADP	IN	_	_	_	_	_
20	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	converted	convert	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
35	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
36	from	from	SCONJ	IN	_	_	_	_	_
37	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
38	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	_
41	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
42	to	to	SCONJ	IN	_	_	_	_	_
43	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
44	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	2	2	NUM	CD	NumType=Card	_	_	_	_
47	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11741
# text = In this study, we demonstrate that constitutive expression of bcl-xl but not bcl-2, bcl-xs, bak, bad, or bax was associated with apoptosis resistance after IL-2 deprivation in CTLL-2 cells that expressed Tax.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	xl	xl	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	xs	x	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	bak	bak	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	bad	bad	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	bax	bax	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	that	that	PRON	WDT	PronType=Rel	_	_	_	_
46	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11742
# text = Transient-transfection assays showed that bcl-x promoter was transactivated by wild-type Tax.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	bcl	bcl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	x	x	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11743
# text = Similar effects were observed in mutant Tax retaining transactivating ability through NF-kappaB.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	retaining	retain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 11744
# text = Deletion or substitution of a putative NF-kappaB binding site identified in the bcl-x promoter significantly decreased Tax-induced transactivation.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	x	x	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11745
# text = This NF-kappaB-like element was able to form a complex with NF-kappaB family proteins in vitro.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
7	element	element	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11746
# text = Furthermore, Tax-induced transactivation of the bcl-x promoter was also diminished by the mutant IkappaBalpha, which specifically inhibits NF-kappaB activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	x	x	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	specifically	specifically	ADV	RB	_	_	_	_	_
23	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11747
# text = Our findings suggest that constitutive expression of Bcl-x(L) induced by Tax through the NF-kappaB pathway contributes to the inhibition of apoptosis in CTLL-2 cells after IL-2 deprivation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	x	x	SYM	SYM	_	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	L	l	INTJ	UH	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	after	after	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11748
# text = Document 0030012699 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012699	0030012699	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11749
# text = Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein.
1	Reactivation	Reactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Kaposi	Kaposi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	's	's	PART	POS	_	_	_	_	_
5	sarcoma	sarcoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	ORF	ORF	PROPN	NNP	Number=Sing	_	_	_	_
17	50	50	NUM	CD	NumType=Card	_	_	_	_
18	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
25	R	R	PROPN	NNP	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11750
# text = Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), or human herpesvirus 8, is a lymphotropic virus strongly linked to several AIDS-related neoplasms.
1	Kaposi	Kaposi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	's	's	PART	POS	_	_	_	_	_
3	sarcoma	sarcoma	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	KS	KS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	KSHV	KSHV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
17	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	lymphotropic	lymphotropic	ADJ	JJ	Degree=Pos	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
23	strongly	strongly	ADV	RB	_	_	_	_	_
24	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
27	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	neoplasms	neoplasm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11751
# text = The primary reservoir of infection consists of latently infected B lymphocytes and possibly other mononuclear cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	latently	latently	ADV	RB	_	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	possibly	possibly	ADV	RB	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11752
# text = Viral reactivation from latency and spread from this lymphoid reservoir is presumably required for development of nonlymphoid tumors like KS.
1	Viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
2	reactivation	reactivation	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	spread	spread	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
10	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	presumably	presumably	ADV	RB	_	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
19	like	like	ADP	IN	_	_	_	_	_
20	KS	KS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11753
# text = Here we show that deregulated expression of a single viral gene, ORF 50, which encodes a transactivator able to selectively upregulate delayed-early viral genes, suffices to disrupt latency and induce the lytic gene cascade in latently infected B cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	deregulated	deregulated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
10	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	ORF	ORF	PROPN	NNP	Number=Sing	_	_	_	_
14	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
20	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	selectively	selectively	ADV	RB	_	_	_	_	_
23	upregulate	upregulate	VERB	VB	VerbForm=Inf	_	_	_	_
24	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suffices	suffice	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	disrupt	disrupt	VERB	VB	VerbForm=Inf	_	_	_	_
33	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	latently	latently	ADV	RB	_	_	_	_	_
42	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11754
# text = The identification of this gene opens the way to studies of the physiologic mechanisms controlling reactvation of KSHV from latency.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	opens	open	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	way	way	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
16	reactvation	reactvation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	KSHV	KSHV	PROPN	NNP	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11755
# text = Copyright 1998 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1998	1998	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press	Press	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11756
# text = Document 0030012709 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012709	0030012709	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11757
# text = Interleukin-2 promoter activity in Epstein-Barr virus-transformed
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-transformed	-transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 11758
# text = B lymphocytes is controlled by nuclear factor-chi B.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	chi	chi	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11759
# text = The regulation of interleukin (IL)-2 gene expression has been investigated mainly in T lymphocytes, the predominant producers of IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	mainly	mainly	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
22	producers	producer	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11760
# text = However, B cells can also synthesize IL-2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	synthesize	synthesize	VERB	VB	VerbForm=Inf	_	_	_	_
8	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11761
# text = In the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	control	control	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
24	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
31	of	of	SCONJ	IN	_	_	_	_	_
32	secreting	secret	VERB	VBG	VerbForm=Ger	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
39	level	level	NOUN	NN	Number=Sing	_	_	_	_
40	after	after	ADP	IN	_	_	_	_	_
41	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
44	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
47	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	+	+	SYM	SYM	_	_	_	_	_
54	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	_
55	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11762
# text = Transient transfections using reporter constructs with multiples of transcription factor binding sites from the IL-2 promoter [distal nuclear factor (NF)-AT, proximal NF-AT, AP-1/Octamer (UPS) or NF-chi B (TCEd) sites] were performed.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfections	transfection	NOUN	NNS	Number=Plur	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	multiples	multiple	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	AT	at	ADV	RB	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	AT	AT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Octamer	Octamer	PROPN	NNP	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	UPS	ups	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	chi	chi	PROPN	NNP	Number=Sing	_	_	_	_
46	B	b	PROPN	NNP	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	TCEd	TCEd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	]	]	PUNCT	-RRB-	_	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11763
# text = In EBV-transformed B clones, the chi B site exerted the strongest inducible activity; the NF-AT binding sites showed either no or only weak activity compared to Jurkat T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	chi	chi	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	exerted	exert	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	strongest	strongest	ADJ	JJS	Degree=Sup	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	;	;	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	AT	at	SCONJ	IN	_	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	either	either	CCONJ	CC	_	_	_	_	_
26	no	no	DET	DT	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
34	T	T	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11764
# text = An IL-2 promoter bearing a defective NF-chi B site was completely inactive in EBV-transformed B cells, while it still had activity in Jurkat T cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	chi	chi	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	completely	completely	ADV	RB	_	_	_	_	_
16	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	while	while	SCONJ	IN	_	_	_	_	_
25	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	still	still	ADV	RB	_	_	_	_	_
27	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11765
# text = In seven EBV-B cell clones or lines differing in their capacity to secrete IL-2, the activity of the IL-2 promoter correlated well with the status of IL-2 secretion.
1	In	in	ADP	IN	_	_	_	_	_
2	seven	seven	NUM	CD	NumType=Card	_	_	_	_
3	EBV	Ebv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	differing	differ	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	secrete	secrete	VERB	VB	VerbForm=Inf	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	status	status	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11766
# text = Similarly, a human immunodeficiency virus promoter, whose activity is controlled through chi B factors, was found to be active in the IL-2 producing EBV-B cells, but inactive in the non-IL-2-producing cells.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	chi	chi	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
29	EBV	Ebv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	non-IL	non-il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11767
# text = Electrophoretic mobility shift assays using protein extracts from EBV-B cells and the IL-2 NF-chi B probe revealed the constitutive generation of chi B complexes in IL-2-secreting cells consisting mainly of heterodimeric p50/p65 complexes.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	chi	chi	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	probe	probe	ADV	RB	_	_	_	_	_
23	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
26	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	chi	chi	ADJ	JJ	Degree=Pos	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	secreting	secreting	VERB	VBG	VerbForm=Ger	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	consisting	consist	VERB	VBG	VerbForm=Ger	_	_	_	_
39	mainly	mainly	ADV	RB	_	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
42	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
45	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11768
# text = A weaker chi B complex formation and faster-migrating complexes were detected in non-IL-2-secreting cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	weaker	weaker	NOUN	NN	Number=Sing	_	_	_	_
3	chi	chi	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	faster	faster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	non-IL	non-il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	secreting	secreting	VERB	VBG	VerbForm=Ger	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11769
# text = These results demonstrate that the IL-2 NF-chi B site is indispensable for the activity of the IL-2 promoter in EBV-transformed B cells, whereas other transcription factors appear to be less important for IL-2 expression in these cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	chi	chi	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	indispensable	indispensable	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	whereas	whereas	SCONJ	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
36	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
39	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
40	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11770
# text = Document 0030012712 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012712	0030012712	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11771
# text = Prostaglandin E2
1	Prostaglandin	Prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
2	E2	E2	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 11772
# text = Up-regulates HIV-1 long terminal repeat-driven gene activity in T cells via NF-kappaB-dependent and -independent signaling pathways.
1	Up-	Up-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
26	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11773
# text = Replication of human immunodeficiency virus type-1 (HIV-1) is highly dependent on the state of activation of the infected cells and is modulated by interactions between viral and host cellular factors.
1	Replication	Replication	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	highly	highly	ADV	RB	_	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	state	state	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	host	host	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11774
# text = Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, is observed at elevated levels during HIV-1 infection as well as during the course of other pathogenic infections.
1	Prostaglandin	Prostaglandin	PROPN	NNP	Number=Sing	_	_	_	_
2	E2	E2	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	course	course	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
31	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11775
# text = In 1G5, a Jurkat-derived T cell line stably transfected with a luciferase gene driven by HIV-1 long terminal repeat (LTR), we found that PGE2 markedly enhanced HIV-1 LTR-mediated reporter gene activity.
1	In	in	ADP	IN	_	_	_	_	_
2	1G5	1G5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	stably	stably	ADV	RB	_	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
30	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	_
33	markedly	markedly	ADV	RB	_	_	_	_	_
34	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11776
# text = Experiments have been conducted to identify second messengers involved in this PGE2-dependent up-regulating effect on the regulatory element of HIV-1.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
7	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11777
# text = In this study, we present evidence indicating that signal transduction pathways induced by PGE2 necessitate the participation of cyclic AMP, protein kinase A, and Ca2+.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	PGE2	Pge2	NUM	CD	NumType=Card	_	_	_	_
16	necessitate	necessitate	NOUN	NN	Number=Sing	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
21	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11778
# text = Experiments conducted with different HIV-1 LTR-based vectors suggested that PGE2-mediated activation effect on HIV-1 transcription was transduced via both NF-kappaB-dependent and -independent signaling pathways.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
12	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	PGE2	Pge2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	via	via	ADP	IN	_	_	_	_	_
27	both	both	DET	DT	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
36	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
37	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11779
# text = The involvement of NF-kappaB in the PGE2-dependent activating effect on HIV-1 transcription was further confirmed using a kappaB-regulated luciferase encoding vector and by electrophoretic mobility shift assays.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	activating	activate	NOUN	NN	Number=Sing	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	further	further	ADV	RB	_	_	_	_	_
21	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
28	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
29	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
33	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
34	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
35	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11780
# text = Results from Northern blot and flow cytometric analyses, as well as the use of a selective antagonist indicated that PGE2 modulation of HIV-1 LTR-driven reporter gene activity in studied T lymphoid cells is transduced via the EP4 receptor subtype.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
4	blot	blot	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	flow	flow	VERB	VB	VerbForm=Inf	_	_	_	_
7	cytometric	cytometric	ADJ	JJ	Degree=Pos	_	_	_	_
8	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	use	use	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
18	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
19	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
22	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	T	T	PROPN	NNP	Number=Sing	_	_	_	_
35	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	via	via	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	EP4	EP4	PROPN	NNP	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	subtype	subtype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11781
# text = These results suggest that secretion of PGE2 by macrophages in response to infection or inflammatory activators could induce signaling events resulting in activation of proviral DNA present into T cells latently infected with HIV-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
20	events	event	NOUN	NNS	Number=Plur	_	_	_	_
21	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	into	into	ADP	IN	_	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	latently	latently	ADV	RB	_	_	_	_	_
32	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11782
# text = Document 0030012716 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012716	0030012716	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11783
# text = Suppression of signals required for activation of transcription factor NF-kappa B in cells constitutively expressing the HTLV-I Tax protein.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	constitutively	constitutively	ADV	RB	_	_	_	_	_
17	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11784
# text = Transient short-term expression of the Tax protein of human T-cell leukemia virus type-I (HTLV-I) leads to activation of the pleiotropic transcription factor NF-kappa B. Consistent with findings obtained with transient expression assays, we observed marked accumulation of the transcription factor NF-kappa B in the nucleus of Namalwa B lymphoid cells, which constitutively express Tax.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	term	term	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
36	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
39	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
43	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
46	observed	observe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
53	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
56	B	b	NOUN	NN	Number=Sing	_	_	_	_
57	in	in	ADP	IN	_	_	_	_	_
58	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
59	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	Namalwa	Namalwa	PROPN	NNP	Number=Sing	_	_	_	_
62	B	B	PROPN	NNP	Number=Sing	_	_	_	_
63	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
64	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
65	,	,	PUNCT	,	_	_	_	_	_
66	which	which	PRON	WDT	PronType=Rel	_	_	_	_
67	constitutively	constitutively	ADV	RB	_	_	_	_	_
68	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
69	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11785
# text = In contrast, NF-kappa B activity was not detected in the nucleus following long-term expression of Tax in Jurkat T lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	term	term	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11786
# text = The ability of both mitogens and cytokines to activate NF-kappa B was also blocked in Jurkat cells constitutively expressing Tax.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	constitutively	constitutively	ADV	RB	_	_	_	_	_
21	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
22	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11787
# text = However, the activation of other mitogen-inducible transcription factors, such as Fos and Jun, was unaffected.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11788
# text = Thus, depending on the cellular environment, the short- and long-term effects of Tax expression can be quite different.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	environment	environment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	term	term	NOUN	NN	Number=Sing	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	quite	quite	ADV	RB	_	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11789
# text = Consequently, one function of Tax in cells infected with HTLV-I might involve cell-type-specific suppression, as opposed to activation, of distinct signal pathways.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
15	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
16	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	type-	type-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	opposed	oppose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
30	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11790
# text = The cells lines described here should be useful for the delineation of signaling pathways utilized in the selective regulation of gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	here	here	ADV	RB	PronType=Dem	_	_	_	_
6	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	delineation	delineation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11791
# text = Document 0030012719 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012719	0030012719	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11792
# text = Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers.
1	Upregulation	Upregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
13	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	delayed	delay	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	relative	relative	ADV	RB	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
39	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11793
# text = An ability of the Epstein-Barr virus latent membrane protein LMP1 to enhance the survival of infected B cells through upregulation of the bcl-2 oncogene was first suggested by experiments involving gene transfection and the selection of stable LMP1+ clones (S.Henderson, M. Rowe, C.Gregory, F.Wang, E.Kieff, and A.Rickinson, Cell 65:1107-1115, 1991).
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
12	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	first	first	ADV	RB	_	_	_	_	_
31	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
34	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
35	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
36	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
42	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	+	+	SYM	SYM	_	_	_	_	_
44	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	S.Henderson	S.Henderson	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
49	Rowe	Rowe	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	C.Gregory	C.Gregory	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	F.Wang	F.Wang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	E.Kieff	E.Kieff	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	A.Rickinson	A.Rickinson	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
61	65:1107-1115	65:1107-1115	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	1991	1991	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11794
# text = However, it was not possible to ascertain whether Bcl-2 upregulation was a specific consequence of LMP1 expression or an artifact of the selection procedure whereby rare Bcl-2+ cells already present in the starting population might best be able to tolerate the potentially toxic effects of LMP1.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	ascertain	ascertain	VERB	VB	VerbForm=Inf	_	_	_	_
9	whether	whether	SCONJ	IN	_	_	_	_	_
10	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	artifact	artifact	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
27	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	_
28	whereby	whereby	ADP	IN	_	_	_	_	_
29	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
30	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	+	+	SYM	SYM	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	already	already	ADV	RB	_	_	_	_	_
36	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	starting	starting	NOUN	NN	Number=Sing	_	_	_	_
40	population	population	NOUN	NN	Number=Sing	_	_	_	_
41	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
42	best	best	ADV	RBS	Degree=Sup	_	_	_	_
43	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
44	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	tolerate	tolerate	VERB	VB	VerbForm=Inf	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	potentially	potentially	ADV	RB	_	_	_	_	_
49	toxic	toxic	ADJ	JJ	Degree=Pos	_	_	_	_
50	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11795
# text = We therefore reexamined this issue by using two different experimental approaches that allowed LMP1- induced effects to be monitored immediately following expression of the viral protein and in the absence of selective pressures; activation of the NF-kappa B transcription factor and upregulation of the cell adhesion molecule ICAM-1 were used as early indices of LMP1 function.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	reexamined	reexamin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	issue	issue	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
11	approaches	approache	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	immediately	immediately	ADV	RB	_	_	_	_	_
22	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
34	pressures	pressure	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
51	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
52	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	1	1	NUM	CD	NumType=Card	_	_	_	_
55	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
56	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	as	as	ADP	IN	_	_	_	_	_
58	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
59	indices	index	NOUN	NNS	Number=Plur	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
62	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11796
# text = In the first approach, stable clones of two B-cell lines carrying an LMP1 gene under the control of an inducible metallothionein promoter were induced to express LMP1 in all cells.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
4	approach	approach	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
7	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
14	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	LMP1	LMP1	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	under	under	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	metallothionein	metallothionein	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
30	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	all	all	DET	DT	_	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11797
# text = Activation of NK-kappa B and upregulation of ICAM-1 occurred within 24 h and were followed at 48 to 72 h by upregulation of Bcl-2.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	24	24	NUM	CD	NumType=Card	_	_	_	_
16	h	h	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	48	48	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	72	72	NUM	CD	NumType=Card	_	_	_	_
24	h	h	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11798
# text = In the second approach, we tested the generality of this phenomenon by transiently expressing LMP1 from a strong constitutively active promoter in a range of different cell types.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
4	approach	approach	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	generality	generality	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	transiently	transiently	ADV	RB	_	_	_	_	_
15	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
16	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
20	constitutively	constitutively	ADV	RB	_	_	_	_	_
21	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	range	range	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11799
# text = All six B-cell lines tested showed NF-kappa B activation in response to LMP1 expression, and this was followed in five of six lines by expression of ICAM-1 and Bcl-2.
1	All	all	DET	PDT	_	_	_	_	_
2	six	six	NUM	CD	NumType=Card	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	showed	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	five	five	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	six	six	NUM	CD	NumType=Card	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	ICAM	ICAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11800
# text = In the same experiments, all three non-B-cell lines showed NF-kappa B activation and ICAM-1 upregulation but never any effect upon Bcl-2.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	non	non	X	AFX	_	_	_	_	SpaceAfter=No
9	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	never	never	ADV	RB	_	_	_	_	_
26	any	any	DET	DT	_	_	_	_	_
27	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
28	upon	upon	ADP	IN	_	_	_	_	_
29	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11801
# text = We therefore conclude that Bcl-2 upregulation is part of the panoply of cellular changes induced by LMP1 but that the effect is cell type specific.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	part	part	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	panoply	panoply	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	type	type	NOUN	NN	Number=Sing	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11802
# text = Our data also suggest that whilst NF-kappa B may be an essential component of LMP1 signal transduction, other cell-specific factors may be required to effect some functions of the viral protein.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	whilst	whilst	SCONJ	IN	_	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	effect	effect	VERB	VB	VerbForm=Inf	_	_	_	_
31	some	some	DET	DT	_	_	_	_	_
32	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11803
# text = Document 0030012722 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012722	0030012722	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11804
# text = Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
17	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11805
# text = HIV-1 proviral DNA contains two binding sites for the transcription factor NF-kappa B. HIV-1-infected individuals have, on average, abnormally high levels of tumour necrosis factor alpha (TNF alpha) and abnormally low plasma cysteine levels.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-infected	-infected	ADJ	JJ	Degree=Pos	_	_	_	_
23	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
24	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	average	average	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	abnormally	abnormally	ADV	RB	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
34	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	abnormally	abnormally	ADV	RB	_	_	_	_	_
43	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
44	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
45	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
46	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11806
# text = We therefore investigated the effects of cysteine and related thiols on HIV-1 replication and NF-kappa B expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	thiols	thiol	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11807
# text = The experiments in this report show that cysteine or N-acetylcysteine (NAC) raise the intracellular glutathione (GSH) level and inhibit HIV-1 replication in persistently infected Molt-4 and U937 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	raise	raise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GSH	GSH	INTJ	UH	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	persistently	persistently	ADV	RB	_	_	_	_	_
31	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	Molt	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	4	4	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	U937	U937	NUM	CD	NumType=Card	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11808
# text = However, inhibition of HIV-1 replication appears not to be directly correlated with GSH levels.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	directly	directly	ADV	RB	_	_	_	_	_
14	correlated	correlated	ADJ	JJ	Degree=Pos	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	GSH	Gsh	DET	DT	_	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11809
# text = Cysteine and NAC also inhibit NF-kappa B activity as determined by electrophoretic mobility shift assays and chloramphenicol acetyl-transferase (CAT) gene expression under control of NF-kappa B binding sites in uninfected cells.
1	Cysteine	Cysteine	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	SCONJ	IN	_	_	_	_	_
12	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
15	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
20	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	under	under	ADP	IN	_	_	_	_	_
29	control	control	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11810
# text = This suggests that the cysteine deficiency in HIV-1-infected individuals may cause an over-expression of NF-kappa B-dependent genes and enhance HIV-1 replication.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	_
6	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-infected	-infect	ADJ	JJ	Degree=Pos	_	_	_	_
12	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	over-expression	over-expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	enhance	enhance	NOUN	NN	Number=Sing	_	_	_	_
27	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11811
# text = NAC may be considered for the treatment of HIV-1-infected individuals.
1	NAC	Nac	PROPN	NNP	Number=Sing	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11812
# text = Document 0030012723 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012723	0030012723	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11813
# text = Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
10	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11814
# text = This study examined the effects of leukemia inhibitory factor (LIF) on human immunodeficiency virus (HIV) replication in mononuclear phagocytes (MNP).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LIF	LIF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	MNP	MNP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11815
# text = LIF induced a dose-dependent increase in p24 antigen production in the chronically infected promonocytic cell line U1. The magnitude and time kinetics of the LIF effects were similar to interleukin 1 (IL-1), IL-6, and tumor necrosis factor (TNF), other cytokines known to induce HIV replication in this cell line.
1	LIF	LIF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	p24	p24	NUM	CD	NumType=Card	_	_	_	_
10	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	chronically	chronically	ADV	RB	_	_	_	_	_
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	U1	u1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_
21	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	_
25	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	LIF	Lif	PROPN	NNP	Number=Sing	_	_	_	_
29	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
47	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
48	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
54	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
55	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	to	to	ADP	IN	_	_	_	_	_
57	induce	induce	PROPN	NNP	Number=Sing	_	_	_	_
58	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
59	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
60	in	in	ADP	IN	_	_	_	_	_
61	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
62	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
63	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11816
# text = To characterize mechanisms responsible for these LIF effects, levels of HIV mRNA, activation of the DNA binding protein nuclear factor (NF)-kB, signal transduction pathways, and potential interactions with other cytokines were analyzed.
1	To	to	ADP	IN	_	_	_	_	_
2	characterize	characterize	NOUN	NN	Number=Sing	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	LIF	Lif	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	protein	protein	ADV	RB	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
27	kB	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
30	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
35	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
38	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11817
# text = LIF increased steady-state levels of HIV mRNA at 2.0, 4.3, and 9.2 kB.
1	LIF	Lif	AUX	VB	VerbForm=Inf	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	state	state	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	2.0	2.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	4.3	4.3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	9.2	9.2	NUM	CD	NumType=Card	_	_	_	_
17	kB	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11818
# text = This was detectable by 24 h and persisted until 72 h.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	24	24	NUM	CD	NumType=Card	_	_	_	_
6	h	h	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	persisted	persist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	until	until	ADP	IN	_	_	_	_	_
10	72	72	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11819
# text = The DNA binding protein NF-kB is a central mediator in cytokine activation of HIV transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11820
# text = NF-kB
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 11821
# text = levels were higher in unstimulated U1 cells as compared to the parent cell line U937.
1	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
6	U1	U1	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	parent	parent	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11822
# text = In both cell lines LIF increased NF-kB activity.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	LIF	Lif	PROPN	NNP	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11823
# text = Induction of NF-kB and HIV replication by cytokines are at least in part dependent on reactive oxygen intermediates.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	part	part	ADJ	JJ	Degree=Pos	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
20	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11824
# text = The oxygen radical scavenger N-acetyl-L-cysteine, but not an inhibitor of nitric oxide synthase, inhibited LIF-induced HIV replication.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
3	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
4	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
5	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-L	-l	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
17	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
18	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	LIF	LIF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
25	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11825
# text = LIF induces the production of other cytokines in monocytes but its effects on HIV replication were not inhibited by antibodies to IL-1, TNF, or IL-6.
1	LIF	LIF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	effects	effect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11826
# text = These results identify LIF as a stimulus of HIV replication.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	LIF	LIF	ADP	RP	_	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
10	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11827
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11828
# text = Document 0030012733 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012733	0030012733	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11829
# text = NF-kappa B-dependent induction of the NF-kappa B p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	underlies	underly	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	perpetuation	perpetuation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11830
# text = The molecular mechanisms underlying the sustained nuclear translocation of NF-kappa B observed in U937 monocytic cells chronically infected with human immunodeficiency virus (HIV) were studied.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
4	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	U937	U937	NUM	CD	NumType=Card	_	_	_	_
17	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	chronically	chronically	ADV	RB	_	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11831
# text = The activity of the promoter regulating the synthesis of the p105 precursor of the NF-kappa B p50 subunit was enhanced in these cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	p50	p50	NUM	CD	NumType=Card	_	_	_	_
20	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11832
# text = Deletions in this promoter indicated that this upregulation was mediated through the NF-kappa B- but not the AP-1-binding motif, by bona fide p50/p65 heterodimers.
1	Deletions	Deletion	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	bona	bona	NOUN	NN	Number=Sing	_	_	_	_
30	fide	fide	NOUN	NN	Number=Sing	_	_	_	_
31	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
34	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11833
# text = Analysis of cytosolic extracts indicated that NF-kappa B levels were increased in HIV-infected cells.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11834
# text = In contrast to the transient NF-kappa B activation induced by phorbol ester, the permanent NF-kappa B translocation induced by HIV infection was not dependent on PKC isoenzymes alpha and beta as shown by the use of a specific inhibitor (GF 109203X).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
14	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	PKC	Pkc	ADJ	JJ	Degree=Pos	_	_	_	_
32	isoenzymes	isoenzyme	NOUN	NNS	Number=Plur	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	as	as	SCONJ	IN	_	_	_	_	_
37	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	use	use	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
44	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	GF	gf	PROPN	NNP	Number=Sing	_	_	_	_
47	109203	109203	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11835
# text = These observations indicate that during chronic HIV infection of U937 cells, continuous NF-kappa B (p50/p65) translocation results in p105 promoter upregulation with subsequent cytosolic NF-kappa B accumulation, ready for further translocation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	U937	U937	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
21	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
24	results	result	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	p105	p105	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	ready	ready	ADJ	JJ	Degree=Pos	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
41	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11836
# text = This HIV-mediated mechanism results in a self-perpetuating loop of NF-kappa B production.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	perpetuating	perpetuat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11837
# text = Document 0030012734 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012734	0030012734	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11838
# text = Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
5	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	p27Kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11839
# text = The cyclin-dependent kinase inhibitor p27Kip1 plays an important role in regulating cell-cycle progression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	p27Kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
17	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11840
# text = p27Kip1
1	p27Kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 11841
# text = directly inhibits the catalytic activity of cyclin/cdks (cyclin-dependent kinase) complexes and/or interferes physically with cyclin/cdks activation by CAK.
1	directly	directly	ADV	RB	_	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	cdks	cdk	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	or	or	CCONJ	CC	_	_	_	_	_
20	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	physically	physically	ADV	RB	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	cdks	cdk	NOUN	NNS	Number=Plur	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	CAK	CAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11842
# text = Interestingly, the expression level of p27Kip1 mRNA was maximal in resting Go T-cells and rapidly declined following anti-CD3 activation.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	level	level	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p27Kip1	p27Kip1	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	Go	go	PROPN	NNP	Number=Sing	_	_	_	_
14	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
20	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11843
# text = We report here the cloning of p27Kip1 gene from murine genomic DNA and the functional analysis of the promoter of the p27Kip1 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p27Kip1	p27Kip1	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	murine	murine	PRON	PRP	_	_	_	_	_
11	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
16	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p27Kip1	p27kip1	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11844
# text = The gene consists of at least three exons and spans more than 5.6 kb of DNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	at	at	ADV	RB	_	_	_	_	_
6	least	least	ADV	RBS	Degree=Sup	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	spans	span	NOUN	NNS	Number=Plur	_	_	_	_
11	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
12	than	than	ADP	IN	_	_	_	_	_
13	5.6	5.6	NUM	CD	NumType=Card	_	_	_	_
14	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11845
# text = Primer extension and nuclease S1 protection analysis revealed two major transcription initiation sites.
1	Primer	Primer	NOUN	NN	Number=Sing	_	_	_	_
2	extension	extension	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	nuclease	nuclease	NOUN	NN	Number=Sing	_	_	_	_
5	S1	s1	NOUN	NN	Number=Sing	_	_	_	_
6	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11846
# text = The promoter region lacked a TATA box but contained potential binding sites for the transcriptional factors including two Sp1, CRE, Myb and NFkB located at positions -153, -178, -286, -875, and -1011, respectively.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NFkB	NFkB	PROPN	NNP	Number=Sing	_	_	_	_
26	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
29	-153	-153	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	178	178	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	-286	-286	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	875	875	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	1011	1011	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11847
# text = To analyze the regulatory mechanisms controlling p27Kip1 gene expression, we characterized the 5'-flanking region from nt -1609 to +178. The -326 to -615 region contained positive regulatory elements.
1	To	to	PART	TO	_	_	_	_	_
2	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
7	p27Kip1	p27kip1	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	nt	not	PART	RB	_	_	_	_	_
21	-1609	-1609	NUM	CD	NumType=Card	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
24	178	178	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_
26	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	-326	-326	NUM	CD	NumType=Card	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	615	615	NUM	CD	NumType=Card	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11848
# text = Document 0030012736 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012736	0030012736	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11849
# text = CTLA-4-Mediated inhibition of early events of T cell proliferation.
1	CTLA	CTLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-Mediated	-Mediated	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11850
# text = CTLA-4 engagement by mAbs inhibits, while CD28 enhances, IL-2 production and proliferation upon T cell activation.
1	CTLA	CTLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	mAbs	mAbs	NOUN	NNS	Number=Plur	_	_	_	_
7	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	while	while	SCONJ	IN	_	_	_	_	_
10	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
11	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
19	upon	upon	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11851
# text = Here, we have analyzed the mechanisms involved in CTLA-4-mediated inhibition of T cell activation of naive CD4+ T cells using
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	CTLA	CTLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
22	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	+	+	SYM	SYM	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 11852
# text = Ab cross-linking.
1	Ab	Ab	ADV	RB	_	_	_	_	_
2	cross	cross	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11853
# text = CTLA-4 ligation inhibited CD3/CD28-induced IL-2 mRNA accumulation by inhibiting IL-2 transcription, which appears to be mediated in part through decreasing NF-AT accumulation in the nuclei.
1	CTLA	CTLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	CD3/CD28-induced	CD3/CD28-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	part	part	NOUN	NN	Number=Sing	_	_	_	_
26	through	through	SCONJ	IN	_	_	_	_	_
27	decreasing	decrease	VERB	VBG	VerbForm=Ger	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
31	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11854
# text = However, CTLA-4 ligation did not appear to affect the CD28-mediated stabilization of IL-2 mRNA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CTLA	CTLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11855
# text = Further, CTLA-4 engagement inhibited progression through the cell cycle by inhibiting the production of cyclin D3, cyclin-dependent kinase (cdk)4, and cdk6 when the T cells were stimulated with anti-CD3/CD28 and with anti-CD3 alone.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CTLA	CTLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
19	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	cdk	cdk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	cdk6	cdk6	NUM	CD	NumType=Card	_	_	_	_
32	when	when	ADV	WRB	PronType=Int	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	anti-CD3/CD28	anti-CD3/CD28	NUM	CD	NumType=Card	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
43	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11856
# text = These results indicate that CTLA-4 signaling inhibits events early in T cell activation both at IL-2 transcription and at the level of IL-2-independent events of the cell cycle, and does not simply oppose CD28-mediated costimulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CTLA	CTLa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
9	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
10	events	event	NOUN	NNS	Number=Plur	_	_	_	_
11	early	early	ADV	RB	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	level	level	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
32	events	event	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	not	not	PART	RB	_	_	_	_	_
41	simply	simply	ADV	RB	_	_	_	_	_
42	oppose	oppose	VERB	VB	VerbForm=Inf	_	_	_	_
43	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-mediated	-mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11857
# text = Document 0030012739 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012739	0030012739	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11858
# text = oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.
1	oriP	orip	SYM	NFP	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
7	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-immortalized	-immortalize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11859
# text = During Epstein-Barr virus latent infection of B lymphocytes in vitro, six viral nuclear antigens (EBNAs) are expressed from one of two promoters, Cp or
1	During	during	ADP	IN	_	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	six	six	NUM	CD	NumType=Card	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	EBNAs	EBNAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	one	one	NUM	CD	NumType=Card	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	two	two	NUM	CD	NumType=Card	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_

# sent_id = 11860
# text = Wp, whose activities are mutually exclusive.
1	Wp	Wp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
4	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	mutually	mutually	ADV	RB	_	_	_	_	_
7	exclusive	exclusive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11861
# text = Upon infection,
1	Upon	upon	ADP	IN	_	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_

# sent_id = 11862
# text = Wp is initially active, followed by a switch to Cp for the duration of latency.
1	Wp	Wp	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	initially	initially	ADV	RB	_	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	Cp	cp	VERB	VB	VerbForm=Inf	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11863
# text = In this study, the region upstream of Cp was analyzed for the presence of cis elements involved in regulating the activities of the EBNA gene promoters in established in vitro immortalized lymphoblastoid cell lines (LCLs).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cis	cis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	SCONJ	IN	_	_	_	_	_
20	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
32	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	LCLs	LCL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11864
# text = It was determined that oriP, the origin for episomal maintenance during latency, is essential for efficient transcription initiation from either Cp or
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	oriP	orip	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	episomal	episomal	ADJ	JJ	Degree=Pos	_	_	_	_
11	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	either	either	CCONJ	CC	_	_	_	_	_
23	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_

# sent_id = 11865
# text = Wp in LCLs, as well as in some Burkitt's lymphoma cell lines.
1	Wp	Wp	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	LCLs	LCLs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	as	as	ADV	RB	_	_	_	_	_
6	well	well	ADV	RB	Degree=Pos	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	some	some	DET	DT	_	_	_	_	_
10	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	's	's	PART	POS	_	_	_	_	_
12	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11866
# text = Deletion of the EBNA2-dependent enhancer located upstream of Cp resulted in a ca.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	EBNA2	EBNA2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
12	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11867
# text = two- to fivefold reduction in Cp activity in the LCLs assayed.
1	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	fivefold	fivefold	VERB	VB	VerbForm=Inf	_	_	_	_
5	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Cp	cp	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	LCLs	LCLs	NOUN	NNS	Number=Plur	_	_	_	_
12	assayed	assay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11868
# text = More extensive deletion of sequences upstream of Cp, including the EBNA2-dependent enhancer, resulted in nearly complete loss of Cp activity.
1	More	more	ADV	RBR	_	_	_	_	_
2	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
6	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EBNA2	Ebna2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	nearly	nearly	ADV	RB	_	_	_	_	_
20	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
21	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Cp	cp	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11869
# text = This loss of activity was shown to correlate with deletion of two CCAAT boxes, a proximal CCAAT box located at bp -61 to -65 and a distal CCAAT box located at bp -253 to -257, upstream of Cp. Site-directed mutagenesis of these cis elements demonstrated that Cp activity is highly dependent on the presence of a properly positioned CCAAT box, with the dependence on the distal CCAAT box apparent only when the proximal CCAAT box was deleted or mutated.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
14	boxes	box	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
19	box	box	NOUN	NN	Number=Sing	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	61	61	NUM	CD	NumType=Card	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	-65	-65	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
30	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
31	box	box	NOUN	NN	Number=Sing	_	_	_	_
32	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	253	253	NUM	CD	NumType=Card	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	257	257	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_
45	Site-	Site-	SYM	NFP	_	_	_	_	SpaceAfter=No
46	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
50	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
51	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
52	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
54	Cp	cp	NOUN	NN	Number=Sing	_	_	_	_
55	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
56	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
57	highly	highly	ADV	RB	_	_	_	_	_
58	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
59	on	on	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
64	properly	properly	ADV	RB	_	_	_	_	_
65	positioned	position	ADJ	JJ	Degree=Pos	_	_	_	_
66	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
67	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	with	with	ADP	IN	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
72	on	on	ADP	IN	_	_	_	_	_
73	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
74	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
75	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
76	box	box	NOUN	NN	Number=Sing	_	_	_	_
77	apparent	apparent	NOUN	NN	Number=Sing	_	_	_	_
78	only	only	ADV	RB	_	_	_	_	_
79	when	when	ADV	WRB	PronType=Int	_	_	_	_
80	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
81	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
82	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	_
83	box	box	NOUN	NN	Number=Sing	_	_	_	_
84	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
85	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
86	or	or	CCONJ	CC	_	_	_	_	_
87	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
88	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11870
# text = Deletion of the glucocorticoid response elements located at ca. bp -850 upstream of Cp did not result in a significant loss in activity.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
7	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	ca	ca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	850	850	NUM	CD	NumType=Card	_	_	_	_
14	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
23	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11871
# text = In general, deletions which diminished Cp activity resulted in induction of Wp activity, consistent with suppression of Wp activity by transcriptional interference from Cp.
1	In	in	ADP	IN	_	_	_	_	_
2	general	general	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Wp	Wp	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Wp	Wp	PROPN	NNP	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11872
# text = The identification of oriP and the EBNA2-dependent enhancer as the major positive cis elements involved in regulating Cp activity in LCL suggests that EBNA gene transcription is largely autoregulated by EBNA 1 and EBNA 2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	oriP	oriP	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	EBNA2	Ebna2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
16	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
17	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	Cp	cp	PROPN	NNP	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	LCL	LCL	PROPN	NNP	Number=Sing	_	_	_	_
24	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	largely	largely	ADV	RB	_	_	_	_	_
31	autoregulated	autoregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	_
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11873
# text = Document 0030012741 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012741	0030012741	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11874
# text = Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
23	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RE	re	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11875
# text = IL-2 gene transcription in T cells requires both TCR and costimulatory signals.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	TCR	Tcr	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11876
# text = IL-2 promoter activation in Jurkat T cells stimulated with superantigen presented by Raji B cells requires CD28 activation.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	superantigen	superantigen	NOUN	NNS	Number=Plur	_	_	_	_
13	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11877
# text = The addition of rCTLA4
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	rCTLA4	rCTLA4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No

# sent_id = 11878
# text = Ig, which blocks CD28 binding to its ligand, to the cultures decreased IL-2 promoter activation by >80%. Interestingly, CTLA4Ig did not significantly inhibit the activation of either NF of activated T cells (NFAT) or AP-1 reporters.
1	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	>	>	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	80%	80%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_
24	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	CTLA4	CTLA4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	significantly	significantly	ADV	RB	_	_	_	_	_
31	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	either	either	CCONJ	CC	_	_	_	_	_
36	NF	Nf	ADP	IN	_	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	T	t	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	reporters	reporter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11879
# text = Therefore, activation of NFAT and AP-1 is insufficient for IL-2 promoter activation.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	AP	ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11880
# text = In contrast, an RE/AP reporter was blocked by CTLA4Ig by >90%.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	RE	re	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	CTLA4	CTLA4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	>90%	>90%	X	XX	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11881
# text = Thus, the requirement for CD28 in IL-2 promoter activation appears to be due to RE/AP and not the NFAT or AP-1 sites.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	RE	re	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11882
# text = In addition, these data suggest that transcriptional activation of RE/AP is not mediated by NFAT, because activation of a NFAT reporter is not affected by the addition of CTLA4Ig.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	RE	re	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	because	because	SCONJ	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	NFAT	NFAT	ADJ	JJ	Degree=Pos	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	CTLA4	CTLA4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11883
# text = Document 0030012745 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012745	0030012745	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11884
# text = Anoxia/reoxygenation-induced tolerance with respect to polymorphonuclear leukocyte adhesion to cultured endothelial cells.
1	Anoxia/	Anoxia/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	reoxygenation	reoxygenation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	polymorphonuclear	polymorphonuclear	VERB	VB	VerbForm=Inf	_	_	_	_
10	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	cultured	cultured	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11885
# text = A nuclear factor-kappaB-mediated phenomenon.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11886
# text = Exposing human umbilical vein endothelial cells (HUVECs) to anoxia/reoxygenation (A/R) results in an increase in polymorphonuclear leukocyte (PMN) adhesion to HUVECs.
1	Exposing	Expose	VERB	VBG	VerbForm=Ger	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
4	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	anoxia	anoxia	ADP	IN	_	_	_	_	SpaceAfter=No
12	/reoxygenation	/reoxygenation	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	A/	Aith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	R	R	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	results	result	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PMN	PMN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11887
# text = This A/R-induced hyperadhesion is completely prevented by a previous (24 hours earlier) exposure of HUVECs to A/R.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	A/R-induced	A/R-induced	ADJ	JJ	Degree=Pos	_	_	_	_
3	hyperadhesion	hyperadhesion	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	completely	completely	ADV	RB	_	_	_	_	_
6	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	24	24	NUM	CD	NumType=Card	_	_	_	_
12	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
13	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	A/R.	A/R.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 11888
# text = This phenomenon has been termed "A/R tolerance."
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	termed	term	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
7	A/R	A/r	ADJ	JJ	Degree=Pos	_	_	_	_
8	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpaceAfter=No
10	"	"	PUNCT	''	_	_	_	_	_

# sent_id = 11889
# text = Exposing HUVECs to A/R induces an increase in nuclear factor kappaB (NF-kappaB) in HUVEC nuclei within 4 hours.
1	Exposing	Expose	VERB	VBG	VerbForm=Ger	_	_	_	_
2	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	A/R	A/R	PROPN	NNP	Number=Sing	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	HUVEC	Huvec	PROPN	NNP	Number=Sing	_	_	_	_
19	nuclei	nuclei	PROPN	NNP	Number=Sing	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11890
# text = Interfering with either NF-kappaB activation (proteasome inhibitor) or translocation (double-stranded oligonucleotides containing NF-kappaB binding sequence) prevents the development of A/R tolerance (ie, the increase in A/R-induced PMN adhesion to HUVECs is the same after the first and second A/R challenges).
1	Interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	either	either	CCONJ	CC	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stranded	stranded	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	oligonucleotides	oligonucleotides	NOUN	NNS	Number=Plur	_	_	_	_
19	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	development	development	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
31	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	A/R-	A/R-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	PMN	Pmn	ADP	IN	_	_	_	_	_
41	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
47	after	after	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
52	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
53	challenges	challenge	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11891
# text = NO production by HUVECs is increased after the second A/R challenge, but not after the first A/R challenge.
1	NO	no	DET	DT	_	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	HUVECs	HUVEC	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	after	after	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
11	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
19	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11892
# text = Inhibition of NO synthase (NOS) during the second A/R challenge prevents the development of A/R tolerance with respect to PMN adhesion.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NO	no	DET	DT	_	_	_	_	_
4	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NOS	NOS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
12	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	_
13	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	A/R	A/r	ADJ	JJ	Degree=Pos	_	_	_	_
18	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	PMN	Pmn	VERB	VB	VerbForm=Inf	_	_	_	_
23	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11893
# text = However, while HUVECs contained endothelial NOS protein, no inducible NOS was detected in either tolerant or nontolerant cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	HUVECs	Huvecs	NOUN	NNS	Number=Plur	_	_	_	_
5	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	NOS	no	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	no	no	DET	DT	_	_	_	_	_
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
12	NOS	Nos	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	nontolerant	nontolerant	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11894
# text = Further studies indicated that inhibition of GTP-cyclohydrolase I (an enzyme involved in de novo synthesis of an important cofactor for NOS activity, tetrahydrobiopterin) prevented the generation of NO in A/R-tolerant cells.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cyclohydrolase	cyclohydrolase	NOUN	NN	Number=Sing	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
14	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	de	de	PROPN	NNP	Number=Sing	_	_	_	_
17	novo	novo	ADV	RB	_	_	_	_	_
18	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
22	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	NOS	NOS	PROPN	NNP	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	tetrahydrobiopterin	tetrahydrobiopterin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NO	no	DET	DT	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	A/R-	A/R-	X	AFX	_	_	_	_	SpaceAfter=No
36	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11895
# text = Extracellular generation of NO (NO donor) did not effect the hyperadhesion response induced by the initial A/R challenge.
1	Extracellular	Extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NO	no	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NO	no	DET	DT	_	_	_	_	_
7	donor	donor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	effect	effect	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	hyperadhesion	hyperadhesion	NOUN	NN	Number=Sing	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
19	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
20	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11896
# text = A/R also induced an oxidant stress in naive HUVECs, but not in A/R-tolerant HUVECs.
1	A/R	A/R	ADV	RB	_	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
6	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
9	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	A/R-	A/R-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	tolerant	tolerant	ADJ	JJ	Degree=Pos	_	_	_	_
16	HUVECs	HUVEC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11897
# text = Inhibition of NOS during the second A/R insult results in the generation of an oxidant stress similar to that observed after the first A/R challenge.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NOS	no	PROPN	NNP	Number=Sing	_	_	_	_
4	during	during	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
8	insult	insult	NOUN	NN	Number=Sing	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
16	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
24	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
25	challenge	challenge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11898
# text = Taken together, the findings of the present study are consistent with a role for NF-kappaB in the development of A/R tolerance (with respect to PMN adhesion), perhaps by transcriptional regulation of GTP-cyclohydrolase.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
9	study	study	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	development	development	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	A/R	A/r	PROPN	NNP	Number=Sing	_	_	_	_
24	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	with	with	ADP	IN	_	_	_	_	_
27	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	PMN	Pmn	X	GW	_	_	_	_	_
30	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	perhaps	perhaps	ADV	RB	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	cyclohydrolase	cyclohydrolase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11899
# text = The increased NO production during the second A/R insult reduces PMN adhesion most likely by reducing the intracellular oxidant stress induced by A/R.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	NO	no	DET	DT	_	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
8	A/R	A/r	NOUN	NN	Number=Sing	_	_	_	_
9	insult	insult	NOUN	NN	Number=Sing	_	_	_	_
10	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	PMN	PMN	X	GW	_	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	most	most	ADV	RBS	_	_	_	_	_
14	likely	likely	ADV	RB	_	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
20	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	A/	A/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
24	R.	R.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11900
# text = Document 0030012746 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012746	0030012746	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11901
# text = Hypoxic induction of interleukin-8 gene expression in human endothelial cells.
1	Hypoxic	Hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	8	8	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11902
# text = Because leukocyte-mediated tissue damage is an important component of the pathologic picture in ischemia/reperfusion, we have sought mechanisms by which PMNs are directed into hypoxic tissue.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
6	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	pathologic	pathologic	ADJ	JJ	Degree=Pos	_	_	_	_
14	picture	picture	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	ischemia	ischemion	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	reperfusion	reperfusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	sought	seek	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	PMNs	PMNs	NOUN	NNS	Number=Plur	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	hypoxic	hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
31	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11903
# text = Incubation of human endothelial cells (ECs) in hypoxia, PO2 approximately 14-18 Torr, led to time-dependent release of IL-8 antigen into the conditioned medium; this was accompanied by increased chemotactic activity for PMNs, blocked by antibody to IL-8.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ECs	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	PO2	PO2	NUM	CD	NumType=Card	_	_	_	_
13	approximately	approximately	ADV	RB	_	_	_	_	_
14	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	18	18	NUM	CD	NumType=Card	_	_	_	_
17	Torr	Torr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	8	8	NUM	CD	NumType=Card	_	_	_	_
29	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
30	into	into	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	conditioned	condition	ADJ	JJ	Degree=Pos	_	_	_	_
33	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	;	;	PUNCT	,	_	_	_	_	_
35	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	PMNs	PMN	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11904
# text = Production of IL-8 by hypoxic ECs occurred concomitantly with both increased levels of IL-8 mRNA, based on polymerase chain reaction analysis, and increased IL-8 transcription, based on nuclear run-on assays.
1	Production	Production	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	8	8	NUM	CD	NumType=Card	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	hypoxic	hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
8	ECs	Ecs	PROPN	NNPS	Number=Plur	_	_	_	_
9	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	concomitantly	concomitantly	ADV	RB	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	8	8	PROPN	NNP	Number=Sing	_	_	_	_
19	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
26	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	8	8	NUM	CD	NumType=Card	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	on	on	ADP	IN	_	_	_	_	_
37	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	on	on	ADP	IN	_	_	_	_	_
41	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11905
# text = Northern analysis of mRNA from hypoxic ECs also demonstrated increased levels of mRNA for macrophage chemotactic protein-1, another member of the chemokine superfamily of proinflammatory cytokines.
1	Northern	northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	hypoxic	hypoxic	PROPN	NNP	Number=Sing	_	_	_	_
7	ECs	Ecs	PROPN	NNP	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	_
16	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	another	another	DET	DT	_	_	_	_	_
22	member	member	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
26	superfamily	superfamily	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
29	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11906
# text = IL-8 gene induction was associated with the presence of increased binding activity in nuclear extracts from hypoxic ECs for the NF-kB site.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	8	8	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	hypoxic	hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
20	ECs	EC	NOUN	NNS	Number=Plur	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11907
# text = Studies with human umbilical vein segments exposed to hypoxia also demonstrated increased elaboration of IL-8 antigen compared with normoxic controls.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
5	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
6	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
7	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	hypoxia	hypoxia	PROPN	NNP	Number=Sing	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	elaboration	elaboration	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	8	8	NUM	CD	NumType=Card	_	_	_	_
18	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
19	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	normoxic	normoxic	ADJ	JJ	Degree=Pos	_	_	_	_
22	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11908
# text = In mice exposed to hypoxia (PO2 approximately 30-40 Torr), there was increased pulmonary leukostasis, as evidenced by increased myeloperoxidase activity in tissue homogenates.
1	In	in	ADP	IN	_	_	_	_	_
2	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
3	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PO2	PO2	NUM	CD	NumType=Card	_	_	_	_
8	approximately	approximately	ADV	RB	_	_	_	_	_
9	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	40	40	NUM	CD	NumType=Card	_	_	_	_
12	Torr	Torr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	there	there	PRON	EX	_	_	_	_	_
16	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	pulmonary	pulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukostasis	leukostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	myeloperoxidase	myeloperoxidase	NOUN	NN	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
29	homogenates	homogenate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11909
# text = In parallel, increased levels of transcripts for IP-10, a murine homologue in the chemokine family related to IL-8, were observed in hypoxic lung tissue.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	IP	ip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
15	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	hypoxic	hypoxic	ADJ	JJ	Degree=Pos	_	_	_	_
30	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
31	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11910
# text = Taken together, these data suggest that hypoxia constitutes a stimulus for leukocyte chemotaxis and tissue leukostasis.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	hypoxia	hypoxia	NOUN	NN	Number=Sing	_	_	_	_
9	constitutes	constitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
14	chemotaxis	chemotaxis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
17	leukostasis	leukostasis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11911
# text = Document 0030012747 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012747	0030012747	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11912
# text = Coactivation by OCA-B: definition of critical regions and synergism with general cofactors.
1	Coactivation	Coactivation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	OCA	OCA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	B	B	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	definition	definition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
15	cofactors	cofactor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11913
# text = Molecular dissection of the B-cell-specific transcription coactivator OCA-B has revealed distinct regions important, respectively, for recruitment to immunoglobulin promoters through interaction with octamer-bound Oct-1 and for subsequent coactivator function.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
11	OCA	OCA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	B	B	PROPN	NNP	Number=Sing	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	immunoglobulin	immunoglobulin	VERB	VB	VerbForm=Inf	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
33	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
39	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
40	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11914
# text = Further analysis of general coactivator requirements showed that selective removal of PC4 from the essential USA fraction severely impairs Oct-1 and OCA-B function in a cell-free system reconstituted with partially purified factors.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
5	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
6	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
7	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
10	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	PC4	PC4	NUM	CD	NumType=Card	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
16	USA	USA	PROPN	NNP	Number=Sing	_	_	_	_
17	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
18	severely	severely	ADV	RB	_	_	_	_	_
19	impairs	impairs	ADJ	JJ	Degree=Pos	_	_	_	_
20	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-1	-1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	OCA	OCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
32	system	system	NOUN	NN	Number=Sing	_	_	_	_
33	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	partially	partially	ADV	RB	_	_	_	_	_
36	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11915
# text = Full activity can be restored by the combined action of recombinant PC4 and the PC4-depleted USA fraction, thus suggesting a joint requirement for PC4 and another, USA-derived component(s) for optimal function of Oct-1/OCA-B in the reconstituted system.
1	Full	full	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	restored	restore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
12	PC4	Pc4	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	PC4	Pc4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	USA	USA	PROPN	NNP	Number=Sing	_	_	_	_
19	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	thus	thus	ADV	RB	_	_	_	_	_
22	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	joint	joint	ADJ	JJ	Degree=Pos	_	_	_	_
25	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	PC4	Pc4	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	another	another	DET	DT	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	USA	USA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	s	s	X	AFX	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
40	function	function	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	Oct-1/OCA	Oct-1/OCA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	B	B	PROPN	NNP	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11916
# text = Indeed, USA-derived PC2 was found to act synergistically with PC4 in reproducing the function of intact USA in the assay system.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	USA	USA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	PC2	Pc2	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
11	synergistically	synergistically	ADV	RB	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	PC4	Pc4	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	reproducing	reproduce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
20	USA	USA	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11917
# text = Consistent with the requirement for PC4 in the reconstituted system, OCA-B was found to interact directly with PC4.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	PC4	PC4	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	OCA	OCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
19	directly	directly	ADV	RB	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	PC4	PC4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11918
# text = Surprisingly, however, removal of PC4 from the unfractionated nuclear extract has no detrimental effect on OCA-B/Oct-1-dependent transcription.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PC4	PC4	NUM	CD	NumType=Card	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	unfractionated	unfractionated	ADJ	JJ	Degree=Pos	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	detrimental	detrimental	ADJ	JJ	Degree=Pos	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	OCA	OCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Oct	oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11919
# text = These results lead to a general model for the synergistic function of activation domains in Oct-1 and OCA-B (mediated by the combined action of the multiple USA components) and, further, suggest a functional redundancy in general coactivators.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
7	model	model	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	OCA	OCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	action	action	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
32	USA	USA	PROPN	NNP	Number=Sing	_	_	_	_
33	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	further	further	ADV	RB	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
42	redundancy	redundancy	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
45	coactivators	coactivator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11920
# text = Document 0030012752 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012752	0030012752	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11921
# text = Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11922
# text = The present work has examined the effects of okadaic acid, an inhibitor of type 1 and 2A protein phosphatases, on the regulation of c-jun expression during monocytic differentiation of U-937 leukemia cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	during	during	ADP	IN	_	_	_	_	_
31	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	937	937	NUM	CD	NumType=Card	_	_	_	_
37	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11923
# text = The results demonstrate that okadaic acid treatment is associated with induction of a differentiated monocyte phenotype characterized by: (a) growth arrest; (b) increases in Mac-1 cell surface antigen expression; (c) down-regulation of c-myc transcripts; and (d) induction of tumor necrosis factor gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
6	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
16	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
17	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	a	a	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
24	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	;	;	PUNCT	,	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
36	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	;	;	PUNCT	,	_	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
47	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
48	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	;	;	PUNCT	,	_	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	d	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
57	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
58	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
59	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
60	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11924
# text = This induction of monocytic differentiation was associated with transient increases in c-jun mRNA levels, which were maximal at 6 h.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
10	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11925
# text = Similar effects were obtained for the c-fos gene.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11926
# text = Run-on analysis demonstrated detectable levels of c-jun transcription in U-937 cells and that this rate is increased approximately 40-fold following okadaic acid exposure.
1	Run	run	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	on	on	ADP	IN	_	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	937	937	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	approximately	approximately	ADV	RB	_	_	_	_	_
24	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
29	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
30	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11927
# text = c-jun mRNA levels were superinduced in cells treated with both okadaic acid and cycloheximide, whereas inhibition of protein synthesis had little, if any, effect on okadaic acid-induced c-jun transcription.
1	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
3	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	superinduced	superinduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
22	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	little	little	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	if	if	SCONJ	IN	_	_	_	_	_
26	any	any	DET	DT	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
31	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11928
# text = The half-life of c-jun mRNA was similar (45-50 min) in both untreated and okadaic acid-induced cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	life	life	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	45	45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	50	50	NUM	CD	NumType=Card	_	_	_	_
15	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
22	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11929
# text = In contrast, treatment with both okadaic acid and cycloheximide was associated with stabilization (t 1/2 = 90 min) of c-jun transcripts.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
8	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	stabilization	stabilization	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	t	t	NUM	CD	NumType=Card	_	_	_	_
17	1/2	1/2	NUM	CD	NumType=Card	_	_	_	_
18	=	=	SYM	SYM	_	_	_	_	_
19	90	90	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
25	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11930
# text = Taken together, these findings indicate that the induction of c-jun transcription by okadaic acid is controlled primarily by a transcriptional mechanism.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	primarily	primarily	ADV	RB	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11931
# text = Since previous studies have demonstrated that the c-jun gene is autoinduced by Jun/AP-1, we also studied transcription of c-jun promoter (positions -132/+170)-reporter gene constructs with and without a mutated AP-1 element.
1	Since	since	ADP	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	autoinduced	autoinduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Jun/	Jun/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	132/+170	132/+170	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	without	without	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11932
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11933
# text = Document 0030012757 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012757	0030012757	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11934
# text = Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes.
1	Occurrence	occurrence	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
17	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	T	t	NUM	CD	NumType=Card	_	_	_	_
19	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11935
# text = In the immune system the first activation of a naive T cell by antigen is a key step in the shaping of the peripheral T cell specificity repertoire and maintenance of self-tolerance.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
18	step	step	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	shaping	shaping	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
28	repertoire	repertoire	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11936
# text = In the present study, analysis of the interleukin-2 (IL-2) gene activation shows that naive human helper T cells (cord blood CD4+ T cells, adult CD4+CD45RO-
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	shows	show	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	naive	naive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
28	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
29	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	+	+	SYM	SYM	_	_	_	_	_
31	T	t	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
35	CD4+	Cd4+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	CD45RO	Cd45ro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	_

# sent_id = 11937
# text = T cells) regulate IL-2 transcription by a mechanism involving both a silencer and an activator acting on the purine-rich IL-2 promoter elements (NF-AT binding sites).
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
12	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
19	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	purine	purine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	AT	AT	SCONJ	IN	_	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11938
# text = By contrast, memory cells, either in vitro activated helper T cells reverting to a resting state, or CD4+ T (memory) clones, or CD4+CD45RO+
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	either	either	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	helper	helper	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	reverting	revert	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	resting	resting	VERB	VBG	VerbForm=Ger	_	_	_	_
18	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	T	t	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	memory	memory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	CD4+	CD4+	SYM	SYM	_	_	_	_	SpaceAfter=No
31	CD45RO	CD45RO	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	+	+	SYM	SYM	_	_	_	_	_

# sent_id = 11939
# text = T cells isolated ex vivo, no longer have a silencer.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	ex	ex	NOUN	NN	Number=Sing	_	_	_	_
5	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	no	no	ADV	RB	_	_	_	_	_
8	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
9	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11940
# text = Their IL-2 transcription seems to be controlled solely by the transition from inactive to active functional state of a positive transcription factor binding to these promoter elements as well as its cytoplasmic or nuclear location: in resting memory T cells the activator is located in the cytoplasm and is inactive, whereas in stimulated cells it is functional in promoting transcription and now resides in the nucleus.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	solely	solely	ADV	RB	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
18	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
19	state	state	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
30	as	as	ADV	RB	_	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	location	location	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	:	:	PUNCT	:	_	_	_	_	_
39	in	in	SCONJ	IN	_	_	_	_	_
40	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
41	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
46	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
47	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	whereas	whereas	SCONJ	IN	_	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
59	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
60	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
61	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
62	in	in	SCONJ	IN	_	_	_	_	_
63	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
64	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	now	now	ADV	RB	_	_	_	_	_
67	resides	reside	NOUN	NNS	Number=Plur	_	_	_	_
68	in	in	ADP	IN	_	_	_	_	_
69	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
70	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11941
# text = Thus, the regulation of the gene coding for the main T cell growth factor changes irreversibly after the first encounter of T cells with antigen.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	coding	coding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
17	irreversibly	irreversibly	ADV	RB	_	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
21	encounter	encounter	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11942
# text = It is most likely that the presence of a silencer contributes to the more stringent activation requirements of naive CD4+ T cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	most	most	ADV	RBS	_	_	_	_	_
4	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
11	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	more	more	ADV	RBR	_	_	_	_	_
15	stringent	stringent	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
20	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	T	t	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11943
# text = Document 0030012759 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012759	0030012759	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11944
# text = Permanent occupancy of the human immunodeficiency virus type 1 enhancer by NF-kappa B is needed for persistent viral replication in monocytes.
1	Permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
2	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
20	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11945
# text = This work aimed to ascertain the role of kappaB-responsive elements of the human immunodeficiency virus type 1 (HIV-1) enhancer not only in early initiation but also in long-term maintenance of proviral transcription in cells of the monocytic lineage.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	aimed	aim	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	ascertain	ascertain	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	term	term	NOUN	NN	Number=Sing	_	_	_	_
37	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
46	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11946
# text = For this purpose, we used three main approaches.
1	For	for	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
9	approaches	approach	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11947
# text = The first was to abruptly terminate tumor necrosis factor-induced NF-kappaB binding to the enhancer sequences in U1 monocytic cells, using a short pulse of exogenous tumor necrosis factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	abruptly	abruptly	ADV	RB	_	_	_	_	_
6	terminate	terminate	VERB	VB	VerbForm=Inf	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	U1	U1	NUM	CD	NumType=Card	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
27	pulse	pulse	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
30	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
31	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11948
# text = This resulted in concomitant decrease in nuclear NF-kappaB DNA-binding activity and endogenous long terminal repeat transcriptional activity.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
5	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	repeat	repeat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11949
# text = The second was to suppress the permanent NF-kappaB translocation induced by HIV-1 replication itself in chronically infected U937 cells, using a specific proteasome inhibitor (Z-LLL-H).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
18	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	in	in	ADV	RB	_	_	_	_	_
20	chronically	chronically	ADV	RB	_	_	_	_	_
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	U937	U937	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	_
29	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Z	Z	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	LLL	LLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	H	H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11950
# text = As early as 2 h after addition of the inhibitor to the culture medium, there was an inhibition of both constitutive activation of NF-kappaB and HIV-1 genome expression.
1	As	as	ADV	RB	_	_	_	_	_
2	early	early	ADV	RB	Degree=Pos	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	h	h	NOUN	NN	Number=Sing	_	_	_	_
6	after	after	ADP	IN	_	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
14	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	there	there	PRON	EX	_	_	_	_	_
17	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11951
# text = The third approach was to monitor the replication competence in U937 cells of an infectious HIV-1 provirus carrying point mutations in the kappaB-responsive elements of both long terminal repeats.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	competence	competence	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	U937	U937	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
20	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
21	point	point	NOUN	NN	Number=Sing	_	_	_	_
22	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
32	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
33	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11952
# text = Compared with its wild-type counterpart, this mutated provirus showed a profoundly decreased, Z-LLL-H-insensitive transcriptional and replicative activity in U937 monocytes.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	counterpart	counterpart	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	mutated	mutated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	provirus	provirus	CCONJ	CC	_	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	profoundly	profoundly	ADV	RB	_	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Z	Z	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	LLL	LLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	H	H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	U937	U937	NUM	CD	NumType=Card	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11953
# text = Together, our results indicate that occupancy of the viral enhancer by NF-kappaB (p50/p65) heterodimers is required for ongoing transcription of integrated HIV provirus in monocytes, even in cells chronically infected and permanently producing functional HIV Tat protein.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
19	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	heterodimers	heterodimers	NOUN	NNS	Number=Plur	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
30	provirus	provirus	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	even	even	ADV	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	chronically	chronically	ADV	RB	_	_	_	_	_
38	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	permanently	permanently	ADV	RB	_	_	_	_	_
41	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
42	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
43	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
44	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
45	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11954
# text = Thus, the ability of HIV-1 replication to activate NF-kappaB is crucial to the intense self-perpetuated viral transcription observed in cells of the monocytic lineage.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	intense	intense	ADJ	JJ	Degree=Pos	_	_	_	_
20	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	perpetuated	perpetuate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11955
# text = Document 0030012763 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012763	0030012763	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11956
# text = Efficient transcription and replication of simian immunodeficiency virus in the absence of NF-kappaB and Sp1 binding elements.
1	Efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11957
# text = Ten mutants of the simian immunodeficiency virus (SIV) SIVmac239 bearing deletions (delta) or substitutions (subst) in the NF-kappaB and/or Sp1 binding elements were created, and the replicative capacities of the mutants were analyzed.
1	Ten	ten	NUM	CD	NumType=Card	_	_	_	_
2	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	SIV	SIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	SIVmac239	SIVmac239	NUM	CD	NumType=Card	_	_	_	_
12	bearing	bearing	NOUN	NN	Number=Sing	_	_	_	_
13	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	delta	delta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	subst	subst	ADJ	JJS	Degree=Sup	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	or	or	CCONJ	CC	_	_	_	_	_
30	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	created	create	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
39	capacities	capacitie	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11958
# text = All mutants, including one extensively mutagenized strain entirely missing the NF-kappaB and four Spl binding elements, replicated with wild-type kinetics and to a wild-type level in peripheral blood mononuclear cell cultures in 50 to 100% of the experiments.
1	All	all	DET	DT	_	_	_	_	_
2	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	extensively	extensively	ADV	RB	_	_	_	_	_
7	mutagenized	mutagenize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
9	entirely	entirely	ADV	RB	_	_	_	_	_
10	missing	miss	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	four	four	NUM	CD	NumType=Card	_	_	_	_
17	Spl	Spl	NOUN	NN	Number=Sing	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	replicated	replicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	level	level	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
36	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
37	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	50	50	NUM	CD	NumType=Card	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	%	%	SYM	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11959
# text = One group of mutants replicated very similarly to SIVmac239 in kinetics and yield in CEMxl74 cells (2xNFKappaB >
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	group	group	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
5	replicated	replicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	very	very	ADV	RB	_	_	_	_	_
7	similarly	similarly	ADV	RB	_	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	SIVmac239	SIVmac239	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	yield	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CEMxl74	CEMxl74	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	2xNFKappaB	2xNFKappaB	NOUN	NN	Number=Sing	_	_	_	_
19	>	>	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 11960
# text = or = SlVmac239 approximately deltaNFkappaB approximately deltaSpl234 approximately substNFkappaB approximately substSpl2 approximately substSp23), while a second group replicated with delayed or slightly delayed kinetics in CEMxl74 cells (SIVmac239 > substSp34 > deltaNFkappaBdeltaSpl234 approximately deltaNFkappaBdeltaSp1 > substSpl234).
1	or	or	CCONJ	CC	_	_	_	_	_
2	=	=	SYM	SYM	_	_	_	_	_
3	SlVmac239	SlVmac239	NUM	CD	NumType=Card	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	deltaNFkappaB	deltaNFkappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	approximately	approximately	ADV	RB	_	_	_	_	_
7	deltaSpl234	deltaSpl234	NUM	CD	NumType=Card	_	_	_	_
8	approximately	approximately	ADV	RB	_	_	_	_	_
9	substNFkappaB	substNFkappaB	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	approximately	approximately	ADV	RB	_	_	_	_	_
11	substSpl2	substSpl2	NUM	CD	NumType=Card	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	substSp23	substSp23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
19	group	group	NOUN	NN	Number=Sing	_	_	_	_
20	replicated	replicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	slightly	slightly	ADV	RB	_	_	_	_	_
25	delayed	delayed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	CEMxl74	CEMxl74	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	SIVmac239	SIVmac239	NUM	CD	NumType=Card	_	_	_	_
32	>	>	SYM	NFP	_	_	_	_	_
33	substSp34	substSp34	NUM	CD	NumType=Card	_	_	_	_
34	>	>	SYM	NFP	_	_	_	_	_
35	deltaNFkappaBdeltaSpl234	deltaNFkappaBdeltaSpl234	NUM	CD	NumType=Card	_	_	_	_
36	approximately	approximately	ADV	RB	_	_	_	_	_
37	deltaNFkappaBdeltaSp1	deltaNFkappaBdeltaSp1	NUM	CD	NumType=Card	_	_	_	_
38	>	>	PUNCT	-RRB-	_	_	_	_	_
39	substSpl234	substSpl234	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11961
# text = Reversions or additional mutations were not detected in the U3 and R regions of proviral DNA from CEMxl74 cells infected with the SIVmac239 mutants.
1	Reversions	Reversion	NOUN	NNS	Number=Plur	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	U3	U3	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	R	be	ADJ	JJR	Degree=Cmp	_	_	_	_
13	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	CEMxl74	CEMxl74	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	SIVmac239	Sivmac239	NOUN	NN	Number=Sing	_	_	_	_
24	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11962
# text = Similar results were obtained when mutants of SIVmacMER (a macrophage-competent derivative of SIVmac239) were tested in peripheral blood mononuclear cell and CEMx174 cultures.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	SIVmacMER	SIVmacMER	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	competent	competent	ADJ	JJ	Degree=Pos	_	_	_	_
14	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	SIVmac239	SIVmac239	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	CEMx	CEMx	SYM	SYM	_	_	_	_	SpaceAfter=No
27	174	174	NUM	CD	NumType=Card	_	_	_	_
28	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11963
# text = However, the growth of most mutated viruses was suppressed in primary rhesus monkey alveolar macrophages (SIVmacMER approximately 2xNFkappaB approximately substNFkappaB > deltaNFkappaB > deltaNFkappaBdeltaSpl234 approximately deltaNFkappaBdeltaSpl > deltaSpl234 approximately substSpl2 > substSp23 approximately substSp34 approximately substSpl234 > or = SIVmac239).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
7	mutated	mutate	ADJ	JJ	Degree=Pos	_	_	_	_
8	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
13	rhesus	rhesus	NOUN	NN	Number=Sing	_	_	_	_
14	monkey	monkey	NOUN	NN	Number=Sing	_	_	_	_
15	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	SIVmacMER	Sivmacmer	ADV	RB	_	_	_	_	_
19	approximately	approximately	ADV	RB	_	_	_	_	_
20	2xNFkappaB	2xNFkappaB	ADV	RB	_	_	_	_	_
21	approximately	approximately	ADV	RB	_	_	_	_	_
22	substNFkappaB	substNFkappaB	ADV	RB	_	_	_	_	_
23	>	>	PUNCT	,	_	_	_	_	_
24	deltaNFkappaB	deltaNFkappaB	NOUN	NN	Number=Sing	_	_	_	_
25	>	>	PUNCT	,	_	_	_	_	_
26	deltaNFkappaBdeltaSpl234	deltaNFkappaBdeltaSpl234	NUM	CD	NumType=Card	_	_	_	_
27	approximately	approximately	ADV	RB	_	_	_	_	_
28	deltaNFkappaBdeltaSpl	deltaNFkappaBdeltaSpl	NOUN	NN	Number=Sing	_	_	_	_
29	>	>	PUNCT	-RRB-	_	_	_	_	_
30	deltaSpl234	deltaSpl234	NUM	CD	NumType=Card	_	_	_	_
31	approximately	approximately	ADV	RB	_	_	_	_	_
32	substSpl2	substSpl2	NUM	CD	NumType=Card	_	_	_	_
33	>	>	SYM	NFP	_	_	_	_	_
34	substSp23	substSp23	NUM	CD	NumType=Card	_	_	_	_
35	approximately	approximately	ADV	RB	_	_	_	_	_
36	substSp	substsp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	34	34	NUM	CD	NumType=Card	_	_	_	_
38	approximately	approximately	ADV	RB	_	_	_	_	_
39	substSpl234	substSpl234	NUM	CD	NumType=Card	_	_	_	_
40	>	>	PUNCT	,	_	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	=	=	SYM	SYM	_	_	_	_	_
43	SIVmac239	SIVmac239	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11964
# text = Thus, changes in the Sp1 binding sites had the most dramatic effects on SIVmac replication in primary macrophage cultures.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Sp1	Sp1	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	most	most	ADV	RBS	_	_	_	_	_
12	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
13	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	SIVmac	SIVmac	PROPN	NNP	Number=Sing	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11965
# text = Analysis of long terminal repeat-driven secreted alkaline phosphatase activity in transient assays showed that, unlike human immunodeficiency virus type 1, the SIV long terminal repeat possesses an enhancer region just upstream of the NF-kappaB element which maintains significant levels of basal transcription in the absence of NF-kappaB and Sp1 sites.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
4	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
5	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
10	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
14	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	unlike	unlike	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	SIV	SIV	PROPN	NNP	Number=Sing	_	_	_	_
27	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
28	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
29	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	possesses	possess	NOUN	NNS	Number=Plur	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	just	just	ADV	RB	_	_	_	_	_
35	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
41	element	element	NOUN	NN	Number=Sing	_	_	_	_
42	which	which	PRON	WDT	PronType=Rel	_	_	_	_
43	maintains	maintain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
45	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
48	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
58	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11966
# text = This region is responsive to transactivation by Tat.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	transactivation	transactivation	VERB	VB	VerbForm=Inf	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11967
# text = In addition, the SIV TATA box was shown to be stronger than that of human immunodeficiency virus type 1.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	SIV	SIV	PROPN	NNP	Number=Sing	_	_	_	_
6	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	stronger	stronger	ADJ	JJR	Degree=Cmp	_	_	_	_
13	than	than	ADP	IN	_	_	_	_	_
14	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11968
# text = Therefore, the surprisingly high replicative capacity of NF-kappaB and Sp1 binding site mutants of SIVmac is due to unique features or the enhancer/promoter region.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	surprisingly	surprisingly	ADV	RB	_	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	SIVmac	SIVmac	PROPN	NNP	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	due	due	ADP	IN	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
23	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11969
# text = Document 0030012767 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012767	0030012767	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11970
# text = Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor.kappa	factor.kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	C	C	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11971
# text = Autocrine role of tumor necrosis factor alpha.
1	Autocrine	Autocrine	PROPN	NNP	Number=Sing	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11972
# text = The regulation of interleukin-2 receptor alpha chain (IL-2R alpha) expression and nuclear factor (NF) activation by protein kinase C (PKC) in resting T cells, has been studied.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	C	C	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	in	in	SCONJ	IN	_	_	_	_	_
32	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11973
# text = Treatment of human resting T cells with phorbol esters strongly induced the expression of IL-2R alpha and the activation of NF.kappa B.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
10	strongly	strongly	ADV	RB	_	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11974
# text = This activation was due to the translocation of p65 and c-Rel NF.kappa B proteins from cytoplasmic stores to the nucleus, where they bound the kappa B sequence of the IL-2R alpha promoter either as p50.p65 or as p50.c-Rel heterodimers.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	due	due	ADP	IN	_	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	B	ADJ	JJ	Degree=Pos	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
19	stores	store	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	where	where	ADV	WRB	PronType=Rel	_	_	_	_
25	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
26	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	either	either	CCONJ	CC	_	_	_	_	_
39	as	as	ADP	IN	_	_	_	_	_
40	p50.p65	p50.p65	NUM	CD	NumType=Card	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	p50.c	p50.c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
46	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11975
# text = Interestingly, all of those events were largely indirect and mediated by endogenously secreted tumor necrosis factor alpha (TNF alpha), as they were strongly inhibited by a neutralizing anti-TNF alpha monoclonal antibody.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	events	event	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	largely	largely	ADV	RB	_	_	_	_	_
9	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	endogenously	endogenously	ADV	RB	_	_	_	_	_
14	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
16	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	strongly	strongly	ADV	RB	_	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	neutralizing	neutralizing	ADJ	JJ	Degree=Pos	_	_	_	_
32	anti-TNF	anti-tnf	NOUN	NN	Number=Sing	_	_	_	_
33	alpha	alpha	ADP	IN	_	_	_	_	_
34	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
35	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11976
# text = Furthermore, cyclosporin A, which blocked TNF alpha production induced by PKC, strongly inhibited IL-2R alpha and NF.kappa B activation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cyclosporin	cyclosporin	ADP	IN	_	_	_	_	_
4	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	ADP	IN	_	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	strongly	strongly	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	B	PROPN	NNP	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11977
# text = The addition of either TNF alpha or IL-2 partially recovered cyclosporin A-induced IL-2R alpha inhibition, but only TNF alpha completely recovered NF.kappa B activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	partially	partially	ADV	RB	_	_	_	_	_
12	recovered	recover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
27	completely	completely	ADV	RB	_	_	_	_	_
28	recovered	recover	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11978
# text = Those results indicate that, in resting T cells, PKC activation has only a triggering role, whereas the endogenously secreted TNF alpha plays an essential role in the quantitative control of the expression of IL-2R alpha chain or NF.kappa B activation.
1	Those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	SCONJ	IN	_	_	_	_	_
7	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	endogenously	endogenously	ADV	RB	_	_	_	_	_
22	secreted	secret	ADJ	JJ	Degree=Pos	_	_	_	_
23	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
41	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	NF.kappa	NF.kappa	PROPN	NNP	Number=Sing	_	_	_	_
44	B	b	PROPN	NNP	Number=Sing	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11979
# text = Document 0030012769 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012769	0030012769	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11980
# text = Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.
1	Octamer	Octamer	PROPN	NNP	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
11	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	spi	spi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11981
# text = PU.1 (spi-1), a member of the Ets transcription factor family, is predominantly expressed in myeloid and B cells, activates many B cell and myeloid genes, and is critical for development of both of these lineages.
1	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	spi	spi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	member	member	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	predominantly	predominantly	ADV	RB	_	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	development	development	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	both	both	DET	DT	_	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11982
# text = Our previous studies (Chen, H.M., Ray-Gallet, D., Zhang, P., Hetherington, C.J., Gonzalez, D.A., Zhang, D.-E., Moreau-Gachelin, F., and Tenen, D.G.(1995) Oncogene 11, 1549-1560) demonstrate that the PU.1 promoter directs cell type-specific reporter gene expression in myeloid cell lines, and that PU.1 activates its own promoter in an autoregulatory loop.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	Chen	Chen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	H.M.	H.M.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Ray	Ray	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Gallet	Gallet	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	D.	D.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Zhang	Zhang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	P.	P.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Hetherington	Hetherington	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	C.J.	C.J.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Gonzalez	Gonzalez	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	D.A.	D.A.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Zhang	Zhang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	D.-E.	D.-E.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	Moreau-Gachelin	Moreau-Gachelin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	F.	F.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Tenen	Tenen	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	D.G.	D.G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	1995	1995	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	Oncogene	Oncogene	NOUN	NN	Number=Sing	_	_	_	_
43	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	1549	1549	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
47	1560	1560	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
50	that	that	SCONJ	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
53	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
54	directs	directs	NOUN	NNS	Number=Plur	_	_	_	_
55	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
59	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
60	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
61	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
64	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
65	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
66	,	,	PUNCT	,	_	_	_	_	_
67	and	and	CCONJ	CC	_	_	_	_	_
68	that	that	SCONJ	IN	_	_	_	_	_
69	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
70	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
71	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
72	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
73	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
74	in	in	ADP	IN	_	_	_	_	_
75	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
76	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
77	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11983
# text = Here we show that the murine PU.1 promoter is also specifically and highly functional in B cell lines as well. Oct-1 and Oct-2 can bind specifically to a site at base pair -55 in vitro, and this site is specifically protected in B cells in vivo.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
7	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	specifically	specifically	ADV	RB	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADV	RB	_	_	_	_	_
20	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_
22	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-1	-1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
30	specifically	specifically	ADV	RB	_	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	base	base	NOUN	NN	Number=Sing	_	_	_	_
36	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	55	55	NUM	CD	NumType=Card	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	site	site	NOUN	NN	Number=Sing	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	specifically	specifically	ADV	RB	_	_	_	_	_
47	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11984
# text = We also demonstrate that two other sites contribute to promoter activity in B cells; an Sp1 binding site adjacent to the octamer site, and the PU.1 autoregulatory site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	adjacent	adjacent	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	_
29	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11985
# text = Finally, we show that the B cell coactivator OBF-1/Bob1/OCA-B is only expressed in B cells and not in myeloid cells, and that OBF-1/Bob1/OCA-B can transactivate the PU.1 promoter in HeLa and myeloid cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
10	OBF	OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-1/Bob1/	-1/Bob1ith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	OCA	Oca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	OBF	OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-1/	-1ith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	Bob1/OCA	Bob1/OCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11986
# text = This B cell restricted coactivator may be responsible for the B cell specific expression of PU.1 mediated by the octamer site.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 11987
# text = Document 0030012770 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012770	0030012770	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 11988
# text = An interferon-gamma activation sequence mediates the transcriptional regulation of the IgG Fc receptor type IC gene by interferon-gamma.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
14	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	IC	Ic	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 11989
# text = Expression of the IgG Fc receptor type I (Fc gamma RI) on myeloid cells is dramatically increased by treatment with interferon-gamma (IFN-gamma).
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
5	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
11	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
12	RI	RI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	dramatically	dramatically	ADV	RB	_	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11990
# text = We observed that Fc gamma RI transcript levels in monoblast-like U937 cells were elevated within 3 hr and peaked 12 hr after exposure to IFN-gamma.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
5	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
6	RI	RI	PROPN	NNP	Number=Sing	_	_	_	_
7	transcript	transcript	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	monoblast	monoblast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	U937	U937	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	_
19	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	peaked	peake	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	12	12	NUM	CD	NumType=Card	_	_	_	_
23	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11991
# text = Treatment of U937 with IFN-gamma for 9 hr in the presence of cycloheximide led to super-induction of Fc gamma RI expression.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	9	9	NUM	CD	NumType=Card	_	_	_	_
10	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
16	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	super	super	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
23	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
24	RI	RI	PROPN	NNP	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11992
# text = Nuclear run-on analysis revealed that the rate of Fc gamma RI transcription was increased by IFN-gamma.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADJ	JJ	Degree=Pos	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
12	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
13	RI	RI	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11993
# text = Genomic sequence upstream of the Fc gamma RIC gene was cloned and subjected to primer extension analysis, which demonstrated a single transcription initiation site without a TATA box.
1	Genomic	Genomic	ADJ	JJ	Degree=Pos	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
7	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
8	RIC	Ric	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	subjected	subject	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	primer	primer	NOUN	NN	Number=Sing	_	_	_	_
16	extension	extension	NOUN	NN	Number=Sing	_	_	_	_
17	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	without	without	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
29	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11994
# text = Transient transfections of CAT reporter gene constructs containing various Fc gamma RIC promoter sequences into U937 cells revealed that a 20-bp region surrounding the transcription start site (-7 to +13) was capable of mediating transcription initiation and that an IFN-gamma responsive element (GIRE) was present within 74 bp upstream of the transcription initiation site.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfections	transfection	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
10	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
11	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
12	RIC	Ric	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	U937	U937	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	surrounding	surround	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	start	start	NOUN	NN	Number=Sing	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	+13	+13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
37	of	of	SCONJ	IN	_	_	_	_	_
38	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
43	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
47	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
48	element	element	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	GIRE	GIRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
53	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
54	within	within	ADP	IN	_	_	_	_	_
55	74	74	NUM	CD	NumType=Card	_	_	_	_
56	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
57	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
61	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
62	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11995
# text = A 17-bp sequence between positions -51 and -35 conferred IFN-gamma responsiveness on a heterologous promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	51	51	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	35	35	NUM	CD	NumType=Card	_	_	_	_
13	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11996
# text = Double-stranded GIRE sequence, but not a scrambled sequence, was specifically bound by nuclear proteins from IFN-gamma treated U937 cells.
1	Double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	GIRE	Gire	NOUN	NN	Number=Sing	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	scrambled	scramble	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	specifically	specifically	ADV	RB	_	_	_	_	_
15	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	U937	U937	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11997
# text = Gel shift experiments further showed that the STAT1 alpha protein bound to the Fc gamma RIC GIRE in response to IFN-gamma treatment of U937 cells.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	STAT1	stat1	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
15	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
16	RIC	Ric	PROPN	NNP	Number=Sing	_	_	_	_
17	GIRE	GIRE	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	U937	U937	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11998
# text = The Fc gamma RIC GIRE is homologous to the IFN-gamma activation sequence (GAS) of the guanylate binding protein and to X box elements of class II MHC genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
3	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
4	RIC	Ric	PROPN	NNP	Number=Sing	_	_	_	_
5	GIRE	GIRE	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	guanylate	guanylate	NOUN	NN	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	X	x	VERB	VB	VerbForm=Inf	_	_	_	_
26	box	box	NOUN	NN	Number=Sing	_	_	_	_
27	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	class	class	NOUN	NN	Number=Sing	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11999
# text = Our results demonstrate that transcriptional regulation of the Fc gamma RIC gene by IFN-gamma involves the binding of STAT1 alpha to a 17-bp GAS homology in the proximal promoter.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
10	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
11	RIC	Ric	PROPN	NNP	Number=Sing	_	_	_	_
12	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
17	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
29	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12000
# text = Document 0030012790 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012790	0030012790	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12001
# text = Central nervous system-derived cells express a kappa B-binding activity that enhances human immunodeficiency virus type 1 transcription in vitro and facilitates TAR-independent transactivation by Tat.
1	Central	Central	ADJ	JJ	Degree=Pos	_	_	_	_
2	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	facilitates	facilitate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	TAR	Tar	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
28	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12002
# text = The Tat protein of human immunodeficiency virus type 1 (HIV-1) is a potent activator of long terminal repeat-directed transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	X	LS	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
18	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12003
# text = While in most cell types, activation requires interaction of Tat with the unusual transcription element TAR, astrocytic glial cells support TAR-independent transactivation of HIV-1 transcription by Tat.
1	While	while	SCONJ	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	unusual	unusual	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	element	element	NOUN	NN	Number=Sing	_	_	_	_
17	TAR	Tar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	astrocytic	astrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	TAR	Tar	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
26	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12004
# text = This alternative pathway of Tat activation is mediated by the viral enhancer, a kappa B domain capable of binding the prototypical form of the transcription factor nuclear factor kappa B (NF-kappa B) present in many cell types, including T lymphocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	prototypical	prototypical	ADJ	JJ	Degree=Pos	_	_	_	_
23	form	form	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12005
# text = Tat transactivation mediated by the kappa B domain is sufficient to allow replication of TAR-deleted mutant HIV-1 in astrocytes.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
13	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TAR	TAR	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
19	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12006
# text = The present study demonstrates the existence of kappa B-specific binding factors present in human glial astrocytes that differ from prototypical NF-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B-	B-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	glial	glial	ADJ	JJ	Degree=Pos	_	_	_	_
17	astrocytes	astrocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	prototypical	prototypical	ADJ	JJ	Degree=Pos	_	_	_	_
22	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12007
# text = The novel astrocyte-derived kappa B-binding activity is retained on an HIV-1
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	astrocyte	astrocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	retained	retain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12008
# text = Tat affinity column, while prototypical NF-kappa B from Jurkat T cells is not.
1	Tat	Tat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
3	column	column	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	while	while	SCONJ	IN	_	_	_	_	_
6	prototypical	prototypical	ADJ	JJ	Degree=Pos	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12009
# text = In vitro transcription studies demonstrate that astrocyte-derived kappa B-binding factors activate transcription of the HIV-1 long terminal repeat and that this activation is dependent on the kappa B domain.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	astrocyte	astrocyte	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
22	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
23	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12010
# text = Moreover, TAR-independent transactivation of HIV-1 transcription is reproduced in vitro in an astrocyte factor-dependent manner which correlates with kappa B-binding activity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TAR	TAR	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	reproduced	reproduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	astrocyte	astrocyte	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12011
# text = The importance of the central nervous system-enriched kappa B transcription factor in the regulation of HIV-1 expression is discussed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
6	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
7	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12012
# text = Document 0030012807 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012807	0030012807	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12013
# text = Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	YY1	YY1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Oct1	Oct1	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	downregulates	downregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12014
# text = BACKGROUND: IL-5 controls development of eosinophilia and has been shown to be involved in the pathogenesis of allergic diseases.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
7	development	development	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
22	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12015
# text = In both atopic and nonatopic asthma, elevated IL-5 has been detected in peripheral blood and the airways.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	nonatopic	nonatopic	ADJ	JJ	Degree=Pos	_	_	_	_
6	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	5	5	NUM	CD	NumType=Card	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	airways	airway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12016
# text = IL-5 is produced mainly by activated T cells, and its expression is regulated at the transcriptional level.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	mainly	mainly	ADV	RB	_	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12017
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 12018
# text = This study focuses on the functional analysis of the human IL-5 (hIL-5) promoter and characterization of cis -regulatory elements and transcription factors involved in the suppression of IL-5 transcription in T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	focuses	focus	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	5	5	NUM	CD	NumType=Card	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12019
# text = METHODS: Methods used in this study include DNase I footprint assays, electrophoretic mobility shift assays, and functional analysis by mammalian cell transfection involving deletion analysis and site-directed mutagenesis.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Methods	method	NOUN	NNS	Number=Plur	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	study	study	NOUN	NN	Number=Sing	_	_	_	_
8	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	footprint	footprint	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	assays	assays	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
15	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
26	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
27	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
28	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12020
# text = RESULTS: We identified 5 protein binding regions (BRs) located within the proximal hIL-5 promoter.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	BRs	BRs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12021
# text = Functional analysis indicates that the BRs are involved in control of hIL-5 promoter activity.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	BRs	BR	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	hIL	hIL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	5	5	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12022
# text = Two of these regions, BR3 and BR4 located at positions -102 to -73, have not previously been described as regulators of IL-5 expression in T cells.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	BR3	BR3	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	BR4	BR4	NUM	CD	NumType=Card	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	102	102	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	73	73	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	5	5	NUM	CD	NumType=Card	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12023
# text = We show that the BR3 sequence contains a novel negative regulatory element located at positions -90 to -79 of the hIL-5 promoter, which binds Oct1, octamer-like, and YY1 nuclear factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	BR3	BR3	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	90	90	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	79	79	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	Oct1	Oct1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	like	like	INTJ	UH	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	YY1	YY1	NUM	CD	NumType=Card	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12024
# text = Substitution mutations, which abolished binding of these proteins to the BR3 sequence, significantly increased hIL-5 promoter activity in activated T cells.
1	Substitution	Substitution	NOUN	NN	Number=Sing	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	BR3	BR3	NOUN	NN	Number=Sing	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	significantly	significantly	ADV	RB	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12025
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 12026
# text = We suggest that Oct1, YY1, and octamer-like factors binding to the -90/-79 sequence within the proximal IL-5 promoter are involved in suppression of IL-5 transcription in T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Oct1	oct1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	YY1	yy1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	SCONJ	IN	_	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	90/-79	90/-79	NUM	CD	NumType=Card	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	5	5	NUM	CD	NumType=Card	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12027
# text = Document 0030012808 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012808	0030012808	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12028
# text = The role of BSAP (Pax-5) in B-cell development.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Pax	Pax	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12029
# text = The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	hierarchy	hierarchy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	control	control	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12030
# text = In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	paired	paire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
30	role	role	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
33	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
34	lymphopoiesis	lymphopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12031
# text = Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
3	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	BSAP	Bsap	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
15	switching	switching	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
21	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
27	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12032
# text = Document 0030012809 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012809	0030012809	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12033
# text = Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene [published erratum appears in Mol Cell Biol 1997 Apr;17(4):2351]
1	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	_
6	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
27	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Mol	Mol	PROPN	NNP	Number=Sing	_	_	_	_
30	Cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
31	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
32	1997	1997	NUM	CD	NumType=Card	_	_	_	_
33	Apr;17	Apr;17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	:2351	:2351	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12034
# text = The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is a key regulator of lymphocyte proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12035
# text = IL-2R alpha is rapidly and potently induced in T cells in response to mitogenic stimuli.
1	IL	Il	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	rapidly	rapidly	ADV	RB	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	potently	potently	ADV	RB	_	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12036
# text = Interleukin 2 (IL-2) stimulates IL-2R alpha transcription, thereby amplifying expression of its own high-affinity receptor.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	R	r	X	GW	_	_	_	_	_
13	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	thereby	thereby	ADV	RB	_	_	_	_	_
17	amplifying	amplify	VERB	VBG	VerbForm=Ger	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
22	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12037
# text = IL-2R alpha transcription is at least in part controlled by two positive regulatory regions, PRRI and PRRII.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2R	2r	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	part	part	NOUN	NN	Number=Sing	_	_	_	_
11	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	PRRI	PRRI	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	PRRII	PRRII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12038
# text = PRRI is an inducible proximal enhancer, located between nucleotides -276 and -244, which contains NF-kappaB and SRE/CArG motifs.
1	PRRI	PRRI	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	276	276	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	244	244	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	SRE	SRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	CArG	CArG	PROPN	NNP	Number=Sing	_	_	_	_
26	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12039
# text = PRRII is a T-cell-specific enhancer, located between nucleotides -137 and -64, which binds the T-cell-specific Ets protein Elf-1 and HMG-I(Y) proteins.
1	PRRII	pRRIi	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	137	137	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	64	64	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
27	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
28	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	Y	y	ADV	WRB	PronType=Int	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12040
# text = However, none of these proximal regions account for the induction of IL-2R alpha transcription by IL-2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	none	none	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
7	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
8	account	account	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12041
# text = To find new regulatory regions of the IL-2R alpha gene, 8.5 kb of the 5' end noncoding sequence of the IL-2R alpha gene have been sequenced.
1	To	to	PART	TO	_	_	_	_	_
2	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
3	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	8.5	8.5	NUM	CD	NumType=Card	_	_	_	_
15	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	_
20	end	end	NOUN	NN	Number=Sing	_	_	_	_
21	noncoding	noncoding	NOUN	NN	Number=Sing	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	sequenced	sequence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12042
# text = We identified an 86-nucleotide fragment that is 90% identical to the recently characterized murine IL-2-responsive element (mIL-2rE).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	86	86	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
7	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	recently	recently	ADV	RB	_	_	_	_	_
16	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	mIL	mil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2rE	2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12043
# text = This putative human IL-2rE, designated PRRIII, confers IL-2 responsiveness on a heterologous promoter.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2rE	2re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	PRRIII	pRRIIi	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12044
# text = PRRIII contains a Stat protein binding site that overlaps with an EBS motif (GASd/EBSd).
1	PRRIII	Prriii	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GASd/EBSd	GASd/EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12045
# text = These are essential for IL-2 inducibility of PRRIII/CAT reporter constructs.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	PRRIII	PRRIII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
13	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
14	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12046
# text = IL-2 induced the binding of Stat5a and b proteins to the human GASd element.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	b	b	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	GASd	Gasd	PROPN	NNP	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12047
# text = To confirm the physiological relevance of these findings, we carried out in vivo footprinting experiments which showed that stimulation of IL-2R alpha expression correlated with occupancy of the GASd element.
1	To	to	PART	TO	_	_	_	_	_
2	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
5	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	carried	carry	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	out	out	ADP	RP	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
15	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
16	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	GASd	GAS	PROPN	NNP	Number=Sing	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12048
# text = Our data demonstrate a major role of the GASd/EBSd element in IL-2R alpha regulation and suggest that the T-cell-specific Elf-1 factor can serve as a transcriptional repressor.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GASd/EBSd	GASd/EBSd	PROPN	NNP	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	Elf	Elf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12049
# text = Document 0030012812 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012812	0030012812	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12050
# text = Identification of an inducible regulator of c-myb expression during T-cell activation.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12051
# text = Resting T cells express very low levels of c-Myb protein.
1	Resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	express	express	NOUN	NNS	Number=Plur	_	_	_	_
5	very	very	ADV	RB	_	_	_	_	_
6	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12052
# text = During T-cell activation, c-myb expression is induced and much of the increase in expression occurs at the transcriptional level.
1	During	during	ADP	IN	_	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	induced	induced	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12053
# text = We identified a region of the c-myb 5' flanking sequence that increased c-myb expression during T-cell activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	``	_	_	_	_	_
11	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12054
# text = In vivo footprinting by ligation-mediated PCR was performed to correlate in vivo protein binding with functional activity.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
3	footprinting	footprinting	VERB	VBG	VerbForm=Ger	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	PCR	Pcr	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12055
# text = A protein footprint was visible over this region of the c-myb 5' flanking sequence in activated T cells but not in unactivated T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	visible	visible	ADJ	JJ	Degree=Pos	_	_	_	_
6	over	over	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12056
# text = An electrophoretic mobility shift assay (EMSA) with nuclear extract from activated T cells and an oligonucleotide of this binding site demonstrated a new protein-DNA complex, referred to as CMAT for c-myb in activated T cells; this complex was not present in unactivated T cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	CMAT	CMAT	PROPN	NNP	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
40	T	T	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
45	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
46	not	not	PART	RB	_	_	_	_	_
47	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	unactivated	unactivated	ADJ	JJ	Degree=Pos	_	_	_	_
50	T	T	PROPN	NNP	Number=Sing	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12057
# text = Because the binding site showed some sequence similarity with the nuclear factor of activated T cells (NFAT) binding site, we compared the kinetics of induction of the two binding complexes and the molecular masses of the two proteins.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	some	some	DET	DT	_	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
37	masses	mass	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	two	two	NUM	CD	NumType=Card	_	_	_	_
41	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12058
# text = Studies of the kinetics of induction showed that the NFAT EMSA binding complex appeared earlier than the CMAT complex.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
11	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	complex	complex	NUM	CD	NumType=Card	_	_	_	_
14	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CMAT	Cmat	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12059
# text = The NFAT protein migrated more slowly in a sodium dodecyl sulfate-polyacrylamide gel than the CMAT protein did.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	migrated	migrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	more	more	ADV	RBR	_	_	_	_	_
6	slowly	slowly	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
10	dodecyl	dodecyl	NOUN	NN	Number=Sing	_	_	_	_
11	sulfate-	sulfate-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
13	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CMAT	CMAT	PROPN	NNP	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12060
# text = In addition, an antibody against NFAT did not cross-react with the CMAT protein.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	cross-react	cross-react	VERB	VB	VerbForm=Inf	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CMAT	Cmat	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12061
# text = The appearance of the CMAT binding complex was inhibited by both cyclosporin A and rapamycin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CMAT	CMAT	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
13	A	a	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12062
# text = The CMAT protein appears to be a novel inducible protein involved in the regulation of c-myb expression during T-cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CMAT	Cmat	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	myb	myb	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12063
# text = Document 0030012813 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012813	0030012813	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12064
# text = Unicellular-unilineage erythropoietic cultures: molecular analysis of regulatory gene expression at sibling cell level.
1	Unicellular	Unicelular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	unilineage	unilineage	ADJ	JJ	Degree=Pos	_	_	_	_
4	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	SCONJ	IN	_	_	_	_	_
14	sibling	sibl	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12065
# text = In vitro studies on hematopoietic control mechanisms have been hampered by the heterogeneity of the analyzed cell populations, ie, lack of lineage specificity and developmental stage homogeneity of progenitor/precursor cells growing in culture.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
6	control	control	NOUN	NN	Number=Sing	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	hampered	hamper	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	heterogeneity	heterogeneity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
25	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
28	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
29	homogeneity	homogeneity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12066
# text = We developed unicellular culture systems for unilineage differentiation of purified hematopoietic progenitor cells followed by daughter cell analysis at cellular and molecular level.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	unicellular	unicellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
5	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	unilineage	unilineage	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	daughter	daughter	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12067
# text = In the culture system reported here, (1) the growth factor (GF) stimulus induces cord blood (CB) progenitor cells to proliferate and differentiate/mature exclusively along the erythroid lineage; (2) this erythropoietic wave is characterized by less than 4% apoptotic cells; (3) asymmetric divisions are virtually absent, ie, nonresponsive hematopoietic progenitors with no erythropoietic potential are forced into apoptosis; (4) the system is cell division controlled (cdc), ie, the number of divisions performed by each cell is monitored.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	1	1	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GF	gf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CB	CB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	differentiate	differentiate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
32	exclusively	exclusively	ADV	RB	_	_	_	_	_
33	along	along	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
36	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	2	2	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
43	wave	wave	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
48	than	than	ADP	IN	_	_	_	_	_
49	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	%	%	SYM	NN	Number=Sing	_	_	_	_
51	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	;	;	PUNCT	,	_	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	3	3	X	LS	_	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	asymmetric	asymmetric	ADJ	JJ	Degree=Pos	_	_	_	_
58	divisions	division	NOUN	NNS	Number=Plur	_	_	_	_
59	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
60	virtually	virtually	ADV	RB	_	_	_	_	_
61	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	nonresponsive	nonresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
66	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
67	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
68	with	with	ADP	IN	_	_	_	_	_
69	no	no	DET	DT	_	_	_	_	_
70	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
71	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
72	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
73	forced	force	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
74	into	into	ADP	IN	_	_	_	_	_
75	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	;	;	PUNCT	,	_	_	_	_	_
77	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
78	4	4	X	LS	_	_	_	_	SpaceAfter=No
79	)	)	PUNCT	-RRB-	_	_	_	_	_
80	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
81	system	system	NOUN	NN	Number=Sing	_	_	_	_
82	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
83	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
84	division	division	NOUN	NN	Number=Sing	_	_	_	_
85	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
86	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
87	cdc	cdc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
89	,	,	PUNCT	,	_	_	_	_	_
90	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
91	,	,	PUNCT	,	_	_	_	_	_
92	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
93	number	number	NOUN	NN	Number=Sing	_	_	_	_
94	of	of	ADP	IN	_	_	_	_	_
95	divisions	division	NOUN	NNS	Number=Plur	_	_	_	_
96	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
97	by	by	ADP	IN	_	_	_	_	_
98	each	each	DET	DT	_	_	_	_	_
99	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
100	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
101	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
102	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12068
# text = Single-cell reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was applied to this culture system to investigate gene expression of diverse receptors, markers of differentiation, and transcription factors (EKLF, GATA-1, GATA-2, p45 NF-E2, PU.1, and SCL/Tal1) at discrete stages of erythropoietic development.
1	Single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
5	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RT-PCR	RT-PCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
19	system	system	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	p45	p45	NUM	CD	NumType=Card	_	_	_	_
47	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
56	Tal1	Tal1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	_
58	at	at	ADP	IN	_	_	_	_	_
59	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
60	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	erythropoietic	erythropoietic	ADJ	JJ	Degree=Pos	_	_	_	_
63	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12069
# text = Freshly isolated CD34(+) cells expressed CD34, c-kit, PU.1, and GATA-2 but did not express CD36, erythropoietin receptor (EpoR), SCL/Tal1, EKLF, NF-E2, GATA-1, or glyocophorin A (GPA).
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	CD34	Cd34	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	+)	+)	PUNCT	-RRB-	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	CD34	Cd34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	kit	kit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PU.1	Pu.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
23	CD36	Cd36	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	/Tal1	/Tal1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	glyocophorin	glyocophorin	NOUN	NN	Number=Sing	_	_	_	_
46	A	A	PROPN	NNP	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	GPA	gpa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12070
# text = In early to intermediate stages of erythroid differentiation we monitored the induction of CD36, Tal1, EKLF, NF-E2, and GATA-1 that preceeded expression of EpoR.
1	In	in	ADP	IN	_	_	_	_	_
2	early	early	ADV	RB	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	monitored	monitor	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	CD36	Cd36	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Tal1	Tal1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	preceeded	proceeed	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12071
# text = In late stages of erythroid maturation, GPA was upregulated, whereas CD34, c-kit, PU.1, and GATA-2 were barely or not detected.
1	In	in	ADP	IN	_	_	_	_	_
2	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
3	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
6	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	GPA	gpa	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	kit	kit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	barely	barely	ADV	RB	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12072
# text = In addition, competitive single-cell RT-PCR was used to assay CD34 mRNA transcripts in sibling CD34(+) CD38(-) cells differentiating in unilineage erythroid cultures: this analysis allowed us to semiquantitate the gradual downmodulation of CD34 mRNA from progenitor cells through their differentiating erythroid progeny.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
5	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	RT	Rt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	assay	assay	VERB	VB	VerbForm=Inf	_	_	_	_
15	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	34	34	NUM	CD	NumType=Card	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	SCONJ	IN	_	_	_	_	_
20	sibling	sibl	VERB	VBG	VerbForm=Ger	_	_	_	_
21	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	+)	+)	SYM	NFP	_	_	_	_	_
24	CD38	CD38	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(-)	(-)	PUNCT	.	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	unilineage	unilineage	ADJ	JJ	Degree=Pos	_	_	_	_
30	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	:	:	PUNCT	:	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
35	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	semiquantitate	semiquantitate	VERB	VB	VerbForm=Inf	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	gradual	gradual	ADJ	JJ	Degree=Pos	_	_	_	_
41	downmodulation	downmodulation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	34	34	NUM	CD	NumType=Card	_	_	_	_
45	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
46	from	from	ADP	IN	_	_	_	_	_
47	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	through	through	ADP	IN	_	_	_	_	_
50	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
51	differentiating	differentiat	NOUN	NN	Number=Sing	_	_	_	_
52	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
53	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12073
# text = It is concluded that this novel culture system, coupled with single-cell RT-PCR analysis, may eliminate the ambiguities intrinsic to molecular studies on heterogeneous populations of hematopoietic progenitors/precursors growing in culture, particularly in the initial stages of development.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
8	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	RT	Rt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	eliminate	eliminate	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ambiguities	ambiguity	NOUN	NNS	Number=Plur	_	_	_	_
24	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
27	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
30	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
33	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
36	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	particularly	particularly	ADV	RB	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
44	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12074
# text = Document 0030012817 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012817	0030012817	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12075
# text = Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12076
# text = Engagement of surface immunoglobulin on mature B cells leads to rescue from apoptosis and to proliferation.
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
4	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	rescue	rescue	VERB	VB	VerbForm=Inf	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12077
# text = Levels of bcl-2 mRNA and protein increase with cross-linking of surface immunoglobulin.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
15	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12078
# text = We have located the major positive regulatory region for control of bcl-2 expression in B cells in the 5'-flanking region.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	'	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	flanking	flanking	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12079
# text = The positive region can be divided into an upstream and a downstream regulatory region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	divided	divide	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12080
# text = The downstream regulatory region contains a cyclic AMP-responsive element (CRE).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
8	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CRE	CRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12081
# text = We show by antibody supershift experiments and UV cross-linking followed by denaturing polyacrylamide gel electrophoresis that both CREB and ATF family members bind to this region in vitro.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
5	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
6	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	UV	UV	NOUN	NN	Number=Sing	_	_	_	_
9	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
11	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	denaturing	denatur	VERB	VBG	VerbForm=Ger	_	_	_	_
14	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
15	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
16	electrophoresis	electrophoresis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	ATF	ATF	ADJ	JJ	Degree=Pos	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	members	member	NOUN	NNS	Number=Plur	_	_	_	_
24	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12082
# text = Mutations of the CRE site that result in loss of CREB binding also lead to loss of functional activity of the bcl-2 promoter in transient-transfection assays.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CRE	CRE	ADJ	JJ	Degree=Pos	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	result	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	lead	lead	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
30	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12083
# text = The presence of an active CRE site in the bcl-2 promoter implies that the regulation of bcl-2 expression is linked to a signal transduction pathway in B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	implies	imply	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
28	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
29	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12084
# text = Treatment of the mature B-cell line BAL-17 with either anti-immunoglobulin M or phorbol 12-myristate 13-acetate leads to an increase in bcl-2 expression that is mediated by the CRE site.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	BAL	Bal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	17	17	NUM	CD	NumType=Card	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	either	either	DET	DT	_	_	_	_	_
14	anti-immunoglobulin	anti-immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
15	M	m	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
21	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
24	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	CRE	Cre	ADJ	JJ	Degree=Pos	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12085
# text = Treatment of the more immature B-cell line, Ramos, with phorbol esters rescues the cells from calcium-dependent apoptosis.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	more	more	ADV	RBR	_	_	_	_	_
5	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Ramos	Ramos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
16	rescues	rescue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12086
# text = bcl-2 expression is increased following phorbol ester treatment, and the increased expression is dependent on the CRE site.
1	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
10	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CRE	Cre	ADJ	JJ	Degree=Pos	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12087
# text = These stimuli result in phosphorylation of CREB at serine 133.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
3	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
10	133	133	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12088
# text = The phosphorylation of CREB that results in activation is mediated by protein kinase C rather than by protein kinase A.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	C	c	NOUN	NN	Number=Sing	_	_	_	_
15	rather	rather	ADV	RB	_	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	A	A	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12089
# text = Although the CRE site is necessary, optimal induction of bcl-2 expression requires participation of the upstream regulatory element, suggesting that phosphorylation of CREB alters its interaction with the upstream regulatory element.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	CRE	CRE	NOUN	NN	Number=Sing	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
28	alters	alter	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12090
# text = The CRE site in the bcl-2 promoter appears to play a major role in the induction of bcl-2 expression during the activation of mature B cells and during the rescue of immature B cells from apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CRE	Cre	ADJ	JJ	Degree=Pos	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	during	during	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12091
# text = It is possible that the CRE site is responsible for induction of bcl-2 expression in other cell types, particularly those in which protein kinase C is involved.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	particularly	particularly	ADV	RB	_	_	_	_	_
23	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	which	which	DET	WDT	PronType=Int	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	C	c	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12092
# text = Document 0030012824 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012824	0030012824	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12093
# text = Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha:
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor-kappaB	factor-kappab	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 12094
# text = evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation.
1	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
5	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	activating	activate	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12095
# text = Tumor necrosis factor alpha (TNFalpha) is a pluripotent activator of inflammation by inducing a proinflammatory cytokine cascade.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	pluripotent	pluripotent	ADJ	JJ	Degree=Pos	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12096
# text = This phenomenon is mediated, in part, through inducible expression of the CXC chemokine, interleukin-8 (IL-8).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CXC	CXC	PROPN	NNP	Number=Sing	_	_	_	_
15	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8	8	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12097
# text = In this study, we investigate the role of TNFalpha-inducible reactive oxygen species (ROS) in IL-8 expression by "monocyte-like" U937 histiocytic lymphoma cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
14	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
15	species	species	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	ROS	Ros	X	ADD	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	8	8	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
26	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	INTJ	UH	_	_	_	_	SpaceAfter=No
29	"	"	PUNCT	``	_	_	_	_	_
30	U937	U937	NUM	CD	NumType=Card	_	_	_	_
31	histiocytic	histiocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12098
# text = TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
5	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	8	8	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12099
# text = In gene transfection assays, the effect of TNFalpha requires the presence of an inducible nuclear factor-kappaB (NF-kappaB) (Rel A) binding site in the IL-8 promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
26	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	8	8	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12100
# text = TNFalpha treatment induces a rapid translocation of the 65 kD transcriptional activator NF-kappaB subunit, Rel
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
6	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	65	65	NUM	CD	NumType=Card	_	_	_	_
10	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12101
# text = A, whose binding in the nucleus occurs before changes in intracellular ROS.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nucleus	nucleus	ADJ	JJ	Degree=Pos	_	_	_	_
8	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
9	before	before	ADP	IN	_	_	_	_	_
10	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12102
# text = Pretreatment (or up to 15 minutes posttreatment) relative to TNFalpha with the antioxidant dimethyl sulfoxide (DMSO) (2% [vol/vol]) blocks 80% of NF-kappaB-dependent transcription.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	or	or	CCONJ	CC	_	_	_	_	_
4	up	up	ADV	RB	_	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	15	15	NUM	CD	NumType=Card	_	_	_	_
7	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
8	posttreatment	posttreatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	relative	relative	ADV	RB	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
16	dimethyl	dimethyl	NOUN	NN	Number=Sing	_	_	_	_
17	sulfoxide	sulfoxide	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	%	%	SYM	NN	Number=Sing	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	vol	vol	INTJ	UH	_	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	vol	vol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
31	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	%	%	SYM	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12103
# text = Surprisingly, however, DMSO has no effect on inducible Rel A binding.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12104
# text = Similar selective effects on NF-kappaB transcription are seen with the unrelated antioxidants, N-acetylcysteine (NAC) and vitamin C.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	unrelated	unrelated	ADJ	JJ	Degree=Pos	_	_	_	_
14	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	acetylcysteine	acetylcysteine	PRON	PRP	_	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	vitamin	vitamin	PROPN	NNP	Number=Sing	_	_	_	_
23	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12105
# text = These data indicate that TNFalpha induces a delayed ROS-dependent signalling pathway that is required for NF-kappaB transcriptional activation and is separable from that required for its nuclear translocation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
6	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
9	ROS	Ros	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	separable	separable	ADJ	JJ	Degree=Pos	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12106
# text = Further definition of this pathway will yield new insights into inflammation initiated by TNFalpha signalling.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	definition	definition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	will	will	AUX	MD	VerbForm=Fin	_	_	_	_
7	yield	yield	VERB	VB	VerbForm=Inf	_	_	_	_
8	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
9	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
12	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
15	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12107
# text = Document 0030012826 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012826	0030012826	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12108
# text = Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner.
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
24	A	a	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12109
# text = Cyclosporin A (CsA) is thought to exert its immunosuppressive effects by inhibiting the expression of a distinct set of lymphokine genes which are induced upon T-cell activation, among them the gene coding for interleukin-2.
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
2	A	a	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	set	set	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	upon	upon	ADP	IN	_	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	among	among	ADP	IN	_	_	_	_	_
33	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12110
# text = In addition, the activation of the human immunodeficiency virus (HIV) is partially suppressed.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	partially	partially	ADV	RB	_	_	_	_	_
16	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12111
# text = To better understand the molecular mechanisms underlying suppression by CsA, we have investigated the effects of this drug on transcription factors in T cells.
1	To	to	ADP	IN	_	_	_	_	_
2	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
3	understand	understand	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	underlying	underly	ADJ	JJ	Degree=Pos	_	_	_	_
8	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12112
# text = Here we report that the formation of two distinct mitogen-inducible DNA-binding complexes, the kappa B complex within the HIV enhancer and the NFAT-1 complex within the interleukin-2 enhancer, is inhibited in the presence of CsA.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
22	within	within	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
25	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
32	within	within	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12113
# text = The kappa B-binding activity with the HIV enhancer is inhibited only if it is activated via the mitogen phytohemagglutinin whereas phorbol myristate acetate-mediated activation is completely insensitive to the drug.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
3	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	if	if	SCONJ	IN	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mitogen	mitogen	ADJ	JJ	Degree=Pos	_	_	_	_
20	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
23	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
24	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	completely	completely	ADV	RB	_	_	_	_	_
30	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12114
# text = This suggests a model in which functionally indistinguishable kappa B complexes can be activated via two separate pathways of signal transduction distinguishable by CsA.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	functionally	functionally	ADV	RB	_	_	_	_	_
8	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	via	via	ADP	IN	_	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
21	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
22	distinguishable	distinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12115
# text = Document 0030012828 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012828	0030012828	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12116
# text = GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.
1	GrpL	Grpl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	Grb2	grb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	76	76	NUM	CD	NumType=Card	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12117
# text = Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules.
1	Propagation	Propagation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	T	T	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	number	number	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12118
# text = SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor
1	SH2	SH2	NUM	CD	NumType=Card	_	_	_	_
2	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	76	76	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	SLP	sLp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	76	76	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
16	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
17	exchange	exchange	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12119
# text = Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development.
1	Vav	Vave	VERB	VB	Abbr=Yes|VerbForm=Inf	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12120
# text = We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	Grb2	grb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
15	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	Grb2	grb2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	GrpL	GrpL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12121
# text = Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	GrpL	GrpL	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
8	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	distinguished	distinguish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	Grb2	Grb2	NUM	CD	NumType=Card	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	proline-rich	proline-rich	ADJ	JJ	Degree=Pos	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12122
# text = GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates.
1	GrpL	Grpl	NOUN	NN	Number=Sing	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	coimmunoprecipitated	coimmunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	SLP	sLp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	76	76	NUM	CD	NumType=Card	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	Sos1	Sos1	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	Sos2	Sos2	NUM	CD	NumType=Card	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12123
# text = In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Grb2	grb2	NOUN	NN	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	coimmunoprecipitated	coimmunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	Sos1	Sos1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Sos2	Sos2	NUM	CD	NumType=Card	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	76	76	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12124
# text = Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tyrosine	tyrosine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	phosphorylated	phosphorylated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LAT	Lat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	pp36/38	pp36/38	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	detergent	detergent	ADJ	JJ	Degree=Pos	_	_	_	_
11	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
12	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	Grb2	Grb2	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	GrpL	Grpl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12125
# text = These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
10	GrpL	Grpl	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Grb2	Grb2	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12126
# text = A functional role of the GrpL-SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	GrpL	GrpL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	SLP	SLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	76	76	NUM	CD	NumType=Card	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GrpL	GrpL	PROPN	NNP	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
21	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	SLP	SLP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	76	76	NUM	CD	NumType=Card	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	augment	augment	NOUN	NN	Number=Sing	_	_	_	_
31	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	AT	at	ADP	IN	_	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
37	T	T	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12127
# text = Document 0030012829 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012829	0030012829	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12128
# text = Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.
1	Epithelial	Epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
6	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
13	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	amebic	amebic	ADJ	JJ	Degree=Pos	_	_	_	_
16	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	intestine	intestine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12129
# text = BACKGROUND & AIMS: Entamoeba histolytica infection of the intestine can induce severe gut inflammation.
1	BACKGROUND	background	PROPN	NNP	Number=Sing	_	_	_	_
2	&	&	CCONJ	CC	_	_	_	_	_
3	AIMS	aim	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Entamoeba	Entamoeba	PROPN	NNP	Number=Sing	_	_	_	_
6	histolytica	histolytica	NOUN	NN	Number=Sing	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	intestine	intestine	NOUN	NN	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
14	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
15	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12130
# text = The aims of this study were to assess the role of the host inflammatory response in the tissue damage observed with amebiasis and the role of the intestinal epithelial cell in initiating that response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aims	aim	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	were	be	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	host	host	ADV	RBS	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
19	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	amebiasis	amebiasis	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
29	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	SCONJ	IN	_	_	_	_	_
32	initiating	initiat	VERB	VBG	VerbForm=Ger	_	_	_	_
33	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12131
# text = METHODS: E. histolytica infection was established in human intestinal xenografts in severe combined immunodeficient (SCID-HU-INT) mice.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	E.	e.	PROPN	NNP	Number=Sing	_	_	_	_
4	histolytica	histolytican	NOUN	NN	Number=Sing	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
11	xenografts	xenograft	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
14	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	immunodeficient	immunodeficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	SCID	Scid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	HU-	Hu-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	INT	INT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12132
# text = Human intestinal epithelial cell inflammatory responses to amebic infection were inhibited by the intraluminal administration of an antisense oligonucleotide to the human p65 subunit of nuclear factor kappaB, and the role of neutrophils in tissue damage observed with amebiasis was studied by depleting neutrophils from SCID-HU-INT mice.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
3	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	amebic	amebic	ADJ	JJ	Degree=Pos	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	intraluminal	intraluminal	ADJ	JJ	Degree=Pos	_	_	_	_
15	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
19	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
24	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
37	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
38	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	amebiasis	amebiasis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	by	by	SCONJ	IN	_	_	_	_	_
44	depleting	deplet	VERB	VBG	VerbForm=Ger	_	_	_	_
45	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
46	from	from	ADP	IN	_	_	_	_	_
47	SCID	SCID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	INT	Int	ADJ	JJ	Degree=Pos	_	_	_	_
52	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12133
# text = RESULTS:
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 12134
# text = Administration of the antisense oligonucleotide blocked the production of human interleukin 1beta and interleukin 8 by intestinal epithelial cells and inhibited neutrophil influx into the E.
1	Administration	Administration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
5	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
6	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
16	8	8	NUM	CD	NumType=Card	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
19	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
24	influx	influx	NOUN	NN	Number=Sing	_	_	_	_
25	into	into	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12135
# text = histolytica-infected intestinal xenografts.
1	histolytica	histolytican	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
2	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
4	xenografts	xenograft	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12136
# text = Inhibition of the gut inflammatory response by the antisense oligonucleotide or the depletion of neutrophils from SCID-HU- INT mice blocked the increase in intestinal permeability observed with amebic infection.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	gut	gut	ADJ	JJ	Degree=Pos	_	_	_	_
5	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
10	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	SCID	SCID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	HU	Hu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	_
21	INT	Int	PROPN	NNP	Number=Sing	_	_	_	_
22	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
23	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
28	permeability	permeability	NOUN	NN	Number=Sing	_	_	_	_
29	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	amebic	amebic	ADJ	JJ	Degree=Pos	_	_	_	_
32	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12137
# text = CONCLUSIONS: Intestinal epithelial cells initiate an inflammatory response with resulting neutrophil-mediated tissue damage in response to E. histolytica infection; this inflammatory cascade can be blocked by inhibiting the transcription of genes regulated by nuclear factor kappaB.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Intestinal	Intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
4	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	initiate	initiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	SCONJ	IN	_	_	_	_	_
11	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
12	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
16	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	E.	e.	PROPN	NNP	Number=Sing	_	_	_	_
21	histolytica	histolytica	PROPN	NNP	Number=Sing	_	_	_	_
22	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
27	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	SCONJ	IN	_	_	_	_	_
31	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
40	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12138
# text = Document 0030012841 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012841	0030012841	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12139
# text = Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Max	Max	PROPN	NNP	Number=Sing	_	_	_	_
5	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12140
# text = T cell hybridomas respond to activation signals by undergoing apoptotic cell death, and this is likely to represent comparable events related to tolerance induction in immature and mature T cells in vivo.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	_
4	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
10	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
20	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
21	events	event	NOUN	NNS	Number=Plur	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12141
# text = Previous studies using antisense oligonucleotides implicated the c-Myc protein in the phenomenon of activation-induced apoptosis.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
5	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
6	implicated	implicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12142
# text = This role for c-Myc in apoptosis is now confirmed in studies using a dominant negative form of its heterodimeric binding partner, Max, which we show here inhibits activation-induced apoptosis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	now	now	ADV	RB	_	_	_	_	_
11	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	form	form	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	heterodimeric	heterodimeric	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	partner	partner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Max	Max	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
29	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	here	here	ADV	RB	PronType=Dem	_	_	_	_
31	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12143
# text = Further, coexpression of a reciprocally mutant Myc protein capable of forming functional heterodimers with the mutant Max can compensate for the dominant negative activity and restore activation-induced apoptosis.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	reciprocally	reciprocally	ADV	RB	_	_	_	_	_
7	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
8	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
11	of	of	SCONJ	IN	_	_	_	_	_
12	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
18	Max	Max	PROPN	NNP	Number=Sing	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	compensate	compensate	VERB	VB	VerbForm=Inf	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12144
# text = These results imply that Myc promotes activation-induced apoptosis by obligatory heterodimerization with Max, and therefore, by regulating gene transcription.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
6	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	obligatory	obligatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	heterodimerization	heterodimerization	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	Max	Max	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12145
# text = Document 0030012842 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012842	0030012842	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12146
# text = A novel heterodimerization partner for thyroid hormone receptor.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	heterodimerization	heterodimerization	NOUN	NN	Number=Sing	_	_	_	_
4	partner	partner	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
7	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12147
# text = Peroxisome proliferator-activated receptor.
1	Peroxisome	Peroxisome	DET	DT	_	_	_	_	_
2	proliferator	proliferator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12148
# text = Retinoid-like receptors play a central role in hormonal responses by forming heterodimers with other nuclear hormone receptors.
1	Retinoid	Retinoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
5	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	forming	form	VERB	VBG	VerbForm=Ger	_	_	_	_
14	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
19	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12149
# text = In this study we have identified the peroxisome proliferator-activated receptor (PPAR) as a new thyroid hormone receptor (THR) auxiliary nuclear protein, heterodimerizing with THR in solution.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	peroxisome	peroxisome	ADJ	JJ	Degree=Pos	_	_	_	_
9	proliferator	proliferator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PPAR	PPAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
19	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
20	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	THR	Thr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	auxiliary	auxiliary	ADJ	JJ	Degree=Pos	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	heterodimerizing	heterodimerize	VERB	VBG	VerbForm=Ger	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	THR	Thr	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	solution	solution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12150
# text = Although these heterodimers do not recognize a classical thyroid hormone response element (TRE) characterized by direct repeat separated by four nucleotides (DR+4), PPAR behaves as a dominant negative regulator of thyroid hormone (TH) action.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
4	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	recognize	recognize	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
9	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
10	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TRE	tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
19	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
20	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	four	four	NUM	CD	NumType=Card	_	_	_	_
23	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	PPAR	PPAR	PROPN	NNP	Number=Sing	_	_	_	_
31	behaves	behave	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
35	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
39	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	TH	th	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12151
# text = However, a TH-dependent positive effect is elicited by selective interaction of the THR beta-PPAR but not the THR alpha-PPAR heterodimer with a novel TRE (DR+2).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	TH	th	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
13	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	THR	Thr	PROPN	NNP	Number=Sing	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	PPAR	Ppar	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	THR	Thr	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	PPAR	Ppar	NOUN	NN	Number=Sing	_	_	_	_
27	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
31	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	DR	dr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12152
# text = The critical region of THR beta was mapped to 3 amino acids in the distal box of the DNA binding domain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	THR	Thr	NOUN	NN	Number=Sing	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	amino	amino	DET	DT	_	_	_	_	_
12	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
16	box	box	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12153
# text = Hence, PPAR can positively or negatively influence TH action depending on TRE structure and THR isotype.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PPAR	PPAR	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	positively	positively	ADV	RB	_	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	negatively	negatively	ADV	RB	_	_	_	_	_
8	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
9	TH	th	NOUN	NN	Number=Sing	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
14	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	THR	Thr	NOUN	NN	Number=Sing	_	_	_	_
17	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12154
# text = Document 0030012845 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012845	0030012845	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12155
# text = Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner.
1	Purification	Purification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	C	c	X	GW	_	_	_	_	_
22	alpha	alpha	ADV	RB	_	_	_	_	_
23	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12156
# text = The differentiation of T cells into functionally diverse subpopulations is controlled in part, by transcriptional activation and silencing; however, little is known in detail about the proteins that influence this developmental process.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	functionally	functionally	ADV	RB	_	_	_	_	_
8	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
9	subpopulations	subpopulation	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	silencing	silencing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	detail	detail	NOUN	NN	Number=Sing	_	_	_	_
28	about	about	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	influence	influence	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
35	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12157
# text = We have purified a new T-cell-specific factor, TCF-1 alpha, that is implicated in the activation of genes encoding a major component of the human T-cell receptor (TCR).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	implicated	implicated	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
28	component	component	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12158
# text = TCF-1 alpha, originally identified and purified through its binding sites on the HIV-1 promoter, was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta).
1	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	originally	originally	ADV	RB	_	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
35	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
36	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	significantly	significantly	ADV	RB	_	_	_	_	_
39	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
40	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	development	development	NOUN	NN	Number=Sing	_	_	_	_
45	than	than	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	TCR	Tcr	PROPN	NNP	Number=Sing	_	_	_	_
48	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
49	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	p56lck	p56lck	NOUN	NN	Number=Sing	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
56	delta	delta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12159
# text = Sequences related to the TCF-1 alpha binding motif (5'-GGCACCCTTTGA-3') are also found in the human TCR delta (and possibly TCR beta) enhancers.
1	Sequences	Sequences	NOUN	NNS	Number=Plur	_	_	_	_
2	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'-GGCACCCTTTGA	'-GGCACCCTTTGa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	_
25	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	and	and	CCONJ	CC	_	_	_	_	_
28	possibly	possibly	ADV	RB	_	_	_	_	_
29	TCR	Tcr	ADJ	JJR	Degree=Cmp	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12160
# text = Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines (Jurkat, CCRF-CEM) and not in mature B cells (JY, Namalwa) or nonlymphoid (HeLa) cell lines.
1	Southwestern	southwestern	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	gel	gel	ADJ	JJ	Degree=Pos	_	_	_	_
4	renaturation	renaturation	NOUN	NN	Number=Sing	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	use	use	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
13	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	57	57	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	53	53	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kD	k	NOUN	NN	Number=Sing	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	abundantly	abundantly	ADV	RB	_	_	_	_	_
36	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
41	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	CCRF	CCRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	not	not	ADV	RB	_	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
55	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
56	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	JY	JY	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	Namalwa	Namalwa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	_
62	or	or	CCONJ	CC	_	_	_	_	_
63	nonlymphoid	nonlymphoid	NOUN	NN	Number=Sing	_	_	_	_
64	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
65	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	)	)	PUNCT	-RRB-	_	_	_	_	_
67	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
68	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12161
# text = A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif) and the binding site for a distinct lymphoid-specific protein (TCF-2 alpha) behaved as a potent T-cell-specific enhancer in vivo.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
6	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	control	control	NOUN	NN	Number=Sing	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	juxtaposed	juxtapose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	between	between	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	T	T	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	ADV	RB	_	_	_	_	_
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
41	site	site	NOUN	NN	Number=Sing	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
45	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
47	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	2	2	NUM	CD	NumType=Card	_	_	_	_
52	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	behaved	behave	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	as	as	ADP	IN	_	_	_	_	_
56	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
57	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
58	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
62	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12162
# text = Tandem copies of this enhancer functioned synergistically in mature (Jurkat) T-cell lines as well as resting and activated immature (CCRF-CEM) T-cell lines.
1	Tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
2	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	functioned	function	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	synergistically	synergistically	ADV	RB	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mature	mature	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	immature	immature	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	CCRF	CCRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12163
# text = Mutation of the TCF-1 alpha binding site diminished enhancer activity and disrupted the synergism observed in vivo between tandem enhancer repeats.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	disrupted	disrupt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
17	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
20	between	between	ADP	IN	_	_	_	_	_
21	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
22	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
23	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12164
# text = The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells, confirming that TCF-1 alpha is a T-cell-specific transcription factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	TCR	Tcr	ADJ	JJR	Degree=Cmp	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
18	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
19	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	confirming	confirm	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12165
# text = Curiously, the TCF-1 alpha binding element was inactive in vivo when removed from its neighboring elements on the TCR alpha enhancer and positioned in one or more copies upstream of a heterologous promoter.
1	Curiously	Curiously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	removed	remove	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	neighboring	neighbor	VERB	VBG	VerbForm=Ger	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	ADP	IN	_	_	_	_	_
24	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	positioned	position	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	one	one	NUM	CD	NumType=Card	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
31	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
32	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12166
# text = Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 (CREB) transcription factors and the context of its binding site within the TCR alpha enhancer.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CREB	CREB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	context	context	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	_
36	within	within	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
39	alpha	alpha	ADP	IN	_	_	_	_	_
40	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12167
# text = Document 0030012850 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012850	0030012850	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12168
# text = Induction of CIITA and modification of in vivo HLA-DR promoter occupancy in normal thymic epithelial cells treated with IFN-gamma: similarities and distinctions with respect to HLA-DR-constitutive B cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	_
9	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
17	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	:	:	PUNCT	:	_	_	_	_	_
25	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	distinctions	distinction	NOUN	NNS	Number=Plur	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	DR-	DR-	SYM	NFP	_	_	_	_	SpaceAfter=No
34	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
35	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12169
# text = In this study, the IFN-gamma induction of MHC class II gene expression in primary cultures of thymic epithelial cells (TEC) was analyzed.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
18	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
21	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TEC	TEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12170
# text = This cellular system offers the advantage that MHC class II induction is studied in a "physiologic" cell lineage that, as a result of this expression within the thymus, is thought to participate to the selection and maturation of the T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	system	system	NOUN	NN	Number=Sing	_	_	_	_
4	offers	offer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
17	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	"	"	PUNCT	''	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	result	result	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	within	within	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12171
# text = It was found that the MHC class II gene expression was associated with the de novo transcription of the gene encoding the CIITA trans-activator, a crucial MHC class II gene regulatory factor.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	de	de	NOUN	NN	Number=Sing	_	_	_	_
16	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
24	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
30	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
31	class	class	NOUN	NN	Number=Sing	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12172
# text = Furthermore, the anatomy of interaction between the MHC class II DRA promoter and corresponding binding factors was analyzed by in vivo DNAse I footprint.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	anatomy	anatomy	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	corresponding	correspond	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
23	DNAse	DNAse	NOUN	NN	Number=Sing	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	footprint	footprint	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12173
# text = It was found that treatment with IFN-gamma induces changes in the occupancy of the DRA gene regulatory sequences by nuclear factors.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
19	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12174
# text = The resulting occupancy displays strong similarities with the one observed in the MHC class II-constitutive
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
3	occupancy	occupancy	NOUN	NN	Number=Sing	_	_	_	_
4	displays	display	NOUN	NNS	Number=Plur	_	_	_	_
5	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
6	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	one	one	NOUN	NN	Number=Sing	_	_	_	_
10	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	constitutive	constitutive	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12175
# text = B cells, represented by both the Burkitt lymphoma line Raji and normal tonsil- derived B cells.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	represented	represent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	tonsil	tonsil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12176
# text = However, some peculiar differences were observed between the TEC, either IFN-gamma-induced or not, and the constitutive B cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	some	some	DET	DT	_	_	_	_	_
4	peculiar	peculiar	ADJ	JJ	Degree=Pos	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TEC	Tec	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	IFN-	IFN-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12177
# text = These results suggest that both common mechanisms, such as the one mediated by the CIITA trans-activator, and distinct tissue-specific constraints contribute to the transcriptional control of constitutive and IFN-gamma-induced MHC class II gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	one	one	NOUN	NN	Number=Sing	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CIITA	CIITA	NOUN	NN	Number=Sing	_	_	_	_
17	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	tissue-	tissue-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	constraints	constraint	NOUN	NNS	Number=Plur	_	_	_	_
26	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	IFN-gamma	IFN-gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
38	class	class	NOUN	NN	Number=Sing	_	_	_	_
39	II	ii	NUM	CD	NumType=Card	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12178
# text = Document 0030012854 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012854	0030012854	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12179
# text = Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	SCID	Scid	NOUN	NN	Number=Sing	_	_	_	_
14	chimeras	chimera	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12180
# text = Giant cell arteritis (GCA) is a vasculitic syndrome that preferentially affects medium and large-sized arteries.
1	Giant	giant	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	GCA	GCA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	vasculitic	vasculitic	ADJ	JJ	Degree=Pos	_	_	_	_
10	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	preferentially	preferentially	ADV	RB	_	_	_	_	_
13	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	medium	medium	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	large	large	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	sized	size	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	arteries	artery	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12181
# text = Glucocorticoid therapy resolves clinical symptoms within hours to days, but therapy has to be continued over several years to prevent disease relapses.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
3	resolves	resolf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
5	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	continued	continue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	over	over	ADP	IN	_	_	_	_	_
18	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
19	years	year	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
23	relapses	relaps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12182
# text = It is not known whether and how glucocorticoids affect the function of the inflammatory infiltrate or why the disease persists subclinically despite chronic treatment.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	how	how	ADV	WRB	PronType=Int	_	_	_	_
8	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
9	affect	affect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	infiltrate	infiltrate	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	why	why	ADV	WRB	PronType=Int	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
20	persists	persist	NOUN	NNS	Number=Plur	_	_	_	_
21	subclinically	subclinically	ADV	RB	_	_	_	_	_
22	despite	despite	ADP	IN	_	_	_	_	_
23	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
24	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12183
# text = GCA is self-sustained in temporal arteries engrafted into SCID mice, providing a model in which the mechanisms of action and limitations of glucocorticoid therapy can be examined in vivo.
1	GCA	GCa	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
8	arteries	arteries	NOUN	NNS	Number=Plur	_	_	_	_
9	engrafted	engraft	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	SCID	Scid	NOUN	NN	Number=Sing	_	_	_	_
12	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	model	model	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	action	action	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	limitations	limitation	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
28	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12184
# text = Administration of dexamethasone to temporal artery-SCID chimeras for 1 wk induced a partial suppression of T cell and macrophage function as indicated by the reduced tissue concentrations of IL-2, IL-1beta, and IL-6 mRNA, and by the diminished expression of inducible NO synthase.
1	Administration	Administration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
6	artery	artery	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	SCID	Scid	NOUN	NN	Number=Sing	_	_	_	_
9	chimeras	chimera	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	wk	wk	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
16	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	function	function	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
29	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	6	6	NUM	CD	NumType=Card	_	_	_	_
44	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	diminished	diminished	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
53	NO	no	ADJ	JJ	Degree=Pos	_	_	_	_
54	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12185
# text = In contrast, synthesis of IFN-gamma mRNA was only slightly decreased, and expression of TGF-beta1 was unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	slightly	slightly	ADV	RB	_	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12186
# text = These findings correlated with activation of the IkappaBalpha gene and blockade of the nuclear translocation of NFkappaB in the xenotransplanted tissue.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	xenotransplanted	xenotransplant	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12187
# text = Dose-response experiments suggested that steroid doses currently used in clinical medicine are suboptimal in repressing NFkappaB-mediated cytokine production in the inflammatory lesions.
1	Dose	Dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
9	currently	currently	ADV	RB	_	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
13	medicine	medicine	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	suboptimal	suboptimal	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	repressing	repress	VERB	VBG	VerbForm=Ger	_	_	_	_
18	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
22	production	production	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12188
# text = Chronic steroid therapy was able to deplete the T cell products IL-2 and IFN-gamma, whereas the activation of tissue-infiltrating macrophages was only partially affected.
1	Chronic	Chronic	PROPN	NNP	Number=Sing	_	_	_	_
2	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	deplete	deplete	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	products	product	NOUN	NNS	Number=Plur	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	infiltrating	infiltrat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	partially	partially	ADV	RB	_	_	_	_	_
30	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12189
# text = IL-1beta transcription was abrogated; in contrast, TGF-beta1 mRNA synthesis was steroid resistant.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	;	;	PUNCT	,	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
14	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12190
# text = The persistence of TGF-beta1-transcribing macrophages, despite paralysis of T cell function, may provide an explanation for the chronicity of the disease, and may identify a novel therapeutic target in this inflammatory vasculopathy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta1	beta1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	transcribing	transcribing	VERB	VBG	VerbForm=Ger	_	_	_	_
9	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	despite	despite	ADP	IN	_	_	_	_	_
12	paralysis	paralysis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	chronicity	chronicity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
34	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
35	target	target	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
39	vasculopathy	vasculopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12191
# text = Document 0030012875 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012875	0030012875	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12192
# text = Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	vacuolar	vacuolar	ADJ	JJ	Degree=Pos	_	_	_	_
6	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(+)	(+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	ATPase	ATPase	INTJ	UH	_	_	_	_	_
10	B2	B2	NUM	CD	NumType=Card	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12193
# text = Monocyte-macrophage differentiation was used as a model system for studying gene regulation of the human vacuolar H(+)-ATPase (V-ATPase).
1	Monocyte	Monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	model	model	NOUN	NN	Number=Sing	_	_	_	_
10	system	system	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	SCONJ	IN	_	_	_	_	_
12	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
13	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	vacuolar	vacuolar	ADJ	JJ	Degree=Pos	_	_	_	_
19	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(+)	(+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	ATPase	ATPase	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	V-	v-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	ATPase	ATPase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12194
# text = We examined mRNA levels of various V-ATPase subunits during differentiation of both native monocytes and the cell line THP-1, and found that transcriptional and post-transcriptional mechanisms could account for increases in cell V-ATPase content.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
7	V	V	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	ATPase	ATPase	NOUN	NN	Number=Sing	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	post	post	X	AFX	_	_	_	_	SpaceAfter=No
31	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
33	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
34	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
39	V	V	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	AT	AT	ADP	IN	_	_	_	_	SpaceAfter=No
42	Pase	Pase	NOUN	NN	Number=Sing	_	_	_	_
43	content	content	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12195
# text = From nuclear runoff experiments, we found that one subunit in particular, the B2 isoform (Mr = 56,000), was amplified primarily by transcriptional means.
1	From	from	ADP	IN	_	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	runoff	runoff	NOUN	NN	Number=Sing	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	one	one	NUM	CD	NumType=Card	_	_	_	_
10	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
16	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	Mr	mr	NOUN	NN	Number=Sing	_	_	_	_
19	=	=	SYM	SYM	_	_	_	_	_
20	56,000	56,000	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	amplified	amplify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	primarily	primarily	ADV	RB	_	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	means	means	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12196
# text = We have begun to examine the structure of the B2 subunit promoter region.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	begun	begin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12197
# text = Isolation and sequencing of the first exon and 5'-flanking region of this gene reveal a TATA-less promoter with a high G + C content.
1	Isolation	Isolation	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	less	less	ADJ	JJ	Degree=Pos	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
26	G	g	NOUN	NN	Number=Sing	_	_	_	_
27	+	+	SYM	SYM	_	_	_	_	_
28	C	c	NOUN	NN	Number=Sing	_	_	_	_
29	content	content	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12198
# text = Primer extension and ribonuclease protection analyses indicate a single major transcriptional start site.
1	Primer	Primer	NOUN	NN	Number=Sing	_	_	_	_
2	extension	extension	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	ribonuclease	ribonuclease	NOUN	NN	Number=Sing	_	_	_	_
5	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
6	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
7	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
10	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	start	start	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12199
# text = We transfected promoter-luciferase reporter plasmids into THP-1 cells to define sequences that mediate transcriptional control during monocyte differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	transfected	transfect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	promoter	promoter	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	luciferase	luciferase	ADJ	JJ	Degree=Pos	_	_	_	_
6	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
7	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
8	into	into	ADP	IN	_	_	_	_	_
9	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
15	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12200
# text = We found that sequences downstream from the transcriptional start site were sufficient to confer increased expression during THP-1 differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	start	start	NOUN	NN	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12201
# text = DNase I footprinting and sequence analysis revealed the existence of multiple AP2 and Sp1 binding sites in the 5'-untranslated and proximal coding regions.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
7	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
12	AP2	Ap2	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
21	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
24	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
25	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12202
# text = Document 0030012882 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012882	0030012882	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12203
# text = Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	fas	fas	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	death	death	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12204
# text = T cell receptor engagement activates transcription factors important for cytokine gene regulation.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
5	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12205
# text = Additionally, this signaling pathway also leads to activation-induced apoptosis in T lymphocytes that is dependent on FasL transcription and expression.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12206
# text = Here we demonstrate that nuclear factor kappaB (NF-kappaB), which is involved in the transcriptional regulation of many cytokine genes expressed in activated lymphocytes, also plays a role in T cell activation-induced FasL expression.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
23	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	also	also	ADV	RB	_	_	_	_	_
31	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	role	role	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12207
# text = Inhibition of NF-kappaB activity in a T cell hybridoma leads to decreased FasL expression and apoptosis upon T cell receptor stimulation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	hybridoma	hybridoma	NOUN	NN	Number=Sing	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	decreased	decrease	VERB	VB	VerbForm=Inf	_	_	_	_
15	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
19	upon	upon	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12208
# text = We identified the NF-kappaB site in the FasL promoter that contributes to such regulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12209
# text = Co-expression of p65 (Rel A) with the FasL promoter enhanced its activity, and co-expression of IkappaB dramatically inhibited the inducible promoter activity.
1	Co	co	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-expression	-expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p65	p65	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
7	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	co-expression	co-expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	dramatically	dramatically	ADV	RB	_	_	_	_	_
22	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12210
# text = In contrast, the transcription factor AP-1 is not required for activation-induced FasL promoter activity.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12211
# text = These results define a role for NF-kappaB in mediating FasL expression during T cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
12	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12212
# text = Document 0030012887 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012887	0030012887	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12213
# text = Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
10	D	would	NOUN	NN	Number=Sing	_	_	_	_
11	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12214
# text = We have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D mRNA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	peripheral	peripheral	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	constitutively	constitutively	ADV	RB	_	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
19	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	jun	jun	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	D	D	PROPN	NNP	Number=Sing	_	_	_	_
27	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12215
# text = Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
14	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
31	D	d	NOUN	NN	Number=Sing	_	_	_	_
32	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12216
# text = The three jun genes showed a similar time course in their induction by PMA, maximal mRNA levels being reached after 60 min of induction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
8	time	time	NOUN	NN	Number=Sing	_	_	_	_
9	course	course	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
20	reached	reach	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	60	60	NUM	CD	NumType=Card	_	_	_	_
23	min	min	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12217
# text = These results suggest that expression of c-jun, jun B and jun D genes might be involved in terminal granulocyte differentiation or in regulating granulocyte functionality.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	D	d	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
21	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	in	in	SCONJ	IN	_	_	_	_	_
25	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
27	functionality	functionality	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12218
# text = Document 0030012888 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012888	0030012888	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12219
# text = Oxidants, transcription factors, and intestinal inflammation.
1	Oxidants	Oxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
8	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12220
# text = It is now well appreciated that chronic gut inflammation is characterized by enhanced production of reactive metabolites of oxygen and nitrogen.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	appreciated	appreciate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
8	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
9	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	nitrogen	nitrogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12221
# text = Some of these oxidants are known to modulate the expression of a variety of genes that are involved in the immune and inflammatory responses.
1	Some	some	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12222
# text = For example, certain oxidants are known to activate the nuclear transcription factor kappa B, which regulates the expression of a variety of different adhesion molecules, cytokines, and enzymes.
1	For	for	ADP	IN	_	_	_	_	_
2	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
5	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12223
# text = Oxidants are also known to activate another transcription factor, activator protein-1.
1	Oxidants	Oxidant	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
7	another	another	DET	DT	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12224
# text = This transcription factor is composed of products from the fos and jun proto-oncogene family and is believed to be important in regulating cell growth and proliferation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	jun	jun	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	proto	proto	PART	TO	_	_	_	_	SpaceAfter=No
14	-oncogene	-oncogene	VERB	VB	VerbForm=Inf	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12225
# text = Finally, oxidants are believed to promote intestinal epithelial cell apoptosis, and the B-cell lymphoma/leukemia-2 gene product is believed to inhibit this phenomenon in an antioxidant-dependent manner.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
8	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
9	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lymphoma/leukemia	lymphoma/leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	product	product	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12226
# text = Taken together, these observations suggest that nontoxic concentrations of reactive metabolites of oxygen and nitrogen play an important role in regulating the expression of genes involved in the inflammatory response and in modulating apoptosis.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	nontoxic	nontoxic	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	nitrogen	nitrogen	NOUN	NN	Number=Sing	_	_	_	_
17	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	in	in	SCONJ	IN	_	_	_	_	_
34	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
35	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12227
# text = Document 0030012895 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012895	0030012895	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12228
# text = Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
3	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	alpha	alpha	ADP	IN	_	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
10	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12229
# text = The minimal region of the human tumor necrosis factor alpha (TNF-alpha) gene promoter necessary for its transcriptional induction by phorbol esters (PMA) in human
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
25	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 12230
# text = T and B lymphocyte cell lines has been localized between -52 and +89 nucleotides (nt) relative to the gene's transcriptional start site.
1	T	T	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	52	52	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
15	89	89	NUM	CD	NumType=Card	_	_	_	_
16	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	nt	not	PART	RB	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	relative	relative	ADV	RB	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	's	's	PART	POS	_	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	start	start	NOUN	NN	Number=Sing	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12231
# text = Comparison of these sequences to those required to mediate virus or lipopolysaccharide (LPS) induction of the gene reveal significant differences, and thus, the sequence requirements for PMA induction are distinct from those that mediate induction by virus or LPS.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
21	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
22	differences	difference	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
32	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
37	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
39	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12232
# text = Although three sites in the TNF-alpha promoter (kappa 1, kappa 2, and kappa 3) specifically bind the transcription factor NF-kappa B in lymphoid nuclear extracts, TNF-alpha mRNA induction by PMA does not correlate with NF-kappa B binding activities displayed by different T and B cell lines.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	3	3	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	specifically	specifically	ADV	RB	_	_	_	_	_
22	bind	bind	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
39	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
42	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	not	not	PART	RB	_	_	_	_	_
44	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
49	B	b	NOUN	NN	Number=Sing	_	_	_	_
50	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
51	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
52	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	by	by	ADP	IN	_	_	_	_	_
54	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
55	T	T	PROPN	NNP	Number=Sing	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
58	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
59	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12233
# text = Moreover, kappa 1-kappa 3 can each be deleted from the TNF-alpha promoter with little effect on the gene's inducibility by PMA.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	each	each	DET	DT	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	's	's	PART	POS	_	_	_	_	_
25	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12234
# text = Therefore, TNF-alpha mRNA induction by PMA, like its induction by virus and LPS, is not primarily mediated by NF-kappa B, but rather is mediated through other sequences and protein factors.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
6	mRNA	mRNA	X	GW	_	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	like	like	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	primarily	primarily	ADV	RB	_	_	_	_	_
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	rather	rather	ADV	RB	_	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	through	through	ADP	IN	_	_	_	_	_
34	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
35	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12235
# text = Surprisingly, multimers of kappa 1-kappa 3 can confer PMA inducibility on a heterologous promoter in a B (Raji), but not a T (HUT78) cell line.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	multimers	multimer	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
13	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	T	T	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	HUT78	HUT78	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12236
# text = However they are not functional on a truncated TNF-alpha promoter, indicating that promoter context and cell type specificity influence the PMA inducible function of these NF-kappa B binding sites.
1	However	however	ADV	RB	_	_	_	_	_
2	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	context	context	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
22	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12237
# text = Document 0030012906 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012906	0030012906	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12238
# text = Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12239
# text = CTCF is a transcriptional repressor of the c-myc gene.
1	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	myc	myc	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12240
# text = Although CTCF has been characterized in some detail, there is very little information about the regulation of CTCF activity.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	some	some	DET	DT	_	_	_	_	_
8	detail	detail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	there	there	PRON	EX	_	_	_	_	_
11	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	very	very	ADV	RB	_	_	_	_	_
13	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
14	information	information	NOUN	NN	Number=Sing	_	_	_	_
15	about	about	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CTCF	CTCF	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12241
# text = Therefore we investigated CTCF expression and phosphorylation during induced differentiation of human myeloid leukemia cells.
1	Therefore	therefore	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12242
# text = We found that: (i) both CTCF mRNA and protein are down-regulated during terminal differentiation in most cell lines tested; (ii) CTCF down-regulation is retarded and less pronounced than that of c-myc; (iii) CTCF protein is differentially phosphorylated and the phosphorylation profiles depend on the differentiation pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	i	i	X	LS	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	;	;	PUNCT	,	_	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	CTCF	CTCF	ADP	IN	_	_	_	_	_
30	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	retarded	retarded	ADJ	JJ	Degree=Pos	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
37	pronounced	pronounce	ADJ	JJ	Degree=Pos	_	_	_	_
38	than	than	ADP	IN	_	_	_	_	_
39	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	CTCF	Ctcf	NOUN	NN	Number=Sing	_	_	_	_
47	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
48	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	differentially	differentially	ADV	RB	_	_	_	_	_
50	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
54	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
55	depend	depend	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	on	on	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
59	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12243
# text = We concluded that CTCF expression and activity is controlled at transcriptional and post-transcriptional levels.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	concluded	conclude	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	CTCF	CTCF	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	post-transcriptional	post-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12244
# text = Document 0030012912 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012912	0030012912	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12245
# text = C/EBPbeta and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: implication for C/EBPbeta activity in eosinophil gene expression.
1	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	synergistically	synergistically	ADV	RB	_	_	_	_	_
7	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	_
12	granule	granule	NOUN	NN	Number=Sing	_	_	_	_
13	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
14	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	implication	implication	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	eosinophil	eosinophil	ADJ	JJ	Degree=Pos	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12246
# text = Eosinophil granule major basic protein (MBP) is expressed exclusively in eosinophils and basophils in hematopoietic cells.
1	Eosinophil	Eosinophil	PROPN	NNP	Number=Sing	_	_	_	_
2	granule	granule	NOUN	NN	Number=Sing	_	_	_	_
3	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
4	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	exclusively	exclusively	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12247
# text = In our previous study, we demonstrated a major positive regulatory role for GATA-1 and a negative regulatory role for GATA-2 in MBP gene transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	MBP	MBP	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12248
# text = Further analysis of the MBP promoter region identified a C/EBP (CCAAT/enhancer-binding protein) consensus binding site 6 bp upstream of the functional GATA-binding site in the MBP gene.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
25	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
29	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	_
36	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12249
# text = In the cell line HT93A, which is capable of differentiating towards both the eosinophil and neutrophil lineages in response to retinoic acid (RA), C/EBPalpha mRNA expression decreased significantly concomitant with eosinophilic and neutrophilic differentiation, whereas C/EBPbeta expression was markedly increased.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	line	line	NOUN	NN	Number=Sing	_	_	_	_
5	HT93A	HT93a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
12	towards	toward	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
18	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
23	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	C/	Cith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
29	EBPalpha	EBPalpha	PROPN	NNP	Number=Sing	_	_	_	_
30	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	significantly	significantly	ADV	RB	_	_	_	_	_
34	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	neutrophilic	neutrophilic	ADJ	JJ	Degree=Pos	_	_	_	_
39	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	whereas	whereas	SCONJ	IN	_	_	_	_	_
42	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	markedly	markedly	ADV	RB	_	_	_	_	_
46	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12250
# text = Electrophoretic mobility shift assays (EMSAs) showed that recombinant C/EBPbeta protein could bind to the potential C/EBP-binding site (bp -90 to -82) in the MBP promoter.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
11	C/EBPbeta	C/EBPbeta	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
14	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
18	C/EBP-	C/EBP-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	90	90	NUM	CD	NumType=Card	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	82	82	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	MBP	MBP	PROPN	NNP	Number=Sing	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12251
# text = Furthermore, we have demonstrated that both C/EBPbeta and GATA-1 can bind simultaneously to the C/EBP- and GATA-binding sites in the MBP promoter.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	both	both	CCONJ	CC	_	_	_	_	_
8	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
15	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	MBP	Mbp	PROPN	NNP	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12252
# text = To determine the functionality of both the C/EBP- and GATA- binding sites, we analyzed whether C/EBPbeta and GATA-1 can stimulate the MBP promoter in the C/EBPbeta and GATA-1 negative Jurkat T-cell line.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	functionality	functionality	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	EBP	Ebp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	whether	whether	SCONJ	IN	_	_	_	_	_
20	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	MBP	Mbp	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	negative	negative	NOUN	NN	Number=Sing	_	_	_	_
38	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
39	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12253
# text = Cotransfection with C/EBPbeta and GATA-1 expression vectors produced a 5-fold increase compared with cotransfection with the C/EBPbeta or GATA-1 expression vectors individually.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
10	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
28	individually	individually	ADV	RB	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12254
# text = In addition, GST pull-down experiments demonstrated a physical interaction between human GATA-1 and C/EBPbeta.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	GST	gst	AUX	MD	VerbForm=Fin	_	_	_	_
5	pull	pull	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	down	down	ADP	RP	_	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
12	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12255
# text = Expression of FOG (riend ATA), which binds to GATA-1 and acts as a cofactor for GATA-binding proteins, decreased transactivation activity of GATA-1 for the MBP promoter in a dose-dependent manner.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	FOG	FOG	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	riend	riend	PROPN	NNP	Number=Sing	_	_	_	_
6	ATA	ATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	MBP	Mbp	PROPN	NNP	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
42	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12256
# text = Our results provide the first evidence that both GATA-1 and C/EBPbeta synergistically transactivate the promoter of an eosinophil-specific granule protein gene and that FOG may act as a negative cofactor for the eosinophil lineage, unlike its positively regulatory function for the erythroid and megakaryocyte lineages.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	C/EBPbeta	C/EBPbeta	PROPN	NNP	Number=Sing	_	_	_	_
14	synergistically	synergistically	ADV	RB	_	_	_	_	_
15	transactivate	transactivate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	granule	granule	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	FOG	FOG	PRON	NN	Number=Sing	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
34	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	eosinophil	eosinophil	NOUN	NN	Number=Sing	_	_	_	_
38	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	unlike	unlike	ADP	IN	_	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	positively	positively	ADV	RB	_	_	_	_	_
43	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
44	function	function	NOUN	NN	Number=Sing	_	_	_	_
45	for	for	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	megakaryocyte	megakaryocyte	NOUN	NN	Number=Sing	_	_	_	_
50	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12257
# text = Document 0030012918 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012918	0030012918	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12258
# text = HIV-1
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12259
# text = Nef leads to inhibition or activation of T cells depending on its intracellular localization.
1	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
2	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	localization	localization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12260
# text = Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys.
1	Nef	Nef	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	primate	primate	ADJ	JJ	Degree=Pos	_	_	_	_
4	lentiviruses	lentiviruse	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	viremia	viremia	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monkeys	monkey	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12261
# text = Negative, positive, and no effects of Nef have also been reported on viral replication in cells.
1	Negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12262
# text = To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells.
1	To	to	PART	TO	_	_	_	_	_
2	reconcile	reconcile	VERB	VB	VerbForm=Inf	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	observations	observation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
10	CD8	CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Nef	Nef	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12263
# text = Two opposite phenotypes were found, which depended on the intracellular localization of Nef.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
3	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	depended	depend	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12264
# text = Expressed in the cytoplasm or on the cell surface, the chimera inhibited or activated early signaling events from the T cell antigen receptor.
1	Expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	chimera	chimera	NOUN	NN	Number=Sing	_	_	_	_
13	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	early	early	ADV	RB	Degree=Pos	_	_	_	_
17	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
18	events	event	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12265
# text = Activated Jurkat cells died by apoptosis, and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional.
1	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	died	die	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	nef	nef	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
16	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	Nefs	Nefs	NOUN	NNS	Number=Plur	_	_	_	_
18	survived	survive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	Nef	Nef	ADV	RB	_	_	_	_	_
23	nonfunctional	nonfunctional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12266
# text = These mutations paralleled those in other viral strains passaged in vitro.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
3	paralleled	parallel	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
8	strains	strains	NOUN	NNS	Number=Plur	_	_	_	_
9	passaged	passage	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12267
# text = Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation, but they also explain effects of Nef in HIV infection and progression to AIDS.
1	Not	not	ADV	RB	_	_	_	_	_
2	only	only	ADV	RB	_	_	_	_	_
3	do	do	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	positional	positional	ADJ	JJ	Degree=Pos	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Nef	Nef	ADJ	JJ	Degree=Pos	_	_	_	_
9	reconcile	reconcile	NOUN	NN	Number=Sing	_	_	_	_
10	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
11	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Nef	Nef	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
22	myristylation	myristylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
26	also	also	ADV	RB	_	_	_	_	_
27	explain	explain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	Nef	Nef	PROPN	NNP	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
33	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12268
# text = Document 0030012929 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012929	0030012929	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12269
# text = Regulation of nuclear factor-kappa B and its inhibitor
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
10	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12270
# text = I kappa B-alpha/MAD-3 in monocytes by Mycobacterium tuberculosis and during human tuberculosis.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	GW	_	_	_	_	_
3	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
4	alpha/	alphaith	X	ADD	_	_	_	_	SpaceAfter=No
5	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
12	tuberculosis	tuberculosis	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	during	during	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12271
# text = Blood monocytes from patients with active tuberculosis are activated in vivo, as evidenced by an increase in the stimulated release of proinflammatory cytokines, such as TNF-alpha, and the spontaneous expression of IL-2R. Further, monocytes from patients demonstrate an augmented susceptibility to a productive infection with HIV-1 in vitro.
1	Blood	Blood	NOUN	NN	Number=Sing	_	_	_	_
2	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	release	release	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2R.	2R.	PROPN	NNP	Number=Sing	_	_	_	_
40	Further	further	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
43	from	from	ADP	IN	_	_	_	_	_
44	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
45	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	augmented	augmented	ADJ	JJ	Degree=Pos	_	_	_	_
48	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
52	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	1	1	NUM	CD	NumType=Card	_	_	_	_
57	in	in	ADP	IN	_	_	_	_	_
58	vitro	vitro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12272
# text = Mycobacterium tuberculosis and its components are strong signals to activate monocytes to production of cytokines.
1	Mycobacterium	Mycobacterium	NOUN	NN	Number=Sing	_	_	_	_
2	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	components	component	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
8	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12273
# text = In this study we examined the basis of activation of monocytes during active tuberculosis and by M. tuberculosis.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
14	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_
18	tuberculosis	tuberculosis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12274
# text = We found a constitutive degradation of I kappa B-alpha, the major cytoplasmic inhibitor of nuclear factor kappa B (NF-kappa B), in freshly isolated PBMC and monocytes from patients with tuberculosis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	freshly	freshly	ADV	RB	_	_	_	_	_
30	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12275
# text = In contrast, I kappa B-alpha levels in PBMC and monocytes from healthy subjects or from patients with nontuberculous pulmonary conditions were intact.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
6	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
15	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	nontuberculous	nontuberculous	ADJ	JJ	Degree=Pos	_	_	_	_
21	pulmonary	pulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
22	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12276
# text = Further, by electrophoretic mobility shift assay, NF-kappa B was activated in monocytes from tuberculous patients.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
5	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
6	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
7	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	tuberculous	tuberculous	ADJ	JJ	Degree=Pos	_	_	_	_
19	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12277
# text = The expression of I kappa B-alpha gene, which is responsive to activation by NF-kappa B, was up-regulated in PBMC and monocytes from patients, but not in mononuclear cells from healthy subjects or those with nontuberculous lung diseases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	GW	_	_	_	_	_
6	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	GW	_	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	activation	activation	VERB	VB	VerbForm=Inf	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	not	not	ADV	RB	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
39	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	nontuberculous	nontuberculous	ADJ	JJ	Degree=Pos	_	_	_	_
44	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
45	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12278
# text = By contrast, the expression of other adherence-associated early genes, such as IL-8 and IL-1 beta, was not up-regulated in PBMC of tuberculous patients.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	adherence-associated	adherence-associated	ADJ	JJ	Degree=Pos	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	8	8	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	tuberculous	tuberculous	ADJ	JJ	Degree=Pos	_	_	_	_
32	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12279
# text = Further, M.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	M.	M.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12280
# text = tuberculosis and its tuberculin, purified protein derivative, induced the degradation of I kappa B-alpha and the expression of I kappa B-alpha mRNA, and purified protein derivative induced the activation of NF-kappa B in monocytes.
1	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	tuberculin	tuberculin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	alpha	alpha	ADP	IN	_	_	_	_	_
27	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12281
# text = Document 0030012933 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012933	0030012933	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12282
# text = Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	class	class	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	NUM	CD	NumType=Card	_	_	_	_
15	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
16	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
18	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-13	-13	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	divergent	divergent	NOUN	NN	Number=Sing	_	_	_	_
26	X2	x2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
28	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12283
# text = We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Clone	Clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
17	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	DP.	DP.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12284
# text = Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	criteria	criterion	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	isotype-specific	isotype-specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12285
# text = Indeed, transient transfection of HLA-DRA and DQB reporter constructs indicated that the affected factor operates via cis-elements located between -141 base pairs and the transcription initiation site.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
4	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
13	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	operates	operate	NOUN	NNS	Number=Plur	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	141	141	NUM	CD	NumType=Card	_	_	_	_
27	base	base	NOUN	NN	Number=Sing	_	_	_	_
28	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12286
# text = A series of hybrid DRA/DQB reporter constructs was generated to further map the relevant cis-elements in this system.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	series	series	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
5	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	DQB	Dqb	PROPN	NNP	Number=Sing	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	further	further	ADV	RB	_	_	_	_	_
14	map	map	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
17	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12287
# text = Insertion of oligonucleotides spanning the DQB X-box (but not the DQB-W region or the DQB Y-box) upstream of -141 in a DRA reporter plasmid rescued expression to nearly wild-type levels.
1	Insertion	Insertion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	oligonucleotides	oligonucleotides	NOUN	NNS	Number=Plur	_	_	_	_
4	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
7	X	x	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	box	box	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	DQB	DQB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	W	W	ADJ	JJ	Degree=Pos	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
21	Y-	y-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	141	141	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
31	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
32	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
33	rescued	rescue	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	nearly	nearly	ADV	RB	_	_	_	_	_
37	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	type	type	NOUN	NN	Number=Sing	_	_	_	_
40	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12288
# text = Substitution promoters were then generated where the entire X-box, or only the X1- or X2-boxes of HLA-DRA were replaced with the analogous regions of HLA-DQB.
1	Substitution	Substitution	NOUN	NN	Number=Sing	_	_	_	_
2	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	where	where	ADV	WRB	PronType=Int	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
9	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	X1	X1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	boxes	boxe	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
31	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12289
# text = The DQB X2-box was able to restore expression to the silent DRA reporter construct.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DQB	DQB	NOUN	NN	Number=Sing	_	_	_	_
3	X2	x2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	box	box	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
14	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12290
# text = Moreover, replacement of the DQB X2-box with the DRA X2-box markedly diminished the activity of the DQB promoter in the mutant cell.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	replacement	replacement	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
7	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	box	box	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
13	X2	X2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	box	box	NOUN	NN	Number=Sing	_	_	_	_
16	markedly	markedly	ADV	RB	_	_	_	_	_
17	diminished	diminish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12291
# text = None of the hybrid reporter constructs were defective when transfected into the wild-type, HLA-DR/-DQ positive parental cell line, Jijoye.
1	None	none	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hybrid	hybrid	ADJ	JJ	Degree=Pos	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DR/-	Dr/-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
21	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
22	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Jijoye	Jijoye	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12292
# text = These studies suggest that the divergent X2-box of the class II major histocompatibility complex promoters plays an important role in influencing differential expression of the human class II isotypes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
7	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	box	box	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
18	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
24	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	class	class	NOUN	NN	Number=Sing	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	isotypes	isotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12293
# text = Document 0030012934 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012934	0030012934	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12294
# text = Multiple transcription factors are required for activation of human interleukin 9 gene in T cells.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	9	9	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12295
# text = The genetic elements and regulatory mechanisms responsible for human interleukin 9 (IL-9) gene expression in a human T cell leukemia virus type I-transformed human T cell line, C5MJ2, were investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	9	9	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
26	type	type	NOUN	NN	Number=Sing	_	_	_	_
27	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
28	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
29	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	C5MJ2	C5mj2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12296
# text = We demonstrated that IL-9 gene expression is controlled, at least in part, by transcriptional activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	9	9	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12297
# text = Transient expression of the luciferase reporter gene linked to serially deleted sequences of the 5'-flanking region of the IL-9 gene has revealed several positive and negative regulatory elements involved in the basal and inducible expression of the IL-9 gene in C5MJ2 cells.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	luciferase	luciferase	ADJ	JJ	Degree=Pos	_	_	_	_
6	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	serially	serially	ADV	RB	_	_	_	_	_
11	deleted	delete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
19	region	region	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	9	9	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
29	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
34	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	9	9	NUM	CD	NumType=Card	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	C5MJ2	C5MJ2	NUM	CD	NumType=Card	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12298
# text = An AP-1 site at -146 to -140 was shown to be involved in the expression of the IL-9 gene.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	146	146	NUM	CD	NumType=Card	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	140	140	NUM	CD	NumType=Card	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	9	9	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12299
# text = A proximal region between -46 and -80 was identified as the minimum sequence for the basal and inducible expression of the IL-9 gene in C5MJ2 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	-46	-46	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	80	80	NUM	CD	NumType=Card	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	minimum	minimum	ADJ	JJ	Degree=Pos	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	9	9	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	C5MJ2	C5MJ2	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12300
# text = Within this region, an NF-kappaB site at -59 to -50 and its adjacent 20-base pair upstream sequence were demonstrated to play a critical role for the IL-9 promoter activity.
1	Within	within	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	59	59	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	50	50	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
19	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	base	base	NOUN	NN	Number=Sing	_	_	_	_
22	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
23	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	9	9	NUM	CD	NumType=Card	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12301
# text = DNA-protein binding studies indicated that NF-kappaB, c-Jun, and potentially novel proteins (around 35 kDa) can bind to this important sequence.
1	DNA-	DNA-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	potentially	potentially	ADV	RB	_	_	_	_	_
17	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	around	around	ADV	RB	_	_	_	_	_
21	35	35	NUM	CD	NumType=Card	_	_	_	_
22	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12302
# text = Mutations at different sites within this proximal promoter region abolished the promoter activity as well as the DNA binding.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12303
# text = Taken together, these results suggest that the cooperation of different transcription factors is essential for IL-9 gene expression in T cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	9	9	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12304
# text = Document 0030012935 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012935	0030012935	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12305
# text = AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter.
1	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CB	Cb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	Falpha2	falpha2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	PAX5	PAX5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	BLK	Blk	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12306
# text = AML1 plays a critical role during hematopoiesis and chromosomal translocations involving AML1 are commonly associated with different forms of leukemia, including pre-B acute lymphoblastic leukemia.
1	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
2	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	chromosomal	chromosomal	NOUN	NN	Number=Sing	_	_	_	_
10	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
11	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
12	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	commonly	commonly	ADV	RB	_	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
24	-B	-b	X	GW	_	_	_	_	_
25	acute	acute	X	ADD	_	_	_	_	_
26	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
27	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12307
# text = To understand the function of AML1 during B cell differentiation, we analyzed regulatory regions of B cell-specific genes for potential AML1-binding sites and have identified a putative AML1-binding site in the promoter of the B cell-specific tyrosine kinase gene, blk.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
24	AML1	Aml1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
33	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	B	b	PROPN	NNP	Number=Sing	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
46	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
47	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	blk	blk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12308
# text = Gel mobility shift assays and transient transfection assays demonstrate that AML1 binds specifically to this site in the blk promoter and this binding site is important for blk promoter activity.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
7	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
8	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	AML1	AML1	NUM	CD	NumType=Card	_	_	_	_
12	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	blk	blk	NOUN	NN	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	blk	blk	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12309
# text = Furthermore, in vitro binding analysis revealed that the AML1 runt DNA-binding domain physically interacts with the paired DNA-binding domain of BSAP, a B cell-specific transcription factor.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
7	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
11	runt	runt	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	physically	physically	ADV	RB	_	_	_	_	_
17	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	paired	paire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12310
# text = BSAP has been shown previously to be important for B cell-specific regulation of the blk gene.
1	BSAP	Bsap	SYM	NFP	_	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	blk	blk	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12311
# text = Physical interaction of AML1 with BSAP correlates with functional cooperativity in transfection studies where AML1 and BSAP synergistically activate blk promoter transcription by more than 50-fold.
1	Physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	_
7	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	cooperativity	cooperativity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
13	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
14	where	where	ADV	WRB	PronType=Rel	_	_	_	_
15	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	BSAP	Bsap	PROPN	NNP	Number=Sing	_	_	_	_
18	synergistically	synergistically	ADV	RB	_	_	_	_	_
19	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
20	blk	blk	NOUN	NN	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12312
# text = These results demonstrate physical and functional interactions between AML1 and BSAP and suggest that AML1 is an important factor for regulating a critical B cell-specific gene, blk.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	BSAP	Bsap	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	blk	blk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12313
# text = Document 0030012937 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012937	0030012937	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12314
# text = A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	shortened	shortened	ADJ	JJ	Degree=Pos	_	_	_	_
3	life	life	NOUN	NN	Number=Sing	_	_	_	_
4	span	span	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-/-	-/-	PUNCT	.	_	_	_	_	_
8	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
9	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	due	due	ADP	IN	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
19	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	ameliorated	ameliorate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
28	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12315
# text = Using homologous recombination, both EKLF alleles in murine embryonic stem (ES) cells were inactivated.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
3	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	both	both	CCONJ	CC	_	_	_	_	_
6	EKLF	Eklf	NOUN	NN	Number=Sing	_	_	_	_
7	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
10	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
11	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	ES	E	INTJ	UH	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	inactivated	inactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12316
# text = These EKLF-/- ES cells were capable of undergoing in vitro differentiation to form definitive erythroid colonies that were similar in size and number to those formed by wild-type ES cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	EKLF	EKLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-/-	-/-	PUNCT	.	_	_	_	_	_
4	ES	ES	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
8	of	of	SCONJ	IN	_	_	_	_	_
9	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
15	definitive	definitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	size	size	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	number	number	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
27	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	type	type	NOUN	NN	Number=Sing	_	_	_	_
32	ES	e	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12317
# text = However, the EKLF-/- colonies were poorly hemoglobinized and enucleated erythrocytes in these colonies contained numerous Heinz bodies.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	EKLF	Eklf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-/-	-/-	PUNCT	.	_	_	_	_	_
6	colonies	coloney	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	poorly	poorly	ADV	RB	_	_	_	_	_
9	hemoglobinized	hemoglobinize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	enucleated	enucleate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
16	contained	containe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
18	Heinz	Heinz	NOUN	NN	Number=Sing	_	_	_	_
19	bodies	body	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12318
# text = Reverse transcriptase-polymerase chain reaction (RT-PCR) analyses revealed that adult and embryonic globin genes were appropriately regulated, with the exception of beta h1-globin, which continued to be expressed at a very low level.
1	Reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
2	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
5	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
6	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	RT-PCR	Rt-pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	appropriately	appropriately	ADV	RB	_	_	_	_	_
20	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
27	h1	h1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-globin	-globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	continued	continue	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	very	very	ADV	RB	_	_	_	_	_
38	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
39	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12319
# text = The ratio of adult beta-globin/alpha-globin mRNA in the mutant ES cells was 1/15 of that in wild-type ES cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-globin/	-globin/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	alpha-globin	alpha-globin	ADJ	JJ	Degree=Pos	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
12	ES	ES	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	1/15	1/15	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	ES	ES	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12320
# text = When the EKLF-/- cells were injected into blastocysts, they did not contribute at a detectable level to the mature erythrocyte compartment of the chimeric animals, based on analysis of glucose phosphate isomerase-1 (GPI-1) isozymes and hemoglobins that distinguish ES cell-derived erythrocytes from host blastocyst-derived erythrocytes.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	EKLF	EKLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-/-	-/-	PUNCT	.	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	injected	inject	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	into	into	ADP	IN	_	_	_	_	_
9	blastocysts	blastocyst	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
18	level	level	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
22	erythrocyte	erythrocyte	NOUN	NN	Number=Sing	_	_	_	_
23	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
27	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	glucose	glucose	NOUN	NN	Number=Sing	_	_	_	_
34	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
35	isomerase	isomerase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	GPI	GPI	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	isozymes	isozyme	NOUN	NNS	Number=Plur	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	hemoglobins	hemoglobin	NOUN	NNS	Number=Plur	_	_	_	_
46	that	that	PRON	WDT	PronType=Rel	_	_	_	_
47	distinguish	distinguish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	ES	ES	ADV	RB	_	_	_	_	_
49	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
53	from	from	ADP	IN	_	_	_	_	_
54	host	host	NOUN	NN	Number=Sing	_	_	_	_
55	blastocyst	blastocyst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12321
# text = In contrast, semiquantitative RT-PCR analysis of RNA from reticulocytes of the same chimeric animals suggested that the ES cell-derived reticulocytes were present at a level of 6% to 8%.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
5	RT	Rt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	reticulocytes	reticulocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
17	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
18	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ES	ES	PROPN	NNPS	Number=Plur	_	_	_	_
22	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	reticulocytes	reticulocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	level	level	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	8%	8%	X	XX	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12322
# text = This indicated that the EKLF-/- erythrocytes in adult animals must be short-lived, apparently due to the imbalance of beta- versus alpha-globin chains, leading to the precipitation of excess alpha-globin chains to form Heinz bodies.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	EKLF	EKLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	/-	/-	PUNCT	.	_	_	_	_	_
8	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
11	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
12	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-lived	-live	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	apparently	apparently	ADV	RB	_	_	_	_	_
18	due	due	ADP	IN	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	_
25	versus	versus	CCONJ	CC	_	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
29	chains	chains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	precipitation	precipitation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	excess	excess	NOUN	NN	Number=Sing	_	_	_	_
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
40	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
43	Heinz	Heinz	PROPN	NNP	Number=Sing	_	_	_	_
44	bodies	body	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12323
# text = Consistent with this hypothesis, the short life span was ameliorated by introduction into the EKLF-/- ES cells of a human LCR/gamma-globin gene, as evidenced by the presence of ES cell-derived reticulocytes as well as mature erythrocytes in the blood of the chimeric animals.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
8	life	life	NOUN	NN	Number=Sing	_	_	_	_
9	span	span	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	ameliorated	ameliorate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
14	into	into	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	EKLF	Eklf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-/-	-/-	PUNCT	.	_	_	_	_	_
18	ES	E	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	LCR/	Lcr/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	ES	ES	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	reticulocytes	reticulocyte	NOUN	NNS	Number=Plur	_	_	_	_
40	as	as	ADV	RB	_	_	_	_	_
41	well	well	ADV	RB	Degree=Pos	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
44	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
51	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12324
# text = Document 0030012942 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012942	0030012942	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12325
# text = Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	phosphorylations	phosphorylation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12326
# text = The activation of nuclear factor kappa B (NF-kappa B) in intact cells is mechanistically not well understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	mechanistically	mechanistically	ADV	RB	_	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	well	well	ADV	RB	Degree=Pos	_	_	_	_
21	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12327
# text = Therefore we investigated the modifications imposed on NF-kappa B/I kappa B components following stimulation and show that the final step of NF-kappa B induction in vivo involves phosphorylation of several members of the NF-kappa B/I kappa B protein families.
1	Therefore	therefore	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
6	imposed	impose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B/	Bith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	components	component	NOUN	NNS	Number=Plur	_	_	_	_
16	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	final	final	ADJ	JJ	Degree=Pos	_	_	_	_
23	step	step	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
32	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
33	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
36	members	member	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	B/	B/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
44	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
45	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
46	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
47	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12328
# text = In HeLa cells as well as in B cells, TNF-alpha rapidly induced nuclear translocation primarily of p50-p65, but not of c-rel.
1	In	in	ADP	IN	_	_	_	_	_
2	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
14	rapidly	rapidly	ADV	RB	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	primarily	primarily	ADV	RB	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12329
# text = Both NF-kappa B precursors and I kappa B alpha became strongly phosphorylated with the same kinetics.
1	Both	both	DET	DT	_	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
12	became	become	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	strongly	strongly	ADV	RB	_	_	_	_	_
14	phosphorylated	phosphorylate	ADJ	JJ	Degree=Pos	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
18	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12330
# text = In addition to the inducible phosphorylation after stimulation, B lymphocytes containing constitutive nuclear NF-kappa B revealed constitutively phosphorylated p65 and I kappa B alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	after	after	ADP	IN	_	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	constitutively	constitutively	ADV	RB	_	_	_	_	_
21	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	p65	p65	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12331
# text = Phosphorylation was accompanied by induced processing of the precursors p100 and p105 and by degradation of I kappa B alpha.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
10	p100	p100	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12332
# text = As an in vitro model we show that phosphorylation of p105 impedes its ability to interact with NF-kappa B, as has been shown before for I kappa B alpha.
1	As	as	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
12	impedes	impede	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	before	before	ADP	IN	_	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12333
# text = Surprisingly, even p65, but not c-rel, was phosphorylated after induction in vivo, suggesting that TNF-alpha selectively activates only specific NF-kappa B heteromers and that modifications regulate not only I kappa B molecules but also NF-kappa B molecules.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	even	even	ADV	RB	_	_	_	_	_
4	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
23	selectively	selectively	ADV	RB	_	_	_	_	_
24	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	only	only	ADV	RB	_	_	_	_	_
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	heteromers	heteromer	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
35	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	not	not	ADV	RB	_	_	_	_	_
37	only	only	ADV	RB	_	_	_	_	_
38	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
39	kappa	kappa	X	GW	_	_	_	_	_
40	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
41	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
42	but	but	CCONJ	CC	_	_	_	_	_
43	also	also	ADV	RB	_	_	_	_	_
44	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
47	B	b	NOUN	NN	Number=Sing	_	_	_	_
48	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12334
# text = In fact, cellular NF-kappa B activity was phosphorylation-dependent and the DNA binding activity of p65-containing NF-kappa B was enhanced by phosphorylation in vitro.
1	In	in	ADP	IN	_	_	_	_	_
2	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12335
# text = Furthermore, we found that the induction by hydrogen peroxide of NF-kappa B translocation to the nucleus, which is assumed to be triggered by reactive oxygen intermediates, also coincided with incorporation of phosphate into the same subunits that were modified after stimulation by TNF-alpha.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
10	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	assumed	assume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
29	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
30	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	coincided	coincide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
38	into	into	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
41	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
42	that	that	PRON	WDT	PronType=Rel	_	_	_	_
43	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	after	after	ADP	IN	_	_	_	_	_
46	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12336
# text = Thus, phosphorylation appears to be a general mechanism for activation of NF-kappa B in vivo.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12337
# text = Document 0030012944 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012944	0030012944	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12338
# text = Identification of transcriptional suppressor proteins that bind to the negative regulatory element of the human immunodeficiency virus type 1.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12339
# text = Two different proteins which independently bound to neighboring sequences within the negative regulatory element (NRE) of human immunodeficiency virus type 1 (HIV-1) were detected in the nuclear extract of a virus-infected human T cell line.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	independently	independently	ADV	RB	_	_	_	_	_
6	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	SCONJ	IN	_	_	_	_	_
8	neighboring	neighbore	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NRE	NRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
34	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	T	t	PROPN	NNP	Number=Sing	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12340
# text = One of the factors bound to a novel dyad symmetrical sequence.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	dyad	dyad	NOUN	NN	Number=Sing	_	_	_	_
10	symmetrical	symmetrical	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12341
# text = This sequence is well conserved in various HIV-1 isolates and partial homology was found with the promoter region of the human retinoblastoma gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	isolates	isolate	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
14	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12342
# text = Similar DNA binding activity was detected in a variety of virus-uninfected human T cell lines and HeLa cells by means of a gel mobility shift assay.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	uninfected	uninfect	ADJ	JJ	Degree=Pos	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	means	means	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12343
# text = The other factor bound to a putative AP-1 recognition sequence predicted for the HIV-1 NRE.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
8	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	NRE	Nre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12344
# text = However, this factor did not bind to a typical AP-1 site.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12345
# text = The insertion of multiple copies of the binding site for the former or latter factor into a heterologous promoter reduced the promoter activity to one-tenth or one-third, respectively.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	former	former	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	into	into	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	tenth	tenth	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	third	third	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12346
# text = Thus, each factor may function as a novel negative regulator of transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	each	each	DET	DT	_	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12347
# text = Document 0030012951 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012951	0030012951	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12348
# text = Transcription factors of T and B lymphocytes--basic research and clinical perspectives for gastroenterology.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	--	--	PUNCT	,	_	_	_	_	SpaceAfter=No
9	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
10	research	research	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
13	perspectives	perspective	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	gastroenterology	gastroenterology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12349
# text = Tissue specific regulation of gene expression by transcription factors is a fascinating new field in molecular immunology.
1	Tissue	Tissue	ADP	IN	_	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	fascinating	fascinating	ADJ	JJ	Degree=Pos	_	_	_	_
13	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
14	field	field	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunology	immunology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12350
# text = This review summarizes data on specific regulation of promoters and enhancers by nuclear trans-acting factors in lymphocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	review	review	NOUN	NN	Number=Sing	_	_	_	_
3	summarizes	summarize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12351
# text = The structural classes of transcription factors are described and basic methods for detection and analysis of transcription factors are detailed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
3	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
11	methods	method	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	detailed	detaile	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12352
# text = Furthermore, the most important trans-acting factors of T and B lymphocytes (e.g. NF-kB, NF-AT and STAT families) and their functional importance are described.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	most	most	ADV	RBS	_	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	e.g.	e.g.	X	FW	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
26	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
31	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12353
# text = Several methods for specific down-regulation of transcription factors are shown that may be relevant to treatment of human disease.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	methods	method	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12354
# text = The data are discussed with regard to their potential clinical relevance for gastroenterology.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	regard	regard	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
10	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
11	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	gastroenterology	gastroenterology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12355
# text = Document 0030012957 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012957	0030012957	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12356
# text = E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha.
1	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	_
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12357
# text = Retinoic acid (RA)-induced maturation mediated by the retinoic acid receptor alpha (RAR alpha) has been implicated in myeloid development.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
25	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12358
# text = We have used differential hybridization analysis of a cDNA library constructed from the murine RA-inducible MPRO promyelocyte cell line to identify immediate-early genes induced by RA during granulocytic differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
5	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
6	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
10	library	library	NOUN	NN	Number=Sing	_	_	_	_
11	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
15	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
18	MPRO	Mpro	NOUN	NN	Number=Sing	_	_	_	_
19	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
24	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
31	during	during	ADP	IN	_	_	_	_	_
32	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12359
# text = E3, one of nine sequences identified, was upregulated in an immediate-early manner, with transcript levels peaking after 60 minutes exposure to RA.
1	E3	E3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nine	nine	NUM	CD	NumType=Card	_	_	_	_
6	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
7	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-early	-early	ADJ	JJ	Degree=Pos	_	_	_	_
15	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	60	60	NUM	CD	NumType=Card	_	_	_	_
23	minutes	minute	NOUN	NNS	Number=Plur	_	_	_	_
24	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	RA.	RA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12360
# text = E3 transcripts were RA-inducible in HL60 cells, but not in an RA-resistant subclone, HL60R, that harbors a mutated RAR alpha gene.
1	E3	E3	NUM	CD	NumType=Card	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	RA	RA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
18	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	HL60R	Hl60r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	harbors	harbor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	ADP	IN	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12361
# text = However, when HL60R cells were transduced with a functional copy of the RAR alpha gene, RA induced a 10-fold increase in E3 mRNA levels.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	HL60R	Hl60r	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	ADP	IN	_	_	_	_	_
16	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
24	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	E3	E3	NUM	CD	NumType=Card	_	_	_	_
27	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12362
# text = E3 transcripts are present in the myeloid, B-lymphoid, and erythroid lineages, absent in nonhematopoietic cells, and encode a highly hydrophobic, potentially phosphorylated polypeptide of unknown function with significant homology to a putative protein expressed in myeloid cells.
1	E3	E3	NUM	CD	NumType=Card	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	absent	absent	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	nonhematopoietic	nonhematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	encode	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	highly	highly	ADV	RB	_	_	_	_	_
26	hydrophobic	hydrophobic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	potentially	potentially	ADV	RB	_	_	_	_	_
29	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
33	function	function	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
36	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12363
# text = The murine E3 promoter harbors a single bipartite retinoic acid response element which in transient transfection assays conferred RA sensitivity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	E3	E3	NUM	CD	NumType=Card	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	harbors	harbor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
8	bipartite	bipartite	NOUN	NN	Number=Sing	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	conferred	confer	ADJ	JJ	Degree=Pos	_	_	_	_
19	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
20	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12364
# text = These results indicate that E3 is a hematopoietic-specific gene that is an immediate target for the activated RAR alpha during myelopoiesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	E3	E3	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
16	target	target	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	myelopoiesis	myelopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12365
# text = Document 0030012963 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012963	0030012963	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12366
# text = Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha.
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
13	alone	alone	ADV	RB	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	soluble	soluble	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-bound	-bound	ADP	IN	_	_	_	_	_
22	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12367
# text = The level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogenesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
5	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	individual	individual	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12368
# text = Among host immune factors, the cytokine TNF-alpha has previously been shown to increase HIV-1 replication in various monocyte and T cell model systems.
1	Among	among	ADV	RB	Degree=Pos	_	_	_	_
2	host	host	ADV	RBS	_	_	_	_	_
3	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	previously	previously	ADV	RB	_	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
17	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
27	model	model	NOUN	NN	Number=Sing	_	_	_	_
28	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12369
# text = Here, we demonstrate that signaling through the TNF receptor family member, the lymphotoxin-beta (LT-beta) receptor (LT-betaR), also regulates HIV-1 replication.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	lymphotoxin-	lymphotoxin-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	betaR	betaR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	also	also	ADV	RB	_	_	_	_	_
30	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12370
# text = Furthermore, HIV-1 replication is cooperatively stimulated when the distinct LT-betaR and TNF receptor systems are simultaneously engaged by their specific ligands.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cooperatively	cooperatively	ADV	RB	_	_	_	_	_
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	betaR	betaR	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	TNF	TNF	SCONJ	IN	_	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	simultaneously	simultaneously	ADV	RB	_	_	_	_	_
22	engaged	engage	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12371
# text = Moreover, in a physiological coculture cellular assay system, we show that membrane-bound TNF-alpha and LT-alpha1beta2 act virtually identically to their soluble forms in the regulation of HIV-1 replication.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	coculture	coculture	NOUN	NN	Number=Sing	_	_	_	_
7	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
8	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
9	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	LT-alpha1	LT-alpha1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
23	act	act	NOUN	NN	Number=Sing	_	_	_	_
24	virtually	virtually	ADV	RB	_	_	_	_	_
25	identically	identically	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
29	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12372
# text = Thus, cosignaling via the LT-beta and TNF-alpha receptors is probably involved in the modulation of HIV-1 replication and the subsequent determination of HIV-1 viral burden in monocytes.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cosignaling	cosignal	VERB	VBG	VerbForm=Ger	_	_	_	_
4	via	via	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	LT-	Lt-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	probably	probably	ADV	RB	_	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
27	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
33	burden	burden	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12373
# text = Intriguingly, surface expression of LT-alpha1beta2 is up-regulated on a T cell line acutely infected with HIV-1, suggesting a positive feedback loop between HIV-1 infection, LT-alpha1beta2 expression, and HIV-1 replication.
1	Intriguingly	Intriguingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	surface	surface	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	LT-	Lt-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	alpha1	alpha1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	acutely	acutely	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
28	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
29	loop	loop	NOUN	NN	Number=Sing	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	LT-	LT-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	alpha1	alpha1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	beta2	beta2	NUM	CD	NumType=Card	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12374
# text = Given the critical role that LT-alpha1beta2 plays in lymphoid architecture, we speculate that LT-alpha1beta2 may be involved in HIV-associated abnormalities of the lymphoid organs.
1	Given	give	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	LT-alpha1	LT-alpha1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	beta2	beta2	PART	TO	Abbr=Yes	_	_	_	_
8	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	architecture	architecture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	LT-alpha1	LT-alpha1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	beta2	beta2	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
28	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12375
# text = Document 0030012967 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012967	0030012967	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12376
# text = Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.
1	Calcium/calmodulin	Calcium/calmodulin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	downregulates	downregulate	NOUN	NNS	Number=Plur	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C-	C-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12377
# text = Engagement of the T cell receptor for antigen activates phospholipase C resulting in an increase in intracellular free calcium concentration ([Ca2+]i) and activation of protein kinase C (PKC).
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
10	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
11	C	class	PROPN	NNP	Number=Sing	_	_	_	_
12	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
25	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12378
# text = Increased [Ca2+]i activates Ca2+/calmodulin-dependent kinases including the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaM-K II), as well as calcineurin, a type 2B protein phosphatase.
1	Increased	increase	PROPN	NNP	Number=Sing	_	_	_	_
2	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
5	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	Ca2+/calmodulin	Ca2+/calmodulin	ADP	IN	_	_	_	_	SpaceAfter=No
9	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	multifunctional	multifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
14	Ca2+/calmodulin	Ca2+/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	K	k	NUM	CD	NumType=Card	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	as	as	ADV	RB	_	_	_	_	_
28	well	well	ADV	RB	Degree=Pos	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	calcineurin	calcineurin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	type	type	NOUN	NN	Number=Sing	_	_	_	_
34	2B	2b	NOUN	NN	Number=Sing	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12379
# text = Recent studies have identified calcineurin as a key enzyme for interleukin (IL)-2 and IL-4 promoter activation.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
9	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12380
# text = However, the role of CaM-K II remains unknown.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	K	K	PROPN	NNP	Number=Sing	_	_	_	_
9	II	II	PROPN	NNP	Number=Sing	_	_	_	_
10	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12381
# text = We have used mutants of these kinases and phosphatases (gamma B*CaM-K and delta CaM-AI, respectively) to explore their relative role in cytokine gene transcription and their interactions with PKC-dependent signaling systems.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
14	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	K	K	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
19	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AI	ai	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
27	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
41	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
42	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12382
# text = gamma B*CaM-K and delta CaM-AI, known to exhibit constitutive Ca(2+)-independent activity, were cotransfected (alone or in combination) in Jurkat T cells with a plasmid containing the intact IL-2 promoter driving the expression of the chloramphenicol acetyltransferase reporter gene.
1	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
2	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
4	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	K	K	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
9	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	AI	ai	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	exhibit	exhibit	NOUN	NN	Number=Sing	_	_	_	_
16	constitutive	constitutive	NOUN	NN	Number=Sing	_	_	_	_
17	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
35	T	t	PROPN	NNP	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
40	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
43	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
47	driving	drive	VERB	VBG	VerbForm=Ger	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
53	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
54	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
55	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12383
# text = Cotransfection of gamma B*CaM-K with the IL-2 promoter construct downregulated its transcription in response to stimulation with ionomycin and phorbol myristate acetate (PMA).
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
6	CaM	CaM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	K	K	NUM	CD	NumType=Card	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
16	downregulated	downregulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
27	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
28	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12384
# text = The inhibitory effect of CaM-K II on IL-2 promoter was associated with decreased transcription of its AP-1 and NF-AT transactivating pathways.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	K	K	NUM	CD	NumType=Card	_	_	_	_
8	II	II	NUM	CD	NumType=Card	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	AT	at	SCONJ	IN	_	_	_	_	_
28	transactivating	transactivating	VERB	VBG	VerbForm=Ger	_	_	_	_
29	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12385
# text = Under the same conditions, delta CaM-AI superinduced IL-2 promoter activity (approximately twofold increase).
1	Under	under	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
4	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
7	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AI	be	PROPN	NNP	Number=Sing	_	_	_	_
10	superinduced	superinduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	twofold	twofold	ADJ	JJ	Degree=Pos	_	_	_	_
19	increase	increase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12386
# text = When both mutants were used in combination, gamma B*CaM-K inhibited the induction of the IL-2 promoter by delta CaM-AI.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
12	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	K	K	NUM	CD	NumType=Card	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
26	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	AI	ai	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12387
# text = Similar results were obtained when a construct containing the IL-4 promoter also was used.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12388
# text = gamma B*CaM-K also downregulated the activation of AP-1 in response to transfection with a constitutively active mutant of PKC or stimulation with PMA.
1	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
2	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	*	*	PUNCT	NFP	_	_	_	_	SpaceAfter=No
4	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	K	K	PROPN	NNP	Number=Sing	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	downregulated	downregulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	transfection	transfection	VERB	VB	VerbForm=Inf	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	constitutively	constitutively	ADV	RB	_	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12389
# text = These results suggest that CaM-K II may exert negative influences on cytokine gene transcription in human T cells, and provide preliminary evidence for negative cross-talk with the calcineurin- and PKC- dependent signaling systems.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	K	K	NUM	CD	NumType=Card	_	_	_	_
8	II	II	NUM	CD	NumType=Card	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	influences	influence	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
24	preliminary	preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
25	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	cross-talk	cross-talk	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	_
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
38	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12390
# text = Document 0030012969 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012969	0030012969	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12391
# text = HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28.
1	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
2	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CD3/CD28	CD3/CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12392
# text = In this report, we demonstrate that the T cell tropic strain of HIV, LAI, does not replicate in naive CD4 T cells stimulated by cross-linking CD3 and CD28.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	tropic	tropic	ADJ	JJ	Degree=Pos	_	_	_	_
12	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	SCONJ	IN	_	_	_	_	_
28	cross-linking	cross-link	VERB	VBG	VerbForm=Ger	_	_	_	_
29	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12393
# text = In contrast, LAI replicates well in memory CD4 T cells stimulated in the same way.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LAI	LAI	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	replicates	replicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	well	well	ADV	RB	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
9	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	way	way	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12394
# text = Unlike this physiologically relevant stimulation, PHA stimulates productive LAI replication in both naive and memory T cells.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	physiologically	physiologically	ADV	RB	_	_	_	_	_
4	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
8	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
10	LAI	Lai	NOUN	NN	Number=Sing	_	_	_	_
11	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	memory	memory	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12395
# text = These studies were conducted with highly purified (FACS-isolated) subsets of CD4 T cells identified by expression of both CD45RA and CD62L.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	conducted	conduct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	FACS	Fac	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	CD45RA	CD45RA	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	CD62L	CD62L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12396
# text = Remixing of purified T cells showed that naive T cells do not suppress LAI replication in memory T cells and that memory T cells do not restore LAI expression in naive T cells.
1	Remixing	Remixing	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	T	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
14	LAI	Lai	ADJ	JJ	Degree=Pos	_	_	_	_
15	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
28	LAI	Lai	PROPN	NNP	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12397
# text = The suppression of productive LAI replication in naive T cells is not due to differential expression of viral coreceptors, nor is it due to inhibition of activation of the important HIV transcription factors, nuclear factor-kappaB and activator protein-1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
5	LAI	LAI	PROPN	NNP	Number=Sing	_	_	_	_
6	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	due	due	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	coreceptors	coreceptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	nor	nor	CCONJ	CC	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	due	due	ADP	IN	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12398
# text = The inherent resistance of naive T cells to productive HIV infection, coupled with their proliferative advantage as demonstrated here, provides a sound basis for proposed clinical therapies using ex vivo expansion and reinfusion of CD4 T cells from HIV-infected adults.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inherent	inherent	ADJ	JJ	Degree=Pos	_	_	_	_
3	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	productive	productive	VERB	VB	VerbForm=Inf	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
17	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	sound	sound	NOUN	NN	Number=Sing	_	_	_	_
25	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
29	therapies	therapy	NOUN	NNS	Number=Plur	_	_	_	_
30	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
31	ex	ex	ADJ	JJ	Degree=Pos	_	_	_	_
32	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
33	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	reinfusion	reinfusion	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12399
# text = Document 0030012972 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012972	0030012972	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12400
# text = Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12401
# text = Critical role for IL-6.
1	Critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12402
# text = The T cell activation is initiated by interaction of specific Ags with TCR, followed by activation of intracellular biochemical events leading to activation of several genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ags	ag	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	TCR	Tcr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
21	events	event	NOUN	NNS	Number=Plur	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12403
# text = The activation of signal transducer and activator of transcription (STAT) proteins in a primary TCR-mediated activation of T cells have been explored.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12404
# text = In purified human peripheral blood T cells, nuclear
1	In	in	ADP	IN	_	_	_	_	_
2	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 12405
# text = STAT proteins were activated approximately 3 h after activation by cross-linked anti-CD3
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	approximately	approximately	ADV	RB	_	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	h	h	NOUN	NN	Number=Sing	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	anti-CD3	anti-CD3	X	ADD	_	_	_	_	_

# sent_id = 12406
# text = Abs.
1	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12407
# text = These STAT proteins were detected by using the IFN-gamma-activated sequence (GAS) and related oligonucleotides as probes in electrophoretic mobility shift assay.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
19	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
24	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12408
# text = Analysis of the nuclear extracts with anti-STAT Abs indicated that they contained STAT-3 and additional proteins crossreactive with the STAT family.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	anti-STAT	anti-stat	ADJ	JJ	Degree=Pos	_	_	_	_
8	Abs	Abs	NOUN	NNS	Number=Plur	_	_	_	_
9	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	crossreactive	crossreactive	ADJ	JJ	Degree=Pos	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12409
# text = The induction of STAT activity was inhibited completely by pretreatment with either cycloheximide or cyclosporin A, thus indicating that the induction was due to a secondary factor produced by the activated T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
16	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	thus	thus	ADV	RB	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	due	due	ADP	IN	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12410
# text = As neutralizing anti-IL-6
1	As	as	SCONJ	IN	_	_	_	_	_
2	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_
3	anti-IL	anti-IL	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	6	6	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12411
# text = Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR-mediated bindings, it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response.
1	Abs	Ab	ADV	RB	_	_	_	_	_
2	effectively	effectively	ADV	RB	_	_	_	_	_
3	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	exogenously	exogenously	ADV	RB	_	_	_	_	_
15	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	rapidly	rapidly	ADV	RB	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	bindings	bindings	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
31	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	6	6	NUM	CD	NumType=Card	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
47	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
51	T	t	PROPN	NNP	Number=Sing	_	_	_	_
52	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
53	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12412
# text = Document 0030012974 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012974	0030012974	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12413
# text = Reversible differentiation of human monoblastic leukemia U937 cells by ML-9, an inhibitor of myosin light chain kinase.
1	Reversible	Reversible	ADJ	JJ	Degree=Pos	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	monoblastic	monoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	U937	U937	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	myosin	myosin	NOUN	NN	Number=Sing	_	_	_	_
18	light	light	NOUN	NN	Number=Sing	_	_	_	_
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12414
# text = Human monoblastic leukemia U937 cells are induced to differentiate into monocytes and macrophages by various agents.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	monoblastic	monoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	U937	U937	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
16	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12415
# text = We have shown that 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9), an inhibitor of myosin light chain kinase, induces differentiation of monocytoid leukemia cell lines U937 and THP-1 but not of myeloblastic leukemic ML-1 cell or erythroleukemia K562 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	1-(	1-(	SYM	NFP	_	_	_	_	SpaceAfter=No
6	5-chloronaphthalene	5-chloronaphthalene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-sulfonyl	-sulfonyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-1H-hexahydro	-1H-hexahydro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-1,4-diazepine	-1,4-diazepine	NOUN	NN	Number=Sing	_	_	_	_
13	hydrochloride	hydrochloride	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ML	Ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	myosin	myosin	NOUN	NN	Number=Sing	_	_	_	_
24	light	light	NOUN	NN	Number=Sing	_	_	_	_
25	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	monocytoid	monocytoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
35	U937	U937	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	not	not	PART	RB	_	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	myeloblastic	myeloblastic	ADJ	JJ	Degree=Pos	_	_	_	_
44	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
45	ML	Ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	or	or	CCONJ	CC	_	_	_	_	_
50	erythroleukemia	erythroleukemion	NOUN	NN	Number=Sing	_	_	_	_
51	K562	K562	NUM	CD	NumType=Card	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12416
# text = In the present study, we further analyzed the effect of ML-9 in comparison with that of 1 alpha, 25-dihydroxyvitamin D3 (VD3) a typical inducer of monocytic differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	further	further	ADV	RB	_	_	_	_	_
8	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	9	9	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
26	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	VD3	VD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
32	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12417
# text = ML-9 induced nitroblue tetrazolium (NBT)-reducing activity of U937 cell more rapidly than VD3:
1	ML	Ml	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	9	9	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	nitroblue	nitroblue	ADJ	JJ	Degree=Pos	_	_	_	_
6	tetrazolium	tetrazolium	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NBT	NBT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	more	more	ADV	RBR	_	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	VD3	VD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 12418
# text = This differentiation marker was induced significantly after incubation with ML-9 and VD3 for 4 hours and 1 day, respectively.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	significantly	significantly	ADV	RB	_	_	_	_	_
7	after	after	ADP	IN	_	_	_	_	_
8	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	9	9	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	day	day	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12419
# text = ML-9 also induced alpha-naphthyl acetate esterase (ANAE) activity, another monocytic differentiation marker, more rapidly than VD3.
1	ML	Ml	SYM	$	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	9	9	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	naphthyl	naphthyl	NOUN	NN	Number=Sing	_	_	_	_
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
10	esterase	esterase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ANAE	ANAE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	another	another	DET	DT	_	_	_	_	_
17	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	marker	marker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	more	more	ADV	RBR	_	_	_	_	_
22	rapidly	rapidly	ADV	RB	_	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	VD3	VD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12420
# text = The maximum levels of these markers induced by ML-9 were comparable to those induced by VD3, but after removal of ML-9 from the medium by washing the cells, the expressions of theses markers decreased within 4 hours and reached basal levels in 1 day, indicating that ML-9's induction of expression of differentiation-associated phenotypes was reversible.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	9	9	NUM	CD	NumType=Card	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	VD3	VD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	9	9	NUM	CD	NumType=Card	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	SCONJ	IN	_	_	_	_	_
31	washing	wash	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expressions	expression	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
39	s	's	PART	POS	_	_	_	_	_
40	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
41	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	within	within	ADP	IN	_	_	_	_	_
43	4	4	NUM	CD	NumType=Card	_	_	_	_
44	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
48	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	1	1	NUM	CD	NumType=Card	_	_	_	_
51	day	day	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
54	that	that	SCONJ	IN	_	_	_	_	_
55	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
57	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
58	's	's	PART	POS	_	_	_	_	_
59	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
66	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
67	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
68	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12421
# text = The growth inhibition of U937 cells by ML-9 was also reversible.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	U937	U937	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	9	9	NUM	CD	NumType=Card	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12422
# text = Similar effects were observed in another line of human monoblastic cells, THP-1. ML-9 had little or no effect on the morphology of U937 cells but increased the expression of monocyte-macrophage lineage-associated surface antigen, CD14, to some extent.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	another	another	DET	DT	_	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monoblastic	monoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_
17	ML	Ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	9	9	NUM	CD	NumType=Card	_	_	_	_
20	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	no	no	DET	DT	_	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	U937	U937	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
39	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
43	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	to	to	ADP	IN	_	_	_	_	_
48	some	some	DET	DT	_	_	_	_	_
49	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12423
# text = Irreversible terminal differentiation induced by VD3 is associated with down regulation of the expression of c-myc and upregulation of the expression of c-fos and c-jun, but ML-9 did not affect the expression of these oncogenes appreciably.
1	Irreversible	Irreversible	ADJ	JJ	Degree=Pos	_	_	_	_
2	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	VD3	VD3	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	down	down	NOUN	NN	Number=Sing	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
29	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	9	9	NUM	CD	NumType=Card	_	_	_	_
35	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
43	appreciably	appreciably	ADV	RB	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12424
# text = ML-9-induced differentiation was also reversible when the cells were cultured with cultured with ML-9 plus an anti-cancer drug such as 1-beta-D-arabino-furanosylcytosine or daunomycin.
1	ML	Ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	9	9	NUM	CD	NumType=Card	_	_	_	_
20	plus	plus	CCONJ	CC	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	anti-cancer	anti-cancer	ADJ	JJ	Degree=Pos	_	_	_	_
23	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	1-beta	1-beta	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-D-	-D-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	arabino	arabino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	furanosylcytosine	furanosylcytosine	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	daunomycin	daunomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12425
# text = it became irreversible, however, upon simultaneous treatment with dexamethasone and transforming growth factor-beta 1 (TGF-beta 1), which did not induce differentiation of U937 cells but caused growth arrest of the cells in the G0/G1 phase of the cell cycle.
1	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	became	become	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	irreversible	irreversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	upon	upon	ADP	IN	_	_	_	_	_
8	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	factor-beta	factor-beta	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	U937	U937	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
35	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	G0/G1	G0/G1	PROPN	NNP	Number=Sing	_	_	_	_
42	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12426
# text = These results suggest that ML-9 should be useful for studying the mechanisms of monocytic differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	9	9	NUM	CD	NumType=Card	_	_	_	_
8	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	SCONJ	IN	_	_	_	_	_
12	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12427
# text = Document 0030012976 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012976	0030012976	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12428
# text = GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.
1	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
6	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	xL	xl	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12429
# text = The transcription factor GATA-1 is essential for normal erythropoiesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	erythropoiesis	erythropoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12430
# text = By examining in vitro-differentiated embryonic stem cells, we showed previously that in the absence of GATA-1, committed erythroid precursors fail to complete maturation and instead undergo apoptosis.
1	By	by	SCONJ	IN	_	_	_	_	_
2	examining	examine	VERB	VBG	VerbForm=Ger	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
8	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	committed	commit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
25	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
26	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
29	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	instead	instead	ADV	RB	_	_	_	_	_
32	undergo	undergo	ADJ	JJ	Degree=Pos	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12431
# text = The mechanisms by which GATA-1 controls cell survival are unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	DET	WDT	PronType=Int	_	_	_	_
5	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12432
# text = Here we report that in erythroid cells, GATA-1 strongly induces the expression of the anti-apoptotic protein bcl-xL, but not the related proteins bcl-2 and mcl-1.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	anti-apoptotic	anti-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	xL	xl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
29	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	mcl	mcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12433
# text = Consistent with a role for bcl-xL in mediating GATA-1-induced erythroid cell survival, in vitro-differentiated bcl-xL-/- embryonic stem cells fail to generate viable mature definitive erythroid cells, a phenotype resembling that of GATA-1 gene disruption.
1	Consistent	consistent	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	xL	xl	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	differentiated	differentiated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	xL	xl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-/-	-/-	PUNCT	.	_	_	_	_	_
28	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
29	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
34	viable	viable	ADJ	JJ	Degree=Pos	_	_	_	_
35	mature	mature	NOUN	NN	Number=Sing	_	_	_	_
36	definitive	definitive	ADJ	JJ	Degree=Pos	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
42	resembling	resembl	VERB	VBG	VerbForm=Ger	_	_	_	_
43	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
49	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12434
# text = In addition, we show that erythropoietin, which is also required for erythroid cell survival, cooperates with GATA-1 to stimulate bcl-xL gene expression and to maintain erythroid cell viability during terminal maturation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
25	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	xL	xl	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
33	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	viability	viability	NOUN	NN	Number=Sing	_	_	_	_
36	during	during	ADP	IN	_	_	_	_	_
37	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
38	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12435
# text = Together, our data show that bcl-xL is essential for normal erythroid development and suggest a regulatory hierarchy in which bcl-xL is a critical downstream effector of GATA-1 and erythropoietin-mediated signals.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	xL	xl	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	hierarchy	hierarchy	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	xL	xl	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
29	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
30	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	erythropoietin-	erythropoietin-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12436
# text = Document 0030012981 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012981	0030012981	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12437
# text = Estrogen receptor diminishes DNA-binding activities of chicken GATA-1 and CACCC-binding proteins.
1	Estrogen	Estrogen	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	diminishes	diminishe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	chicken	chicken	NOUN	NN	Number=Sing	_	_	_	_
10	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	CACCC	Caccc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12438
# text = The estrogen receptor (ER) repressed erythroid differentiation and erythroid-specific gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12439
# text = In this study, we investigated the effect of ER alpha (referred to throughout as ER) on DNA-binding activities of transcription factors involved in regulating the expression of erythroid-specific genes, and, in particular, the histone
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	ER	er	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	throughout	throughout	VERB	VB	VerbForm=Inf	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
27	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	SCONJ	IN	_	_	_	_	_
29	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
36	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	histone	histone	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12440
# text = H5 gene.
1	H5	H5	NUM	CD	NumType=Card	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12441
# text = Using electrophoretic mobility shift assays, we found that in the presence of rabbit reticulocyte lysate, human ER reduced the binding activities of chicken immature erythrocyte nuclear extracted proteins to GATA and CACCC sites in the H5 promoter and enhancer.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
15	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
16	lysate	lysate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	ER	er	NOUN	NN	Number=Sing	_	_	_	_
20	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	chicken	chicken	NOUN	NN	Number=Sing	_	_	_	_
26	immature	immature	NOUN	NN	Number=Sing	_	_	_	_
27	erythrocyte	erythrocyte	NOUN	NN	Number=Sing	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	CACCC	CACCC	PROPN	NNP	Number=Sing	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	H5	H5	PROPN	NNP	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12442
# text = In contrast, the binding activities of NF1 and Sp1 were not affected by ER. Binding of ER to an estrogen response element was enhanced by addition of rabbit reticulocyte lysate.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF1	NF1	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	ER	Er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_
17	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	ER	er	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	estrogen	estrogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
31	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
32	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12443
# text = This lysate was also necessary for ER to diminish the DNA-binding activity of GATA-1.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	ER	er	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	diminish	diminish	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12444
# text = These results suggest that additional factor(s) are necessary for full ER function.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
14	ER	er	NOUN	NN	Number=Sing	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12445
# text = Both GATA-1 and CACCC-binding proteins are critical for the developmentally regulated expression of erythroid-specific genes.
1	Both	both	DET	DT	_	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	CACCC	Caccc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	developmentally	developmentally	ADV	RB	_	_	_	_	_
15	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12446
# text = We hypothesize that interference in DNA-binding activities of GATA-1 and CACCC-binding proteins is the mechanism by which the ER inhibits regulation of these genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesize	hypothesize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CACCC	Caccc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ER	er	NOUN	NN	Number=Sing	_	_	_	_
26	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
27	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12447
# text = Document 0030012984 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012984	0030012984	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12448
# text = Transcription factor requirements for U2 snRNA-encoding gene activation in B lymphoid cells.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	U2	U2	NUM	CD	NumType=Card	_	_	_	_
6	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	encoding	encod	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12449
# text = Transcription of a human U2 small nuclear RNA(snRNA)-encoding gene in HeLa cells requires a distal enhancer element, which is composed of one octamer motif (Oct) and three Sp 1-binding sites.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	U2	u2	NOUN	NN	Number=Sing	_	_	_	_
6	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	snRNA	snRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	one	one	NUM	CD	NumType=Card	_	_	_	_
29	octamer	octamer	ADJ	JJR	Degree=Cmp	_	_	_	_
30	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	three	three	NUM	CD	NumType=Card	_	_	_	_
36	Sp	sp	NOUN	NN	Number=Sing	_	_	_	_
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12450
# text = To study the transcription factor requirement in B-cells, different
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 12451
# text = U2 enhancer constructions were transfected into the lymphoid cell line, BJA-B.
1	U2	U2	NUM	CD	NumType=Card	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	constructions	construction	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	BJA	BJA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12452
# text = The results showed that the activation of U2 snRNA transcription in B-cells also requires an enhancer comprising both the Oct and at least one Sp 1-binding site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	U2	U2	NUM	CD	NumType=Card	_	_	_	_
9	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	comprising	comprise	NOUN	NN	Number=Sing	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	at	at	ADV	RB	_	_	_	_	_
24	least	least	ADV	RBS	Degree=Sup	_	_	_	_
25	one	one	NUM	CD	NumType=Card	_	_	_	_
26	Sp	sp	NOUN	NN	Number=Sing	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12453
# text = Deletion of all the Sp 1-binding sites from the enhancer reduces transcription by 80-90% in HeLa, as well as in BJA-B cells, whereas the removal of the octamer-binding site reduces transcription to levels below detection in both cell types.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	all	all	DET	PDT	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Sp	sp	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	%	%	SYM	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	as	as	ADV	RB	_	_	_	_	_
24	well	well	ADV	RB	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	BJA	BJA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	whereas	whereas	SCONJ	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	site	site	NOUN	NN	Number=Sing	_	_	_	_
41	reduces	reduce	NOUN	NNS	Number=Plur	_	_	_	_
42	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
45	below	below	ADP	IN	_	_	_	_	_
46	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	both	both	DET	DT	_	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12454
# text = Enhancers containing a single Oct have, nevertheless, the capacity to partially activate U2 snRNA transcription in both HeLa cells, in which only OTF-1 is expressed, and in BJA-B cells in which OTF-2 is the predominantly expressed octamer-binding factor.
1	Enhancers	Enhancer	NOUN	NNS	Number=Plur	_	_	_	_
2	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
5	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
6	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	partially	partially	ADV	RB	_	_	_	_	_
14	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
15	U2	U2	NUM	CD	NumType=Card	_	_	_	_
16	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	only	only	ADV	RB	_	_	_	_	_
26	OTF	Otf	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	BJA	BJA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	predominantly	predominantly	ADV	RB	_	_	_	_	_
46	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
50	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12455
# text = The most likely interpretation of our results is that both the ubiquitous transcription factor, OTF-1, and the B-cell-specific transcription factor, OTF-2, can activate U2 snRNA transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	most	most	ADV	RBS	_	_	_	_	_
3	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
4	interpretation	interpretation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	OTF	OTF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	OTF	OTF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
35	U2	U2	NUM	CD	NumType=Card	_	_	_	_
36	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12456
# text = The results also revealed a similar functional cooperation between the transcription factors which bind to the Oct and the adjacent Sp 1-binding site in BJA-B cells, as has been observed in HeLa cells, since a template which contains a weak binding site for OTFs expresses wild-type levels of U2 snRNA in both cell types when the weak octamer-binding site is combined with a Sp 1-binding site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
21	Sp	sp	NOUN	NN	Number=Sing	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	BJA	BJA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	since	since	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	template	template	NOUN	NN	Number=Sing	_	_	_	_
43	which	which	PRON	WDT	PronType=Rel	_	_	_	_
44	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
47	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
48	site	site	NOUN	NN	Number=Sing	_	_	_	_
49	for	for	ADP	IN	_	_	_	_	_
50	OTFs	Otfs	PROPN	NNP	Number=Sing	_	_	_	_
51	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
52	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	type	type	NOUN	NN	Number=Sing	_	_	_	_
55	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	U2	U2	NUM	CD	NumType=Card	_	_	_	_
58	snRNA	snRNa	NOUN	NN	Number=Sing	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	both	both	DET	DT	_	_	_	_	_
61	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
62	types	type	NOUN	NNS	Number=Plur	_	_	_	_
63	when	when	ADV	WRB	PronType=Int	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
66	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
69	site	site	NOUN	NN	Number=Sing	_	_	_	_
70	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
71	combined	combin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
72	with	with	ADP	IN	_	_	_	_	_
73	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
74	Sp	sp	NOUN	NN	Number=Sing	_	_	_	_
75	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
76	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
77	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
78	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12457
# text = Document 0030012991 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012991	0030012991	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12458
# text = Unexpected and coordinated expression of Spi-1, Fli-1, and megakaryocytic genes in four Epo-dependent cell lines established from transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen.
1	Unexpected	unexpect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	four	four	NUM	CD	NumType=Card	_	_	_	_
17	Epo-dependent	Epo-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
23	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
24	displaying	display	VERB	VBG	VerbForm=Ger	_	_	_	_
25	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	thermosensitive	thermosensitive	ADJ	JJ	Degree=Pos	_	_	_	_
32	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
33	T	T	PROPN	NNP	Number=Sing	_	_	_	_
34	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12459
# text = Most erythroleukemic cell lines established in vitro coexpress erythrocytic and megakaryocytic markers that often are associated with expression of Spi-1 and/or Fli-1 transcription factors known as transactivators of megakaryocyte-specific promoters.
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	erythroleukemic	erythroleukemic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
8	coexpress	coexpress	NOUN	NNS	Number=Plur	_	_	_	_
9	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	often	often	ADV	RB	_	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	or	or	CCONJ	CC	_	_	_	_	_
26	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	megakaryocyte	megakaryocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12460
# text = In the present study, we examined the possibility of establishing new cell lines keeping strictly erythroid-specific properties in vitro through the targeted and conditional immortalization of erythrocytic progenitors.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	establishing	establish	VERB	VBG	VerbForm=Ger	_	_	_	_
12	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	keeping	keep	VERB	VBG	VerbForm=Ger	_	_	_	_
16	strictly	strictly	ADV	RB	_	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	targeted	target	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
28	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12461
# text = For that purpose, we established several lines of transgenic mice displaying erythroid-specific expression of a thermosensitive SV40 T antigen.
1	For	for	ADP	IN	_	_	_	_	_
2	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	established	establish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
12	displaying	display	VERB	VBG	VerbForm=Ger	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	thermosensitive	thermosensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
21	T	T	PROPN	NNP	Number=Sing	_	_	_	_
22	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12462
# text = As expected, these transgenic mice developed splenomegaly due to the massive amplification of Ter 119 positive erythroid nucleated cells expressing T antigen.
1	As	as	ADP	IN	_	_	_	_	_
2	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
7	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	splenomegaly	splenomegaly	ADV	RB	_	_	_	_	_
9	due	due	ADP	IN	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	massive	massive	ADJ	JJ	Degree=Pos	_	_	_	_
13	amplification	amplification	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Ter	Ter	PROPN	NNP	Number=Sing	_	_	_	_
16	119	119	NUM	CD	NumType=Card	_	_	_	_
17	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
18	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
19	nucleated	nucleate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12463
# text = Despite this drastic effect in vivo, the in vitro immortalization of erythropoietin-dependent erythroid progenitors unexpectedly occurred at low frequency, and all four cell lines established expressed both erythrocytic (globins) and megakaryocytic markers (glycoprotein IIb, platelet factor
1	Despite	despite	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	drastic	drastic	ADJ	JJ	Degree=Pos	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vivo	vivo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
11	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
17	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
18	unexpectedly	unexpectedly	ADV	RB	_	_	_	_	_
19	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	all	all	DET	PDT	_	_	_	_	_
26	four	four	NUM	CD	NumType=Card	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	expressed	express	ADJ	JJ	Degree=Pos	_	_	_	_
31	both	both	CCONJ	CC	_	_	_	_	_
32	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	globins	globin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
41	IIb	IIb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12464
# text = 4) as well as Spi-1 and Fli-1 transcripts at permissive temperature.
1	4	4	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	as	as	ADV	RB	_	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
15	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12465
# text = Switching the cells to the nonpermissive temperature led to a marked increase in globin gene expression and concomitant decrease in expression of Spi-1, Fli-1, and megakaryocytic genes in an erythropoietin-dependent manner.
1	Switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nonpermissive	nonpermissive	ADJ	JJ	Degree=Pos	_	_	_	_
7	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	_
8	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
19	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12466
# text = Interestingly, enhanced expression of Spi-1 and Fli-1 genes already was detected in the Ter 119 positive cell population of transgenic mice spleen in vivo.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	already	already	ADV	RB	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Ter	Ter	NOUN	NN	Number=Sing	_	_	_	_
19	119	119	NUM	CD	NumType=Card	_	_	_	_
20	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	population	population	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
26	spleen	spleen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12467
# text = However, like normal Ter 119 erythroid cells, these Ter 119 positive cells from transgenic mice still expressed high levels of beta-globin and very low or undetectable glycoprotein IIb and platelet factor 4 megakaryocytic transcripts.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	like	like	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	Ter	Ter	PROPN	NNP	Number=Sing	_	_	_	_
6	119	119	NUM	CD	NumType=Card	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	Ter	Ter	NOUN	NN	Number=Sing	_	_	_	_
12	119	119	NUM	CD	NumType=Card	_	_	_	_
13	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
18	still	still	ADV	RB	_	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	very	very	ADV	RB	_	_	_	_	_
28	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
31	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
32	IIb	IIb	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	4	4	NUM	CD	NumType=Card	_	_	_	_
37	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12468
# text = Taken together, these data indicate that the unexpected expression of megakaryocytic genes is a specific property of immortalized cells that cannot be explained only by enhanced expression of Spi-1 and/or Fli-1 genes.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	unexpected	unexpected	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	property	property	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	immortalized	immortalized	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
23	not	not	PART	RB	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	or	or	CCONJ	CC	_	_	_	_	_
37	Fli	Fli	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12469
# text = Document 0030012995 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012995	0030012995	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12470
# text = EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes.
1	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	E47	E47	NUM	CD	NumType=Card	_	_	_	_
4	collaborate	collaborate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
12	surrogate	surrogate	NOUN	NN	Number=Sing	_	_	_	_
13	light	light	NOUN	NN	Number=Sing	_	_	_	_
14	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12471
# text = Early B cell factor (EBF) and E47 participate in the transcriptional control of early B lymphocyte differentiation.
1	Early	Early	ADV	RB	_	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	E47	E47	NUM	CD	NumType=Card	_	_	_	_
10	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	control	control	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12472
# text = With the aim of identifying genetic targets for these transcription factors, we stably transfected cDNAs encoding EBF or a covalent homodimer of E47, individually or together, into immature hematopoietic Ba/F3 cells, which lack both factors.
1	With	with	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	SCONJ	IN	_	_	_	_	_
5	identifying	identify	VERB	VBG	VerbForm=Ger	_	_	_	_
6	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	stably	stably	ADV	RB	_	_	_	_	_
15	transfected	transfect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	cDNAs	cDNAs	SCONJ	IN	_	_	_	_	_
17	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
18	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	covalent	covalent	ADJ	JJ	Degree=Pos	_	_	_	_
22	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	E47	E47	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	individually	individually	ADV	RB	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	into	into	ADP	IN	_	_	_	_	_
31	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
32	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
33	Ba/F3	Ba/F3	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	which	which	PRON	WDT	PronType=Rel	_	_	_	_
37	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	both	both	DET	DT	_	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12473
# text = In combination, EBF and E47 induce efficient expression of the endogenous immunoglobulin surrogate light chain genes, lambda5 and VpreB, whereas other pre-B cell-specific genes remain silent.
1	In	in	ADP	IN	_	_	_	_	_
2	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	E47	E47	NUM	CD	NumType=Card	_	_	_	_
7	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
8	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
13	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
14	surrogate	surrogate	NOUN	NN	Number=Sing	_	_	_	_
15	light	light	NOUN	NN	Number=Sing	_	_	_	_
16	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	lambda5	lambda5	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	VpreB	VpreB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
26	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12474
# text = Multiple functionally important EBF and E47 binding sites were identified in the lambda5 promoter/enhancer region, indicating that lambda5 is a direct genetic target for these transcription factors.
1	Multiple	multiple	PROPN	NNP	Number=Sing	_	_	_	_
2	functionally	functionally	ADV	RB	_	_	_	_	_
3	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
4	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	E47	E47	NUM	CD	NumType=Card	_	_	_	_
7	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	lambda5	lambda5	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	lambda5	lambda5	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
25	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
26	target	target	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12475
# text = Taken together, these data suggest that EBF and E47 synergize to activate expression of a subset of genes that define an early stage of the B cell lineage.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	EBF	EBF	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	E47	E47	NUM	CD	NumType=Card	_	_	_	_
11	synergize	synergize	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
24	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12476
# text = Document 0030012996 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012996	0030012996	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12477
# text = Characterization of the human platelet/endothelial cell adhesion molecule-1 promoter: identification of a GATA-2 binding element required for optimal transcriptional activity.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12478
# text = Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kD member of the Ig gene superfamily that is expressed on platelets, endothelial cells, and certain leukocyte subsets.
1	Platelet	Platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	130	130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
19	member	member	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	superfamily	superfamily	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
36	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
37	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12479
# text = To examine the factors controlling vascular-specific expression of PECAM-1, we cloned the 5'-flanking region of the PECAM-1 gene and analyzed its transcriptional activity.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
6	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	cloned	clon	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12480
# text = 5'-Rapid amplification of cDNA ends (5'-RACE) analysis showed that transcription initiation occurred at several closely spaced nearby sites originating approximately 204 bp upstream from the translation start site.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	Rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
5	amplification	amplification	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
8	ends	end	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
12	RACE	race	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	analysis	analysis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
19	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	closely	closely	ADV	RB	_	_	_	_	_
23	spaced	space	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	nearby	nearby	ADJ	JJ	Degree=Pos	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	originating	originat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	approximately	approximately	ADV	RB	_	_	_	_	_
28	204	204	NUM	CD	NumType=Card	_	_	_	_
29	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
30	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
34	start	start	NOUN	NN	Number=Sing	_	_	_	_
35	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12481
# text = Analysis of the sequence immediately upstream from the transcription initiation site (TIS) showed no canonical TATA or CAAT elements, however an initiator element commonly found in TATA-less promoters encompassed the TIS.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	immediately	immediately	ADV	RB	_	_	_	_	_
6	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TIS	TIS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	no	no	DET	DT	_	_	_	_	_
17	canonical	canonical	ADJ	JJ	Degree=Pos	_	_	_	_
18	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	CAAT	Caat	NOUN	NN	Number=Sing	_	_	_	_
21	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	however	however	ADV	RB	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	initiator	initiator	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	_
27	commonly	commonly	ADV	RB	_	_	_	_	_
28	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	TATA	TATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
33	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
34	encompassed	encompass	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	TIS	tis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12482
# text = 5'-serially truncated PECAM-1 promoter segments cloned in front of a luciferase reporter drove transcription in both a lineage- and orientation-specific manner.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	serially	serially	ADV	RB	_	_	_	_	_
5	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
11	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	front	front	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	drove	drive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	orientation	orientation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12483
# text = Putative cis-acting control elements present within a 300-bp core promoter included two ets sites, an Sp1 site, tandem E-box domains, two GATA-associated sites (CACCC), an AP-2 binding site, and a GATA element at -24.
1	Putative	Putative	ADJ	JJ	Degree=Pos	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
5	control	control	NOUN	NN	Number=Sing	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
7	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	300	300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
13	core	core	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
25	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	box	box	NOUN	NN	Number=Sing	_	_	_	_
27	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	CACCC	CACCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
43	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
48	element	element	NOUN	NN	Number=Sing	_	_	_	_
49	at	at	ADP	IN	_	_	_	_	_
50	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
51	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12484
# text = Mutational analysis showed that optimal transcriptional activity required the GATA sequence at position -24, and gel-shift assays further showed that the GATA-2 transcription factor, but not GATA-1, bound to this region of the PECAM-1 promoter.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	position	position	NOUN	NN	Number=Sing	_	_	_	_
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
21	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
22	further	further	ADV	RB	_	_	_	_	_
23	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	not	not	ADV	RB	_	_	_	_	_
34	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
41	region	region	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12485
# text = Understanding the cis- and transacting factors that regulate the tissue-specific expression of PECAM-1 should increase our understanding of the mechanisms by which vascular-specific gene expression is achieved.
1	Understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	transacting	transact	VERB	VBG	VerbForm=Ger	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	PECAM	PECAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
20	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
21	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
22	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12486
# text = Document 0030012998 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012998	0030012998	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12487
# text = Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.
1	Ectopic	Ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
6	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	chimera	chimera	NOUN	NN	Number=Sing	_	_	_	_
13	arrests	arrest	NOUN	NNS	Number=Plur	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12488
# text = The GATA factors are a family of transcriptional regulatory proteins in eukaryotes that share extensive homology in their DNA-binding domains.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	eukaryotes	eukaryote	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
16	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12489
# text = One enigmatic aspect of GATA factor expression is that several GATA proteins, which ostensibly share the same DNA-binding site specificity, are coexpressed in erythroid cells.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	enigmatic	enigmatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	aspect	aspect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
12	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	ostensibly	ostensibly	ADV	RB	_	_	_	_	_
16	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12490
# text = To elucidate the roles of individual GATA factors in erythropoiesis, conditional alleles of GATA-1, GATA-2, and GATA-3 were prepared by fusing each of the factors to the hormone-binding domain of the human estrogen receptor (ER).
1	To	to	PART	TO	_	_	_	_	_
2	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	erythropoiesis	erythropoiesis	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
13	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	SCONJ	IN	_	_	_	_	_
30	fusing	fuse	VERB	VBG	VerbForm=Ger	_	_	_	_
31	each	each	DET	DT	_	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
44	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	_
45	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12491
# text = These GATA/ER chimeric factors were shown to be hormone-inducible trans-activating proteins in transient transfection assays.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
4	ER	er	NOUN	NN	Number=Sing	_	_	_	_
5	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	hormone	hormone	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
20	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
21	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12492
# text = When stably introduced into primary erythroblasts or conditionally transformed erythroid progenitors cells, exogenous GATA-2/ER promoted proliferation and inhibited terminal differentiation in an estrogen-dependent manner.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	stably	stably	ADV	RB	Degree=Pos	_	_	_	_
3	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	into	into	ADP	IN	_	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	conditionally	conditionally	ADV	RB	_	_	_	_	_
9	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	exogenous	exogenous	CCONJ	CC	_	_	_	_	_
15	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2/ER	2/er	PROPN	NNP	Number=Sing	_	_	_	_
18	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
29	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12493
# text = These phenotypic effects are specifically attributable to the action of ectopically expressed GATA-2/ER because erythroblasts expressing exogenous GATA-2 are constitutively arrested in differentiation and because erythroid progenitors expressing either Gal/ER or GATA-3/ER do not display a hormone-responsive block in differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	ectopically	ectopically	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2/ER	2/er	PROPN	NNP	Number=Sing	_	_	_	_
16	because	because	SCONJ	IN	_	_	_	_	_
17	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
18	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
20	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	arrested	arrest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	because	because	SCONJ	IN	_	_	_	_	_
30	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
31	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
32	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
33	either	either	DET	DT	_	_	_	_	_
34	Gal/	Gal/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	ER	er	NOUN	NN	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-3/ER	-3/er	PROPN	NNP	Number=Sing	_	_	_	_
39	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	not	not	PART	RB	_	_	_	_	_
41	display	display	VERB	VB	VerbForm=Inf	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
46	block	block	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12494
# text = Thus, the GATA-2 transcription factor appears to play a role in regulating the self-renewal capacity of early erythroid progenitor cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	renewal	renewal	ADJ	JJ	Degree=Pos	_	_	_	_
20	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
23	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
24	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12495
# text = Document 0030012999 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030012999	0030012999	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12496
# text = Phorbol ester reduces constitutive nuclear NF kappa B and inhibits HIV-1 production in mature human monocytic cells.
1	Phorbol	Phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
2	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
3	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12497
# text = NF kappa B is a potent mediator of specific gene expression in human monocytes and has been shown to play a role in transcription of the HIV-1 genome in promonocytic leukemias.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
2	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
3	B	B	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12498
# text = There is little information available on the response of NF kappa B to cytokines in normal human monocytes.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	information	information	NOUN	NN	Number=Sing	_	_	_	_
5	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12499
# text = We have used a 32P-labeled oligonucleotide derived from human immunodeficiency virus (HIV-1) long terminal repeat, which contains a tandem repeat of the NF kappa B binding sequence, as a probe in a gel retardation assay to study this transcription factor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	32P	32p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	X	LS	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
20	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
21	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
27	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
34	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
42	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
43	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
44	to	to	PART	TO	_	_	_	_	_
45	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
46	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
47	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
48	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12500
# text = Using this assay, we have detected NF kappa B in extracts of nuclei from normal human monocytes.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12501
# text = Treatment of normal monocytes with 12-0-tetradecanoyl phorbol-13-acetate (TPA) for 4-24 h caused the complete disappearance of NF kappa B from nuclear extracts of monocytes.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	0	0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	tetradecanoyl	tetradecanoyl	NOUN	NN	Number=Sing	_	_	_	_
11	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	24	24	NUM	CD	NumType=Card	_	_	_	_
22	h	h	X	GW	_	_	_	_	_
23	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
26	disappearance	disappearance	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	B	PROPN	NNP	Number=Sing	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12502
# text = A similar result was obtained with the mature monocytic leukemia cell line THP-1.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	result	result	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12503
# text = The constitutive transcription factor SP1 was unaffected by addition of TPA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	SP1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	unaffected	unaffect	ADJ	JJ	Degree=Pos	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12504
# text = The disappearance of NF kappa B from the nucleus was concentration dependent between 10 and 50 ng/ml of phorbol ester.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	disappearance	disappearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	50	50	NUM	CD	NumType=Card	_	_	_	_
17	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
21	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12505
# text = In THP-1 cells, TPA also induced a new, faster-migrating NF kappa B species not induced in monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	faster	faster	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	migrating	migrating	VERB	VBG	VerbForm=Ger	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	species	species	NOUN	NNS	Number=Plur	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12506
# text = Protein kinase C inhibitor staurosporine, but not cyclic nucleotide-dependent protein kinase inhibitor HA-1004, also dramatically reduced constitutive levels of nuclear NF kappa B.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	NOUN	NN	Number=Sing	_	_	_	_
4	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
5	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
10	nucleotide	nucleotide	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	HA	ha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1004	1004	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	dramatically	dramatically	ADV	RB	_	_	_	_	_
22	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12507
# text = Finally, TPA addition to monocytes infected with HIV-1 inhibited HIV-1 replication, as determined by reverse transcriptase assays, in a concentration-dependent manner.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	reverse	reverse	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	_
23	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12508
# text = These results are in striking contrast to the increase in nuclear NF kappa B and HIV-1 replication induced by phorbol esters in promonocytic leukemia cells U937 and HL-60, and emphasize the importance of studying cytokine regulation of HIV-1 in normal monocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	striking	strik	ADJ	JJ	Degree=Pos	_	_	_	_
6	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	B	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
23	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	U937	U937	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	emphasize	emphasize	VERB	VB	VerbForm=Inf	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	SCONJ	IN	_	_	_	_	_
39	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
40	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
41	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
48	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12509
# text = Document 0030013016 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013016	0030013016	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12510
# text = Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
3	intermediate	intermediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	NADPH	NADPh	DET	DT	_	_	_	_	_
20	oxidase	oxidase	ADJ	JJ	Degree=Pos	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12511
# text = We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-kappaB activation by proinflammatory cytokines was cell specific.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
9	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
10	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ROIs	ROI	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	cell	cell	ADV	RB	Degree=Pos	_	_	_	_
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12512
# text = However, the sources for ROIs in various cell types are yet to be determined and might include 5-lipoxygenase (5-LOX) and NADPH oxidase.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	sources	source	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	ROIs	ROI	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	types	type	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	yet	yet	ADV	RB	_	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	determined	determined	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
18	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	5-	5-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	LOX	LOX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NADPH	NADPH	DET	DT	_	_	_	_	_
28	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12513
# text = 5-LOX and 5-LOX activating protein (FLAP) are coexpressed in lymphoid cells but not in monocytic or epithelial cells.
1	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	LOX	Lox	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	LOX	Lox	NOUN	NN	Number=Sing	_	_	_	_
8	activating	activating	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	FLAP	Flap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12514
# text = Stimulation of lymphoid cells with interleukin-1beta (IL-1beta) led to ROI production and NF-kappaB activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	FLAP	Flap	NOUN	NN	Number=Sing	_	_	_	_
34	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	confirming	confirm	VERB	VBG	VerbForm=Ger	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	LOX	LOX	NOUN	NN	Number=Sing	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	source	source	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	ROIs	ROI	NOUN	NNS	Number=Plur	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
48	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	for	for	ADP	IN	_	_	_	_	_
50	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
56	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12515
# text = IL-1beta stimulation of epithelial cells did not generate any ROIs and NF-kappaB induction was not influenced by 5-LOX inhibitors.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
4	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
11	any	any	DET	DT	_	_	_	_	_
12	ROIs	ROI	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	LOX	Lox	NUM	CD	NumType=Card	_	_	_	_
25	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12516
# text = However, reintroduction of a functional 5-LOX system in these cells allowed ROI production and 5-LOX-dependent NF-kappaB activation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	reintroduction	reintroduction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	LOX	Lox	NOUN	NN	Number=Sing	_	_	_	_
10	system	system	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	allowed	allow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	5-	5-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	LOX	LOX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12517
# text = In monocytic cells, IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity.
1	In	in	ADP	IN	_	_	_	_	_
2	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	bet	bet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
11	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	ROIs	ROI	NOUN	NNS	Number=Plur	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	LOX	Lox	NOUN	NN	Number=Sing	_	_	_	_
25	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	NADPH	NADPH	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
30	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12518
# text = This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
3	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Rac1	rac1	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Cdc42	cdc42	NOUN	NN	Number=Sing	_	_	_	_
8	GTPases	GTPase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12519
# text = In conclusion, three different cell-specific pathways lead to NF-kappaB activation by IL-1beta: a pathway dependent on ROI production by 5-LOX in lymphoid cells, an ROI- and 5-LOX-independent pathway in epithelial cells, and a pathway requiring ROI production by NADPH oxidase in monocytic cells.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	ROI	Roi	NUM	CD	NumType=Card	_	_	_	_
26	production	production	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	LOX	Lox	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	ROI	ROI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	LOX	Lox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
44	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
52	requiring	require	VERB	VBG	VerbForm=Ger	_	_	_	_
53	ROI	Roi	NUM	CD	NumType=Card	_	_	_	_
54	production	production	NOUN	NN	Number=Sing	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	NADPH	NADPH	DET	DT	_	_	_	_	_
57	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12520
# text = Document 0030013021 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013021	0030013021	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12521
# text = Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12522
# text = The expression of the hematopoietic transcription factors GATA-1, GATA-2, and GATA-3 was studied in eosinophils and basophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12523
# text = Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3.
1	Eosinophils	Eosinophils	INTJ	UH	_	_	_	_	_
2	express	express	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12524
# text = Basophils express GATA-2 and GATA-3.
1	Basophils	Basophil	NOUN	NNS	Number=Plur	_	_	_	_
2	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12525
# text = Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
7	sublines	subline	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	either	either	DET	DT	_	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	5	5	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	butyric	butyric	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
24	concomitant	concomitant	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	eosinophil	eosinophil	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	whereas	whereas	SCONJ	IN	_	_	_	_	_
35	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
41	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	relatively	relatively	ADV	RB	_	_	_	_	_
43	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12526
# text = The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	basophils	basophil	NOUN	NNS	Number=Plur	_	_	_	_
12	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12527
# text = Document 0030013026 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013026	0030013026	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12528
# text = Human monocyte binding to fibronectin enhances IFN-gamma-induced early signaling events.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	fibronectin	fibronectin	VERB	VB	VerbForm=Inf	_	_	_	_
6	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
7	IFN-	IFN-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	early	early	ADV	RB	Degree=Pos	_	_	_	_
12	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
13	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12529
# text = Leukocyte integrins are fundamentally important in modulating adhesion to extracellular matrix components and to other cells.
1	Leukocyte	Leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	integrins	integrin	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	fundamentally	fundamentally	ADV	RB	_	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	SCONJ	IN	_	_	_	_	_
7	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
12	components	component	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12530
# text = This integrin-mediated adhesion controls leukocyte arrest and extravasation during the onset of inflammatory responses.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	integrin-	integrin-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
7	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	extravasation	extravasation	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12531
# text = Moreover, integrin-ligand interactions trigger signaling pathways that may influence leukocyte phenotype and function at sites of inflammation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	integrin	integrin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
6	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
7	trigger	trigger	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
13	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
14	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12532
# text = In the current studies, we evaluated the combinatorial effects of monocyte adhesion and IFN-gamma on intracellular signaling pathways.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	combinatorial	combinatorial	ADJ	JJ	Degree=Pos	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
21	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12533
# text = IFN-gamma triggers a well-defined signal transduction pathway, which although not directly stimulated by monocyte adherence to fibronectin or arginine-glycine-aspartate (RGD)-coated substrata, was enhanced significantly in these matrix-adherent cells.
1	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	although	although	SCONJ	IN	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	directly	directly	ADV	RB	_	_	_	_	_
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
20	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	arginine	arginine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	glycine	glycine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	aspartate	aspartate	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	RGD	RGD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	coated	coate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	substrata	substrata	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	significantly	significantly	ADV	RB	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
41	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12534
# text = Compared with monocytes in suspension or adherent on plastic surfaces, monocytes adherent to fibronectin or RGD exhibited a greater than threefold increase in steady state levels of IFN-gamma-induced mRNA for the high affinity Fc gammaRI receptor.
1	Compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	suspension	suspension	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	adherent	adherent	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
10	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	fibronectin	fibronectin	VERB	VB	VerbForm=Inf	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	RGD	RGD	PROPN	NNP	Number=Sing	_	_	_	_
18	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
21	than	than	ADP	IN	_	_	_	_	_
22	threefold	threefold	NOUN	NN	Number=Sing	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
26	state	state	NOUN	NN	Number=Sing	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
37	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
38	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
39	gammaRI	gammaRI	PROPN	NNP	Number=Sing	_	_	_	_
40	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12535
# text = By electrophoretic mobility shift assays, this increase in mRNA was associated with a 5- to 10-fold increase in the STAT1-containing DNA-binding complex that binds to Fc gammaRI promoter elements.
1	By	by	ADP	IN	_	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
21	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	STAT1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
35	gammaRI	gammaRI	PROPN	NNP	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12536
# text = Furthermore, the tyrosine phosphorylation of STAT1 and the tyrosine kinases JAK1 and JAK2 was enhanced significantly in RGD-adherent monocytes compared with control cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
12	JAK1	JAK1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	JAK2	JAK2	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	RGD-	RGD-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	control	control	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12537
# text = These results suggest a novel mechanism by which integrin-mediated cell adhesion can modulate the magnitude of cytokine-induced signal transduction pathways, thereby amplifying cellular events leading to monocyte activation and inflammation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	integrin-	integrin-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
22	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
23	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	thereby	thereby	ADV	RB	_	_	_	_	_
26	amplifying	amplify	VERB	VBG	VerbForm=Ger	_	_	_	_
27	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	events	event	NOUN	NNS	Number=Plur	_	_	_	_
29	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12538
# text = Document 0030013028 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013028	0030013028	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12539
# text = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.
1	Repression	Repression	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	Ikaros	Ikaros	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	histone	histone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12540
# text = Here we show that the lymphoid lineage-determining factors
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
7	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 12541
# text = Ikaros and Aiolos can function as strong transcriptional repressors.
1	Ikaros	Ikaros	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12542
# text = This function is mediated through two repression domains and is dependent upon the promoter context and cell type.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
8	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	upon	upon	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	context	context	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12543
# text = Repression by Ikaros proteins correlates with hypo-acetylation of core histones at promoter sites and is relieved by histone deacetylase inhibitors.
1	Repression	Repression	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	Ikaros	Ikaros	PROPN	NNP	Number=Sing	_	_	_	_
4	proteins	proteins	NOUN	NNS	Number=Plur	_	_	_	_
5	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	hypo-acetylation	hypo-acetylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	core	core	ADJ	JJ	Degree=Pos	_	_	_	_
10	histones	histone	NOUN	NNS	Number=Plur	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	relieved	relieve	ADJ	JJ	Degree=Pos	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	histone	histone	PRON	NN	Number=Sing	_	_	_	_
19	deacetylase	deacetylase	ADJ	JJ	Degree=Pos	_	_	_	_
20	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12544
# text = Consistent with these findings, Ikaros and its repression domains can interact in vivo and in vitro with the mSin3 family of co-repressors which bind to histone deacetylases.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Ikaros	Ikaros	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
10	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	mSin3	mSin3	NOUN	NN	Number=Sing	_	_	_	_
21	family	family	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	co-repressors	co-repressor	NOUN	NNS	Number=Plur	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	histone	histone	VERB	VB	VerbForm=Inf	_	_	_	_
28	deacetylases	deacetylase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12545
# text = Based on these and our recent findings of associations between Ikaros and Mi-2-HDAC, we propose that Ikaros family members modulate gene expression during lymphocyte development by recruiting distinct histone deacetylase complexes to specific promoters.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
7	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	associations	association	NOUN	NNS	Number=Plur	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	Ikaros	Ikaros	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Mi	Mi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	HDAC	Hdac	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	Ikaros	Ikaros	PROPN	NNP	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	members	member	NOUN	NNS	Number=Plur	_	_	_	_
24	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	SCONJ	IN	_	_	_	_	_
31	recruiting	recruit	VERB	VBG	VerbForm=Ger	_	_	_	_
32	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
33	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
34	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
35	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12546
# text = Document 0030013032 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013032	0030013032	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12547
# text = Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription.
1	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
6	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
25	ligand	ligand	NUM	CD	NumType=Card	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12548
# text = Bcl-2 inhibits apoptosis induced by a variety of stimuli, including chemotherapy drugs and glucocorticoids.
1	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	_
15	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12549
# text = It is generally accepted that Bcl-2 exerts its antiapoptotic effects mainly by dimerizing with proapoptotic members of the Bcl-2 family such as Bax and Bad.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	generally	generally	ADV	RB	_	_	_	_	_
4	accepted	accept	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
13	mainly	mainly	ADV	RB	_	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	dimerizing	dimerize	VERB	VBG	VerbForm=Ger	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	proapoptotic	proapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	Bax	Bax	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Bad	Bad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12550
# text = However, the mechanism of the antiapoptotic effects is unclear.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	antiapoptotic	antiapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12551
# text = Paclitaxel and other drugs that disturb microtubule dynamics kill cells in a Fas/Fas ligand (FasL)-dependent manner; antibody to FasL inhibits paclitaxel-induced apoptosis.
1	Paclitaxel	Paclitaxel	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	disturb	disturb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	microtubule	microtubule	ADJ	JJ	Degree=Pos	_	_	_	_
8	dynamics	dynamics	NOUN	NNS	Number=Plur	_	_	_	_
9	kill	kill	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
16	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	FasL	FasL	INTJ	UH	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
27	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
28	paclitaxel	paclitaxel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12552
# text = We have found that Bcl-2 overexpression leads to the prevention of chemotherapy (paclitaxel)-induced expression of FasL and blocks paclitaxel-induced apoptosis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
9	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	prevention	prevention	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	paclitaxel	paclitaxel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	FasL	Fasl	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
25	paclitaxel	paclitaxel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12553
# text = The mechanism of this effect is that Bcl-2 prevents the nuclear translocation of NFAT (nuclear factor of activated T lymphocytes, a transcription factor activated by microtubule damage) by binding and sequestering calcineurin, a calcium-dependent phosphatase that must dephosphorylate NFAT to move to the nucleus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T	t	NOUN	NN	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	microtubule	microtubule	ADJ	JJ	Degree=Pos	_	_	_	_
31	damage	damage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	by	by	SCONJ	IN	_	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	sequestering	sequester	VERB	VBG	VerbForm=Ger	_	_	_	_
37	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
43	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
46	dephosphorylate	dephosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
47	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
48	to	to	PART	TO	_	_	_	_	_
49	move	move	VERB	VB	VerbForm=Inf	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12554
# text = Without NFAT nuclear translocation, the FasL gene is not transcribed.
1	Without	without	ADP	IN	_	_	_	_	_
2	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12555
# text = Thus, it appears that paclitaxel and other drugs that disturb microtubule function kill cells at least in part through the induction of FasL.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	paclitaxel	paclitaxel	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	disturb	disturb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	microtubule	microtubule	ADJ	JJ	Degree=Pos	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	kill	kill	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	at	at	ADV	RB	_	_	_	_	_
17	least	least	ADV	RBS	Degree=Sup	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	part	part	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	FasL	FasL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12556
# text = Furthermore, Bcl-2 antagonizes drug-induced apoptosis by inhibiting calcineurin activation, blocking NFAT nuclear translocation, and preventing FasL expression.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	antagonizes	antagonize	NOUN	NNS	Number=Plur	_	_	_	_
7	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
13	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
17	NFAT	Nfat	PRON	WP	PronType=Int	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
23	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12557
# text = The effects of Bcl-2 can be overcome, at least partially, through phosphorylation of Bcl-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	overcome	overcome	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	at	at	ADV	RB	_	_	_	_	_
12	least	least	ADV	RBS	Degree=Sup	_	_	_	_
13	partially	partially	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12558
# text = Phosphorylated Bcl-2 cannot bind calcineurin, and NFAT activation, FasL expression, and apoptosis can occur after Bcl-2 phosphorylation.
1	Phosphorylated	Phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
6	not	not	PART	RB	_	_	_	_	_
7	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
8	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12559
# text = Document 0030013033 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013033	0030013033	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12560
# text = NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
12	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12561
# text = During beneficial inflammation, potentially tissue-damaging granulocytes undergo apoptosis before being cleared by phagocytes in a non-phlogistic manner.
1	During	during	ADP	IN	_	_	_	_	_
2	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
3	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	potentially	potentially	ADV	RB	_	_	_	_	_
6	tissue	tissue	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
7	-damaging	-damage	VERB	VBG	VerbForm=Ger	_	_	_	_
8	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	undergo	undergo	ADJ	JJ	Degree=Pos	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	before	before	SCONJ	IN	_	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	cleared	cleare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	non-phlogistic	non-phlogistic	ADJ	JJ	Degree=Pos	_	_	_	_
19	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12562
# text = Here we show that the rate of constitutive apoptosis in human neutrophils and eosinophils is greatly accelerated in both a rapid and concentration-dependent manner by the fungal metabolite gliotoxin, but not by its inactive analog methylthiogliotoxin.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	greatly	greatly	ADV	RB	_	_	_	_	_
17	accelerated	accelerate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	rapid	rapid	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	fungal	fungal	ADJ	JJ	Degree=Pos	_	_	_	_
30	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
31	gliotoxin	gliotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
37	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
38	analog	analog	NOUN	NN	Number=Sing	_	_	_	_
39	methylthiogliotoxin	methylthiogliotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12563
# text = This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
10	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
11	zVAD	zvad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=1|Tense=Past|VerbForm=Fin	_	_	_	_
33	mimicked	mimick	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	permeable	permeable	ADJ	JJ	Degree=Pos	_	_	_	_
38	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
39	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	SN	SN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	;	;	PUNCT	,	_	_	_	_	_
49	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
50	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
53	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	curcumin	curcumin	NOUN	NNS	Number=Plur	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
58	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	;	;	PUNCT	,	_	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
63	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	MG	MG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	132	132	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12564
# text = Gliotoxin also augmented dramatically the early (2-6
1	Gliotoxin	Gliotoxin	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	dramatically	dramatically	ADV	RB	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12565
# text = h) pro-apoptotic effects of tumor necrosis factor-alpha (TNF-alpha) in neutrophils and unmasked the ability of TNF-alpha to induce eosinophil apoptosis.
1	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	pro-apoptotic	pro-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	unmasked	unmask	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
28	eosinophil	eosinophil	ADP	IN	_	_	_	_	_
29	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12566
# text = In neutrophils, TNF-alpha caused a gliotoxin-inhibitable activation of an inducible form of NF-kappaB, a response that may underlie the ability of TNF-alpha to delay apoptosis at later times (12-24 h) and limit its early killing effect.
1	In	in	ADP	IN	_	_	_	_	_
2	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
7	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	gliotoxin	gliotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	inhibitable	inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	delay	delay	VERB	VB	VerbForm=Inf	_	_	_	_
35	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
38	times	time	NOUN	NNS	Number=Plur	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	24	24	NUM	CD	NumType=Card	_	_	_	_
43	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	limit	limit	VERB	VB	VerbForm=Inf	_	_	_	_
47	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
48	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	early	early	ADV	RB	Degree=Pos	_	_	_	_
50	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	_
51	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12567
# text = Furthermore, cycloheximide displayed a similar capacity to enhance TNF-alpha induced neutrophil apoptosis even at time points when cycloheximide alone had no pro-apoptotic effect, suggesting that NF-kappaB may regulate the production of protein(s) which protect neutrophils from the cytotoxic effects of TNF-alpha.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	_
4	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
15	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	even	even	ADV	RB	_	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	time	time	NOUN	NN	Number=Sing	_	_	_	_
19	points	point	NOUN	NNS	Number=Plur	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	cycloheximide	cycloheximide	ADJ	JJ	Degree=Pos	_	_	_	_
22	alone	alone	ADV	RB	_	_	_	_	_
23	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	no	no	DET	DT	_	_	_	_	_
25	pro-apoptotic	pro-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	s	s	X	AFX	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	which	which	PRON	WDT	PronType=Rel	_	_	_	_
43	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
44	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
45	from	from	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
48	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12568
# text = These data shed light on the biochemical and molecular mechanisms regulating human granulocyte apoptosis and, in particular, indicate that the transcription factor NF-kappaB plays a crucial role in regulating the physiological cell death pathway in granulocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	shed	sh	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	light	light	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
10	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
11	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	indicate	indicate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	SCONJ	IN	_	_	_	_	_
33	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	death	death	NOUN	NN	Number=Sing	_	_	_	_
38	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12569
# text = Document 0030013034 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013034	0030013034	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12570
# text = Tissue and cell-type specific expression of the tuberous sclerosis gene, TSC2, in human tissues.
1	Tissue	Tissue	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tuberous	tuberous	ADJ	JJ	Degree=Pos	_	_	_	_
11	sclerosis	sclerosis	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	TSC2	TSC2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12571
# text = TSC2 is a gene on chromosome 16p13.3 associated with the autosomal dominant neurocutaneous disorder, tuberous sclerosis complex (TSC).
1	TSC2	Tsc2	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	chromosome	chromosome	DET	DT	_	_	_	_	_
7	16p13.3	16p13.3	NOUN	NN	Number=Sing	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	autosomal	autosomal	ADJ	JJ	Degree=Pos	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
13	neurocutaneous	neurocutaneous	ADJ	JJ	Degree=Pos	_	_	_	_
14	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	tuberous	tuberous	ADJ	JJ	Degree=Pos	_	_	_	_
17	sclerosis	sclerosis	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TSC	TSC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12572
# text = By using a partial nucleotide sequence from the cloned TSC2 and polymerase chain reaction methodology, we constructed a digoxigenin-labeled complementary DNA probe to examine TSC2 gene expression in autopsy- or biopsy-derived human tissues by in situ hybridization.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
5	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cloned	cloned	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	TSC2	Tsc2	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
15	methodology	methodology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	constructed	construct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	digoxigenin	digoxigenin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	labeled	labele	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
28	TSC2	TSC2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	autopsy	autopsy	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	biopsy	biopsy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
43	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12573
# text = TSC2 messenger RNA was widely expressed in various cell types throughout the body, including epithelia, lymphocytes, and cells with endocrine functions, e.g., adrenal cortex and anterior pituitary.
1	TSC2	TSC2	NUM	CD	NumType=Card	_	_	_	_
2	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
3	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	widely	widely	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	types	type	NOUN	NNS	Number=Plur	_	_	_	_
11	throughout	throughout	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	body	body	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	epithelia	epithelion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
24	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
29	cortex	cortex	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	anterior	anterior	ADJ	JJ	Degree=Pos	_	_	_	_
32	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12574
# text = It was prominently and selectively (within the central nervous system) expressed in pyramidal cells of the cerebral cortex and other motor neurons, e.g., in spinal cord and brainstem nuclei.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	prominently	prominently	ADV	RB	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	selectively	selectively	ADV	RB	_	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	within	within	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
10	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
11	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	pyramidal	pyramidal	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cerebral	cerebral	ADJ	JJ	Degree=Pos	_	_	_	_
20	cortex	cortex	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	motor	motor	NOUN	NN	Number=Sing	_	_	_	_
24	neurons	neuron	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	spinal	spinal	ADJ	JJ	Degree=Pos	_	_	_	_
30	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	brainstem	brainstem	NOUN	NN	Number=Sing	_	_	_	_
33	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12575
# text = Visceral TSC2 expression was comparable in autopsy tissues from patients with and without TSC; TSC2 messenger RNA expression was most prominent in cells with a rapid mitotic rate and turnover, e.g., epithelia and lymphocytes, with central nervous system pyramidal cells and other neurons being an obvious exception, and/or in cells with important secretory/transport functions.
1	Visceral	Visceral	ADJ	JJ	Degree=Pos	_	_	_	_
2	TSC2	Tsc2	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	autopsy	autopsy	ADJ	JJ	Degree=Pos	_	_	_	_
8	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	without	without	ADP	IN	_	_	_	_	_
14	TSC	Tsc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	TSC2	TSC2	NUM	CD	NumType=Card	_	_	_	_
17	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
18	RNA	RNa	SYM	SYM	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
28	mitotic	mitotic	ADJ	JJ	Degree=Pos	_	_	_	_
29	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	epithelia	epithelia	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
41	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
42	system	system	NOUN	NN	Number=Sing	_	_	_	_
43	pyramidal	pyramidal	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
47	neurons	neuron	NOUN	NNS	Number=Plur	_	_	_	_
48	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
49	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	obvious	obvious	ADJ	JJ	Degree=Pos	_	_	_	_
51	exception	exception	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
54	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
55	or	or	CCONJ	CC	_	_	_	_	_
56	in	in	ADP	IN	_	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
58	with	with	ADP	IN	_	_	_	_	_
59	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
60	secretory	secretory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
62	transport	transport	NOUN	NN	Number=Sing	_	_	_	_
63	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12576
# text = This widespread expression of the TSC2 gene supports the view that it encodes a protein vital to cell growth and metabolism or one that functions as a tumor/growth suppressor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TSC2	Tsc2	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	view	view	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	vital	vital	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	one	one	NUM	CD	NumType=Card	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
31	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12577
# text = Document 0030013035 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013035	0030013035	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12578
# text = Retinoid X receptor and c-cerbA/thyroid hormone receptor regulate erythroid cell growth and differentiation.
1	Retinoid	Retinoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	X	x	ADP	IN	_	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	cerbA	cerba	SYM	SYM	_	_	_	_	SpaceAfter=No
7	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
8	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
9	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	regulate	regulate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12579
# text = Nuclear receptors are important regulators of erythroid cell development.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12580
# text = Here we investigated the impact of retinoid X receptor (RXR), retinoic acid receptor (RAR), and of the c-erbA/thyroid hormone (T3) receptor (c-erbA/TR) on growth and differentiation of erythroid cells using an in vitro culture system of stem cell factor-dependent erythroid progenitors.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	impact	impact	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	X	x	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
28	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	TR	TR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
47	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
50	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
51	system	system	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
54	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
55	factor-dependent	factor-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
56	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
57	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12581
# text = RXR, RAR, and c-erbA/TR-specific ligands were found to induce erythroid-specific gene expression and to accelerate erythroid differentiation in culture, with T3 being most effective.
1	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	erbA/TR-specific	erbA/TR-specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	accelerate	accelerate	VERB	VB	VerbForm=Inf	_	_	_	_
21	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	with	with	SCONJ	IN	_	_	_	_	_
27	T3	T3	NOUN	NN	Number=Sing	_	_	_	_
28	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
29	most	most	ADV	RBS	_	_	_	_	_
30	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12582
# text = Furthermore, while ligand-activated c-erbA/TR accelerated differentiation, unliganded c-erbA/TR effectively blocked differentiation and supported sustained progenitor growth in culture.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	erbA/TR	erba/tr	ADV	RBR	Degree=Cmp	_	_	_	_
9	accelerated	accelerate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	unliganded	unliganded	ADJ	JJ	Degree=Pos	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	erbA/TR	erbA/TR	ADV	RBR	Degree=Cmp	_	_	_	_
15	effectively	effectively	ADV	RB	_	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	supported	support	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	sustained	sustain	ADJ	JJ	Degree=Pos	_	_	_	_
21	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12583
# text = Thus, c-erbA/TR appears to act as a binary switch affecting erythroid cell fate: unliganded c-erbA/TR supports growth while ligand-activated c-erbA/TR induces differentiation.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	erbA/TR	erbA/TR	PROPN	NNP	Number=Sing	_	_	_	_
5	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	binary	binary	NOUN	NN	Number=Sing	_	_	_	_
11	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
12	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	fate	fate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	unliganded	unliganded	ADJ	JJ	Degree=Pos	_	_	_	_
18	c-erbA/TR	c-erba/tr	NOUN	NN	Number=Sing	_	_	_	_
19	supports	support	NOUN	NNS	Number=Plur	_	_	_	_
20	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
21	while	while	SCONJ	IN	_	_	_	_	_
22	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	erbA/TR	erba/tr	ADJ	JJR	Degree=Cmp	_	_	_	_
27	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12584
# text = Additionally, to determine the impact of RXR for erythroid cell development, dominant interfering mutant RXRs, lacking the transcriptional activator functions AF-1 and AF-2, or AF-2 only, or the entire DNA-binding domain, were introduced into erythroid progenitor cells via recombinant retrovirus vectors and analyzed for RXR-specific effects.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	impact	impact	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	RXR	Rxr	PROPN	NNP	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	dominant	dominant	NOUN	NN	Number=Sing	_	_	_	_
15	interfering	interfere	VERB	VBG	VerbForm=Ger	_	_	_	_
16	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
17	RXRs	RXR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
23	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
24	AF	Af	ADV	RB	_	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	AF	Af	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	AF	Af	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	only	only	ADV	RB	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
41	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
44	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	introduced	introduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	into	into	ADP	IN	_	_	_	_	_
49	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
50	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
52	via	via	ADP	IN	_	_	_	_	_
53	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
54	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	_
55	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	for	for	ADP	IN	_	_	_	_	_
59	RXR-	RXR-	X	AFX	_	_	_	_	SpaceAfter=No
60	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
61	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12585
# text = It was found that expression of wild-type RXR and of the RXR mutants devoid of AF-1 and/or AF-2 supported a transient outgrowth of erythroid cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
15	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
16	devoid	devoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	AF	AF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	or	or	CCONJ	CC	_	_	_	_	_
24	AF	Af	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	supported	support	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
30	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12586
# text = In marked contrast, expression of the dominant interfering deltaDNA-binding domain RXR, containing a deletion of the entire DNA-binding domain, was incompatible with erythroid cell growth in vitro, suggesting a pivotal role of RXR for erythroid cell development.
1	In	in	ADP	IN	_	_	_	_	_
2	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	interfering	interfering	NOUN	NN	Number=Sing	_	_	_	_
10	deltaDNA	deltaDNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
14	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	incompatible	incompatible	ADJ	JJ	Degree=Pos	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
39	role	role	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
45	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12587
# text = Document 0030013037 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013037	0030013037	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12588
# text = Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers.
1	Protease	Protease	NOUN	NN	Number=Sing	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	block	block	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	ADJ	JJ	Degree=Pos	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	p65	p65	NUM	CD	NumType=Card	_	_	_	_
24	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12589
# text = Tissue factor (TF) is expressed rapidly by human monocytes exposed to bacterial endotoxin (lipopolysaccharide, or LPS).
1	Tissue	Tissue	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	TF	TF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	rapidly	rapidly	ADV	RB	_	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
15	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12590
# text = Transcriptional regulation is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site in the TF promoter.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	SCONJ	IN	_	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p65	p65	NUM	CD	NumType=Card	_	_	_	_
12	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12591
# text = Nuclear translocation of cytosolic c-Rel/p65 heterodimers and other members of the NF-kappa B/Rel family requires dissociation and proteolytic degradation of the inhibitor protein, I kappa B alpha.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytosolic	cytosolic	NOUN	NN	Number=Sing	_	_	_	_
5	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	p65	p65	NUM	CD	NumType=Card	_	_	_	_
9	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
12	members	member	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
21	family	family	NOUN	NN	Number=Sing	_	_	_	_
22	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	b	PROPN	NNP	Number=Sing	_	_	_	_
35	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12592
# text = The protease inhibitors N alpha-tosylphenylalanyl chloromethyl ketone (TPCK) and N alpha-tosyl-L-lysine chloromethyl ketone (TLCK) block activation of NF-kappa B/Rel proteins by preventing degradation of I kappa B alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
3	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
4	N	and	CCONJ	CC	Abbr=Yes	_	_	_	_
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	tosylphenylalanyl	tosylphenylalanyl	NOUN	NN	Number=Sing	_	_	_	_
8	chloromethyl	chloromethyl	NOUN	NN	Number=Sing	_	_	_	_
9	ketone	ketone	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TPCK	TPCK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	N	N	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	tosyl	tosyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	L	l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	lysine	lysine	NOUN	NN	Number=Sing	_	_	_	_
21	chloromethyl	chloromethyl	NOUN	NN	Number=Sing	_	_	_	_
22	ketone	ketone	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TLCK	TLCK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	block	block	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
35	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
36	by	by	SCONJ	IN	_	_	_	_	_
37	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
38	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
41	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
42	B	B	PROPN	NNP	Number=Sing	_	_	_	_
43	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12593
# text = To determine if TPCK and TLCK inhibited LPS induction of TF expression, freshly isolated human monocytes and monocytic THP-1 cells were pretreated with these inhibitors for 30 min before LPS stimulation.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	if	if	SCONJ	IN	_	_	_	_	_
4	TPCK	TPCK	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	TLCK	TLCK	PROPN	NNP	Number=Sing	_	_	_	_
7	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	freshly	freshly	ADV	RB	_	_	_	_	_
15	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	30	30	NUM	CD	NumType=Card	_	_	_	_
31	min	min	NOUN	NNS	Number=Plur	_	_	_	_
32	before	before	ADP	IN	_	_	_	_	_
33	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
34	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12594
# text = Both TPCK and TLCK inhibited LPS induction of TF protein, TF mRNA and TF promoter activity in a dose-dependent manner.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	TPCK	TPCK	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	TLCK	TLCK	PROPN	NNP	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12595
# text = These inhibitors specifically prevented degradation of I kappa B alpha and nuclear translocation of c-Rel/p65 heterodimers.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	specifically	specifically	ADV	RB	_	_	_	_	_
4	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	p65	p65	NUM	CD	NumType=Card	_	_	_	_
20	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12596
# text = In contrast, TPCK and TLCK did not block induction of an immediate-early gene encoding the transcription factor, Egr-1.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TPCK	TPCK	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	TLCK	TLCK	PROPN	NNP	Number=Sing	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12597
# text = Taken together, these data indicated that inhibiting nuclear translocation of c-Rel/p65 heterodimers prevented LPS induction of TF gene transcription in monocytic cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	p65	p65	NUM	CD	NumType=Card	_	_	_	_
17	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
18	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12598
# text = Document 0030013044 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013044	0030013044	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12599
# text = Increased interleukin 2 transcription in murine lymphocytes by ciprofloxacin.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	interleukin	interleukin	ADV	RB	_	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	ciprofloxacin	ciprofloxacin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12600
# text = The fluoroquinolone antibiotic, ciprofloxacin (cipro), induces hyperproduction of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) in stimulated human peripheral blood lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	fluoroquinolone	fluoroquinolone	NOUN	NN	Number=Sing	_	_	_	_
3	antibiotic	antibiotic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	ciprofloxacin	ciprofloxacin	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	cipro	cipro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	hyperproduction	hyperproduction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	stimulated	stimulate	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
33	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12601
# text = In this investigation an enhanced and prolonged IL-2 and IL-2 mRNA response was also detected in both stimulated (T cell mitogens or alloantigens) murine splenocytes and in the stimulated murine T cell line EL-4 in the presence of ciprofloxacin (5-80 micrograms/ml) as compared to control cells without antibiotics.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	T	t	NUM	CD	NumType=Card	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	alloantigens	alloantigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
31	splenocytes	splenocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
37	T	t	NUM	CD	NumType=Card	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	line	line	NOUN	NN	Number=Sing	_	_	_	_
40	EL	El	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	4	4	NUM	CD	NumType=Card	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	ciprofloxacin	ciprofloxacin	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
51	80	80	NUM	CD	NumType=Card	_	_	_	_
52	micrograms	microgram	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
54	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	_
56	as	as	SCONJ	IN	_	_	_	_	_
57	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	to	to	PART	TO	_	_	_	_	_
59	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
61	without	without	ADP	IN	_	_	_	_	_
62	antibiotics	antibiotic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12602
# text = However, in contrast to human lymphocytes, IFN-gamma production was inhibited and IFN-gamma mRNA levels were unaffected at 24 h and only slightly upregulated at 48 and 72 h of culture in murine splenocytes incubated with cipro (20 micrograms/ml).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IFN	Ifn	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	unaffected	unaffect	ADJ	JJ	Degree=Pos	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	24	24	NUM	CD	NumType=Card	_	_	_	_
25	h	h	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	slightly	slightly	ADV	RB	_	_	_	_	_
29	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	48	48	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	72	72	NUM	CD	NumType=Card	_	_	_	_
34	h	h	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
39	splenocytes	splenocyte	NOUN	NNS	Number=Plur	_	_	_	_
40	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	cipro	cipro	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	20	20	NUM	CD	NumType=Card	_	_	_	_
45	micrograms	microgram	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
47	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12603
# text = EL-4 cells were transfected with a plasmid containing the IL-2 promoter and enhancer region linked to the chloramphenicol acetyltransferase (CAT) reporter gene.
1	EL	EL	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
23	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12604
# text = Analysis of CAT activity revealed that cipro enhanced IL-2 gene induction.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	cipro	cipro	PROPN	NNP	Number=Sing	_	_	_	_
8	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12605
# text = In addition, EL-4 cells incubated with ciprofloxacin showed an early peak and more activated nuclear factor of activated T cells (NFAT-1) as compared to control cells without antibiotics.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	EL	EL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	ciprofloxacin	ciprofloxacin	NOUN	NN	Number=Sing	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	more	more	ADV	RBR	_	_	_	_	_
17	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	without	without	ADP	IN	_	_	_	_	_
35	antibiotics	antibiotic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12606
# text = Cipro did not affect the nuclear transcription factors AP-1 or NFIL-2A.
1	Cipro	Cipro	PROPN	NNP	Number=Sing	_	_	_	_
2	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	NFIL	Nfil	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2A	2a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12607
# text = Taken together, cipro inhibited IFN-gamma synthesis, but enhanced IL-2 production in murine lymphocytes by means of influencing NFAT-1 and causing an increased IL-2 transcription.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cipro	cipro	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	means	mean	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	SCONJ	IN	_	_	_	_	_
23	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
24	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12608
# text = Document 0030013046 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013046	0030013046	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12609
# text = Interleukin-12 expression in B cells by transformation with Epstein-Barr virus.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12610
# text = Although interleukin (IL)-12 was originally purified from an Epstein-Barr (EBV)-transformed B cell line and the high correlation of EBV infection and IL-12 expression has been suggested, no study has reported whether EBV infection is directly linked to IL-12 expression.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	12	12	NUM	CD	NumType=Card	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	originally	originally	ADV	RB	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
30	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	12	12	NUM	CD	NumType=Card	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	no	no	DET	DT	_	_	_	_	_
41	study	study	NOUN	NN	Number=Sing	_	_	_	_
42	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	whether	whether	SCONJ	IN	_	_	_	_	_
45	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
46	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
47	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	directly	directly	ADV	RB	_	_	_	_	_
49	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	12	12	NUM	CD	NumType=Card	_	_	_	_
54	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12611
# text = To address this issue, we have investigated IL-12 expression in B cells during in vitro transformation with EBV.
1	To	to	PART	TO	_	_	_	_	_
2	address	address	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	issue	issue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12612
# text = Human peripheral B cells became capable of constitutively producing p40 by in vitro transformation with EBV, coincident with the expression of latent membrane protein 1 (LMP1) of EBV.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	became	become	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	SCONJ	IN	_	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
10	p40	p40	NUM	CD	NumType=Card	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
14	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	coincident	coincident	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
24	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12613
# text = These B cells expressed p40 and p35 mRNA, and phorbol myristate acetate (PMA) stimulation strongly enhanced p40 and p70 production.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	p40	p40	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p35	p35	NUM	CD	NumType=Card	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
12	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
13	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	strongly	strongly	ADV	RB	_	_	_	_	_
19	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	p40	p40	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p70	p70	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12614
# text = Furthermore, transfection with LMP1 expression vector into a human B lymphoma cell line, Daudi, led to p40 production with nuclear factor (NF)-kappaB activation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
8	into	into	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	p40	p40	NUM	CD	NumType=Card	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12615
# text = These results suggest that transformation of primary B cells with EBV induces IL-12 expression potentially through LMP1 expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
12	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	12	12	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	potentially	potentially	ADV	RB	_	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12616
# text = Copyright 1998 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1998	1998	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12617
# text = Document 0030013051 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013051	0030013051	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12618
# text = Downstream activation of a TATA-less promoter by Oct-2, Bob1, and NF-kappaB directs expression of the homing receptor BLR1 to mature B cells.
1	Downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	less	less	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Bob1	bob1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	directs	direct	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	homing	home	VERB	VBG	VerbForm=Ger	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	BLR1	BLR1	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12619
# text = The chemokine receptor, BLR1, is a major regulator of the microenvironmental homing of B cells in lymphoid organs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	BLR1	BLR1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	microenvironmental	microenvironmental	ADJ	JJ	Degree=Pos	_	_	_	_
14	homing	homing	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12620
# text = In vitro studies identify three essential elements of the TATA-less blr1 core promoter that confer cell type- and differentiation-specific expression in the B cells of both humans and mice, a functional promoter region (-36 with respect to the transcription start site), a NF-kappaB motif (+44), and a noncanonical octamer motif (+157).
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	three	three	NUM	CD	NumType=Card	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
13	blr1	blr1	NUM	CD	NumType=Card	_	_	_	_
14	core	core	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	confer	confer	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	humans	humans	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	36	36	NUM	CD	NumType=Card	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
48	start	start	NOUN	NN	Number=Sing	_	_	_	_
49	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
56	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	+44	+44	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
60	,	,	PUNCT	,	_	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
63	noncanonical	noncanonical	ADJ	JJ	Degree=Pos	_	_	_	_
64	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
65	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	+157	+157	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12621
# text = The importance of these sites was confirmed by in vivo studies in gene-targeted mice deficient of either Oct-2, Bob1, or both NF-kappaB subunits p50 and p52.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
11	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
17	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	either	either	CCONJ	CC	_	_	_	_	_
20	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Bob1	bob1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
31	p50	p50	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12622
# text = In all of these animals, the expression of BLR1 was reduced or absent.
1	In	in	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	BLR1	BLR1	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12623
# text = In mice deficient only of p52/NF-kappaB, BLR1 expression was unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	mice	mice	NOUN	NN	Number=Sing	_	_	_	_
3	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p52/	p52ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	BLR1	BLR1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12624
# text = Thus our data demonstrate that BLR1 is a target gene for Oct-2, Bob1, and members of the NF-kappaB/Rel family and provides a link to the impaired B cell functions in mice deficient for these factors.
1	Thus	thus	ADP	IN	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	BLR1	BLR1	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	target	target	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Bob1	bob1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	link	link	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
39	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12625
# text = Document 0030013059 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013059	0030013059	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12626
# text = Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.
1	Defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	FosB	FosB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	anergic	anergic	PROPN	NNP	Number=Sing	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12627
# text = Anergic CD4+
1	Anergic	Anergic	PROPN	NNP	Number=Sing	_	_	_	_
2	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 12628
# text = Th cells do not produce IL-2 when challenged with Ag-pulsed accessory cells because of a transcriptional defect.
1	Th	th	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	challenged	challenge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	Ag-	Ag-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	pulsed	pulse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	because	because	ADP	IN	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	defect	defect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12629
# text = In this work, we report that these anergic T cells are defective in their ability to up-regulate protein binding and transactivation at two critical IL-2 DNA enhancer elements: NF-AT (nuclear factor of activated T cells; a sequence that binds a heterotrimeric NFATp, Fos, and Jun protein complex) and Activator Protein-1 (AP-1) (that binds Fos and Jun heterodimers).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	two	two	NUM	CD	NumType=Card	_	_	_	_
27	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	:	:	PUNCT	:	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	;	;	PUNCT	,	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
48	that	that	PRON	WDT	PronType=Rel	_	_	_	_
49	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	heterotrimeric	heterotrimeric	ADJ	JJ	Degree=Pos	_	_	_	_
52	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
58	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
59	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	Activator	Activator	PROPN	NNP	Number=Sing	_	_	_	_
63	Protein	protein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
65	1	1	NUM	CD	NumType=Card	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	_
71	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
72	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
73	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
74	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
77	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
78	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12630
# text = Western blot analysis of nuclear extracts showed that the impaired DNA-protein interactions in anergic T cells were associated with poor expression of the inducible AP-1 family members c-Fos, FosB, and JunB.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
7	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	poor	poor	ADJ	JJ	Degree=Pos	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	FosB	FosB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12631
# text = However, the reduced expression of these proteins was not the result of a global TCR/CD3-signaling defect because CD3 cross-linking induced an equivalent increase in intracellular-free calcium ions, as well as NFATp dephosphorylation, translocation to the nucleus, and DNA binding in both normal and anergic T cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	result	result	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	global	global	ADJ	JJ	Degree=Pos	_	_	_	_
16	TCR/CD3	TCR/CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-signaling	-signal	NOUN	NN	Number=Sing	_	_	_	_
18	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
21	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-linking	-link	NOUN	NN	Number=Sing	_	_	_	_
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
26	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
31	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
32	ions	ion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	as	as	ADV	RB	_	_	_	_	_
35	well	well	ADV	RB	Degree=Pos	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
38	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
47	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	both	both	CCONJ	CC	_	_	_	_	_
50	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
53	T	t	PROPN	NNP	Number=Sing	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12632
# text = Thus, defective IL-2 gene transcription appears to be due, at least in part, to a selective block in the expression of the AP-1 Fos and Jun family members in anergic T cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	due	due	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	at	at	ADV	RB	_	_	_	_	_
15	least	least	ADV	RBS	Degree=Sup	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
22	block	block	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
34	family	family	NOUN	NN	Number=Sing	_	_	_	_
35	members	member	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12633
# text = Document 0030013060 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013060	0030013060	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12634
# text = Structure and expression of the human GATA3 gene.
1	Structure	structure	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12635
# text = GATA3, a member of the GATA family that is abundantly expressed in the T-lymphocyte lineage, is thought to participate in T-cell receptor gene activation through binding to enhancers.
1	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	member	member	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	abundantly	abundantly	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	through	through	SCONJ	IN	_	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12636
# text = To understand GATA3 gene regulation, we cloned the human gene and the 5' end of the mouse GATA3 gene.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	GATA3	GATA3	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	cloned	clon	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	_
16	end	end	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
20	GATA3	GATA3	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12637
# text = We show that the human GATA3 gene contains six exons distributed over 17 kb of DNA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	six	six	NUM	CD	NumType=Card	_	_	_	_
10	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
11	distributed	distribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	over	over	ADP	IN	_	_	_	_	_
13	17	17	NUM	CD	NumType=Card	_	_	_	_
14	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12638
# text = The two human GATA3 zinc fingers are encoded by two separate exons highly conserved with those of GATA1, but no other structural homologies between these two genes can be found.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	_
5	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
6	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
12	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
13	highly	highly	ADV	RB	_	_	_	_	_
14	conserved	conserved	ADJ	JJ	Degree=Pos	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GATA1	GATA1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
24	homologies	homology	NOUN	NNS	Number=Plur	_	_	_	_
25	between	between	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	two	two	NUM	CD	NumType=Card	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12639
# text = The human and mouse GATA3 transcription units start at a major initiation site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
5	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	units	unit	NOUN	NNS	Number=Plur	_	_	_	_
8	start	start	VERB	VB	VerbForm=Inf	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12640
# text = The promoter sequence analysis of these two genes revealed that they are embedded within a CpG island and share structural features often found in the promoters of housekeeping genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	embedded	embedd	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	CpG	CpG	PROPN	NNP	Number=Sing	_	_	_	_
17	island	island	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
21	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
22	often	often	ADV	RB	_	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	housekeeping	housekeeping	NOUN	NN	Number=Sing	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12641
# text = Finally, we show that a DNA fragment containing the human GATA3 transcription unit, 3 kb upstream from the initiation site and 4 kb downstream from the polyadenylation site, displays T-cell specificity.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
9	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	GATA3	GATA3	NOUN	NN	Number=Sing	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
18	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
26	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	displays	display	NOUN	NNS	Number=Plur	_	_	_	_
33	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12642
# text = Document 0030013065 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013065	0030013065	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12643
# text = Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.
1	Agonistic	Agonistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
11	Fv	Fv	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
16	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
19	G28	G28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12644
# text = A single-chain Fv (sFv) was expressed from the variable regions of the CD40-specific mAb G28-5.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
5	Fv	Fv	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	sFv	sFv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
14	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
21	G28	G28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-5	-5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12645
# text = The molecule bound CD40 with a high affinity (2.2 nM) and was a monomer in solution.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
3	bound	bound	ADP	IN	_	_	_	_	_
4	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	2.2	2.2	NUM	CD	NumType=Card	_	_	_	_
11	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	monomer	monomer	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	solution	solution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12646
# text = Surprisingly, G28-5 sFv was a potent CD40 agonist that rapidly crosslinked CD40 on the cell surface but did not crosslink CD40-Ig in solution.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	G28	G28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	sFv	sFv	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
10	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
11	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	rapidly	rapidly	ADV	RB	_	_	_	_	_
14	crosslinked	crosslink	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	crosslink	crosslink	VERB	VB	VerbForm=Inf	_	_	_	_
24	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	solution	solution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12647
# text = G28-5 sFv was a more potent agonist than G28-5 IgG and was able to stimulate CD40 responses by B cells and monocytes.
1	G28	G28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-5	-5	NUM	CD	NumType=Card	_	_	_	_
3	sFv	sFv	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	more	more	ADV	RBR	_	_	_	_	_
7	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
8	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
9	than	than	ADP	IN	_	_	_	_	_
10	G28	G28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-5	-5	NUM	CD	NumType=Card	_	_	_	_
12	IgG	Igg	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
18	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
19	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	monocytes.	monocytes.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12648
# text = G28-5
1	G28	G28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-5	-5	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12649
# text = IgG partially blocked, whereas G28-5 sFv augmented CD40 responses during stimulation with natural ligand (gp39-CD8 fusion protein).
1	IgG	IgG	ADV	RB	_	_	_	_	_
2	partially	partially	ADV	RB	_	_	_	_	_
3	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	whereas	whereas	SCONJ	IN	_	_	_	_	_
6	G28	G28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	sFv	sFv	NOUN	NN	Number=Sing	_	_	_	_
10	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	gp39	gp39	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CD8	Cd8	NOUN	NN	Number=Sing	_	_	_	_
22	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12650
# text = These results indicate that the functional activity of ligands built from the binding site of G28-5 is highly dependent upon the size and physical properties of the molecule both in solution and on the cell surfaces.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
10	built	build	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	G28	G28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	highly	highly	ADV	RB	_	_	_	_	_
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	upon	upon	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	size	size	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
27	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
31	both	both	CCONJ	CC	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	solution	solution	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	surfaces	surfaces	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12651
# text = Document 0030013069 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013069	0030013069	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12652
# text = Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12653
# text = The expression of transiently transfected expression vectors under the control of the long terminal repeat (LTR) of the human immunodeficiency virus (HIV) or its enhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two human T-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transiently	transiently	ADV	RB	_	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
8	under	under	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
14	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
15	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
37	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	two	two	NUM	CD	NumType=Card	_	_	_	_
49	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
50	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
53	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	through	through	ADP	IN	_	_	_	_	_
55	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
56	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
58	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
59	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
60	or	or	CCONJ	CC	_	_	_	_	_
61	by	by	ADP	IN	_	_	_	_	_
62	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
63	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
64	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
65	or	or	CCONJ	CC	_	_	_	_	_
66	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
67	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
70	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
71	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
72	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12654
# text = We found a dissociation of NF-kappa B translocation from transactivation of either the HIV LTR or the HIV enhancer.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
17	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12655
# text = Interleukin 2 induced proliferation but not NF-kappa B translocation or LTR transactivation.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	not	not	ADV	RB	_	_	_	_	_
7	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12656
# text = Phorbol ester or specific antigen recognition induced HIV LTR transactivation, whereas stimulation with tumor necrosis factor or antibody to CD3 did not.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
3	or	or	CCONJ	CC	_	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
6	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
9	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
10	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
16	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
22	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12657
# text = The two latter signals were nevertheless able to induce NF-kappa B translocation with a pattern in the band-shift assay indistinguishable from that observed using phorbol ester.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	nevertheless	nevertheless	ADV	RB	_	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	band	band	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
23	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
24	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
29	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
30	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12658
# text = Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer-dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	finding	find	VERB	VBG	VerbForm=Ger	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
24	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	cloned	cloned	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	contrasts	contrast	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	_
35	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADV	RB	_	_	_	_	_
37	most	most	ADV	RBS	_	_	_	_	_
38	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
39	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
45	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
46	T	t	NOUN	NN	Number=Sing	_	_	_	_
47	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
48	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
49	from	from	ADP	IN	_	_	_	_	_
50	tumoral	tumoral	ADJ	JJ	Degree=Pos	_	_	_	_
51	T	t	PROPN	NNP	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
59	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
60	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12659
# text = Furthermore, our results suggest that events linked to T-cell activation, in addition to NF-kappa B translocation per se, induce functional interactions of the NF-kappa B complex with the HIV enhancer.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	events	event	NOUN	NNS	Number=Plur	_	_	_	_
8	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
22	per	per	ADP	IN	_	_	_	_	_
23	se	se	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	induce	induce	SCONJ	IN	_	_	_	_	_
26	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
27	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	_
38	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12660
# text = Document 0030013073 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013073	0030013073	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12661
# text = Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
10	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12662
# text = Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12663
# text = Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals.
1	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	since	since	SCONJ	IN	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	transforms	transform	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
29	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
32	animals	animal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12664
# text = We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	_
26	CTLL	Ctll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12665
# text = Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent.
1	Stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	SCONJ	IN	_	_	_	_	_
13	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12666
# text = Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	through	through	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
11	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12667
# text = The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	segregating	segregat	VERB	VBG	VerbForm=Ger	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	while	while	SCONJ	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	CRE	Cre	PROPN	NNP	Number=Sing	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	unnecessary	unnecessary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12668
# text = However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	another	another	DET	DT	_	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	soft	soft	ADJ	JJ	Degree=Pos	_	_	_	_
18	agar	agar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	CTLL	CTLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12669
# text = Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
20	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 12670
# text = T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12671
# text = Document 0030013074 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013074	0030013074	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12672
# text = Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein.
1	Lipopolysaccharide	Lipopolysaccharide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
9	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	bactericidal	bactericidal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	permeability	permeability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12673
# text = Endothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation.
1	Endothelial	Endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
7	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
17	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12674
# text = E-selectin is induced within 1-2 h, peaks at 4-6 h, and gradually returns to basal level by 24 h.
1	E-	E-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	within	within	ADP	IN	_	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	peaks	peak	NOUN	NNS	Number=Plur	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	gradually	gradually	ADV	RB	_	_	_	_	_
20	returns	return	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	24	24	NUM	CD	NumType=Card	_	_	_	_
26	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12675
# text = rBPI21, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), inhibited LPS-induced E-selectin expression when added at the same time as, and up to 6 h after, LPS.
1	rBPI21	rbpi21	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
5	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
7	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	bactericidal	bactericidal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	permeability	permeability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	increasing	increasing	NOUN	NN	Number=Sing	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	BPI	BPI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	when	when	ADV	WRB	PronType=Int	_	_	_	_
28	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
32	time	time	NOUN	NN	Number=Sing	_	_	_	_
33	as	as	ADV	RB	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	up	up	ADP	IN	_	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	6	6	NUM	CD	NumType=Card	_	_	_	_
39	h	h	NOUN	NN	Number=Sing	_	_	_	_
40	after	after	ADP	IN	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12676
# text = Delayed administration of rBPI21 also affected LPS-mediated activation of the nuclear factor, NF-kappa B.
1	Delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	_
2	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	rBPI21	rBPI21	PROPN	NNP	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12677
# text = Two to 4 h following LPS addition to endothelial cells, when NF-kappa B was already activated, addition of rBPI21 resulted in marked reduction of NF-kappa B detectable at 4 or 6 h.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	h	h	NOUN	NN	Number=Sing	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
6	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
7	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	already	already	ADV	RB	_	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	rBPI21	rbpi21	NUM	CD	NumType=Card	_	_	_	_
24	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	4	4	NUM	CD	NumType=Card	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	6	6	NUM	CD	NumType=Card	_	_	_	_
38	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12678
# text = These results indicate that endothelial activation requires continuous presence of LPS, and rBPI21 acts to reverse LPS-mediated endothelial activation by interrupting the on-going LPS signal.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
9	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	rBPI21	rBPI21	NUM	CD	NumType=Card	_	_	_	_
15	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	reverse	reverse	VERB	VB	VerbForm=Inf	_	_	_	_
18	LPS	Lps	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	interrupting	interrupt	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	on	on	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	going	go	VERB	VBG	VerbForm=Ger	_	_	_	_
29	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
30	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12679
# text = Document 0030013080 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013080	0030013080	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12680
# text = Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells.
1	Soluble	Soluble	ADJ	JJ	Degree=Pos	_	_	_	_
2	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
3	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	receptors	receptor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	inhibit	inhibit	ADJ	JJ	Degree=Pos	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	chronically	chronically	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	U1	U1	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12681
# text = Recombinant human tumor necrosis factor (TNF) binding protein-1 (r-h TBP-1) and recombinant human soluble dimeric TNF receptor (rhu TNFR:Fc) were used to determine the relative contributions of TNF to phorbol myristate acetate (PMA) and cytokine-induced human immunodeficiency virus type 1 (HIV-1) replication in chronically infected cell lines.
1	Recombinant	Recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	r	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	h	h	NOUN	NN	Number=Sing	_	_	_	_
17	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
25	dimeric	dimeric	ADJ	JJ	Degree=Pos	_	_	_	_
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	rhu	rhu	NOUN	NN	Number=Sing	_	_	_	_
30	TNFR:	TNFR:	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
39	contributions	contribution	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
44	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
45	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
54	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
55	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
56	type	type	NOUN	NN	Number=Sing	_	_	_	_
57	1	1	NUM	CD	NumType=Card	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
64	in	in	ADP	IN	_	_	_	_	_
65	chronically	chronically	ADV	RB	_	_	_	_	_
66	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
67	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
68	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12682
# text = Treatment of HIV-1-infected promonocytic U1 cells with r-h-TBP-1 or rhu TNFR:Fc reduced PMA-induced HIV-1 p24 antigen production in a concentration-dependent manner, with a maximal inhibition of approximately 90%.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	U1	u1	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	r-h	r-h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	rhu	rhu	PROPN	NNP	Number=Sing	_	_	_	_
19	TNFR:Fc	TNFR:Fc	PROPN	NNP	Number=Sing	_	_	_	_
20	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	p24	p24	NUM	CD	NumType=Card	_	_	_	_
28	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
29	production	production	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
40	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	approximately	approximately	ADV	RB	_	_	_	_	_
43	90%	90%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12683
# text = Maximal inhibition of p24 antigen production in T-lymphocytic ACH-2 cells was 47% with r-hTBP-1 and 42% with rhu TNFR:Fc.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p24	p24	NUM	CD	NumType=Card	_	_	_	_
5	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	ACH	ACh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	r-hTBP	r-hTBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	42	42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	%	%	SYM	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	rhu	rhu	NOUN	NN	Number=Sing	_	_	_	_
26	TNFR:	TNFR:	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	Fc.	Fc.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12684
# text = r-hTBP-1 and rhu TNFR:Fc also decreased p24 antigen synthesized by U1 cells in response to other stimuli, including phytohemagglutinin (PHA)-induced supernatant, granulocyte-macrophage colony-stimulating factor, interleukin-6, and TNF.
1	r-hTBP	r-hTBp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	rhu	rhu	NOUN	NN	Number=Sing	_	_	_	_
6	TNFR	Tnfr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
8	Fc	Fc	PROPN	NNP	Number=Sing	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	p24	p24	NUM	CD	NumType=Card	_	_	_	_
12	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
13	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	U1	U1	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
35	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12685
# text = Addition of r-hTBP-1 to U1 cells during the last 4 h of a 24 h incubation with PMA still inhibited p24 antigen production by 15%. U1 cells stimulated with 10(-7) M PMA released approximately 1 ng/ml endogenous TBP-1 with an initial peak observed at 1 h and a second peak at 24 h after PMA stimulation.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	r-hTBP	r-hTBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	U1	U1	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	last	last	ADJ	JJ	Degree=Pos	_	_	_	_
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	24	24	NUM	CD	NumType=Card	_	_	_	_
17	h	h	NOUN	NN	Number=Sing	_	_	_	_
18	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
21	still	still	ADV	RB	_	_	_	_	_
22	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	p24	p24	NUM	CD	NumType=Card	_	_	_	_
24	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	15%	15%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_
29	U1	U1	NUM	CD	NumType=Card	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
35	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	M	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
39	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	approximately	approximately	ADV	RB	_	_	_	_	_
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	ml	ml	ADJ	JJ	Degree=Pos	_	_	_	_
45	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
46	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
52	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
53	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	at	at	ADP	IN	_	_	_	_	_
55	1	1	NUM	CD	NumType=Card	_	_	_	_
56	h	h	NOUN	NN	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
59	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
60	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
61	at	at	ADP	IN	_	_	_	_	_
62	24	24	NUM	CD	NumType=Card	_	_	_	_
63	h	h	NOUN	NN	Number=Sing	_	_	_	_
64	after	after	ADP	IN	_	_	_	_	_
65	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
66	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12686
# text = r-hTBP-1 also partially reversed inhibition of U1 cellular proliferation caused by PMA.
1	r-hTBP	r-hTBp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	partially	partially	ADV	RB	_	_	_	_	_
6	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	U1	U1	NUM	CD	NumType=Card	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12687
# text = Both r-hTBP-1 and rhu TNFR:Fc blocked PMA induction of nuclear factor (NK)- kappa B DNA-binding activity in U1 cells in association with decreases in HIV-1 replication.
1	Both	both	DET	DT	_	_	_	_	_
2	r-hTBP	r-htbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	rhu	rhu	PROPN	NNP	Number=Sing	_	_	_	_
7	TNFR:Fc	TNFR:Fc	PROPN	NNP	Number=Sing	_	_	_	_
8	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	PMA	PMA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	U1	U1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	association	association	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12688
# text = We conclude that soluble TNF receptors can inhibit stimuli-induced HIV-1 expression and NK- kappa B DNA-binding activity in chronically infected U1 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
5	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
9	stimuli-induced	stimuli-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	chronically	chronically	ADV	RB	_	_	_	_	_
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	U1	U1	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12689
# text = Document 0030013083 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013083	0030013083	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12690
# text = Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	hyporesponsiveness	hyporesponsiveness	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
10	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
11	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	lipopolysaccharide/interferon-gamma	lipopolysaccharide/interferon-gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12691
# text = The work reported here resolves, at the level of gene regulation, the controversy as to whether or not human monocytes/macrophages can produce nitric oxide (NO) when stimulated with lipopolysaccharide (LPS), with or without co-stimulation by interferon-gamma (IFN-gamma).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	resolves	resolf	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	controversy	controversy	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	to	to	SCONJ	IN	_	_	_	_	_
18	whether	whether	SCONJ	IN	_	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
27	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
28	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	NO	no	INTJ	UH	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	when	when	ADV	WRB	PronType=Int	_	_	_	_
33	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	without	without	ADP	IN	_	_	_	_	_
43	co-stimulation	co-stimulation	NOUN	NN	Number=Sing	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12692
# text = Studies included structural comparison of the promoters for human and mouse inducible NO synthase (iNOS) genes, transfection and assay of human and mouse iNOS promoter regions in response to LPS +/- IFN-gamma, and electrophoretic mobility shift assays of kappa B response elements.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
4	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	human	human	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	NO	no	DET	DT	_	_	_	_	_
14	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	iNOS	inos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	human	human	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
27	iNOS	inos	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
34	+/-	+/-	PUNCT	:	_	_	_	_	_
35	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
41	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
42	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
43	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
46	B	b	NOUN	NN	Number=Sing	_	_	_	_
47	response	response	NOUN	NN	Number=Sing	_	_	_	_
48	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12693
# text = Two explanations for hyporesponsiveness of the human iNOS promoter to LPS +/- IFN-gamma were found: (1) multiple inactivating nucleotide substitutions in the human counterpart of the enhancer element that has been shown to regulate LPS/IFN-gamma induced expression of the mouse iNOS gene; and (2) and absence of one or more nuclear factors in human macrophages (e.g., an LPS-inducible nuclear factor-kappa
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	explanations	explanation	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	hyporesponsiveness	hyporesponsiveness	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	iNOS	inos	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
12	+/-	+/-	PUNCT	:	_	_	_	_	_
13	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	1	1	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
23	inactivating	inactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
25	substitutions	substitution	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	counterpart	counterpart	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
33	element	element	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
40	LPS/IFN	Lps/ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
48	iNOS	inos	NOUN	NN	Number=Sing	_	_	_	_
49	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	;	;	PUNCT	,	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	2	2	X	LS	_	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	_
55	and	and	CCONJ	CC	_	_	_	_	_
56	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	one	one	NUM	CD	NumType=Card	_	_	_	_
59	or	or	CCONJ	CC	_	_	_	_	_
60	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
61	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
62	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
65	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	e.g.	e.g.	X	FW	_	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
70	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
71	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
72	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
73	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
74	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12694
# text = B/Rel complex), that is (are) required for maximal expression of the gene.
1	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	ADJ	JJ	Degree=Pos	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12695
# text = The importance of resolution of this controversy is that future research in this area should be directed toward the understanding of alternative mechanisms that can result in the successful production of NO.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	controversy	controversy	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	future	future	ADJ	JJ	Degree=Pos	_	_	_	_
11	research	research	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	area	area	NOUN	NN	Number=Sing	_	_	_	_
15	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	toward	toward	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	successful	successful	ADJ	JJ	Degree=Pos	_	_	_	_
30	production	production	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	NO	no	DET	DT	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12696
# text = Document 0030013088 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013088	0030013088	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12697
# text = SRC-related proto-oncogenes and transcription factors in primary human T cells: modulation by cyclosporin A and FK506.
1	SRC	Src	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	:	:	PUNCT	:	_	_	_	_	_
15	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	cyclosporin	cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
18	A	a	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12698
# text = Activation of T lymphocytes induces transcription of genes encoding for lymphokines.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	lymphokines	lymphokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12699
# text = Interleukin-2 (IL-2) gene expression is controlled transcriptionally by the cooperative activity of specific trans-activating factors that bind to the IL-2 enhancer.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12700
# text = Cyclosporin A (CsA) and FK506 inhibit the production of IL-2 in T lymphocytes at the level of gene transcription.
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
2	A	A	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
8	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12701
# text = A member of the src gene family, the lymphocyte-specific protein tyrosine kinase, p56lck, has been implicated in IL-2 production.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	member	member	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	src	src	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12702
# text = CsA was found not to inhibit lck gene expression, nor the activity of the lck gene product.
1	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	not	not	ADV	RB	_	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	lck	lck	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	nor	nor	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	lck	lck	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12703
# text = However, CsA and FK506 inhibit the appearance of DNA binding activity of factors that bind to the NF-AT and AP-1 sites in the IL-2 enhancer.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
6	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12704
# text = Since the induction of NF-AT and AP-1 is induced by the same stimuli that stimulate IL-2 production, these results indicate that the immunosuppressant action of CsA and FK506 is exerted at the level of these trans-activating factors.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	results	result	NOUN	NNS	Number=Plur	_	_	_	_
27	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	_
31	action	action	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	at	at	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	level	level	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
46	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12705
# text = Document 0030013089 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013089	0030013089	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12706
# text = Transcriptional regulation during T-cell development: the alpha TCR gene as a molecular model.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	during	during	ADP	IN	_	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
15	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12707
# text = The regulation of gene expression during lymphocyte differentiation is a complex process involving interactions between multiple positive and negative transcriptional regulatory elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	process	process	NOUN	NN	Number=Sing	_	_	_	_
13	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
14	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
17	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12708
# text = In this article, transcriptional regulation of the archetypal T-cell-specific gene, alpha TCR, is discussed.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	article	article	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	archetypal	archetypal	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	alpha	alpha	ADP	IN	_	_	_	_	_
17	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12709
# text = Major recent developments, including the identification of novel families of transcription factors that regulate multiple T-cell genes during thymocyte ontogeny and T-cell activation, are described.
1	Major	major	ADJ	JJ	Degree=Pos	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	developments	development	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
10	families	family	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
22	ontogeny	ontogeny	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12710
# text = Document 0030013093 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013093	0030013093	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12711
# text = Regulation of GM-CSF gene transcription by core-binding factor.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	core	core	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12712
# text = GM-CSF gene activation in T cells is known to involve the transcription factors nuclear factor-kappa B, AP-1, NFAT, and Sp1.
1	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	NFAT	NFAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12713
# text = Here we demonstrate that the human GM-CSF promoter and enhancer also encompass binding sites for core-binding factor (CBF).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	encompass	encompass	SCONJ	IN	_	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	core	core	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12714
# text = Significantly, the CBF sites are in each case contained within the minimum essential core regions required for inducible activation of transcription.
1	Significantly	significantly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CBF	Cbf	NOUN	NN	Number=Sing	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	each	each	DET	DT	_	_	_	_	_
9	case	case	NOUN	NN	Number=Sing	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	minimum	minimum	ADJ	JJ	Degree=Pos	_	_	_	_
14	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
15	core	core	NOUN	NN	Number=Sing	_	_	_	_
16	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12715
# text = Furthermore, these core regions of the enhancer and promoter each encompass closely linked binding sites for CBF, AP-1, and NFATp.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	core	core	ADJ	JJ	Degree=Pos	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
11	each	each	DET	DT	_	_	_	_	_
12	encompass	encompass	NOUN	NN	Number=Sing	_	_	_	_
13	closely	closely	ADV	RB	_	_	_	_	_
14	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12716
# text = The GM-CSF promoter CBF site TGTGGTCA is located 51 bp upstream of the transcription start site and also overlaps a YY-1 binding site.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
5	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
6	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	TGTGGTCA	TGTGGTCA	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	51	51	NUM	CD	NumType=Card	_	_	_	_
12	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
13	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	start	start	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	overlaps	overlaps	ADV	RB	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	YY	Yy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12717
# text = A 2-bp mutation within the CBF site resulted in a 2-3-fold decrease in the activities of both a 69-bp proximal promoter fragment and a 627-bp full-length promoter fragment.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
18	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	69	69	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
28	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	627	627	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
36	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	length	length	NOUN	NN	Number=Sing	_	_	_	_
39	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
40	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12718
# text = Stepwise deletions into the proximal promoter also revealed that the CBF site, but not the YY-1 site, was required for efficient induction of transcriptional activation.
1	Stepwise	Stepwise	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
3	into	into	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	YY	Yy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12719
# text = The AML1 and CBF beta genes that encode CBF each have the ability to influence cell growth and differentiation and have been implicated as proto-oncogenes in acute myeloid leukemia.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AML1	Aml1	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	encode	encode	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	CBF	Cbf	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
10	each	each	DET	DT	_	_	_	_	_
11	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
30	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
31	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12720
# text = This study adds GM-CSF to a growing list of cytokines and receptors that are regulated by CBF and which control the growth, differentiation, and activation of hemopoietic cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	adds	add	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
10	list	list	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Int	_	_	_	_
22	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12721
# text = The GM-CSF locus may represent one of several target genes that are dysregulated in acute myeloid leukemia.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
5	locus	locus	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	target	target	NOUN	NN	Number=Sing	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	dysregulated	dysregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12722
# text = Document 0030013094 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013094	0030013094	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12723
# text = HIV-1
1	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12724
# text = Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
18	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12725
# text = This study demonstrates that human immunodeficiency virus type 1 (HIV-1)
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 12726
# text = Tat protein amplifies the activity of tumor necrosis factor (TNF), a cytokine that stimulates HIV-1 replication through activation of NF-kappa B. In HeLa cells stably transfected with the HIV-1 tat gene (HeLa-tat cells), expression of the Tat protein enhanced both TNF-induced activation of NF-kappa B and TNF-mediated cytotoxicity.
1	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	amplifies	amplify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_
30	In	in	ADP	IN	_	_	_	_	_
31	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	stably	stably	ADV	RB	_	_	_	_	_
34	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
41	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	HeLa	HeLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
53	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
54	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	both	both	CCONJ	CC	_	_	_	_	_
56	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
64	B	b	PROPN	NNP	Number=Sing	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
69	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12727
# text = A similar potentiation of TNF effects was observed in Jurkat T cells and HeLa cells treated with soluble Tat protein.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
19	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12728
# text = TNF-mediated activation of NF-kappa B and cytotoxicity involves the intracellular formation of reactive oxygen intermediates.
1	TNF	Tnf	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
12	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
19	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12729
# text = Therefore, Tat-mediated effects on the cellular redox state were analyzed.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
11	state	state	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12730
# text = In both T cells and HeLa cells HIV-1
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	HeLa	Hela	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	HIV	HIV	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
9	-1	-1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12731
# text = Tat suppressed the expression of Mn-dependent superoxide dismutase (Mn-SOD), a mitochondrial enzyme that is part of the cellular defense system against oxidative stress.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	superoxide	superoxide	NOUN	NN	Number=Sing	_	_	_	_
10	dismutase	dismutase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	mitochondrial	mitochondrial	ADJ	JJ	Degree=Pos	_	_	_	_
19	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	part	part	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	_
28	against	against	ADP	IN	_	_	_	_	_
29	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
30	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12732
# text = Thus, Mn-SOD RNA protein levels and activity were markedly reduced in the presence of Tat.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
6	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	markedly	markedly	ADV	RB	_	_	_	_	_
13	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12733
# text = Decreased Mn-SOD expression was associated with decreased levels of glutathione and a lower ratio of reduced:oxidized glutathione.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
16	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
20	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12734
# text = A truncated Tat protein (Tat1-72), known to transactivate the HIV-1 long terminal repeat (LTR), no longer affected Mn-SOD expression, the cellular redox state or TNF-mediated cytotoxicity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	truncated	truncated	ADJ	JJ	Degree=Pos	_	_	_	_
3	Tat	Tat	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	72	72	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
20	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
21	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	no	no	ADV	RB	_	_	_	_	_
27	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
28	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
37	state	state	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12735
# text = Thus, our experiments demonstrate that the C-terminal region of HIV-1
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12736
# text = Tat is required to suppress Mn-SOD expression and to induce pro-oxidative conditions reflected by a drop in reduced glutathione (GSH) and the GSH:oxidized GSH (GSSG) ratio.
1	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
6	Mn	Mn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	SOD	SOD	PROPN	NNP	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	pro-oxidative	pro-oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
14	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
15	reflected	reflect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	drop	drop	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	GSH	GSh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	:	:	PUNCT	:	_	_	_	_	SpaceAfter=No
29	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	GSH	GSH	PROPN	NNP	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	GSSG	GSSG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12737
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12738
# text = Document 0030013096 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013096	0030013096	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12739
# text = E2F-1 and a cyclin-like DNA repair enzyme, uracil-DNA glycosylase, provide evidence for an autoregulatory mechanism for transcription.
1	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	repair	repair	NOUN	NN	Number=Sing	_	_	_	_
11	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	uracil	uracil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	glycosylase	glycosylase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
19	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12740
# text = The cell cycle-dependent transcription factor, E2F-1, regulates the cyclin-like species of the DNA repair enzyme uracil-DNA glycosylase (UDG) gene in human osteosarcoma (Saos-2) cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	E2F	E2F	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
18	species	species	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	repair	repair	NOUN	NN	Number=Sing	_	_	_	_
23	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
24	uracil	uracil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	glycosylase	glycosylase	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	UDG	UDG	INTJ	UH	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	gene	gene	PRON	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	osteosarcoma	osteosarcoma	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	Saos	Saos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	X	LS	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12741
# text = We demonstrate, through the deletion of the human UDG promoter sequences, that expression of E2F-1 activates the UDG promoter through several E2F sites.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	through	through	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	UDG	Udg	NOUN	NN	Number=Sing	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	UDG	UDG	PROPN	NNP	Number=Sing	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	through	through	ADP	IN	_	_	_	_	_
25	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
26	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12742
# text = The major putative downstream site for E2F, located in the first exon, serves as a target for E2F-1/DP1 complex binding in vitro.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
4	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	exon	exon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	target	target	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-1/DP1	-1/DP1	PROPN	NNP	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12743
# text = We also provide evidence for the functional relationship between the cyclin-like UDG gene product and E2F.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
14	UDG	Udg	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	product	product	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12744
# text = High levels of UDG expression in a transient transfection assay result in the down-regulation of transcriptional activity through elements specific for E2F-mediated transcription.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	UDG	UDG	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
10	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
11	result	result	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12745
# text = Overexpression of UDG in Saos 2 cells was observed to delay growth late in G1 phase and transiently arrest these cells from progressing into the S phase.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	UDG	UDG	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	Saos	Saos	PROPN	NNP	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	delay	delay	VERB	VB	VerbForm=Inf	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	late	late	ADV	RB	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	G1	G1	PROPN	NNP	Number=Sing	_	_	_	_
16	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	transiently	transiently	ADV	RB	_	_	_	_	_
19	arrest	arrest	ADV	RBS	Degree=Sup	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	SCONJ	IN	_	_	_	_	_
23	progressing	progress	VERB	VBG	VerbForm=Ger	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	S	S	PROPN	NNP	Number=Sing	_	_	_	_
27	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12746
# text = This hypothetical model integrates one mechanism of DNA repair with the cell cycle control of gene transcription, likely through E2F.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	hypothetical	hypothetical	ADJ	JJ	Degree=Pos	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	_
4	integrates	integrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	repair	repair	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
14	control	control	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	likely	likely	ADV	RB	_	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12747
# text = This implicates E2F as a multifunctional target for proteins and enzymes, possibly, responsive to DNA damage through the negative effect of UDG on E2F-mediated transcriptional activity.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	implicates	implicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	F	F	PROPN	NNP	Number=Sing	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	multifunctional	multifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
8	target	target	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	possibly	possibly	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
19	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	UDG	UDG	PROPN	NNP	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12748
# text = Document 0030013098 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013098	0030013098	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12749
# text = A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
12	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12750
# text = The interleukin 2 (IL-2) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	type-specific	type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	integrate	integrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	information	information	NOUN	NN	Number=Sing	_	_	_	_
25	transmitted	transmit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
28	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
29	systems	system	NOUN	NNS	Number=Plur	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	production	production	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12751
# text = Using a combination of transfection, protein-DNA binding, and in vitro transcription methods, we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1), which recognizes a T-cell-specific response element (TCE) located within the IL-2 promoter.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	methods	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
23	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
29	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	for	for	ADP	IN	_	_	_	_	_
34	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	Factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	which	which	PRON	WDT	PronType=Rel	_	_	_	_
42	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
47	response	response	NOUN	NN	Number=Sing	_	_	_	_
48	element	element	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	TCE	TCE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	within	within	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	2	2	NUM	CD	NumType=Card	_	_	_	_
58	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12752
# text = Although the TCE is similar in sequence to a consensus NF kappa B site, several criteria indicate that TCF-1 is distinct from NF kappa B.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	TCE	Tce	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	B	PROPN	NNP	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
17	criteria	criterion	NOUN	NNS	Number=Plur	_	_	_	_
18	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12753
# text = However, like NF kappa B, TCF-1 activity is induced by phorbol esters and other T-cell activators.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	like	like	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activators	activator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12754
# text = Document 0030013109 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013109	0030013109	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12755
# text = Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937.
1	Isolation	Isolation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	42	42	NUM	CD	NumType=Card	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
11	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
12	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	monoblast	monoblast	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	U-	u-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12756
# text = To study the complexity and structural characteristics of zinc finger proteins expressed during human hematopoiesis and to isolate novel regulators of blood cell development, a degenerate oligonucleotide probe specific for a consensus zinc finger peptide domain was used to isolate 63 cDNA clones for Kruppel-related zinc finger genes from the human monoblast cell line U-937.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	complexity	complexity	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
7	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
10	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
19	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
20	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	degenerate	degenerate	NOUN	NN	Number=Sing	_	_	_	_
28	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
29	probe	probe	ADV	RB	_	_	_	_	_
30	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
34	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
35	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
36	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
37	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
42	63	63	NUM	CD	NumType=Card	_	_	_	_
43	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
44	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
45	for	for	ADP	IN	_	_	_	_	_
46	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
49	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
50	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
51	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
52	from	from	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
55	monoblast	monoblast	NOUN	NN	Number=Sing	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	line	line	NOUN	NN	Number=Sing	_	_	_	_
58	U-	u-	SYM	SYM	_	_	_	_	SpaceAfter=No
59	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12757
# text = By extensive nucleotide sequence and Northern blot analysis, these cDNA clones were found to originate from approximately 42 different genes (HZF 1-42) of which only 8 have previously been described.
1	By	by	ADP	IN	_	_	_	_	_
2	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
3	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cDNA	cDNa	ADJ	JJ	Degree=Pos	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	originate	originate	VERB	VB	VerbForm=Inf	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	approximately	approximately	ADV	RB	_	_	_	_	_
19	42	42	NUM	CD	NumType=Card	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HZF	Hzf	PROPN	NNP	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	42	42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	8	8	NUM	CD	NumType=Card	_	_	_	_
32	have	have	AUX	VB	VerbForm=Inf	_	_	_	_
33	previously	previously	ADV	RB	_	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12758
# text = Northern blot analysis showed that a majority of these genes were expressed at comparable levels in U-937 and HeLa cells.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	937	937	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12759
# text = The large number of individual genes represented among the 63 clones and their apparent non-cell-type-specific expression suggest that the majority of the Kruppel-related zinc finger genes are likely to be expressed in most human tissues.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
3	number	number	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	represented	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	among	among	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	63	63	NUM	CD	NumType=Card	_	_	_	_
11	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
15	non-cell	non-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	type-specific	type-specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
28	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
29	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12760
# text = In contrast, some of the genes displayed a restricted expression pattern, indicating that they represent potential regulators of monocyte differentiation or proliferation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	some	some	DET	DT	_	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
19	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12761
# text = Detailed structural analysis of the first 12 cDNAs (HZF 1-10) and a partial characterization of HZF 11-42 revealed that a common feature of human Kruppel-related zinc finger proteins is the presence of tandem arrays of zinc fingers ranging in number from 3 to over 20 that are preferentially located in the carboxy-terminal regions of the proteins.
1	Detailed	detailed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	12	12	NUM	CD	NumType=Card	_	_	_	_
8	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HZF	HZF	PROPN	NNP	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
18	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HZF	HZF	PROPN	NNP	Number=Sing	_	_	_	_
21	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	42	42	NUM	CD	NumType=Card	_	_	_	_
24	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
28	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
34	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
35	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
36	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
37	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
42	arrays	array	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
45	fingers	finger	NOUN	NNS	Number=Plur	_	_	_	_
46	ranging	rang	VERB	VBG	VerbForm=Ger	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	number	number	NOUN	NN	Number=Sing	_	_	_	_
49	from	from	ADP	IN	_	_	_	_	_
50	3	3	NUM	CD	NumType=Card	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	over	over	ADP	IN	_	_	_	_	_
53	20	20	NUM	CD	NumType=Card	_	_	_	_
54	that	that	PRON	WDT	PronType=Rel	_	_	_	_
55	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
56	preferentially	preferentially	ADV	RB	_	_	_	_	_
57	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
63	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12762
# text = In addition, several novel KRAB-containing zinc finger genes and a novel conserved sequence element were identified.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	KRAB	krab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
9	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
10	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
15	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12763
# text = Document 0030013110 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013110	0030013110	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12764
# text = Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types.
1	Contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
14	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12765
# text = Starting with a replication-incompetent molecular clone of human immunodeficiency virus type 1, lacking all the NF-kappa B and Sp1 binding sites present in the native long terminal repeat (LTR), proviruses containing reconstructed LTRs with individual or combinations of NF-kappa B and Sp1 elements were generated and evaluated for their capacity to produce virus progeny following transfection-cocultivation.
1	Starting	start	VERB	VBG	VerbForm=Ger	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	incompetent	incompetent	NOUN	NN	Number=Sing	_	_	_	_
7	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
17	all	all	DET	PDT	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Sp1	sp1	PROPN	NNP	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
31	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
32	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
33	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	proviruses	proviruse	NOUN	NNS	Number=Plur	_	_	_	_
39	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
40	reconstructed	reconstruct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	LTRs	LTR	NOUN	NNS	Number=Plur	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	individual	individual	NOUN	NN	Number=Sing	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
50	B	b	PROPN	NNP	Number=Sing	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
53	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
54	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	for	for	ADP	IN	_	_	_	_	_
59	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
60	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
61	to	to	PART	TO	_	_	_	_	_
62	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
63	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
64	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
65	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
66	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	cocultivation	cocultivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12766
# text = Virus stocks obtained from these experiments exhibited a continuum of replicative capacities in different human T-cell types depending on which element(s) was present in the LTR.
1	Virus	virus	ADJ	JJ	Degree=Pos	_	_	_	_
2	stocks	stock	NOUN	NNS	Number=Plur	_	_	_	_
3	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
7	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	continuum	continuum	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
12	capacities	capacitie	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	types	type	NOUN	NNS	Number=Plur	_	_	_	_
19	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	which	which	DET	WDT	PronType=Int	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	s	s	X	AFX	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12767
# text = For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites), a hierarchy of cellular permissivity to virus replication (peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat) was observed.
1	For	for	ADP	IN	_	_	_	_	_
2	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proviral	proviral	ADJ	JJ	Degree=Pos	_	_	_	_
8	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	LTRs	LTRs	PROPN	NNP	Number=Sing	_	_	_	_
11	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	and	and	CCONJ	CC	_	_	_	_	_
22	no	no	DET	DT	_	_	_	_	_
23	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	hierarchy	hierarchy	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
32	permissivity	permissivity	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
35	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
38	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
39	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
40	=	=	PUNCT	,	_	_	_	_	_
41	MT4	MT4	PROPN	NNP	Number=Sing	_	_	_	_
42	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
43	than	than	ADP	IN	_	_	_	_	_
44	H9	H9	NUM	CD	NumType=Card	_	_	_	_
45	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
46	than	than	ADP	IN	_	_	_	_	_
47	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
48	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
49	than	than	ADP	IN	_	_	_	_	_
50	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
53	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12768
# text = Of note was the associated emergence of second-site LTR revertants which involved an alteration of the TATA box.
1	Of	of	ADP	IN	_	_	_	_	_
2	note	note	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	associated	associated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
12	revertants	revertant	NOUN	NNS	Number=Plur	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	involved	involve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
20	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12769
# text = These results suggest that the human immunodeficiency virus type 1 LTR possesses functional redundancy which ensures virus replication in different T-cell types and is capable of changing depending on the particular combination of transcriptional factors present.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
12	possesses	possess	NOUN	NNS	Number=Plur	_	_	_	_
13	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
14	redundancy	redundancy	NOUN	NN	Number=Sing	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	ensures	ensure	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	types	type	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
27	of	of	SCONJ	IN	_	_	_	_	_
28	changing	change	VERB	VBG	VerbForm=Ger	_	_	_	_
29	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
33	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
36	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
37	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12770
# text = Document 0030013115 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013115	0030013115	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12771
# text = Oxidant-regulation of gene expression in the chronically inflamed intestine.
1	Oxidant	Oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	chronically	chronically	ADV	RB	_	_	_	_	_
10	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	intestine	intestine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12772
# text = It is becoming increasingly apparent that the chronic gut inflammation observed in the idiopathic inflammatory bowel diseases (e.g. ulcerative colitis, Crohn's disease) is associated with enhanced production of leukocyte-derived oxidants.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	becoming	become	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	increasingly	increasingly	ADV	RB	_	_	_	_	_
5	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
9	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
10	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
11	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	idiopathic	idiopathic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
17	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	e.g.	e.g.	X	FW	_	_	_	_	_
20	ulcerative	ulcerative	ADJ	JJ	Degree=Pos	_	_	_	_
21	colitis	colitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Crohn	Crohn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	's	's	PART	POS	_	_	_	_	_
25	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	production	production	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	oxidants	oxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12773
# text = Oxidants such as hydrogen peroxide are known to activate certain transcription factors such as nuclear transcription factor kappa beta.
1	Oxidants	Oxidant	NOUN	NNS	Number=Plur	_	_	_	_
2	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
3	as	as	ADP	IN	_	_	_	_	_
4	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
5	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12774
# text = Nuclear transcription factor kB (NF-kappa B) is a ubiquitous transcription factor and pleiotropic regulator of numerous genes involved in the immune and inflammatory responses.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12775
# text = This transcription factor is activated via the selective phosphorylation, ubiquination and degradation of its inhibitor protein I-kB thereby allowing translocation of NF-kappa B into the nucleus where it upregulates the transcription of a variety of adhesion molecules (e.g. ICAM-1, VCAM-1), cytokines (TNF, IL-1, IL-6) and enzymes (iNOS).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	via	via	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	ubiquination	ubiquination	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
21	thereby	thereby	ADV	RB	_	_	_	_	_
22	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
32	where	where	ADV	WRB	PronType=Rel	_	_	_	_
33	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
34	upregulates	upregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
42	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	e.g.	e.g.	X	FW	_	_	_	_	_
45	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	VCAM	VCAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
51	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	IL	IL	ADV	RB	_	_	_	_	SpaceAfter=No
63	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
64	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	enzymes	enzyme	NOUN	NNS	Number=Plur	_	_	_	_
68	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
69	iNOS	ino	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12776
# text = The proteolytic degradation of the post-translationally modified I-kappa B is known to be mediated by the 26S proteasome complex.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	post	post	X	AFX	_	_	_	_	SpaceAfter=No
7	-translationally	-translationally	ADV	RB	_	_	_	_	_
8	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	S	s	NOUN	NN	Number=Sing	_	_	_	_
22	proteasome	proteasome	DET	DT	_	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12777
# text = Based upon work from our laboratory, we propose that inhibition of NF-kappa B activation produces significant anti inflammatory activity which may be mediated by the inhibition of transcription of certain pro-inflammatory mediators and adhesion molecules.
1	Based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	upon	upon	ADP	IN	_	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	produces	produce	NOUN	NNS	Number=Plur	_	_	_	_
19	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
20	anti	anti	X	AFX	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
34	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
38	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12778
# text = Document 0030013119 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013119	0030013119	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12779
# text = Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13	13	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
16	linkage	linkage	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
25	5q23	5q23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	31	31	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12780
# text = Interleukin-13 (IL-13) and IL-4 are cytokines produced by T cells that are encoded by the q23-31 region of human chromosome 5.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-13	-13	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
14	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	q23	q23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-31	-31	NUM	CD	NumType=Card	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12781
# text = To investigate the regulation of IL-13 gene expression by T cells, we isolated and sequenced the human IL-13 gene, analyzed its 5'-flanking region for potential transcriptional activation elements, and examined its expression in nontransformed T-lineage cell populations.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	13	13	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	sequenced	sequence	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	13	13	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
28	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	nontransformed	nontransform	ADJ	JJ	Degree=Pos	_	_	_	_
46	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12782
# text = The human IL-13 gene was located 12.5-kb upstream of the IL-4 gene and 2-kb downstream of a CpG island.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	13	13	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	12.5	12.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
12	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
23	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	CpG	CpG	PROPN	NNP	Number=Sing	_	_	_	_
27	island	island	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12783
# text = The IL-13 gene 5' flank region included a segment with sequence homology to P elements of the IL-4 promoter involved in transcriptional activation in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	13	13	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	``	_	_	_	_	_
8	flank	flank	NOUN	NN	Number=Sing	_	_	_	_
9	region	region	NOUN	NN	Number=Sing	_	_	_	_
10	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12784
# text = Mutation of the IL-13
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-13	-13	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12785
# text = P element site significantly reduced IL-13 promoter activity in response to T-cell activation.
1	P	p	SYM	NFP	_	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	site	site	NOUN	NN	Number=Sing	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	13	13	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12786
# text = Oligonucleotides containing the IL-13 or IL-4 P element sites specifically bound the transcriptional activator protein, nuclear factor-activated T cells, preformed (NF-ATp), when incubated with nuclear protein extracts from activated T cells.
1	Oligonucleotides	Oligonucleotides	SCONJ	IN	_	_	_	_	_
2	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13	13	NUM	CD	NumType=Card	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	P	p	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	specifically	specifically	ADV	RB	_	_	_	_	_
15	bound	bound	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-activated	-activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	preformed	preform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	when	when	ADV	WRB	PronType=Int	_	_	_	_
35	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
39	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12787
# text = Similar to IL-4, IL-13 mRNA expression was highest in T-cell populations enriched for cells that had previously been primed in vivo or in vitro, indicating that priming increases the expression of the IL-13 and IL-4 genes in a coordinate manner.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
18	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	previously	previously	ADV	RB	_	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	primed	prim	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	priming	prim	VERB	VBG	VerbForm=Ger	_	_	_	_
35	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	13	13	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	4	4	NUM	CD	NumType=Card	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
51	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12788
# text = Because the primed T cells contain higher levels of nuclear NF-ATp, capable of binding to P elements of the IL-4 and IL-13 promoters, than do freshly-isolated T cells, the NF-AT-binding P elements are attractive candidates to mediate the coordinate expression of these two cytokine genes.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	primed	prim	ADJ	JJ	Degree=Pos	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	P	p	PROPN	NNP	Number=Sing	_	_	_	_
20	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	13	13	NUM	CD	NumType=Card	_	_	_	_
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	than	than	SCONJ	IN	_	_	_	_	_
33	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	freshly	freshly	ADV	RB	_	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
46	P	p	NOUN	NN	Number=Sing	_	_	_	_
47	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
48	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
49	attractive	attractive	ADJ	JJ	Degree=Pos	_	_	_	_
50	candidates	candidate	NOUN	NNS	Number=Plur	_	_	_	_
51	to	to	PART	TO	_	_	_	_	_
52	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
55	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
58	two	two	NUM	CD	NumType=Card	_	_	_	_
59	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
60	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12789
# text = Document 0030013122 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013122	0030013122	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12790
# text = Gene transcription through activation of G-protein-coupled chemoattractant receptors.
1	Gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	protein-	protein-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	chemoattractant	chemoattractant	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12791
# text = Receptors for leukocyte chemoattractants, including chemokines, are traditionally considered to be responsible for the activation of special leukocyte functions such as chemotaxis, degranulation, and the release of superoxide anions.
1	Receptors	Receptor	NOUN	NNS	Number=Plur	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
4	chemoattractants	chemoattractant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
7	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	traditionally	traditionally	ADV	RB	_	_	_	_	_
11	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	special	special	ADJ	JJ	Degree=Pos	_	_	_	_
20	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
21	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
22	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	chemotaxis	chemotaxis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	degranulation	degranulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	release	release	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	superoxide	superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
33	anions	anion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12792
# text = Recently, these G-protein-coupled serpentine receptors have been found to transduce signals leading to gene transcription and translation in leukocytes.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	G-protein-coupled	G-protein-coupled	ADJ	JJ	Degree=Pos	_	_	_	_
5	serpentine	serpentine	NOUN	NN	Number=Sing	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12793
# text = Transcription factors, such as NF kappa B and AP-1, are activated upon stimulation of the cells with several chemoattractants at physiologically relevant concentrations.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	upon	upon	ADP	IN	_	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
23	chemoattractants	chemoattractant	NOUN	NNS	Number=Plur	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	physiologically	physiologically	ADV	RB	_	_	_	_	_
26	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
27	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12794
# text = Activation of transcription factors through these receptors involves G-protein coupling and the activation of protein kinases.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
8	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
9	G-	G-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	coupling	coupling	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12795
# text = The underlying signaling pathways appear to be different from those utilized by TNF-alpha, a better characterized cytokine that induces the transcription of immediate-early genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
3	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
4	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
5	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
11	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
19	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12796
# text = Chemoattractants stimulate the expression of several inflammatory cytokines and chemokines, which in turn may activate their respective receptors and initiate an autocrine regulatory mechanism for persistent cytokine and chemokine gene expression.
1	Chemoattractants	Chemoattractant	NOUN	NNS	Number=Plur	_	_	_	_
2	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
7	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	autocrine	autocrine	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
28	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12797
# text = Document 0030013123 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013123	0030013123	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12798
# text = AML and Ets proteins regulate the I alpha1 germ-line promoter.
1	AML	AML	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	alpha1	alpha1	NUM	CD	NumType=Card	_	_	_	_
9	germ	germ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12799
# text = The immunoglobulin heavy chain (IgH) class switch recombination of B lymphocytes preferentially targets unrearranged IgH genes that have already been rendered transcriptionally active.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
3	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
4	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	class	class	NOUN	NN	Number=Sing	_	_	_	_
9	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
10	recombination	recombination	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	preferentially	preferentially	ADV	RB	_	_	_	_	_
15	targets	target	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	unrearranged	unrearrang	ADJ	JJ	Degree=Pos	_	_	_	_
17	IgH	Igh	ADJ	JJ	Degree=Pos	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	already	already	ADV	RB	_	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	rendered	render	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
25	active	active	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12800
# text = Transcription of the germ-line IgH genes is controlled by intervening (I) regions upstream of their switch regions.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	germ	germ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	IgH	Igh	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	intervening	intervene	VERB	VBG	VerbForm=Ger	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
17	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
21	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12801
# text = The I alpha1 promoter activates transcription of the human germ-line C alpha1 gene for IgA1 and mediates the transforming growth factor (TGF)-beta1 responsiveness of this locus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	alpha1	alpha1	X	GW	_	_	_	_	_
4	promoter	promoter	X	GW	_	_	_	_	_
5	activates	activate	X	GW	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	germ	germ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	C	c	NOUN	NN	Number=Sing	_	_	_	_
14	alpha1	alpha1	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	IgA1	IgA1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
29	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12802
# text = Here we show that the I alpha1 promoter contains several binding sites for the AML/PEBP2/CBF family of transcription factors and that AML and Ets proteins are major regulators of the basal and TGF-beta-inducible promoter activity.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	alpha1	alpha1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	AML/PEBP2/	Aml/pebp2/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	AML	aml	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Ets	et	PROPN	NNP	Number=Sing	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
29	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	TGF-beta	TGF-beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12803
# text = Our data constitute a starting point for studies to elucidate the molecular mechanism by which TGF-beta regulates IgA production.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	constitute	constitute	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	starting	starting	VERB	VBG	VerbForm=Ger	_	_	_	_
6	point	point	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	_
20	IgA	Iga	ADP	IN	_	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12804
# text = Document 0030013130 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013130	0030013130	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12805
# text = CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	negatively	negatively	ADV	RB	_	_	_	_	_
10	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-mediated	-mediated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	non-antigen	non-antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-selected	-select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12806
# text = We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
8	center	center	NOUN	NN	Number=Sing	_	_	_	_
9	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CL	CL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	01	01	NUM	CD	NumType=Card	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12807
# text = CL-01 cells are IgM+ IgD+
1	CL	Cl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	01	01	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	IgM	IgM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	+	+	SYM	SYM	_	_	_	_	_
8	IgD	IgD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 12808
# text = CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4.
1	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	+	+	SYM	SYM	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IgA	IgA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IgE	IgE	PROPN	NNP	Number=Sing	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	CD40L	CD40L	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12809
# text = Switching is hampered by CD30 coengagement, possibly through interference with the CD40-mediated NF-kappaB-dependent transcriptional activation of downstream C(H) genes.
1	Switching	switching	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	hampered	hamper	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
6	coengagement	coengagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	possibly	possibly	ADV	RB	_	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
25	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	H	H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12810
# text = The physiological relevance of this phenomenon is emphasized by similar CD30-mediated effects in naive B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
3	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	emphasized	emphasize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12811
# text = Expression of CD30 by these cells is induced by CD40L but is inhibited by B cell receptor coengagement and/or exposure to IL-6 and IL-12.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	CD40L	CD40L	NOUN	NN	Number=Sing	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	coengagement	coengagement	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	or	or	CCONJ	CC	_	_	_	_	_
22	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12812
# text = Our data suggest that CD30 critically regulates the CD40-mediated differentiation of non-antigen-selected human B cells.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
6	critically	critically	ADV	RB	_	_	_	_	_
7	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	non-antigen	non-antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-selected	-select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12813
# text = Document 0030013134 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013134	0030013134	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12814
# text = Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	B	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12815
# text = Transcription factor NF-kappa B must be released from cytoplasmic inhibitory molecules (I kappa
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	released	release	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
13	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12816
# text = Bs) in order to move to the nucleus and to activate its target genes.
1	Bs	bs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	order	order	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	move	move	VERB	VB	VerbForm=Inf	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	target	target	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12817
# text = Little is known about the mechanisms regulating the maintenance of constitutive nuclear NF-kappa B in some cell-types and of sustained nuclear NF-kappa B activity after stimulation.
1	Little	little	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	about	about	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	some	some	DET	DT	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	types	type	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12818
# text = Increased turnover has been implicated in the regulation of constitutive NF-kappa B activity in mature B cells.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12819
# text = We therefore compared the turnover of I kappa B alpha and I kappa B beta in mature B cells and HeLa cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	HeLa	Hela	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12820
# text = Both proteins display a high turnover in B cells although I kappa B beta is considerably more stable than I kappa B alpha.
1	Both	both	DET	DT	_	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	display	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	although	although	SCONJ	IN	_	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	considerably	considerably	ADV	RB	_	_	_	_	_
17	more	more	ADV	RBR	_	_	_	_	_
18	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
19	than	than	SCONJ	IN	_	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12821
# text = The half-life of both inhibitors is increased in HeLa cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	life	life	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12822
# text = In contrast, all other NF-kappa B/I kappa
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	all	all	DET	DT	_	_	_	_	_
5	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B/	B/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12823
# text = B molecules tested are relatively stable in both cell-types.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	relatively	relatively	ADV	RB	_	_	_	_	_
6	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12824
# text = The elevated turnover of endogenous I kappa B alpha in Namalwa cells is inhibited by a proteasome inhibitor and thus seems to be driven by the same degradation machinery as the slower turnover in non-B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Namalwa	Namalwa	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
18	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	thus	thus	ADV	RB	_	_	_	_	_
21	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
28	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
29	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	slower	slower	NOUN	NN	Number=Sing	_	_	_	_
33	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	non	non	X	AFX	_	_	_	_	SpaceAfter=No
36	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12825
# text = Furthermore, we investigated the processes involved in persistent activation of NF-kappa B. TNF-alpha signaling leads to a rapid depletion of cellular
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	processes	processe	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_
17	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
21	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
25	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12826
# text = I kappa B beta pools.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	pools	pool	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12827
# text = I kappa B alpha is efficiently resynthesized whereas I kappa B beta levels stay low for a prolonged time.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	efficiently	efficiently	ADV	RB	_	_	_	_	_
7	resynthesized	resynthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	whereas	whereas	SCONJ	IN	_	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	stay	stay	VERB	VB	VerbForm=Inf	_	_	_	_
15	low	low	ADV	RB	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12828
# text = NF-kappa B binding activity can be detected for several hours after stimulation.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12829
# text = We found that removal of the TNF-alpha containing medium causes a rapid decrease in nuclear NF-kappa B.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	medium	medium	ADJ	JJ	Degree=Pos	_	_	_	_
12	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
15	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12830
# text = A phosphoform of newly synthesized I kappa B alpha is visible when degradation by the proteasome is inhibited and new I kappa B alpha displays the same properties regarding phosphorylation and degradation in response to a second inducer.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	phosphoform	phosphoform	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	newly	newly	ADV	RB	_	_	_	_	_
5	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	visible	visible	ADJ	JJ	Degree=Pos	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	inhibited	inhibit	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	_
24	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
25	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
28	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
29	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
38	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12831
# text = There is no significant difference in the turnover of pre- and post-inductive I kappa B alpha.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	post	post	X	AFX	_	_	_	_	SpaceAfter=No
14	-inductive	-inductive	ADJ	JJ	Degree=Pos	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12832
# text = These observations suggest that resynthesis of I kappa B alpha and removal of the stimulus are obligatory steps for the inactivation of nuclear NF kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	resynthesis	resynthesis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	obligatory	obligatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12833
# text = Document 0030013136 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013136	0030013136	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12834
# text = HIV-1
1	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 12835
# text = Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B [see comments]
1	Vpr	Vpr	PROPN	NNP	Number=Sing	_	_	_	_
2	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
16	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12836
# text = The HIV-1 accessory gene product
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	accessory	accessory	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	product	product	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12837
# text = Vpr can influence viral pathogenesis by affecting viral replication as well as host cell transcription and proliferation.
1	Vpr	Vpr	NOUN	NN	Number=Sing	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	SCONJ	IN	_	_	_	_	_
7	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
8	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
9	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	host	host	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12838
# text = We have investigated the effects of Vpr on host cell activation and confirm that it influences cellular proliferation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Vpr	Vpr	PROPN	NNP	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	host	host	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	confirm	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12839
# text = However, we have also found that Vpr modulates T-cell receptor (TCR)-triggered apoptosis in a manner similar to that of glucocorticoids.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Vpr	Vpr	ADJ	JJ	Degree=Pos	_	_	_	_
9	modulates	modulate	NOUN	NNS	Number=Plur	_	_	_	_
10	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
22	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12840
# text = In the absence of TCR-mediated activation, Vpr induces apoptosis whereas in its presence, Vpr interrupts the expected induction of apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Vpr	Vpr	PROPN	NNP	Number=Sing	_	_	_	_
11	induces	induces	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	Vpr	Vpr	PROPN	NNP	Number=Sing	_	_	_	_
19	interrupts	interrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12841
# text = This regulation of apoptosis is linked to Vpr suppression of NF-kappa B activity via the induction of I kappa B, an inhibitor of NF-kappa B. Further, Vpr suppresses expression of IL-2, IL-10, IL-12, TNF alpha and IL-4, all of which are NF-kappa B-dependent.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	Vpr	Vpr	VERB	VB	VerbForm=Inf	_	_	_	_
9	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_
32	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	Vpr	Vpr	PROPN	NNP	Number=Sing	_	_	_	_
35	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	_
51	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	all	all	DET	DT	_	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	which	which	PRON	WDT	PronType=Rel	_	_	_	_
60	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
61	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
64	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12842
# text = The effects of Vpr could be reversed by RU486.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Vpr	Vpr	PROPN	NNP	Number=Sing	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	RU486	RU486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12843
# text = Our finding that Vpr can regulate NF-kappa B supports the hypothesis that some aspects of viral pathogenesis are the consequence of cell dysregulation by Vpr.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	finding	find	VERB	VBG	VerbForm=Ger	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Vpr	Vpr	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	some	some	DET	DT	_	_	_	_	_
16	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	Vpr.	Vpr.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12844
# text = Document 0030013138 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013138	0030013138	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12845
# text = Differential interaction of nuclear factors with the leukocyte-specific pp52 promoter in B and T cells.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	pp52	pp52	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	B	B	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12846
# text = The leukocyte-specific, cytoskeleton-binding pp52 (LSP-1, WP-34) protein is widely expressed in multiple leukocyte lineages, including B and T lymphocytes, granulocytes, and macrophages.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	cytoskeleton	cytoskeleton	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pp52	pp52	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LSP	Lsp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	WP	WP	SYM	NFP	_	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	34	34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	widely	widely	ADV	RB	_	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
25	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
26	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12847
# text = We previously detected a tissue-specific promoter preceding the exon encoding the N terminus of the pp52 leukocyte protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	preceding	precede	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
12	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	N	N	PROPN	NNP	Number=Sing	_	_	_	_
15	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pp52	pp52	NOUN	NN	Number=Sing	_	_	_	_
19	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12848
# text = Here we describe the functional characterization of this promoter and identification of the factors in B and T cells that regulate its activity.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12849
# text = The pp52 promoter contains an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a lone C/EBP motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pp52	pp52	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	initiator	initiator	NOUN	NN	Number=Sing	_	_	_	_
7	specifying	specify	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	''	_	_	_	_	_
12	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	pp52	pp52	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
18	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	SP1	Sp1	NOUN	NN	Number=Sing	_	_	_	_
23	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	lone	lone	ADJ	JJ	Degree=Pos	_	_	_	_
28	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
30	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12850
# text = All these motifs are essential and collectively control transcriptional activity.
1	All	all	DET	PDT	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	collectively	collectively	ADV	RB	_	_	_	_	_
8	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12851
# text = DNA binding studies and Ab supershift assays revealed that different combinations of factors interact with these motifs in B cells vs T cells.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Ab	Ab	X	GW	_	_	_	_	_
6	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
7	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	vs	versus	ADP	IN	Abbr=Yes	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12852
# text = The Ets motifs are preferentially bound by PU-1 in B cell extracts from all stages of development, whereas a different Ets family member reacts with these motifs in T cell extracts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
3	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	preferentially	preferentially	ADV	RB	_	_	_	_	_
6	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	Ets	Ets	PROPN	NNP	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	member	member	NOUN	NN	Number=Sing	_	_	_	_
27	reacts	react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12853
# text = The C/EBP motif is bound by Ig/EBP-1 in pre-B cell and T cell extracts, but is replaced by nuclear factor-IL-6beta or a nuclear factor-IL-6beta-Ig/EBP-1 heterodimer in plasmacytoma cell extracts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	EBP	Ebp	NOUN	NN	Number=Sing	_	_	_	_
4	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Ig/EBP	Ig/EBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
13	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	replaced	replace	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-IL	-il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	factor-IL-6beta-Ig/EBP	factor-il-6beta-ig/ebp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12854
# text = Despite its reported role as a negative regulator of transcription, Ig/EBP-1 appears to exert a stimulatory effect on this promoter.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
3	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Ig/EBP	Ig/EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12855
# text = These findings reveal the features controlling the pp52 promoter in B and T cells and provide the foundation for determining the regulation of this promoter in other leukocyte lineages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
6	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	pp52	pp52	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	foundation	foundation	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
29	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12856
# text = Document 0030013140 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013140	0030013140	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12857
# text = Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B [published erratum appears in Science 1991 Oct 4;254(5028):11]
1	Isolation	Isolation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rel-	rel-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	potentially	potentially	ADV	RB	_	_	_	_	_
10	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kD	k	NOUN	NN	Number=Sing	_	_	_	_
15	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	B	PROPN	NNP	Number=Sing	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
24	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	Science	Science	PROPN	NNP	Number=Sing	_	_	_	_
27	1991	1991	NUM	CD	NumType=Card	_	_	_	_
28	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
29	4;254	4;254	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	5028	5028	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	:11	:11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12858
# text = A DNA probe that spanned a domain conserved among the proto-oncogene c-rel, the Drosophila morphogen dorsal, and the p50 DNA binding subunit of NF-kappa B was generated from Jurkat T cell complementary DNA with the polymerase chain reaction (PCR) and degenerate oligonucleotides.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	spanned	span	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	among	among	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
13	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
18	morphogen	morphogen	NOUN	NN	Number=Sing	_	_	_	_
19	dorsal	dorsal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
26	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	from	from	ADP	IN	_	_	_	_	_
35	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
36	T	T	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
38	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
39	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
43	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
44	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	degenerate	degenerate	ADJ	JJ	Degree=Pos	_	_	_	_
50	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12859
# text = This probe was used to identify a rel-related complementary DNA that hybridized to a 2.6-kilobase messenger RNA present in human T and B lymphocytes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rel-related	rel-relate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	hybridized	hybridize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	2.6	2.6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kilobase	kilobase	NOUN	NN	Number=Sing	_	_	_	_
18	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
19	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
20	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12860
# text = In vitro transcription and translation of the complementary DNA resulted in the synthesis of a protein with an apparent molecular size of 65 kilodaltons (kD).
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
20	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
21	size	size	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	65	65	NUM	CD	NumType=Card	_	_	_	_
24	kilodaltons	kilodalton	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12861
# text = The translated protein showed weak DNA binding with a specificity for the kappa B binding motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
16	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12862
# text = This protein-DNA complex comigrated with the complex obtained with the purified human p65 NF-kappa
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	comigrated	comigrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12863
# text = B subunit and binding was inhibited by I kappa B-alpha and -beta proteins.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12864
# text = In addition, the 65-kD protein associated with the p50 subunit of NF-kappa B and the kappa B probe to form a complex with the same electrophoretic mobility as the NF-kappa B-DNA complex.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kD	k	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
41	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12865
# text = Therefore the rel-related 65-kD protein may represent the p65 subunit of the active NF-kappa B transcription factor complex.
1	Therefore	therefore	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	rel-related	rel-related	ADJ	JJ	Degree=Pos	_	_	_	_
4	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kD	kd	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12866
# text = Document 0030013143 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013143	0030013143	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12867
# text = Inhibition of phorbol ester-induced monocytic differentiation by dexamethasone is associated with down-regulation of c-fos and c-jun (AP-1).
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
4	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12868
# text = Previous studies have shown that treatment of human myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of monocytic differentiation and expression of the c-jun and c-fos early response genes.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	12-	12-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
15	-tetradecanoylphorbol	-tetradecanoylphorbol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
38	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12869
# text = The present work demonstrates that the glucocorticoid dexamethasone inhibits TPA-induced increases in c-jun and c-fos mRNA levels in U-937 leukemia cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
9	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
10	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	937	937	NUM	CD	NumType=Card	_	_	_	_
27	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12870
# text = These findings were associated with a block in appearance of the monocytic phenotype, including inhibition of TPA-induced increases in lamin A, lamin C, and vimentin transcripts.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	block	block	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	lamin	lamin	NOUN	NN	Number=Sing	_	_	_	_
24	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	lamin	lamin	PROPN	NNP	Number=Sing	_	_	_	_
27	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	vimentin	vimentin	ADJ	JJ	Degree=Pos	_	_	_	_
31	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12871
# text = Other studies have demonstrated that TPA-induced monocytic differentiation and expression of the c-jun and c-fos genes in myeloid leukemia cells are regulated by protein kinase C (PKC).
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	C	C	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12872
# text = The finding that dexamethasone has no effect on TPA-induced activation of PKC suggests that this glucocorticoid inhibits signals downstream or parallel to this enzyme.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	dexamethasone	dexamethasone	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
15	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
19	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
21	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12873
# text = Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	1	1	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
27	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	2	2	X	LS	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
43	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	not	not	PART	RB	_	_	_	_	_
45	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
46	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
47	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	3	3	X	LS	_	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	_
53	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
57	of	of	ADP	IN	_	_	_	_	_
58	both	both	DET	DT	_	_	_	_	_
59	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
60	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
61	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
62	at	at	ADP	IN	_	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
65	level	level	NOUN	NN	Number=Sing	_	_	_	_
66	by	by	ADP	IN	_	_	_	_	_
67	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12874
# text = To further define the effects of dexamethasone at the molecular level, we prepared a series of deleted c-jun promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	prepared	prepare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	series	series	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
23	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
27	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12875
# text = Increases in CAT activity during transient expression of these constructs in TPA-treated U-937 cells could be assigned to the region (-97 to -20) of the promoter that contains the AP-1 binding site.
1	Increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	937	937	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	assigned	assign	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
26	97	97	NUM	CD	NumType=Card	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
41	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12876
# text = This induction of CAT activity was sensitive to dexamethasone.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	dexamethasone	dexamethasone	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12877
# text = These findings suggest that dexamethasone down-regulates TPA-induced transcription of the c-jun gene during monocytic differentiation by inhibiting activation of the AP-1 site.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	dexamethasone	dexamethasone	PRON	NN	Number=Sing	_	_	_	_
6	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12878
# text = Document 0030013146 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013146	0030013146	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12879
# text = Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-12	-12	NUM	CD	NumType=Card	_	_	_	_
5	p40	p40	NUM	CD	NumType=Card	_	_	_	_
6	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
9	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
10	via	via	ADP	IN	_	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12880
# text = Interleukin-12 is produced in response to infection with bacteria or parasites or to bacterial constituents such as LPS in monocytes/macrophages and dendritic cells, and also generated by the interaction between activated T cells and antigen-presenting cells via CD40-CD40 ligand (CD40L).
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	parasites	parasite	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
17	constituents	constituent	NOUN	NNS	Number=Plur	_	_	_	_
18	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	also	also	ADV	RB	_	_	_	_	_
31	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
35	between	between	ADP	IN	_	_	_	_	_
36	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	T	T	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	presenting	present	VERB	VBG	VerbForm=Ger	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	via	via	ADP	IN	_	_	_	_	_
45	CD40-CD40	CD40-CD40	NUM	CD	NumType=Card	_	_	_	_
46	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	CD40L	CD40L	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12881
# text = So far, transcriptional analyses of p40 have been carried out only using bacterial constituents such as LPS as stimuli.
1	So	so	ADV	RB	_	_	_	_	_
2	far	far	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
8	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	out	out	ADP	RP	_	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
15	constituents	constituent	NOUN	NNS	Number=Plur	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12882
# text = In the present study, we have characterized the transcriptional induction of p40 by CD40 ligation in a human B lymphoblastoid cell line, Daudi, and a human acute monocytic leukemia cell line, THP-1.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p40	p40	NUM	CD	NumType=Card	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
16	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
31	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12883
# text = These cells, stimulated by an agonistic monoclonal antibody against CD40 or by transfection with a CD40L expression vector, secreted p40 and showed enhanced p40 mRNA expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	agonistic	agonistic	ADJ	JJ	Degree=Pos	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
10	against	against	ADP	IN	_	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	p40	p40	NUM	CD	NumType=Card	_	_	_	_
27	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12884
# text = Sequence analysis of the p40 promoter region identified two potential nuclear factor (NF)-kappaB binding sites conserved between mouse and human.
1	Sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	p40	p40	NUM	CD	NumType=Card	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12885
# text = Electrophoretic mobility shift assay revealed that the potential NF-kappaB binding sequence which is located around 120 bp upstream of the transcription initiation site in murine and human p40 genes formed an NF-kappaB complex with nuclear extract from Daudi cells stimulated by CD40 ligation.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	around	around	ADP	IN	_	_	_	_	_
18	120	120	NUM	CD	NumType=Card	_	_	_	_
19	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
20	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	p40	p40	NUM	CD	NumType=Card	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
40	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
47	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12886
# text = Moreover, transfection of Daudi cells with the polymerized NF-kappaB binding sequence ligated to a thymidine kinase/chloramphenicol acetyltransferase (CAT) reporter plasmid greatly induced CAT activity, but transfection with the polymerized mutated NF-kappaB binding sequence did not.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Daudi	Daudi	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	polymerized	polymerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	ligated	ligate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
22	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
27	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
28	greatly	greatly	ADV	RB	_	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	polymerized	polymerize	NOUN	NN	Number=Sing	_	_	_	_
38	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
42	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
43	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
44	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12887
# text = These results suggest that the NF-kappaB binding site located around 120 bp upstream of the transcription initiation site in murine and human p40 promoter regions could be important for the p40 induction by CD40 ligation via activation of NF-kappaB.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	around	around	ADV	RB	_	_	_	_	_
13	120	120	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
37	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
38	via	via	ADP	IN	_	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12888
# text = Document 0030013151 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013151	0030013151	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12889
# text = Surfactant protein
1	Surfactant	Surfactant	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 12890
# text = A activates NF-kappa B in the THP-1 monocytic cell line.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12891
# text = The expression of many genes for which products are involved in inflammation is controlled by the transcriptional regulator nuclear factor (NF)-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Int	_	_	_	_
8	products	product	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12892
# text = Because surfactant protein (SP) A is involved in local host defense in the lung and alters immune cell function by modulating the expression of proinflammatory cytokines as well as surface proteins involved in inflammation, we hypothesized that SP-A exerts its action, at least in part, via activation of NF-kappa B.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	surfactant	surfactant	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	A	a	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	local	local	ADJ	JJ	Degree=Pos	_	_	_	_
12	host	host	NOUN	NN	Number=Sing	_	_	_	_
13	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	alters	alter	X	GW	_	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
29	as	as	ADV	RB	_	_	_	_	_
30	well	well	ADV	RB	Degree=Pos	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
34	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
39	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
45	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
46	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	at	at	ADV	RB	_	_	_	_	_
49	least	least	ADV	RBS	Degree=Sup	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	via	via	ADP	IN	_	_	_	_	_
54	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
59	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12893
# text = We used gel shift assays to determine whether SP-A activated NF-kappa B in the THP-1 cell line, a human monocytic cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	whether	whether	SCONJ	IN	_	_	_	_	_
9	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12894
# text = Activation of NF-kappa B in THP-1 cells by SP-A doses as low as 1 microgram/ml occurred within 30 min of SP-A treatment, peaked at 60 min, and then declined.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	THP	THP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
17	as	as	ADV	RB	_	_	_	_	_
18	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	microgram	microgram	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
24	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	30	30	NUM	CD	NumType=Card	_	_	_	_
27	min	min	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	peaked	peake	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	60	60	NUM	CD	NumType=Card	_	_	_	_
37	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	then	then	ADV	RB	PronType=Dem	_	_	_	_
41	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12895
# text = This activation is inhibited by known inhibitors of NF-kappa B or by simultaneous treatment of the cells with surfactant lipids.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	surfactant	surfactant	ADJ	JJ	Degree=Pos	_	_	_	_
22	lipids	lipid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12896
# text = Moreover, the NF-kappa B inhibitors blocked SP-A-dependent increases in tumor necrosis factor-alpha mRNA levels.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12897
# text = These observations suggest a mechanism by which SP-A plays a role in the pathogenesis of some lung conditions and point to potential therapeutic measures that could be used to prevent SP-A induced inflammation in the lung.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	A	a	NOUN	NN	Number=Sing	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	some	some	DET	DT	_	_	_	_	_
19	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
20	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	point	point	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	potential	potential	VERB	VB	VerbForm=Inf	_	_	_	_
25	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
26	measures	measure	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
33	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12898
# text = Document 0030013152 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013152	0030013152	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12899
# text = Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB.
1	Inactivation	Inactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12900
# text = In resting T lymphocytes, the transcription factor NF-kappaB is sequestered in the cytoplasm via interactions with members of the I kappa B family of inhibitors, including IkappaBalpha and IkappaBbeta.
1	In	in	SCONJ	IN	_	_	_	_	_
2	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	I	I	PROPN	NNP	Number=Sing	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12901
# text = During normal T-cell activation, IkappaBalpha is rapidly phosphorylated, ubiquitinated, and degraded by the 26S proteasome, thus permitting the release of functional NF-kappaB.
1	During	during	ADP	IN	_	_	_	_	_
2	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
3	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	rapidly	rapidly	ADV	RB	_	_	_	_	_
10	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	ubiquitinated	ubiquitinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	S	be	NOUN	NN	Number=Sing	_	_	_	_
20	proteasome	proteasome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	thus	thus	ADV	RB	_	_	_	_	_
23	permitting	permitt	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	release	release	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12902
# text = In contrast to its transient pattern of nuclear induction during an immune response, NF-kappaB is constitutively activated in cells expressing the Tax transforming protein of human T-cell leukemia virus type I (HTLV-1).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
6	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	constitutively	constitutively	ADV	RB	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
26	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
33	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
34	type	type	NOUN	NN	Number=Sing	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12903
# text = Recent studies indicate that HTLV-1 Tax targets IkappaBalpha to the ubiquitin-proteasome pathway.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
10	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ubiquitin-	ubiquitin-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12904
# text = However, it remains unclear how this viral protein induces a persistent rather than transient NF-kappaB response.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	how	how	ADV	WRB	PronType=Int	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	persistent	persistent	NOUN	NN	Number=Sing	_	_	_	_
13	rather	rather	ADV	RB	_	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12905
# text = In this report, we provide evidence that in addition to acting on IkappaBalpha, Tax stimulates the turnover Of IkappaBbeta via a related targeting mechanism.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	SCONJ	IN	_	_	_	_	_
12	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
17	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
20	Of	of	ADP	IN	_	_	_	_	_
21	IkappaBbet	IkappaBbet	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	via	via	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12906
# text = Like IkappaBalpha, Tax-mediated breakdown of IkappaBbeta in transfected T lymphocytes is blocked either by cell-permeable proteasome inhibitors or by mutation Of IkappaBbeta at two serine residues present within its N-terminal region.
1	Like	like	ADP	IN	_	_	_	_	_
2	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	breakdown	breakdown	ADP	IN	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	permeable	permeable	ADJ	JJ	Degree=Pos	_	_	_	_
21	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
22	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
26	Of	of	ADP	IN	_	_	_	_	_
27	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
31	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
32	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
33	within	within	ADP	IN	_	_	_	_	_
34	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
35	N-	n-	PUNCT	:	_	_	_	_	SpaceAfter=No
36	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12907
# text = Despite the dual specificity of HTLV-1 Tax for IkappaBalpha and IkappaBbeta at the protein level, Tax selectively stimulates NF-kappaB-directed transcription of the IkappaBalpha gene.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
4	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
20	selectively	selectively	ADV	RB	_	_	_	_	_
21	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12908
# text = Consequently, IkappaBbeta protein expression is chronically downregulated in HTLV-1-infected T lymphocytes.
1	Consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	chronically	chronically	ADV	RB	_	_	_	_	_
8	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12909
# text = These findings with IkappaBbeta provide a potential mechanism for the constitutive activation of NF-kappaB in Tax-expressing cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	_
5	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12910
# text = Document 0030013156 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013156	0030013156	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12911
# text = The role of nuclear factor-kappa B in cytokine gene regulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-kappa	-kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12912
# text = Transcription factors are DNA-binding proteins that regulate gene expression.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12913
# text = Nuclear factor-kappa B (NF-kappa B) is a critical transcription factor for maximal expression of many cytokines that are involved in the pathogenesis of inflammatory diseases, such as adult respiratory distress syndrome (ARDS) and sepsis syndrome.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
22	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
36	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
37	distress	distress	NOUN	NN	Number=Sing	_	_	_	_
38	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	ARDS	ARDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	sepsis	sepsis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12914
# text = Activation and regulation of NF-kappa B are tightly controlled by a group of inhibitory proteins (I kappa B) that sequester NF-kappa B in the cytoplasm of immune/inflammatory effector cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	tightly	tightly	ADV	RB	_	_	_	_	_
11	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	group	group	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	sequester	sequester	NOUN	NN	Number=Sing	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
35	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12915
# text = NF-kappa B activation involves signaled phosphorylation, ubiquitination, and proteolysis of I kappa B.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	signaled	signale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	ubiquitination	ubiquitination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12916
# text = Liberated NF-kappa B migrates to the nucleus, where it binds to specific promoter sites and activates gene transcription.
1	Liberated	Liberate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	migrates	migrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	where	where	ADV	WRB	PronType=Rel	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12917
# text = The activation of NF-kappa B initiates both extracellular and intracellular regulatory events that result in autoregulation of the inflammatory cascade through modulation of NF-kappa B activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12918
# text = Recently, activation of NF-kappa B has been linked to ARDS and has been shown to be a critical proximal step in the initiation of neutrophilic inflammation in animal models.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	ARDS	ARDS	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
22	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
23	step	step	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	neutrophilic	neutrophilic	ADJ	JJ	Degree=Pos	_	_	_	_
29	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
32	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12919
# text = Activation of NF-kappa B can be inhibited in vivo by treatment with antioxidants, corticosteroids, and the induction of endotoxin tolerance.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	corticosteroids	corticosteroid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	endotoxin	endotoxin	NOUN	NN	Number=Sing	_	_	_	_
24	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12920
# text = Identification of more specific and efficacious inhibitors of NF-kappa B activation might prove beneficial for the treatment of cytokine-mediated inflammatory diseases.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	efficacious	efficacious	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
15	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
16	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12921
# text = Document 0030013159 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013159	0030013159	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12922
# text = Superantigens activate HIV-1 gene expression in monocytic cells.
1	Superantigens	Superantigens	NOUN	NNS	Number=Plur	_	_	_	_
2	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12923
# text = Binding of superantigens to MHC class II molecules results in transduction of biochemical signals leading to cellular activation and gene expression.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	superantigens	superantigen	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
9	results	result	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12924
# text = We demonstrate that the staphylococcal superantigens toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxin A (SEA) activate HIV-1-LTR-driven transcription of chloramphenicol acetyl transferase in the human monocytic cell line THP-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	staphylococcal	staphylococcal	NOUN	NN	Number=Sing	_	_	_	_
6	superantigens	superantigen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	toxic	toxic	ADJ	JJ	Degree=Pos	_	_	_	_
8	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
9	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
10	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TSST	Tsst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	X	LS	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	staphylococcal	staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
20	enterotoxin	enterotoxin	NOUN	NN	Number=Sing	_	_	_	_
21	A	a	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	SEA	Sea	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
26	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-LTR-	-LTR-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
34	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
35	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	line	line	NOUN	NN	Number=Sing	_	_	_	_
42	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12925
# text = Induction of HIV-1-LTR-driven transcription in THP-1 cells by superantigens was associated with the induction of nuclear factor-kappa B DNA-binding activity.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	superantigens	superantigen	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12926
# text = Superantigens also increased viral protein secretion from the granulocyte-macrophage colony-stimulating factor-pretreated chronically infected human monocytic cell line U1. Induction of HIV-1 gene expression in monocytic cells by superantigens occurred via tumor necrosis factor-alpha-dependent and -independent mechanisms.
1	Superantigens	Superantigens	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
12	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	chronically	chronically	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	U1	u1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_
26	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	superantigens	superantigen	NOUN	NNS	Number=Plur	_	_	_	_
38	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	via	via	ADP	IN	_	_	_	_	_
40	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
41	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
42	factor-alpha	factor-alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
48	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12927
# text = Our results suggest that superantigens and other MHC class II ligands may activate HIV-1 gene expression in monocytes/macrophages.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	superantigens	superantigen	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12928
# text = Document 0030013160 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013160	0030013160	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12929
# text = Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
14	function	function	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12930
# text = Induction of apoptosis in lymphocytes, which may account for the therapeutic effects of glucocorticoids in various diseases including leukemia, depends on the glucocorticoid receptor.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
13	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
18	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
19	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
20	leukemia	leukemion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12931
# text = However, the events leading from the activated receptor to cell lysis are not understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
12	lysis	lysis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12932
# text = A prevailing hypothesis postulates induction of so-called 'lysis genes' by the activated receptor.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	prevailing	prevailing	NOUN	NN	Number=Sing	_	_	_	_
3	hypothesis	hypothesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	postulates	postulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
11	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	'	'	PUNCT	''	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12933
# text = In this study, we show that an activation-deficient glucocorticoid receptor mutant is as effective as the wild-type receptor in repression of AP-1 activity, inhibition of interleukin-2 production, inhibition of c-myc expression and induction of apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
12	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
42	myc	myc	NOUN	NN	Number=Sing	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12934
# text = Furthermore, we show that retinoic acid can also induce apoptosis in these cells through the retinoic acid receptor, whose repressive functions but not target site specificity, are similar to those of the glucocorticoid receptor.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
11	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
18	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
22	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
23	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12935
# text = Therefore, the primary effect of the receptor in glucocorticoid-mediated apoptosis correlates with transcriptional repression rather than activation and could be mediated by interference with other transcription factors required for cell survival.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
14	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
18	rather	rather	ADV	RB	_	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12936
# text = Document 0030013172 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013172	0030013172	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12937
# text = OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins.
1	OBF	Obf	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	association	association	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12938
# text = Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
5	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	components	component	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	lymphoid	lymphoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12939
# text = Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oct-binding factor 1 (OBF-1), a novel protein that specifically associates with Oct-1 and Oct-2.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
4	screen	screen	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	yeast	yeast	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	_
16	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
17	Oct-	Oct-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	OBF	Obf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	specifically	specifically	ADV	RB	_	_	_	_	_
32	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-1	-1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12940
# text = Biochemical studies demonstrate that OBF-1 has no intrinsic DNA-binding activity and recognizes the POU domains of Oct-1 and Oct-2, but not those of Oct-4 and Oct-6.
1	Biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	OBF	OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	POU	pou	NOUN	NN	Number=Sing	_	_	_	_
19	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12941
# text = The OBF-1 mRNA is expressed in a highly cell-specific manner, being most abundant in B cells and essentially absent in most of the other cells or tissues tested.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	OBF	Obf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	highly	highly	ADV	RB	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
17	most	most	ADV	RBS	_	_	_	_	_
18	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	essentially	essentially	ADV	RB	_	_	_	_	_
24	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
33	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12942
# text = Furthermore, expression of OBF-1 in HeLa cells selectively stimulates the activity of a natural immunoglobulin promoter in an octamer site-dependent manner.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	OBF	OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	selectively	selectively	ADV	RB	_	_	_	_	_
12	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
18	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12943
# text = Thus, OBF-1 has all the properties expected for a B cell-specific transcriptional coactivator protein.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	OBF	OBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	all	all	DET	PDT	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
10	expected	expect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12944
# text = Document 0030013173 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013173	0030013173	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12945
# text = T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity: a preliminary report.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
7	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
8	exhibit	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
11	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	preliminary	preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
24	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12946
# text = Recent data suggest that the poor induction of a T-cell response to human renal cell carcinoma (RCC) may be related to alterations in signal transduction pathways.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	poor	poor	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
28	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
29	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12947
# text = We report that T cells from RCC patients have two alterations in kappa B motif-specific DNA-binding activity.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12948
# text = The first alteration involves the constitutive expression of substantial kappa B-binding activity in nuclear extracts, which was observed in the electrophoretic mobility shift assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
4	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
24	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12949
# text = The magnitude of kappa B activity in unstimulated patient T cells was similar to that observed in T cells from normal individuals that had been activated in vitro.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
9	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12950
# text = On the basis of Western blotting experiments using antibodies to kappa
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
6	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
7	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 12951
# text = B/Rel family proteins, the kappa B-binding activity constitutively expressed in T cells from RCC patients is composed mostly of the NF-kappa B1 (p50) subunit.
1	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	Rel	Rel	ADJ	JJ	Degree=Pos	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	constitutively	constitutively	ADV	RB	_	_	_	_	_
14	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	mostly	mostly	ADV	RB	_	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12952
# text = The second abnormality in kappa B-binding activity in T cells from these patients is that RelA, a member of the Rel homology family which is part of the normal NF-kappa B complex, was not induced in the nucleus following activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	abnormality	abnormality	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	ADP	IN	Typo=Yes	_	_	_	_
17	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	member	member	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
24	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	part	part	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
39	not	not	PART	RB	_	_	_	_	_
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
44	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12953
# text = Western blotting analysis did not detect any RelA in nuclear extracts either before or after stimulation of T cells.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
7	any	any	DET	DT	_	_	_	_	_
8	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	before	before	ADV	RB	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12954
# text = The altered kappa B-binding activity in T cells from RCC patients may impair their capacity to respond normally to various stimuli.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	impair	impair	VERB	VB	VerbForm=Inf	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
19	normally	normally	ADV	RB	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
22	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12955
# text = Document 0030013180 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013180	0030013180	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12956
# text = Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo.
1	Resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
10	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
13	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
14	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12957
# text = TNF is one of the cytokines secreted by the cells of the immune system.
1	TNF	TNF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
7	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
14	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12958
# text = Our data demonstrate that those cell lines lacking capability to form metastatic tumors in vivo are susceptible to TNF induced apoptosis in vitro.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
9	capability	capability	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
12	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
13	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	TNF	TNF	AUX	VB	VerbForm=Inf	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12959
# text = However, cell lines with high metastatic potential are resistant to TNF in vitro.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
7	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
8	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	TNF	TNF	VERB	VB	VerbForm=Inf	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12960
# text = Furthermore, the same cell lines were resistant to cytolytic action of other cytotoxic proteins secreted by LAK cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	action	action	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	LAK	Lak	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12961
# text = Our data showed that TNF resistance in vitro correlates with the increased level of transcription factor NF-kappaB.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
9	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12962
# text = This finding may provide a tool to improve current protocols of immunotherapy and insights to how tumor cells are or are not killed by LAK cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	tool	tool	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	improve	improve	VERB	VB	VerbForm=Inf	_	_	_	_
9	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
10	protocols	protocol	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	immunotherapy	immunotherapy	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	how	how	ADV	WRB	PronType=Int	_	_	_	_
17	tumor	tumor	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	killed	kill	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	LAK	Lak	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12963
# text = Document 0030013182 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013182	0030013182	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12964
# text = Evidence for a trans-acting activator function regulating the expression of the human CD5 antigen.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	trans	trans	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
8	function	function	NOUN	NN	Number=Sing	_	_	_	_
9	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	CD5	Cd5	NOUN	NN	Number=Sing	_	_	_	_
16	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12965
# text = Interspecies somatic cell hybrids were generated by fusing the mouse T-lymphoma cell line, BW5147, with normal human T lymphocytes at different stages of differentiation.
1	Interspecies	Interspecy	NOUN	NNS	Number=Plur	_	_	_	_
2	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	fusing	fuse	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	BW	BW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	5147	5147	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	NOUN	NN	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12966
# text = Thymocytes, activated peripheral T lymphocytes, or an activated T-cell clone were used as human partners, respectively, in three independent fusions.
1	Thymocytes	Thymocytes	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	NOUN	NN	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	partners	partner	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	three	three	NUM	CD	NumType=Card	_	_	_	_
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12967
# text = Irrespective of the human cell partner used for fusion, a certain number of hybrids lost CD5 surface expression over a period of time in culture.
1	Irrespective	irrespective	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	partner	partner	NOUN	NN	Number=Sing	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
13	number	number	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
16	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	CD5	CD5	NUM	CD	NumType=Card	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	over	over	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	period	period	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12968
# text = Analysis at the phenotype and genetic level showed that lack of CD5 expression was due neither to segregation of human autosome 11, on which the CD5 gene has been mapped, nor to deletion of the CD5 structural gene.
1	Analysis	Analysis	NOUN	NN	Number=Sing	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD5	CD5	NUM	CD	NumType=Card	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	due	due	ADP	IN	_	_	_	_	_
16	neither	neither	CCONJ	CC	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	segregation	segregation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	autosome	autosome	NOUN	NN	Number=Sing	_	_	_	_
22	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CD5	Cd5	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	nor	nor	CCONJ	CC	_	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	CD5	CD5	PROPN	NNP	Number=Sing	_	_	_	_
39	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12969
# text = Furthermore, loss of CD5 surface expression correlated with the absence of specific mRNA.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	loss	loss	ADP	IN	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CD5	CD5	NUM	CD	NumType=Card	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12970
# text = Since these hybrids preferentially segregate human chromosomes, these results indicate the existence of a non-syntenic trans-active locus, or loci, positively controlling the expression of the human CD5 gene.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
4	preferentially	preferentially	ADV	RB	_	_	_	_	_
5	segregate	segregate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	non-syntenic	non-syntenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
20	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	loci	loci	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	positively	positively	ADV	RB	_	_	_	_	_
26	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	CD5	Cd5	NOUN	NN	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12971
# text = Document 0030013186 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013186	0030013186	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12972
# text = Suppression by azelastine hydrochloride of NF-kappa B activation involved in generation of cytokines and nitric oxide.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	azelastine	azelastine	ADJ	JJ	Degree=Pos	_	_	_	_
4	hydrochloride	hydrochloride	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
18	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12973
# text = The influence of the anti-allergy agent azelastine hydrochloride (Azeptin) on NF-kappa B activation associated with the generation of cytokines and nitric oxide (NO) was investigated in various kinds of human and mouse cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	anti-allergy	anti-allergy	ADJ	JJ	Degree=Pos	_	_	_	_
6	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
7	azelastine	azelastine	NOUN	NN	Number=Sing	_	_	_	_
8	hydrochloride	hydrochloride	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Azeptin	Azeptin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
26	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NO	no	INTJ	UH	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
34	kinds	kind	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	human	human	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12974
# text = Azeptin dose-dependently suppressed both DNA and protein synthesis in human gingival fibroblasts (HF) and also suppressed blastogenesis of human peripheral blood lymphocytes (PBL).
1	Azeptin	Azeptin	PROPN	NNP	Number=Sing	_	_	_	_
2	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	dependently	dependently	ADV	RB	_	_	_	_	_
5	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HF	HF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	blastogenesis	blastogenesis	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	PBL	PBL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12975
# text = Generation of tumor necrosis factor-alpha, interleukin 1-beta, granulocyte-macrophage colony-stimulating factor and interleukin-6 from 10(-5) M Azeptin-treated PBL and human monocytes (HM) was decreased to approximately 1/3 to 2/3 of the control levels.
1	Generation	generation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
17	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
28	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	M	m	NOUN	NN	Number=Sing	_	_	_	_
31	Azeptin-	Azeptin-	PUNCT	:	_	_	_	_	SpaceAfter=No
32	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	PBL	pBl	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	HM	HM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	approximately	approximately	ADV	RB	_	_	_	_	_
44	1/3	1/3	NUM	CD	NumType=Card	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	2/3	2/3	NUM	CD	NumType=Card	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	control	control	NOUN	NN	Number=Sing	_	_	_	_
50	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12976
# text = In parallel with the decreased cytokine generation, each cytokine mRNA was less expressed in the presence of 10(-5) M Azeptin.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	each	each	DET	DT	_	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
14	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	M	be	NOUN	NN	Number=Sing	_	_	_	_
24	Azeptin	Azeptin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12977
# text = In addition, both inducible nitric oxide synthase-mRNA level and NO generation in mouse peritoneal macrophages were suppressed by 10(-5) M Azeptin.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	nitric	nitric	ADJ	JJ	Degree=Pos	_	_	_	_
7	oxide	oxide	NOUN	NN	Number=Sing	_	_	_	_
8	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NO	no	DET	DT	_	_	_	_	_
14	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
17	peritoneal	peritoneal	ADJ	JJ	Degree=Pos	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	M	be	NOUN	NN	Number=Sing	_	_	_	_
27	Azeptin	Azeptin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12978
# text = Being compatible with those results, Azeptin (10(-5) M) suppressed activation of NF-kappa B in PBL, HM and HF.
1	Being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
2	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Azeptin	Azeptin	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	HM	HM	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	HF	HF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12979
# text = These results appear to indicate that suppression of cytokine and NO generation by Azeptin results at least partially from the inhibition of NF-kappa B activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	indicate	indicate	VERB	VB	VerbForm=Inf	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NO	no	DET	DT	_	_	_	_	_
12	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Azeptin	Azeptin	PROPN	NNP	Number=Sing	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	at	at	ADV	RB	_	_	_	_	_
17	least	least	ADV	RBS	Degree=Sup	_	_	_	_
18	partially	partially	ADV	RB	_	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12980
# text = Document 0030013190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013190	0030013190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12981
# text = Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A [see comments]
1	Affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
5	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
12	than	than	ADP	IN	_	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	PROPN	NNP	Number=Sing	_	_	_	_
15	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	see	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12982
# text = The flow of information from calcium-mobilizing receptors to nuclear factor of activated T cells (NFAT)-dependent genes is critically dependent on interaction between the phosphatase calcineurin and the transcription factor NFAT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	information	information	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	mobilizing	mobilize	VERB	VBG	VerbForm=Ger	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	critically	critically	ADV	RB	_	_	_	_	_
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
28	between	between	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
31	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12983
# text = A high-affinity calcineurin-binding peptide was selected from combinatorial peptide libraries based on the calcineurin docking motif of NFAT.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
5	calcineurin-	calcineurin-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	selected	select	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	combinatorial	combinatorial	ADJ	JJ	Degree=Pos	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	libraries	library	NOUN	NNS	Number=Plur	_	_	_	_
14	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
18	docking	docke	VERB	VBG	VerbForm=Ger	_	_	_	_
19	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12984
# text = This peptide potently inhibited NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
3	potently	potently	ADV	RB	_	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NFAT	NFAT	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NFAT	Nfat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	without	without	SCONJ	IN	_	_	_	_	_
21	affecting	affecte	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	NFAT	Nfat	ADV	RB	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12985
# text = Substitution of the optimized peptide sequence into the natural calcineurin docking site increased the calcineurin responsiveness of NFAT.
1	Substitution	Substitution	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	optimized	optimize	ADJ	JJ	Degree=Pos	_	_	_	_
5	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	into	into	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
10	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
11	docking	docke	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
16	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12986
# text = Compounds that interfere selectively with the calcineurin-NFAT interaction without affecting calcineurin phosphatase activity may be useful as therapeutic agents that are less toxic than current drugs.
1	Compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	interfere	interfere	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	selectively	selectively	ADV	RB	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	calcineurin-	calcineurin-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	without	without	SCONJ	IN	_	_	_	_	_
11	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
12	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
13	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
20	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
24	toxic	toxic	ADJ	JJ	Degree=Pos	_	_	_	_
25	than	than	ADP	IN	_	_	_	_	_
26	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
27	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12987
# text = Document 0030013195 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013195	0030013195	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 12988
# text = Effects of prostaglandin E2 on Th0-type human T cell clones: modulation of functions of nuclear proteins involved in cytokine production.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	prostaglandin	prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
4	E2	E2	NUM	CD	NumType=Card	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	Th0	Th0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 12989
# text = The effects of prostaglandin E2 (PGE2) on cytokine production and proliferation of the CD4+ human helper T cell clone SP-B21 were investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	prostaglandin	prostaglandin	NOUN	NN	Number=Sing	_	_	_	_
5	E2	E2	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
20	T	t	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
23	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	B21	b21	NOUN	NN	Number=Sing	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12990
# text = In cells stimulated with anti-CD3 mAb, PGE2 inhibited cell proliferation and the production of all the cytokines examined.
1	In	in	ADP	IN	_	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
6	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	PGE2	PGE2	PART	TO	Abbr=Yes	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	all	all	DET	PDT	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
19	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12991
# text = Addition of rIL-2 fully restored the proliferative response and partially restored the production of IL-4 and IL-5, but not that of other cytokines.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	rIL	rIL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	fully	fully	ADV	RB	_	_	_	_	_
7	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	partially	partially	ADV	RB	_	_	_	_	_
13	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12992
# text = In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
10	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	/A23187	/A23187	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	partially	partially	ADV	RB	_	_	_	_	_
32	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	production	production	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
37	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12993
# text = Therefore, the effects of PGE2 vary depending on the mode of T cell activation, and the IL-4 and IL-5 are regulated differently from other cytokines.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	PGE2	PGE2	NOUN	NN	Number=Sing	_	_	_	_
7	vary	vary	NOUN	NN	Number=Sing	_	_	_	_
8	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	differently	differently	ADV	RB	_	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12994
# text = In a mobility shift assay, only the NF-kappa B (p50/p50) homodimer was observed in a complex formed with the kappa B sequence in unstimulated SP-B21 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
32	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	21	21	NUM	CD	NumType=Card	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12995
# text = When cells were stimulated with anti-CD3 mAb or PMA/A23187, a complex formation of NF-kappa B (p50/p65) heterodimer with the kappa B sequence was induced.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
7	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	A23187	A23187	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
24	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12996
# text = Interestingly, PGE2 or di-butyryl (Bt2)cAMP abolished the binding of NF-kappa B (p50/p65) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA/A23187.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	di-butyryl	di-butyryl	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	Bt2	Bt2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
21	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
34	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	/A	/A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	23187	23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12997
# text = Our results suggest that the target of PGE2 action is a component in the signal transduction pathway leading to the activation of protein kinase C.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	target	target	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PGE2	PGE2	NUM	CD	NumType=Card	_	_	_	_
9	action	action	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	component	component	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
18	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12998
# text = However, the inhibition of the T cell activation signals by PGE2 is selective.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 12999
# text = PGE2 enhanced the complex formation with NF-AT, AP-1 and CLE0 sequences when the cells were activated by either anti-CD3 mAb or PMA/A23187 stimulation.
1	PGE2	PGE2	X	LS	_	_	_	_	_
2	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
5	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	_
16	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
17	when	when	ADV	WRB	PronType=Int	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	either	either	CCONJ	CC	_	_	_	_	_
24	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
25	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/A23187	/A23187	NUM	CD	NumType=Card	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 13000
# text = It seems therefore that PGE2, by elevating cAMP levels, interferes with the activation pathway for NF-kappa B but not for NF-AT, AP-1 or CLE0 binding protein.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	PGE2	Pge2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	elevating	elevat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	ADV	RB	_	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	AT	AT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 13001
# text = Document 0030013198 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013198	0030013198	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 13002
# text = Cell-to-cell contact activates the long terminal repeat of human immunodeficiency virus 1 through its kappaB motif.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
10	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
11	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
20	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 13003
# text = Cell-to-cell contact between peripheral blood lymphocytes and transfected human colonic carcinoma cell line HT29 activates transcription of the long terminal repeats (LTR) of human immunodeficiency virus.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	colonic	colonic	NOUN	NN	Number=Sing	_	_	_	_
15	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	HT29	HT29	NUM	CD	NumType=Card	_	_	_	_
19	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
24	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
25	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
32	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 13004
# text = HIV-1 LTR transcription is controlled by a complex array of virus-encoded and cellular proteins.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
11	array	array	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	encoded	encod	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 13005
# text = Using various constructs expressing a lacZ reporter gene under the control of the intact or three deleted forms of HIV-1 LTR, we obtained evidence that the kappaB regulatory elements located in the U3 region are involved in cell-to-cell activation of HIV-1 LTR.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
3	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
4	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	lacZ	lacZ	PROPN	NNP	Number=Sing	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	under	under	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	control	control	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	intact	intact	NOUN	NN	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	deleted	delet	ADJ	JJ	Degree=Pos	_	_	_	_
18	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
26	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
33	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	U3	U3	NOUN	NN	Number=Sing	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	1	1	NUM	CD	NumType=Card	_	_	_	_
51	LTR.	LTR.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 13006
# text = Cell-to-cell contact activates in vitro binding of the nuclear factor kappaB (NF-kappaB) p50/p65 heterodimer to an HIV-1 kappaB oligonucleotide.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
7	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
10	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
23	p65	p65	NUM	CD	NumType=Card	_	_	_	_
24	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	_
31	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 13007
# text = Cell-to-cell contact activation of NF-kappaB was only partially inhibited by 100 microM pyrrolidine dithiocarbamate and was not correlated with a significant decrease of cellular inhibitor kappaB alpha.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	partially	partially	ADV	RB	_	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	100	100	NUM	CD	NumType=Card	_	_	_	_
18	microM	microm	NUM	CD	NumType=Card	_	_	_	_
19	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
20	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
28	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
31	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
32	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 13008
# text = NF-kappaB nuclear activation was not detectable before 1 h after cell contact and was dependent on protein synthesis.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	before	before	ADP	IN	_	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	h	h	NOUN	NN	Number=Sing	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 13009
# text = Document 0030013199 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030013199	0030013199	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n